108 results on '"Mutlu, Levent Cem"'
Search Results
2. Predictive value of NLRC3 levels for pulmonary hypertension in patients with chronic obstructive pulmonary disease.
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Yılmaz, Meltem, Mutlu, Levent Cem, Alpsoy, Şeref, Akyüz, Aydın, Çelikkol, Aliye, and Kaymaz, Özlem
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CHRONIC obstructive pulmonary disease , *PULMONARY hypertension , *OBSTRUCTIVE lung diseases , *PULMONARY artery , *AIRWAY (Anatomy) - Abstract
Objectives: Chronic obstructive pulmonary disease (COPD) is a medical condition defined by persistent airflow limitation and respiratory symptoms caused by airway and/or alveolar abnormalities. Pulmonary hypertension (PH) is one of the cardiovascular comorbidities associated with COPD. We investigated the correlation of NLRC3 levels in patients with COPD with prognostic and surrogate parameters of PH on echocardiography and examined whether it could be used to predict PH in this patient population. Methods: A total of 80 patients diagnosed with COPD and 40 healthy volunteers as the control group were included in the study. The COPD group was further divided into two subgroups according to the systolic pulmonary artery pressure (sPAP) as follows: sPAP<35 mmHg and sPAP≥35 mmHg. The enzyme-linked immunosorbent assay (ELISA) method was used to determine the levels of NLRC3 in peripheral blood. Results: Patients with sPAP≥35 mmHg had a lower mean NLRC3 level than those with sPAP<35 mmHg (P=0.006). The NLRC3 levels showed a significant negative correlation with sPAP, tricuspid regurgitation velocity, right atrium, and pulmonary artery diameter. For NLRC3, the cut-off value was found to be 271,486 ng/L, with a sensitivity of 74%, and specificity of 63% in distinguishing patients with sPAP≥35 mmHg from all patients with sPAP<35 mmHg. Conclusion: Our study results suggest that NLRC3 levels measured from peripheral blood are predictive of PH in patients with COPD. Although the exact function of NLRC3 in the lungs, COPD, and PH have not been completely understood, we believe these findings will serve as a model for future studies. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Methemoglobinemia after local anesthesia with prilocaine in adults: four case reports.
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Yılmaz, Meltem, İşcan, Arif, and Mutlu, Levent Cem
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METHEMOGLOBINEMIA ,LOCAL anesthesia ,PRILOCAINE ,PHYSIOLOGICAL transport of oxygen ,CYANOSIS - Abstract
Methemoglobinemia is a serious hematological disease characterized by the incapability of sufficient oxygen delivery to tissues and cyanosis when iron within hemoglobin in ferrous form (Fe+2) is oxidized to ferric form (Fe+3). Methemoglobinemia may be congenital or acquired. While prilocaine-induced methemoglobinemia can be seen in newborns and early pediatric ages, it is a rare condition in adults. We aimed to investigate prilocaine-induced adult methemoglobinemia with four cases. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Effect of CPAP on New Endothelial Dysfunction Marker, Endocan, in People With Obstructive Sleep Apnea.
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Altintas, Nejat, Mutlu, Levent Cem, Akkoyun, Dursun Cayan, Aydin, Murat, Bilir, Bulent, Yilmaz, Ahsen, and Malhotra, Atul
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Humans ,Sleep Apnea ,Obstructive ,Vascular Diseases ,Proteoglycans ,Neoplasm Proteins ,Polysomnography ,Continuous Positive Airway Pressure ,Risk Factors ,Adult ,Aged ,Middle Aged ,Female ,Male ,Carotid Intima-Media Thickness ,Biomarkers ,biomarkers ,carotid intima media thickness ,endocan ,flow-mediated dilatation ,obstructive sleep apnea ,Cardiovascular System & Hematology ,Clinical Sciences - Abstract
Obstructive sleep apnea (OSA) is associated with increased cardiovascular (CV) morbidity and mortality. Endocan is a surrogate endothelial dysfunction marker that may be associated with CV risk factors. In this study, we tested whether serum endocan is a biomarker for OSA. Serum endocan levels were measured at baseline in 40 patients with OSA and 40 healthy controls and after 3 months of continuous positive airway pressure (CPAP) treatment in the patients with OSA. All participants were evaluated by full polysomnography. Flow-mediated dilatation (FMD) and carotid intima media thickness (cIMT) were measured in all participants. Endocan levels were significantly higher in patients with OSA than in healthy controls. After adjusting confounders, endocan was a good predictor of OSA. Endocan levels correlated with OSA severity (measured by the apnea-hypopnea index [AHI]). After 3 months of CPAP treatment, endocan levels significantly decreased. Endocan levels were significantly and independently correlated with cIMT and FMD after multiple adjustments. The cIMT and FMD also had significant and independent correlation with AHI. Endocan might be a useful marker for the predisposition of patients with OSA to premature vascular disease.
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- 2016
5. Effect of CPAP on Hemocyte Profile C-reactive Protein and Fibrinogen Levels in People with Obstructive Sleep Apnea
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YILMAZ, Meltem, primary and MUTLU, Levent Cem, additional
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- 2023
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6. Cystic fibrosis diagnosed in a nineteen-year-old case.
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Yılmaz, Meltem and Mutlu, Levent Cem
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CYSTIC fibrosis diagnosis , *ASTHMA diagnosis , *BRONCHIECTASIS , *ASTHMA in children , *GENETIC disorders - Abstract
Cystic fibrosis is the most common autosomal recessive hereditary disease in white populations. It is characterized by the formation of abnormal secretions in the exocrine glands located in the sweat and salivary glands, tracheobronchial tree, large intestine, and pancreas. The severity of the clinic depends on the type of "cystic fibrosis transmembrane regulatory protein" gene mutation. Although most cases are diagnosed in infancy or childhood, some patients are also diagnosed during adolescence and adulthood. We report a case a 19-yearold patient who was followed up with a diagnosis of asthma and bronchiectasis since childhood and diagnosed with cystic fibrosis. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Expert Opinion on Practice Patterns in Mild Asthma After the GINA 2019 Updates: A Major Shift in Treatment Paradigms from a Long-Standing SABA-Only Approach to a Risk Reduction-Based Strategy with the Use of Symptom-Driven (As-Needed) Low-Dose ICS/LABA
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MUTLU, PINAR, ÖZŞEKER, ZEYNEP FERHAN, MUTLU, LEVENT CEM, ÖZTÜRK, CAN, and Aksu, Kurtulus
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Pulmonary and Respiratory Medicine ,Immunology ,Immunology and Allergy - Abstract
Purpose of Review This expert opinion, prepared by a panel of chest disease specialists, aims to review the current knowledge on practice patterns in real-life management of mild asthma and to address the relevant updates in asthma treatment by The Global Initiative for Asthma (GINA) to guide clinicians for the best clinical practice in applying these new treatment paradigms. Recent Findings On the basis of the emerging body of evidence suggesting the non-safety of short-acting beta 2-agonists (SABA)-only therapy and comparable efficacy of the as-needed inhaled corticosteroids (ICS)-formoterol combinations with maintenance ICS regimens, GINA recently released their updated Global Strategy for Asthma Management and Prevention Guide (2019). The new GINA 2019 recommendations no longer support the SABA-only therapy in mild asthma but instead includes new off-label recommendations such as symptom-driven (as-needed) low-dose ICS-formoterol and "low dose ICS taken whenever SABA is taken." The GINA 2019 asthma treatment recommendations include a major shift from long-standing approach of clinical practice regarding the use of symptom-driven SABA treatment alone in the management of mild asthma. This expert opinion supports the transition from a long-standing SABA-only approach to a risk reduction-based strategy, with the use of symptom-driven (as-needed) low-dose ICS/LABA in mild asthma patients, particularly in those with poor adherence to controller medications. The thoughtful and comprehensive approach of clinicians to these strategies is important, given that the exact far-reaching impact of this major change in management of mild asthma in the real-world settings will only be clarified over time.
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- 2022
8. Characteristics of our hypoxemic COVID-19 pneumonia patients receiving corticosteroids and mortality-associated factors
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Şengül, Aysun, primary, Mutlu, Pınar, additional, Özdemir, Özer, additional, Satıcı, Celal, additional, Turan, Muzaffer Onur, additional, Arslan, Sertaç, additional, Ogan, Nalan, additional, Ekici Ünsal, Zuhal, additional, Bozkuş, Fulsen, additional, Çapraz, Aylin, additional, Demirkol, Mustafa Asım, additional, Mutlu, Levent Cem, additional, Yıldız Gülhan, Pınar, additional, Alkılınç, Ersin, additional, Fazlıoğlu, Nevin, additional, Söyler, Yasemin, additional, Kabalak, Pınar Akın, additional, Kızılgöz, Derya, additional, Turan, Pakize Ayşe, additional, Yıldırım, Fatma, additional, Aydemir, Yusuf, additional, Şen, Nazan, additional, and Mirici, Arzu, additional
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- 2022
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9. Growth Differentiation Factor-15 Is a Novel Biomarker Predicting Acute Exacerbation of Chronic Obstructive Pulmonary Disease
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Mutlu, Levent Cem, Altintas, Nejat, Aydin, Murat, Tulubas, Feti, Oran, Mustafa, Kucukyalin, Volkan, Kaplan, Gizem, and Gurel, Ahmet
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- 2015
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10. Reduction Mammaplasty Effect on Pulmonary Function and Arterial Blood Gas in the Overweight Female
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Ceber, Mehmet, Yuksek, Adnan, Mutlu, Levent Cem, Bali, Ilhan, and Topcu, Birol
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- 2015
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11. The incidence of acute kidney injury and its association with mortality in patients diagnosed withCOVID‐19 followed up in intensive care unit
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Bayrakci, Nergiz, primary, Özkan, Gülsüm, additional, Şakaci, Murat, additional, Sedef, Samet, additional, Erdem, İlknur, additional, Tuna, Nazan, additional, Mutlu, Levent Cem, additional, Yildirim, İlker, additional, Kiraz, Nuri, additional, Erdal, Berna, additional, Gelgeç, Ebru, additional, Erer, Ayşen, additional, Saraç, Ömürhan, additional, Yavuz, Ahmet, additional, Dolap, Uysal, additional, Hayri, Uluğ Bey, additional, Kocadelioğlu, İnci, additional, and Batmaz, Emrah, additional
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- 2022
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12. A Correlation Between Quantitative Measurement Parameters of Thorax Computed Tomography and Pulmonary Function Test: A Retrospective Study
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SASANI, Hadi, primary and MUTLU, Levent Cem, additional
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- 2021
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13. The incidence of acute kidney injury and its association with mortality in patients diagnosed with COVID‐19 followed up in intensive care unit.
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Bayrakci, Nergiz, Özkan, Gülsüm, Şakaci, Murat, Sedef, Samet, Erdem, İlknur, Tuna, Nazan, Mutlu, Levent Cem, Yildirim, İlker, Kiraz, Nuri, Erdal, Berna, Gelgeç, Ebru, Erer, Ayşen, Saraç, Ömürhan, Yavuz, Ahmet, Dolap, Uysal, Hayri, Uluğ Bey, Kocadelioğlu, İnci, and Batmaz, Emrah
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COVID-19 ,ACUTE kidney failure ,INTENSIVE care units ,CHRONIC obstructive pulmonary disease - Abstract
Introduction: The kidneys are some of the most frequently affected organs during coronavirus disease 2019 (COVID‐19). This multicenter study evaluated the incidence of and risk factors for acute kidney injury (AKI) in COVID‐19 patients followed up in intensive care unit (ICU) and its association with mortality. Methods: Three hundred twenty‐eight patients diagnosed with COVID‐19 and hospitalized in ICU were included. Risk factors associated with AKI and mortality were evaluated. Results: Eighty‐eight patients (27.9%) were diagnosed with AKI. AKI was significantly associated with older age, higher baseline creatinine level, lower albumin level, and coexistence of cardiovascular disease and chronic obstructive pulmonary disease. Mortality in the entire study group was significantly associated with AKI, older age, requirement of invasive mechanical ventilation, higher neutrophil level, lower lymphocyte, and albumin levels. Conclusion: AKI is frequently seen during the course of COVID‐19 and is associated with high mortality. Identifying AKI‐related risk factors appears essential in the management of COVID‐19 patients. [ABSTRACT FROM AUTHOR]
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- 2022
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14. Relationship between serum soluble endothelial protein C receptor level and COVID-19 findings
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Bayrakci, Nergiz, primary, Ozkan, Gulsum, additional, Mutlu, Levent Cem, additional, Erdem, lknur, additional, Yildirim, Ilker, additional, Gulen, Dumrul, additional, and Celikkol, Aliye, additional
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- 2021
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15. Nitrofurantoin Kullanımına Bağlı Gelişen Akut Akciğer Toksisitesi: Bir Olgu Eşliğinde
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Yılmaz, Meltem, İşcan, Arif, and Mutlu, Levent Cem
- Abstract
5-nitrofuran türevi olan nitrofurantoin, kadın hastalarda komplikasyonsuz idrar yolu infeksiyonlarının tedavisinde ilk seçenektir. Kullanımında önemli yan etkiler bildirilmiştir ve bunlar arasında dozdan bağımsız olarak akciğer tutulumu da mevcuttur. Akut pulmoner reaksiyonlar genellikle nitrofurantoinin başlangıcından sonraki 3-8 gün içinde gelişir, ancak ilk dozdan birkaç saat ila 4 hafta sonra da ortaya çıkabilir. Bu olgu sunumunda, nitrofurantoin kullanımına bağlı, akut akciğer toksisitesi gelişen bir hasta sunulmuştur. Nitrofurantoin, a 5-nitrofuran derivative, is the first choice in the treatment of uncomplicated urinary tract infections in female patients. Significant side effects have been reported in its use, including lung involvement independent of dose. Acute pulmonary reactions usually develop within 3-8 days after start using nitrofurantoin. However, it can also occur a few hours to 4 weeks after the first dose. In this case report, a patient with acute lung toxicity due to nitrofurantoin use will be presented.
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- 2021
16. Prevalence of COPD: First epidemiological study of a large region in Turkey
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Gunen, Hakan, Hacievliyagil, Suleyman Savas, Yetkin, Ozkan, Gulbas, Gazi, Mutlu, Levent Cem, and Pehlivan, Erkan
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- 2008
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17. Association Between Serum Fetuin-A levels, Carotid Artery Stiffness, and Intima-Media Thickness in Patients With Normotensive Obstructive Sleep Apnea Syndrome
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Akyuz, Aydn, Oran, Mustafa, Alpsoy, Seref, Mutlu, Levent Cem, Akkoyun, Dursun Cayan, Guzel, Savas, and Alp, Recep
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- 2014
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18. Quantitative evaluation of computed tomography findings in patients with pulmonary embolism: the link between D-Dimer level and thrombus volume
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Sasani, Hadi, primary and Mutlu, Levent Cem, additional
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- 2021
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19. Acute Lung Toxicity Due to Nitrofurantoin Use: With A Case
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Yılmaz, Meltem, primary, İşcan, Arif, additional, and Mutlu, Levent Cem, additional
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- 2021
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20. Trakeobronkopatia Osteokondroplastika; Bir Olgu Eşliğinde.
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YILMAZ, Meltem, İŞCAN, Arif, and MUTLU, Levent Cem
- Abstract
Copyright of Medical Journal of Ankara Training & Research Hospital is the property of Medical Journal of Ankara Training & Research Hospital and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2022
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21. Carotid intima‐media thickness in chronic obstructive pulmonary disease and survival: A multicenter prospective study
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Gulbas, Gazi, primary, Turan, Onur, additional, Sarioglu, Nurhan, additional, Diken, Ozlem Ercen, additional, Ogan, Nalan, additional, Ekbic Kadioglu, Esra, additional, Kurtipek, Ercan, additional, Bozkus, Fulsen, additional, Yilmaz Demirci, Nilgün, additional, Coskun Beyan, Ayşe, additional, Mutlu, Levent Cem, additional, Sahin Duyar, Sezgi, additional, Deniz, Sami, additional, Fazlioglu, Nevin, additional, Sengul, Aysun, additional, Tanriverdi, Hakan, additional, Okutan, Oğuzhan, additional, Turan, Pakize Ayse, additional, İnonu, Handan, additional, Ortakoylu, Mediha Gonenc, additional, Lakadamyali, Huseyin, additional, Kivanc, Tulay, additional, Atli̇, Ozgur, additional, Özdemir, Ozer, additional, Filiz Koşar, A., additional, Mirici, Arzu, additional, and Suerdem, Mecit, additional
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- 2019
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22. KRONİK OBSTRÜKTİF AKCİĞER HASTALIĞINDA KAROTİS İNTİMA-MEDİA KALINLIĞI VE SAĞ KALIM ÜZERİNE ETKİSİ
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BOZKUŞ, FULSEN, TURAN, ONUR, EKBİÇ KADIOĞLU, ESRA, OGAN, NALAN, GÜLBAŞ, GAZİ, ERÇEN DİKEN, ÖZLEM, COŞKUN BEYAN, AYŞE, SÜERDEM, MECİT, MİRİCİ, NİHAL ARZU, ÖZDEMİR, ÖZER, ATLI, ÖZGÜR, KIVANÇ, TÜLAY, LAKADAMYALI, HÜSEYİN, ORTAKÖYLÜ, GÖNENÇ, İNÖNÜ KÖSEOĞLU, HANDAN, TURAN, AYŞE, OKUTAN, OĞUZHAN, TANRIVERDİ, HAKAN, ŞENGÜL, AYSUN, FAZLIOĞLU, NEVİN, DENİZ, SAMİ, SARIOĞLU, NURHAN, YILMAZ DEMİRCİ, NİLGÜN, KURTİPEK, ERCAN, ŞAHİN DUYAR, SEZGİ, and MUTLU, LEVENT CEM
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- 2017
23. Obstructive sleep apnea syndrome frequency in obese patients
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Elbuken, Gulsah, primary, Yildiz, Ismail, additional, Mutlu, Levent Cem, additional, Altintas, Nejat, additional, and Zuhur, Sayid Shafi, additional
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- 2018
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24. Kot Kumlamaya Bağlı Olarak Gelişen İki Silikozis Olgusu
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Ermiş, Hilal, Gülbaş, Gazi, Yumrutepe, Tuncay, İn, Erdal, Mutlu, Levent Cem, Günen, Hakan, and Aydın, N. Engin
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Denim Sandblasting ,Silicosis ,Kot Kumlama ,Silikozis - Abstract
Silicosis which is one of the oldest known occupational diseases is characterized by an irreversible and progressive fibrotic reaction occuring in the lungs caused by inhaling crystalline silica dust. Effective treatment for silicosis is not available. Recently, denim sandblasting especially being made in uncontrolled small-scale workplace in primitive conditions has been a striking occupation leading to silicosis . Twenty and 28 years old male patients who work in denim sandblasting for 3 years were admitted to our clinics with complaints of dyspnea and loss of weight. Chest X ray and thorax computerized tomography revealed bilateral diffuse reticulonodular and nodular opacities which were prominent in the upper and middle zones and peripheric area of pulmonary parenchyma. Restrictive disorder was observed at their pulmonary function tests. Silicosis was diagnosed by performing transbronchial biopsy in one case. Because of the similarity of complaints, radiological findings and occupational history with the former patient, no other further and invasive procedure was performed and the other patient was also diagnosed as silicosis. In developing countries in which the labor force is very cheap, silicosis becomes a public health problem in denim sandblasters and can be prevented with improvement of working conditions. We believe that further precaution must be taken to stop darkened lives while jeans is bleaching. Key words: Denim Sandblasting; Silicosis., Bilinen en eski meslek hastalıklarından biri olan silikozis, solunabilir büyüklükteki silika kristallerinin akciğer dokusunda geri dönüşümsüz ve ilerleyici bir fibrotik reaksiyon oluşturması ile karakterize tedavisi olmayan bir hastalıktır. Son yıllarda özellikle küçük ve denetimsiz atölyelerde uygunsuz koşullarda yapılan kot kumlama işi hastalığın gelişiminde farklı bir işkolu haline gelmiştir. 3 yıldır kot kumlama işinde çalışan 20 ve 28 yaşlarında iki erkek hasta, nefes darlığı ve kilo kaybı şikayetleri ile kliniğimize başvurdu. Posteroanterior akciğer grafilerinde ve toraks bilgisayarlı tomografilerinde özellikle her iki üst ve orta zonlarda ve periferik bölgelerde yoğun yerleşimli, yaygın retikülonodüler ve nodüler opasiteler izlendi. Solunum fonksiyon testlerinde restriktif tipte ventilasyon bozukluğu saptandı. Birinci olgumuza transbronşiyal biyopsi ile silikozis tanısı kondu. İkinci olgu ise ilki ile benzer yakınmaları, radyolojik bulguları ve mesleksel maruziyet öyküsü nedeniyle ileri girişimsel inceleme yapılmadan tanı aldı. İş gücünün ucuz olduğu gelişmekte olan ülkelerde kot kumlama işinde çalışanlarda bir toplum sağlığı sorunu haline gelen silikozis çalışma şartlarının düzeltilmesi ile önlenebilir. Kotlar beyazlarken kararan hayatlara son vermek için daha fazla önlem alınması gerektiği inancındayız. Anahtar kelimeler: Kot Kumlama; Silikozis.
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- 2015
25. Swyer-James (Macleod) Sendromu: Bir Olgu Nedeniyle
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Gülbaş, Gazi, Mutlu, Levent Cem, Hacıevliyagil, Süleyman Savaş, Yumrutepe, Tuncay, and Günen, Hakan
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Akciğer,Hiperlüsent,Swyer-James (Macleod) Sendromu - Abstract
Fourty two-year old male patient applied wih complaints of cough and dispnea. As there was evident hyperinflation in left lung on Posterior-Anterior (PA) chest roentgenogram, the patients was diagnosed to have Swyer-James (MacLeod) syndrome using the findings on ventilation/ perfusion scintigraphy, computerised thorax tomography and magnetic resonans (MR) angiography of thorax. We presented the case with the latest literature update as it is a rarely encountered syndrome. Key words: Lung, Hyperlucenct, Swyer-James ( Macleod ) Syndrome, 42 yaşında erkek hasta nefes darlığı ve öksürük şikayetleri ile başvurdu. Posterior Anterior (PA) akciğer grafisinde sol akciğerde belirgin havalanma artışı mevcut olan hastaya, ventilasyon- perfüzyon sintigrafisi, bilgisayarlı toraks tomografisi, toraks manyetik rezonans (MR) anjiyografi bulguları ile ‘Swyer-James (MacLeod) sendromu' tanısı konuldu. Nadir görülen bir sendrom olması nedeniyle son literatür bilgileri ışığında sunmayı uygun gördük. Anahtar Kelime:Akciğer, Hiperlüsent, Swyer-James (Macleod) Sendromu
- Published
- 2015
26. Akut Solunum Yetmezliği Olan KOAH Hastalarında İlave Oksijen Tedavisinin Hipoksi Ve Hiperkapniye Etkisi
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Mutlu, Levent Cem, Hacıevliyagil, Süleyman Savaş, Günen, Hakan, and Kızkın, Özkan
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COPD,Supplemental oxygen therapy,Hypoxemia,Hypercapnia ,KOAH,İlave oksijen tedavisi,Hipoksi,Hiperkapni - Abstract
Background: Hypoxemia and hypercapnia are frequently encountered in chronic obstructive pulmonary disease (COPD) patients with acute attack. Objectives: To investigate the effect of 2 L/min oxygen given with nasal cannula on hypoxemia and hypercapnia in COPD patients with respiratory failure. Methods: Twenty-six type I (Group I) and 36 type II (Group II) respiratory failure patients were included in the study. The patients' initial clinical and laboratory findings were obtained. Spirometric examination and arterial blood gas (ABG) analysis were repeated after the administration of optimal medical therapy including 2 L/min oxygen given with nasal cannula. The patients whose PaCO2 values increased more than 10 mmHg with the treatment were also grouped as Group III, and their comparison was made with the rest of the patients (Group IV). Results: Among the initial laboratory parameters; PaO2 was lower in Group II (p0.05). In Group III, longer disease duration and higher rate of cor pulmonale were found to be statistically significant when compared with Group IV (p, Giriş: Kronik obstruktif akciğer hastalığı (KOAH) akut atağında; hipoksemi ve hiperkapniye sıklıkla rastlanılmaktadır. Amaç: Solunum yetmezliği olan KOAH hastalarında, nazal kanül ile verilen 2 L/dk oksijenin, hipoksemi ve hiperkapniye etkisini araştırmaktır. Gereç ve Yöntem: Yirmi altı tip I (Grup I) ve 36 tip II (Grup II) solunum yetmezlikli hasta çalışmaya alındı. Hastaların başvuru klinik ve laboratuar bulguları kaydedildi. Hastalar tam tıbbi tedavi yanısıra nazal kanülle 2 L/dk ilave oksijen aldıktan sonra, solunum fonksiyon testleri ve arter kan gazı (AKG) ölçümleri tekrar edildi. Tedavi ile PaCO2 değerleri 10 mmHg'dan daha fazla yükselenler Grup III'ü oluşturdu ve geri kalan hastalarla (Grup 4) karşılaştırılmaları yapıldı. Bulgular: Başlangıç laboratuvar parametrelerinden; PaO2 Grup II'de daha düşüktü. Her iki grupta tedavi sonrası saptanan PaO2 değerlerindeki artış istatistiksel olarak anlamlıydı (p0.05). Grup 3'de Grup 4'e göre hastalık süresinin daha uzun olması ve kor pulmonale'nin daha fazla olması istatistiksel olarak anlamlı saptandı (p
- Published
- 2015
27. Pulmoner Tromboembolide Genetik Risk Faktörleri (Beş Olgu Nedeniyle)
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KIZKIN, Özkan, HACIEVLİYAGİL, S. Savaş, MUTLU, Levent Cem, GÜNEN, Hakan, and YILDIRIM, Zeki
- Abstract
Pulmonary thromboembolus is a disease with high mortality and morbidity. In addition to well known and frequent risk factors, there are some rare congenital predisposing factors. In five of 43 patients (11.6%) diagnosed as pulmonary embolus between 1998 and 2001 in our clinic we detected a genetic risk factor for venous thromboemboli. Except one patient, there were no formerly known genetic risk factor. Due to our results, it can be proposed that the genetical predisposition should be searched in patients who developed venous thromboemboli without any known risk factor. We discussed 3 patients with antiphospholipid syndrome, one patient with protein C deficiency and one patient with protein S deficiency and activated protein C resistance (APC-R), in total 5 cases, with regard to current literature. Keywords: Antiphospholipid Syndrome, Protein C Deficency, Protein S Deficency, Activated C Resistance, Pulmonary Thromboemboli, Pulmoner tromboemboli mortalite ve morbiditesi yüksek bir hastalıktır. Hastalık için bilinen ve sık görülen risk faktörlerinin yanı sıra, kongenital predispozisyon yaratan nadir durumlar da vardır. Kliniğimizde 1998-2001 yıllarında takip edilen pulmoner tromboembolili 43 hastanın beşinde (%11.6) venöz tromboemboli için genetik risk faktörü saptadık. Hastaların biri dışında hiçbirisinde daha önceden bilinen bir genetik risk faktörü yoktu. Bu yüzden; bilinen bir risk faktörü olmadığı halde, venöz tromboemboli gelişen hastalarda genetik yatkınlık sebepleri araştırılmalıdır. Biz antifosfolipid sendromlu üç, protein C eksikliği olan bir ve protein S eksikliği- aktive protein C rezistanslı (APC-R) bir olguda gelişen pulmoner tromboembolili toplam beş olguyu, ilgili literatür eşliğinde tartıştık. Anahtar kelimeler: Antifosfolipid Sendromu, Protein C Eksikliği, Protein S Eksikliği, Aktive Protein C Rezistansı, Pulmoner Tromboemboli.
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- 2015
28. Bir Olgu Nedeniyle Poland Sendromu
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Hacıevliyagil, Süleyman Savaş, Gülbaş, Gazi, Mutlu, Levent Cem, Yetkin, Özkan, Ulutaş, Hakkı, and Günen, Hakan
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Poland sendromu,Pektoralis major kası,Tek taraflı saydam akciğer. Poland Syndrome ,Poland syndrome,Absence of pectoralis major,Unilateral hyperlusensy. Poland sendromu tek taraflı pektoralis major kasının yokluğu ile karakterize konjenital - Abstract
Poland syndrome is a rarely encountered genetical disorder that is characterized with unilateral absence of pectoralis major muscle. Upper extremity deformities and anomalies in the breast, nipple and hand may accompany the syndrome. It is generally right sided and is more frequent in males. A 36 year-old male patient's PA chest X-ray who was admitted with the complaint of haemoptysis, showed rightsided hyperlucency. His chest computed tomography demonstrated Poland syndrome. This patient was presented as case report because of rarity of Poland syndrome. Key words: Poland syndrome, Absence of pectoralis major, Unilateral hyperlusensy. Poland sendromu tek taraflı pektoralis major kasının yokluğu ile karakterize konjenital, Poland sendromu pektoralis major kasının tek taraflı yokluğu ile karakterize konjenital bir sendromdur. Bu sendroma meme, el ve diğer organ anomalileri de eşlik edebilir. Genellikle sağ tarafı tutar ve erkeklerde daha sıktır. Otuzaltı yaşında hemoptizi ile başvuran erkek hastanın çekilen akciğer grafisinde sağ hemitoraksta saydamlık artışı saptandı. Bu nedenle çekilen toraks bilgisayarlı tomografisinde Poland sendromu saptandı. Bu olgu az görüldüğü ve radyolojik özellikleri nedeniyle sunulmuştur. Anahtar kelimeler: Poland sendromu, Pektoralis major kası, Tek taraflı saydam akciğer. Poland Syndrome
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- 2015
29. Tekirdağ’da Tüberkülozun Yıllar İçindeki Değişimi
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Güneş, Hayati, Altın, Remzi, Mutlu, Levent Cem, Doğan, Mustafa, Oran, Mustafa, Işık, Salman, Salt, Gürdal, Kaya, Ayşe Demet, and Topçu, Birol
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antitüberküloz ajanlar ,Tüberküloz ,antibiyotik direnci ,antibiotic resistance ,multidrug resistance ,Incidence ,Tuberculosis ,insidans ,çoklu ilaç direnci ,antitubercular agents - Abstract
Amaç Dünya Sağlık Örgütü tarafından tüm dünyada hesaplanan tüberküloz (TB) insidansı 100.000'de 128'dir. TB kontrolünün ana prensipleri erken tanı ve tedavi, bunu takiben de hastaların direkt gözlemsel tedavisidir. Bu çalışmanın amacı, 2007-2011 yılları arasında Tekirdağ’da tüberküloz verilerindeki değişimin analizini yapmaktı. Materyal ve Metod Tekirdağ il sınırları içinde bulunan Tekirdağ ve Çorlu Verem savaş dispanserlerinden elde edilen veriler birer yıllık kategorilere ayrıldı. Hastalar, yaş gruplarına göre 0-14, 15-24, 25-44, 45-64, 65 ve Üzeri olmak Üzere 5 gruba ayrıldı ve vaka bildirim oranları tüm gruplarda analiz edildi. Hastalar, tutulan organa göre 2 gruba ayrıldı: Pulmoner (smear/kültür pozitif =PSP ve smear/kültür negatif/bilinmeyen =PSB/N) ve ekstrapulmoner. Kültürde üremiş ve dirençli olduğundan şüphelenilen M. Tuberculosis suşlarına major ilaçlar olan izoniazid (INH), rifampisin, etambutol ve streptomisine karşı duyarlılık testi uygulandı. INH ve rifampisine dirençli suşlar çoklu ilaca dirençli tüberküloz olarak kabul edildi (ÇİD-TB). Bulgular Toplam 162.291 hasta muayene edildi ve bunlardan 1311 (%0,8)’i TB hastası olarak değerlendirildi. Vaka bildirim oranlarının yıllara gore dağılımı 2007 ile 2011 arasında sırasıyla %44,6, %34,6, %33,4 ve %28,6 idi. Pulmoner ve ekstrapulmoner TB oranları sırasıyla %74,5 (%46 PSP ve %28,5 PSN/B) ve %25,5 idi. Ekstrapulmoner tüberküloz oranları erkekler ve kadınlarda sırasıyla %42,3 ve %17,6 idi. INH, rifampisin, etambutol ve streptomisine direnöoranları sırasıyla %21,6, %8,8, %1,6 ve %6,4 idi. ÇİD-TB oranı %6,4 olarak tespit edildi. Sonuç Doğrudan gözetimli tedavinin sistematik uygulanması tüberküloz insidansının düşmesinde önemli rol oynar. Bölgemizde tüberküloz oranları türkiye ortalamasının üzerinde olduğundan tarama ve takip prosedürleri daha sıkı ve düzenli olarak uygulanmalıdır. Aim The incidence rate of tuberculosis (TB) is estimated by the World Health Organization as 128/100.000 worldwide. The main principles of TB control are early case detection and diagnosis, followed by directly observed treatment of patients. The aim of this study was to analyse the dynamics of TB between 2007 and 2011 in Tekirdağ. Material and Methods Data were obtained from TB dispensaries and separated into oneyear categories. Case notification rates were analysed by different age groups (0–14, 15–24, 25–44, 45–64, 65 and above). The patients were divided into two groups according to involved organs: pulmonary (smear/culture positive=PSP and smear/culture negative/unknown=PSN/U) and extrapulmonary. Antibiotic susceptibility tests to major antituberculosis drugs were performed on M. tuberculosis strains that were grown in culture and suspected of being resistant. Resistance to both INH and rifampicin were accepted as multiple drug resistance tuberculosis (MDR-TB). Results A total of 162.291 patients were examined, and out of this population, 1311 (0.8%) tuberculosis patients were evaluated. The distribution of case notification rates by year were 44.6%, 34.6%, 33.4%, 28.6%, and 27.6%from 2007 to 2011, respectively. Pulmonary and extrapulmonary TB rates were 74.5%(46.0%PSP and 28.5%PSN/U) and 25.5%, respectively. Extrapulmonary TB rates were 42.3% and 17.6% in men and women, respectively. Resistance rates against INH, rifampicin, ethambutol, and streptomycin were 21.6%, 8.8%, 1.6%, and 6.4%, respectively. The MDR-TB rate was 6.4%. Conclusion Systematic implementation of directly observed treatment programs plays an important role in decreasing TB incidence. Because the TB rates in our region are above the average for Turkey, screening and follow-up procedures must be conducted more stringently and regularly.
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- 2015
30. Desquamative interstitial pneumonia: Risk factors, laboratory and bronchoalveolar lavage findings, radiological and histopathological examination, clinical features, treatment and prognosis.
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Diken, Özlem Erçen, Şengül, Aysun, Beyan, Ayşe Coşkun, Ayten, Ömer, Mutlu, Levent Cem, and Okutan, Oğuzhan
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IDIOPATHIC pulmonary fibrosis ,PULMONARY fibrosis ,IDIOPATHIC interstitial pneumonias ,BRONCHOALVEOLAR lavage ,PULMONARY alveolar proteinosis ,PNEUMONIA ,PULMONARY function tests - Abstract
Desquamative interstitial pneumonia is a type of smoking-associated major idiopathic interstitial pneumonia, which is characterized by accumulation of alveolar macrophages in alveolar lumens and septa and develops secondary to mainly active or passive exposure to cigarette smoke. Desquamative interstitial pneumonia mostly occurs in male smokers in association with non-specific symptoms responsive to steroid therapy and has a better prognosis than usual interstitial pneumonia. To date, no large-scale clinical studies have been performed on desquamative interstitial pneumonia patients. Factors responsible for the scarcity of data on the clinical course of this condition include the retrospective nature of the available information as well as its rare occurrence. Despite this, a general consensus exists as to the nature of its symptoms, association with smoking, age and gender distribution, findings of respiratory function tests, steroid responsivity and mortality. The objective of the present review article was to report on desquamative interstitial pneumonia and to describe its etiology, risk factors and clinical features, as well as the laboratory, bronchoalveolar lavage, radiological and histopathological findings, and the treatment and prognosis of affected patients. [ABSTRACT FROM AUTHOR]
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- 2019
31. Tekirdağ İlinde 2007-2011 Yılları Arası Tüberkülozun Mevsimselliği
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Mutlu, Levent Cem, Altın, Remzi, Güneş, Hayati, Doğan, Mustafa, Oran, Mustafa, Işık, Salman, Salt, Gürdal, Kaya, Ayşe Demet, and Topçu, Birol
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Tüberküloz ,seasonality ,Incidence ,Tuberculosis ,insidans ,mevsimsellik - Abstract
Amaç Pek çok solunumsal enfeksiyonun mevsimsel değişkenlik gösterdiği bilinmektedir. Bununla birlikte pek çok çalışmada, diğer solunumsal enfeksiyonlardan farklı olarak tüberküloz tanısı alan hasta sayısı yaz aylarında artış göstermektedir ve altta yatan mekanizma tam olarak açıklanamamıştır. Çalışmamızda, Tekirdağ ilinde tüberküloz tanısının mevsimsellik gösterip göstermediğinin araştırılması hedeflenmiştir. Materyal ve Metot Bu amaçla Tekirdağ Verem Savaş Dispanserlerinde kayıtlı olan hastaların dosyaları geriye dönük olarak taranarak, Ocak 2007 ile Aralık 2011 tarihleri arasında 1311 hastaya tüberküloz teşhisi konulmuş olduğu tespit edilmiştir. Bulgular Tüberküloz tanısının % 28,4 oranıyla en sık yaz aylarında konulmuş olduğu saptanmıştır. Sonuç Sonuç olarak farklı ülkelerde yapılan çalışmalara benzer şekilde Tekirdağ’da da tüberkülozun mevsimsellik gösterdiği tespit edilmiştir. Hastalığın daha iyi kontrolünü sağlamada altta yatan mekanizmaları açıklayacak prospektif çalışmalara ihtiyaç olduğu kanısına varılmıştır. Aim It is well known that the incidence of many respiratory infections shows seasonal variability. Unlike other respiratory infections, in many studies tuberculosis (TB) diagnoses increase in summer and the mechanism underlying this fluctuation remains unknown. We aimed to examine whether TB has an annual seasonal pattern in Tekirdağ. Materials and Methods Data were obtained from TB dispensaries in Tekirdağ retrospectively. There were 1311 cases of TB notified between January 2007 and December 2011. TB notifications show a seasonal pattern, with a peak in spring and summer, which is present in both pulmonary and extra pulmonary tuberculosis. Results TB notification was found highest in summer with the value of 28,4 %. Conclusion TB incidence in Tekirdağ showed seasonality like previous studies held in different countries. There is a need for large longitudinal studies to clarify the underlying mechanisms that may provide a better disease control.
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- 2014
32. Assesment of palliative care in lung cancer in Turkey (ASPECT study)
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Bulbul, Yilmaz, primary, Ozlu, Tevfik, additional, Arinc, Sibel, additional, Ozyurek, Berna A., additional, Gunbatar, Hulya, additional, Senturk, Aysegul, additional, Bahadir, Ayse, additional, Ozcelik, Melike, additional, Yilmaz, Ufuk, additional, Akbay, Makbule Ozlem, additional, Saglam, Leyla, additional, Kilic, Talat, additional, Kirkil, Gamze, additional, Ozcelik, Neslihan, additional, Tatar, Dursun, additional, Baris, Serap Argun, additional, Yavsan, Mehmet, additional, Sen, Hatice Selimoglu, additional, Berk, Serdar, additional, Acat, Murat, additional, Cakmak, Gulfidan, additional, Yumuk, Perran Fulden, additional, Intepe, Yavuz Selim, additional, Toru, Umran, additional, Ayik, Sibel O., additional, Basyigit, Ilknur, additional, Ozkurt, Sibel, additional, Mutlu, Levent Cem, additional, Yasar, Zehra Asuk, additional, Esme, Hidir, additional, Erol, Muharrem, additional, Oruc, Ozlem, additional, Erdogan, Yurdanur, additional, Asker, Selvi, additional, Ulas, Arife, additional, Erol, Serhat, additional, Kerget, Bugra, additional, Erbaycu, Ahmet Emin, additional, Teke, Turgut, additional, Besiroglu, Mehmet, additional, Can, Huseyin, additional, and Talay, Fahrettin, additional
- Published
- 2015
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33. General characteristics and therapeutic options in lung cancer in Turkey
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Ozlu, Tevfik, primary, Bulbul, Yilmaz, additional, Arinc, Sibel, additional, Ozyurek, Berna A., additional, Gunbatar, Hulya, additional, Senturk, Aysegul, additional, Bahadir, Ayse, additional, Ozcelik, Melike, additional, Yilmaz, Ufuk, additional, Akbay, Makbule Ozlem, additional, Saglam, Leyla, additional, Kilic, Talat, additional, Kirkil, Gamze, additional, Ozcelik, Neslihan, additional, Tatar, Dursun, additional, Baris, Serap Argun, additional, Yavsan, Mehmet, additional, Sen, Hatice Selimoglu, additional, Berk, Serdar, additional, Acat, Murat, additional, Cakmak, Gulfidan, additional, Yumuk, Perran Fulden, additional, Intepe, Yavuz Selim, additional, Toru, Umran, additional, Ayik, Sibel O., additional, Basyigit, Ilknur, additional, Ozkurt, Sibel, additional, Mutlu, Levent Cem, additional, Yasar, Zehra Asuk, additional, Esme, Hidir, additional, Erol, Muharrem, additional, Oruc, Ozlem, additional, Erdogan, Yurdanur, additional, Asker, Selvi, additional, Ulas, Arife, additional, Erol, Serhat, additional, Kerget, Bugra, additional, Erbaycu, Ahmet Emin, additional, Teke, Turgut, additional, Besiroglu, Mehmet, additional, Can, Huseyin, additional, and Talay, Fahrettin, additional
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- 2015
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34. The Effect of Respiratory Functions and Pulmonary Artery Pressure on Right and Left Ventricular Diastolic Function
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Alpsoy, Şeref, Akyüz, Aydın, Akkoyun, Dursun Çayan, Oran, Mustafa, Mutlu, Levent Cem, Topçu, Birol, and Yalçın, Banu Çiçek
- Subjects
Solunum Sistemi ,cardiovascular system ,Kalp ve Kalp Damar Sistemi ,cardiovascular diseases ,Genel ve Dahili Tıp ,circulatory and respiratory physiology ,respiratory tract diseases - Abstract
Giriş: Bu çalışmada, kronik obstrüktif akciğer hastalığı (KOAH) olan kişilerde konvansiyonel ve doku Doppler ekokardiyografi yle sağ ve sol ventrikül diyastolik fonksiyonlarını değerlendirmeyi, solunum fonksiyonları ve pulmoner arter basıncının diyastolik fonksiyonlar üzerine etkisini araştırmayı amaçladık. Hastalar ve Yöntem: KOAH'lı 60 hasta ve 40 sağlıklı birey iki boyutlu, M-mode, konvansiyonel ve doku Doppler ekokardiyografi yle değerlendirildi. Tüm bireylere solunum fonksiyon testleri (SFT) ile birinci saniyedeki zorlu ekspiratuvar volüm [forced expiratory volume in 1 second (FEV)] ve zorlu vital kapasite [forced vital capacity (FVC)] tayini yapıldı. FEV, FEV/FVC ve ortalama pulmoner arter basıncı (OPAB) ile diyastolik fonksiyon parametreleri arasındaki ilişkiyi araştırmak için korelasyon ve regresyon analizi yapıldı.Bulgular: KOAH grubunda sağ ventrikül çapı ve serbest duvar kalınlığı daha fazla, triküspit E ve E/A, triküspit lateral annulus E' ve E'/A', mitral annulus septal E' ve E'/A' değerleri daha düşük, mitral E/mitral annulus septal E' değeri daha yüksekti (p değerleri < 0.05). FEVile triküspit lateral annulus E' ve E'/A' arasında pozitif korelasyon vardı. Triküspit E/A, triküspit lateral annulus E' ve E'/A', mitral annulus septal E' ve E'/A' değerleriyle FEV/FVC arasında pozitif, OPAB arasında negatif korelasyon vardı. Mitral E/mitral annulus septal E'değeriyle FEV/FVC arasında negatif, OPAB ile pozitif korelasyon vardı. FEV/FVC, triküspit lateral annulus E' ve E'/A', mitral annulus septal E' ve E'/A' için belirleyiciydi.Sonuç: KOAH hastalarında sağ ve sol ventrikül diyastolik fonksiyonları bozulmaktadır. Bu hastalarda, kronik hipoksi ve pulmoner basınç artışı sağ ve sol ventrikül diyastolik fonksiyon bozukluğu gelişmesinde etkili faktörlerdir. Introduction: The aim of the study was to evaluate of biventricular diastolic function and to investigate the effect of pulmonary function and pulmonary artery pressure on diastolic functions in people with chronic obstructive pulmonary disease (COPD).Patients and Methods: Sixty patients with COPD and 40 healthy individuals were assessed by echocardiography and pulmonary function tests (PFTs). Forced expiratory volume in one second (FEV) and forced vital capacity (FVC) were determined. Correlation and regression analysis were performed to investigate the relationship between FEV, FEV/FVC, mean pulmonary artery pressure (MPAB) and diastolic function parameters. Results: Right ventricular diameter and free wall thickness and mitral E/mitral septal annulus E' were higher whereas tricuspid E and E/A, tricuspid lateral annulus E' and E'/A', mitral septal annulus E' and E'/A' values were lower in the COPD group (all p values of < 0.05). FEV was positively correlated with lateral tricuspid annulus E' and E'/A'. Tricuspid E/A, tricuspid lateral annulus E' and E'/A', mitral septal annulus E' and E'/A' values were positively correlated with FEV/FVC, whereas negatively correlated with MPAB. Mitral E/mitral annulus septal E' was negatively correlated with FEV/FVC, and positively correlated with MPAB. FEV/FVC was decisive for tricuspid lateral annulus E' and E'/A', mitral annulus septal E' and E'/A' values.Conclusion: Right and left ventricular diastolic function are impaired in patients with COPD. Chronic hypoxia and increased pulmonary pressure are important factors in the development of diastolic dysfunction in patients with COPD.
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- 2013
35. Kronik obstrüktif akciğer hastalığında genetik risk faktörleri
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Mutlu, Levent Cem, Gülbaş, Gazi, and Günen, Hakan
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Solunum Sistemi - Abstract
Kronik obstrüktif akciğer hastalığı (KOAH) oluşumunda genetik faktörlerin rolünün önemli olduğu fikri genel olarak kabul edilmektedir. Bununla birlikte, yarım asırdan uzun süredir yapılan birçok çalışmadan ?-1 antitripsin eksikliğinin tek başına KOAHa yol açabileceği bilgisi dışında kesin bir sonuç elde edilememiştir. Elimizdeki veriler ışığında, birçok gen bozuklukları arasındaki etkileşimlerin üstüne eklenen sigara dumanı gibi çevresel faktörlerin KOAH oluşumdan sorumlu olduğu söylenebilir. Şüphesiz gelecekte de KOAH oluşumunda genetik risk faktörleri, üzerinde en fazla çalışılan konulardan biri olmaya devam edecektir. The role of genetic factors in development of chronic obstructive pulmonary disease (COPD) is accepted in general. However, other than α-1 antitrypsin deficiency which alone can lead to COPD, the studies performed longer than half a century did not yield any certain result on the genetics of COPD. Regarding the data available, it can be said that addition of environmental factors like cigarette smoking on interrelations between genetic abnormalities are responsible for COPD development. No doubt that the role of genetics on COPD development will continue to be one of the important research issues in future too.
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- 2012
36. Kot kumlamaya bağlı olarak gelişen iki silikozis olgusu
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Ermiş, Hilal, Gülbaş, Gazi, Yumrutepe, Tuncay, İn, Erdal, Mutlu, Levent Cem, Günen, Hakan, and Aydın, N. Engin
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Genel ve Dahili Tıp - Abstract
Bilinen en eski meslek hastalıklarından biri olan silikozis, solunabilir büyüklükteki silika kristallerinin akciğer dokusunda geri dönüşümsüz ve ilerleyici bir fibrotik reaksiyon oluşturması ile karakterize tedavisi olmayan bir hastalıktır. Son yıllarda özellikle küçük ve denetimsiz atölyelerde uygunsuz koşullarda yapılan kot kumlama işi hastalığın gelişiminde farklı bir işkolu haline gelmiştir. 3 yıldır kot kumlama işinde çalışan 20 ve 28 yaşlarında iki erkek hasta, nefes darlığı ve kilo kaybı şikayetleri ile kliniğimize başvurdu. Posteroanterior akciğer grafilerinde ve toraks bilgisayarlı tomografilerinde özellikle her iki üst ve orta zonlarda ve periferik bölgelerde yoğun yerleşimli, yaygın retikülonodüler ve nodüler opasiteler izlendi. Solunum fonksiyon testlerinde restriktif tipte ventilasyon bozukluğu saptandı. Birinci olgumuza transbronşiyal biyopsi ile silikozis tanısı kondu. İkinci olgu ise ilki ile benzer yakınmaları, radyolojik bulguları ve mesleksel maruziyet öyküsü nedeniyle ileri girişimsel inceleme yapılmadan tanı aldı. İş gücünün ucuz olduğu gelişmekte olan ülkelerde kot kumlama işinde çalışanlarda bir toplum sağlığı sorunu haline gelen silikozis çalışma şartlarının düzeltilmesi ile önlenebilir. Kotlar beyazlarken kararan hayatlara son vermek için daha fazla önlem alınması gerektiği inancındayız. Silicosis which is one of the oldest known occupational diseases is characterized by an irreversible and progressive fibrotic reaction occuring in the lungs caused by inhaling crystalline silica dust. Effective treatment for silicosis is not available. Recently, denim sandblasting especially being made in uncontrolled small-scale workplace in primitive conditions has been a striking occupation leading to silicosis . Twenty and 28 years old male patients who work in denim sandblasting for 3 years were admitted to our clinics with complaints of dyspnea and loss of weight. Chest X ray and thorax computerized tomography revealed bilateral diffuse reticulonodular and nodular opacities which were prominent in the upper and middle zones and peripheric area of pulmonary parenchyma. Restrictive disorder was observed at their pulmonary function tests. Silicosis was diagnosed by performing transbronchial biopsy in one case. Because of the similarity of complaints, radiological findings and occupational history with the former patient, no other further and invasive procedure was performed and the other patient was also diagnosed as silicosis. In developing countries in which the labor force is very cheap, silicosis becomes a public health problem in denim sandblasters and can be prevented with improvement of working conditions. We believe that further precaution must be taken to stop darkened lives while jeans is bleaching.
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- 2011
37. Effect of CPAP on New Endothelial Dysfunction Marker, Endocan, in People With Obstructive Sleep Apnea
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Altintas, Nejat, primary, Mutlu, Levent Cem, additional, Akkoyun, Dursun Cayan, additional, Aydin, Murat, additional, Bilir, Bulent, additional, Yilmaz, Ahsen, additional, and Malhotra, Atul, additional
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- 2015
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38. TIME ELAPSED TILL DIAGNOSIS OF EXTRA-PULMONARY TUBERCULOSIS
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HACIEVLİYAGİL, Süleyman Savaş, MUTLU, Levent Cem, DURAN, Mustafa, KIZKIN, Özkan, TEMİZ, Şahin, EVLİYAOĞLU, Ercüment, ARICA, Zeynep Kazgan, TÜRK, Ali Önder, ŞENOĞLU, Aydın, GÜLBAŞ, Gazi, YETKİN, Özkan, and GÜNEN, Hakan
- Subjects
Akciğer dışı tüberküloz,tüberküloz plörezi,tüberküloz lenfadenit,tanı süresi ,Extra-Pulmonary Tuberculosis,tuberculous pleuritis,tuberculous lymphadenitis,diagnosis time - Abstract
Akciğer Dışı Tüberküloz (ADT), akciğer parankimi dışında gelişen tüberküloz olgularını içermektedir. Tüberküloz hastalarında sıklıkla tanıda gecikmeler görülmektedir. Bu çalışmada Malatya Verem Savaş Dispanserleri ve İnönü Üniversitesi Tıp Fakültesine başvuran ADT hastalarının özellikleri, dağılımları ve tanı konulma süreleri incelendi. Çalışmaya 150 ADT hastası alındı. Tüberküloz plörezi (n=58) ve tüberküloz lenfadenit (n=45) en çok saptanan ADT tipleriydi. ADT hastalarının yaş ortalaması 37.3±15.7 yıl olarak saptandı. Hastaların 83'ü (%55.3) kadın, 67'si (%44.7) erkekti. Tüberküloz plörezi erkeklerde (32/26), tüberküloz lenfadenit kadınlarda (33/12) daha sık gözlendi. Hastaların şikayetlerinin başlangıcı ile ADT tanısı konulması arasındaki süre ortalama 102.7±141.0 gün olup, ortalama tanı süreleri tüberküloz lenfadenit için 128.6±120.7 gün, tüberküloz plörezi için 56.2±45.7 gün olarak saptandı. En kısa tanı süresi miliyer tüberküloz ve tüberküloz menenjitin yer aldığı progresif ADT'de (29.8±33.1 gün) saptanırken, en uzun tanı süresi genitoüriner tüberkülozda (216.7±330.0 gün) bulundu. ADT'li hastaların ortalama 24.4±27.1 gün süre ile hastaneye yattıkları saptandı. Gastrointestinal tüberküloz hastaları en uzun (43.0±67.7 gün), tüberküloz lenfadenit hastaları en kısa süre (12.8±3.9 gün) hastaneye yatmışlardı. Sonuç olarak, ADT hastalarında tanı konma süresi uzun bulundu. ADT tanısının konmasında hastaların anamnezlerinde tüberküloz öyküsünün ve temasının olup olmadığının sorgulanması önemlidir. Ülkemizde tüberküloz sıklığı da göz önüne alınarak, hangi organ hastalığı olursa olsun, tanı konulamayan olgularda tüberküloza yönelik incelemelerin mutlaka yapılması gerektiğini düşünüyoruz., Extra-Pulmonary Tuberculosis (EPT) includes the tuberculosis cases other than the ones developed in the pulmonary parenchyma. The delay in the diagnosis of EPT cases is frequently encountered. In this study, time elapsed till the diagnosis, patient characteristics and their distribution were investigated in EPT patients admitted to Malatya Tuberculosis Dispensaries and Inonu University Faculty of Medicine. One-hundred and fifty EPT patients were included in the study. The most frequent EPT cases were tuberculous pleuritis (n=58) and tuberculous lymphadenitis (n=45). Mean age of the EPT patients was 37.3±15.7 years. Eighty-three of the patients (55.3%) were female, 67 of them (44.7%) were male. While tuberculous pleuritis was more frequent in male patients (32/26), tuberculous lymphadenitis was more frequent in female patients (33/12). While the average time elapsed till the diagnosis of all EPT cases since the beginning of symptoms was 102.7±141.0 days, it was 128.6±120.7 days and 56.2±45.7 days for tuberculous lymphadenitis and tuberculous pleuritis respectively. The shortest diagnosis time was for progressive tuberculosis which included miliary and meningitis tuberculosis (29.8±33.1 days), and the longest diagnosis time was for genitourinary tuberculosis (216.7±330.0 days). The mean hospitalization period for all EPT cases was 24.4±27.1 days. While the longest hospitalization period was found in patient groups with gastrointestinal tuberculosis (43.0±67.7 days respectively), the shortest hospitalization period was found in the patient group with tuberculous lymphadenitis (12.8±3.9 days). In conclusion, time elapsed to diagnose the EPT was found considerably longer than expected. Asking questions for the history of any tuberculosis and the history of close contact is important in the diagnosis of EPT. We think that, considering the high incidence of tuberculosis in our country, investigations for tuberculosis should be included in the diagnosis algorithm of the diseases involving any organ, if undiagnosed otherwise.
- Published
- 2006
39. Serum fetuin-A levels are associated with carotid intima–media thickness in patients with normotensive chronic obstructive pulmonary disease
- Author
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Alpsoy, Seref, primary, Akyuz, Aydın, additional, Mutlu, Levent Cem, additional, Oran, Mustafa, additional, Akkoyun, Dursun Cayan, additional, Topcu, Birol, additional, Degirmenci, Hasan, additional, and Guze, Savas, additional
- Published
- 2014
- Full Text
- View/download PDF
40. Prevalence of smoking and factors affecting smoking behaviour during pregnancy: A sample from Tekirdağ/Gebelikte sigara içme prevalansı ve sigara içme davranışını etkileyen etmenler: Tekirdağ örneği
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Mutlu, Levent Cem, primary and Varol Saraçoğlu, Gamze, additional
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- 2014
- Full Text
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41. Endobronchial tuberculosis in a patient with bronchial asthma treated with high doses of inhaled corticosteroids
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Mutlu, Levent Cem, Ermiş, Hilal, and Çakır, Münire
- Published
- 2003
42. The Effect of Respiratory Functions and Pulmonary Artery Pressure on Right and Left Ventricular Diastolic Function
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Alpsoy, Şeref, primary, Akyüz, Aydın, additional, Çayan Akkoyun, Dursun, additional, Oran, Mustafa, additional, Mutlu, Levent Cem, additional, Topçu, Birol, additional, Değirmenci, Hasan, additional, and Yalçın, Banu Çiçek, additional
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- 2013
- Full Text
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43. Childhood asthma and vitamin D deficiency in Turkey: is there cause and effect relationship between them?
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Uysalol, Metin, primary, Mutlu, Levent Cem, additional, Saracoglu, Gamze Varol, additional, Karasu, Erkut, additional, Guzel, Savas, additional, Kayaoglu, Semra, additional, and Uzel, Nedret, additional
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- 2013
- Full Text
- View/download PDF
44. Association Between Serum Fetuin-A levels, Carotid Artery Stiffness, and Intima–Media Thickness in Patients With Normotensive Obstructive Sleep Apnea Syndrome
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Akyuz, Aydın, primary, Oran, Mustafa, additional, Alpsoy, Seref, additional, Mutlu, Levent Cem, additional, Akkoyun, Dursun Cayan, additional, Guzel, Savas, additional, and Alp, Recep, additional
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- 2013
- Full Text
- View/download PDF
45. Sarcoidosis: A 16 Year-Old Case Report
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Nalbantoglu, Burcin, primary, Mutlu, Levent Cem, additional, Uysalol, Metin, additional, and Karasu, Erkut, additional
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- 2013
- Full Text
- View/download PDF
46. Genetic Risk Factors in Chronic Obstructive Pulmonary Disease
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Mutlu, Levent Cem, primary, Gulbas, Gazi, additional, and Gunen, Hakan, additional
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- 2012
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47. Sarkoidoz: On Altı Yaşında Bir Vaka Sunumu.
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Nalbantoğlu, Burçin, Mutlu, Levent Cem, Uysalol, Metin, and Karasu, Erkut
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- *
SARCOIDOSIS diagnosis , *SARCOIDOSIS treatment , *ERYTHROCYTES , *METHOTREXATE , *ETIOLOGY of diseases , *STEROIDS - Abstract
Sarcoidosis is a multisystemic, granulomatous disease with an unknown etiology. Although granulomas suggest an etiology related to infectious, and organic agents, their etiologies are still unknown. A 16 year-old girl referred with complaints of cough, malaise, and painful lesions on legs lasting for 4 months. On physical examination, no pathological sign was observed, except an erythema nodosum-like purple lesion, the largest one being 5 cm in diameter was detected on the tibial region. Erythrocyte sedimentation rate was 60/1 hour and CRP 15.66 mg/L. Angiotension converting enzyme level was elevated. High resolution thoracal CT results were reported as multiple mediastinal lymphadenopaties and micronodular parenchymal infiltrations at right middle and lower lobes. In biopsy, taken during bronchoscopy, granulamatous lesions were observed. Patient was suggestively diagnosed as sarcoidosis with these findings and followed up without treatment because of relatively lesser severity of these findings. Sarcoidosis is a rare disease of childhood, and can spontaneously resolve or become chronic. Follow-up of the patients with physical examination and respiratory function tests are necessary. Steroids or methotrexate can be used for the treatment according to the clinical severity of the disease, but results are controversial. Since it a rarely seen condition, we want to emphasize the importance of sarcoidosis and review the literature. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
48. Sarkoidoz: On Altı Yaşında Bir Vaka Sunumu.
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Nalbantoğlu, Burçin, Mutlu, Levent Cem, Uysalol, Metin, and Karasu, Erkut
- Subjects
- *
SARCOIDOSIS diagnosis , *SARCOIDOSIS treatment , *GRANULOMA , *BRONCHOSCOPY - Abstract
Sarcoidosis is a multisystemic, granulomatous disease with an unknown etiology. Although granulomas suggest an etiology related to infectious, and organic agents, their etiologies are still unknown. A 16 year-old girl referred with complaints of cough, malaise, and painful lesions on legs lasting for 4 months. On physical examination, no pathological sign was observed, except an erythema nodosum-like purple lesion, the largest one being 5 cm in diameter was detected on the tibial region. Erythrocyte sedimentation rate was 60/1 hour and CRP 15.66 mg/L. Angiotension converting enzyme level was elevated. High resolution thoracal CT results were reported as multiple mediastinal lymphadenopaties and micronodular parenchymal infiltrations at right middle and lower lobes. In biopsy, taken during bronchoscopy, granulamatous lesions were observed. Patient was suggestively diagnosed as sarcoidosis with these findings and followed up without treatment because of relatively lesser severity of these findings. Sarcoidosis is a rare disease of childhood, and can spontaneously resolve or become chronic. Follow-up of the patients with physical examination and respiratory function tests are necessary. Steroids or methotrexate can be used for the treatment according to the clinical severity of the disease, but results are controversial. Since it a rarely seen condition, we want to emphasize the importance of sarcoidosis and review the literature. [ABSTRACT FROM AUTHOR]
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- 2011
- Full Text
- View/download PDF
49. Uyku evrelemesinde manuel (görsel) evreleme ile otomatik evrelemenin uyumu.
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ÖZTÜRK, Önder, MUTLU, Levent Cem, SAĞCAN, Gülseren, DENİZ, Yüksel, and ÇUHADAROĞLU, Çağlar
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- 2009
50. The Effect of Supplemental Oxygen on Hypoxemia and Hypercapnia in COPD Patients with Acute Respiratory Failure.
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Mutlu, Levent Cem, Hacievliyagi, Süleyman Savaş, Günen, Hakan, and Kizkin, Özkan
- Published
- 2006
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