262 results on '"Muthusamy, R"'
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2. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
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Naghavi, M, Ong, K, Aali, A, Ababneh, H, Abate, Y, Abbafati, C, Abbasgholizadeh, R, Abbasian, M, Abbasi-Kangevari, M, Abbastabar, H, Abd ElHafeez, S, Abdelmasseh, M, Abd-Elsalam, S, Abdelwahab, A, Abdollahi, M, Abdollahifar, M, Abdoun, M, Abdulah, D, Abdullahi, A, Abebe, M, Abebe, S, Abedi, A, Abegaz, K, Abhilash, E, Abidi, H, Abiodun, O, Aboagye, R, Abolhassani, H, Abolmaali, M, Abouzid, M, Aboye, G, Abreu, L, Abrha, W, Abtahi, D, Abu Rumeileh, S, Abualruz, H, Abubakar, B, Abu-Gharbieh, E, Abu-Rmeileh, N, Aburuz, S, Abu-Zaid, A, Accrombessi, M, Adal, T, Adamu, A, Addo, I, Addolorato, G, Adebiyi, A, Adekanmbi, V, Adepoju, A, Adetunji, C, Adetunji, J, Adeyeoluwa, T, Adeyinka, D, Adeyomoye, O, Admass, B, Adnani, Q, Adra, S, Afolabi, A, Afzal, M, Afzal, S, Agampodi, S, Agasthi, P, Aggarwal, M, Aghamiri, S, Agide, F, Agodi, A, Agrawal, A, Agyemang-Duah, W, Ahinkorah, B, Ahmad, A, Ahmad, D, Ahmad, F, Ahmad, M, Ahmad, S, Ahmad, T, Ahmadi, K, Ahmadzade, A, Ahmed, A, Ahmed, H, Ahmed, L, Ahmed, M, Ahmed, S, Ajami, M, Aji, B, Akara, E, Akbarialiabad, H, Akinosoglou, K, Akinyemiju, T, Akkaif, M, Akyirem, S, Al Hamad, H, Al Hasan, S, Alahdab, F, Alalalmeh, S, Alalwan, T, Al-Aly, Z, Alam, K, Alam, M, Alam, N, Al-amer, R, Alanezi, F, Alanzi, T, Al-Azzam, S, Albakri, A, Albashtawy, M, Albataineh, M, Alcalde-Rabanal, J, Aldawsari, K, Aldhaleei, W, Aldridge, R, Alema, H, Alemayohu, M, Alemi, S, Alemu, Y, Al-Gheethi, A, Alhabib, K, Alhalaiqa, F, Al-Hanawi, M, Ali, A, Ali, L, Ali, M, Ali, R, Ali, S, Alicandro, G, Alif, S, Alikhani, R, Alimohamadi, Y, Aliyi, A, Aljasir, M, Aljunid, S, Alla, F, Allebeck, P, Al-Marwani, S, Al-Maweri, S, Almazan, J, Al-Mekhlafi, H, Almidani, L, Almidani, O, Alomari, M, Al-Omari, B, Alonso, J, Alqahtani, J, Alqalyoobi, S, Alqutaibi, A, Al-Sabah, S, Altaany, Z, Altaf, A, Al-Tawfiq, J, Altirkawi, K, Aluh, D, Alvis-Guzman, N, Alwafi, H, Al-Worafi, Y, Aly, H, Aly, S, Alzoubi, K, Amani, R, Amare, A, Amegbor, P, Ameyaw, E, Amin, T, Amindarolzarbi, A, Amiri, S, Amirzade-Iranaq, M, Amu, H, Amugsi, D, Amusa, G, Ancuceanu, R, Anderlini, D, Anderson, D, Andrade, P, Andrei, C, Andrei, T, Angus, C, Anil, A, Anil, S, Anoushiravani, A, Ansari, H, Ansariadi, A, Ansari-Moghaddam, A, Antony, C, Antriyandarti, E, Anvari, D, Anvari, S, Anwar, S, Anwer, R, Anyasodor, A, Aqeel, M, Arab, J, Arabloo, J, Arafat, M, Aravkin, A, Areda, D, Aremu, A, Aremu, O, Ariffin, H, Arkew, M, Armocida, B, Arndt, M, Ärnlöv, J, Arooj, M, Artamonov, A, Arulappan, J, Aruleba, R, Arumugam, A, Asaad, M, Asadi-Lari, M, Asgedom, A, Asghariahmadabad, M, Asghari-Jafarabadi, M, Ashraf, M, Aslani, A, Astell-Burt, T, Athar, M, Athari, S, Atinafu, B, Atlaw, H, Atorkey, P, Atout, M, Atreya, A, Aujayeb, A, Ausloos, M, Avan, A, Awedew, A, Aweke, A, Ayala Quintanilla, B, Ayatollahi, H, Ayuso-Mateos, J, Ayyoubzadeh, S, Azadnajafabad, S, Azevedo, R, Azzam, A, B, D, Babu, A, Badar, M, Badiye, A, Baghdadi, S, Bagheri, N, Bagherieh, S, Bah, S, Bahadorikhalili, S, Bahmanziari, N, Bai, R, Baig, A, Baker, J, Bako, A, Bakshi, R, Balakrishnan, S, Balasubramanian, M, Baltatu, O, Bam, K, Banach, M, Bandyopadhyay, S, Banik, P, Bansal, H, Bansal, K, Barbic, F, Barchitta, M, Bardhan, M, Bardideh, E, Barker-Collo, S, Bärnighausen, T, Barone-Adesi, F, Barqawi, H, Barrero, L, Barrow, A, Barteit, S, Barua, L, Basharat, Z, Bashiri, A, Basiru, A, Baskaran, P, Basnyat, B, Bassat, Q, Basso, J, Basting, A, Basu, S, Batra, K, Baune, B, Bayati, M, Bayileyegn, N, Beaney, T, Bedi, N, Beghi, M, Behboudi, E, Behera, P, Behnoush, A, Behzadifar, M, Beiranvand, M, Bejarano Ramirez, D, Béjot, Y, Belay, S, Belete, C, Bell, M, Bello, M, Bello, O, Belo, L, Beloukas, A, Bender, R, Bensenor, I, Beran, A, Berezvai, Z, Berhie, A, Berice, B, Bernstein, R, Bertolacci, G, Bettencourt, P, Beyene, K, Bhagat, D, Bhagavathula, A, Bhala, N, Bhalla, A, Bhandari, D, Bhangdia, K, Bhardwaj, N, Bhardwaj, P, Bhargava, A, Bhaskar, S, Bhat, V, Bhatti, G, Bhatti, J, Bhatti, M, Bhatti, R, Bhutta, Z, Bikbov, B, Bishai, J, Bisignano, C, Bisulli, F, Biswas, A, Biswas, B, Bitaraf, S, Bitew, B, Bitra, V, Bjørge, T, Boachie, M, Boampong, M, Bobirca, A, Bodolica, V, Bodunrin, A, Bogale, E, Bogale, K, Bohlouli, S, Bolarinwa, O, Boloor, A, Bonakdar Hashemi, M, Bonny, A, Bora, K, Bora Basara, B, Borhany, H, Borzutzky, A, Bouaoud, S, Boustany, A, Boxe, C, Boyko, E, Brady, O, Braithwaite, D, Brant, L, Brauer, M, Brazinova, A, Brazo-Sayavera, J, Breitborde, N, Breitner, S, Brenner, H, Briko, A, Briko, N, Britton, G, Brown, J, Brugha, T, Bulamu, N, Bulto, L, Buonsenso, D, Burns, R, Busse, R, Bustanji, Y, Butt, N, Butt, Z, Caetano dos Santos, F, Calina, D, Cámera, L, Campos, L, Campos-Nonato, I, Cao, C, Cao, Y, Capodici, A, Cárdenas, R, Carr, S, Carreras, G, Carrero, J, Carugno, A, Carvalheiro, C, Carvalho, F, Carvalho, M, Castaldelli-Maia, J, Castañeda-Orjuela, C, Castelpietra, G, Catalá-López, F, Catapano, A, Cattaruzza, M, Cederroth, C, Cegolon, L, Cembranel, F, Cenderadewi, M, Cercy, K, Cerin, E, Cevik, M, Chadwick, J, Chahine, Y, Chakraborty, C, Chakraborty, P, Chan, J, Chan, R, Chandika, R, Chandrasekar, E, Chang, C, Chang, J, Chanie, G, Charalampous, P, Chattu, V, Chaturvedi, P, Chatzimavridou-Grigoriadou, V, Chaurasia, A, Chen, A, Chen, C, Chen, H, Chen, M, Chen, S, Cheng, C, Cheng, E, Cherbuin, N, Cheru, W, Chien, J, Chimed-Ochir, O, Chimoriya, R, Ching, P, Chirinos-Caceres, J, Chitheer, A, Cho, W, Chong, B, Chopra, H, Choudhari, S, Chowdhury, R, Christopher, D, Chukwu, I, Chung, E, Chung, S, Chutiyami, M, Cindi, Z, Cioffi, I, Claassens, M, Claro, R, Coberly, K, Cogen, R, Columbus, A, Comfort, H, Conde, J, Cortese, S, Cortesi, P, Costa, V, Costanzo, S, Cousin, E, Couto, R, Cowden, R, Cramer, K, Criqui, M, Cruz-Martins, N, Cuadra-Hernández, S, Culbreth, G, Cullen, P, Cunningham, M, Curado, M, Dadana, S, Dadras, O, Dai, S, Dai, X, Dai, Z, Dalli, L, Damiani, G, Darega Gela, J, Das, J, Das, S, Dascalu, A, Dash, N, Dashti, M, Dastiridou, A, Davey, G, Dávila-Cervantes, C, Davis Weaver, N, Davletov, K, De Leo, D, de Luca, K, Debele, A, Debopadhaya, S, Degenhardt, L, Dehghan, A, Deitesfeld, L, Del Bo', C, Delgado-Enciso, I, Demessa, B, Demetriades, A, Deng, K, Deng, X, Denova-Gutiérrez, E, Deravi, N, Dereje, N, Dervenis, N, Dervišević, E, Des Jarlais, D, Desai, H, Desai, R, Devanbu, V, Dewan, S, Dhali, A, Dhama, K, Dhimal, M, Dhingra, S, Dhulipala, V, Dias da Silva, D, Diaz, D, Diaz, M, Dima, A, Ding, D, Ding, H, Dinis-Oliveira, R, Dirac, M, Djalalinia, S, Do, T, do Prado, C, Doaei, S, Dodangeh, M, Dohare, S, Dokova, K, Dolecek, C, Dominguez, R, Dong, W, Dongarwar, D, D'Oria, M, Dorostkar, F, Dorsey, E, dos Santos, W, Doshi, R, Doshmangir, L, Dowou, R, Driscoll, T, Dsouza, H, Dsouza, V, Du, M, Dube, J, Duncan, B, Duraes, A, Duraisamy, S, Durojaiye, O, Dwyer-Lindgren, L, Dzianach, P, Dziedzic, A, E'Mar, A, Eboreime, E, Ebrahimi, A, Echieh, C, Edinur, H, Edvardsson, D, Edvardsson, K, Efendi, D, Efendi, F, Effendi, D, Eikemo, T, Eini, E, Ekholuenetale, M, Ekundayo, T, El Sayed, I, Elbarazi, I, Elema, T, Elemam, N, Elgar, F, Elgendy, I, Elgohary, G, Elhabashy, H, Elhadi, M, El-Huneidi, W, Elilo, L, Elmeligy, O, Elmonem, M, Elshaer, M, Elsohaby, I, Emeto, T, Engelbert Bain, L, Erkhembayar, R, Esezobor, C, Eshrati, B, Eskandarieh, S, Espinosa-Montero, J, Esubalew, H, Etaee, F, Fabin, N, Fadaka, A, Fagbamigbe, A, Fahim, A, Fahimi, S, Fakhri-Demeshghieh, A, Falzone, L, Fareed, M, Farinha, C, Faris, M, Faris, P, Faro, A, Fasanmi, A, Fatehizadeh, A, Fattahi, H, Fauk, N, Fazeli, P, Feigin, V, Feizkhah, A, Fekadu, G, Feng, X, Fereshtehnejad, S, Feroze, A, Ferrante, D, Ferrari, A, Ferreira, N, Fetensa, G, Feyisa, B, Filip, I, Fischer, F, Flavel, J, Flood, D, Florin, B, Foigt, N, Folayan, M, Fomenkov, A, Foroutan, B, Foroutan, M, Forthun, I, Fortuna, D, Foschi, M, Fowobaje, K, Francis, K, Franklin, R, Freitas, A, Friedman, J, Friedman, S, Fukumoto, T, Fuller, J, Fux, B, Gaal, P, Gadanya, M, Gaidhane, A, Gaihre, S, Gakidou, E, Galali, Y, Galles, N, Gallus, S, Ganbat, M, Gandhi, A, Ganesan, B, Ganiyani, M, Garcia-Gordillo, M, Gardner, W, Garg, J, Garg, N, Gautam, R, Gbadamosi, S, Gebi, T, Gebregergis, M, Gebrehiwot, M, Gebremeskel, T, Georgescu, S, Getachew, T, Gething, P, Getie, M, Ghadiri, K, Ghahramani, S, Ghailan, K, Ghasemi, M, Ghasempour Dabaghi, G, Ghasemzadeh, A, Ghashghaee, A, Ghassemi, F, Ghazy, R, Ghimire, A, Ghoba, S, Gholamalizadeh, M, Gholamian, A, Gholamrezanezhad, A, Gholizadeh, N, Ghorbani, M, Ghorbani Vajargah, P, Ghoshal, A, Gill, P, Gill, T, Gillum, R, Ginindza, T, Girmay, A, Glasbey, J, Gnedovskaya, E, Göbölös, L, Godinho, M, Goel, A, Golchin, A, Goldust, M, Golechha, M, Goleij, P, Gomes, N, Gona, P, Gopalani, S, Gorini, G, Goudarzi, H, Goulart, A, Goulart, B, Goyal, A, Grada, A, Graham, S, Grivna, M, Grosso, G, Guan, S, Guarducci, G, Gubari, M, Gudeta, M, Guha, A, Guicciardi, S, Guimarães, R, Gulati, S, Gunawardane, D, Gunturu, S, Guo, C, Gupta, A, Gupta, B, Gupta, M, Gupta, R, Gupta, S, Gupta, V, Gurmessa, L, Gutiérrez, R, Habibzadeh, F, Habibzadeh, P, Haddadi, R, Hadei, M, Hadi, N, Haep, N, Hafezi-Nejad, N, Hailu, A, Haj-Mirzaian, A, Halboub, E, Hall, B, Haller, S, Halwani, R, Hamadeh, R, Hameed, S, Hamidi, S, Hamilton, E, Han, C, Han, Q, Hanif, A, Hanifi, N, Hankey, G, Hanna, F, Hannan, M, Haque, M, Harapan, H, Hargono, A, Haro, J, Hasaballah, A, Hasan, I, Hasan, M, Hasani, H, Hasanian, M, Hashi, A, Hasnain, M, Hassan, I, Hassanipour, S, Hassankhani, H, Haubold, J, Havmoeller, R, Hay, S, He, J, Hebert, J, Hegazi, O, Heidari, G, Heidari, M, Heidari-Foroozan, M, Helfer, B, Hendrie, D, Herrera-Serna, B, Herteliu, C, Hesami, H, Hezam, K, Hill, C, Hiraike, Y, Holla, R, Horita, N, Hossain, M, Hossain, S, Hosseini, M, Hosseinzadeh, H, Hosseinzadeh, M, Hosseinzadeh Adli, A, Hostiuc, M, Hostiuc, S, Hsairi, M, Hsieh, V, Hsu, R, Hu, C, Huang, J, Hultström, M, Humayun, A, Hundie, T, Hussain, J, Hussain, M, Hussein, N, Hussien, F, Huynh, H, Hwang, B, Ibitoye, S, Ibrahim, K, Iftikhar, P, Ijo, D, Ikiroma, A, Ikuta, K, Ikwegbue, P, Ilesanmi, O, Ilic, I, Ilic, M, Imam, M, Immurana, M, Inamdar, S, Indriasih, E, Iqhrammullah, M, Iradukunda, A, Iregbu, K, Islam, M, Islam, S, Islami, F, Ismail, F, Ismail, N, Iso, H, Isola, G, Iwagami, M, Iwu, C, Iyamu, I, Iyer, M, J, L, Jaafari, J, Jacob, L, Jacobsen, K, Jadidi-Niaragh, F, Jafarinia, M, Jafarzadeh, A, Jaggi, K, Jahankhani, K, Jahanmehr, N, Jahrami, H, Jain, N, Jairoun, A, Jaiswal, A, Jamshidi, E, Janko, M, Jatau, A, Javadov, S, Javaheri, T, Jayapal, S, Jayaram, S, Jebai, R, Jee, S, Jeganathan, J, Jha, A, Jha, R, Jiang, H, Jin, Y, Johnson, O, Jokar, M, Jonas, J, Joo, T, Joseph, A, Joseph, N, Joshua, C, Joshy, G, Jozwiak, J, Jürisson, M, K, V, Kaambwa, B, Kabir, A, Kabir, Z, Kadashetti, V, Kadir, D, Kalani, R, Kalankesh, L, Kaliyadan, F, Kalra, S, Kamal, V, Kamarajah, S, Kamath, R, Kamiab, Z, Kamyari, N, Kanagasabai, T, Kanchan, T, Kandel, H, Kanmanthareddy, A, Kanmiki, E, Kanmodi, K, Kannan S, S, Kansal, S, Kantar, R, Kapoor, N, Karajizadeh, M, Karanth, S, Karasneh, R, Karaye, I, Karch, A, Karim, A, Karimi, S, Karimi Behnagh, A, Kashoo, F, Kasnazani, Q, Kasraei, H, Kassebaum, N, Kassel, M, Kauppila, J, Kaur, N, Kawakami, N, Kayode, G, Kazemi, F, Kazemian, S, Kazmi, T, Kebebew, G, Kebede, A, Kebede, F, Keflie, T, Keiyoro, P, Keller, C, Kelly, J, Kempen, J, Kerr, J, Kesse-Guyot, E, Khajuria, H, Khalaji, A, Khalid, N, Khalil, A, Khalilian, A, Khamesipour, F, Khan, A, Khan, G, Khan, I, Khan, M, Khan, Z, Khan suheb, M, Khanmohammadi, S, Khatab, K, Khatami, F, Khatatbeh, H, Khatatbeh, M, Khavandegar, A, Khayat Kashani, H, Khidri, F, Khodadoust, E, Khorgamphar, M, Khormali, M, Khorrami, Z, Khosravi, A, Khosravi, M, Kifle, Z, Kim, G, Kim, J, Kim, K, Kim, M, Kim, Y, Kimokoti, R, Kinzel, K, Kisa, A, Kisa, S, Klu, D, Knudsen, A, Kocarnik, J, Kochhar, S, Kocsis, T, Koh, D, Kolahi, A, Kolves, K, Kompani, F, Koren, G, Kosen, S, Kostev, K, Koul, P, Koulmane Laxminarayana, S, Krishan, K, Krishna, H, Krishna, V, Krishnamoorthy, V, Krishnamoorthy, Y, Krohn, K, Kuate Defo, B, Kucuk Bicer, B, Kuddus, M, Kuitunen, I, Kulimbet, M, Kulkarni, V, Kumar, A, Kumar, H, Kumar, M, Kumar, R, Kumari, M, Kumie, F, Kundu, S, Kurmi, O, Kusnali, A, Kusuma, D, Kwarteng, A, Kyriopoulos, I, Kyu, H, La Vecchia, C, Lacey, B, Ladan, M, Laflamme, L, Lagat, A, Lager, A, Lahmar, A, Lai, D, Lal, D, Lalloo, R, Lallukka, T, Lam, H, Lám, J, Landrum, K, Lanfranchi, F, Lang, J, Langguth, B, Lansingh, V, Laplante-Lévesque, A, Larijani, B, Larsson, A, Lasrado, S, Lassi, Z, Latief, K, Latifinaibin, K, Lauriola, P, Le, N, Le, T, Ledda, C, Ledesma, J, Lee, M, Lee, P, Lee, S, Lee, W, Lee, Y, Legrand, K, Leigh, J, Leong, E, Lerango, T, Li, M, Li, W, Li, X, Li, Y, Li, Z, Ligade, V, Likaka, A, Lim, L, Lim, S, Lindstrom, M, Linehan, C, Liu, C, Liu, G, Liu, J, Liu, R, Liu, S, Liu, X, Llanaj, E, Loftus, M, López-Bueno, R, Lopukhov, P, Loreche, A, Lorkowski, S, Lotufo, P, Lozano, R, Lubinda, J, Lucchetti, G, Lugo, A, Lunevicius, R, Ma, Z, Maass, K, Machairas, N, Machoy, M, Madadizadeh, F, Madsen, C, Madureira-Carvalho, Á, Maghazachi, A, Maharaj, S, Mahjoub, S, Mahmoud, M, Mahmoudi, A, Mahmoudi, E, Mahmoudi, R, Majeed, A, Makhdoom, I, Malakan Rad, E, Maled, V, Malekzadeh, R, Malhotra, A, Malhotra, K, Malik, A, Malik, I, Malta, D, Mamun, A, Mansouri, P, Mansournia, M, Mantovani, L, Maqsood, S, Marasini, B, Marateb, H, Maravilla, J, Marconi, A, Mardi, P, Marino, M, Marjani, A, Martinez, G, Martinez-Guerra, B, Martinez-Piedra, R, Martini, D, Martini, S, Martins-Melo, F, Martorell, M, Marx, W, Maryam, S, Marzo, R, Masaka, A, Masrie, A, Mathieson, S, Mathioudakis, A, Mathur, M, Mattumpuram, J, Matzopoulos, R, Maude, R, Maugeri, A, Maulik, P, Mayeli, M, Mazaheri, M, Mazidi, M, Mcgrath, J, Mckee, M, Mckowen, A, Mclaughlin, S, Mcphail, S, Mechili, E, Medina, J, Mediratta, R, Meena, J, Mehra, R, Mehrabani-Zeinabad, K, Mehrabi Nasab, E, Mekene Meto, T, Meles, G, Mendez-Lopez, M, Mendoza, W, Menezes, R, Mengist, B, Mentis, A, Meo, 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- Published
- 2024
3. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
- Author
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Pourtaheri, Naeimeh, Prabhu, Disha, Prada, Sergio I, Pradhan, Jalandhar, Pradhan, Pranil Man Singh, Prasad, Manya, Prates, Elton Junio Sady, Purnobasuki, Hery, Purohit, Bharathi M, Puvvula, Jagadeesh, Qasim, Nameer Hashim, Qattea, Ibrahim, Qazi, Asma Saleem, Qian, Gangzhen, Qiu, Suli, Rabiee Rad, Mehrdad, Radfar, Amir, Radhakrishnan, Raghu Anekal, Radhakrishnan, Venkatraman, Raeisi Shahraki, Hadi, Rafferty, Quinn, Rafiei, Alireza, Raggi, Alberto, Raghav, Pankaja Raghav, Raheem, Nasiru, Rahim, Fakher, Rahim, Md Jillur, Rahimifard, Mahban, Rahimi-Movaghar, Vafa, Rahman, Md Obaidur, Rahman, Muhammad Aziz, Rahmani, Amir Masoud, Rahmani, Bita, Rahmanian, Mohammad, Rahmanian, Nazanin, Rahmanian, Vahid, Rahmati, Masoud, Rahmawaty, Setyaningrum, Raimondo, Diego, Rajaa, Sathish, Rajendran, Vinoth, Rajput, Prashant, Ramadan, Mahmoud Mohammed, Ramasamy, Shakthi Kumaran, Ramasubramani, Premkumar, Ramazanu, Sheena, Ramteke, Pramod W, Rana, Juwel, Rana, Kritika, Ranabhat, Chhabi Lal, Rane, Amey, Rani, Usha, Ranta, Annemarei, Rao, Chythra R, Rao, Mithun, Rao, Puja C, Rao, Sowmya J, Rasella, Davide, Rashedi, Sina, Rashedi, Vahid, Rashidi, Mahsa, Rashidi, Mohammad-Mahdi, Rasouli-Saravani, Ashkan, Ratan, Zubair Ahmed, Rathnaiah Babu, Giridhara, Rauniyar, Santosh Kumar, Rautalin, Ilari, Rawaf, David Laith, Rawaf, Salman, Rawassizadeh, Reza, Razo, Christian, Reda, Zinabu Ferede Ferede, Reddy, Murali Mohan Rama Krishna, Redwan, Elrashdy Moustafa Mohamed, Reifels, Lennart, Reitsma, Marissa B, Remuzzi, Giuseppe, Reshmi, Bhageerathy, Resnikoff, Serge, Restaino, Stefano, Reyes, Luis Felipe, Rezaei, Maryam, Rezaei, Nazila, Rezaei, Negar, Rezaeian, Mohsen, Rhee, Taeho Gregory, Riaz, Mavra A, Ribeiro, Antonio Luiz P, Rickard, Jennifer, Robinson-Oden, Hannah Elizabeth, Rodrigues, Célia Fortuna, Rodrigues, Mónica, Rodriguez, Jefferson Antonio Buendia, Roever, Leonardo, Romadlon, Debby Syahru, Ronfani, Luca, Rosauer, Jennifer Jacqueline, Roshandel, Gholamreza, Rostamian, Morteza, Rotimi, Kunle, Rout, Himanshu Sekhar, Roy, Bedanta, Roy, Nitai, Rubagotti, Enrico, Ruela, Guilherme de Andrade, Rumisha, Susan Fred, Runghien, Tilleye, Russo, Michele, Ruzzante, Sacha Walde, S N, Chandan, Saad, Aly M A, Saber, Korosh, Saber-Ayad, Maha Mohamed, Sabour, Siamak, Sacco, Simona, Sachdev, Perminder S, Sachdeva, Rajesh, Saddik, Basema, Saddler, Adam, Sadee, Bashdar Abuzed, Sadeghi, Ehsan, Sadeghi, Masoumeh, Sadeghi Majd, Elham, Saeb, Mohammad Reza, Saeed, Umar, Safari, Mehdi, Safi, Sare, Safi, Sher Zaman, Sagar, Rajesh, Sagoe, Dominic, Saheb Sharif-Askari, Fatemeh, Saheb Sharif-Askari, Narjes, Sahebkar, Amirhossein, Sahoo, Soumya Swaroop, Sahu, Monalisha, Saif, Zahra, Sajid, Mirza Rizwan, Sakshaug, Joseph W, Salam, Nasir, Salamati, Payman, Salami, Afeez Abolarinwa, Salaroli, Luciane B, Salehi, Leili, Salehi, Sana, Salem, Marwa Rashad, Salem, Mohammed Z Y, Salihu, Dauda, Salimi, Sohrab, Salum, Giovanni A, Samadi Kafil, Hossein, Samadzadeh, Sara, Samodra, Yoseph Leonardo, Samuel, Vijaya Paul, Samy, Abdallah M, Sanabria, Juan, Sanjeev, Rama Krishna, Sanna, Francesca, Santomauro, Damian Francesco, Santric-Milicevic, Milena M, Sarasmita, Made Ary, Saraswathy, Sivan Yegnanarayana Iyer, Saravanan, Aswini, Saravi, Babak, Sarikhani, Yaser, Sarmiento-Suárez, Rodrigo, Sarode, Gargi Sachin, Sarode, Sachin C, Sartorius, Benn, Sarveazad, Arash, Sathian, Brijesh, Sattin, Davide, Sawhney, Monika, Saya, Ganesh Kumar, Sayeed, Abu, Sayeed, Md Abu, Sayyah, Mehdi, Schinckus, Christophe, Schmidt, Maria Inês, Schuermans, Art, Schumacher, Austin E, Schutte, Aletta Elisabeth, Schwarzinger, Michaël, Schwebel, David C, Schwendicke, Falk, Selvaraj, Siddharthan, Semreen, Mohammad H, Senthilkumaran, Subramanian, Serban, Dragos, Serre, Marc L, Sethi, Yashendra, Shafie, Mahan, Shah, Humaira, Shah, Nilay S, Shah, Pritik A, Shah, Syed Mahboob, Shahbandi, Ataollah, Shaheen, Amira A, Shahid, Samiah, Shahid, Wajeehah, Shahsavari, Hamid R, Shahwan, Moyad Jamal, Shaikh, Masood Ali, Shaikh, Summaiya Zareen, Shalash, Ali S, Sham, Sunder, Shamim, Muhammad Aaqib, Shams-Beyranvand, Mehran, Shamshirgaran, Mohammad Ali, Shamsi, Mohammad Anas, Shanawaz, Mohd, Shankar, Abhishek, Sharfaei, Sadaf, Sharifan, Amin, Sharifi-Rad, Javad, Sharma, Manoj, Sharma, Ujjawal, Sharma, Vishal, Shastry, Rajesh P, Shavandi, Amin, Shehabeldine, Amr Mohamed Elsayed, Shehzadi, Somia, Sheikh, Aziz, Shen, Jiabin, Shetty, Adithi, Shetty, B Suresh Kumar, Shetty, Pavanchand H, Shiani, Amir, Shiferaw, Desalegn, Shigematsu, Mika, Shin, Min-Jeong, Shiri, Rahman, Shittu, Aminu, Shiue, Ivy, Shivakumar, K M, Shivarov, Velizar, Shool, Sina, Shorofi, Seyed Afshin, Shrestha, Rajan, Shrestha, Sunil, Shuja, Kanwar Hamza, Shuval, Kerem, Si, Yafei, Siddig, Emmanuel Edwar, Silva, Diego Augusto Santos, Silva, Luís Manuel Lopes Rodrigues, Silva, Soraia, Silva, Thales Philipe R, Simpson, Colin R, Singh, Abhinav, Singh, Balbir Bagicha, Singh, Baljinder, Singh, Garima, Singh, Harmanjit, Singh, Jasvinder A, Singh, Mahendra, Singh, Narinder Pal, Singh, Paramdeep, Singh, Surjit, Sinto, Robert, Sivakumar, Shravan, Siwal, Samarjeet Singh, Skhvitaridze, Natia, Skou, Søren T, Sleet, David A, Sobia, Farrukh, Soboka, Matiwos, Socea, Bogdan, Solaimanian, Shahabaddin, Solanki, Ranjan, Solanki, Shipra, Soliman, Sameh S M, Somayaji, Ranjani, Song, Yi, Sorensen, Reed J D, Soriano, Joan B, Soyiri, Ireneous N, Spartalis, Michael, Spearman, Sandra, Spencer, Cory N, Sreeramareddy, Chandrashekhar T, Stachteas, Panagiotis, Stafford, Lauryn K, Stanaway, Jeffrey D, Stanikzai, Muhammad Haroon, Stein, Caroline, Stein, Dan J, Steinbeis, Fridolin, Steiner, Caitlyn, Steinke, Sabine, Steiropoulos, Paschalis, Stockfelt, Leo, Stokes, Mark A, Straif, Kurt, Stranges, Saverio, Subedi, Narayan, Subramaniyan, Vetriselvan, Suleman, Muhammad, Suliankatchi Abdulkader, Rizwan, Sundström, Johan, Sunkersing, David, Sunnerhagen, Katharina S, Suresh, Vinay, Swain, Chandan Kumar, Szarpak, Lukasz, Szeto, Mindy D, Tabaee Damavandi, Payam, Tabarés-Seisdedos, Rafael, Tabatabaei, Seyyed Mohammad, Tabatabaei Malazy, Ozra, Tabatabaeizadeh, Seyed-Amir, Tabatabai, Shima, Tabche, Celine, Tabish, Mohammad, Tadakamadla, Santosh Kumar, Taheri Abkenar, Yasaman, Taheri Soodejani, Moslem, Taherkhani, Amir, Taiba, Jabeen, Takahashi, Ken, Talaat, Iman M, Tamuzi, Jacques Lukenze, Tan, Ker-Kan, Tang, Haosu, Tat, Nathan Y, Taveira, Nuno, Tefera, Yibekal Manaye, Tehrani-Banihashemi, Arash, Temesgen, Worku Animaw, Temsah, Mohamad-Hani, Teramoto, Masayuki, Terefa, Dufera Rikitu, Teye-Kwadjo, Enoch, Thakur, Ramna, Thangaraju, Pugazhenthan, Thankappan, Kavumpurathu Raman, Thapar, Rekha, Thayakaran, Rasiah, Thirunavukkarasu, Sathish, Thomas, Nihal, Thomas, Nikhil Kenny, Tian, Jing, Tichopad, Ales, Ticoalu, Jansje Henny Vera, Tiruye, Tenaw Yimer, Tobe-Gai, Ruoyan, Tolani, Musliu Adetola, Tolossa, Tadesse, Tonelli, Marcello, Topor-Madry, Roman, Topouzis, Fotis, Touvier, Mathilde, Tovani-Palone, Marcos Roberto, Trabelsi, Khaled, Tran, Jasmine T, Tran, Mai Thi Ngoc, Tran, Nghia Minh, Trico, Domenico, Trihandini, Indang, Troeger, Christopher E, Tromans, Samuel Joseph, Truyen, Thien Tan Tri Tai, Tsatsakis, Aristidis, Tsermpini, Evangelia Eirini, Tumurkhuu, Munkhtuya, Udoakang, Aniefiok John, Udoh, Arit, Ullah, Atta, Ullah, Saeed, Ullah, Sana, Umair, Muhammad, Umakanthan, Srikanth, Unim, Brigid, Unnikrishnan, Bhaskaran, Upadhyay, Era, Urso, Daniele, Usman, Jibrin Sammani, Vaithinathan, Asokan Govindaraj, Vakili, Omid, Valenti, Mario, Valizadeh, Rohollah, Van den Eynde, Jef, van Donkelaar, Aaron, Varga, Orsolya, Vart, Priya, Varthya, Shoban Babu, Vasankari, Tommi Juhani, Vasic, Milena, Vaziri, Siavash, Venketasubramanian, Narayanaswamy, Verghese, Nicholas Alexander, Verma, Madhur, Veroux, Massimiliano, Verras, Georgios-Ioannis, Vervoort, Dominique, Villafañe, Jorge Hugo, Villalobos-Daniel, Victor E, Villani, Leonardo, Villanueva, Gabriela Ines, Vinayak, Manish, Violante, Francesco S, Vlassov, Vasily, Vo, Bay, Vollset, Stein Emil, Volovat, Simona Ruxandra, Vos, Theo, Vujcic, Isidora S, Waheed, Yasir, Wang, Cong, Wang, Fang, Wang, Shu, Wang, Yanzhong, Wang, Yuan-Pang, Wanjau, Mary Njeri, Waqas, Muhammad, Ward, Paul, Waris, Abdul, Wassie, Emebet Gashaw, Weerakoon, Kosala Gayan, Weintraub, Robert G, Weiss, Daniel J, Weiss, Eli J, Weldetinsaa, Haftom Legese Legese, Wells, Katherine M, Wen, Yi Feng, Wiangkham, Taweewat, Wickramasinghe, Nuwan Darshana, Wilkerson, Caroline, Willeit, Peter, Wilson, Shadrach, Wong, Yen Jun, Wongsin, Utoomporn, Wozniak, Sarah, Wu, Chenkai, Wu, Dongze, Wu, Felicia, Wu, Zenghong, Xia, Juan, Xiao, Hong, Xu, Suowen, Xu, Xiaoyue, Xu, Yvonne Yiru, Yadav, Mukesh Kumar, Yaghoubi, Sajad, Yamagishi, Kazumasa, Yang, Lin, Yano, Yuichiro, Yaribeygi, Habib, Yasufuku, Yuichi, Ye, Pengpeng, Yesodharan, Renjulal, Yesuf, Subah Abderehim, Yezli, Saber, Yi, Siyan, Yiğit, Arzu, Yigzaw, Zeamanuel Anteneh, Yin, Dehui, Yip, Paul, Yismaw, Malede Berihun, Yon, Dong Keon, Yonemoto, Naohiro, You, Yuyi, Younis, Mustafa Z, Yousefi, Zabihollah, Yu, Chuanhua, Yu, Yong, Zadey, Siddhesh, Zadnik, Vesna, Zakham, Fathiah, Zaki, Nazar, Zakzuk, Josefina, Zamagni, Giulia, Zaman, Sojib Bin, Zandieh, Ghazal G Z, Zanghì, Aurora, Zar, Heather J, Zare, Iman, Zarimeidani, Fatemeh, Zastrozhin, Mikhail Sergeevich, Zeng, Youjie, Zhai, Chunxia, Zhang, Anthony Lin, Zhang, Haijun, Zhang, Liqun, Zhang, Meixin, Zhang, Yunquan, Zhang, Zhenyu, Zhang, Zhi-Jiang, Zhao, Hanqing, Zhao, Jeff T, Zhao, Xiu-Ju George, Zhao, Yang, Zhao, Yong, Zhong, Chenwen, Zhou, Jingjing, Zhou, Juexiao, Zhou, Shangcheng, Zhu, Bin, Zhu, Lei, Zhu, Zhaohua, Ziaeian, Boback, Ziafati, Makan, Zielińska, Magdalena, Zimsen, Stephanie R M, Zoghi, Ghazal, Zoller, Thomas, Zumla, Alimuddin, Zyoud, Sa'ed H, Zyoud, Samer H, Murray, Christopher J L, and Gakidou, Emmanuela
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- 2024
4. Conventional paraffin embedding technique and double-embedding technique for minute oral biopsies and delicate pulp tissue — a comparative study
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Sundararajan, A., primary, Muthusamy, R., additional, Prasad, H., additional, Sri Chinthu, K.K., additional, and Selvakumar, R., additional
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- 2024
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5. May nanoparticles offer chances to avoid the development of insecticide resistance in mosquitoes?
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Yashkamal, K., primary, Vivekanandhan, P., additional, Muthusamy, R., additional, Vengateswari, G., additional, and Shivakumar, M.S., additional
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- 2021
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6. Contributors
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Aderibigbe, B.A., primary, Akolade, Jubril O., additional, Alex Christon, R., additional, Alven, S., additional, Amaral, Ricardo Guimarães, additional, Andrade, Luciana Nalone, additional, Bahia, Maria Terezinha, additional, Balogun, Abideen O., additional, Balogun, Mohammed O., additional, Barbosa, Leandro R.S., additional, Barbosa, Raquel de Melo, additional, Basso, Caroline R., additional, Berzosa, Melibea, additional, Branquinha, Marta Helena, additional, Câmara, Gabriel Bezerra Motta, additional, Cardoso, Juliana Cordeiro, additional, Carvalhal, Kevin Silva, additional, Carlos Tavares Carvalho, José, additional, de Carvalho Oliveira, Simone Santiago, additional, Casadei, Bruna Renata, additional, Castro, Gustavo R., additional, Crulhas, Bruno P., additional, Cruz, Jorddy Neves, additional, do Socorro Pires e Cruz, Maria, additional, da Cunha Gonsalves, Joyce Kelly Marinheiro, additional, da Silva Júnior, Eugênio Fonseca, additional, da Silva Souza Filho, Antonio Pedro, additional, Deepika, Subramanyam, additional, Feitosa, Judith Pessoa A., additional, Pinho Fernandes, Caio, additional, Finkler, Christine Lamenha Luna, additional, Galvão, Juliana Gouveia, additional, Gamazo, Carlos, additional, García-Villén, Fátima, additional, Gnanadesigan, Murugesan, additional, de Gomes, Marcelo Gomes, additional, González-Gaitano, Gustavo, additional, Gopakumar Nageswari, Gopika, additional, Haas, Sandra Elisa, additional, Harishkumar, Rajendran, additional, Hazarika, Zaved, additional, Iborra, Cesar Viseras, additional, Irache, Juan M., additional, Janarthanan, V., additional, Jha, Anupam Nath, additional, Joardar, Nikhilesh, additional, Kiruthika, Rangaraj, additional, Lotierzo, Mayra C.G., additional, Maciel, Tamara Ramos, additional, Malheiros, Barbara, additional, Mazzeti, Ana Lia, additional, Meirelles, Lyghia Maria Araújo, additional, Melo, Claudia Moura, additional, Mohana Roopan, Selvaraj, additional, Mondal, Anupam, additional, Mondal, Naba Kumar, additional, Mosqueira, Vanessa Carla Furtado, additional, Dias de Moura, Luana, additional, Mukherjee, Niladri, additional, Muthusamy, R., additional, Fabrício Marçal do Nascimento, Leopoldo, additional, Nguewa, Paul, additional, Novais, Gabrielle Barrozo, additional, Eliza Maciel de Faria Mota Oliveira, Anna, additional, Oliveira, Douglas Santos, additional, Oliveira, Marcos Enê Chaves, additional, de Oliveira, Mozaniel Santana, additional, Pastor, Yadira, additional, Paula, Haroldo Cesar B., additional, de Paula, Regina Célia Monteiro, additional, Pedrosa, Valber A., additional, Peña-Guerrero, José, additional, Pereira, Daniel Santiago, additional, Puig-Rigall, Joan, additional, Raffin, Fernanda Nervo, additional, Rajkhowa, Sanchaita, additional, Richter, Ana Rosa, additional, Sangenito, Leandro Stefano, additional, Santana, Robertta Jussara Rodrigues, additional, Luis Souza dos Santos, André, additional, Santos, André Luis Souza dos, additional, Selvaraj, Chinnadurai Immanuel, additional, Severino, Patrícia, additional, Shivakumar, M.S., additional, Sinha Babu, Santi P., additional, Souto, Eliana Maria Barbosa, additional, C Vallur, Aarthy, additional, Vengateswari, G., additional, Vivekanandhan, P., additional, Yashkamal, K., additional, and Ortiz Zamora, Lisset, additional
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- 2021
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7. An Avoidance Control Strategy for Joint-Position Limits of Dual-Arm Robots
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Foresi, G., Freddi, A., Kyrki, V., Monteriù, A., Muthusamy, R., Ortenzi, D., and Pagnotta, D. Proietti
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- 2017
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8. Racemic Guaifenesin Preparation by in vivo Williamson ether synthesis and FTIR, NMR, HPLC and GCMS spectral analysis
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SURESH K, Selvaraj, V., Mathiyazhagan, N., and Muthusamy, R.
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Renewable Energy, Sustainability and the Environment ,General Chemical Engineering ,General Earth and Planetary Sciences ,General Chemistry ,General Agricultural and Biological Sciences ,Biochemistry ,General Environmental Science - Abstract
The preparation of racemic guaifenesin (3-(2- methoxyphenoxy)-1,2-propanediol by a Williamson ether synthesis reaction was well-suited towards the reaction mechanisms, spectroscopic analysis and pharmaceutical synthesis of enantioselective compound. Analysis of the reaction products includes NMR, HPLC, GC techniques that involve comparison of the reaction products to known standards. The most characteristic peaks in an IR spectrum are those associated with O-H bonds (strong, broad peaks, 2968.80 cm--1) and the carbonyl group (C=O, strong peaks 1379.10 cm--1). Identification of synthesized product structure chemical shift occurred at 3.2 ppm indicating the presence of methyl compound in structure of guaifenesin and the molecular mass synthesized product was found to be 198g/mol for guaifenesin compound with the CAS No.of 93-14-1.
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- 2022
9. Effect of diets on digestive enzymes from worker termites of Odontotermes brunneus (Termitidae)
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Muthusamy, R., Gayathri, R., Suresh, K., and Chethan Kumar, T.
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- 2018
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10. OC.14.1 MULTICENTER RETROSPECTIVE INTERNATIONAL STUDY TO EVALUATE OUTCOMES AND SAFETY OF PATIENTS UNDERGOING ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY COMBINING A SINGLE-USE CHOLANGIOSCOPE AND SINGLE-USE DUODENOSCOPE
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Fugazza, A., primary, Colombo, M., additional, Kahaleh, M., additional, Muthusamy, R., additional, Bick, B., additional, Laleman, W., additional, Barbera, C., additional, Fabbri, C., additional, Nieto, J., additional, Allehibi, A., additional, Nageshwar, R., additional, Tyberg, A., additional, Shahid, H., additional, Sarkar, A., additional, Ehrlich, D., additional, Sherman, S., additional, Binda, C., additional, Ramchandani, M., additional, Spadaccini, M., additional, Iannone, A., additional, Anderloni, A., additional, and Repici, A., additional
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- 2022
- Full Text
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11. MULTICENTER RETROSPECTIVE INTERNATIONAL STUDY TO EVALUATE OUTCOMES AND SAFETY OF PATIENTS UNDERGOING ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY COMBINING A SINGLE-USE CHOLANGIOSCOPE AND SINGLE-USE DUODENOSCOPE
- Author
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Fugazza, A., additional, Colombo, M., additional, Kahaleh, M., additional, Muthusamy, R., additional, Bick, B., additional, Laleman, W., additional, Barbera, C., additional, Fabbri, C., additional, Nieto, J., additional, Allehibi, A., additional, Reddy, N., additional, Tyberg, A., additional, Shahid, H., additional, Sarkar, A., additional, Ehrlich, D., additional, Sherman, S., additional, Binda, C., additional, Ramchandani, M., additional, Spadaccini, M., additional, Iannone, A., additional, Anderloni, A., additional, and Repici, A., additional
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- 2022
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12. Fueling a stationary direct injection diesel engine with diesel-used palm oil–butanol blends – An experimental study
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Sharon, H., Jai Shiva Ram, P., Jenis Fernando, K., Murali, S., and Muthusamy, R.
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- 2013
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13. Interactive Case Report: Postoperative Hypoxia In A Woman With Down's Syndrome: Case Outcome
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Siotia, A. K., Chaudhuri, A., Muzulu, S. I., Harling, D., and Muthusamy, R.
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- 2005
14. Commentary: Easy Yet So Easily Missed
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Siotia, A. K. and Muthusamy, R.
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- 2005
15. Interactive Case Report: Postoperative Hypoxia In A Woman With Down's Syndrome: Case Progression
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Siotia, A. K., Chaudhuri, A., Muzulu, S. I., Harling, D., and Muthusamy, R.
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- 2005
16. Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial
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Ray, K, Colhoun, H, Szarek, M, Baccara-Dinet, M, Bhatt, D, Bittner, V, Budaj, A, Diaz, R, Goodman, S, Hanotin, C, Harrington, R, Jukema, J, Loizeau, V, Lopes, R, Moryusef, A, Murin, J, Pordy, R, Ristic, A, Roe, M, Tunon, J, White, H, Zeiher, A, Schwartz, G, Steg, P, Tricoci, P, Mahaffey, K, Edelberg, J, Lecorps, G, Sasiela, W, Tamby, J, Aylward, P, Drexel, H, Sinnaeve, P, Dilic, M, Gotcheva, N, Prieto, J, Yong, H, Lopez-Jaramillo, P, Pecin, I, Reiner, Z, Ostadal, P, Viigimaa, M, Nieminen, M, Chumburidze, V, Marx, N, Danchin, N, Liberopoulos, E, Montenegro Valdovinos, P, Tse, H, Kiss, R, Xavier, D, Zahger, D, Valgimigli, M, Kimura, T, Kim, H, Kim, S, Erglis, A, Laucevicius, A, Kedev, S, Yusoff, K, Ramos Lopez, G, Alings, M, Halvorsen, S, Correa Flores, R, Morais, J, Dorobantu, M, Karpov, Y, Chua, T, Fras, Z, Dalby, A, de Silva, H, Hagstrom, E, Landmesser, U, Chiang, C, Sritara, P, Guneri, S, Parkhomenko, A, Moriarty, P, Vogel, R, Chaitman, B, Kelsey, S, Olsson, A, Rouleau, J, Simoons, 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Y., Tang I-Shing J., Micko K., Nociar J., Pella D., Fulop P., Hranai M., Palka J., Mazur J., Majercak I., Dzupina A., Fazekas F., Gonsorcik J., Bugan V., Selecky J., Kamensky G., Strbova J., Smik R., Dukat A., Zuran I., Poklukar J., Cernic Suligoj N., Cevc M., Cyster H. P., Ranjith N., Corbett C., Bayat J., Makotoko E. M., du Toit Theron H., Kapp I. E., de V Basson M. M., Lottering H., Van Aswegen D., Van Zyl L. J., Sebastian P. J., Pillay T., Saaiman J. A., Commerford P. J., Cassimjee S., Riaz G., Ebrahim I. O., Sarvan M., Mynhardt J. H., Reuter H., Moodley R., Vida M., Cequier Fillat A. R., Bodi Peris V., Fuentes Jimenez F., Marin F., Cruz Fernandez J. M., Hidalgo Urbano R. J., Gil-Extremera B., Toledo P., Worner Diz F., Garcia-Dorado D., Iniguez A., Gonzalez-Juanatey J. R., Fernandez Portales J., Civeira Murillo F., Matas Pericas L., Zamorano J. L., De Mora Martin M., Bruguera Cortada J., Alonso Martin J. J., Serrano Antolin J. M., De Berrazueta Fernandez J. R., Vazquez de Prada J. A., Diaz Fernandez J. F., Garcia Lledo J. A., Cosin Sales J., Botas Rodriguez J., Gusi Tragant G., Benedicto A., Gonzalez-Juanatey C., Camprubi Potau M., Plaza Perez I., De La Tassa C. M., Loma-Osorio Rincon P., Balaguer Recena J., Escudier J. M., Payeras A. C., Alonso Orcajo N., Valdivielso P., Constantine G., Haniffa R., Tissera N., Amarasekera S., Ponnamperuma C., Fernando N., Fernando K., Jayawardena J., Wijeyasingam S., Ranasinghe G., Ekanayaka R., Mendis S., Senaratne V., Mayurathan G., Sirisena T., Rajapaksha A., Herath J. I., Amarasena N., Berglund S., Rasmanis G., Vedin O., Witt N., Mourtzinis G., Nicol P., Hansen O., Romeo S., Agergaard Jensen S., Torstensson I., Ahremark U., Sundelin T., Moccetti T., Muller C., Mach F., Binde R., Tsai W. -C., Ueng K. -C., Lai W. -T., Liu M. -E., Hwang J. -J., Yin W. -H., Hsieh I. -C., Hsieh M. -J., Lin W. H., Kuo J. -Y., Huang T. -Y., Fang C. -Y., Kaewsuwanna P., Soonfuang W., Jintapakorn W., Sukonthasarn A., Wongpraparut N., Sastravaha K., Sansanayudh N., Kehasukcharoen W., Piyayotai D., Chotnoparatpat P., Camsari A., Kultursay H., Mutlu B., Ersanli M., Demirtas M., Kirma C., Ural E., Koldas L., Karpenko O., Prokhorov A., Vakaluyk I., Myshanych H., Reshotko D., Batushkin V., Rudenko L., Kovalskyi I., Kushnir M., Tseluyko V., Mostovoy Y., Stanislavchuk M., Kyiak Y., Karpenko Y., Malynovsky Y., Klantsa A., Kutniy O., Amosova E., Tashchuk V., Leshchuk O., Rishko M., Kopytsya M., Yagensky A., Vatutin M., Bagriy A., Barna O. M., Ushakov O., Dzyak G., Goloborodko B., Rudenko A., Zheleznyy V., Trevelyan J., Zaman A., Lee K., Moriarty A., Aggarwal R. K., Clifford P., Wong Y. -K., Iqbal S. M., Subkovas E., Braganza D., Sarkar D., Storey R., Griffiths H., McClure S., Muthusamy R., Smith S., Kurian J., Levy T., Barr C., Kadr H., Gerber R., Simaitis A., Soran H., Mathur A., Brodison A., Ayaz M., Cheema M., Oliver R., Thackray S., Mudawi T., Rahman G., Sultan A., Sharman D., Sprigings D., Butler R., Wilkinson P., Lip G. Y., Halcox J., Gallagher S., Ossei-Gerning N., Vardi G., Baldari D., Brabham D., Treasure II C., Dahl C., Palmer B., Wiseman A., Puri S., Mohart A. E., Ince C., Flores E., Wright S., Cheng S. -C., Rosenberg M., Rogers W., Kosinski E., Forgosh L., Waltman J., Khan M., Shoukfeh M., Dagher G., Cambier P., Lieber I., Kumar P., East C., Krichmar P., Hasan M., White L., Knickelbine T., Haldis T., Gillespie E., Amidon T., Suh D., Arif I., Abdallah M., Akhter F., Carlson E., D'Urso M., El-Ahdab F., Nelson W., Moriarty K., Harris B., Cohen S., Carter L., Doty D., Sabatino K., Haddad T., Malik A., Rao S., Mulkay A., Jovin I., Klancke K., Malhotra V., Devarapalli S. K., Koren M., Chandna H., Dodds III G., Goraya T., Bengston J., Janik M., Moran J., Sumner A., Kobayashi J., Davis W., Yazdani S., Pasquini J., Thakkar M., Vedere A., Leimbach W., Rider J., Fenton S., Singh N., Shah A. V., Janosik D., Pepine C., Berman B., Gelormini J., Daniels C., Richard K., Keating F., Kondo N. I., Shetty S., Levite H., Waider W., Takata T., Abu-Fadel M., Shah V., Aggarwal R., Izzo M., Kumar A., Hattler B., Do R., Link C., Bortnick A., Kinzfogl III G., Ghitis A., Larry J., Teufel E., Kuhlman P., Mclaurin B., Zhang W., Thew S., Abbas J., White M., Islam O., Subherwal S., Ranadive N., Vakili B., Gring C., Henderson D., Schuchard T., Farhat N., Kline G., Mahal S., Whitaker J., Speirs S., Andersen R., Daboul N., Horwitz P., Zahr F., Ponce G., Jafar Z., Mcgarvey J., Panchal V., Voyce S., Blok T., Sheldon W., Azizad M. M., Schmalfuss C., Picone M., Pederson R., Herzog W., Friedman K., Lindsey J., Nowins R., Timothy E., Leonard P., Lepor N., El Shahawy M., Weintraub H., Irimpen A., Alonso A., May W., Christopher D., Galski T., Chu A., Mody F., Ramin E., Hodes Z., Rossi J., Rose G., Fairlamb J., Lambert C., Raisinghani A., Abbate A., Vetrovec G., King M., Carey C., Gerber J., Younis L., Park H. T., Vidovich M., Knutson T., Friedman D., Chaleff F., Loussararian A., Rozeman P., Kimmelstiel C., Kuvin J., Silver K., Foster M., Tonnessen G., Espinoza A., Amlani M., Wali A., Malozzi C., Jong G. T., Massey C., Wattanakit K., O'Donnell P. J., Singal D., Jaffrani N., Banuru S., Fisher D., Xenakis M., Perlmutter N., Bhagwat R., Strader J., Blonder R., Akyea-Djamson A., Labroo A., Marais H. J., Claxton E., Weiss R., Kathryn R., Berk M., Rossi P., Joshi P., Khera A., Khaira A. S., Kumkumian G., Lupovitch S., Purow J., Welka S., Hoffman D., Fischer S., Soroka E., Eagerton D., Pancholy S., Ray M., Erenrich N., Farrar M., Pollock S., French W. J., Diamantis S., Guy D., Gimple L., Neustel M., Schwartz S., Pereira E., Albert S., Spriggs D., Strain J., Mittal S., Vo A., Chane M., Hall J., Vijay N., Lotun K., Lester F. M., Nahhas A., Pope T., Nager P., Vohra R., Sharma M., Bashir R., Ahmed H., Berlowitz M., Fishberg R., Barrucco R., Yang E., Radin M., Sporn D., Stapleton D., Eisenberg S., Landzberg J., Mcgough M., Turk S., Schwartz M., Sundram P. S., Jain D., Zainea M., Bayron C., Karlsberg R., Dohad S., Lui H., Keen W., Westerhausen D., Khurana S., Agarwal H., Birchem J., Penny W., Chang M., Murphy S., Henry J., Schifferdecker B., Gilbert J. M., Chalavarya G., Eaton C., Schmedtje J. F., Christenson S., Dotani I., Denham D., Macdonell A., Gibson P., Rahman A., Al Joundi T., Assi N., Conrad G., Kotha P., Love M., Giesler G., Rubenstein H., Gamil D., Akright L., Krawczyk J., Cobler J., Wells T., Welker J., Foster R., Gilmore R., Anderson J., Jacoby D., Gardner G., Dandillaya R., Vora K., Kostis J., Hunter J., Laxson D., Ball E., Lopes R., Egydio F., Kawakami A., Oliveira J., Wozniak J., Matthews A., Ratky C., Valiris J., Berdan L., Hepditch A., Quintero K., Rorick T., Westbrook M., Pascual A., Rovito C., Bezault M., Drouet E., Simon T., Alsweiler C., Luyten A., Butters J., Griffith L., Shaw M., Grunberg L., Islam S., Bregeault M. -F., Bougon N., Faustino D., Fontecave S., Murphy J., Verrier M., Agnetti V., Andersen D., Badreddine E., Bekkouche M., Bouancheau C., Brigui I., Brocklehurst M., Cianciarulo J., Devaul D., Domokos S., Gache C., Gobillot C., Guillou S., Healy J., Heath M., Jaiwal G., Javierre C., Labeirie J., Monier M., Morales U., Mrabti A., Mthombeni B., Okan B., Smith L., Sheller J., Sopena S., Pellan V., Benbernou F., Bengrait N., Lamoureux M., Kralova K., Scemama M., Bejuit R., Coulange A., Berthou C., Repincay J., Lorenzato C., Etienne A., Gouet V., Normand M., Ourliac A., Rondel C., Adamo A., Beltran P., Barraud P., Dubois-Gache H., Halle B., Metwally L., Mourgues M., Sotty M., Vincendet M., Cotruta R., Chengyue Z., Fournie-Lloret D., Morrello C., Perthuis A., Picault P., Zobouyan I., Dempsey M. 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P., Hominal M. A., Montana O. R., Caccavo A., Gomez Vilamajo O. A., Lorenzatti A. J., Cartasegna L. R., Paterlini G. A., Mackinnon I. J., Caime G. D., Amuchastegui M., Salomone O., Codutti O. R., Jure H. O., Bono J. O., Hrabar A. D., Vallejos J. A., Ahuad Guerrero R. A., Novoa F., Patocchi C. A., Zaidman C. J., Giuliano M. E., Dran R. D., Vico M. L., Carnero G. S., Guzman P. N., Medrano Allende J. C., Garcia Brasca D. F., Bustamante Labarta M. H., Nani S., Blumberg E. D., Colombo H. R., Liberman A., Fuentealba V., Luciardi H. L., Waisman G. D., Berli M. A., Garcia Duran R. O., Cestari H. G., Luquez H. A., Giordano J. A., Saavedra S. S., Zapata G., Costamagna O., Llois S., Waites J. H., Collins N., Soward A., Hii C. L., Shaw J., Arstall M. A., Horowitz J., Ninio D., Rogers J. F., Colquhoun D., Oqueli Flores R. E., Roberts-Thomson P., Raffel O., Lehman S. J., Aroney C., Coverdale S. G., Garrahy P. J., Starmer G., Sader M., Carroll P. A., Dick R., Zweiker R., Hoppe U., Huber K., Berger R., Delle-Karth G., Frey B., Weidinger F., Faes D., Hermans K., Pirenne B., Leone A., Hoffer E., Vrolix M. C., De Wolf L., Wollaert B., Castadot M., Dujardin K., Beauloye C., Vervoort G., Striekwold H., Convens C., Roosen J., Barbato E., Claeys M., Cools F., Terzic I., Barakovic F., Midzic Z., Pojskic B., Fazlibegovic E., Kulic M., Durak-Nalbantic A., Vulic D., Muslibegovic A., Goronja B., Reis G., Sousa L., Nicolau J. C., Giorgeto F. E., Silva R. P., Nigro Maia L., Rech R., Rossi P. R., Cerqueira M. J. A., Duda N., Kalil R., Kormann A., Abrantes J. A. M., Pimentel Filho P., Soggia A. P., de Santos M. O., Neuenschwander F., Bodanese L. C., Michalaros Y. L., Eliaschewitz F. G., Vidotti M. H., Leaes P. E., Botelho R. V., Kaiser S., Manenti E. R. F., Precoma D. B., Moura Jorge J. C., de B Silva P. G., Silveira J. A., Saporito W., Marin-Neto J. A., Feitosa G. S., Ritt L. E. F., de Souza J. A., Costa F., Souza W. K., Reis H. J., Machado L., Ayoub J. C. A., Todorov G. V., Nikolov F. P., Velcheva E. S., Tzekova M. L., Benov H. O., Petranov S. L., Tumbev H. S., Shehova-Yankova N. S., Markov D. T., Raev D. H., Mollov M. N., Kichukov K. N., Ilieva-Pandeva K. A., Ivanova R., Gospodinov M., Mincheva V. M., Lazov P. V., Dimov B. I., Senaratne M., Stone J., Kornder J., Pearce S., Dion D., Savard D., Pesant Y., Pandey A., Robinson S., Gosselin G., Vizel S., Hoag G., Bourgeois R., Morisset A., Sabbah E., Sussex B., Kouz S., MacDonald P., Diaz A., Michaud N., Fell D., Leung R., Vuurmans T., Lai C., Nigro F., Davies R., Nogareda G., Vijayaraghavan R., Ducas J., Lepage S., Mehta S., Cha J., Dupuis R., Fong P., Lutchmedial S., Rodes-Cabau J., Fadlallah H., Cleveland D., Huynh T., Bata I., Hameed A., Pincetti C., Potthoff S., Prieto J. C., Acevedo M., Aguirre A., Vejar M., Yanez M., Araneda G., Fernandez M., Perez L., Varleta P., Florenzano F., Huidobro L., Raffo C. A., Olivares C., Nahuelpan L., Montecinos H., Chen J., Dong Y., Huang W., Wang J., Huang S. A., Yao Z., Li X., Cui L., Lin W., Sun Y., Li J., Zhang X., Zhu H., Chen D., Huang L., Dong S., Su G., Xu B., Su X., Cheng X., Lin J., Zong W., Li H., Feng Y., Xu D., Yang X., Ke Y., Lin X., Zhang Z., Zheng Z., Luo Z., Chen Y., Ding C., Zhong Y., Zheng Y., Peng D., Zhao S., Li Y., Liu X., Wei M., Liu S., Yu Y., Qu B., Jiang W., Zhou Y., Zhao X., Yuan Z., Guo Y., Xu X., Shi X., Ge J., Fu G., Bai F., Fang W., Shou X., Wang J. A., Xiang M., Lu Q., Zhang R., Zhu J., Xu Y., Fan Z., Li T., Wu C., Jaramillo N., Sanchez Vallejo G., Luna Botia D. C., Botero Lopez R., Molina De Salazar D. I., Cadena Bonfanti A. J., Cotes Aroca C., Diego Higuera J., Blanquicett M., Barrera Silva S. I., Garcia Lozada H. J., Coronel Arroyo J. A., Accini Mendoza J. L., Fernandez Ruiz R. L., Quintero Ossa A. M., Manzur Jatin F. G., Sotomayor Herazo A., Castellanos Parada J., Suarez Arambula R., Urina Triana M. A., Fernandez Trujillo A. M., Strozzi M., Car S., Jeric M., Milicic D., Bencic M. L., Pintaric H., Prvulovic D., Sikic J., Persic V., Mileta D., Stambuk K., Babic Z., Tomulic V., Lukenda J., Mejic-Krstulovic S., Starcevic B., Spinar J., Horak D., Velicka Z., Stasek J., Alan D., Machova V., Linhart A., Novotny V., Kaucak V., Rokyta R., Naplava R., Coufal Z., Adamkova V., Podpera I., Zizka J., Motovska Z., Marusincova I., Svab P., Heinc P., Kuchar J., Povolny P., Matuska J., Poulsen S. H., Raungaard B., Clemmensen P., Bang L. E., May O., Bottcher M., Hove J. D., Frost L., Gislason G., Larsen J., Betton Johansen P., Hald F., Johansen P., Jeppesen J., Nielsen T., Kristensen K. S., Walichiewicz P. M., Lomholdt J. D., Klausen I. C., Nielsen P. K., Davidsen F., Videbaek L., Soots M., Vahula V., Hedman A., Soopold U., Martsin K., Jurgenson T., Kristjan A., Helsinki J. K., Vikman S., Huikuri H., Airaksinen J., Coste P., Ferrari E., Morel O., Montalescot G., Machecourt J., Barone-Rochette G., Mansourati J., Cottin Y., Leclercq F., Belhassane A., Delarche N., Boccara F., Paganelli F., Clerc J., Schiele F., Aboyans V., Probst V., Berland J., Lefevre T., Citron B., Khintibidze I., Shaburishvili T., Pagava Z., Ghlonti R., Lominadze Z., Khabeishvili G., Hemetsberger R., Edward K., Rauch-Krohnert U., Stratmann M., Appel K. -F., Schmidt E., Omran H., Stellbrink C., Dorsel T., Lianopoulos E., Vohringer H. F., Marx R., Zirlik A., Schellenberg D., Heitzer T., Laufs U., Werner C., Gielen S., Nuding S., Winkelmann B., Behrens S., Sydow K., Karakas M., Simonis G., Muenzel T., Werner N., Leggewie S., Bocker D., Braun-Dullaeus R., Toursarkissian N., Jeserich M., Weissbrodt M., Schaeufele T., Weil J., Voller H., Waltenberger J., Natour M., Schmitt S., Muller-Wieland D., Steiner S., Heidenreich L., Offers E., Gremmler U., Killat H., Rieker W., Patsilinakos S., Kartalis A., Manolis A., Sionis D., Chachalis G., Skoumas I., Athyros V., Vardas P., Parthenakis F., Alexopoulos D., Hahalis G., Lekakis J., Hatzitolios A., Fausto Ovando S. R., Arango Benecke J. L., Rodriguez De Leon E. R., Yan B. P., Siu D. C., Turi T., Merkely B., Ungi I., Lupkovics G., Nagy L., Katona A., Edes I., Muller G., Horvath I., Kapin T., Szigeti Z., Falukozy J., Kumbla M., Sandhu M., Annam S., Proddutur N. R., Regella R., Premchand R. K., Mahajan A., Pawar S., Abhyanakar A. D., Kerkar P., Govinda R. A., Oomman A., Sinha D., Patil S. N., Kahali D., Sawhney J., Joshi A. B., Chaudhary S., Harkut P., Guha S., Porwal S., Jujjuru S., Pothineni R. B., Monteiro M. R., Khan A., Iyengar S. S., Grewal J. S., Chopda M., Fulwani M. C., Patange A., Sachin P., Chopra V. K., Goyal N. K., Shinde R., Manakshe G. V., Patki N., Sethi S., Munusamy V., Karna S., Thanvi S., Adhyapak S., Patil C., Pandurangi U., Mathur R., Gupta J., Kalashetti S., Bhagwat A., Raghuraman B., Yerra S. K., Bhansali P., Borse R., Rahul P., Das S., Kumar V., Abdullakutty J., Saathe S., Palimkar P., Sathe S., Atar S., Shechter M., Mosseri M., Arbel Y., Ehud C., Ofer H., Lotan C., Rosenschein U., Katz A., Henkin Y., Francis A., Klutstein M., Nikolsky E., Zukermann R., Turgeman Y., Halabi M., Marmor A., Kornowski R., Jonas M., Amir O., Hasin Y., Rozenman Y., Fuchs S., Zvi V., Hussein O., Gavish D., Vered Z., Caraco Y., Elias M., Tov N., Wolfovitz E., Lishner M., Elias N., Piovaccari G., De Pellegrin A., Garbelotto R., Guardigli G., Marco V., Licciardello G., Auguadro C., Scalise F., Cuccia C., Salvioni A., Musumeci G., Senni M., Calabro P., Novo S., Faggiano P., Metra M., De Cesare N. B., Berti S., Cavallini C., Puccioni E., Galvani M., Tespili M., Piatti P., Palvarini M., De Luca G., Violini R., De Leo A., Olivari Z., Perrone Filardi P., Ferratini M., Racca V., Dai K., Shimatani Y., Kamiya H., Ando K., Takeda Y., Morino Y., Hata Y., Kimura K., Kishi K., Michishita I., Uehara H., Higashikata T., Hirayama A., Hirooka K., Doi Y., Sakagami S., Taguchi S., Koike A., Fujinaga H., Koba S., Kozuma K., Kawasaki T., Ono Y., Shimizu M., Katsuda Y., Wada A., Shinke T., Ako J., Fujii K., Takahashi T., Sakamoto T., Nakao K., Furukawa Y., Sugino H., Tamura R., Mano T., Uematsu M., Utsu N., Ito K., Haraguchi T., Sato K., Ueda Y., Nishibe A., Fujimoto K., Masutani M., Yoon J. H., Kim H. -L., Park H. S., Chae I. -H., Kim M. H., Jeong M. H., Rha S., Kim C., Kim H. -S., Kim H. Y., Hong T., Tahk S. -J., Kim Y., Busmane A., Pontaga N., Strelnieks A., Mintale I., Sime I., Petrulioniene Z., Kavaliauskiene R., Jurgaitiene R., Sakalyte G., Slapikas R., Norkiene S., Misonis N., Kibarskis A., Kubilius R., Bojovski S., Lozance N., Kjovkaroski A., Doncovska S., Ong T. K., Kasim S., Maskon O., Kandasamy B., Liew H. B., Wan Mohamed W. M. I., Garcia Castillo A., Carrillo Calvillo J., Fajardo Campos P., Nunez Fragoso J. C., Bayram Llamas E. A., Alcocer Gamba M. A., Carranza Madrigal J., Gonzalez Salas L. G., Lopez Rosas E., Gonzalez Diaz B., Salcido Vazquez E., Nacoud Ackar A., Llamas Esperon G. A., Martinez Sanchez C. R., Guerrero De Leon M., Suarez Otero R., Fanghanel Salmon G., Perez Rios J. A., Garza Ruiz J. A., Breedveld R. W., Feenema-Aardema M., Borger-Van Der Burg A., Hoogslag P. A., Suryapranata H., Oomen A., Van Haelst P., Wiersma J. J., Basart D., Van Der Wal R. M., Zwart P., Monraats P., Van Kesteren H., Karalis I., Jukema J., Verdel G. J., Brueren B. R., Troquay R. P., Viergever E. P., Al-Windy N. Y., Bartels G. L., Cornel J. H., Hermans W. R., Herrman J. P., Bos R. J., Groutars R. G., Van Der Zwaan C. C., Kaplan R., Lionarons R., Ronner E., Groenemeijer B. E., Bronzwaer P. N., Liem A. A., Rensing B. J., Bokern M. J., Nijmeijer R., Hersbach F. M., Willems F. F., Gosselink A. T., Rasoul S., Elliott J., Wilkins G., Fisher R., Scott D., Hart H., Stewart R., Harding S., Ternouth I., Fisher N., Wilson S., Aitken D., Anscombe R., Davidson L., Tomala T., Nygard O., Sparby J. A., Andersen K., Gullestad L., Jortveit J., Munk P. S., Singsaas E. G., Hurtig U., Calderon Ticona J. R., Durand Velasquez J. R., Negron Miguel S. A., Sanabria Perez E. S., Carrion Chambilla J. M., Chavez Ayala C. A., Castillo Leon R. P., Vargas Gonzales R. J., Hernandez Zuniga J. D., Camacho Cosavalente L. A., Bravo Mannucci J. E., Heredia Landeo J., Llerena Navarro N. C., Roldan Concha Y. M., Rodriguez Chavez V. E., Anchante Hernandez H. A., Zea Nunez C. A., Mogrovejo Ramos W., Ferrolino A., Sy R. A. G., Tirador L., Sy R. G., Matiga G., Coching R. M., Bernan A., Rogelio G., Morales D. D., Tan E., Sulit D. J., Wlodarczak A., Jaworska K., Skonieczny G., Pawlowicz L., Wojewoda P., Busz-Papiez B., Bednarski J., Goch A., Staneta P., Dulak E., Saminski K., Krasowski W., Sudnik W., Zurakowski A., Skorski M., Miklaszewicz B., Kubica J., Andrzej Lipko J., Kostarska-Srokosz E., Piepiorka M., Drzewiecka A., Stasiewski A., Blicharski T., Bystryk L., Szpajer M., Korol M., Czerski T., Mirek-Bryniarska E., Gniot J., Lubinski A., Gorny J., Franek E., Raczak G., Szwed H., Monteiro P., Mesquita Bastos J., Pereira H. H., Martins D., Seixo F., Mendonca C., Botelho A., Caetano F., Minescu B., Istratoaie O., Tesloianu D. N., Cristian G., Dumitrescu S., Podoleanu C. G., Constantinescu M. C., Bengus C. M., Militaru C., Rosu D., Parepa I. R., Matei A. V., Alexandru T. M., Malis M., Coman I., Stanescu-Cioranu R., Dimulescu D., Shvarts Y., Orlikova O., Kobalava Z., Barbarash O. L., Markov V., Lyamina N., Gordienko A., Zrazhevsky K., Vishnevsky A. Y., Gurevich V., Stryuk R., Lomakin N. V., Bokarev I., Khlevchuk T., Shalaev S., Khaisheva L., Chizhov P., Viktorova I., Osokina N., Shchekotov V., Akatova E., Chumakova G., Libov I., Voevoda M. I., Tretyakova T. V., Baranov E., Shustov S., Yakushin S., Gordeev I., Khasanov N., Reshetko O., Sotnikova T., Molchanova O., Nikolaev K., Gapon L., Baranova E., Shogenov Z., Kosmachova E., Povzun A., Egorova L., Tyrenko V. V., Ivanov I. G., Ilya M., Kanorsky S., Simic D., Ivanovic N., Davidovic G., Tasic N., Asanin M. R., Stojic S., Apostolovic S. R., Ilic S., Putnikovic Tosic B., Stankovic A., Arandjelovic A., Radovanovic S., Todic B., Balinovac J., Dincic D. V., Seferovic P., Karadzic A., Dodic S., Dimkovic S., Jakimov T., Poh K. -K., Ong H. Y., Tang I-Shing J., Micko K., Nociar J., Pella D., Fulop P., Hranai M., Palka J., Mazur J., Majercak I., Dzupina A., Fazekas F., Gonsorcik J., Bugan V., Selecky J., Kamensky G., Strbova J., Smik R., Dukat A., Zuran I., Poklukar J., Cernic Suligoj N., Cevc M., Cyster H. P., Ranjith N., Corbett C., Bayat J., Makotoko E. M., du Toit Theron H., Kapp I. E., de V Basson M. M., Lottering H., Van Aswegen D., Van Zyl L. J., Sebastian P. J., Pillay T., Saaiman J. A., Commerford P. J., Cassimjee S., Riaz G., Ebrahim I. O., Sarvan M., Mynhardt J. H., Reuter H., Moodley R., Vida M., Cequier Fillat A. R., Bodi Peris V., Fuentes Jimenez F., Marin F., Cruz Fernandez J. M., Hidalgo Urbano R. J., Gil-Extremera B., Toledo P., Worner Diz F., Garcia-Dorado D., Iniguez A., Gonzalez-Juanatey J. R., Fernandez Portales J., Civeira Murillo F., Matas Pericas L., Zamorano J. L., De Mora Martin M., Bruguera Cortada J., Alonso Martin J. J., Serrano Antolin J. M., De Berrazueta Fernandez J. R., Vazquez de Prada J. A., Diaz Fernandez J. F., Garcia Lledo J. A., Cosin Sales J., Botas Rodriguez J., Gusi Tragant G., Benedicto A., Gonzalez-Juanatey C., Camprubi Potau M., Plaza Perez I., De La Tassa C. M., Loma-Osorio Rincon P., Balaguer Recena J., Escudier J. M., Payeras A. C., Alonso Orcajo N., Valdivielso P., Constantine G., Haniffa R., Tissera N., Amarasekera S., Ponnamperuma C., Fernando N., Fernando K., Jayawardena J., Wijeyasingam S., Ranasinghe G., Ekanayaka R., Mendis S., Senaratne V., Mayurathan G., Sirisena T., Rajapaksha A., Herath J. I., Amarasena N., Berglund S., Rasmanis G., Vedin O., Witt N., Mourtzinis G., Nicol P., Hansen O., Romeo S., Agergaard Jensen S., Torstensson I., Ahremark U., Sundelin T., Moccetti T., Muller C., Mach F., Binde R., Tsai W. -C., Ueng K. -C., Lai W. -T., Liu M. -E., Hwang J. -J., Yin W. -H., Hsieh I. -C., Hsieh M. -J., Lin W. H., Kuo J. -Y., Huang T. -Y., Fang C. -Y., Kaewsuwanna P., Soonfuang W., Jintapakorn W., Sukonthasarn A., Wongpraparut N., Sastravaha K., Sansanayudh N., Kehasukcharoen W., Piyayotai D., Chotnoparatpat P., Camsari A., Kultursay H., Mutlu B., Ersanli M., Demirtas M., Kirma C., Ural E., Koldas L., Karpenko O., Prokhorov A., Vakaluyk I., Myshanych H., Reshotko D., Batushkin V., Rudenko L., Kovalskyi I., Kushnir M., Tseluyko V., Mostovoy Y., Stanislavchuk M., Kyiak Y., Karpenko Y., Malynovsky Y., Klantsa A., Kutniy O., Amosova E., Tashchuk V., Leshchuk O., Rishko M., Kopytsya M., Yagensky A., Vatutin M., Bagriy A., Barna O. M., Ushakov O., Dzyak G., Goloborodko B., Rudenko A., Zheleznyy V., Trevelyan J., Zaman A., Lee K., Moriarty A., Aggarwal R. K., Clifford P., Wong Y. -K., Iqbal S. M., Subkovas E., Braganza D., Sarkar D., Storey R., Griffiths H., McClure S., Muthusamy R., Smith S., Kurian J., Levy T., Barr C., Kadr H., Gerber R., Simaitis A., Soran H., Mathur A., Brodison A., Ayaz M., Cheema M., Oliver R., Thackray S., Mudawi T., Rahman G., Sultan A., Sharman D., Sprigings D., Butler R., Wilkinson P., Lip G. Y., Halcox J., Gallagher S., Ossei-Gerning N., Vardi G., Baldari D., Brabham D., Treasure II C., Dahl C., Palmer B., Wiseman A., Puri S., Mohart A. E., Ince C., Flores E., Wright S., Cheng S. -C., Rosenberg M., Rogers W., Kosinski E., Forgosh L., Waltman J., Khan M., Shoukfeh M., Dagher G., Cambier P., Lieber I., Kumar P., East C., Krichmar P., Hasan M., White L., Knickelbine T., Haldis T., Gillespie E., Amidon T., Suh D., Arif I., Abdallah M., Akhter F., Carlson E., D'Urso M., El-Ahdab F., Nelson W., Moriarty K., Harris B., Cohen S., Carter L., Doty D., Sabatino K., Haddad T., Malik A., Rao S., Mulkay A., Jovin I., Klancke K., Malhotra V., Devarapalli S. K., Koren M., Chandna H., Dodds III G., Goraya T., Bengston J., Janik M., Moran J., Sumner A., Kobayashi J., Davis W., Yazdani S., Pasquini J., Thakkar M., Vedere A., Leimbach W., Rider J., Fenton S., Singh N., Shah A. V., Janosik D., Pepine C., Berman B., Gelormini J., Daniels C., Richard K., Keating F., Kondo N. I., Shetty S., Levite H., Waider W., Takata T., Abu-Fadel M., Shah V., Aggarwal R., Izzo M., Kumar A., Hattler B., Do R., Link C., Bortnick A., Kinzfogl III G., Ghitis A., Larry J., Teufel E., Kuhlman P., Mclaurin B., Zhang W., Thew S., Abbas J., White M., Islam O., Subherwal S., Ranadive N., Vakili B., Gring C., Henderson D., Schuchard T., Farhat N., Kline G., Mahal S., Whitaker J., Speirs S., Andersen R., Daboul N., Horwitz P., Zahr F., Ponce G., Jafar Z., Mcgarvey J., Panchal V., Voyce S., Blok T., Sheldon W., Azizad M. M., Schmalfuss C., Picone M., Pederson R., Herzog W., Friedman K., Lindsey J., Nowins R., Timothy E., Leonard P., Lepor N., El Shahawy M., Weintraub H., Irimpen A., Alonso A., May W., Christopher D., Galski T., Chu A., Mody F., Ramin E., Hodes Z., Rossi J., Rose G., Fairlamb J., Lambert C., Raisinghani A., Abbate A., Vetrovec G., King M., Carey C., Gerber J., Younis L., Park H. T., Vidovich M., Knutson T., Friedman D., Chaleff F., Loussararian A., Rozeman P., Kimmelstiel C., Kuvin J., Silver K., Foster M., Tonnessen G., Espinoza A., Amlani M., Wali A., Malozzi C., Jong G. T., Massey C., Wattanakit K., O'Donnell P. J., Singal D., Jaffrani N., Banuru S., Fisher D., Xenakis M., Perlmutter N., Bhagwat R., Strader J., Blonder R., Akyea-Djamson A., Labroo A., Marais H. J., Claxton E., Weiss R., Kathryn R., Berk M., Rossi P., Joshi P., Khera A., Khaira A. S., Kumkumian G., Lupovitch S., Purow J., Welka S., Hoffman D., Fischer S., Soroka E., Eagerton D., Pancholy S., Ray M., Erenrich N., Farrar M., Pollock S., French W. J., Diamantis S., Guy D., Gimple L., Neustel M., Schwartz S., Pereira E., Albert S., Spriggs D., Strain J., Mittal S., Vo A., Chane M., Hall J., Vijay N., Lotun K., Lester F. M., Nahhas A., Pope T., Nager P., Vohra R., Sharma M., Bashir R., Ahmed H., Berlowitz M., Fishberg R., Barrucco R., Yang E., Radin M., Sporn D., Stapleton D., Eisenberg S., Landzberg J., Mcgough M., Turk S., Schwartz M., Sundram P. S., Jain D., Zainea M., Bayron C., Karlsberg R., Dohad S., Lui H., Keen W., Westerhausen D., Khurana S., Agarwal H., Birchem J., Penny W., Chang M., Murphy S., Henry J., Schifferdecker B., Gilbert J. M., Chalavarya G., Eaton C., Schmedtje J. F., Christenson S., Dotani I., Denham D., Macdonell A., Gibson P., Rahman A., Al Joundi T., Assi N., Conrad G., Kotha P., Love M., Giesler G., Rubenstein H., Gamil D., Akright L., Krawczyk J., Cobler J., Wells T., Welker J., Foster R., Gilmore R., Anderson J., Jacoby D., Gardner G., Dandillaya R., Vora K., Kostis J., Hunter J., Laxson D., Ball E., Lopes R., Egydio F., Kawakami A., Oliveira J., Wozniak J., Matthews A., Ratky C., Valiris J., Berdan L., Hepditch A., Quintero K., Rorick T., Westbrook M., Pascual A., Rovito C., Bezault M., Drouet E., Simon T., Alsweiler C., Luyten A., Butters J., Griffith L., Shaw M., Grunberg L., Islam S., Bregeault M. -F., Bougon N., Faustino D., Fontecave S., Murphy J., Verrier M., Agnetti V., Andersen D., Badreddine E., Bekkouche M., Bouancheau C., Brigui I., Brocklehurst M., Cianciarulo J., Devaul D., Domokos S., Gache C., Gobillot C., Guillou S., Healy J., Heath M., Jaiwal G., Javierre C., Labeirie J., Monier M., Morales U., Mrabti A., Mthombeni B., Okan B., Smith L., Sheller J., Sopena S., Pellan V., Benbernou F., Bengrait N., Lamoureux M., Kralova K., Scemama M., Bejuit R., Coulange A., Berthou C., Repincay J., Lorenzato C., Etienne A., Gouet V., Normand M., Ourliac A., Rondel C., Adamo A., Beltran P., Barraud P., Dubois-Gache H., Halle B., Metwally L., Mourgues M., Sotty M., Vincendet M., Cotruta R., Chengyue Z., Fournie-Lloret D., Morrello C., Perthuis A., Picault P., Zobouyan I., Dempsey M. A., and McClanahan M. A.
- Abstract
Background: After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1·4–1·8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue in a prespecified analysis of the ODYSSEY OUTCOMES trial of the PCSK9 inhibitor alirocumab, assessing its effects on cardiovascular outcomes by baseline glycaemic status, while also assessing its effects on glycaemic measures including risk of new-onset diabetes. Methods: ODYSSEY OUTCOMES was a randomised, double-blind, placebo-controlled trial, done at 1315 sites in 57 countries, that compared alirocumab with placebo in patients who had been admitted to hospital with an acute coronary syndrome (myocardial infarction or unstable angina) 1–12 months before randomisation and who had raised concentrations of atherogenic lipoproteins despite use of high-intensity statins. Patients were randomly assigned (1:1) to receive alirocumab or placebo every 2 weeks; randomisation was stratified by country and was done centrally with an interactive voice-response or web-response system. Alirocumab was titrated to target LDL cholesterol concentrations of 0·65–1·30 mmol/L. In this prespecified analysis, we investigated the effect of alirocumab on cardiovascular events by glycaemic status at baseline (diabetes, prediabetes, or normoglycaemia)—defined on the basis of patient history, review of medical records, or baseline HbA1c or fasting serum glucose—and risk of new-onset diabetes among those without diabetes at baseline. The primary endpoint was a composite of death from coronary heart disease, non-fatal myocardial infarction, fatal or non-fatal ischaemic stroke, or unstable angina requiring
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- 2019
17. Prevalence of Simkania negevensis in chlorinated water from spa swimming pools and domestic supplies
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Donati, M., Cremonini, E., Di Francesco, A., Dallolio, L., Biondi, R., Muthusamy, R., and Leoni, E.
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- 2015
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18. Evaluation of biochemical and antioxidant properties of crude extracts from the Indian cattle leech Poecilobdella granulosa.
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Padmanaban, D., Muthusamy, R. G., Sahayanathan, G. J., Raja, K., and Chinnasamy, A.
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ANTIOXIDANTS ,LEECHES ,OXIDATIVE stress ,FREE radicals ,SUPEROXIDES - Abstract
Oxidative stress is one of the factors influencing the structure and function of cells, tissues, and their components. Natural antioxidants have emerged as prophylactic and therapeutic agents for diseases like cancer and cardiovascular disease. The objective of the current study is to assess the biochemical composition and antioxidant potential of crude extracts from various organs of the Indian cattle leech Poecilobdella granulosa. The biochemical constituents and protein profiles of various crude samples were determined by Native and SDS polyacrylamide gel electrophoresis. Moreover, four different crude samples were subjected to check free radical scavenging activity. In the biochemical analysis, protein and carbohydrate content were found to be higher in whole-body extract and several major and minor bands were found ranging from 22 to 110 kDa during qualitative analysis. Interestingly, among the four crude samples, saliva alone showed antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl and superoxide anion radical scavenging activity. This study concluded that the crude saliva extract from P. granulosa is a highly selective and effective antioxidant for human welfare. [ABSTRACT FROM AUTHOR]
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- 2022
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19. Biochemical Estimation in an Acute Toxicity Study of Narayana Chenduram- A Siddha Formulation
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Sukala, PM, primary, Muthusamy, R, additional, Tamilalagan, V, additional, Baskaran, S, additional, and Choudhary, Arbind Kumar, additional
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- 2021
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20. Endoscopic ablation of intestinal metaplasia containing high-grade dysplasia in esophagectomy patients using a balloon-based ablation system
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Smith, C. D., Bejarano, P. A., Melvin, W S., Patti, M. G., Muthusamy, R., and Dunkin, B. J.
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- 2007
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21. Surveillance of bacterial pneumonia and other invasive bacterial diseases among under-five children in India, 2016–2018
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Girish Kumar, C.P., primary, Sukumar, B., additional, Veeraraghavan, B., additional, Gajendran, S., additional, Daniel, J.L., additional, Varghese, R., additional, Rajkumar, P., additional, Kangusamy, B., additional, Muthusamy, R., additional, and Jayaraman, Y., additional
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- 2020
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22. Poster session Thursday 6 December – AM: Other myocardial diseases
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Vijayan, S, Miller, H, Muthusamy, R, and Smith, SMG
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- 2012
23. On the Thermal Unfolding Character of Globular Proteins
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Muthusamy, R., Gromiha, M. Michael, and Ponnuswamy, P. K.
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- 2000
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24. Phytochemical Profile of Aloe Barbadensis and their Proficiency in Defluoridation of Fluoride Contaminated Water
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Manopradesh, M., primary, Mathiyazhagan, N., additional, Gajendiran, K., additional, Muthusamy, R., additional, Suresh, K., additional, and Selvam, R., additional
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- 2019
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25. Gli oli essenziali di Monarda fistulosa e Monarda didyma inibiscono l’infettività dei virus Herpes simplex I e II in vitro
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Muthusamy R., Bellardi M. G., Mattarelli P., Ripalti A., and Muthusamy R., Bellardi M.G., Mattarelli P., Ripalti A.
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Monarda didyma, Monarda fistulosa, Herpes simplex, Antivirali - Abstract
I virus Herpes simplex (HSV) 1 e 2, comunemente noti come herpes labiale e genitale, sono molto diffusi nella popolazione umana e la loro sieroprevalenza può arrivare fino al 90% in popolazioni sfavorite dal punto di vista socioeconomico. Le infezioni da HSV possono decorrere asintomatiche o essere gravissime, per esempio in ambito perinatale, nel soggetto immunodepresso, o quando coinvolgono l’encefalo. Più comunemente provocano lesioni dolorose e ricorrenti con un forte impatto negativo sulla vita di relazione dei pazienti. Non si dispone di un vaccino contro HSV, mentre i farmaci disponibili possono controllare le fasi acute dell’infezione ma non portano all’eradicazione dei virus. Inoltre il loro ampio uso favorisce l’insorgenza di ceppi resistenti, in particolare in pazienti immunocompromessi. E’ dunque importante individuare nuovi approcci di profilassi e/o terapia con l’intento di affiancare alle molecole in uso composti con meccanismi d’azione alternativi. Scopo. Valutare la capacità degli olii essenziali (OE) estratti da Monarda spp. di contrastare il ciclo vitale dei virus HSV-1 e HSV-2. Materiali e metodi. Cellule: abbiamo utilizzato la linea cellulare di astrocitoma U-373 MG per tutti gli esperimenti di infettività, mentre le line Vero (per HSV-1) e BHK (per HSV-2) sono state impiegate per la titolazione dei virus. I virus utilizzati sono stati un isolato clinico di HSV-1, il mutante replicazione competente K26GFP, che esprime la proteina fluorescente GFP e il ceppo di laboratorio HSV-2 (G). Infine sono stati impiegati OE di Monarda fistulosa, M. didyma e Melaleuca alternifolia. Saggi di attività antivirale sono stati effettuati nelle seguenti condizioni: (a) preincubazione virus/OE, (b) preincubazione monostrati cellulari con /OE, (c) aggiunta degli OE successiva all’adsorbimento virale su cellule preincubate con gli olii, (d) aggiunta degli OE dopo adsorbimento con virus preincubato con gli olii, (e) aggiunta degli OE subito dopo l’adsorbimento di virus. Le cellule venivano fissate ai tempi 3, 6, 9, 12, 18, 24 e 48 ore post infectionem. Il grado di replicazione virale veniva giudicato in confronto a cellule non trattate infettate con virus non trattato, osservando la comparsa di proteine virus specifiche o contando le placche da effetto citopatico. Risultati. Abbiamo osservato un forte effetto virucida degli OE delle due specie di Monarda su HSV-1 e 2, più potente di quello noto per M. alternifolia. Gli OE non sono invece in grado di contrastare la replicazione virale una volta che i virus siano penetrati nelle cellule. Conclusioni. Il potere virucida di questi OE si pone come un promettente presidio per prevenire l’infezione e contenere la diffusione del virus. La disponibilità di molecole in grado di agire su fasi distinte del ciclo replicativo virale offre la possibilità di ridurre le dosi dei farmaci utilizzati di concerto e la durata del trattamento, minimizzando i rischi d’insorgenza di virus resistenti e di effetti indesiderati.
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- 2018
26. Effects of Alirocumab on Cardiovascular Events After Coronary Bypass Surgery
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Szarek, M, Bhatt, DL, Bittner, VA, Diaz, R, Edelberg, JM, Hanotin, C, Harrington, RA, Jukema, JW, Letierce, A, Moryusef, A, Pordy, R, Lopez, GAR, Roe, MT, White, HD, Zeiher, AM, Steg, PG, Schwartz, GG, Aylward, PE, Drexel, H, Sinnaeve, P, Dilic, M, Goodman, SG, Prieto, JC, Yong, H, Lopez-Jaramillo, P, Pecin, I, Reiner, Z, Ostadal, P, Poulsen, SH, Viigimaa, M, Nieminen, MS, Danchin, N, Chumburidze, V, Tse, HF, Xavier, D, Zahger, D, Valgimigli, M, Kimura, T, Kim, HS, Kim, SH, Erglis, A, Laucevicius, A, Kedev, S, Yusoff, K, Alings, M, Halvorsen, S, Flores, RMC, Sy, RG, Budaj, A, Morais, J, Dorobantu, M, Karpov, Y, Ristic, AD, Chua, T, Murin, J, Fras, Z, Tunon, J, de Silva, HA, Muller, C, Ray, KK, Vogel, R, Chaitman, B, Kelsey, SF, Olsson, AG, Rouleau, JL, Simoons, ML, Alexander, K, Meloni, C, Rosenson, R, Sijbrands, EJG, Alexander, JH, Armaganijan, L, Bagai, A, Bahit, MC, Brennan, JM, Clifton, S, DeVore, AD, Deloatch, S, Dickey, S, Dombrowski, K, Ducrocq, G, Eapen, Z, Endsley, P, Eppinger, A, Hess, CN, Hlatky, MA, Jordan, JD, Knowles, JW, Kolls, BJ, Kong, DF, Leonardi, S, Lillis, L, Maron, DJ, Marcus, J, Mathews, R, Mehta, RH, Mentz, RJ, Moreira, HG, Patel, CB, Pereira, SB, Perkins, L, Povsic, TJ, Puymirat, E, Jones, WS, Shah, BR, Sherwood, MW, Stringfellow, K, Sujjavanich, D, Toma, M, Trotter, C, van Diepen, SFP, Wilson, MD, Yan, ATK, Schiavi, LB, Garrido, M, Alvarisqueta, AF, Sassone, SA, Bordonava, AP, De Lima, AEA, Schmidberg, JM, Duronto, EA, Caruso, OC, Novaretto, LP, Hominal, MA, Montana, OR, Caccavo, A, Vilamajo, OAG, Lorenzatti, AJ, Cartasegna, LR, Paterlini, GA, Mackinnon, IJ, Caime, GD, Amuchastegui, M, Codutti, OR, Jure, HO, Bono, JOE, Hrabar, AD, Vallejos, JA, Rodolfo, AAG, Novoa, F, Patocchi, CA, Zaidman, CJ, Giuliano, ME, Dran, RD, Vico, ML, Carnero, GS, Guzman, PN, Allende, JCM, Brasca, DFG, Labarta, MHB, Nani, S, Blumberg, EDS, Colombo, HR, Liberman, A, Luciardi, HL, Waisman, GD, Berli, MA, Duran, ROG, Cestari, HG, Luquez, HA, Giordano, JA, Saavedra, SS, Waites, JH, Collins, N, Soward, A, Hii, CLS, Shaw, J, Arstall, MA, Horowitz, J, Rogers, JF, Colquhoun, D, Flores, REO, Roberts-Thomson, P, Raffel, O, Lehman, SJ, Coverdale, SGM, Garrahy, PJ, Starmer, G, Sader, M, Carroll, PA, Zweiker, R, Hoppe, U, Huber, K, Berger, R, Weidinger, F, Faes, D, Hermans, K, Pirenne, B, Leone, A, Hoffer, E, Vrolix, MCM, De Wolf, L, Wollaert, B, Castadot, M, Dujardin, K, Beauloye, C, Vervoort, G, Striekwold, H, Convens, C, Roosen, J, Barbato, E, Claeys, M, Cools, F, Terzic, I, Barakovic, F, Midzic, Z, Pojskic, B, Fazlibegovic, E, Durak-Nalbantic, A, Vulic, D, Muslibegovic, A, Reis, G, Sousa, L, Nicolau, JC, Giorgeto, FE, Silva, RP, Maia, LN, Rech, R, Rossi, PRF, Cerqueira, MJAG, Duda, N, Kalil, R, Kormann, A, Abrantes, JAM, Pimentel, P, Soggia, AP, de Santos, MON, Neuenschwander, F, Bodanese, LC, Michalaros, YL, Eliaschewitz, FG, Vidotti, MH, Leaes, PE, Botelho, RV, Kaiser, S, Manenti, ERFF, Precoma, DB, Jorge, JCM, Silva, PGMD, Silveira, JA, Saporito, W, Marin, JA, Feitosa, GS, Ritt, LEF, de Souza, JA, Costa, F, Souza, WKSB, Reis, HJL, Lopes, RD, Machado, L, Ayoub, JCA, Todorov, GV, Nikolov, FP, Velcheva, ES, Tzekova, ML, Benov, HO, Petranov, SL, Tumbev, HS, Shehova-Yankova, NS, Markov, DT, Raev, DH, Mollov, MN, Kichukov, KN, Ilieva-Pandeva, KA, Gotcheva, NN, Ivanova, R, Mincheva, VM, Lazov, PV, Dimov, BI, Senaratne, M, Stone, J, Kornder, J, Pearce, S, Dion, D, Savard, D, Pesant, Y, Pandey, A, Robinson, S, Gosselin, G, Vizel, S, Hoag, G, Bourgeois, R, Morisset, A, Sabbah, E, Sussex, B, Kouz, S, MacDonald, P, Diaz, A, Michaud, N, Fell, D, Leung, R, Vuurmans, T, Lai, C, Nigro, F, Davies, R, Nogareda, G, Vijayaraghavan, R, Ducas, J, Lepage, S, Mehta, S, Cha, J, Dupuis, R, Fong, P, Rodes-Cabau, J, Fadlallah, H, Cleveland, D, Huynh, T, Bata, I, Hameed, A, Pincetti, C, Potthoff, S, Acevedo, M, Aguirre, A, Vejar, M, Yanez, M, Araneda, G, Fernandez, M, Perez, L, Varleta, P, Florenzano, F, Huidobro, L, Raffo, CA, Olivares, C, Chen, JY, Dong, YG, Huang, WJ, Wang, JZ, Huang, SA, Yao, ZH, Cui, L, Lin, WH, Sun, YM, Wang, JF, Li, JP, Zhang, XL, Zhu, H, Chen, DD, Huang, L, Dong, SH, Su, GH, Xu, B, Su, X, Cheng, XS, Lin, JX, Zong, WX, Li, HM, Feng, Y, Xu, DL, Yang, XC, Ke, YN, Lin, XF, Zhang, Z, Zheng, ZQ, Luo, ZR, Chen, YD, Ding, CH, Zheng, Y, Li, XD, Peng, DQ, Li, Y, Wei, M, Liu, SW, Yu, YH, Qu, BM, Jiang, WH, Zhou, YJ, Zhao, XS, Yuan, ZY, Guo, Y, Xu, XP, Shi, XB, Ge, JB, Fu, GS, Bai, F, Fang, WY, Shou, XL, Yang, XJ, Wang, JA, Jaramillo, N, Vallejo, GS, Botia, DCL, Lopez, RB, De Salazar, DIM, Bonfanti, AJC, Higuera, JD, Silva, SIB, Lozada, HJG, Arroyo, JAC, Mendoza, JLA, Ruiz, RLF, Fernandez, AM, Jatin, FGM, Herazo, AS, Parada, JC, Triana, MAU, Spinar, J, Horak, D, Stasek, J, Alan, D, Machova, V, Linhart, A, Novotny, V, Kaucak, V, Rokyta, R, Naplava, R, Coufal, Z, Adamkova, V, Podpera, I, Zizka, J, Motovska, Z, Marusincova, I, Svab, P, Heinc, P, Kuchar, J, Povolny, P, Raungaard, B, Clemmensen, P, Bang, LE, May, O, Bottcher, M, Hove, JD, Frost, L, Gislason, G, Larsen, J, Johansen, PB, Hald, F, Jeppesen, J, Nielsen, T, Kristensen, KS, Walichiewicz, PM, Lomholdt, JD, Klausen, IC, Nielsen, PK, Davidsen, F, Videbaek, L, Soots, M, Vahula, V, Hedman, A, Soopold, U, Martsin, K, Taskinen, MR, Porthan, K, Airaksinen, JK, Juonala, M, Kiviniemi, T, Vikman, S, Posio, P, Taurio, J, Huikuri, H, Kaikkonen, K, Coste, P, Ferrari, E, Morel, O, Montalescot, G, Barone-Rochette, G, Mansourati, J, Cottin, Y, Leclercq, F, Belhassane, A, Delarche, N, Boccara, F, Paganelli, F, Clerc, J, Schiele, F, Aboyans, V, Probst, V, Berland, J, Lefevre, T, Khintibidze, I, Shaburishvili, T, Pagava, Z, Ghlonti, R, Lominadze, Z, Khabeishvili, G, Hemetsberger, R, Rauch-Krohnert, U, Stratmann, M, Appel, KF, Schmidt, E, Omran, H, Stellbrink, C, Dorsel, T, Lianopoulos, E, Marx, R, Zirlik, A, Schellenberg, D, Heitzer, T, Laufs, U, Marx, N, Gielen, S, Winkelmann, B, Behrens, S, Sydow, K, Simonis, G, Muenzel, T, Werner, N, Leggewie, S, Bocker, D, Braun-Dullaeus, R, Toursarkissian, N, Jeserich, M, Weissbrodt, M, Schaeufele, T, Weil, J, Voller, H, Waltenberger, J, Natour, M, Steiner, S, Heidenreich, L, Gremmler, U, Killat, H, Patsilinakos, S, Kartalis, A, Manolis, A, Sionis, D, Liberopoulos, E, Skoumas, I, Athyros, V, Parthenakis, PIF, Hahalis, PIG, Lekakis, J, Xatzitolios, A, Ovando, SRF, Valdovinos, PCM, Benecke, JLA, De Leon, ERR, Yan, BPY, Siu, DCW, Turi, T, Merkely, B, Kiss, RG, Ungi, I, Lupkovics, G, Nagy, L, Katona, A, Edes, I, Muller, G, Horvath, I, Kapin, T, Falukozy, J, Kumbla, M, Sandhu, M, Annam, S, Proddutur, NR, Premchand, RK, Mahajan, A, Abhyanakar, AD, Kerkar, P, Govinda, RA, Oomman, A, Sinha, D, Patil, SN, Kahali, D, Sawhney, J, Joshi, AB, Chaudhary, S, Harkut, P, Guha, S, Porwal, S, Jujjuru, S, Pothineni, RB, Monteiro, MR, Khan, A, Iyengar, SS, Grewal, JS, Chopda, M, Fulwani, MC, Patange, A, Chopra, VK, Goyal, NK, Shinde, R, Manakshe, GV, Patki, N, Sethi, S, Munusamy, V, Karna, S, Adhyapak, S, Pandurangi, U, Mathur, R, Kalashetti, S, Bhagwat, A, Raghuraman, B, Yerra, SK, Bhansali, P, Borse, R, Das, S, Abdullakutty, J, Saathe, S, Palimkar, P, Atar, S, Shechter, M, Mosseri, M, Arbel, Y, Lotan, C, Rosenschein, U, Katz, A, Henkin, Y, Francis, A, Klutstein, M, Nikolsky, E, Turgeman, Y, Halabi, M, Kornowski, R, Jonas, M, Amir, O, Rozenman, Y, Fuchs, S, Hussein, O, Gavish, D, Vered, Z, Caraco, Y, Elias, M, Tov, N, Piovaccari, G, De Pellegrin, A, Guardigli, G, Licciardello, G, Auguadro, C, Cuccia, C, Salvioni, A, Musumeci, G, Calabro, P, Novo, S, Faggiano, P, De Cesare, NB, Berti, S, Cavallini, C, Puccioni, E, Galvani, M, Tespili, M, Piatti, P, Palvarini, M, De Luca, G, Violini, R, De Leo, A, Filardi, PP, Ferratini, M, Dai, K, Kamiya, H, Ando, K, Takeda, Y, Morino, Y, Hata, Y, Kimura, K, Kishi, K, Michishita, I, Uehara, H, Higashikata, T, Hirayama, A, Hirooka, K, Sakagami, S, Taguchi, S, Koike, A, Fujinaga, H, Koba, S, Kozuma, K, Kawasaki, T, Ono, Y, Shimizu, M, Katsuda, Y, Wada, A, Shinke, T, Ako, J, Fujii, K, Takahashi, T, Sakamoto, T, Furukawa, Y, Sugino, H, Mano, T, Utsu, N, Ito, K, Haraguchi, T, Ueda, Y, Nishibe, A, Fujimoto, K, Yoon, JH, Park, HS, Chae, IH, Kim, MH, Jeong, MH, Rha, S, Kim, C, Hong, T, Busmane, A, Pontaga, N, Strelnieks, A, Mintale, I, Sime, I, Petrulioniene, Z, Kavaliauskiene, R, Jurgaitiene, R, Sakalyte, G, Slapikas, R, Norkiene, S, Misonis, N, Kibarskis, A, Kubilius, R, Bojovski, S, Lozance, N, Kjovkaroski, A, Doncovska, S, Ong, TK, Kasim, S, Maskon, O, Kandasamy, B, Liew, HB, Mohamed, WMIW, Castillo, AG, Calvillo, JC, Campos, PF, Fragoso, JCN, Llamas, EAB, Gamba, MAA, Madrigal, JC, Salas, LGG, Rosas, EL, Diaz, BG, Vazquez, ES, Ackar, AN, Esperon, GAL, Sanchez, CRM, De Leon, MG, Otero, RS, Salmon, GF, Rios, JAP, Ruiz, JAG, Breedveld, RW, Hoogslag, PAM, Suryapranata, H, Oomen, A, Wiersma, JJ, Van Der Wal, RMA, Van Huysduynen-Monraats, PSH, Karalis, I, Verdel, GJE, Brueren, BRG, Troquay, RPT, Viergever, EP, Al-Windy, NYY, Bartels, GL, Cornel, JH, Hermans, WRM, Herrman, JPR, Bos, RJ, Groutars, RGEJ, Van Der Zwaan, CC, Kaplan, R, Ronner, E, Groenemeijer, BE, Bronzwaer, PNA, Liem, AAH, Rensing, BJWM, Bokern, MJJA, Nijmeijer, R, Hersbach, FMRJ, Willems, FF, Gosselink, ATM, Elliott, J, Wilkins, G, Fisher, R, Scott, D, Hart, H, Stewart, R, Harding, S, Ternouth, I, Fisher, N, Aitken, D, Anscombe, R, Tomala, T, Nygard, O, Sparby, JA, Andersen, K, Gullestad, L, Jortveit, J, Munk, PS, Hurtig, U, Ticona, JRC, Velasquez, JRD, Miguel, SAN, Perez, ESS, Chambilla, JMC, Ayala, CAC, Leon, RPC, Gonzales, RJV, Zuniga, JDH, Cosavalente, LAC, Mannucci, JEB, Navarro, NCL, Concha, YMR, Chavez, VER, Hernandez, HAA, Nunez, CAZ, Ferrolino, A, Sy, RAG, Tirador, L, Matiga, G, Coching, RM, Bernan, A, Rogelio, G, Morales, DD, Tan, E, Wlodarczak, A, Jaworska, K, Skonieczny, G, Pawlowicz, L, Wojewoda, P, Busz-Papiez, B, Bednarski, J, Goch, A, Staneta, P, Dulak, E, Saminski, K, Krasowski, W, Sudnik, W, Zurakowski, A, Skorski, M, Lysek, R, Miklaszewicz, B, Kubica, J, Lipko, JA, Kostarska-Srokosz, E, Piepiorka, M, Drzewiecka, A, Sciborski, R, Stasiewski, A, Blicharski, T, Bystryk, L, Szpajer, M, Korol, M, Czerski, T, Mirek-Bryniarska, E, Gniot, J, Lubinski, A, Gorny, J, Franek, E, Monteiro, P, Bastos, JM, Pereira, HH, Martins, D, Seixo, F, Mendonca, C, Botelho, A, Minescu, B, Istratoaie, O, Tesloianu, DN, Cristian, G, Podoleanu, CGC, Constantinescu, MCA, Bengus, CM, Militaru, C, Rosu, D, Parepa, IR, Matei, AV, Alexandru, TM, Shvarts, Y, Orlikova, O, Kobalava, Z, Barbarash, OL, Markov, V, Lyamina, N, Gordienko, A, Zrazhevsky, K, Vishnevsky, AY, Gurevich, V, Stryuk, R, Lomakin, NV, Bokarev, I, Shalaev, S, Khaisheva, L, Chizhov, P, Viktorova, I, Osokina, N, Akatova, E, Chumakova, G, Libov, I, Voevoda, MI, Tretyakova, TV, Baranov, E, Shustov, S, Yakushin, S, Gordeev, I, Khasanov, N, Reshetko, O, Sotnikova, T, Molchanova, O, Nikolaev, K, Gapon, L, Baranova, E, Shogenov, Z, Kosmachova, E, Povzun, A, Egorova, L, Tyrenko, VV, Ivanov, IG, Simic, D, Ivanovic, N, Davidovic, G, Tasic, N, Asanin, MR, Stojic, S, Apostolovic, SR, Ilic, S, Putnikovic, B, Stankovic, A, Arandjelovic, A, Radovanovic, S, Balinovac, J, Dincic, DV, Seferovic, P, Dodic, S, Dimkovic, S, Poh, KK, Ong, HY, Micko, K, Nociar, J, Pella, D, Fulop, P, Hranai, M, Palka, J, Mazur, J, Majercak, I, Dzupina, A, Fazekas, F, Gonsorcik, J, Bugan, V, Selecky, J, Kamensky, G, Strbova, J, Smik, R, Dukat, A, Zuran, I, Oklukar, J, Suligoj, NC, Cevc, M, Lipar, L, Cyster, HP, Ranjith, N, Corbett, C, Bayat, J, Makotoko, EM, Kapp, IE, Basson, MMD, Lottering, H, Van Zyl, LJ, Sebastian, PJ, Pillay, T, Saaiman, JA, Commerford, PJ, Cassimjee, S, Ebrahim, IO, Sarvan, M, Mynhardt, JH, Dalby, AJ, Reuter, H, Moodley, R, Vida, M, Fillat, ARC, Peris, VB, Jimenez, FF, Marin, F, Fernandez, JMC, Gil-Extremera, B, Diz, FW, Garcia-Dorado, D, Iniguez, A, Fernandez, JT, Gonzalez-Juanatey, JR, Portales, JF, Murillo, FC, Pericas, LM, Zamorano, JL, Martin, MD, Cortada, JB, Martin, 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Myshanych, H, Reshotko, D, Batushkin, V, Rudenko, L, Kovalskyi, I, Kushnir, M, Tseluyko, V, Mostovoy, Y, Stanislavchuk, M, Kyiak, Y, Karpenko, Y, Malynovsky, Y, Klantsa, A, Kutniy, O, Amosova, E, Tashchuk, V, Leshchuk, O, Parkhomenko, A, Rishko, M, Kopytsya, M, Yagensky, A, Vatutin, M, Bagriy, A, Barna, OM, Ushakov, O, Dzyak, G, Goloborodko, B, Rudenko, A, Trevelyan, J, Zaman, A, Lee, K, Moriarty, A, Aggarwal, RK, Clifford, P, Wong, YK, Iqbal, SMR, Subkovas, E, Braganza, D, Sarkar, D, Storey, R, Griffiths, H, Mcclure, S, Muthusamy, R, Kurian, J, Levy, T, Barr, C, Kadr, H, Gerber, R, Simaitis, A, Soran, H, Mathur, A, Brodison, A, Oliver, R, Mudawi, T, Reynolds, T, Sharman, D, Butler, R, Wilkinson, P, Lip, GYH, Halcox, J, Vardi, G, Baldari, D, Brabham, D, Treasure, C, Dahl, C, Palmer, B, Wiseman, A, Puri, S, Mohart, AE, Ince, C, Flores, E, Wright, S, Cheng, SC, Rosenberg, M, Rogers, W, Kosinski, E, Forgosh, L, Waltman, J, Khan, M, Shoukfeh, M, Dagher, G, Lieber, I, Kumar, P, East, C, Krichmar, P, White, L, Knickelbine, T, Haldis, T, Gillespie, E, Suh, D, Arif, I, Akhter, F, Carlson, E, D'Urso, M, El-Ahdab, F, Nelson, W, Harris, B, Cohen, S, Carter, L, Sabatino, K, Haddad, T, Malik, A, Rao, S, Mulkay, A, Jovin, I, Klancke, K, Malhotra, V, Devarapalli, SK, Koren, M, Chandna, H, Dodds, G, Janik, M, Moran, J, Sumner, A, Kobayashi, J, Davis, W, Yazdani, S, Pasquini, J, Thakkar, M, Vedere, A, Leimbach, W, Rider, J, Singh, N, Shah, AV, Moriarty, PM, Janosik, D, Pepine, C, Berman, B, Gelormini, J, Daniels, C, Keating, F, Kondo, NI, Shetty, S, Waider, W, Takata, T, Abu-Fadel, M, Shah, V, Aggarwal, R, Izzo, M, Kumar, A, Hattler, B, Link, C, Bortnick, A, Kinzfogl, G, Ghitis, A, Larry, J, Teufel, E, Kuhlman, P, Mclaurin, B, Zhang, WW, Thew, S, Abbas, J, White, M, Ranadive, N, Gring, C, Henderson, D, Schuchard, T, Farhat, N, Kline, G, Mahal, S, Whitaker, J, Speirs, S, Andersen, R, Daboul, N, Horwitz, P, Jafar, Z, Mcgarvey, J, Panchal, V, Voyce, S, Blok, T, Sheldon, W, Azizad, MM, Schmalfuss, C, Picone, M, Herzog, W, Lindsey, J, Nowins, R, Lepor, N, El Shahawy, M, Weintraub, H, Irimpen, A, May, W, Galski, T, Chu, A, Mody, F, Hodes, Z, Fairlamb, J, Lambert, C, Raisinghani, A, Abbate, A, King, M, Carey, C, Gerber, J, Younis, L, Park, H, Vidovich, M, Knutson, T, Friedman, D, Chaleff, F, Loussararian, A, Kimmelstiel, C, Silver, K, Foster, M, Tonnessen, G, Amlani, M, Wali, A, Malozzi, C, Wattanakit, K, O'Donnell, PJ, Singal, D, Jaffrani, N, Banuru, S, Fisher, D, Xenakis, M, Perlmutter, N, Bhagwat, R, Strader, J, Akyea-Djamson, A, Labroo, A, Marais, HJ, Claxton, E, Berk, M, Rossi, P, Joshi, P, Khaira, AS, Kumkumian, G, Lupovitch, S, Purow, J, Welka, S, Hoffman, D, Fischer, S, Soroka, E, Eagerton, D, Pancholy, S, Ray, M, Farrar, M, Pollock, S, French, WJ, Diamantis, S, Gimple, L, Schwartz, S, Pereira, E, Spriggs, D, Strain, J, Vo, A, Chane, M, Hall, J, Vijay, N, Lotun, K, Lester, FM, Nahhas, A, Pope, T, Nager, P, Vohra, R, Bashir, R, Ahmed, H, Berlowitz, M, Fishberg, R, Barrucco, R, Yang, E, Radin, M, Sporn, D, Eisenberg, S, Landzberg, J, Mcgough, M, Turk, S, Schwartz, M, Sundram, PS, Jain, D, Zainea, M, Bayron, C, Karlsberg, R, Lui, H, Keen, W, Westerhausen, D, Khurana, S, Agarwal, H, Birchem, J, Penny, W, Chang, M, Gilbert, JM, Chalavarya, G, Eaton, C, Schmedtje, JF, Christenson, S, Denham, D, Macdonell, A, Gibson, P, Rahman, A, Al Joundi, T, Conrad, G, Kotha, P, Love, M, Giesler, G, Rubenstein, H, Akright, L, Schifferdecker, B, Krawczyk, J, Wells, T, Welker, J, Foster, R, Gilmore, R, Anderson, J, Jacoby, D, Gardner, G, Dandillaya, R, Vora, K, Kostis, J, Hunter, J, Laxson, D, Ball, E, İÜC, and Ege Üniversitesi
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Male ,medicine.medical_specialty ,Acute coronary syndrome ,alirocumab ,030204 cardiovascular system & hematology ,Antibodies, Monoclonal, Humanized ,lipids ,PCSK9 ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Double-Blind Method ,coronary artery bypass graft ,Internal medicine ,medicine ,Humans ,Cardiac and Cardiovascular Systems ,030212 general & internal medicine ,Myocardial infarction ,cardiovascular diseases ,Acute Coronary Syndrome ,Coronary Artery Bypass ,Alirocumab ,Aged ,Kardiologi ,business.industry ,Unstable angina ,Hazard ratio ,cholesterol ,Middle Aged ,medicine.disease ,surgical procedures, operative ,Bypass surgery ,Cardiovascular Diseases ,Cardiology ,Drug Therapy, Combination ,Female ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Cardiology and Cardiovascular Medicine ,business ,Mace - Abstract
Sherwood, Matthew/0000-0002-4305-5883; Taskinen, Marja-Riitta/0000-0002-6229-3588; Leonardi, Sergio/0000-0002-4800-6132; Raffel, Owen C/0000-0001-5470-7050; Muenzel, Thomas/0000-0001-5503-4150; Ersanli, Murat/0000-0003-1847-3087; Gislason, Gunnar H/0000-0002-0548-402X; bastos, jose/0000-0002-9526-3123; Abbate, Antonio/0000-0002-1930-785X; Chumakova, Galina A/0000-0002-2810-6531; Nikolaev, Konstantin/0000-0003-4601-6203; Tse, Hung Fat/0000-0002-9578-7808; Keskin, Kudret/0000-0002-9049-1530; Reshetko, Olga/0000-0003-3107-7636; Podoleanu, Cristian/0000-0001-9987-2519; Aylward, Philip/0000-0002-5358-8552; LETIERCE, Alexia/0000-0001-6679-5772, WOS: 000483334800002, PubMed: 31466614, BACKGROUND Patients with acute coronary syndrome (ACS) and history of coronary artery bypass grafting (CABG) are at high risk for recurrent cardiovascular events and death. OBJECTIVES This study sought to determine the clinical benefit of adding alirocumab to statins in ACS patients with prior CABG in a pre-specified analysis of ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab). METHODS Patients (n = 18,924) 1 to 12 months post-ACS with elevated atherogenic lipoprotein levels despite high-intensity statin therapy were randomized to alirocumab or placebo subcutaneously every 2 weeks. Median follow-up was 2.8 years. the primary composite endpoint of major adverse cardiovascular events (MACE) comprised coronary heart disease death, nonfatal myocardial infarction, ischemic stroke, or unstable angina requiring hospitalization. All-cause death was a secondary endpoint. Patients were categorized by CABG status: no CABG (n = 16,896); index CABG after qualifying ACS, but before randomization (n = 1,025); or CABG before the qualifying ACS (n = 1,003). RESULTS in each CABG category, hazard ratios (95% confidence intervals) for MACE (no CABG 0.86 [0.78 to 0.95], index CABG 0.85 [0.54 to 1.35], prior CABG 0.77 [0.61 to 0.98]) and death (0.88 [ 0.75 to 1.03], 0.85 [0.46 to 1.59], 0.67 [0.44 to 1.01], respectively) were consistent with the overall trial results (0.85 [ 0.78 to 0.93] and 0.85 [0.73 to 0.98], respectively). Absolute risk reductions (95% confidence intervals) differed across CABG categories for MACE (no CABG 1.3% [0.5% to 2.2%], index CABG 0.9% [-2.3% to 4.0%], prior CABG 6.4% [0.9% to 12.0%]) and for death (0.4% [-0.1% to 1.0%], 0.5% [-1.9% to 2.9%], and 3.6% [0.0% to 7.2%]). CONCLUSIONS Among patients with recent ACS and elevated atherogenic lipoproteins despite intensive statin therapy, alirocumab was associated with large absolute reductions in MACE and death in those with CABG preceding the ACS event. (ODYSSEY OUTCOMES: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab; NCT01663402) (C) 2019 by the American College of Cardiology Foundation., Fondation Assistance Publique-Hopitaux de Paris, Paris, France, The authors thank the patients, study coordinators, and investigators who participated in this trial. Sophie Rushton-Smith, PhD (MedLink Healthcare Communications, London) provided editorial assistance in the preparation of the manuscript (limited to editing for style, referencing, and figure and table editing) and was funded by Fondation Assistance Publique-Hopitaux de Paris, Paris, France.
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- 2019
27. Effect of Alirocumab on Mortality After Acute Coronary Syndromes An Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial
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DIM, Bonfanti, AJC, Higuera, JD, Silva, SIB, Lozada, HJG, Arroyo, JAC, Mendoza, JLA, Ruiz, RLF, Jatin, FGM, Herazo, AS, Parada, JC, Triana, MAU, Strozzi, M, Car, S, Milicic, D, Bencic, ML, Pintaric, H, Prvulovic, D, Sikic, J, Persic, V, Mileta, D, Stambuk, K, Zdravko, B, Tomulic, V, Krstulovic, SM, Starcevic, B, Spinar, J, Horak, D, Stasek, J, Alan, D, Machova, V, Linhart, A, Novotny, V, Kaucak, V, Rokyta, R, Naplava, R, Coufal, Z, Adamkova, V, Podpera, I, Zizka, J, Motovska, Z, Marusincova, I, Svab, P, Heinc, P, Kuchar, J, Povolny, P, Matuska, J, Raungaard, B, Clemmensen, P, Bang, LE, May, O, Bottcher, M, Hove, JD, Frost, L, Gislason, G, Larsen, J, Johansen, PB, Hald, F, Jeppesen, J, Nielsen, T, Kristensen, KS, Walichiewicz, PM, Lomholdt, JD, Klausen, IC, Nielsen, PK, Davidsen, F, Videbaek, L, Soots, M, Vahula, V, Hedman, A, Soopold, U, Martsin, K, Kristjan, A, Taskinen, M-R, Porthan, K, Airaksinen, JK, Juonala, M, Kiviniemi, T, Vikman, S, Posio, P, Taurio, J, Huikuri, H, Kaikkonen, K, Coste, P, Ferrari, E, Morel, O, Montalescot, G, Barone-Rochette, G, Mansourati, J, Cottin, Y, Leclercq, F, Belhassane, A, Delarche, N, Boccara, F, Paganelli, F, Clerc, J, Schiele, F, Aboyans, V, Probst, V, Berland, J, Lefevre, T, Citron, B, Khintibidze, I, Shaburishvili, T, Pagava, Z, Ghlonti, R, Lominadze, Z, Khabeishvili, G, Hemetsberger, R, Rauch-Kroehnert, U, Stratmann, M, Appel, K-F, Schmidt, E, Omran, H, Stellbrink, C, Dorsel, T, Lianopoulos, E, Marx, R, Zirlik, A, Schellenberg, D, Heitzer, T, Laufs, U, Gielen, S, Winkelmann, B, Behrens, S, Sydow, K, Simonis, G, Muenzel, T, Werner, N, Leggewie, S, Boecker, D, Braun-Dullaeus, R, Toursarkissian, N, Jeserich, M, Weissbrodt, M, Schaeufele, T, Weil, J, Voeller, H, Waltenberger, J, Natour, M, Schmitt, S, Steiner, S, Heidenreich, L, Gremmler, U, Killat, H, Rieker, W, Patsilinakos, S, Kartalis, A, Manolis, A, Sionis, D, Skoumas, I, Athyros, V, Vardas, P, Parthenakis, F, Alexopoulos, D, Hahalis, G, Lekakis, J, Hatzitolios, A, Ovando, SRF, Benecke, JLA, De Leon, ERR, Yan, BPY, Siu, DCW, Turi, T, Merkely, B, Ungi, I, Lupkovics, G, Nagy, L, Katona, A, Edes, I, Muller, G, Horvath, I, Kapin, T, Falukozy, J, Kumbla, M, Sandhu, M, Annam, S, Proddutur, NR, Premchand, RK, Mahajan, A, Abhyanakar, AD, Kerkar, P, Govinda, RA, Oomman, A, Sinha, D, Patil, SN, Kahali, D, Sawhney, J, Joshi, AB, Chaudhary, S, Harkut, P, Guha, S, Porwal, S, Jujjuru, S, Pothineni, RB, Monteiro, MR, Khan, A, Iyengar, SS, Grewal, JS, Chopda, M, Fulwani, MC, Patange, A, Chopra, VK, Goyal, NK, Shinde, R, Manakshe, GV, Patki, N, Sethi, S, Munusamy, V, Karna, S, Adhyapak, S, Pandurangi, U, Mathur, R, Kalashetti, S, Bhagwat, A, Raghuraman, B, Yerra, SK, Bhansali, P, Borse, R, Das, S, Abdullakutty, J, Saathe, S, Palimkar, P, Abdullkutty, J, Sathe, S, Atar, S, Shechter, M, Mosseri, M, Arbel, Y, Lotan, C, Rosenschein, U, Katz, A, Henkin, Y, Francis, A, Klutstein, M, Nikolsky, E, Turgeman, Y, Halabi, M, Kornowski, R, Jonas, M, Amir, O, Rozenman, Y, Fuchs, S, Hussein, O, Gavish, D, Vered, Z, Caraco, Y, Elias, M, Tov, N, Lishner, M, Elias, N, Piovaccari, G, De Pellegrin, A, Guardigli, G, Licciardello, G, Auguadro, C, Cuccia, C, Salvioni, A, Musumeci, G, Calabro, P, Novo, S, Faggiano, P, De Cesare, NB, Berti, S, Cavallini, C, Puccioni, E, Galvani, M, Tespili, M, Piatti, P, Palvarini, M, De Luca, G, Violini, R, De Leo, A, Filardi, PP, Ferratini, M, Ricca, V, Dai, K, Kamiya, H, Ando, K, Takeda, Y, Morino, Y, Hata, Y, Kimura, K, Kishi, K, Michishita, I, Uehara, H, Higashikata, T, Hirayama, A, Hirooka, K, Sakagami, S, Taguchi, S, Koike, A, Fujinaga, H, Koba, S, Kozuma, K, Kawasaki, T, Ono, Y, Shimizu, M, Katsuda, Y, Wada, A, Shinke, T, Ako, J, Fujii, K, Takahashi, T, Sakamoto, T, Furukawa, Y, Sugino, H, Mano, T, Utsu, N, Ito, K, Haraguchi, T, Ueda, Y, Nishibe, A, Fujimoto, K, Masutani, M, Yoon, JH, Park, HS, Chae, I-H, Kim, MH, Jeong, MH, Rha, S, Kim, C, Kim, H-S, Hong, T, Tahk, S-J, Kim, Y, Busmane, A, Pontaga, N, Strelnieks, A, Mintale, I, Sime, I, Petrulioniene, Z, Kavaliauskiene, R, Jurgaitiene, R, Sakalyte, G, Slapikas, R, Norkiene, S, Misonis, N, Kibarskis, A, Kubilius, R, Bojovski, S, Lozance, N, Kjovkaroski, A, Doncovska, S, Ong, TK, Kasim, S, Maskon, O, Kandasamy, B, Liew, HB, Mohamed, WMIW, Garcia Castillo, A, Carrillo Calvillo, J, Fajardo Campos, P, Nunez Fragoso, JC, Bayram Llamas, EA, Alcocer Gamba, MA, Carranza Madrigal, J, Gonzalez Salas, LG, Lopez Rosas, E, Gonzalez Diaz, B, Salcido Vazquez, E, Nacoud Ackar, A, Llamas Esperon, GA, Martinez Sanchez, CR, Guerrero De Leon, M, Suarez Otero, R, Fanghanel Salmon, G, Perez Rios, JA, Garza Ruiz, JA, Breedveld, RW, Hoogslag, PAM, Suryapranata, H, Oomen, A, Wiersma, JJ, Van Der Wal, RMA, Van Huysduynen-Monraats, PSH, Karalis, I, Verdel, GJE, Brueren, BRG, Troquay, RP, Viergever, EP, Al-Windy, NYY, Bartels, GL, Cornel, JH, Hermans, WRM, Herrman, JPR, Bos, RJ, Groutars, RGEJ, Van Der Zwaan, CC, Kaplan, R, Ronner, E, Groenemeijer, BE, Bronzwaer, PNA, Liem, AAH, Rensing, BJWM, Bokern, MJJA, Nijmeijer, R, Hersbach, FMRJ, Willems, FF, Gosselink, ATM, Elliott, J, Wilkins, G, Fisher, R, Scott, D, Hart, H, Stewart, R, Harding, S, Ternouth, I, Fisher, N, Aitken, D, Anscombe, R, Davidson, L, Tomala, T, Nygard, O, Sparby, JA, Andersen, K, Gullestad, L, Jortveit, J, Munk, PS, Singsaas, EG, Hurtig, U, Calderon Ticona, JR, Durand Velasquez, JR, Negron Miguel, SA, Sanabria Perez, ES, Carrion Chambilla, JM, Chavez Ayala, CA, Castillo Leon, RP, Vargas Gonzales, RJ, Hernandez Zuniga, JD, Camacho Cosavalente, LA, Bravo Mannucci, JE, Heredia Landeo, J, Llerena Navarro, NC, Roldan Concha, YM, Rodriguez Chavez, V-CE, Anchante Hernandez, HA, Zea Nunez, CA, Mogrovejo Ramos, W, Ferrolino, A, Sy, RAG, Tirador, L, Matiga, G, Coching, RM, Bernan, A, Rogelio, G, Morales, DD, Tan, E, Sulit, DJ, Wlodarczak, A, Jaworska, K, Skonieczny, G, Pawlowicz, L, Wojewod, P, Busz-Papiez, B, Bednarski, J, Goch, A, Staneta, P, Dulak, E, Saminsk, K, Krasowski, W, Sudnik, W, Zurakowski, A, Skorski, M, Lysek, R, Miklaszewicz, B, Kubica, J, Lipko, JA, Kostarska-Srokosz, E, Piepiorka, M, Drzewiecka, A, Sciborski, R, Stasiewski, A, Blicharski, T, Bystryk, L, Szpajer, M, Korol, M, Czerski, T, Mirek-Bryniarska, E, Gniot, J, Lubinski, A, Gorny, J, Franek, E, Raczak, G, Szwed, H, Monteiro, P, Bastos, JM, Pereira, HH, Martins, D, Seixo, F, Mendonca, C, Botelho, A, Minescu, B, Istratoaie, O, Tesloianu, DN, Cristian, G, Podoleanu, CGC, Constantinescu, MCA, Bengus, CM, Militaru, C, Rosu, D, Parepa, IR, Matei, AV, Alexandru, TM, Coman, I, Cioranu, RS, Dimulescu, D, Shvarts, Y, Orlikova, O, Kobalava, Z, Barbarash, OL, Markov, V, Lyamina, N, Gordienko, A, Zrazhevsky, K, Vishnevsky, AY, Gurevich, V, Stryuk, R, Lomakin, NV, Bokarev, I, Shalaev, S, Khaisheva, L, Chizhov, P, Viktorova, I, Osokina, N, Akatova, E, Chumakova, G, Libov, I, Voevoda, MI, Tretyakova, TV, Baranov, E, Shustov, S, Yakushin, S, Gordeev, I, Khasanov, N, Reshetko, O, Sotnikova, T, Molchanova, O, Nikolaev, K, Gapon, L, Baranova, E, Shogenov, Z, Kosmachova, E, Povzun, A, Egorova, L, Tyrenko, VV, Ivanov, IG, Kanorsky, S, Simic, D, Ivanovic, N, Davidovic, G, Tasic, N, Asanin, MR, Stojic, S, Apostolovic, SR, Ilic, S, Putnikovic, B, Stankovic, A, Arandjelovic, A, Radovanovic, S, Balinovac, J, Dincic, DV, Seferovic, P, Dodic, S, Dimkovic, S, Poh, K-K, Ong, HY, Micko, K, Nociar, J, Pella, D, Fulop, P, Hranai, M, Palka, J, Mazur, J, Majercak, I, Dzupina, A, Fazekas, F, Gonsorcik, J, Bugan, V, Selecky, J, Kamensky, G, Strbova, J, Smik, R, Dukat, A, Olexa, P, Zuran, I, Poklukar, J, Suligoj, NC, Cevc, M, Cyster, HP, Ranjith, N, Corbett, C, Bayat, J, Makotoko, EM, Kapp, IE, Basson, MMDV, Lottering, H, Van Zyl, LJ, Sebastian, PJ, Pillay, T, Saaiman, JA, Commerford, PJ, Cassimjee, S, Ebrahim, IO, Sarvan, M, Mynhardt, JH, Reuter, H, Moodley, R, Vida, M, Cequier Fillat, AR, Peris, VB, Jimenez, FF, Marin, F, Cruz Fernandez, JM, Gil-Extremera, B, Diz, FW, Garcia-Dorado, D, Iniguez, A, Tunon Fernandez, J, Gonzalez-Juanatey, JR, Fernandez Portales, J, Civeira Murillo, F, Matas Pericas, L, Luis Zamorano, J, De Mora Martin, M, Bruguera Cortada, J, Alonso Martin, JJ, De Berrazueta Fernandez, JR, Diaz Fernandez, JF, Garcia Lledo, JA, Cosin Sales, J, Botas Rodriguez, J, Gusi Tragant, G, Benedicto, A, Gonzalez-Juanatey, C, Camprubi Potau, M, Plaza Perez, I, Moris De La Tassa, C, Loma-Osorio Rincon, P, Balaguer Recena, J, Escudier, JM, Coca Payeras, A, Alonso Orcajo, N, Valdivielso, P, Constantine, G, Haniffa, R, Tissera, N, Amarasekera, S, Fernando, N, Jayawardena, J, Santharaj, W, Ekanayaka, R, Mendis, S, Senaratne, V, Mayurathan, G, Sirisena, T, Rajapaksha, A, Herath, JI, Amarasena, N, Berglund, S, Rasmanis, G, Witt, N, Mourtzinis, G, Nicol, P, Hansen, O, Romeo, S, Jensen, SA, Torstensson, I, Ahremark, U, Sundelin, T, Moccetti, T, Mach, F, Binder, R, Tsai, W-C, Ueng, K-C, Lai, W-T, Liu, M-E, Hwang, J-J, Yin, W-H, Hsieh, I-C, Lin, WH, Kuo, J-Y, Huang, T-Y, Fang, C-Y, Kaewsuwanna, P, Soonfuang, W, Jintapakorn, W, Sukonthasarn, A, Wongpraparut, N, Sastravaha, K, Sansanayudh, N, Kehasukcharoen, W, Piyayotai, D, Chotnoparatpat, P, Camsari, A, Kultursay, H, Mutlu, B, Ersanli, M, Demirtas, M, Kirma, C, Ural, E, Koldas, L, Karpenko, O, Prokhorov, A, Vakaluyk, I, Myshanych, H, Reshotko, D, Batushkin, V, Rudenko, L, Kovalskyi, I, Kushnir, M, Tseluyko, V, Mostovoy, Y, Stanislavchuk, M, Kyiak, Y, Karpenko, Y, Malynovsky, Y, Klantsa, A, Kutniy, O, Amosova, E, Tashchuk, V, Leshchuk, O, Rishko, M, Kopytsya, M, Yagensky, A, Vatutin, M, Bagriy, A, Barna, OM, Ushakov, O, Dzyak, G, Goloborodko, B, Rudenko, A, Zheleznyy, V, Trevelyan, J, Zaman, A, Lee, K, Moriarty, A, Aggarwal, RK, Clifford, P, Wong, Y-K, Iqbal, SMR, Subkovas, E, Braganza, D, Sarkar, D, Storey, R, Griffiths, H, Mcclure, S, Muthusamy, R, Kurian, J, Levy, T, Barr, C, Kadr, H, Gerber, R, Simaitis, A, Soran, H, Mathur, A, Brodison, A, Oliver, R, Mudawi, T, Reynolds, T, Sharman, D, Butler, R, Wilkinson, P, Lip, GYH, Halcox, J, Vardi, G, Baldari, D, Brabham, D, Treasure, C, Dahl, C, Palmer, B, Wiseman, A, Puri, S, Mohart, AE, Ince, C, Flores, E, Wright, S, Cheng, S-C, Rosenberg, M, Rogers, W, Kosinski, E, Forgosh, L, Waltman, J, Khan, M, Shoukfeh, M, Dagher, G, Lieber, I, Kumar, P, East, C, Krichmar, P, White, L, Knickelbine, T, Haldis, T, Gillespie, E, Suh, D, Arif, I, Akhter, F, Carlson, E, D'Urso, M, El-Ahdab, F, Nelson, W, Harris, B, Cohen, S, Carter, L, Sabatino, K, Haddad, T, Malik, A, Rao, S, Mulkay, A, Jovin, I, Klancke, K, Malhotra, V, Devarapalli, SK, Koren, M, Chandna, H, Dodds, G, Janik, M, Moran, J, Sumner, A, Kobayashi, J, Davis, W, Yazdani, S, Pasquini, J, Thakkar, M, Vedere, A, Leimbach, W, Rider, J, Singh, N, Shah, AV, Janosik, D, Pepine, C, Berman, B, Gelormini, J, Daniels, C, Keating, F, Kondo, NI, Shetty, S, Waider, W, Takata, T, Abu-Fadel, M, Shah, V, Aggarwal, R, Izzo, M, Kumar, A, Hattler, B, Link, C, Bortnick, A, Kinzfogl, G, Ghitis, A, Larry, J, Teufel, E, Kuhlman, P, Mclaurin, B, Zhang, W, Thew, S, Abbas, J, White, M, Ranadive, N, Gring, C, Henderson, D, Schuchard, T, Farhat, N, Kline, G, Mahal, S, Whitaker, J, Speirs, S, Andersen, R, Daboul, N, Horwitz, P, Ponce, G, Jafar, Z, Mcgarvey, J, Panchal, V, Voyce, S, Blok, T, Sheldon, W, Azizad, MM, Schmalfuss, C, Picone, M, Herzog, W, Lindsey, J, Nowins, R, Lepor, N, El Shahawy, M, Weintraub, H, Irimpen, A, May, W, Galski, T, Chu, A, Mody, F, Hodes, Z, Rose, G, Fairlamb, J, Lambert, C, Raisinghani, A, Abbate, A, King, M, Carey, C, Gerber, J, Younis, L, Park, HT, Vidovich, M, Knutson, T, Friedman, D, Chaleff, F, Loussararian, A, Rozeman, P, Kimmelstiel, C, Silver, K, Foster, M, Tonnessen, G, Amlani, M, Wali, A, Malozzi, C, Wattanakit, K, O'Donnell, PJ, Singal, D, Jaffrani, N, Banuru, S, Fisher, D, Xenakis, M, Perlmutter, N, Bhagwat, R, Strader, J, Akyea-Djamson, A, Labroo, A, Marais, HJ, Claxton, E, Berk, M, Rossi, P, Joshi, P, Khaira, AS, Kumkumian, G, Lupovitch, S, Purow, J, Welka, S, Hoffman, D, Fischer, S, Soroka, E, Eagerton, D, Pancholy, S, Ray, M, Farrar, M, Pollock, S, French, WJ, Diamantis, S, Gimple, L, Neustel, M, Schwartz, S, Pereira, E, Spriggs, D, Strain, J, Vo, A, Chane, M, Hall, J, Vijay, N, Lotun, K, Lester, FM, Nahhas, A, Pope, T, Nager, P, Vohra, R, Bashir, R, Ahmed, H, Berlowitz, M, Fishberg, R, Barrucco, R, Yang, E, Radin, M, Sporn, D, Eisenberg, S, Landzberg, J, Mcgough, M, Turk, S, Schwartz, M, Sundram, PS, Jain, D, Zainea, M, Bayron, C, Karlsberg, R, Lui, H, Keen, W, Westerhausen, D, Khurana, S, Agarwal, H, Birchem, J, Penny, W, Chang, M, Murphy, S, Schifferdecker, B, Gilbert, JM, Chalavarya, G, Eaton, C, Schmedtje, JF, Christenson, S, Denham, D, Macdonell, A, Gibson, P, Rahman, A, Al Joundi, T, Conrad, G, Kotha, P, Love, M, Giesler, G, Rubenstein, H, Akright, L, Krawczyk, J, Wells, T, Welker, J, Foster, R, Gilmore, R, Anderson, J, Jacoby, D, Gardner, G, Dandillaya, R, Vora, K, Kostis, J, Hunter, J, Laxson, D, Ball, E, Camp, A, Lopes, R, Egydio, F, Kawakami, A, Oliveira, J, Wozniak, J, Matthews, A, Ratky, C, Valiris, J, Berdan, L, Hepditch, A, Quintero, K, Rorick, T, Westbrook, M, Pascual, A, Rovito, C, Bezault, M, Drouet, E, Simon, T, Alsweiler, C, Luyten, A, Aylward, P, Butters, J, Griffith, L, Shaw, M, Grunberg, L, Islam, S, Bougon, N, Faustino, D, Fontecave, S, Murphy, J, Verrier, M, Agnetti, V, Andersen, D, Badreddine, E, Bekkouche, M, Bouancheau, C, Brigui, I, Brocklehurst, M, Cianciarulo, J, Devaul, D, Domokos, S, Gache, C, Gobillot, C, Guillou, S, Healy, J, Heath, M, Jaiwal, G, Javierre, C, Labeirie, J, Monier, M, Morales, U, Mrabti, A, Mthombeni, B, Okan, B, Smith, L, Sheller, J, Sopena, S, Pellan, V, Benbernou, F, Bengrait, N, Lamoureux, M, Kralova, K, Scemama, M, Bejuit, R, Coulange, A, Berthou, C, Repincay, J, Lorenzato, C, Etienne, A, Gouet, V, Loizeau, V, Normand, M, Ourliac, A, Rondel, C, Adamo, A, Beltran, P, Barraud, P, Dubois-Gache, H, Halle, B, Metwally, L, Mourgues, M, Sotty, M, Vincendet, M, Cotruta, R, Zhu, C, Fournie-Lloret, D, Morrello, C, Perthuis, A, Picault, P, Zobouyan, I, ODYSSEY OUTCOMES Comm, İÜC, Ege Üniversitesi, Rushton-Smith, Sophie, and ODYSSEY OUTCOMES Committees and Investigators
- Subjects
Male ,Cardiac & Cardiovascular Systems ,MONOCLONAL-ANTIBODY ,alirocumab ,Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ,law.invention ,PCSK9 ,chemistry.chemical_compound ,Randomized controlled trial ,law ,Cardiac and Cardiovascular Systems ,1102 Cardiorespiratory Medicine and Haematology ,Hypercholesterolemia/blood ,Kardiologi ,Hazard ratio ,Middle Aged ,Treatment Outcome ,SAFETY ,Cardiology ,Female ,Drug Therapy, Combination ,Cholesterol, LDL/antagonists & inhibitors ,Cardiology and Cardiovascular Medicine ,Life Sciences & Biomedicine ,REDUCING LIPIDS ,Akutes Koronarsyndrom ,acute coronary syndrome ,cholesterol ,mortality ,PCSK9 protein ,Antibodies, Monoclonal, Humanized/administration & dosage ,medicine.medical_specialty ,Acute coronary syndrome ,Injections, Subcutaneous ,Hypercholesterolemia ,Placebo ,Antibodies, Monoclonal, Humanized ,1117 Public Health and Health Services ,Sterblichkeit ,Double-Blind Method ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,ddc:610 ,Alirocumab ,Aged ,Science & Technology ,Cholesterol ,business.industry ,EVOLOCUMAB ,1103 Clinical Sciences ,Cholesterol, LDL ,medicine.disease ,EFFICACY ,Increased risk ,chemistry ,Peripheral Vascular Disease ,Cardiovascular System & Hematology ,Cardiovascular System & Cardiology ,Acute Coronary Syndrome/blood ,Cholesterin ,Human medicine ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,business ,Follow-Up Studies - Abstract
bastos, jose/0000-0002-9526-3123; Manakshe, Gajendra/0000-0002-4983-4271; Tse, Hung Fat/0000-0002-9578-7808; Gislason, Gunnar H/0000-0002-0548-402X; Taskinen, Marja-Riitta/0000-0002-6229-3588; Racca, Vittorio/0000-0002-4465-3789; Keskin, Kudret/0000-0002-9049-1530; Sherwood, Matthew/0000-0002-4305-5883; Sandhu, Manjinder/0000-0003-2538-2079; Nikolaev, Konstantin/0000-0003-4601-6203; Ersanli, Murat/0000-0003-1847-3087; Raffel, Owen C/0000-0001-5470-7050; Abbate, Antonio/0000-0002-1930-785X; Muenzel, Thomas/0000-0001-5503-4150; Leonardi, Sergio/0000-0002-4800-6132; Chumakova, Galina A/0000-0002-2810-6531; Podoleanu, Cristian/0000-0001-9987-2519; Pereira, Helder/0000-0001-8656-4883; Reshetko, Olga/0000-0003-3107-7636, WOS: 000476768100007, PubMed: 31117810, Background: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. Methods: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) was a double-blind, randomized comparison of alirocumab or placebo in 18 924 patients who had an ACS 1 to 12 months previously and elevated atherogenic lipoproteins despite intensive statin therapy. Alirocumab dose was blindly titrated to target achieved low-density lipoprotein cholesterol (LDL-C) between 25 and 50 mg/dL. We examined the effects of treatment on all-cause death and its components, cardiovascular and noncardiovascular death, with log-rank testing. Joint semiparametric models tested associations between nonfatal cardiovascular events and cardiovascular or noncardiovascular death. Results: Median follow-up was 2.8 years. Death occurred in 334 (3.5%) and 392 (4.1%) patients, respectively, in the alirocumab and placebo groups (hazard ratio [HR], 0.85; 95% CI, 0.73 to 0.98; P=0.03, nominal P value). This resulted from nonsignificantly fewer cardiovascular (240 [2.5%] vs 271 [2.9%]; HR, 0.88; 95% CI, 0.74 to 1.05; P=0.15) and noncardiovascular (94 [1.0%] vs 121 [1.3%]; HR, 0.77; 95% CI, 0.59 to 1.01; P=0.06) deaths with alirocumab. in a prespecified analysis of 8242 patients eligible for >= 3 years follow-up, alirocumab reduced death (HR, 0.78; 95% CI, 0.65 to 0.94; P=0.01). Patients with nonfatal cardiovascular events were at increased risk for cardiovascular and noncardiovascular deaths (P= 100 mg/dL (2.59 mmol/L) had a greater absolute risk of death and a larger mortality benefit from alirocumab (HR, 0.71; 95% CI, 0.56 to 0.90; P-interaction=0.007). in the alirocumab group, all-cause death declined with achieved LDL-C at 4 months of treatment, to a level of approximately 30 mg/dL (adjusted P=0.017 for linear trend). Conclusions: Alirocumab added to intensive statin therapy has the potential to reduce death after acute coronary syndrome, particularly if treatment is maintained for >= 3 years, if baseline LDL-C is >= 100 mg/dL, or if achieved LDL-C is low., Sanofi; Regeneron Pharmaceuticals, Inc., The trial was funded by Sanofi and Regeneron Pharmaceuticals, Inc.
- Published
- 2019
28. Alirocumab Reduces Total Hospitalizations and Increases Days Alive and Out of Hospital in the ODYSSEY OUTCOMES Trial
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DiCenso, D, Gotcheva, N, Sourdille, T, White, HD, Schwartz, GG, Steg, PG, Bhatt, DL, Bittner, VA, Diaz, R, Harrington, RA, Jukema, JW, Szarek, M, Zeiher, AM, Tricoci, P, Mahaffey, KW, Edelberg, JM, Hanotin, C, Lecorps, G, Moryusef, A, Pordy, R, Sasiela, WJ, Drexel, H, Sinnaeve, P, Dilic, M, Gotcheva, NN, Goodman, SG, Prieto, JC, Yong, H, Lopez-Jaramillo, P, Pecin, I, Reiner, Z, Poulsen, SH, Viigimaa, M, Nieminen, MS, Danchin, N, Chumburidze, V, Tse, HF, Xavier, D, Zahger, D, Valgimigli, M, Kim, HS, Erglis, A, Laucevicius, A, Lopez, R, Lopez, GAR, Alings, M, Chua, T, Murin, J, Fras, Z, Dalby, AJ, Tunon, J, De Silva, HA, Chiang, CE, Sritara, P, Guneri, S, Parkhomenko, A, Ray, KK, Moriarty, PM, Roe, MT, Chaitman, B, Kelsey, SF, Olsson, AG, Rouleau, JL, Simoons, ML, Alexander, K, Meloni, C, Rosenson, R, Sijbrands, EJG, Alexander, JH, Armaganijan, L, Bagai, A, Bahit, MC, Brennan, JM, Clifton, S, DeVore, AD, Deloatch, S, Dickey, S, Dombrowski, K, Ducrocq, G, Eapen, Z, Endsley, P, Eppinger, A, Harrison, RW, Hess, CN, Hlatky, MA, Jordan, JD, Knowles, JW, Kolls, BJ, Kong, DF, Leonardi, S, Lillis, L, Maron, DJ, Marcus, J, Mathews, R, Mehta, RH, Mentz, RJ, Moreira, HG, Patel, CB, Pereira, SB, Perkins, L, Povsic, TJ, Puymirat, E, Jones, WS, Shah, BR, Sherwood, MW, Stringfellow, K, Sujjavanich, D, Toma, M, Van Diepen, SFP, Wilson, MD, Yan, ATK, Lopes, RD, Trotter, C, Schiavi, LB, Garrido, M, Alvarisqueta, AF, Sassone, SA, Bordonava, AP, De Lima, AEA, Schmidberg, JM, Duronto, EA, Caruso, OC, Novaretto, LP, Hominal, MA, Montana, OR, Caccavo, A, Vilamajo, OAG, Lorenzatti, AJ, Cartasegna, LR, Paterlini, GA, Mackinnon, IJ, Caime, GD, Amuchastegui, M, Salomone, R, Codutti, OR, Jure, HO, Bono, JOE, Hrabar, AD, Vallejos, JA, Guerrero, RAA, Novoa, F, Patocchi, CA, Zaidman, CJ, Giuliano, ME, Dran, RD, Vico, ML, Carnero, GS, Guzman, PN, Allende, JCM, Brasca, DFG, Labarta, MHB, Nani, S, Blumberg, EDS, Colombo, HR, Liberman, A, Luciardi, HL, Waisman, GD, Berli, MA, Duran, ROG, Cestari, HG, Luquez, HA, Giordano, JA, Saavedra, SS, Zapata, G, Costamagna, O, Llois, S, Waites, JH, Collins, N, Soward, A, Aylward, PE, Hii, CLS, Shaw, J, Arstall, MA, Horowitz, J, Rogers, JF, Colquhoun, D, Flores, REO, Roberts-Thomson, P, Raffel, O, Lehman, SJ, Aroney, C, Coverdale, SGM, Garrahy, PJ, Starmer, G, Sader, M, Carroll, PA, Dick, R, Zweiker, R, Hoppe, U, Huber, K, Berger, R, Weidinger, F, Faes, D, Hermans, K, Pirenne, B, Leone, A, Hoffer, E, Vrolix, MCM, De Wolf, L, Wollaert, B, Castadot, M, Dujardin, K, Beauloye, C, Vervoort, G, Striekwold, H, Convens, C, Roosen, J, Barbato, E, Claeys, M, Cools, F, Terzic, I, Barakovic, F, Midzic, Z, Pojskic, B, Fazlibegovic, E, Durak-Nalbantic, A, Vulic, D, Muslibegovic, A, Goronja, B, Reis, G, Sousa, L, Nicolau, JC, Giorgeto, FE, Silva, RP, Maia, LN, Rech, R, Rossi, PRF, Cerqueira, MJAG, Duda, N, Kalil, R, Kormann, A, Abrantes, JAM, Pimentel, P, Soggia, AP, de Santos, MON, Neuenschwander, F, Bodanese, LC, Michalaros, YL, Eliaschewitz, FG, Vidotti, MH, Leaes, PE, Botelho, RV, Kaiser, S, Manenti, ERFF, Precoma, DB, Jorge, JCM, Silva, PGMD, Silveira, JA, Saporito, W, Marin, JA, Feitosa, GS, Ritt, LEF, de Souza, JA, Costa, F, Souza, WKSB, Reis, HJL, Machado, L, Ayoub, JCA, Todorov, GV, Nikolov, FP, Velcheva, ES, Tzekova, ML, Benov, HO, Petranov, SL, Tumbev, HS, Shehova-Yankova, NS, Markov, DT, Raev, DH, Mollov, MN, Kichukov, KN, Ilieva-Pandeva, KA, Ivanova, R, Mincheva, VM, Lazov, PV, Dimov, BI, Senaratne, M, Stone, J, Kornder, J, Pearce, S, Dion, D, Savard, D, Pesant, Y, Pandey, A, Robinson, S, Gosselin, G, Vizel, S, Hoag, G, Bourgeois, R, Morisset, A, Sabbah, E, Sussex, B, Kouz, S, MacDonald, P, Diaz, A, Michaud, N, Fell, D, Leung, R, Vuurmans, T, Lai, C, Nigro, F, Davies, R, Nogareda, G, Vijayaraghavan, R, Ducas, J, Lepage, S, Mehta, S, Cha, J, Dupuis, R, Fong, P, Rodes-Cabau, J, Fadlallah, H, Cleveland, D, Huynh, T, Bata, I, Hameed, A, Pincetti, C, Potthoff, S, Acevedo, M, Aguirre, A, Vejar, M, Yanez, M, Araneda, G, Fernandez, M, Perez, L, Varleta, P, Florenzano, F, Huidobro, L, Raffo, CA, Olivares, C, Nahuelpan, L, Montecinos, H, Chen, JY, Dong, YG, Huang, WJ, Wang, JZ, Huang, SA, Yao, ZH, Li, X, Cui, L, Lin, WH, Sun, YM, Wang, JF, Li, JP, Zhang, XL, Zhu, H, Chen, D, Huang, L, Dong, SH, Su, GH, Xu, BA, Su, X, Cheng, XS, Lin, JX, Zong, WX, Li, HM, Feng, Y, Xu, DL, Yang, XC, Ke, YN, Lin, XF, Zhang, Z, Zheng, ZQ, Luo, ZR, Chen, YD, Ding, CH, Zheng, Y, Li, XD, Peng, DQ, Li, Y, Wei, M, Liu, SW, Yu, YH, Qu, BM, Jiang, WH, Zhou, YJ, Zhao, XS, Yuan, ZY, Guo, Y, Xu, XP, Shi, XB, Ge, JB, Fu, GS, Bai, F, Fang, WY, Shou, XL, Yang, XJ, Wang, JA, Sun, YX, Lu, QH, Zhang, RY, Zhu, JH, Xu, YZ, Fan, ZC, Li, TC, Wu, C, Jaramillo, N, Vallejo, GS, Botia, DCL, Lopez, RB, De Salazar, DIM, Bonfanti, AJC, Higuera, JD, Silva, SIB, Lozada, HJG, Arroyo, JAC, Mendoza, JLA, Ruiz, RLF, Jatin, FGM, Herazo, AS, Parada, JC, Triana, MAU, Strozzi, M, Car, S, Milicic, D, Bencic, ML, Pintaric, H, Prvulovic, D, Sikic, J, Persic, V, Mileta, D, Stambuk, K, Zdravko, B, Tomulic, V, Krstulovic, SM, Starcevic, B, Spinar, J, Horak, D, Stasek, J, Alan, D, Machova, V, Linhart, A, Novotny, V, Kaucak, V, Rokyta, R, Naplava, R, Coufal, Z, Adamkova, V, Podpera, I, Zizka, J, Motovska, Z, Marusincova, I, Svab, P, Ostadal, P, Heinc, P, Kuchar, J, Povolny, P, Matuska, J, Raungaard, B, Clemmensen, P, Bang, LE, May, O, Bottcher, M, Hove, JD, Frost, L, Gislason, G, Larsen, J, Johansen, PB, Hald, F, Jeppesen, J, Nielsen, T, Kristensen, KS, Walichiewicz, PM, Lomholdt, JD, Klausen, IC, Nielsen, PK, Davidsen, F, Videbaek, L, Soots, M, Vahula, V, Hedman, A, Soopold, U, Martsin, K, Kristjan, A, Taskinen, MR, Porthan, K, Airaksinen, JK, Juonala, M, Kiviniemi, T, Vikman, S, Posio, P, Taurio, J, Huikuri, H, Kaikkonen, K, Coste, P, Ferrari, E, Morel, O, Montalescot, G, Barone-Rochette, G, Mansourati, J, Cottin, Y, Leclercq, F, Belhassane, A, Delarche, N, Boccara, F, Paganelli, F, Clerc, J, Schiele, F, Aboyans, V, Probst, V, Berland, J, Lefevre, T, Citron, B, Khintibidze, I, Shaburishvili, T, Pagava, Z, Ghlonti, R, Lominadze, Z, Khabeishvili, G, Hemetsberger, R, Rauch-Krohnert, U, Stratmann, M, Appel, KF, Schmidt, E, Omran, H, Stellbrink, C, Dorsel, T, Lianopoulos, E, Marx, R, Zirlik, A, Schellenberg, D, Heitzer, T, Laufs, U, Marx, N, Gielen, S, Winkelmann, B, Behrens, S, Sydow, K, Simonis, G, Muenzel, T, Werner, N, Leggewie, S, Bocker, D, Braun-Dullaeus, R, Toursarkissian, N, Jeserich, M, Weissbrodt, M, Schaeufele, T, Weil, J, Voller, H, Waltenberger, J, Natour, M, Schmitt, S, Steiner, S, Heidenreich, L, Gremmler, U, Killat, H, Rieker, W, Patsilinakos, S, Kartalis, A, Manolis, A, Sionis, D, Liberopoulos, E, Skoumas, I, Athyros, V, Vardas, P, Parthenakis, F, Alexopoulos, D, Hahalis, G, Lekakis, J, Hatzitolios, A, Ovando, SRF, Valdovinos, PCM, Benecke, JLA, De Leon, ERR, Yan, BPY, Siu, DCW, Turi, T, Merkely, B, Kiss, RG, Ungi, I, Lupkovics, G, Nagy, L, Katona, A, Edes, I, Muller, G, Horvath, I, Kapin, T, Falukozy, J, Kumbla, M, Sandhu, M, Annam, S, Proddutur, NR, Premchand, RK, Mahajan, A, Abhyanakar, AD, Kerkar, P, Govinda, RA, Oomman, A, Sinha, D, Patil, SN, Kahali, D, Sawhney, J, Joshi, AB, Chaudhary, S, Harkut, P, Guha, S, Porwal, S, Jujjuru, S, Pothineni, RB, Monteiro, MR, Khan, A, Iyengar, SS, Grewal, JS, Chopda, M, Fulwani, MC, Patange, A, Chopra, VK, Goyal, NK, Shinde, R, Manakshe, GV, Patki, N, Sethi, S, Munusamy, V, Karna, S, Adhyapak, S, Pandurangi, U, Mathur, R, Kalashetti, S, Bhagwat, A, Raghuraman, B, Yerra, SK, Bhansali, P, Borse, R, Das, S, Abdullakutty, J, Saathe, S, Abdullkutty, J, Sathe, S, Palimkar, P, Atar, S, Shechter, M, Mosseri, M, Arbel, Y, Lotan, C, Rosenschein, U, Katz, A, Henkin, Y, Francis, A, Klutstein, M, Nikolsky, E, Turgeman, Y, Halabi, M, Kornowski, R, Jonas, M, Amir, O, Rozenman, Y, Fuchs, S, Hussein, O, Gavish, D, Vered, Z, Caraco, Y, Elias, M, Tov, N, Lishner, M, Elias, N, Piovaccari, G, De Pellegrin, A, Guardigli, G, Licciardello, G, Auguadro, C, Cuccia, C, Salvioni, A, Musumeci, G, Calabro, P, Novo, S, Faggiano, P, De Cesare, NB, Berti, S, Cavallini, C, Puccioni, E, Galvani, M, Tespili, M, Piatti, P, Palvarini, M, De Luca, G, Violini, R, De Leo, A, Filardi, PP, Ferratini, M, Ricca, V, Dai, K, Kamiya, H, Ando, K, Takeda, Y, Morino, Y, Hata, Y, Kimura, K, Kishi, K, Michishita, I, Uehara, H, Higashikata, T, Hirayama, A, Hirooka, K, Sakagami, S, Taguchi, S, Koike, A, Fujinaga, H, Koba, S, Kozuma, K, Kawasaki, T, Ono, Y, Shimizu, M, Katsuda, Y, Wada, A, Shinke, T, Kimura, T, Ako, J, Fujii, K, Takahashi, T, Sakamoto, T, Furukawa, Y, Sugino, H, Mano, T, Utsu, N, Ito, K, Haraguchi, T, Ueda, Y, Nishibe, A, Masutani, M, Fujimoto, K, Yoon, JH, Kim, SH, Park, HS, Chae, IH, Kim, MH, Jeong, MH, Rha, S, Kim, C, Hong, T, Tahk, SJ, Kim, Y, Busmane, A, Pontaga, N, Strelnieks, A, Mintale, I, Sime, I, Petrulioniene, Z, Kavaliauskiene, R, Jurgaitiene, R, Sakalyte, G, Slapikas, R, Norkiene, S, Misonis, N, Kibarskis, A, Kubilius, R, Bojovski, S, Kedev, S, Lozance, N, Kjovkaroski, A, Doncovska, S, Ong, TK, Kasim, S, Maskon, O, Kandasamy, B, Yusoff, K, Liew, HB, Mohamed, WMIW, Castillo, AG, Calvillo, JC, Campos, PF, Fragoso, JCN, Llamas, EAB, Gamba, MAA, Madrigal, JC, Salas, LGG, Rosas, EL, Diaz, BG, Vazquez, ES, Ackar, AN, Esperon, GAL, Sanchez, CRM, De Leon, MG, Otero, RS, Salmon, GF, Rios, JA, Ruiz, JAG, Breedveld, RW, Hoogslag, PAM, Suryapranata, H, Oomen, A, Wiersma, JJ, Van Der Wal, RMA, Van Huysduynen-Monraats, PSH, Karalis, I, Verdel, GJE, Brueren, BR, Troquay, RPT, Viergever, EP, Al-Windy, NYY, Bartels, GL, Cornel, JH, Hermans, WRM, Herrman, JPR, Bos, RJ, Groutars, RGEJ, Van Der Zwaan, CC, Kaplan, R, Ronner, E, Groenemeijer, BE, Bronzwaer, PNA, Liem, AAH, Rensing, BJWM, Bokern, MJJA, Nijmeijer, R, Hersbach, FMRJ, Willems, FF, Gosselink, ATM, Elliott, J, Wilkins, G, Fisher, R, Scott, D, Hart, H, Stewart, R, Harding, S, Ternouth, I, Fisher, N, Aitken, D, Anscombe, R, Davidson, L, Tomala, T, Nygard, O, Sparby, JA, Andersen, K, Gullestad, L, Jortveit, J, Munk, PS, Singsaas, EG, Halvorsen, S, Hurtig, U, Flores, RMC, Ticona, JRC, Velasquez, JRD, Miguel, SAN, Perez, ESS, Chambilla, JMC, Ayala, CAC, Leon, RPC, Gonzales, RJV, Zuniga, JDH, Cosavalente, LAC, Mannucci, JEB, Landeo, JH, Navarro, NCL, Concha, YMR, Chavez, VER, Hernandez, HAA, Nunez, CAZ, Ramos, WM, Ferrolino, A, Sy, RAG, Tirador, L, Sy, RG, Matiga, G, Coching, RM, Bernan, A, Rogelio, G, Morales, DD, Tan, E, Sulit, DJ, Wlodarczak, A, Jaworska, K, Skonieczny, G, Pawlowicz, L, Wojewod, P, Busz-Papiez, B, Bednarski, J, Goch, A, Staneta, P, Dulak, E, Budaj, A, Saminsk, K, Krasowski, W, Sudnik, W, Zurakowski, A, Skorski, M, Lysek, R, Miklaszewicz, B, Kubica, J, Lipko, JA, Kostarska-Srokosz, E, Piepiorka, M, Drzewiecka, A, Sciborski, R, Stasiewski, A, Blicharski, T, Bystryk, L, Szpajer, M, Korol, M, Czerski, T, Mirek-Bryniarska, E, Gniot, J, Lubinski, A, Gorny, J, Franek, E, Raczak, G, Szwed, H, Monteiro, P, Bastos, JM, Pereira, HH, Martins, D, Morais, J, Seixo, F, Mendonca, C, Botelho, A, Minescu, B, Istratoaie, O, Tesloianu, DN, Dorobantu, M, Cristian, G, Podoleanu, CGC, Constantinescu, MCA, Bengus, CM, Militaru, C, Rosu, D, Parepa, IR, Matei, AV, Alexandru, TM, Coman, I, Cioranu, RS, Dimulescu, D, Shvarts, Y, Orlikova, O, Kobalava, Z, Barbarash, OL, Markov, V, Lyamina, N, Gordienko, A, Zrazhevsky, K, Vishnevsky, AY, Gurevich, V, Stryuk, R, Lomakin, NV, Bokarev, I, Shalaev, S, Khaisheva, L, Chizhov, P, Viktorova, I, Osokina, N, Akatova, E, Chumakova, G, Libov, I, Voevoda, MI, Tretyakova, TV, Baranov, E, Shustov, S, Yakushin, S, Gordeev, I, Khasanov, N, Reshetko, O, Sotnikova, T, Molchanova, O, Nikolaev, K, Gapon, L, Baranova, E, Shogenov, Z, Kosmachova, E, Karpov, Y, Povzun, A, Egorova, L, Tyrenko, VV, Ivanov, IG, Kanorsky, S, Simic, D, Ivanovic, N, Davidovic, G, Tasic, N, Asanin, MR, Stojic, S, Apostolovic, SR, Ilic, S, Putnikovic, B, Stankovic, A, Arandjelovic, A, Radovanovic, S, Ristic, AD, Balinovac, J, Dincic, DV, Seferovic, P, Dodic, S, Dimkovic, S, Poh, KK, Ong, HY, Micko, K, Nociar, J, Pella, D, Fulop, P, Hranai, M, Palka, J, Mazur, J, Majercak, I, Dzupina, A, Fazekas, F, Gonsorcik, J, Bugan, V, Selecky, J, Kamensky, G, Strbova, J, Smik, R, Dukat, A, Olexa, P, Zuran, I, Poklukar, J, Suligoj, NC, Cevc, M, Cyster, HP, Ranjith, N, Corbett, C, Bayat, J, Makotoko, EM, Kapp, IE, Basson, MMD, Lottering, H, Van Zyl, LJ, Sebastian, PJ, Pillay, T, Saaiman, JA, Commerford, PJ, Cassimjee, S, Ebrahim, IO, Sarvan, M, Mynhardt, JH, Reuter, H, Moodley, R, Vida, M, Fillat, ARC, Peris, VB, Jimenez, FF, Marin, F, Fernandez, JMC, Gil-Extremera, B, Diz, FW, Garcia-Dorado, D, Iniguez, A, Fernandez, JT, Gonzalez-Juanatey, JR, Portales, JF, Murillo, FC, Pericas, LM, Zamorano, JL, Martin, MD, Cortada, JB, Martin, JJA, Fernandez, JRD, Fernandez, JFD, Lledo, JAG, Sales, JC, Rodriguez, JB, Tragant, GG, Benedicto, A, Gonzalez-Juanatey, C, Potau, MC, Perez, IP, De La Tassa, CM, Rincon, PLO, Recena, JB, Escudier, JM, Payeras, AC, Orcajo, NA, Valdivielso, P, Constantine, G, Haniffa, R, Tissera, N, Amarasekera, S, Fernando, N, Jayawardena, J, Santharaj, W, Ekanayaka, R, Mendis, S, Senaratne, V, Mayurathan, G, Sirisena, T, Rajapaksha, A, Herath, JI, Amarasena, N, Berglund, S, Rasmanis, G, Witt, N, Mourtzinis, G, Nicol, P, Hansen, O, Romeo, S, Jensen, SA, Torstensson, I, Ahremark, U, Sundelin, T, Moccetti, T, Muller, C, Mach, F, Binder, R, Tsai, WC, Ueng, KC, Lai, WT, Liu, ME, Hwang, JJ, Yin, WH, Hsieh, IC, Kuo, JY, Huang, TY, Fang, CY, Kaewsuwanna, P, Soonfuang, W, Jintapakorn, W, Sukonthasarn, A, Wongpraparut, N, Sastravaha, K, Sansanayudh, N, Kehasukcharoen, W, Piyayotai, D, Chotnoparatpat, P, Camsari, A, Kultursay, H, Mutlu, B, Ersanli, M, Demirtas, M, Kirma, C, Ural, E, Koldas, L, Karpenko, O, Prokhorov, A, Vakaluyk, I, Myshanych, H, Reshotko, D, Batushkin, V, Rudenko, L, Kovalskyi, I, Kushnir, M, Tseluyko, V, Mostovoy, Y, Stanislavchuk, M, Kyiak, Y, Karpenko, Y, Malynovsky, Y, Klantsa, A, Kutniy, O, Amosova, E, Tashchuk, V, Leshchuk, O, Rishko, M, Kopytsya, M, Yagensky, A, Vatutin, M, Bagriy, A, Barna, OM, Ushakov, O, Dzyak, G, Goloborodko, B, Rudenko, A, Zheleznyy, V, Trevelyan, J, Zaman, A, Lee, K, Moriarty, A, Aggarwal, RK, Clifford, P, Wong, YK, Iqbal, SM, Subkovas, E, Braganza, D, Sarkar, D, Storey, R, Griffiths, H, Mcclure, S, Muthusamy, R, Kurian, J, Levy, T, Barr, C, Kadr, H, Gerber, R, Simaitis, A, Soran, H, Mathur, A, Brodison, A, Oliver, R, Mudawi, T, Reynolds, T, Sharman, D, Butler, R, Wilkinson, P, Lip, GYH, Halcox, J, Vardi, G, Baldari, D, Brabham, D, Treasure, C, Dahl, C, Palmer, B, Wiseman, A, Puri, S, Mohart, AE, Ince, C, Flores, E, Wright, S, Cheng, SC, Rosenberg, M, Rogers, W, Kosinski, E, Forgosh, L, Waltman, J, Khan, M, Shoukfeh, M, Dagher, G, Lieber, I, Kumar, P, East, C, Krichmar, P, White, L, Knickelbine, T, Haldis, T, Gillespie, E, Suh, D, Arif, I, Akhter, F, Carlson, E, D'Urso, M, El-Ahdab, F, Nelson, W, Harris, B, Cohen, S, Carter, L, Sabatino, K, Haddad, T, Malik, A, Rao, S, Mulkay, A, Jovin, I, Klancke, K, Malhotra, V, Devarapalli, SK, Koren, M, Chandna, H, Dodds, G, Janik, M, Moran, J, Sumner, A, Kobayashi, J, Davis, W, Yazdani, S, Pasquini, J, Thakkar, M, Vedere, A, Leimbach, W, Rider, J, Singh, N, Shah, AV, Janosik, D, Pepine, C, Berman, B, Gelormini, J, Daniels, C, Keating, F, Kondo, NI, Shetty, S, Waider, W, Takata, T, Abu-Fadel, M, Shah, V, Aggarwal, R, Izzo, M, Kumar, A, Hattler, B, Link, C, Bortnick, A, Kinzfogl, G, Ghitis, A, Larry, J, Teufel, E, Kuhlman, P, Mclaurin, B, Zhang, WW, Thew, S, Abbas, J, White, M, Ranadive, N, Gring, C, Henderson, D, Schuchard, T, Farhat, N, Kline, G, Mahal, S, Whitaker, J, Speirs, S, Andersen, R, Daboul, N, Horwitz, P, Ponce, G, Jafar, Z, Mcgarvey, J, Panchal, V, Voyce, S, Blok, T, Sheldon, W, Azizad, MM, Schmalfuss, C, Picone, M, Herzog, W, Lindsey, J, Nowins, R, Lepor, N, El Shahawy, M, Weintraub, H, Irimpen, A, May, W, Galski, T, Chu, A, Mody, F, Hodes, Z, Rose, G, Fairlamb, J, Lambert, C, Raisinghani, A, Abbate, A, King, M, Carey, C, Gerber, J, Younis, L, Park, H, Vidovich, M, Knutson, T, Friedman, D, Chaleff, F, Loussararian, A, Rozeman, P, Kimmelstiel, C, Silver, K, Foster, M, Tonnessen, G, Amlani, M, Wali, A, Malozzi, C, Wattanakit, K, O'Donnell, PJ, Singal, D, Jaffrani, N, Banuru, S, Fisher, D, Xenakis, M, Perlmutter, N, Bhagwat, R, Strader, J, Akyea-Djamson, A, Labroo, A, Marais, HJ, Claxton, E, Berk, M, Rossi, P, Joshi, P, Khaira, AS, Kumkumian, G, Lupovitch, S, Purow, J, Welka, S, Hoffman, D, Fischer, S, Soroka, E, Eagerton, D, Pancholy, S, Ray, M, Farrar, M, Pollock, S, French, WJ, Diamantis, S, Gimple, L, Neustel, M, Schwartz, S, Pereira, E, Spriggs, D, Strain, J, Vo, A, Chane, M, Hall, J, Vijay, N, Lotun, K, Lester, FM, Nahhas, A, Pope, T, Nager, P, Vohra, R, Bashir, R, Ahmed, H, Berlowitz, M, Fishberg, R, Barrucco, R, Yang, E, Radin, M, Sporn, D, Eisenberg, S, Landzberg, J, Mcgough, M, Turk, S, Schwartz, M, Sundram, PS, Jain, D, Zainea, M, Bayron, C, Karlsberg, R, Lui, H, Keen, W, Westerhausen, D, Khurana, S, Agarwal, H, Birchem, J, Penny, W, Chang, M, Murphy, S, Schifferdecker, B, Gilbert, JM, Chalavarya, G, Eaton, C, Schmedtje, JF, Christenson, S, Denham, D, Macdonell, A, Gibson, P, Rahman, A, Al Joundi, T, Conrad, G, Kotha, P, Love, M, Giesler, G, Rubenstein, H, Akright, L, Krawczyk, J, Wells, T, Welker, J, Foster, R, Gilmore, R, Anderson, J, Jacoby, D, Gardner, G, Dandillaya, R, Vora, K, Kostis, J, Hunter, J, Laxson, D, Ball, E, Camp, A, Lopes, R, Egydio, F, Kawakami, A, Oliveira, J, Wozniak, J, Matthews, A, Ratky, C, Valiris, J, Berdan, L, Hepditch, A, Quintero, K, Rorick, T, Westbrook, M, Pascual, A, Rovito, C, Bezault, M, Drouet, E, Simon, T, Alsweiler, C, Luyten, A, Aylward, P, Butters, J, Griffith, L, Shaw, M, Hagstrom, E, Grunberg, L, Islam, S, Bregeault, MF, Bougon, N, Faustino, D, Fontecave, S, Murphy, J, Tamby, JF, Verrier, M, Agnetti, V, Andersen, D, Badreddine, E, Bekkouche, M, Bouancheau, C, Brigui, I, Brocklehurst, M, Cianciarulo, J, Devaul, D, Domokos, S, Gache, C, Gobillot, C, Guillou, S, Healy, J, Heath, M, Jaiwal, G, Javierre, C, Labeirie, J, Monier, M, Morales, U, Mrabti, A, Mthombeni, B, Okan, B, Smith, L, Sheller, J, Sopena, S, Pellan, V, Benbernou, F, Bengrait, N, Lamoureux, M, Kralova, K, Scemama, M, Bejuit, R, Coulange, A, Berthou, C, Repincay, J, Lorenzato, C, Etienne, A, Gouet, V, Loizeau, V, Normand, M, Ourliac, A, Rondel, C, Adamo, A, Beltran, P, Barraud, P, Dubois-Gache, H, Halle, B, Metwally, L, Mourgues, M, Sotty, M, Vincendet, M, Cotruta, R, Zhu, CY, Fournie-Lloret, D, Morrello, C, Perthuis, A, Picault, P, Zobouyan, I, ODYSSEY OUTCOMES Comm Inve, Ege Üniversitesi, Cardiology, and Internal Medicine
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medicine.medical_specialty ,Acute coronary syndrome ,Time Factors ,acute coronary syndrome ,alirocumab ,global burden of disease ,hospitalization ,myocardial infarction ,PCSK9 ,030204 cardiovascular system & hematology ,Antibodies, Monoclonal, Humanized ,Placebo ,Patient Readmission ,Risk Assessment ,03 medical and health sciences ,Patient Admission ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Humans ,Angina, Unstable ,Hospital Mortality ,030212 general & internal medicine ,Myocardial infarction ,03.02. Klinikai orvostan ,Dyslipidemias ,Alirocumab ,Out of hospital ,business.industry ,Anticholesteremic Agents ,Cholesterol, HDL ,Cholesterol hdl ,Cholesterol, LDL ,medicine.disease ,Treatment Outcome ,Drug Therapy, Combination ,Human medicine ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Cardiology and Cardiovascular Medicine ,business ,Cardiovascular outcomes ,Biomarkers - Abstract
Sherwood, Matthew/0000-0002-4305-5883; Abbate, Antonio/0000-0002-1930-785X; Moris, Cesar/0000-0002-2871-190X; Ersanli, Murat/0000-0003-1847-3087; Taskinen, Marja-Riitta/0000-0002-6229-3588; bastos, jose/0000-0002-9526-3123; Reshetko, Olga/0000-0003-3107-7636; Nikolaev, Konstantin/0000-0003-4601-6203; Leonardi, Sergio/0000-0002-4800-6132; Raffel, Owen C/0000-0001-5470-7050; Racca, Vittorio/0000-0002-4465-3789; Podoleanu, Cristian/0000-0001-9987-2519; Gislason, Gunnar H/0000-0002-0548-402X; Muenzel, Thomas/0000-0001-5503-4150; Tse, Hung Fat/0000-0002-9578-7808; Chumakova, Galina A/0000-0002-2810-6531, WOS: 000502609000004, PubMed: 31707826, Background: in ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab), alirocumab was compared with placebo, added to high-intensity or maximum tolerated statin treatment after acute coronary syndrome in 18924 patients. Alirocumab reduced first occurrence of the primary composite end point-coronary heart disease death, nonfatal myocardial infarction, fatal or nonfatal ischemic stroke, or hospitalization for unstable angina-as well as total nonfatal cardiovascular events and all-cause deaths. the present analysis determined whether alirocumab reduced total (first and subsequent) hospitalizations and death and increased days alive and out of hospital (DAOH) and percent DAOH in ODYSSEY OUTCOMES. Methods and Results: in prespecified analyses, hazard functions for total hospitalizations and death were jointly estimated by a semiparametric model, while in post hoc analyses, DAOH and percent DAOH were compared between treatment groups with Poisson regression and one-inflated beta regression, respectively. With 16629 total hospitalizations and 726 deaths, 331 fewer hospitalizations, and 58 fewer deaths were observed with alirocumab compared with placebo, translating to 15.6 total hospitalizations or deaths avoided with alirocumab per 1000 patient-years of assigned treatment. Alirocumab reduced total hospitalizations (hazard ratio, 0.96 [95% CI, 0.92-1.00]; P=0.04) and increased DAOH relative to placebo (rate ratio, 1.003 [95% CI, 1.000-1.007]; P=0.05), primarily through a reduction in days dead (rate ratio, 0.847 [95% CI, 0.728-0.986]; P=0.03). Patients randomized to alirocumab were also more likely to survive to the end of the study without hospitalization (odds ratio, 1.06 [95% CI, 1.00-1.13]; P=0.03). Conclusions: Alirocumab reduced total hospitalizations with corresponding small increases in DAOH and percent DAOH. These outcomes provide alternative patient-centered metrics to capture the totality of alirocumab clinical efficacy after acute coronary syndrome. Clinical Trial Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01663402., Fondation Assistance Publique-Hopitaux de Paris, Paris, France, We thank the patients, study coordinators, and investigators who participated in this trial. Sophie Rushton-Smith, PhD (MedLink Healthcare Communications, London) provided editorial assistance in the preparation of the article (limited to editing for style, referencing, and figure and table editing) and was funded by Fondation Assistance Publique-Hopitaux de Paris, Paris, France.
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29. Acute myocardial infarction in young patients: the culprit is not always a ruptured atherosclerotic plaque
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Siotia, A. K., Gunn, J., Muthusamy, R., and Campbell, S.
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30. Thoracoscopic resection of esophageal duplication cysts
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Herbella, F. A. M., Tedesco, P., Muthusamy, R., and Patti, M. G.
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- 2006
31. Easy yet so easily missed
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Siotia, A K and Muthusamy, R
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- 2005
32. Postoperative hypoxia in a woman with Down's syndrome: case outcome
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Siotia, A K, Chaudhuri, A, Muzulu, S I, Harling, D, and Muthusamy, R
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- 2005
33. Postoperative hypoxia in a woman with Down's syndrome: case progression
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Siotia, A K, Chaudhuri, A, Muzulu, S I, Harling, D, and Muthusamy, R
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- 2005
34. Active inflammatory bowel disease and coronary artery dissection
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Srinivas, M, Basumani, P, Muthusamy, R, and Wheeldon, N
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- 2005
35. Mitral valve repair in a developing country
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Balasundaram, S., Gometza, B., Muthusamy, R., and Duran, C. M. G.
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- 1992
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36. Assessment of depression following acute myocardial infarction using the Beck depression inventory
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Steeds, R P, Bickerton, D, Smith, M J, and Muthusamy, R
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- 2004
37. Abnormal ventricular conduction following dothiepin overdose simulating acute myocardial infarction
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STEEDS, R P and MUTHUSAMY, R
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- 2000
38. Enhanced GMD Technique for Segmentation of Yarn Images based on Parametric Value and Intensity Gradient Analysis
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Muthusamy, R. Sudha, primary and Chitraa, V., additional
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39. Dysplasia severity is associated with poor quality of life in patients with Barrett's esophagus referred for endoscopic eradication therapy
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Han, S, primary, Yadlapati, R, additional, Simon, V, additional, Ezekwe, E, additional, Early, D S, additional, Kushnir, V, additional, Hollander, T, additional, Brauer, B C, additional, Hammad, H, additional, Edmundowicz, S A, additional, Wood, M, additional, Shaheen, N J, additional, Muthusamy, R V, additional, Komanduri, S, additional, and Wani, S, additional
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- 2018
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40. Platelet inhibition with ticagrelor 60 mg versus 90 mg twice daily in the PEGASUS-TIMI 54 trial
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Storey, R.F., Angiolillo, D.J., Bonaca, M.P., Thomas, M.R., Judge, H.M., Rollini, F., Franchi, F., Ahsan, A.J., Bhatt, D.L., Kuder, J.F., Steg, P.G., Cohen, M., Muthusamy, R., Braunwald, E., and Sabatine, M.S.
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Background\ud \ud The PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients with Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin–Thrombolysis In Myocardial Infarction 54) trial studied 2 doses of ticagrelor, 90 mg twice a day (bid) and 60 mg bid, for long-term prevention of ischemic events in patients with prior myocardial infarction. Both doses similarly reduced the rate of ischemic events versus placebo. The pharmacokinetics and pharmacodynamics of ticagrelor 60 mg bid have not been studied.\ud \ud \ud \ud Objectives\ud \ud In this study, the authors sought to study the pharmacokinetics and pharmacodynamics for ticagrelor 60 mg compared with 90 mg bid.\ud \ud \ud \ud Methods\ud \ud A total of 180 patients who received >4 weeks of study medication had blood sampling in the morning pre-maintenance dose and again 2 h post-dose. All patients received aspirin. Plasma levels of ticagrelor and its active metabolite AR-C124910XX were determined. P2Y12 inhibition was assessed by the VerifyNow P2Y12 assay (Accumetrics, Inc., San Diego, California) (P2Y12 reaction units [PRU]), light transmittance aggregometry (adenosine diphosphate 5 and 20 μmol/l and arachidonic acid), and vasodilator-stimulated phosphoprotein phosphorylation assays. VerifyNow Aspirin assays and serum thromboxane B2 measurements were performed.\ud \ud \ud \ud Results\ud \ud Mean pre- and post-dose plasma levels of ticagrelor were 35% and 38% lower, respectively, with 60 mg versus 90 mg. Both doses achieved high levels of platelet inhibition pre- and post-dose, with numerically slightly more variability with 60 mg: mean (SD) pre-dose PRU values were 59 ± 63 and 47 ± 43 for ticagrelor 60 and 90 mg, respectively (p = 0.34). High platelet reactivity, determined as PRU >208, was rare with the 60-mg pre-dose and was absent post-dose. Platelet reactivity pre- and post-dose, as measured by light transmittance aggregometry or vasodilator-stimulated phosphoprotein assays, was numerically but not significantly lower with 90 mg than with 60 mg. Aspirin response was not affected by either dose.\ud \ud \ud \ud Conclusions\ud \ud Ticagrelor 60 mg bid achieved high levels of peak and trough platelet inhibition in nearly all patients, similar to that with 90 mg bid, helping to explain the efficacy of the lower ticagrelor dose in PEGASUS-TIMI 54.
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- 2016
41. Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction
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Bonaca, MP, Bhatt, DL, Cohen, M, Steg, PG, Storey, RF, Jensen, EC, Magnani, G, Bansilal, S, Fish, MP, Im, K, Bengtsson, O, Ophuis, TO, Budaj, A, Theroux, P, Ruda, M, Hamm, C, Goto, S, Spinar, J, Nicolau, JC, Kiss, RG, Murphy, SA, Wiviott, SD, Held, P, Braunwald, E, Sabatine, MS, Morin, S, Dantzer, E, Acquilano, D, McGuire, RL, Gannon, JB, Gershman, E, Ahlbom, AM, Boberg, B, Abola, MT, Ardissino, D, Aylward, P, Corbalan, R, Dalby, A, Diaz, R, Hu, DY, Isaza, D, Kamensky, G, Kiss, R, Kontny, F, Lopez-Sendon, J, Medina, F, Montalescot, G, Nicolau, J, Paolasso, E, Parkhomenko, A, Van De Werf, F, Anderson, JL, White, HD, Verheugt, FWA, Pedersen, TR, DeMets, DL, Lowe, C, Arevalo, C, Awtry, E, Berger, C, Croce, K, Desai, A, Gelfand, E, Ho, C, Leeman, D, Link, M, Norden, A, Pande, A, Rost, N, Ruberg, F, Silverman, S, Singhal, A, Vita, J, Alvarisqueta, A, De Gennaro, N, Berli, M, Roude, AE, Di Gennaro, JA, Albisu, JF, Caccavo, A, Torres, M, Cuadrado, J, Bordoni, P, Cuello, J, Aviles, A, Glenny, A, Recoaro, R, Fernandez, R, Strada, BN, Fuentealba, V, Gallo, C, Duran, RG, Garcia, C, Hominal, M, Castoldi, M, Jure, H, Pacora, FF, Lorenzatti, A, Martinez, JM, Macin, S, Cocco, N, MacKinnon, I, Bagnato, MB, Marino, J, Cusimano, S, Arias, V, Focaccia, M, Muntaner, J, Mansilla, V, Poy, C, Prado, A, Paterlini, G, Montana, O, Camino, A, Sala, J, Luciani, C, Vico, M, Morell, Y, Dumont, C, Vottero, E, Zangroniz, P, Lescano, A, Morara, P, Marquez, LL, Patron, FR, Labarta, GB, Sivila, CD, Quiroga, AR, Maffei, L, Sassone, S, Rolandi, F, Vesentini, N, Carnero, G, Del Verme, S, Hershson, A, Figal, JC, Viso, ME, Hii, C, Smith, K, Singh, B, Acampo, M, Rogers, J, ODonoghue, M, Amerena, J, Long, A, Dart, A, Kay, S, Worthley, M, Nimmo, J, Lehman, R, Morrison, H, Dick, R, Savage, C, van Gaal, W, Park, M, Blombery, P, McCarthy, C, Oqueli, E, Hill, D, Sader, M, Vrachas, D, Purnell, P, Vibert, J, Collins, N, Gordon, A, Arstall, M, Rose, J, Aroney, C, Cleave, P, Fitzpatrick, M, Mackenzie, M, Garrahy, P, Hall, C, Nelson, G, Reid, E, Lee, A, Gibbs, J, Thompson, P, Crittenden, J, Hammett, C, Hindom, L, Antonis, P, Manzoney, A, Cross, D, Pollard, C, Brieger, D, Wu, J, Whelan, A, Tulloch, G, Taylor, A, Smith, B, Horowitz, J, Black, M, Boland, J, Malmendier, D, Celen, H, Wendelen, E, Claeys, M, Pieter, M, Cools, F, Simons, N, De Maeseneire, S, De Wolf, L, Brike, C, Dubois, P, Bolado, ACY, Foading-Deffo, B, Tahon, S, Friart, A, Arend, C, Gevaert, S, Verdegem, P, Marechal, P, Gits, F, Pierard, L, Celentano, C, Pirenne, B, Bouvy, C, Renkin, J, Huyberechts, D, Sinnaeve, P, De Velder, L, Stammen, F, Casier, T, Striekwold, H, Van den Broeck, D, Thoeng, J, Goris, R, Timmermans, P, Collard, SJ, Van De Borne, P, De Clippel, M, Wollaert, B, Jacobs, C, Vankelecom, B, Daelemans, Y, Vervoort, G, Drieghe, S, Vranckx, P, Janssen, A, Vrolix, M, Simenon, I, Wijns, W, Delacroix, H, Denie, D, Schoors, D, Lemoine, I, Cornelis, K, Willems, AM, Schroder, E, Domange, J, Greque, G, Machado, H, Armaganijan, D, Del Monaco, MI, da Silva, D, Nakazone, R, Dutra, O, Vaz, R, Daher, R, Rodrigues, D, Guimaraes, A, Teixeira, A, Saraiva, J, Leaes, P, Blacher, M, Maia, L, Nakazone, MA, Manenti, E, Ruschel, K, Marin-Neto, J, Pavao, R, Preto, R, Junior, AA, Oliveira, G, Rassi, S, Sampaio, D, Rossi, PR, dos Santos, L, de Souza, J, Lino, E, Filho, PP, Zucchetti, C, Gomes, M, de Paiva, A, Sousa, AC, Almeida, A, Botelho, R, da Silva, R, Giraldez, R, Franken, M, Faludi, A, Bertolami, M, Hernandes, M, Lucas, N, Carvalho, A, Bertolami, A, Precoma, D, Geralde, L, Pereira, A, Cesar, L, Mioto, B, Marino, R, Rabelo, W, dos Santos, F, Vidotti, M, Mangione, J, Mauro, M, Kormann, A, Ultramari, F, Zimmermann, S, Michalaros, Y, Fonseca, M, Sampaio, C, Eliaschewitz, F, Barbosa, E, Drews, C, de Lorenzo, A, Barros, C, Cancado, G, Neuesnchwander, F, Zimmermann, E, Chompalova, B, Denchev, S, Gocheva, N, Mihov, A, Mincheva, V, Gelev, V, Tisheva, S, Todorov, G, Goudev, A, Parvanova, Z, Todorova, M, Mitkova, M, Smilov, L, Yakovova, S, Milanova, K, Aleksov, N, Mollov, M, Shishmanova, D, Hristova, K, Uzunangelov, Y, Peltegov, V, Karamitev, G, Benov, H, Vasileva, D, Parishev, G, Milcheva, N, Avramov, D, Miteva, B, Stoyanovski, V, Pencheva, G, Nikolova, L, Stancheva, N, Nyagina, M, Markov, D, Spirova, D, Peneva, Y, Peshkov, O, Mitkova, L, Mandzhukova, S, Rangelova, V, Ivanov, K, Krusheva, B, Raycheva, V, Gergova, V, Goranov, K, Stoykov, A, Staleva, M, Rashkova, V, Postadzhian, A, Krancheva, V, Lulova, E, Delchev, G, Cantor, W, Constance, C, Gosselin, G, Marr, D, Pandey, A, Pesant, Y, Pouliot, J, Gladstone, P, McPherson, T, Rupka, D, Saw, J, St-Amour, E, Syan, G, Syan, R, Rosenbloom, A, Vizel, S, Della Siega, A, Halperin, F, Nigro, F, Chehayeb, R, Fell, D, Labonte, R, Nawaz, S, Gupta, M, Ma, P, Glanz, A, Kouz, S, Bhargava, R, Dion, D, Dupuis, R, Grondin, F, Wong, B, Sabbah, E, Hui, W, Belisle, P, Tymchak, W, Montigny, M, Lonn, E, Bose, S, Kincade, D, Gallo, R, Lamy, A, Bell, A, Lemay, M, Bata, I, Kostuk, W, Cheung, S, 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Fielding, M, Doorey, A, Squire, A, Suresh, D, Frost, J, Teklinski, A, Stone, B, Waksman, R, Griffin, S, Wharton, W, Blakely, J, Fishbein, G, Weller, C, Camp, A, Fisher, S, Meholick, A, Hejna, E, Anderson, R, Long, S, Parikh, S, Norton, N, Vijay, N, Washam, M, Smith, S, and Stepanov, N
- Abstract
BACKGROUND The potential benefit of dual antiplatelet therapy beyond 1 year after a myocardial infarction has not been established. We investigated the efficacy and safety of ticagrelor, a P2Y(12) receptor antagonist with established efficacy after an acute coronary syndrome, in this context. METHODS We randomly assigned, in a double-blind 1: 1: 1 fashion, 21,162 patients who had had a myocardial infarction 1 to 3 years earlier to ticagrelor at a dose of 90 mg twice daily, ticagrelor at a dose of 60 mg twice daily, or placebo. All the patients were to receive low-dose aspirin and were followed for a median of 33 months. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The primary safety end point was Thrombolysis in Myocardial Infarction (TIMI) major bleeding. RESULTS The two ticagrelor doses each reduced, as compared with placebo, the rate of the primary efficacy end point, with Kaplan-Meier rates at 3 years of 7.85% in the group that received 90 mg of ticagrelor twice daily, 7.77% in the group that received 60 mg of ticagrelor twice daily, and 9.04% in the placebo group (hazard ratio for 90 mg of ticagrelor vs. placebo, 0.85; 95% confidence interval [CI], 0.75 to 0.96; P = 0.008; hazard ratio for 60 mg of ticagrelor vs. placebo, 0.84; 95% CI, 0.74 to 0.95; P = 0.004). Rates of TIMI major bleeding were higher with ticagrelor (2.60% with 90 mg and 2.30% with 60 mg) than with placebo (1.06%) (P < 0.001 for each dose vs. placebo); the rates of intracranial hemorrhage or fatal bleeding in the three groups were 0.63%, 0.71%, and 0.60%, respectively. CONCLUSIONS In patients with a myocardial infarction more than 1 year previously, treatment with ticagrelor significantly reduced the risk of cardiovascular death, myocardial infarction, or stroke and increased the risk of major bleeding. (Funded by AstraZeneca; PEGASUS-TIMI 54 ClinicalTrials.gov number, NCT01225562.)
- Published
- 2015
42. Neurochemical and histological observations after the transplantation of human amniotic epithelial cells in 6-hydroxydomine (6-ohda) lesioned corpus striatum of Wistar albino rats
- Author
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Ravisankar, P., primary, Kumar, R.R., additional, and Muthusamy, R., additional
- Published
- 2016
- Full Text
- View/download PDF
43. Poster Session 2 : Monday 4 May 2015, 08
- Author
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Bouyoucef, S E, Uusitalo, V, Kamperidis, V, De Graaf, M A, Maaniitty, T, Stenstrom, I, Broersen, A, Scholte, A J, Saraste, A, Bax, J J, Knuuti, J, Furuhashi, T, Moroi, M, Awaya, T, Masai, H, Minakawa, M, Kunimasa, T, Fukuda, H, Sugi, K, Berezin, A, Kremzer, A, Clerc, O F, Kaufmann, B, Possner, M, Liga, R, Vontobel, J, Mikulicic, F, Graeni, C, Benz, D C, Kaufmann, P A, Buechel, R B, Ferreira, Mjv, Cunha, M J, Albuquerque, A, Ramos, D, Costa, G, Lima, J, Pego, M, Peix, A, Cisneros, L, Cabrera, L O, Padron, K, Rodriguez, L, Heres, F, Carrillo, R, Mena, E, Fernandez, Y, Huizing, E D, Van Dijk, J D, Van Dalen, J A, Timmer, J R, Ottervanger, J P, Slump, C H, Jager, P L, Venuraju, S, Jeevarethinam, A, Yerramasu, A, Atwal, S, Mehta, V S, Lahiri, A, Arjonilla Lopez, A, Calero Rueda, M J, Gallardo, G, Fernandez-Cuadrado, J, Hernandez Aceituno, D, Sanchez Hernandez, J, Yoshida, H, Mizukami, A, Matsumura, A, Smettei, O, Abazid, R, Sayed, S, Mlynarska, A, Mlynarski, R, Golba, K, Sosnowski, M, Winther, S, Svensson, M, Jorgensen, H S, Bouchelouche, K, Gormsen, L C, Holm, N R, Botker, H E, Ivarsen, P R, Bottcher, M, Cortes, C M, Aramayo G, E N, Daicz, M, Casuscelli, J F, Alaguibe, E D, Neira Sepulveda, A, Cerda, M, Ganum, G E, Embon, M, Vigne, J, Enilorac, B, Lebasnier, A, Valancogne, L, Peyronnet, D, Manrique, A, Agostini, D, Menendez, D, Rajpal, S, Kocherla, C, Acharya, M, Reddy, P, Sazonova, I, Ilushenkova, Yun, Batalov, R E, Rogovskaya, Y V, Lishmanov, Y B, Popov, S V, Varlamova, N V, Prado Diaz, S, Jimenez Rubio, C, Gemma, D, Refoyo Salicio, E, Valbuena Lopez, S C, Moreno Yanguela, M, Torres, M, Fernandez-Velilla, M, Lopez-Sendon, J L, Guzman Martinez, G, Puente, A, Rosales, S, Martinez, C, Cabada, M, Melendez, G M, Ferreira, R, Gonzaga, A, Santos, J, Vijayan, S, Smith, Smg, Smith, M, Muthusamy, R, Takeishi, Y, Oikawa, M, Goral, J L, Napoli, J, Montana, O R, Damico, A C, Quiroz, M C, Damico, A E, Forcada, P J, Schmidberg, J M, Zucchiatti, N E, Olivieri, D B, Dumo, A, Ruano, S, Rakhit, R, Davar, J, Nair, D, Cohen, M, Darko, D, Yokota, S, Maas, Ahe, Mouden, M, Knollema, S, Sanja Mazic, S M, Lazovic, B, Marina Djelic, Mdj, Jelena Suzic Lazic, J S, Tijana Acimovic, T A, Milica Deleva, M D, Vesnina, Z H, Zafrir, N, Bental, T, Mats, I, Solodky, A, Gutstein, A, Hasid, Y, Belzer, D, Kornowski, R, Ben Said, Rim, Ben Mansour, N, Ibn Haj Amor, H, Chourabi, C, Hagui, A, Fehri, W, Hawala, H, Shugushev, Z, Patrikeev, A, Maximkin, D, Chepurnoy, A, Kallianpur, V, Mambetov, A, Dokshokov, G, Teresinska, A, Wozniak, O, Maciag, A, Wnuk, J, Dabrowski, A, Czerwiec, A, Jezierski, J, Biernacka, K, Robinson, J, Prosser, J, Cheung, Gsm, Allan, S, Mcmaster, G, Reid, S, Tarbuck, A, Martin, W, Queiroz, R C, Falcao, A, Giorgi, McP, Imada, R, Nogueira, S A, Chalela, W A, Kalil Filho, R, Meneghetti, W A, Matveev, V V, Bubyenov, A S, Podzolkov, V I, Baranovich, V, Faibushevich, A, Kolzhecova, Y, Volkova, O, Fernandez, J, Lopez, G, Dondi, M, Paez, D, Butcher, Cjt, Reyes, E, Al-Housni, M B, Green, R, Santiago, H, Ghiotto, F, Hinton-Taylor, S, Pottle, A, Mason, M, Underwood, S R, Casans Tormo, I, Diaz-Exposito, R, Plancha-Burguera, E, Elsaban, K, Alsakhri, Hijji, Yoshinaga, K, Ochi, N, Tomiyama, Y, Katoh, C, Inoue, M, Nishida, M, Suzuki, E, Manabe, O, Ito, Y M, Tamaki, N, Tahilyani, A, Jafary, Fahim, Ho Hee Hwa, H H, Ozdemir, S, Kirilmaz, B, Barutcu, A, Tan, Y Z, Celik, F, Sakgoz, S, Cabada Gamboa, M, Puente Barragan, A, Morales Vitorino, N, Medina Servin, M A, Hindorf, C, Akil, S, Hedeer, F, Jogi, J, Engblom, H, Martire, V D, Pis Diez, E R, Martire, M V, Portillo, D O, Hoff, C M, Balche, A, Majgaard, J, Tolbod, L P, Harms, H J, Soerensen, J, Froekiaer, J, Nudi, F, Neri, G, Procaccini, E, Pinto, A, Vetere, M, Biondi-Zoccai, G, Soares, J, Do Val, R, Oliveira, M A, Meneghetti, J C, Tekabe, Y, Anthony, T, Li, Q, Schmidt, A M, Johnson, L, Groenman, M, Tarkia, M, Kakela, M, Halonen, P, Kiviniemi, T, Pietila, M, Yla-Herttuala, S, Roivainen, A, Nekolla, S, Swirzek, S, Higuchi, T, Reder, S, Schachoff, S, Bschorner, M, Laitinen, I, Robinson, S, Yousefi, B, Schwaiger, M, Kero, Tanja, Lindsjo, L, Antoni, Gunnar, Westermark, P, Carlson, K, Wikstrom, G, Sörensen, Jens, Lubberink, Mark, Rouzet, F, Cognet, T, Guedj, K, Morvan, M, El Shoukr, F, Louedec, L, Choqueux, C, Nicoletti, A, Le Guludec, D, Jimenez-Heffernan, A, Munoz-Beamud, F, Sanchez De Mora, E, Borrachero, C, Salgado, C, Ramos-Font, C, Lopez-Martin, J, Hidalgo, M L, Lopez-Aguilar, R, Soriano, E, Okizaki, A, Nakayama, M, Ishitoya, S, Sato, J, Takahashi, K, Burchert, I, Caobelli, F, Wollenweber, T, Nierada, M, Fulsche, J, Dieckmann, C, Bengel, F M, Shuaib, S, Mahlum, D, Port, S, Refoyo, E, Cuesta, E, Guzman, G, Lopez, T, Valbuena, S, Del Prado, S, Moreno, M, Harbinson, M, Donnelly, L, Einstein, A J, Johnson, L L, Deluca, A J, Kontak, A C, Groves, D W, Stant, J, Pozniakoff, T, Cheng, B, Rabbani, L E, Bokhari, S, Schuetze, C, Aguade-Bruix, S, Pizzi, M N, Romero-Farina, G, Terricabras, M, Villasboas, D, Castell-Conesa, J, Candell-Riera, J, Brunner, S, Gross, L, Todica, A, Lehner, S, Di Palo, A, Niccoli Asabella, A, Magarelli, C, Notaristefano, A, Ferrari, C, Rubini, G, Sellem, A, Melki, S, Elajmi, W, Hammami, H, Ziadi, M C, Montero, J, Ameriso, J L, Villavicencio, R L, Benito Gonzalez, T F, Mayorga Bajo, A, Gutierrez Caro, R, Rodriguez Santamarta, M, Alvarez Roy, L, Martinez Paz, E, Barinaga Martin, C, Martin Fernandez, J, Alonso Rodriguez, D, Iglesias Garriz, I, Rosillo, S, Taleb, S, Cherkaoui Salhi, G, Regbaoui, Y, Ait Idir, M, Guensi, A, Martin Lopez, C E, Castano Ruiz, M, Bouyoucef, S E, Uusitalo, V, Kamperidis, V, De Graaf, M A, Maaniitty, T, Stenstrom, I, Broersen, A, Scholte, A J, Saraste, A, Bax, J J, Knuuti, J, Furuhashi, T, Moroi, M, Awaya, T, Masai, H, Minakawa, M, Kunimasa, T, Fukuda, H, Sugi, K, Berezin, A, Kremzer, A, Clerc, O F, Kaufmann, B, Possner, M, Liga, R, Vontobel, J, Mikulicic, F, Graeni, C, Benz, D C, Kaufmann, P A, Buechel, R B, Ferreira, Mjv, Cunha, M J, Albuquerque, A, Ramos, D, Costa, G, Lima, J, Pego, M, Peix, A, Cisneros, L, Cabrera, L O, Padron, K, Rodriguez, L, Heres, F, Carrillo, R, Mena, E, Fernandez, Y, Huizing, E D, Van Dijk, J D, Van Dalen, J A, Timmer, J R, Ottervanger, J P, Slump, C H, Jager, P L, Venuraju, S, Jeevarethinam, A, Yerramasu, A, Atwal, S, Mehta, V S, Lahiri, A, Arjonilla Lopez, A, Calero Rueda, M J, Gallardo, G, Fernandez-Cuadrado, J, Hernandez Aceituno, D, Sanchez Hernandez, J, Yoshida, H, Mizukami, A, Matsumura, A, Smettei, O, Abazid, R, Sayed, S, Mlynarska, A, Mlynarski, R, Golba, K, Sosnowski, M, Winther, S, Svensson, M, Jorgensen, H S, Bouchelouche, K, Gormsen, L C, Holm, N R, Botker, H E, Ivarsen, P R, Bottcher, M, Cortes, C M, Aramayo G, E N, Daicz, M, Casuscelli, J F, Alaguibe, E D, Neira Sepulveda, A, Cerda, M, Ganum, G E, Embon, M, Vigne, J, Enilorac, B, Lebasnier, A, Valancogne, L, Peyronnet, D, Manrique, A, Agostini, D, Menendez, D, Rajpal, S, Kocherla, C, Acharya, M, Reddy, P, Sazonova, I, Ilushenkova, Yun, Batalov, R E, Rogovskaya, Y V, Lishmanov, Y B, Popov, S V, Varlamova, N V, Prado Diaz, S, Jimenez Rubio, C, Gemma, D, Refoyo Salicio, E, Valbuena Lopez, S C, Moreno Yanguela, M, Torres, M, Fernandez-Velilla, M, Lopez-Sendon, J L, Guzman Martinez, G, Puente, A, Rosales, S, Martinez, C, Cabada, M, Melendez, G M, Ferreira, R, Gonzaga, A, Santos, J, Vijayan, S, Smith, Smg, Smith, M, Muthusamy, R, Takeishi, Y, Oikawa, M, Goral, J L, Napoli, J, Montana, O R, Damico, A C, Quiroz, M C, Damico, A E, Forcada, P J, Schmidberg, J M, Zucchiatti, N E, Olivieri, D B, Dumo, A, Ruano, S, Rakhit, R, Davar, J, Nair, D, Cohen, M, Darko, D, Yokota, S, Maas, Ahe, Mouden, M, Knollema, S, Sanja Mazic, S M, Lazovic, B, Marina Djelic, Mdj, Jelena Suzic Lazic, J S, Tijana Acimovic, T A, Milica Deleva, M D, Vesnina, Z H, Zafrir, N, Bental, T, Mats, I, Solodky, A, Gutstein, A, Hasid, Y, Belzer, D, Kornowski, R, Ben Said, Rim, Ben Mansour, N, Ibn Haj Amor, H, Chourabi, C, Hagui, A, Fehri, W, Hawala, H, Shugushev, Z, Patrikeev, A, Maximkin, D, Chepurnoy, A, Kallianpur, V, Mambetov, A, Dokshokov, G, Teresinska, A, Wozniak, O, Maciag, A, Wnuk, J, Dabrowski, A, Czerwiec, A, Jezierski, J, Biernacka, K, Robinson, J, Prosser, J, Cheung, Gsm, Allan, S, Mcmaster, G, Reid, S, Tarbuck, A, Martin, W, Queiroz, R C, Falcao, A, Giorgi, McP, Imada, R, Nogueira, S A, Chalela, W A, Kalil Filho, R, Meneghetti, W A, Matveev, V V, Bubyenov, A S, Podzolkov, V I, Baranovich, V, Faibushevich, A, Kolzhecova, Y, Volkova, O, Fernandez, J, Lopez, G, Dondi, M, Paez, D, Butcher, Cjt, Reyes, E, Al-Housni, M B, Green, R, Santiago, H, Ghiotto, F, Hinton-Taylor, S, Pottle, A, Mason, M, Underwood, S R, Casans Tormo, I, Diaz-Exposito, R, Plancha-Burguera, E, Elsaban, K, Alsakhri, Hijji, Yoshinaga, K, Ochi, N, Tomiyama, Y, Katoh, C, Inoue, M, Nishida, M, Suzuki, E, Manabe, O, Ito, Y M, Tamaki, N, Tahilyani, A, Jafary, Fahim, Ho Hee Hwa, H H, Ozdemir, S, Kirilmaz, B, Barutcu, A, Tan, Y Z, Celik, F, Sakgoz, S, Cabada Gamboa, M, Puente Barragan, A, Morales Vitorino, N, Medina Servin, M A, Hindorf, C, Akil, S, Hedeer, F, Jogi, J, Engblom, H, Martire, V D, Pis Diez, E R, Martire, M V, Portillo, D O, Hoff, C M, Balche, A, Majgaard, J, Tolbod, L P, Harms, H J, Soerensen, J, Froekiaer, J, Nudi, F, Neri, G, Procaccini, E, Pinto, A, Vetere, M, Biondi-Zoccai, G, Soares, J, Do Val, R, Oliveira, M A, Meneghetti, J C, Tekabe, Y, Anthony, T, Li, Q, Schmidt, A M, Johnson, L, Groenman, M, Tarkia, M, Kakela, M, Halonen, P, Kiviniemi, T, Pietila, M, Yla-Herttuala, S, Roivainen, A, Nekolla, S, Swirzek, S, Higuchi, T, Reder, S, Schachoff, S, Bschorner, M, Laitinen, I, Robinson, S, Yousefi, B, Schwaiger, M, Kero, Tanja, Lindsjo, L, Antoni, Gunnar, Westermark, P, Carlson, K, Wikstrom, G, Sörensen, Jens, Lubberink, Mark, Rouzet, F, Cognet, T, Guedj, K, Morvan, M, El Shoukr, F, Louedec, L, Choqueux, C, Nicoletti, A, Le Guludec, D, Jimenez-Heffernan, A, Munoz-Beamud, F, Sanchez De Mora, E, Borrachero, C, Salgado, C, Ramos-Font, C, Lopez-Martin, J, Hidalgo, M L, Lopez-Aguilar, R, Soriano, E, Okizaki, A, Nakayama, M, Ishitoya, S, Sato, J, Takahashi, K, Burchert, I, Caobelli, F, Wollenweber, T, Nierada, M, Fulsche, J, Dieckmann, C, Bengel, F M, Shuaib, S, Mahlum, D, Port, S, Refoyo, E, Cuesta, E, Guzman, G, Lopez, T, Valbuena, S, Del Prado, S, Moreno, M, Harbinson, M, Donnelly, L, Einstein, A J, Johnson, L L, Deluca, A J, Kontak, A C, Groves, D W, Stant, J, Pozniakoff, T, Cheng, B, Rabbani, L E, Bokhari, S, Schuetze, C, Aguade-Bruix, S, Pizzi, M N, Romero-Farina, G, Terricabras, M, Villasboas, D, Castell-Conesa, J, Candell-Riera, J, Brunner, S, Gross, L, Todica, A, Lehner, S, Di Palo, A, Niccoli Asabella, A, Magarelli, C, Notaristefano, A, Ferrari, C, Rubini, G, Sellem, A, Melki, S, Elajmi, W, Hammami, H, Ziadi, M C, Montero, J, Ameriso, J L, Villavicencio, R L, Benito Gonzalez, T F, Mayorga Bajo, A, Gutierrez Caro, R, Rodriguez Santamarta, M, Alvarez Roy, L, Martinez Paz, E, Barinaga Martin, C, Martin Fernandez, J, Alonso Rodriguez, D, Iglesias Garriz, I, Rosillo, S, Taleb, S, Cherkaoui Salhi, G, Regbaoui, Y, Ait Idir, M, Guensi, A, Martin Lopez, C E, and Castano Ruiz, M
- Published
- 2015
- Full Text
- View/download PDF
44. Thrombin-receptor antagonist vorapaxar in acute coronary syndromes
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Tricoci, P, Huang, Z, Held, C, Moliterno, Dj, Armstrong, Pw, Van de Werf, F, White, Hd, Aylward, Pe, Wallentin, L, Chen, E, Lokhnygina, Y, Pei, J, Leonardi, S, Rorick, Tl, Kilian, Am, Jennings, Lh, Ambrosio, G, Bode, C, Cequier, A, Cornel, Jh, Diaz, R, Erkan, A, Huber, K, Hudson, Mp, Jiang, L, Jukema, Jw, Lewis, Bs, Lincoff, Am, Montalescot, G, Nicolau, Jc, Ogawa, H, Pfisterer, M, Prieto, Jc, Ruzyllo, W, Sinnaeve, Pr, Storey, Rf, Valgimigli, M, Whellan, Dj, Widimsky, P, Strony, J, Harrington, Ra, Mahaffey, Kw, Huo, Y, Lixin, J, Isaza, D, Grande, P, Laine, M, Wong, L, Ofner, P, Yamaguchi, T, Park, Sj, Nordrehaug, Je, Providencia, L, Cheem, Th, Dalby, A, Betriu, A, Chen, Mf, Verheugt, F, Frye, Rl, Hochman, J, Steg, Pg, Bailey, Kr, Easton, Jd, Lincoff, A, Underwood, Fd, Wrestler, J, Larson, D, Vandyne, B, Kilian, A, Harmelin-Kadouri, R, Layton, L, Lipka, L, Petrauskas, S, Qidwai, M, Sorochuck, C, Temple, T, Mason, D, Sydlowski, D, Gallagher, B, Villasin, A, Beernaert, A, Douglas, S, Garrett, J, Wiering, J, Adriaenssens, T, Ganame, J, Hulselmans, M, Katz, Jn, Kayaert, P, La Gerche, A, Onsea, K, Zalewski, J, Johnson, A, O'Briant, J, Smith, M, Akerblom, A, Armaganijan, L, Bertolami, A, Brennan, M, da Ponte Nacif SA, de Campos Gonzaga, C, Dequadros, A, Déry, Jp, Dev, S, Ducrocq, G, Eapen, Zp, Echenique, L, Eggers, K, Garcia, H, Guimaraes, Hp, Hagstrom, E, Hanet, C, James, S, Jonelid, B, Kolls, Bj, Leiria, T, Leite, R, Lombardi, C, Lopes, Rd, Malagutti, P, Mathews, R, Mehta, Rh, Melloni, C, Piccini, Jp, Rodriques Soares, P, Roe, Mt, Shah, Br, Stashenko, G, Szczech, La, Truffa, A, Varenhorst, C, Vranckx, P, Williams, J, Kilaru, R, White, Ja, Binkowitz, B, He, W, Ramos, Ms, Hasbani, E, Farras, Ha, Luz del Valle, L, Zapata, G, Centeno, Ep, Hominal, M, Beloscar, J, Panno, M, Berli, M, Carlevaro, O, Wasserman, T, Lembo, L, Diez, F, Bettinotti, M, Allall, O, Macin, S, Hii, C, Bett, N, Aroney, C, Roberts-Thomson, P, Arstall, M, Horowitz, J, Prasan, A, Farshid, A, Rankin, J, Duffy, S, Sinhal, A, Hendricks, R, Waites, J, Hill, A, French, J, Adams, M, Soward, A, Dick, R, Jepson, N, Nelson, G, Thompson, P, Neunteufl, T, Pachinger, O, Leisch, F, Siostrzonek, P, Roithinger, F, Pieske, B, Weber, H, Eber, B, Zenker, G, Sinnaeve, P, Roosen, J, Vervoort, G, Coussement, P, Striekwold, H, Boland, J, Van Dorpe, A, Dujardin, K, Mertens, D, Vanneste, L, Celen, H, Lesseliers, H, Vrolix, M, Leone, A, De Maeseneire, S, Hellemans, S, Silva, Fa, Franken, M, Moraes JB Jr, Mora, R, Michalaros, Y, Perin, M, Guimaraes, Ae, da Silva DG, Mattos, Ma, Alves AR Jr, Hernandes, Me, Golin, V, da Silva SA, Ardito, W, Dery, Jp, Mukherjee, A, Tanguay, Jf, Kornder, J, Lutchmedial, S, Degrace, M, Klinke, P, Constance, C, Nogareda, G, Wong, G, Macdonald, P, Senaratne, M, Rupka, D, Halperin, F, Ramanathan, K, Natarajan, M, Lai, C, Brossoit, R, Tymchak, W, Rose, B, Dupuis, R, Mansour, S, Bata, I, Zadra, R, Turek, M, Madan, M, Le May, M, Leon, L, Perez, L, Yovaniniz, P, Pedemonte, O, Campos, P, Pincetti, C, Sepulveda, P, Li, W, Zhao, R, Li, Z, Yang, Y, Chen, J, Li, H, Jiang, Y, Li, D, Qu, P, Sun, Y, Zheng, Y, Zhou, C, Zhang, F, Wei, M, Wang, D, Lemus, J, Fernandez, Rl, Jaramillo, C, Ochoa, J, Velez, S, Cano, N, Lutz, J, Botero, R, Jaramillo, M, Saaib, J, Sanchez, G, Hernandez, H, Mendoza, F, Rizcala, A, Urina, M, Polasek, R, Motovska, Z, Zemanek, D, Ostransky, J, Kettner, J, Spinar, J, Groch, L, Ramik, C, Stumar, J, Linhart, A, Pleva, L, Niedobova, E, Macha, J, Vojacek, J, Stipal, R, Galatius, S, Eggert, S, Mickley, H, Egstrup, K, Pedersen, O, Hvilsted, L, Sykulski, R, Skagen, K, Dodt, K, Klarlund, K, Husted, S, Jensen, G, Melchior, T, Sjoel, A, Steffensen, Fh, Airaksinen, Ke, Laukkanen, Ja, Syvanne, Ms, Kotila, Mj, Mikael, K, Naveri, Hk, Hekkala, Am, Mustonen, Jn, Halkosaari, M, Ohlmann, P, Khalife, K, Dibon, O, Hirsch, Jl, Furber, A, Nguyen-Khac, Jo, Delarche, N, Probst, V, Lim, P, Bayet, G, Dauphin, R, Levai, L, Galinier, M, Belhassane, A, Wiedemann, Jy, Fouche, R, Coisne, 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Loboz-Grudzien, K, Lewczuk, J, Karwowski, D, Grajek, S, Dudek, D, Trusz-Gluza, M, Kornacewicz-Jach, Z, Gil, R, Ferreira, J, Gavina, C, Ferreira, R, Martins, D, Garcia-Rinaldi, R, Ufret, R, Vazquez-Tanus, J, Banchs, H, Wong, A, Tan, Hc, Guerra, M, Ebrahim, I, Roux, J, Blomerus, P, Saaiman, A, Corbett, C, Pillay, T, Freeman, V, Horak, A, Zambakides, C, Burgess, L, Yoon, Jh, Ahn, Th, Gwon, Hc, Seong, Iw, Kim, Hs, Jeong, Mh, Kim, Yd, Chae, Sc, Hernandez, Jm, Pique, M, Fernandez Portales, J, Paz, Ma, Lopez Palop, R, Iniguez, A, Diaz Fernandez, J, Alvarez, P, Sanz, E, Heras, M, Sala, J, Goicolea, J, Cruz Fernandez, J, Serra, A, Fernandez Ortiz, A, Calle, G, Barriales, V, Albarran, A, Curos, A, Molano Casimiro FJ, Suarez, Ma, Franco, Sn, Bayon, J, Suarez, J, Belchi, J, Moreu, J, San Martin, M, Melgares Moreno, R, Aguirre Salcedo, J, Gonzalez Juanatey JR, Martinez Romero, P, Galache Osuna JG, Albertsson, P, Diderholm, E, Lycksell, M, Rasmanis, G, Swahn, E, Cherfan, P, Christensen, K, Lundman, P, Larson, Le, Vasko, P, Pripp, Cm, Johansson, A, Moccetti, T, Corti, R, Pieper, M, Mach, F, Eberli, F, Jeger, R, Rickli, H, Vogt, P, Windecker, S, Wu, Cj, Kao, Hl, Charng, Mj, Chang, Kc, Chen, Zc, Tsa, Cd, Shyu, Kg, Lai, Wt, Hsieh, Ic, Hou, Jy, Yeh, Hi, Ueng, Kc, Yin, Wh, Timurkaynak, T, Yigit, Z, Yilmaz, M, Boyaci, A, Sahin, M, Goktekin, O, Bozkurt, E, Ercan, E, Yildirir, A, Muthusamy, R, Keeling, P, Levy, T, Zaman, A, Cohen, A, Gorog, D, Baumbach, A, Oldroyd, K, Kadr, H, Tait, G, Bellenger, N, Davis, G, Shakespeare, C, Senior, R, Bruce, D, Uren, N, Trouton, T, Ahsan, A, Hamed, A, Malik, I, Sarma, J, Millar-Craig, M, Robson, H, Kennon, S, Sprigings, D, Brodie, B, Kang, Gs, Thomas, G, Cheng, Sc, Espinoza, A, Kassas, S, Jafar, Z, Kumar, P, Izzo, M, Wiseman, A, Chandna, H, Felten, W, D'Urso, M, Gudipati, Cr, Coram, R, Gill, S, Bengtson, J, Chang, M, Raisinghani, A, Blankenship, J, Harbor, Wf, Kraft, P, Ashraf, R, Chambers, J, Albirini, A, Malik, A, Ziada, K, Slepian, M, Taussig, A, 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R, Kleczka, J, Silver, K, Coleman, P, Brachfeld, C, Saltiel, F, Reiner, J, Carell, E, Hanovich, G, Rosenberg, M, Das, G, Blick, D, and Universitat de Barcelona
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Male ,Pyridines ,medicine.medical_treatment ,Kaplan-Meier Estimate ,law.invention ,Lactones ,Randomized controlled trial ,law ,Thrombin receptor antagonist ,clopidogrel ,placebo ,thienopyridine derivative ,vorapaxar ,antithrombocytic agent ,lactone ,proteinase activated receptor 1 ,pyridine derivative ,Coronary Artery Bypass ,Vorapaxar ,Cardiovascular diseases [NCEBP 14] ,Drugs ,General Medicine ,Middle Aged ,Combined Modality Therapy ,Cardiovascular diseases ,Cardiovascular Diseases ,Cardiology ,Platelet aggregation inhibitor ,Drug Therapy, Combination ,Female ,Plaquetes sanguínies ,Intracranial Hemorrhages ,Major bleeding ,Medicaments ,medicine.drug ,medicine.medical_specialty ,Acute coronary syndrome ,Bypass cardiopulmonary ,Hemorrhage ,Pharmacotherapy ,Blood platelets ,Double-Blind Method ,Angioplasty ,Internal medicine ,medicine ,Humans ,Receptor, PAR-1 ,Acute Coronary Syndrome ,Aged ,business.industry ,Malalties cardiovasculars ,medicine.disease ,Surgery ,Bypass cardiopulmonar ,business ,Platelet Aggregation Inhibitors ,Follow-Up Studies - Abstract
Item does not contain fulltext BACKGROUND: Vorapaxar is a new oral protease-activated-receptor 1 (PAR-1) antagonist that inhibits thrombin-induced platelet activation. METHODS: In this multinational, double-blind, randomized trial, we compared vorapaxar with placebo in 12,944 patients who had acute coronary syndromes without ST-segment elevation. The primary end point was a composite of death from cardiovascular causes, myocardial infarction, stroke, recurrent ischemia with rehospitalization, or urgent coronary revascularization. RESULTS: Follow-up in the trial was terminated early after a safety review. After a median follow-up of 502 days (interquartile range, 349 to 667), the primary end point occurred in 1031 of 6473 patients receiving vorapaxar versus 1102 of 6471 patients receiving placebo (Kaplan-Meier 2-year rate, 18.5% vs. 19.9%; hazard ratio, 0.92; 95% confidence interval [CI], 0.85 to 1.01; P=0.07). A composite of death from cardiovascular causes, myocardial infarction, or stroke occurred in 822 patients in the vorapaxar group versus 910 in the placebo group (14.7% and 16.4%, respectively; hazard ratio, 0.89; 95% CI, 0.81 to 0.98; P=0.02). Rates of moderate and severe bleeding were 7.2% in the vorapaxar group and 5.2% in the placebo group (hazard ratio, 1.35; 95% CI, 1.16 to 1.58; P
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- 2012
45. Involvement of metabolic resistance and F1534C kdr mutation in the pyrethroid resistance mechanisms of Aedes aegypti in India
- Author
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Muthusamy, R., primary and Shivakumar, M.S., additional
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- 2015
- Full Text
- View/download PDF
46. Poster Session 2: Monday 4 May 2015, 08:00-18:00 * Room: Poster Area
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Bouyoucef, S. E., primary, Uusitalo, V., additional, Kamperidis, V., additional, De Graaf, M., additional, Maaniitty, T., additional, Stenstrom, I., additional, Broersen, A., additional, Scholte, A., additional, Saraste, A., additional, Bax, J., additional, Knuuti, J., additional, Furuhashi, T., additional, Moroi, M., additional, Awaya, T., additional, Masai, H., additional, Minakawa, M., additional, Kunimasa, T., additional, Fukuda, H., additional, Sugi, K., additional, Berezin, A., additional, Kremzer, A., additional, Clerc, O., additional, Kaufmann, B., additional, Possner, M., additional, Liga, R., additional, Vontobel, J., additional, Mikulicic, F., additional, Graeni, C., additional, Benz, D., additional, Kaufmann, P., additional, Buechel, R., additional, Ferreira, M., additional, Cunha, M., additional, Albuquerque, A., additional, Ramos, D., additional, Costa, G., additional, Lima, J., additional, Pego, M., additional, Peix, A., additional, Cisneros, L., additional, Cabrera, L., additional, Padron, K., additional, Rodriguez, L., additional, Heres, F., additional, Carrillo, R., additional, Mena, E., additional, Fernandez, Y., additional, Huizing, E., additional, Van Dijk, J., additional, Van Dalen, J., additional, Timmer, J., additional, Ottervanger, J., additional, Slump, C., additional, Jager, P., additional, Venuraju, S., additional, Jeevarethinam, A., additional, Yerramasu, A., additional, Atwal, S., additional, Mehta, V., additional, Lahiri, A., additional, Arjonilla Lopez, A., additional, Calero Rueda, M. J., additional, Gallardo, G., additional, Fernandez-Cuadrado, J., additional, Hernandez Aceituno, D., additional, Sanchez Hernandez, J., additional, Yoshida, H., additional, Mizukami, A., additional, Matsumura, A., additional, Smettei, O., additional, Abazid, R., additional, Sayed, S., additional, Mlynarska, A., additional, Mlynarski, R., additional, Golba, K., additional, Sosnowski, M., additional, Winther, S., additional, Svensson, M., additional, Jorgensen, H., additional, Bouchelouche, K., additional, Gormsen, L., additional, Holm, N., additional, Botker, H., additional, Ivarsen, P., additional, Bottcher, M., additional, Cortes, C. 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L., additional, Napoli, J., additional, Montana, O., additional, Damico, A., additional, Quiroz, M., additional, Forcada, P., additional, Schmidberg, J., additional, Zucchiatti, N., additional, Olivieri, D., additional, Dumo, A., additional, Ruano, S., additional, Rakhit, R., additional, Davar, J., additional, Nair, D., additional, Cohen, M., additional, Darko, D., additional, Yokota, S., additional, Maas, A., additional, Mouden, M., additional, Knollema, S., additional, Sanja Mazic, S., additional, Lazovic, B., additional, Marina Djelic, M., additional, Jelena Suzic Lazic, J., additional, Tijana Acimovic, T., additional, Milica Deleva, M., additional, Vesnina, Z., additional, Zafrir, N., additional, Bental, T., additional, Mats, I., additional, Solodky, A., additional, Gutstein, A., additional, Hasid, Y., additional, Belzer, D., additional, Kornowski, R., additional, Ben Said, R., additional, Ben Mansour, N., additional, Ibn Haj Amor, H., additional, Chourabi, C., additional, Hagui, A., additional, Fehri, W., additional, Hawala, H., additional, Shugushev, Z., additional, Patrikeev, A., additional, Maximkin, D., additional, Chepurnoy, A., additional, Kallianpur, V., additional, Mambetov, A., additional, Dokshokov, G., additional, Teresinska, A., additional, Wozniak, O., additional, Maciag, A., additional, Wnuk, J., additional, Dabrowski, A., additional, Czerwiec, A., additional, Jezierski, J., additional, Biernacka, K., additional, Robinson, J., additional, Prosser, J., additional, Cheung, G., additional, Allan, S., additional, Mcmaster, G., additional, Reid, S., additional, Tarbuck, A., additional, Martin, W., additional, Queiroz, R., additional, Falcao, A., additional, Giorgi, M., additional, Imada, R., additional, Nogueira, S., additional, Chalela, W., additional, Kalil Filho, R., additional, Meneghetti, W., additional, Matveev, V., additional, Bubyenov, A., additional, Podzolkov, V., additional, Baranovich, V., additional, Faibushevich, A., additional, Kolzhecova, Y., additional, Volkova, O., additional, Fernandez, J., additional, Lopez, G., additional, Dondi, M., additional, Paez, D., additional, Butcher, C., additional, Reyes, E., additional, Al-Housni, M., additional, Green, R., additional, Santiago, H., additional, Ghiotto, F., additional, Hinton-Taylor, S., additional, Pottle, A., additional, Mason, M., additional, Underwood, S., additional, Casans Tormo, I., additional, Diaz-Exposito, R., additional, Plancha-Burguera, E., additional, Elsaban, K., additional, Alsakhri, H., additional, Yoshinaga, K., additional, Ochi, N., additional, Tomiyama, Y., additional, Katoh, C., additional, Inoue, M., additional, Nishida, M., additional, Suzuki, E., additional, Manabe, O., additional, Ito, Y., additional, Tamaki, N., additional, Tahilyani, A., additional, Jafary, F., additional, Ho Hee Hwa, H., additional, Ozdemir, S., additional, Kirilmaz, B., additional, Barutcu, A., additional, Tan, Y., additional, Celik, F., additional, Sakgoz, S., additional, Cabada Gamboa, M., additional, Puente Barragan, A., additional, Morales Vitorino, N., additional, Medina Servin, M., additional, Hindorf, C., additional, Akil, S., additional, Hedeer, F., additional, Jogi, J., additional, Engblom, H., additional, Martire, V., additional, Pis Diez, E., additional, Martire, M., additional, Portillo, D., additional, Hoff, C., additional, Balche, A., additional, Majgaard, J., additional, Tolbod, L., additional, Harms, H., additional, Soerensen, J., additional, Froekiaer, J., additional, Nudi, F., additional, Neri, G., additional, Procaccini, E., additional, Pinto, A., additional, Vetere, M., additional, Biondi-Zoccai, G., additional, Soares, J., additional, Do Val, R., additional, Oliveira, M., additional, Meneghetti, J., additional, Tekabe, Y., additional, Anthony, T., additional, Li, Q., additional, Schmidt, A., additional, Johnson, L., additional, Groenman, M., additional, Tarkia, M., additional, Kakela, M., additional, Halonen, P., additional, Kiviniemi, T., additional, Pietila, M., additional, Yla-Herttuala, S., additional, Roivainen, A., additional, Nekolla, S., additional, Swirzek, S., additional, Higuchi, T., additional, Reder, S., additional, Schachoff, S., additional, Bschorner, M., additional, Laitinen, I., additional, Robinson, S., additional, Yousefi, B., additional, Schwaiger, M., additional, Kero, T., additional, Lindsjo, L., additional, Antoni, G., additional, Westermark, P., additional, Carlson, K., additional, Wikstrom, G., additional, Sorensen, J., additional, Lubberink, M., additional, Rouzet, F., additional, Cognet, T., additional, Guedj, K., additional, Morvan, M., additional, El Shoukr, F., additional, Louedec, L., additional, Choqueux, C., additional, Nicoletti, A., additional, Le Guludec, D., additional, Jimenez-Heffernan, A., additional, Munoz-Beamud, F., additional, Sanchez De Mora, E., additional, Borrachero, C., additional, Salgado, C., additional, Ramos-Font, C., additional, Lopez-Martin, J., additional, Hidalgo, M., additional, Lopez-Aguilar, R., additional, Soriano, E., additional, Okizaki, A., additional, Nakayama, M., additional, Ishitoya, S., additional, Sato, J., additional, Takahashi, K., additional, Burchert, I., additional, Caobelli, F., additional, Wollenweber, T., additional, Nierada, M., additional, Fulsche, J., additional, Dieckmann, C., additional, Bengel, F., additional, Shuaib, S., additional, Mahlum, D., additional, Port, S., additional, Refoyo, E., additional, Cuesta, E., additional, Guzman, G., additional, Lopez, T., additional, Valbuena, S., additional, Del Prado, S., additional, Moreno, M., additional, Harbinson, M., additional, Donnelly, L., additional, Einstein, A. J., additional, Johnson, L. L., additional, Deluca, A. J., additional, Kontak, A. C., additional, Groves, D. W., additional, Stant, J., additional, Pozniakoff, T., additional, Cheng, B., additional, Rabbani, L. E., additional, Bokhari, S., additional, Schuetze, C., additional, Aguade-Bruix, S., additional, Pizzi, M., additional, Romero-Farina, G., additional, Terricabras, M., additional, Villasboas, D., additional, Castell-Conesa, J., additional, Candell-Riera, J., additional, Brunner, S., additional, Gross, L., additional, Todica, A., additional, Lehner, S., additional, Di Palo, A., additional, Niccoli Asabella, A., additional, Magarelli, C., additional, Notaristefano, A., additional, Ferrari, C., additional, Rubini, G., additional, Sellem, A., additional, Melki, S., additional, Elajmi, W., additional, Hammami, H., additional, Ziadi, M., additional, Montero, J., additional, Ameriso, J., additional, Villavicencio, R., additional, Benito Gonzalez, T. F., additional, Mayorga Bajo, A., additional, Gutierrez Caro, R., additional, Rodriguez Santamarta, M., additional, Alvarez Roy, L., additional, Martinez Paz, E., additional, Barinaga Martin, C., additional, Martin Fernandez, J., additional, Alonso Rodriguez, D., additional, Iglesias Garriz, I., additional, Rosillo, S., additional, Taleb, S., additional, Cherkaoui Salhi, G., additional, Regbaoui, Y., additional, Ait Idir, M., additional, Guensi, A., additional, Martin Lopez, C. E., additional, and Castano Ruiz, M., additional
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- 2015
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47. Resistance selection and molecular mechanisms of cypermethrin resistance in red hairy caterpillar (Amsacta albistriga walker)
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Muthusamy, R., primary and Shivakumar, M.S., additional
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- 2015
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48. Biochemical mechanism of chlorantraniliprole resistance in Spodoptera litura (Fab) (Lepidoptera: Noctuidae)
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Muthusamy, R., primary, Vishnupriya, M., additional, and Shivakumar, M.S., additional
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- 2014
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49. Effectiveness of Mobilization to Sitting in Improving Arousal at Various Durations in Traumatic Brain Injury Patients
- Author
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Nagarathinam, Venkatesh, Muthusamy, Rajeswari, and Ramachandran, Sivakumar
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- 2019
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50. Intravenous NPA for the treatment of infarcting myocardium early; InTIME-II, a double-blind comparison of single-bolus lanoteplase vs accelerated alteplase for the treatment of patients with acute myocardial infarction
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Braunwald, E., Neuhaus, K. -L., Antman, E., Chew, P., Skene, A., Wilcox, R., Ambrosioni, E., Anderson, J., Apetrei, E., Bata, I., Carrageta, M., Col, J., Dalby, A., Davies, R., Deckers, J., Eichman, D., Grande, P., Greene, R., Gurfinkel, E., Heikkilä, J., Henry, T., Hillis, D., Hochman, J., Huber, K., Kostis, J., Klinke, P., López-Sendón, J., Mckendall, G., Móller, B., Moore, P., Morris, A., Mueller, H., Östör, E., Oto, A., Ruda, M., Sadowski, Z., Schweiger, M., Sequeira, R., Shah, P., Shannon, R., Smith, B., Sobel, B., Steingart, R., Tebbe, U., Toman, J., Traboulsi, M., Vahanian, A., Warnica, J. W., Willerson, J., Deitchman, D., Davidson, L., Folgia, T., Foxley, A., Goodman, J., Hauck, C., Henry, D., Mccabe, C., Pangerl, A., Thomson, A., Wagner, M., Kennedy, J. W., Cairns, J., Demets, D., Julian, D., Simoons, M., Charlesworth, A., Easton, J. D., Ferbert, A., Feske, S., Kuhn, P., Moseley, J., Rogg, J. M., Reichmann, H., Sloan, M., von Kummer, R., Zamani, A., Coulter, S., Giugliano, R., Skene, A. M., Ardill, R., Ince, Y., Peters, A., Ward, K., Wolf, L., Curtis, N., De Brés, J., Stead, S., Watson, S., Cutler, S., Friedman, J., Helfrick, R., Williams, S., Klimovsky, J., Kumagai, S., Adams, E., Anderson, C., Bauhuber, I., Bennett, L., Biro, E., Boyce, E., Bregman, B., Carvalho, P., Ciganovic, D., Csukas, M., Cuenca, P., De Cuyper, S., Diez, P., Dijkhuizen, M., Dille-Amo, C., Gonzalez-Santis, A., Gursoy, M., Hammarstrom, K., Harasta, E., Ingman, E., Kelemen, B., Keulen, I., Koren, A., Langthaler, G., Lemaire, F., Little, I., Montalban, C., Nijssen, K., Neumueller, I., Palander, M., Pekuri, T., Persson, U., Pilz, J., Oudotova, S., Pisklakov, V., Proinov, F., Ptaszynska, A., Read, J., Retei, S., Romeyer, F., Romanini, M., Saar, L., Salein, D., Samsonov, M., Simeon-Dubach, D., Simmonds, J., Skaza, M., Skvortsova, N., Smidlova, Z., Spitzerova, H., Strijdveen, I., Szajewski, T., Ugurnal, B., Valcarce, M., van Rompaey, I., Walker, A., Zak, E., Zimova, N., Barrero, C., Beck, E., Bruno, M. 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F., Ashton, T., Baillie, H., Bhargava, R., Bota, G., Cameron, W., Chan, N., Chan, Y. K., Daly, P. A., Darcel, I., Davies, E., Desjardin, L., Dhingra, S., Ducas, J., Ervin, F. L., Fortin, C., Fowlis, R., Fulop, J., Furey, M., Gagnon, S., Gebhardt, V., Giannaccro, P., Gosselin, G., Graham, J., Grondin, F., Heath, J. W., Henderson, M., Hilton, D. R., Hiscock, J., Hui, W., Kaza, L., Kesselman, T., Kouz, S., Kucerak, M., Lahoude, N., Lamothe, M., Lebouthillier, P., Lenis, J., Levesque, P., Lopez, J. F., Lubelsky, B., Macritchie, D., Mayer, J. -P., Mcdowell, J. D., Montigny, M., Orestien-Lyall, T., Parekh, P., Pistawka, K., Price, J. B., Pruneau, G., Quinn, B., Reid, B. R., Richmond, M., Rose, B., Schuld, R., Sharma, N. K., Shetty, P., Stanton, E., Strauss, H. D., Sussex, B., Theroux, P., Turabian, M., Turner, C., Vizel, S., Walker, M., Weeks, A., Winkler, L., Zacharias, G., Zimmerman, R., Bartolucci, J., Castro, P., Diaz, M. A., Illanes, G., Potthoff, S., Sanchez, E. C., Silva, L. M., Yovanovich, J., Zanetti, F. L., Alan, D., Balázová, K., Boček, P., Cerny, J., Fischerova, B., Holub, M., Hradec, J., Janota, T., Janský, P., Kasper, J., Klimsa, Z., Motovská, Z., Pleva, L., Pluhacek, L., Pšenčka, M., Semrád, B., Spinar, J., Staněk, V., Štípal, R., Suítil, P., Vítovec, J., Wichterie, D., Widimský, P., Zeman, K., Andersen, C. B., Kriegbaum, J., Nielsen, N., Nielsen, P. E., Schou, J. B., Teesalu, R., Voitk, J., Haapamäki, H. V. H., Halkosaari, M., Härkönen, M., Jägerholm, S., Kärjä-Koskenkari, P., Karthunen, P., Kesäniemi, Y. A., Koskivirta, H., Lehto, P., Lilja, M., Paakkinen, S., Palomäki, A. K., Pietilä, K., Tuominen, J., Viopio-Pulkki, L., Ylönen, H., Adi, I., Admant, P., Akadirik, A., Alagha, Z., Alhabaj, S., Amat, G., Andre, A. A., Apffel, F., Aswad, K., Baradat, G., Bareiss, P., Barthers, F. B., Baudet, M., Baudouy, M., Bearez, E. M., Berthou, J. D., Berzin, B., Bessede, G., Blanc, J. J., Bocara, A., Bonneau, A., Bourdad, C., Bouvier, J. 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E., Pruvost, A., Quiret, J. C., Richard, C., Richard, P., Rickaud, P., Riehl-Aleil, V., Rifai, A., Rocher, R., Rotreff, P., Segrestin, B., Slama, M. S., Sultan, P., Tabone, X., Talbodec, A., Tissot, M. T., Toussaint, C., Veyrat, A., Zerrouk, Z., Adamczak, M., Altmann, E., Altybernd, B., Andreassen, G., Andresen, D., Appenrodt, H., Bachmann, S., Bäcker, U., Beckert, U., Behr, H. M., Beier, W., Beier, T., Berger, D., Bernsmeier, R., Beythien, R. D., Biechl, E., Biedermann, G., Bischoff, K. O., Blerich, J., Boch, H. B., Bonzel, T., Both, A. R., Breidenbach, K., Breuer, M., Breuer, H. W. M., Brunkhorst, F. B., Bruns, A., Bundschu, H. D., Burkhardt, W., Busse, H. J., Caesar, K., Cailloud, J., Chlosta, A., Chorlanopoulos, E., Consemüller, S., Decker, W., Dichgans, M., Dick, R., Diederich, K. W., Dienst, C., Dietz, A., Dißmann, R., Ditter, H., Doering, W., Drost, H., Dundalek, E. D., Eckardt, D., Edelmann, A., Eggeling, T., Eggert, G., Eichner, R., Endres, C., Engberding, R., Engel, H. 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- Subjects
Male ,Risk ,Infusions ,medicine.medical_treatment ,Myocardial Infarction ,Bolus lytic therapy ,Acute myocardial infarction ,Tissue plasminogen activator ,Thrombolytic drug ,Double-Blind Method ,Fibrinolytic Agents ,medicine ,Humans ,Thrombolytic Therapy ,Myocardial infarction ,Infusions, Intravenous ,Stroke ,Aged ,business.industry ,ST elevation ,Lanoteplase ,Emergency department ,Middle Aged ,medicine.disease ,Survival Analysis ,Regimen ,Relative risk ,Anesthesia ,Tissue Plasminogen Activator ,Female ,Intracranial Hemorrhages ,Cardiology and Cardiovascular Medicine ,business ,Intravenous ,medicine.drug - Abstract
AIMS To compare the efficacy and safety of lanoteplase, a single-bolus thrombolytic drug derived from alteplase tissue plasminogen activator, with the established accelerated alteplase regimen in patients presenting within 6 h of onset of ST elevation acute myocardial infarction. METHODS AND RESULTS 15,078 patients were recruited from 855 hospitals worldwide and randomized in a 2:1 ratio to receive either lanoteplase 120 KU. kg(-1)as a single intravenous bolus, or up to 100 mg accelerated alteplase given over 90 min. The primary end-point was all-cause mortality at 30 days and the hypothesis was that the two treatments would be equivalent. By 30 days, 6.61% of alteplase-treated patients and 6.75% lanoteplase-treated patients had died (relative risk 1.02). Total stroke occurred in 1.53% alteplase- and 1.87% lanoteplase-treated patients (ns); haemorrhagic stroke rates were 0.64% alteplase and 1.12% lanoteplase (P=0.004). The net clinical deficit of 30-day death or non-fatal disabling stroke was 7.0% and 7.2%, respectively. By 6 months, 8.8% of alteplase-treated patients and 8.7% of lanoteplase-treated patients had died. CONCLUSION Single-bolus weight-adjusted lanoteplase is an effective thrombolytic agent, equivalent to alteplase in terms of its impact on survival and with a comparable risk-benefit profile. The single-bolus regimen should shorten symptoms to treatment times and be especially convenient for emergency department or out-of-hospital administration.
- Published
- 2000
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