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132 results on '"Musumeci, Andrea"'

4. Congenital Lung Malformations: A Pictorial Review of Imaging Findings and a Practical Guide for Diagnosis

Author

Cancemi, Giovanna, primary, Distefano, Giulio, additional, Vitaliti, Gioele, additional, Milazzo, Dario, additional, Terzo, Giuseppe, additional, Belfiore, Giuseppe, additional, Di Benedetto, Vincenzo, additional, Scuderi, Maria Grazia, additional, Coronella, Maria, additional, Musumeci, Andrea Giovanni, additional, Grippaldi, Daniele, additional, Mauro, Letizia Antonella, additional, Foti, Pietro Valerio, additional, Basile, Antonio, additional, and Palmucci, Stefano, additional

Published
2024
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10. Defective Visceral Adipose Tissue Adaptation in Gestational Diabetes Mellitus.

Author

McElwain, Colm J, Manna, Samprikta, Musumeci, Andrea, Sylvester, Isaac, Rouchon, Chloé, O'Callaghan, Anne Marie, Ebad, Mustafa Abdalla Bakhit, McCarthy, Fergus P, and McCarthy, Cathal M

Subjects
GESTATIONAL diabetes, ADIPOSE tissues, INSULIN resistance
Abstract

Context Gestational diabetes mellitus (GDM) is a complex obstetric condition affecting localized glucose metabolism, resulting in systemic metabolic dysfunction. Objective This cross-sectional study aimed to explore visceral adipose tissue (VAT) as an integral contributor to GDM, focusing on elucidating the specific contribution of obesity and GDM pathology to maternal outcomes. Methods Fifty-six nulliparous pregnant women were recruited, including normal glucose tolerant (NGT) (n = 30) and GDM (n = 26) participants. Participants were subgrouped as nonobese (BMI <30 kg/m2) or obese (BMI ≥30 kg/m2). Metabolic markers in circulation, VAT, and placenta were determined. Morphological analysis of VAT and immunoblotting of the insulin signaling cascade were performed. Results GDM participants demonstrated hyperinsulinemia and elevated homeostatic model assessment for insulin resistance (HOMA-IR) scores relative to NGT participants. The GDM-obese subgroup had significant VAT adipocyte hypoplasia relative to NGT-nonobese tissue. GDM-obese VAT had significantly lower insulin receptor substrate (IRS)-2 expression, with elevated ser312 phosphorylation of IRS-1, relative to NGT-nonobese. GDM-obese participants had significantly elevated circulating leptin levels and placental adipsin secretion, while GDM-nonobese participants had elevated circulating adipsin levels with reduced placental adiponectin secretion. Conclusion These findings suggest that GDM-obese pregnancy is specifically characterized by inadequate VAT remodeling and dysfunctional molecular signaling, which contribute to insulin resistance and hinder metabolic health. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Postmortem Radiology and Digital Imaging

Author

Bertozzi, Giuseppe, primary, Pio Cafarelli, Francesco, additional, Giovanni Musumeci, Andrea, additional, Zizzo, Giulio, additional, Grilli, Giampaolo, additional, and Pomara, Cristoforo, additional

Published
2020
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19. Uveal melanoma: quantitative evaluation of diffusion-weighted MR imaging in the response assessment after proton-beam therapy, long-term follow-up

Author

Foti, Pietro Valerio, Longo, Antonio, Reibaldi, Michele, Russo, Andrea, Privitera, Giuseppe, Spatola, Corrado, Raffaele, Luigi, Salamone, Vincenzo, Farina, Renato, Palmucci, Stefano, Musumeci, Andrea, Caltabiano, Rosario, Ragusa, Marco, Mariotti, Cesare, Avitabile, Teresio, Milone, Pietro, and Ettorre, Giovanni Carlo

Published
2017
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29. Ly6D+Siglec-H+ precursors contribute to conventional dendritic cells via a Zbtb46+Ly6D+ intermediary stage.

Author

Lutz, Konstantin, Musumeci, Andrea, Sie, Christopher, Dursun, Ezgi, Winheim, Elena, Bagnoli, Johannes, Ziegenhain, Christoph, Rausch, Lisa, Bergen, Volker, Luecken, Malte D., Oostendorp, Robert A. J., Schraml, Barbara U., Theis, Fabian J., Enard, Wolfgang, Korn, Thomas, and Krug, Anne B.

Subjects
BONE marrow cells, CELL analysis, PROGENITOR cells, BONE marrow, CELL division, DENDRITIC cells
Abstract

Plasmacytoid and conventional dendritic cells (pDC and cDC) are generated from progenitor cells in the bone marrow and commitment to pDCs or cDC subtypes may occur in earlier and later progenitor stages. Cells within the CD11c+MHCII−/loSiglec-H+CCR9lo DC precursor fraction of the mouse bone marrow generate both pDCs and cDCs. Here we investigate the heterogeneity and commitment of subsets in this compartment by single-cell transcriptomics and high-dimensional flow cytometry combined with cell fate analysis: Within the CD11c+MHCII−/loSiglec-H+CCR9lo DC precursor pool cells expressing high levels of Ly6D and lacking expression of transcription factor Zbtb46 contain CCR9loB220hi immediate pDC precursors and CCR9loB220lo (lo-lo) cells which still generate pDCs and cDCs in vitro and in vivo under steady state conditions. cDC-primed cells within the Ly6DhiZbtb46– lo-lo precursors rapidly upregulate Zbtb46 and pass through a Zbtb46+Ly6D+ intermediate stage before acquiring cDC phenotype after cell division. Type I IFN stimulation limits cDC and promotes pDC output from this precursor fraction by arresting cDC-primed cells in the Zbtb46+Ly6D+ stage preventing their expansion and differentiation into cDCs. Modulation of pDC versus cDC output from precursors by external factors may allow for adaptation of DC subset composition at later differentiation stages. The ontogeny of conventional and plasmacytoid dendritic cells (DC) and how these two cell types are related is not fully known. Here the authors identify a pool of bone marrow precursor cells expressing Ly6D Siglec-H and Zbtb46 that can differentiate into either cDC or pDC and show that type I IFN can limit cDC and favor pDC output from these precursors. [ABSTRACT FROM AUTHOR]

Published
2022
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32. Proximal and distal radial artery approaches for endovascular percutaneous procedures: anatomical suitability by ultrasound evaluation

Author

Meo, Diego, primary, Falsaperla, Daniele, additional, Modica, Alessandro, additional, Calcagno, Maria Carla, additional, Libra, Federica, additional, Desiderio, Carla, additional, Palmucci, Stefano, additional, Foti, Pietro Valerio, additional, Musumeci, Andrea Giovanni, additional, and Basile, Antonio, additional

Published
2020
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34. NEW CORPORATE SOCIAL RESPONSIBILITY TOOL IN SOLID URBAN WASTE MANAGEMENT: CASE STUDY “DUSTY”.

Author

Torio, Alexia, Gambera, Vanessa, Musumeci, Andrea, Pezzino de Geronimo, Maria Rosa, and Coco, Antonio

Subjects
SOCIAL responsibility of business, WASTE management, SUSTAINABILITY, ECONOMIC activity, CORPORATE welfare
Abstract

Nowadays, companies are increasingly oriented towards the voluntary management of social variables in their business operations and in their relations with stakeholders. They are increasingly aware of the fact that social responsibility has a direct economic value in terms of strategic investment within the framework of their value proposition. For companies, the commitment to communicate the attitude to sustainability consists in measuring and communicating the assumption of responsibility. To effectively demonstrate and measure the company's commitment, constant quantifications and monitoring of indicators are necessary, including those related to issues on health and safety, working conditions, corporate welfare, environmental performance and social and economic activities. The objective of the paper is the application of the Corporate Social Responsibility principles of the case study company, in order to quantify the indicators of social accountability, enhance the path of social reporting. [ABSTRACT FROM AUTHOR]

Published
2020

35. Transkriptionelle Regulation der Differenzierung plasmazytoider dendritischer Zellen

Author

Musumeci, Andrea, Krug, Anne (Prof. Dr.), Korn, Thomas (Prof. Dr.), and Rad, Roland (Prof. Dr.)

Subjects
Medizin und Gesundheit, ddc:610
Abstract

This project employs total mRNA sequencing to define the transcriptional networks that control murine plasmacytoid dendritic cell (pDC) differentiation. A member of the Fox familiy of transcription factors was identified as a novel putative regulator of DC differentiation, which was further investigated in vitro using a loss of function approach. In addition, toll-like receptor stimulation triggered a pDC specific activation program in precursors and accelerated their differentiation. In diesem Projekt wird mittels mRNA-Sequenzierung das transkriptionelle Netzwerk der Differenzierung muriner plasmazytoider dendritischer Zellen (pDZ) definiert. Ein Mitglied der Fox-Familie wurde als potentieller Regulator der DZ Differenzierung identifiziert und mithife einer Knockout-Zellinie weiter untersucht. Weitere Ergebnisse zeigen, dass Toll-like-Rezeptor-Stimulation in Vorläuferzellen ein pDZ-spezifisches Aktivierungsprogramm auslöst und die Differenzierung in pDZ beschleunigt.

Published
2018

39. The transcriptional landscape of plasmacytoid dendritic cell differentiation

Author

Korn, Thomas (Prof. Dr.), Krug, Anne (Prof. Dr.), Rad, Roland (Prof. Dr.), Musumeci, Andrea, Korn, Thomas (Prof. Dr.), Krug, Anne (Prof. Dr.), Rad, Roland (Prof. Dr.), and Musumeci, Andrea

Abstract

This project employs total mRNA sequencing to define the transcriptional networks that control murine plasmacytoid dendritic cell (pDC) differentiation. A member of the Fox familiy of transcription factors was identified as a novel putative regulator of DC differentiation, which was further investigated in vitro using a loss of function approach. In addition, toll-like receptor stimulation triggered a pDC specific activation program in precursors and accelerated their differentiation., In diesem Projekt wird mittels mRNA-Sequenzierung das transkriptionelle Netzwerk der Differenzierung muriner plasmazytoider dendritischer Zellen (pDZ) definiert. Ein Mitglied der Fox-Familie wurde als potentieller Regulator der DZ Differenzierung identifiziert und mithife einer Knockout-Zellinie weiter untersucht. Weitere Ergebnisse zeigen, dass Toll-like-Rezeptor-Stimulation in Vorläuferzellen ein pDZ-spezifisches Aktivierungsprogramm auslöst und die Differenzierung in pDZ beschleunigt.

Published
2018

40. The transcriptional landscape of plasmacytoid dendritic cell differentiation

Author

Krug, Anne (Prof. Dr.), Korn, Thomas (Prof. Dr.);Rad, Roland (Prof. Dr.), Musumeci, Andrea, Krug, Anne (Prof. Dr.), Korn, Thomas (Prof. Dr.);Rad, Roland (Prof. Dr.), and Musumeci, Andrea

Abstract

This project employs total mRNA sequencing to define the transcriptional networks that control murine plasmacytoid dendritic cell (pDC) differentiation. A member of the Fox familiy of transcription factors was identified as a novel putative regulator of DC differentiation, which was further investigated in vitro using a loss of function approach. In addition, toll-like receptor stimulation triggered a pDC specific activation program in precursors and accelerated their differentiation., In diesem Projekt wird mittels mRNA-Sequenzierung das transkriptionelle Netzwerk der Differenzierung muriner plasmazytoider dendritischer Zellen (pDZ) definiert. Ein Mitglied der Fox-Familie wurde als potentieller Regulator der DZ Differenzierung identifiziert und mithife einer Knockout-Zellinie weiter untersucht. Weitere Ergebnisse zeigen, dass Toll-like-Rezeptor-Stimulation in Vorläuferzellen ein pDZ-spezifisches Aktivierungsprogramm auslöst und die Differenzierung in pDZ beschleunigt.

Published
2018

49. Prevalence of anti-nuclear autoantibodies in subjects exposed to natural asbestiform fibers: a cross-sectional study.

Author

Ledda, Caterina, Caltabiano, Rosario, Loreto, Carla, Cinà, Diana, Senia, Paola, Musumeci, Andrea, Ricceri, Vincenzo, Pomara, Cristoforo, and Rapisarda, Venerando

Subjects
AUTOANTIBODIES, AUTOIMMUNE diseases, COMPUTED tomography, SPIROMETRY, IMMUNOFLUORESCENCE
Abstract

Fluoro-edenite (FE) is an asbestiform mineral fiber spotted in the lava rocks excavated from a stone quarry in Biancavilla (Italy). The derived material had been employed locally for building purposes. Previous studies found evidence that exposure to asbestos may induce autoimmunity, with frequency of anti-nuclear autoantibodies (ANA). The aim of this study was to explore the relationship between FE exposure and autoimmune responses in an exposed population. For the study, 60 subjects living in the area of Biancavilla and 60 subjects as control group were randomly invited to participate. A free medical check, including spirometry and a high-resolution computer tomography chest scan, was given to all participants. ANA were determined by indirect immunofluorescence. On medical check, no subject showed any sign and/or symptoms of illness. Prevalence for samples positive to ANA were 70% (n = 42) and 25% (n = 15), respectively, for exposed and non-exposed subjects (p < 0.05). The presence of pleural plaques (PP) was found in 21 (30%) of the exposed subjects and in 2 (3%) of the non-exposed participants. PP subjects were always ANAs positive. In conclusion, as already it was observed with exposure to asbestos fibers, levels of ANA seemed to significantly increase in subjects who had been exposed to FE. Furthermore, all subjects showing PP were also ANA-positive. This first finding in subjects exposed to FE should encourage researchers to further investigate associations between autoimmune unbalance and environmental exposure to asbestiform fibers. [ABSTRACT FROM AUTHOR]

Published
2018
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50. Continuous single cell imaging reveals sequential steps of plasmacytoid dendritic cell development from common dendritic cell progenitors

Author

Dursun, Ezgi, Endele, Max, Musumeci, Andrea, Failmezger, Henrik, Wang, Shu-Hung, Tresch, Achim, Schroeder, Timm, Krug, Anne B., Dursun, Ezgi, Endele, Max, Musumeci, Andrea, Failmezger, Henrik, Wang, Shu-Hung, Tresch, Achim, Schroeder, Timm, and Krug, Anne B.

Abstract

Functionally distinct plasmacytoid and conventional dendritic cells (pDC and cDC) shape innate and adaptive immunity. They are derived from common dendritic cell progenitors (CDPs) in the murine bone marrow, which give rise to CD11c(+) MHCII- precursors with early commitment to DC subpopulations. In this study, we dissect pDC development from CDP into an ordered sequence of differentiation events by monitoring the expression of CD11c, MHC class II, Siglec H and CCR9 in CDP cultures by continuous single cell imaging and tracking. Analysis of CDP genealogies revealed a stepwise differentiation of CDPs into pDCs in a part of the CDP colonies. This developmental pathway involved an early CD11c(+) SiglecH(-) pre-DC stage and a Siglec H+ CCR9(low) precursor stage, which was followed rapidly by upregulation of CCR9 indicating final pDC differentiation. In the majority of the remaining CDP pedigrees however the Siglec H+ CCR9(low) precursor state was maintained for several generations. Thus, although a fraction of CDPs transits through precursor stages rapidly to give rise to a first wave of pDCs, the majority of CDP progeny differentiate more slowly and give rise to longer lived precursor cells which are poised to differentiate on demand.

Published
2016

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