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1. Management of dyslipidaemia in patients with coronary heart disease: Results from the ESC-EORP EUROASPIRE V survey in 27 countries

Author: De Backer, G., Jankowski, P., Kotseva, K., Mirrakhimov, E., Reiner, Z., Rydén, L., Tokgözoğlu, L., Wood, D., De Bacquer, D., Abreu, A., Aguiar, C., Badariene, J., Bruthans, J., Castro Conde, A., Cifkova, R., Crowley, J., Davletov, K., Bacquer, D. De, De Smedt, D., De Sutter, J., Deckers, J.W., Dilic, M., Dolzhenko, M., Druais, H., Dzerve, V., Erglis, A., Fras, Z., Gaita, D., Gotcheva, N., Grobbee, D.E., Gyberg, V., Hasan Ali, H., Heuschmann, P., Hoes, A.W., Lalic, N., Lehto, S., Lovic, D., Maggioni, A.P., Mancas, S., Marques-Vidal, P., Mellbin, L., Miličić, D., Oganov, R., Pogosova, N., Reiner, Ž., Stagmo, M., Störk, S., Sundvall, J., Tsioufis, K., Vulic, D., Wood, D.A., Jennings, C., Adamska, A., Adamska, S., Tuomilehto, J., Schnell, O., Fiorucci, E., Glemot, M., Larras, F., Missiamenou, V., Maggioni, A., Taylor, C., Ferreira, T., Lemaitre, K., Raman, L., DeSmedt, D., Willems, A.M., De Pauw, M., Vervaet, P., Bollen, J., Dekimpe, E., Mommen, N., Van Genechten, G., Dendale, P., Bouvier, C.A., Chenu, P., Huyberechts, D., Persu, A., Begic, A., Durak Nalbantic, A., Dzubur, A., Hadzibegic, N., Iglica, A., Kapidjic, S., Osmanagic Bico, A., Resic, N., Sabanovic Bajramovic, N., Zvizdic, F., Kovacevic-Preradovic, T., Popovic-Pejicic, S., Djekic, D., Gnjatic, T., Knezevic, T., Kos, Lj, Stanetic, B., Topic, G., Georgiev, Borislav, Terziev, A., Vladimirov, G., Angelov, A., Kanazirev, B., Nikolaeva, S., Tonkova, D., Vetkova, M., Milicic, D., Bosnic, A., Dubravcic, M., Glavina, M., Mance, M., Pavasovic, S., Samardzic, J., Batinic, T., Crljenko, K., Delic-Brkljacic, D., Dula, K., Golubic, K., Klobucar, I., Kordic, K., Kos, N., Nedic, M., Olujic, D., Sedinic, V., Blazevic, T., Pasalic, A., Percic, M., Sikic, J., Cífková, R., Hašplová, K., Šulc, P., Wohlfahrt, P., Mayer, O., Jr., Cvíčela, M., Filipovský, J., Gelžinský, J., Hronová, M., Hasan-Ali, H., Bakery, S., Mosad, E., Hamed, H.B., Ibrahim, A., Elsharef, M.A., Kholef, E.F., Shehata, A., Youssef, M., Elhefny, E., Farid, H., Moustafa, T.M., Sobieh, M.S., Kabil, H., Abdelmordy, A., Kiljander, E., Kiljander, P., Koukkunen, H., Mustonen, J., Cremer, C., Frantz, S., Haupt, A., Hofmann, U., Ludwig, K., Melnyk, H., Noutsias, M., Karmann, W., Prondzinsky, R., Herdeg, C., Hövelborn, T., Daaboul, A., Geisler, T., Keller, T., Sauerbrunn, D., Walz-Ayed, M., Ertl, G., Leyh, R., Ehlert, T., Klocke, B., Krapp, J., Ludwig, T., Käs, J., Starke, C., Ungethüm, K., Wagner, M., Wiedmann, S., Tolis, P., Vogiatzi, G., Sanidas, E., Tsakalis, K., Kanakakis, J., Koutsoukis, A., Vasileiadis, K., Zarifis, J., Karvounis, C., Gibson, I., Houlihan, A., Kelly, C., O'Donnell, M., Bennati, M., Cosmi, F., Mariottoni, B., Morganti, M., Cherubini, A., Di Lenarda, A., Radini, D., Ramani, F., Francese, M.G., Gulizia, M.M., Pericone, D., Aigerim, K., Zholdin, B., Amirov, B., Assembekov, B., Chernokurova, E., Ibragimova, F., Kodasbayev, A., Markova, A., Asanbaev, A., Toktomamatov, U., Tursunbaev, M., Zakirov, U., Abilova, S., Arapova, R., Bektasheva, E., Esenbekova, J., Neronova, K., Baigaziev, K., Baitova, G., Zheenbekov, T., Andrejeva, T., Bajare, I., Kucika, G., Labuce, A., Putane, L., Stabulniece, M., Klavins, E., Sime, I., Gedvilaite, L., Pečiuraite, D., Sileikienė, V., Skiauteryte, E., Solovjova, S., Sidabraite, R., Briedis, K., Ceponiene, I., Jurenas, M., Kersulis, J., Martinkute, G., Vaitiekiene, A., Vasiljevaite, K., Veisaite, R., Plisienė, J., Šiurkaitė, V., Vaičiulis, Ž., Czarnecka, D., Kozieł, P., Podolec, P., Nessler, J., Gomuła, P., Mirek-Bryniarska, E., Bogacki, P., Wiśniewski, A., Pająk, A., Wolfshaut-Wolak, R., Bućko, J., Kamiński, K., Łapińska, M., Paniczko, M., Raczkowski, A., Sawicka, E., Stachurska, Z., Szpakowicz, M., Musiał, W., Dobrzycki, S., Bychowski, J., Kosior, D.A., Krzykwa, A., Setny, M., Rak, A., Gąsior, Z., Haberka, M., Szostak-Janiak, K., Finik, M., Liszka, J., Botelho, A., Cachulo, M., Sousa, J., Pais, A., Durazzo, A., Matos, D., Gouveia, R., Rodrigues, G., Strong, C., Guerreiro, R., Aguiar, J., Cruz, M., Daniel, P., Morais, L., Moreira, R., Rosa, S., Rodrigues, I., Selas, M., Apostu, A., Cosor, O., Gaita, L., Giurgiu, L., Hudrea, C., Maximov, D., Moldovan, B., Mosteoru, S., Pleava, R., Ionescu, M., Parepa, I., Arutyunov, A., Ausheva, A., Isakova, S., Karpova, A., Salbieva, A., Sokolova, O., Vasilevsky, A., Pozdnyakov, Y., Antropova, O., Borisova, L., Osipova, I., Aleksic, M., Crnokrak, B., Djokic, J., Hinic, S., Vukasin, T., Zdravkovic, M., Lalic, N.M., Jotic, A., Lalic, K., Lukic, L., Milicic, T., Macesic, M., Stanarcic Gajovic, J., Stoiljkovic, M., Djordjevic, D., Kostic, S., Tasic, I., Vukovic, A., Jug, B., Juhant, A., Krt, A., Kugonjič, U., Chipayo Gonzales, D., Gómez Barrado, J.J., Kounka, Z., Marcos Gómez, G., Mogollón Jiménez, M.V., Ortiz Cortés, C., Perez Espejo, P., Porras Ramos, Y., Colman, R., Delgado, J., Otero, E., Pérez, A., Fernández-Olmo, M.R., Torres-LLergo, J., Vasco, C., Barreñada, E., Botas, J., Campuzano, R., González, Y., Rodrigo, M., de Pablo, C., Velasco, E., Hernández, S., Lozano, C., González, P., Castro, A., Dalmau, R., Hernández, D., Irazusta, F.J., Vélez, A., Vindel, C., Gómez-Doblas, J.J., García Ruíz, V., Gómez, L., Gómez García, M, Jiménez-Navarro, M., Molina Ramos, A., Marzal, D., Martínez, G., Lavado, R., Vidal, A., Boström-Nilsson, V., Kjellström, B., Shahim, B., Smetana, S., Hansen, O., Stensgaard-Nake, E., Klijn, A.J., Mangus, T.J.P., Peters, R.J.G., Scholte op Reimer, W., Snaterse, M., Aydoğdu, S., Ç Erol, Otürk, S., Tulunay Kaya, C., Ahmetoğlu, Y., Ergene, O., Akdeniz, B., Çırgamış, D., Akkoyun H Kültürsay, S., Kayıkçıoğlu, M., Çatakoğlu, A.B., Çengel, A., Koçak, A.A., Ağırbaşlı, M.A., Açıksarı, G., Çekin, M.E., Kaya, E.B., Koçyiğit, D., Öngen, Z., Özmen, E., Sansoy, V., Kaya, A., Oktay, V., Temizhan, A., Ünal, S., İ Yakut, Kalkan, A.K., Bozkurt, E., Kasapkara, H.A., Faradzh, C., Hrubyak, L., Konoplianyk, L., Kozhuharyova, N., Lobach, L., Nesukai, V., Nudchenko, O., Simagina, T., Yakovenko, L., Azarenko, V., Potabashny, V., Bazylevych, A., Bazylevych, M., Kaminska, K., Panchenko, L., Shershnyova, O., Ovrakh, T., Serik, S., Kolesnik, T., Kosova, H., Hoye P Atkin, A., Fellowes, D., Lindsay, S., Atkinson, C., Kranilla, C., Vinod, M., Beerachee, Y., Bennett, C., Broome, M., Bwalya, A., Caygill, Lindsay, Dinning, L., Gillespie, A., Goodfellow, R., Guy, J., Idress, T., Mills, C., Morgan, C., Oustance, N., Singh, N., Yare, M., Jagoda, J.M., Bowyer, H., Christenssen, V., Groves, A., Jan, A., Riaz, A., Gill, M., Sewell, T.A., Gorog, D., Baker, M., De Sousa, P., Mazenenga, T., Porter, J., Haines, F., Peachey, T., Taaffe, J., Wells, K., Ripley, D.P., Forward, H., McKie, H., Pick, S.L., Thomas, H.E., Batin, P.D., Exley, D., Rank, T., Wright, J., Kardos, A., Sutherland, S.-B., Wren, L., Leeson, P., Barker, D., Moreby, B., Sawyer, J., Stirrup, J., Brunton, M., Brodison, A., Craig, J., Peters, S., Kaprielian, R., Bucaj, A., Mahay, K., Oblak, M., Gale, C., Pye, M., McGill, Y., Redfearn, H., Fearnley, M., De Backer, Guy, Jankowski, Piotr, Kotseva, Kornelia, Mirrakhimov, Erkin, Reiner, Željko, Rydén, Lars, Tokgözoğlu, Lale, Wood, David, and De Bacquer, Dirk
Published: 2019
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2. Room Temperature Operation of a Radiofrequency Diamond Magnetometer near the Shot Noise Limit

Author: Shin, Chang S., Avalos, Claudia E., Butler, Mark C., Trease, David R., Seltzer, Scott J., Mustonen, J. Peter, Kennedy, Daniel J., Acosta, Victor M., Budker, Dmitry, Pines, Alexander, and Bajaj, Vikram S.
Subjects: Physics - Instrumentation and Detectors, Condensed Matter - Materials Science, Physics - Chemical Physics
Abstract: We operate a nitrogen vacancy (NV-) diamond magnetometer at ambient temperatures and study the dependence of its bandwidth on experimental parameters including optical and microwave excitation powers. We introduce an analytical theory that yields an explicit formula for the response of an ensemble of NV- spins to an oscillating magnetic field, such as in NMR applications. We measure a detection bandwidth of 1.6 MHz and a sensitivity of 4.6 nT/Hz^(1/2), unprecedented in a detector with this active volume and close to the photon shot noise limit of our experiment., Comment: 4 pages; 4 figures; supporting information
Published: 2012
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3. Security of wired communication in embedded systems

Author: Mustonen, J. (Joona) and Mustonen, J. (Joona)
Abstract: The purpose of this thesis was to study the security of wired communication in embedded systems, particularly the security of the Inter-Integrated Circuit, alternatively known as I2C. The security was assessed by the system’s ability to notice fraudulent data inputs from an Arduino-based copy of a peripheral device. The results of the experiment indicate that forging a copy of a peripheral device is straightforward and plausible, which indicates that further research is needed to develop preventative measures. Especially since peripheral devices can be a potential attack vector for larger systems.Langallisen tiedonsiirron turvallisuus sulautetuissa järjestelmissä. Tiivistelmä. Tässä työssä tutkittiin langallisen tiedonsiirron turvallisuutta sulautetuissa järjestelmissä. Tiedonsiirtoprotokolla, jota käytettiin työssä, oli I2C. Turvallisuus arvioitiin järjestelmän kyvyllä erottaa valheelliset datan syötöt Arduino pohjaisesta oheislaitteen kopiosta. Tämän tutkimuksen tulokset osoittavat, että oheislaitteiden kopioiminen on suoraviivaista ja mahdollista, joka osoittaa lisätutkimuksen tarpeen aiheeseen liittyen. Erityisesti, koska laajemman järjestelmän oheislaitteet voivat olla mahdollinen hyökkäysvektori järjestelmään itse.
Published: 2023

4. Reporting of costs and economic impacts in randomized trials of de-implementation interventions for low-value care:a systematic scoping review

Author: Falkenbach, P. (Petra), Raudasoja, A. J. (Aleksi J.), Vernooij, R. W. (Robin W. M.), Mustonen, J. M. (Jussi M. J.), Agarwal, A. (Arnav), Aoki, Y. (Yoshitaka), Blanker, M. H. (Marco H.), Cartwright, R. (Rufus), Garcia-Perdomo, H. A. (Herney A.), Kilpeläinen, T. P. (Tuomas P.), Lainiala, O. (Olli), Lamberg, T. (Tiina), Nevalainen, O. P. (Olli P. O.), Raittio, E. (Eero), Richard, P. O. (Patrick O.), Violette, P. D. (Philippe D.), Tikkinen, K. A. (Kari A. O.), Sipilä, R. (Raija), Turpeinen, M. (Miia), Komulainen, J. (Jorma), Falkenbach, P. (Petra), Raudasoja, A. J. (Aleksi J.), Vernooij, R. W. (Robin W. M.), Mustonen, J. M. (Jussi M. J.), Agarwal, A. (Arnav), Aoki, Y. (Yoshitaka), Blanker, M. H. (Marco H.), Cartwright, R. (Rufus), Garcia-Perdomo, H. A. (Herney A.), Kilpeläinen, T. P. (Tuomas P.), Lainiala, O. (Olli), Lamberg, T. (Tiina), Nevalainen, O. P. (Olli P. O.), Raittio, E. (Eero), Richard, P. O. (Patrick O.), Violette, P. D. (Philippe D.), Tikkinen, K. A. (Kari A. O.), Sipilä, R. (Raija), Turpeinen, M. (Miia), and Komulainen, J. (Jorma)
Abstract: Background: De-implementation of low-value care can increase health care sustainability. We evaluated the reporting of direct costs of de-implementation and subsequent change (increase or decrease) in health care costs in randomized trials of de-implementation research. Methods: We searched MEDLINE and Scopus databases without any language restrictions up to May 2021. We conducted study screening and data extraction independently and in duplicate. We extracted information related to study characteristics, types and characteristics of interventions, de-implementation costs, and impacts on health care costs. We assessed risk of bias using a modified Cochrane risk-of-bias tool. Results: We screened 10,733 articles, with 227 studies meeting the inclusion criteria, of which 50 included information on direct cost of de-implementation or impact of de-implementation on health care costs. Studies were mostly conducted in North America (36%) or Europe (32%) and in the primary care context (70%). The most common practice of interest was reduction in the use of antibiotics or other medications (74%). Most studies used education strategies (meetings, materials) (64%). Studies used either a single strategy (52%) or were multifaceted (48%). Of the 227 eligible studies, 18 (8%) reported on direct costs of the used de-implementation strategy; of which, 13 reported total costs, and 12 reported per unit costs (7 reported both). The costs of de-implementation strategies varied considerably. Of the 227 eligible studies, 43 (19%) reported on impact of de-implementation on health care costs. Health care costs decreased in 27 studies (63%), increased in 2 (5%), and were unchanged in 14 (33%). Conclusion: De-implementation randomized controlled trials typically did not report direct costs of the de-implementation strategies (92%) or the impacts of de-implementation on health care costs (81%). Lack of cost information may limit the value of de-implementation trials to decision-maker
Published: 2023

5. The presence of intraperitoneal, retroperitoneal and pleural fluid in acute Puumala hantavirus infection

Author: Tervo, L., primary, Outinen, T., additional, Kiekara, T., additional, Tietäväinen, J., additional, Paakkala, A., additional, Pörsti, I., additional, Huhtala, H., additional, Mäkelä, S., additional, and Mustonen, J., additional
Published: 2022
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6. Localizing Fouling in Water-Filled Pipe with Laser-Induced Non-Axisymmetric Guided Waves

Author: Mustonen, J oonas, primary, Suorsa, Joonas, additional, Iablonskvi, Denys, additional, Klami, Arto, additional, Salmi, Ari, additional, and Hreggstrom, Edward, additional
Published: 2022
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7. FEM-based time-reversal technique for an ultrasonic cleaning application

Author: Tommiska, O., Mustonen, J., Moilanen, P., Rauhala, T., Gritsevich, M., Salmi, A., Hæggström, E., Tommiska, O., Mustonen, J., Moilanen, P., Rauhala, T., Gritsevich, M., Salmi, A., and Hæggström, E.
Abstract: Ultrasound provides a way to clean fouled pipes in industrial settings without interrupting the production. Ultrasonic clamp-on cleaners are used to clean pipes, but they typically cannot focus the cleaning power. This leads to insufficient cleaning results in cases where the fouling is localized to certain parts of the pipe. To solve this issue, we propose a finite-element method -based time-reversal (FEM-TR) technique for controlling the acoustic field produced by an ultrasonic clamp-on cleaner. We demonstrate by simulations and experimental validation that FEM-TR can be used to control the acoustic field in clamp-on cleaners featuring relatively few narrow-band and high-power transducers. The proposed method allows us to focus sound to arbitrary pre-selected locations inside the structure. © 2022 The Authors
Published: 2022

8. Randomized controlled trials in de-implementation research:a systematic scoping review

Author: Raudasoja, A. J. (Aleksi J.), Falkenbach, P. (Petra), Vernooij, R. W. (Robin W. M.), Mustonen, J. M. (Jussi M. J.), Agarwal, A. (Arnav), Aoki, Y. (Yoshitaka), Blanker, M. H. (Marco H.), Cartwright, R. (Rufus), Garcia-Perdomo, H. A. (Herney A.), Kilpeläinen, T. P. (Tuomas P.), Lainiala, O. (Olli), Lamberg, T. (Tiina), Nevalainen, O. P. (Olli P. O.), Raittio, E. (Eero), Richard, P. O. (Patrick O.), Violette, P. D. (Philippe D.), Komulainen, J. (Jorma), Sipilä, R. (Raija), Tikkinen, K. A. (Kari A. O.), Raudasoja, A. J. (Aleksi J.), Falkenbach, P. (Petra), Vernooij, R. W. (Robin W. M.), Mustonen, J. M. (Jussi M. J.), Agarwal, A. (Arnav), Aoki, Y. (Yoshitaka), Blanker, M. H. (Marco H.), Cartwright, R. (Rufus), Garcia-Perdomo, H. A. (Herney A.), Kilpeläinen, T. P. (Tuomas P.), Lainiala, O. (Olli), Lamberg, T. (Tiina), Nevalainen, O. P. (Olli P. O.), Raittio, E. (Eero), Richard, P. O. (Patrick O.), Violette, P. D. (Philippe D.), Komulainen, J. (Jorma), Sipilä, R. (Raija), and Tikkinen, K. A. (Kari A. O.)
Abstract: Background: Healthcare costs are rising, and a substantial proportion of medical care is of little value. De-implementation of low-value practices is important for improving overall health outcomes and reducing costs. We aimed to identify and synthesize randomized controlled trials (RCTs) on de-implementation interventions and to provide guidance to improve future research. Methods: MEDLINE and Scopus up to May 24, 2021, for individual and cluster RCTs comparing de-implementation interventions to usual care, another intervention, or placebo. We applied independent duplicate assessment of eligibility, study characteristics, outcomes, intervention categories, implementation theories, and risk of bias. Results: Of the 227 eligible trials, 145 (64%) were cluster randomized trials (median 24 clusters; median follow-up time 305 days), and 82 (36%) were individually randomized trials (median follow-up time 274 days). Of the trials, 118 (52%) were published after 2010, 149 (66%) were conducted in a primary care setting, 163 (72%) aimed to reduce the use of drug treatment, 194 (85%) measured the total volume of care, and 64 (28%) low-value care use as outcomes. Of the trials, 48 (21%) described a theoretical basis for the intervention, and 40 (18%) had the study tailored by context-specific factors. Of the de-implementation interventions, 193 (85%) were targeted at physicians, 115 (51%) tested educational sessions, and 152 (67%) multicomponent interventions. Missing data led to high risk of bias in 137 (60%) trials, followed by baseline imbalances in 99 (44%), and deficiencies in allocation concealment in 56 (25%). Conclusions: De-implementation trials were mainly conducted in primary care and typically aimed to reduce low-value drug treatments. Limitations of current de-implementation research may have led to unreliable effect estimates and decreased clinical applicability of studied de-implementation strategies. We identified potential research gaps, including de
Published: 2022

9. An extensive gastroenteritis outbreak after drinking-water contamination by sewage effluent, Finland

Author: LAINE, J., HUOVINEN, E., VIRTANEN, M. J., SNELLMAN, M., LUMIO, J., RUUTU, P., KUJANSUU, E., VUENTO, R., PITKÄNEN, T., MIETTINEN, I., HERRALA, J., LEPISTÖ, O., ANTONEN, J., HELENIUS, J., HÄNNINEN, M.-L., MAUNULA, L., MUSTONEN, J., and KUUSI, M.
Published: 2011
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10. Cross-Reactivity between Antibodies to Thyroid Microsomal Antigens and Myeloperoxidase

Author: Haapala, A. M., Hyöty, H., Soppi, E., Parkkonen, P., Mustonen, J., Pasternack, A., and Gross, Wolfgang L., editor
Published: 1993
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11. The presence of intraperitoneal, retroperitoneal and pleural fluid in acute Puumala hantavirus infection.

Author: Tervo, L., Outinen, T., Kiekara, T., Tietäväinen, J., Paakkala, A., Pörsti, I., Huhtala, H., Mäkelä, S., and Mustonen, J.
Subjects: HANTAVIRUS diseases, HEMORRHAGIC fever with renal syndrome, MAGNETIC resonance imaging, ACUTE kidney failure, PLEURAL effusions, CYSTATIN C
Abstract: Puumala hantavirus (PUUV) causes most cases of haemorrhagic fever with renal syndrome (HFRS) in Europe. PUUV infection is characterised by acute kidney injury, thrombocytopenia and increased capillary leakage. Typical symptoms are fever, headache, nausea, abdominal and back pain. This study aimed to evaluate the amount and distribution of intraperitoneal, retroperitoneal and pleural fluid and the association of fluid collections to the symptoms and clinical findings in patients with acute PUUV infection. Abdominal magnetic resonance imaging (MRI) was performed on 27 hospitalised patients with acute PUUV infection. The clinical and laboratory findings and patients' symptoms were analysed in relation to the imaging findings. The thickness of the fluid collections was measured in millimetres (mm) from axial images. Fluid collections were found in all patients. The amount of intraperitoneal fluid correlated positively with plasma C-reactive protein (CRP) level (r = 0.586, p =.001), while it had an inverse correlation with serum creatinine concentration (r = −0.418, p =.030). Retroperitoneal fluid also correlated inversely with serum creatinine and cystatin C concentrations (r = −0.501, p =.008 and r = −0.383, p =.048, respectively). The amount of fluid was not greater in patients with abdominal or back pain. Patients with back pain had higher serum creatinine compared with patients without back pain, 452 µmol/L (range 88–1071) vs. 83 µmol/L (range 60–679), p =.004. Fluid collections were found in all patients. A greater amount of intraperitoneal fluid associates with higher CRP concentrations but not with higher serum creatinine levels. Back pain associates with higher creatinine level but not with the presence of fluids. [ABSTRACT FROM AUTHOR]
Published: 2023
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12. Saanko leikkiä saamelaisuudella?:saamelaisen pelisuunnittelun haasteet, mahdollisuudet ja käytännön kysymykset

Author: Mustonen, J. (Janne)
Abstract: Tiivistelmä. Tämä tutkielma on saamelaisen kulttuurin oppiaineen opinnäytetyö. Sen tarkoitus on tarkastella saamelaista pelisuunnittelua pelisuunnittelijan näkökulmasta sekä käsitellä saamelaisuuden pelillistämiseen liittyviä haasteita, mahdollisuuksia ja käytännön kysymyksiä. Tutkimuksen taustalla ovat kysymykset popularisoinnista ja tiedon lisäämisestä saamelaisuudesta. Valtaväestöillä on usein puutteelliset tiedot saamelaisesta kulttuurista ja saamelaisuuteen liittyvien kysymysten taustoista. Tietovaje puolestaan on omiaan kontribuoimaan saamelaisuuteen liittyviä yhteiskunnallisia ongelmia. Tutkielmassa ehdotan saamelaista pelisuunnittelua yhdeksi tavaksi lisätä — tai pikemminkin yleistajuistaa jo olemassa olevaa — tietoa saamelaisuudesta. Popularisoivia saamelaisteemaisia pelejä on toistaiseksi vähän. Tämän vuoksi olen itse työstänyt oman saamelaisteemaisen peliprojektin Giehtaruohttasa Boazokeaisárin — jota analysoin tässä opinnäytetyössä jo olemassa olevien saamelaisteemaisten pelien ohella. Hyödynnän aineistonani myös haastatteluja. Haastateltavia ovat Gieku ry:n jäsenet, Käsivarren poronhoidon parissa työskentelevät ihmiset ja Saamelaiskäräjien Nuorisoneuvosto 2018–2020 Dihtosis-hankkeineen. Haastateltavilta kysyn näkemyksiä saamelaisuuden pelillistämisestä ja tiedottamisesta sekä heille tärkeistä asioista. Tutkielmani osoittaa konsultoinnin ja osallistamisen saamelaisen pelisuunnittelun ydinmenetelmiksi. Lisäksi saamelaiseen pelisuunnitteluun liittyvät kysymykset kulttuurisesta omimisesta. Popularisoivien pelien tapauksessa haasteina saamelaisessa pelisuunnittelussa ovat myös kohdeyleisön rajaus ja rahallinen hyötyminen pelistä. Tämä tutkielma tuloksineen on pioneerityö saamelaisessa pelitutkimuksessa, sillä aiempaa tutkimusta aiheesta on tehnyt vain Outi Laiti pro gradu -työssään (2016). Tämän pohjana olivat digitaaliset pelit, kun taas omani keskiössä ovat fyysiset pelit, kuten lauta- ja korttipelit. Tutkielmani luo osaltaan pohjaa tulevaisuuden saamelaiselle pelitutkimukselle.Abstract. This is a master’s thesis of sámi culture. The thesis aims to examine sámi game designing from game developers point of view and to address challenges, opportunities and practical issues around sámi game designing. The thesis is connected to the issues regarding the popularization of indigenous studies and to questions how to raise public awareness of indigenous knowledge. In Finland, the lack of awareness of sámi culture and sámi history for one’s part is often contributing to societal tensions regarding sámi issues. In this thesis I am suggesting sámi game designing as a one method of raising awareness of sámi culture. So far, there are still few games representing sámi people. This is the main reason I have joined sámi game designing myself and developed my own sámi game project called Giehtaruohttasa Boazokeaisár — The Reindeer Emperor of Enontekiö area. In my thesis, I am analyzing this game project of mine along with other already existing sámi game projects. I have also interviewed different people and stakeholders in this thesis. The stakeholders are: 1) members of Gieku ry — a sámi student organization of University of Oulu. 2) People working with or around reindeer herding in Enontekiö municipality, Finland. 3) Youth council of Finnish Sámi parliament. 4) Project worker of Dihtosis project of Sámi Youth council and Nuorten Akatemia. The interviewees discussed about sámi game designing and about other issues they considered important. This thesis points out the importance of participation and consultation in sámi game designing. It also highlights the issues regarding cultural appropriation in sámi game designing. In case of popularizing games, one of the main challenge in sámi game designing is how to limit the games target audience and how to gain monetary benefits from the game in financial and ethical sense. This thesis along with its results is one of the pioneering works of sámi game research. There are no earlier research with such topics, except Outi Laiti’s másters thesis (2016). Laiti’s topic however, concentrated on digital games whereas mine is focused on physical games such as board- and card games.
Published: 2021

13. FEM-Based Time-Reversal Enhanced Ultrasonic Cleaning

Author: Mustonen, J., Tommiska, O., Holmström, A., Rauhala, T., Moilanen, P., Gritsevich, M., Salmi, A., Hæggström, E., Mustonen, J., Tommiska, O., Holmström, A., Rauhala, T., Moilanen, P., Gritsevich, M., Salmi, A., and Hæggström, E.
Abstract: Pipe fouling is a challenging problem in many industrial applications. Current cleaning techniques require halting the production during the cleaning phase and the existing methods are unable to do targeted cleaning, even though fouling is often localized to certain areas inside the pipeline. To address this issue, we use FEM-simulated, time-reversed signals to focus ultrasound power onto a pre-determined location: a fouled pipe residing inside a Plexiglas container. Ultrasound cleaning with similar acoustic power was compared to the time-reversal enhanced method in terms of cleaning efficiency. The cleaning efficiency was determined by measuring how much fouling, by mass, both protocols removed from the surface of a Plexiglas pipe, using similar input electric power and equal cleaning time. Our results indicate that the proposed time-reversal-based technique removes three times more fouling than the standard ultrasound cleaning without focusing. The study extends our previous paper on FEM-based time-reversal focusing [1]. © 2021.
Published: 2021

14. Risk factors for major adverse cardiovascular events after the first acute coronary syndrome

Author: Okkonen, M. (Marjo), Havulinna, A. S. (Aki S.), Ukkola, O. (Olavi), Huikuri, H. (Heikki), Pietilä, A. (Arto), Koukkunen, H. (Heli), Lehto, S. (Seppo), Mustonen, J. (Juha), Ketonen, M. (Matti), Airaksinen, J. (Juhani), Kesäniemi, Y. A. (Y. Antero), Salomaa, V. (Veikko), Okkonen, M. (Marjo), Havulinna, A. S. (Aki S.), Ukkola, O. (Olavi), Huikuri, H. (Heikki), Pietilä, A. (Arto), Koukkunen, H. (Heli), Lehto, S. (Seppo), Mustonen, J. (Juha), Ketonen, M. (Matti), Airaksinen, J. (Juhani), Kesäniemi, Y. A. (Y. Antero), and Salomaa, V. (Veikko)
Abstract: Aims: To evaluate risk factors for major adverse cardiac event (MACE) after the first acute coronary syndrome (ACS) and to examine the prevalence of risk factors in post-ACS patients. Methods: We used Finnish population-based myocardial infarction register, FINAMI, data from years 1993–2011 to identify survivors of first ACS (n = 12686), who were then followed up for recurrent events and all-cause mortality for three years. Finnish FINRISK risk factor surveys were used to determine the prevalence of risk factors (smoking, hyperlipidaemia, diabetes and blood pressure) in post-ACS patients (n = 199). Results: Of the first ACS survivors, 48.4% had MACE within three years of their primary event, 17.0% were fatal. Diabetes (p = 4.4 × 10−7), heart failure (HF) during the first ACS attack hospitalization (p = 6.8 × 10−15), higher Charlson index (p = 1.56 × 10−19) and older age (p = .026) were associated with elevated risk for MACE in the three-year follow-up, and revascularization (p = .0036) was associated with reduced risk. Risk factor analyses showed that 23% of ACS survivors continued smoking and cholesterol levels were still high (>5mmol/l) in 24% although 86% of the patients were taking lipid lowering medication. Conclusion: Diabetes, higher Charlson index and HF are the most important risk factors of MACE after the first ACS. Cardiovascular risk factor levels were still high among survivors of first ACS.
Published: 2021

15. High pentraxin-3 plasma levels associate with thrombocytopenia in acute Puumala hantavirus-induced nephropathia epidemica

Author: Outinen, T. K., Mäkelä, S., Huhtala, H., Hurme, M., Meri, S., Pörsti, I., Sane, J., Vaheri, A., Syrjänen, J., and Mustonen, J.
Published: 2012
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16. Long-term prognosis after coronary artery bypass surgery

Author: Ketonen, M., Pajunen, P., Koukkunen, H., Immonen-Räihä, P., Mustonen, J., Mähönen, M., Niemelä, M., Kuulasmaa, K., Palomäki, P., Arstila, M., Vuorenmaa, T., Lehtonen, A., Lehto, S., Miettinen, H., Torppa, J., Tuomilehto, J., Airaksinen, J., Pyörälä, K., and Salomaa, V.
Published: 2008
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17. Hormonal deficiencies during and after Puumala hantavirus infection

Author: Mäkelä, S., Jaatinen, P., Miettinen, M., Salmi, J., Ala-Houhala, I., Huhtala, H., Hurme, M., Pörsti, I., Vaheri, A., and Mustonen, J.
Published: 2010
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18. Urine soluble urokinase-type plasminogen activator receptor levels correlate with proteinuria in Puumala hantavirus infection

Author: Outinen, T. K., Mäkelä, S., Huttunen, R., Mäenpää, N., Libraty, D., Vaheri, A., Mustonen, J., and Aittoniemi, J.
Published: 2014
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19. Prognosis of clinical renal disease and incidence of new renal findings in patients with rheumatoid arthritis: follow-up of a population-based study

Author: Karstila, K., Korpela, M., Sihvonen, S., and Mustonen, J.
Published: 2007
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20. Influence of intraspecific relationships on the allocation of temporal resources in the lekking ruff, Calidris pugnax

Author: Mustonen, J. (Jaani)
Abstract: Alternative Reproductive Tactics (ARTs) are utilized by animals of both sex to optimize their reproductive success in an intrasexually competitive environment where they are unable to prevail through use of the predominant tactic for obtaining mates. Often manifested as subtle differences in physical size, species where distinct genetically fixed morphological differences are associated with specific tactics are rare. The ruff (Calidris pugnax), a lekking palearctic wader, exhibits three fixed morphs (territorial and combative “independents”, cooperative and non-aggressive “satellites” and the female mimicking “faeders”) with distinct morphologies and reproductive behaviours which have their reproductive success interwoven to one-another on the leks. This diversity creates intricate connections between the morphs and sexes, giving rise to a web of influential relationships that have not been investigated thoroughly. These relationships were explored through utilization of stand-alone cameras to obtain precise information on the time use and reproductive success of male morphs and females and the evolution of their time investment throughout the lekking season. The degree of influence morphs and sexes exerted on the allocation of temporal resources by others through their own corresponding time investment was particularly investigated. The gradual progress of the female receptivity eventually resulting in a rapid copulatory peak was described, as well as and the central role of the time investment by dominant males on the attractiveness of a lek, both to females and other males alike. Indications of a more complex role of the satellite males in the overall success of a lek were identified, suggesting of even greater intricacy in the connections between the morphs.
Published: 2020

21. Myocardial infarction in diabetic and non-diabetic persons with and without prior myocardial infarction: the FINAMI Study

Author: Pajunen, P., Koukkunen, H., Ketonen, M., Jerkkola, T., Immonen-Räihä, P., Kärjä-Koskenkari, P., Kuulasmaa, K., Palomäki, P., Mustonen, J., Lehtonen, A., Arstila, M., Vuorenmaa, T., Lehto, S., Miettinen, H., Torppa, J., Tuomilehto, J., Kesäniemi, Y. A., Pyörälä, K., and Salomaa, V.
Published: 2005
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22. Renal MRI findings and their clinical associations in nephropathia epidemica: analysis of quantitative findings

Author: Paakkala, A., Dastidar, P., Ryymin, P., Huhtala, H., and Mustonen, J.
Published: 2005
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23. Hyperpolarized Xenon Magnetic Resonance Imaging of Combustion Processes

Author: Mustonen, J. Peter
Subjects: Physical chemistry, Combustion, Magnetic Resonance Imaging, MRI, NMR, Nuclear Magnetic Resonance, Xenon
Abstract: There is considerable interest in new methods to probe the chemistry and thermodynamics of enclosed combustion processes. Hyperpolarized xenon gas magnetic resonance imaging enables sensitive and noninvasive analysis of chemical composition and velocity within enclosed and opaque samples. By taking advantage of both the temperature sensitivity of the chemical shift as well as the inertness of xenon-129, temperature and velocity distribution images of an enclosed flame can be acquired. Previous attempts to analyze high-temperature combustion reactions using nuclear magnetic resonance employed two-dimensional exchange spectroscopy of hyperpolarized xenon and proton single-point imaging. In the present study, a homebuilt, water-cooled probe was fabricated, including electronics that are able to withstand high temperatures (approaching 2000 K). Hyperpolarized xenon is premixed with a combustible gas (methane or dimethyl ether) and meets with pure oxygen at an enclosed diffusion flame centered within a 15-mm (diameter) by 25.4-mm (height) insulated coil. A spin echo pulse sequence with velocity and acceleration compensated phase-encodes, is used to generate temperature-weighted, three-dimensional chemical shift images as well as velocity maps of the flame region. This technique can be applied to studying confined combustion processes such as microturbine engines on microelectromechanical systems devices.
Published: 2012

24. Glomerular filtration rate and parathyroid hormone are associated with 1,25-dihydroxyvitamin D in men without chronic kidney disease

Author: Karhapää, P., Pihlajamäki, J., Pörsti, I., Kastarinen, M., Mustonen, J., Niemelä, O., Tuomi, H., and Kuusisto, J.
Published: 2012
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25. Severe crescentic glomerulonephritis linked to an acute Hantaan virus infection?

Author: Clement, Jan, Mustonen, J., Van Damme, B., Helin, H., Maes, P., and Van Ranst, M.
Published: 2011
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26. The effects of pre- and post-pregnancy inflammatory bowel disease diagnosis on birth outcomes

Author: Raatikainen, K., Mustonen, J., Pajala, M. O., Heikkinen, M., and Heinonen, S.
Published: 2011
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27. Primary aldosteronism: Higher volume load, cardiac output and arterial stiffness than in essential hypertension

Author: Choudhary, M. K., primary, Värri, E., additional, Matikainen, N., additional, Koskela, J., additional, Tikkakoski, A. J., additional, Kähönen, M., additional, Niemelä, O., additional, Mustonen, J., additional, Nevalainen, P. I., additional, and Pörsti, I., additional
Published: 2020
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28. Diverse associations of 25-hydroxyvitamin D and 1,25-dihydroxy-vitamin D with dyslipidaemias

Author: Karhapää, P., Pihlajamäki, J., Pörsti, I., Kastarinen, M., Mustonen, J., Niemelä, O., and Kuusisto, J.
Published: 2010
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29. Management of dyslipidaemia in patients with coronary heart disease: Results from the ESC-EORP EUROASPIRE V survey in 27 countries

Author: De Backer, Guy Jankowski, Piotr Kotseva, Kornelia and Mirrakhimov, Erkin Reiner, Zeljko Ryden, Lars Tokgozoglu, Lale Wood, David De Bacquer, Dirk Abreu, A. Aguiar, C. and Badariene, J. Bruthans, J. Castro Conde, A. Cifkova, R. and Crowley, J. Davletov, K. De Smedt, D. De Sutter, J. and Deckers, J. W. Dilic, M. Dolzhenko, M. Druais, H. and Dzerve, V. Erglis, A. Fras, Z. Gaita, D. Gotcheva, N. and Grobbee, D. E. Gyberg, V. Ali, H. Hasan Heuschmann, P. and Hoes, A. W. Lalic, N. Lehto, S. Lovic, D. Maggioni, A. P. Mancas, S. Marques-Vidal, P. Mellbin, L. Milicic, D. Oganov, R. Pogosova, N. Stagmo, M. Stoerk, S. and Sundvall, J. Tsioufis, K. Vulic, D. Wood, D. A. and Jennings, C. Adamska, A. Adamska, S. Mellbin, L. and Tuomilehto, J. Schnell, O. Fiorucci, E. Glemot, M. and Larras, F. Missiamenou, V. Maggioni, A. Taylor, C. and Ferreira, T. Lemaitre, K. Raman, L. Sundvall, J. and DeSmedt, D. De Sutter, J. Willems, A. M. De Pauw, M. and Vervaet, P. Bollen, J. Dekimpe, E. Mommen, N. Van Genechten, G. Dendale, P. Bouvier, C. A. Chenu, P. and Huyberechts, D. Persu, A. Dilic, M. Begic, A. Nalbantic, A. Durak Dzubur, A. Hadzibegic, N. Iglica, A. Kapidjic, S. Bico, A. Osmanagic Resic, N. Bajramovic, N. Sabanovic and Zvizdic, F. Vulic, D. Kovacevic-Preradovic, T. and Popovic-Pejicic, S. Djekic, D. Gnjatic, T. Knezevic, T. and Kovacevic-Preradovic, T. Kos, Lj Popovic-Pejicic, S. and Stanetic, B. Topic, G. Gotcheva, N. Georgiev, Borislav and Terziev, A. Vladimirov, G. Angelov, A. Kanazirev, B. and Nikolaeva, S. Tonkova, D. Vetkova, M. Milicic, D. and Bosnic, A. Dubravcic, M. Glavina, M. Mance, M. and Pavasovic, S. Samardzic, J. Batinic, T. Crljenko, K. and Delic-Brkljacic, D. Dula, K. Golubic, K. Klobucar, I. and Kordic, K. Kos, N. Nedic, M. Olujic, D. Sedinic, V. and Blazevic, T. Pasalic, A. Percic, M. Sikic, J. Bruthans, J. Cifkova, R. Hasplova, K. Sulc, P. Wohlfahrt, P. and Mayer, Jr., O. Cvicela, M. Filipovsky, J. Gelzinsky, J. and Hronova, M. Hasan-Ali, H. Bakery, S. Mosad, E. Hamed, H. B. Ibrahim, A. Elsharef, M. A. Kholef, E. F. Shehata, A. and Youssef, M. Elhefny, E. Farid, H. Moustafa, T. M. and Sobieh, M. S. Kabil, H. Abdelmordy, A. Lehto, S. and Kiljander, E. Kiljander, P. Koukkunen, H. Mustonen, J. and Cremer, C. Frantz, S. Haupt, A. Hofmann, U. Ludwig, K. and Melnyk, H. Noutsias, M. Karmann, W. Prondzinsky, R. and Herdeg, C. Hoevelborn, T. Daaboul, A. Geisler, T. and Keller, T. Sauerbrunn, D. Walz-Ayed, M. Ertl, G. Leyh, R. Stoerk, S. Heuschmann, P. Ehlert, T. Klocke, B. and Krapp, J. Ludwig, T. Kaes, J. Starke, C. Ungethuem, K. and Wagner, M. Wiedmann, S. Tsioufis, K. Tolis, P. and Vogiatzi, G. Sanidas, E. Tsakalis, K. Kanakakis, J. and Koutsoukis, A. Vasileiadis, K. Zarifis, J. Karvounis, C. and Crowley, J. Gibson, I. Houlihan, A. Kelly, C. O'Donnell, M. Bennati, M. Cosmi, F. Mariottoni, B. Morganti, M. and Cherubini, A. Di Lenarda, A. Radini, D. Ramani, F. and Francese, M. G. Gulizia, M. M. Pericone, D. Davletov, K. and Aigerim, K. Bekbolat, Z. Amirov, B. Assembekov, B. and Chernokurova, E. Ibragimova, F. Kodasbayev, A. Markova, A. and Asanbaev, A. Toktomamatov, U. Tursunbaev, M. Zakirov, U. and Abilova, S. Arapova, R. Bektasheva, E. Esenbekova, J. and Neronova, K. Asanbaev, A. Baigaziev, K. Toktomamatov, U. and Zakirov, U. Baitova, G. Zheenbekov, T. Erglis, A. and Andrejeva, T. Bajare, I. Kucika, G. Labuce, A. Putane, L. Stabulniece, M. Dzerve, V. Klavins, E. Sime, I. and Badariene, J. Gedvilaite, L. Peciuraite, D. Sileikiene, V. and Skiauteryte, E. Solovjova, S. Sidabraite, R. Briedis, K. and Ceponiene, I. Jurenas, M. Kersulis, J. Martinkute, G. and Vaitiekiene, A. Vasiljevaite, K. Veisaite, R. Plisiene, J. Siurkaite, V. Vaiciulis, Z. Czarnecka, D. Koziel, P. and Podolec, P. Nessler, J. Gomula, P. Mirek-Bryniarska, E. and Bogacki, P. Wisniewski, A. Pajak, A. Wolfshaut-Wolak, R. and Bucko, J. Kaminski, K. Lapinska, M. Paniczko, M. and Raczkowski, A. Sawicka, E. Stachurska, Z. Szpakowicz, M. and Musial, W. Dobrzycki, S. Bychowski, J. Kosior, D. A. and Krzykwa, A. Setny, M. Kosior, D. A. Rak, A. Gasior, Z. and Haberka, M. Gasior, Z. Haberka, M. Szostak-Janiak, K. and Finik, M. Liszka, J. Botelho, A. Cachulo, M. Sousa, J. Pais, A. Aguiar, C. Durazzo, A. Matos, D. and Gouveia, R. Rodrigues, G. Strong, C. Guerreiro, R. and Aguiar, J. Abreu, A. Cruz, M. Daniel, P. Morais, L. and Moreira, R. Rosa, S. Rodrigues, I. Selas, M. Gaita, D. and Mancas, S. Apostu, A. Cosor, O. Gaita, L. Giurgiu, L. Hudrea, C. Maximov, D. Moldovan, B. Mosteoru, S. and Pleava, R. Ionescu, M. Parepa, I. Pogosova, N. and Arutyunov, A. Ausheva, A. Isakova, S. Karpova, A. and Salbieva, A. Sokolova, O. Vasilevsky, A. Pozdnyakov, Y. and Antropova, O. Borisova, L. Osipova, I. Lovic, D. and Aleksic, M. Crnokrak, B. Djokic, J. Hinic, S. Vukasin, T. Zdravkovic, M. Lalic, N. M. Jotic, A. Lalic, K. and Lukic, L. Milicic, T. Macesic, M. Gajovic, J. Stanarcic and Stoiljkovic, M. Djordjevic, D. Kostic, S. Tasic, I. and Vukovic, A. Fras, Z. Jug, B. Juhant, A. Krt, A. and Kugonjic, U. Chipayo Gonzales, D. Gomez Barrado, J. J. and Kounka, Z. Marcos Gomez, G. Mogollon Jimenez, M. V. Ortiz Cortes, C. Perez Espejo, P. Porras Ramos, Y. Colman, R. and Delgado, J. Otero, E. Perez, A. Fernandez-Olmo, M. R. and Torres-LLergo, J. Vasco, C. Barrenada, E. Botas, J. and Campuzano, R. Gonzalez, Y. Rodrigo, M. de Pablo, C. and Velasco, E. Hernandez, S. Lozano, C. Gonzalez, P. and Castro, A. Dalmau, R. Hernandez, D. Irazusta, F. J. and Velez, A. Vindel, C. Gomez-Doblas, J. J. Garcia Ruiz, V. and Gomez, L. Gomez Garcia, M. Jimenez-Navarro, M. Molina Ramos, A. Marzal, D. Martinez, G. Lavado, R. Vidal, A. and Bostrom-Nilsson, V. Kjellstrom, B. Shahim, B. Smetana, S. and Hansen, O. Stensgaard-Nake, E. Deckers, J. W. Klijn, A. J. Mangus, T. J. P. Peters, R. J. G. Reimer, W. Scholte Op and Snaterse, M. Aydogdu, S. Erol, C. Oturk, S. Kaya, C. Tulunay Ahmetoglu, Y. Ergene, O. Akdeniz, B. Cirgamis, D. Kultursay, S. Akkoyun H. Kayikcioglu, M. Catakoglu, A. B. and Cengel, A. Kocak, A. A. Agirbasli, M. A. Aciksari, G. and Cekin, M. E. Kaya, E. B. Kocyigit, D. Ongen, Z. and Ozmen, E. Sansoy, V. Kaya, A. Oktay, V. Temizhan, A. and Unal, S. Yakut, I. Kalkan, A. K. Bozkurt, E. Kasapkara, H. A. Dolzhenko, M. Faradzh, C. Hrubyak, L. Konoplianyk, L. Kozhuharyova, N. Lobach, L. Nesukai, V. Nudchenko, O. and Simagina, T. Yakovenko, L. Azarenko, V. Potabashny, V. and Bazylevych, A. Bazylevych, M. Kaminska, K. Panchenko, L. and Shershnyova, O. Ovrakh, T. Serik, S. Kolesnik, T. and Kosova, H. Adamska, A. Adamska, S. Jennings, C. Atkin, A. Hoye P. Fellowes, D. Lindsay, S. Atkinson, C. and Kranilla, C. Vinod, M. Beerachee, Y. Bennett, C. Broome, M. Bwalya, A. Caygill, Lindsay Dinning, L. Gillespie, A. and Goodfellow, R. Guy, J. Idress, T. Mills, C. Morgan, C. Oustance, N. Singh, N. Yare, M. Jagoda, J. M. and Bowyer, H. Christenssen, V. Groves, A. Jan, A. Riaz, A. and Gill, M. Sewell, T. A. Gorog, D. Baker, M. De Sousa, P. Mazenenga, T. Porter, J. Haines, F. Peachey, T. and Taaffe, J. Wells, K. Ripley, D. P. Forward, H. McKie, H. and Pick, S. L. Thomas, H. E. Batin, P. D. Exley, D. and Rank, T. Wright, J. Kardos, A. Sutherland, S. -B. Wren, L. Leeson, P. Barker, D. Moreby, B. Sawyer, J. and Stirrup, J. Brunton, M. Brodison, A. Craig, J. Peters, S. Kaprielian, R. Bucaj, A. Mahay, K. Oblak, M. and Gale, C. Pye, M. McGill, Y. Redfearn, H. Fearnley, M. and EUROASPIRE V Collaborators Writing Comm Sci Steering Executive Comm Coordinating Ctr Diabet Ctr Data Management Ctr Stat Anal Ctr Cent Lab Study Ctr Org Investigators Other
Abstract: Background and aims: One of the objectives of the ESC-EORP EUROASPIRE V survey is to determine how well European guidelines on the management of dyslipidaemias are implemented in coronary patients. Methods: Standardized methods were used by trained technicians to collect information on 7824 patients from 130 centers in 27 countries, from the medical records and at a visit at least 6 months after hospitalization for a coronary event. All lipid measurements were performed in one central laboratory. Patients were divided into three groups: on high-intensity LDL-C-lowering-drug therapy (LLT), on low or moderate-intensity LLT and on no LLT. Results: At the time of the visit, almost half of the patients were on a high-intensity LLT. Between hospital discharge and the visit, LLT had been reduced in intensity or interrupted in 20.8% of the patients and had been started or increased in intensity in 11.7%. In those who had interrupted LLT or had reduced the intensity, intolerance to LLT and the advice of their physician were reported as the reason why in 15.8 and 36.8% of the cases, respectively. LDL-C control was better in those on a high-intensity LLT compared to those on low or moderate intensity LLT. LDL-C control was better in men than women and in patients with self-reported diabetes. Conclusions: The results of the EUROASPIRE V survey show that most coronary patients have a less than optimal management of LDL-C. More professional strategies are needed, aiming at lifestyle changes and LLT adapted to the need of the individual patient.
Published: 2019

30. Measurement of myocardial accumulation of123I-metaiodobenzylguanidine for studying cardiac autonomic neuropathy in diabetes mellitus

Author: Mäntysaari, M., Kuikka, J., Mustonen, J., Tahvanainen, K., Vanninen, E., Länsimies, E., and Uusitupa, M.
Published: 1996
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31. Severity of tubulointerstitial inflammation and prognosis in immunoglobulin A nephropathy

Author: Myllymäki, J M, Honkanen, T T, Syrjänen, J T, Helin, H J, Rantala, I S, Pasternack, A I, and Mustonen, J T
Published: 2007

32. Ten-year prognosis of Puumala hantavirus-induced acute interstitial nephritis

Author: Miettinen, M H, Mäkelä, S M, Ala-Houhala, I O, Huhtala, H SA, Kööbi, T, Vaheri, A I, Pasternack, A I, Pörsti, I H, and Mustonen, J T
Published: 2006

33. Five-year risk of developing clinical diabetes after first myocardial infarction; the FINAMI study

Author: Pajunen, P., Koukkunen, H., Ketonen, M., Jerkkola, T., Immonen-Räihä, P., Kärjä-Koskenkari, P., Mähönen, M., Niemelä, M., Kuulasmaa, K., Palomäki, P., Mustonen, J., Lehtonen, A., Arstila, M., Vuorenmaa, T., Lehto, S., Miettinen, H., Juolevi, A., Torppa, J., Tuomilehto, J., Kesäniemi, Y. A., Pyörälä, K., and Salomaa, V.
Published: 2005

34. Value of Ultrasonography in Acute Renal Failure: Analysis of Qualitative Features in Patients with Nephropathia Epidemica

Author: PAAKKALA, A., KALLIO, T., HUHTALA, H., APULI, P., PAAKKALA, T., and MUSTONEN, J.
Published: 2004

35. Death rates and causes of death in patients with rheumatoid arthritis: a population-based study

Author: Sihvonen, S, Korpela, M, Laippala, P, Mustonen, J, and Pasternack, A
Published: 2004

36. Demonstration of disturbed free fatty acid metabolism of myocardium in patients with non-insulin-dependent diabetes mellitus as measured with iodine-123-heptadecanoic acid

Author: Kuikka, J. T., Mustonen, J. N., Uusitupa, M. U., Rautio, P., Vanninen, E., Laakso, M., Länsimies, E., and Pyörälä, K.
Published: 1991
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37. Renal ultrasound findings and their clinical associations in Nephropathia epidemica: Analysis of quantitative parameters

Author: Paakkala, A., Kallio, T., Huhtala, H., Apuli, P., Paakkala, T., Pasternack, A., and Mustonen, J.
Published: 2002

38. HEPATIC SUBCAPSULAR STEATOSIS IN DIABETIC CAPD PATIENTS TREATED WITH INTRAPERITONEAL INSULIN: Description of a typical pattern

Author: Kallio, T., Nevalainen, P. I., Lahtela, J. T., Mustonen, J., and Pasternack, A.
Published: 2001

39. Urinary albumin excretion rate is independently related to autonomic neuropathy in type 2 diabetes mellitus

Author: WIRTA, O. R., PASTERNACK, A. I., MUSTONEN, J. T., LAIPPALA, P. J., and REINIKAINEN, P. M.
Published: 1999

40. Corrigendum to “Celiac disease or positive tissue transglutaminase antibodies in patients undergoing renal biopsies” [Dig Liver Dis (2018);50:27–31]

Author: Nurmi, R., primary, Metso, M., additional, Pörsti, I., additional, Niemelä, O., additional, Huhtala, H., additional, Mustonen, J., additional, Kaukinen, K., additional, and Mäkelä, S., additional
Published: 2019
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41. Association of HLA B27 with Benign Clinical Course of Nephropathia Epidemica Caused by Puumala Hantavirus

Author: MUSTONEN, J., PARTANEN, J., KANERVA, M., PIETILÄ, K., VAPALAHTI, O., PASTERNACK, A., and VAHERI, A.
Published: 1998

42. Antibody Reactivity Against Thyroid Peroxidase and Myeloperoxidase in Autoimmune Thyroiditis and Systemic Vasculitis

Author: HAAPALA, A. M., HYÖTY, H., PARKKONEN, P., MUSTONEN, J., and SOPPI, E.
Published: 1997

43. Changes in autonomic nervous function during the 4-year follow-up in middle-aged diabetic and nondiabetic subjects initially free of coronary heart disease

Author: MUSTONEN, J., UUSITUPA, M., MÄNTYSAARI, M., LÄNSIMIES, E., and PYÖRÄLÄ, K.
Published: 1997

44. Primary aldosteronism: Higher volume load, cardiac output and arterial stiffness than in essential hypertension.

Author: Choudhary, M. K., Värri, E., Matikainen, N., Koskela, J., Tikkakoski, A. J., Kähönen, M., Niemelä, O., Mustonen, J., Nevalainen, P. I., and Pörsti, I.
Subjects: CARDIAC output, ARTERIAL diseases, ESSENTIAL hypertension, VASCULAR resistance, HYPERALDOSTERONISM
Abstract: Background: The diagnostics of primary aldosteronism (PA) are usually carried out in patients taking antihypertensive medications. We compared haemodynamics between medicated PA, medicated essential hypertension (EH), never‐medicated EH and normotensive controls (n = 130 in all groups). Methods: The hypertensive groups were matched for age (53 years), sex (84 male/46 female) and body mass index (BMI) (30 kg m−2); normotensive controls had similar sex distribution (age 48 years, BMI 27 kg m−2). Haemodynamics were recorded using whole‐body impedance cardiography and radial pulse wave analysis, and the results were adjusted as appropriate. Radial blood pressure recordings were calibrated by brachial blood pressure measurements from the contralateral arm. Results: Radial and aortic systolic and diastolic blood pressure was similar in PA and never‐medicated EH, and higher than in medicated EH and normotensive controls (P ≤ 0.001 for all comparisons). Extracellular water balance was ~ 4% higher in PA than in all other groups (P < 0.05 for all), whilst cardiac output was ~ 8% higher in PA than in medicated EH (P = 0.012). Systemic vascular resistance and augmentation index were similarly increased in PA and both EH groups when compared with controls. Pulse wave velocity was higher in PA and never‐medicated EH than in medicated EH and normotensive controls (P ≤ 0.033 for all comparisons). Conclusions: Medicated PA patients presented with corresponding systemic vascular resistance and wave reflection, but higher extracellular water volume, cardiac output and arterial stiffness than medicated EH patients. Whether the systematic evaluation of these features would benefit the clinical diagnostics of PA remains to be studied in future. [ABSTRACT FROM AUTHOR]
Published: 2021
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45. Ancient Aliens -televisiosarjasta välittyvät arkeologikuvat

Author: Mustonen, J. (Janne)
Subjects: Archaeology
Abstract: Tämä tutkielma käsittelee Ancient Aliens -televisiosarjasta välittyviä arkeologikuvia. Kyseisessä televisiosarjassa pyritään todistelemaan muinaisastronauttiteoriaa, jonka mukaan maapallolla on vieraillut älyllisiä olentoja maapallon ulkopuolelta ja, jotka ovat vaikuttaneet ihmislajin kehitykseen. Ancient Aliens -televisiosarja on osa pseudoarkeologian kirjoa. Pseudoarkeologialla tarkoitetaan näennäisarkeologiaa, jolle tyypillistä on tieteen kriteerien laiminlyönti sekä vihamielinen asenne akateemista arkeologiaa kohtaan. Tutkielman tarkoitus on täten lisätä tietämystä pseudoarkeologiasta ja sen vaikutuksista arkeologien imagoon. Tutkielman aineisto koostuu Ancient Aliens -sarjan jaksoista, joista olen suorittanut ositetun otannan. Ohjelman välittämiä arkeologikuvia hahmotetaan ohjelmassa esiintyvien arkeologien puheiden sekä muun muassa heidän visuaalisen ulosantinsa kautta. Myös sarjassa esiintyvä arkeologeja koskeva verbaalinen viestintä on huomion keskiössä. Tutkielmassa käydään läpi myös Ancient Aliens -televisiosarjasta välittyvien arkeologikuvien ajalliset muutokset. Lopuksi tutkielman aineistosta havaittuja arkeologikuvia verrataan aiemmissa tutkimuksissa havaittuihin arkeologikuviin. Keskeisenä tutkimusmenetelmänä tutkielmassa on sisällönanalyysi, jonka avulla laajasta aineistosta tehdyt havainnot on luokiteltu ylä- ja alaluokkiin. Tutkielma antoi monenlaisia tutkimustuloksia. Arkeologit esitettiin pätevinä menneisyyden selittäjinä, mutta myös epäpätevinä työhönsä. He näkyivät myös homogeenisena ryhmänä, joita sävytti mm. seikkailija- ja etsijästereotypiat ja heidän keskeisiä tutkimuskohteitaan olivat kaukaiset ja ajanlaskun alkua edeltävät kohteet. Myös koloniaalista luonnetta esiintyi. Arkeologit olivat harvemmin tekemisissä teknisten laitteiden tai ajanlaskun jälkeisten kohteiden kanssa. Sarjan arkeologit olivat usein keski-ikäisiä ja pukeutuivat keskiluokkaisesti. Huippukausi arkeologeja koskevassa retoriikassa ajoittui sarjan puoliväliin 2013 vuodelle. Arkeologeja koskeva retoriikka näyttäisi kuitenkin olevan lievässä nousussa 2016 vuodelle tullessa. Yhtäläisyyksiä tutkielmassa sekä aiemmassa tutkimuksessa havaittujen arkeologikuvien välillä on arkeologien koloniaalisen luonteen, sekä etsijä ja seikkailija-assosiaatioiden välillä. Eroavaisuuksia sen sijaan ilmeni muun muassa siinä, ovatko arkeologikuvat muuttumassa sukupuolisesti tasa-arvoisempaan suuntaan. Tutkielman perusteella harva Ancient Aliens -sarjan arkeologikuvista oli realistisia, saati ongelmattomia. Toisaalta myös positiivisia representaatioita ilmeni — silloin kun se pseudoarkeologeille oli hyödyllistä. Arkeologien esittäminen ohjelmassa oli siis hyvin valikoivaa ja myös eri arkeologeja arvottavaa. Arkeologien tulisi suhtautua Ancient Aliens -sarjaan vakavuudella, sillä ohjelmaa katsoo noin 1–2 miljoonaa ihmistä per jakso, mikä tarkoittaa, että ohjelman kautta kyetään välittämään arkeologeja koskevia viestejä laajalle kuulijajoukolle. Ohjelma on myös jatkunut jo 11:n tuotantokauden verran, eikä loppua ole toistaiseksi näkyvissä. Toisaalta arkeologia on keskiössä ohjelmassa, jolloin arkeologia tieteenä saa osakseen mainostusta ja voi täten saada ihmiset kiinnostumaan tieteenalasta ja motivoitumaan etsimään siitä lisää tietoa. Parempi vaihtoehto voisi kuitenkin olla pyrkiä vastustamaan Ancient Aliens -sarjan arkeologikuvia. Tämä voisi onnistua arkeologian tehokkaammalla popularisoinnilla, sekä mediakriittisyyden lisäämisellä ihmisten keskuudessa. This thesis handles the images of archaeologists from Ancient Aliens -television series. In this television programme, ancient astronaut -theory is attempted to be proven. Ancient astronaut -theory claims that Earth have received intelligent visitors from outer space which had influenced mankind’s history. Ancient Aliens -series is a part of pseudoarchaeology which often neglects scientific criteria and holds hostile attitude towards academic archaeology. This thesis attempts to add knowledge about pseudoarchaeology and its impacts to the image of archaeologists. Research material consists of episodes of Ancient Aliens -series. Images of the archaeologists are perceived through the speeches and appearances of the archaeologists. Also, the verbal communication that handles archaeologists is in focus. This thesis also handles the secular changes of representation of archaeologists in Ancient Aliens -programme. Lastly the results are compared with earlier research of images of the archaeologists. The main research method in this thesis is content analysis. This thesis gave many kinds of results. Archaeologists were portrayed as qualified but also incompetent researchers of the past. They were portrayed as a homogenic group with adventurer and searcher stereotypes. Their main research targets were pre-calendar and exotic sites. Colonial image wasn’t also untypical. More seldom archaeologists were working with technological devices. Archaeologists of Ancient Aliens -programme were often middle-aged and were dressed in blouse. Top season of representation of archaeologists was around year 2013. However, rhetoric that handles archaeologists seems to be in slight increase in most recent seasons. There were much similarities with earlier researcher. Both stated that archaeologists were represented as a colonialists and searcher-adventurer associations were typical. Differences appeared whether the image of the archaeologists is changing into sexually more equal. Research results claim that few of the archaeologist images were realistic nor problem-free. However, the positive representations also occurred — when it was beneficial to pseudoarchaeologists. In this sense, representation of archaeologists was selective and archaeologists were evaluated. Archaeologists should be concerned about Ancient Aliens -programme. The show is being watched by 1–2 million people per episode which means that through this programme people can send their messages to a large group. The show has also continued long and currently there is no end in sight. However, archaeology is in the centre in this show, which means that archaeology receives advertising which can lead people to gain interest of it. Better alternative could still be trying to resist the show and its representations. This could happen by popularising the archaeology more effectively and by adding the critical thinking among population.
Published: 2017

46. Ezetimibe added to statin therapy after acute coronary syndromes

Author: Cannon, Christopher P., Blazing, Michael A., Giugliano, Robert P., Mccagg, Amy, White, Jennifer A., Theroux, Pierre, Darius, Harald, Lewis, Basil S., Ophuis, Ton Oude, Jukema, J. Wouter, De Ferrari, Gaetano M., Ruzyllo, Witold, De Lucca, Paul, Kyungah, Im, Bohula, Erin A., Reist, Craig, Wiviott, Stephen D., Tershakovec, Andrew M., Musliner, Thomas A., Braunwald, Eugene, Califf, Musliner T, Robert M., Tershakovec, A, Gurfinkel, E, Aylward, P, Tonkin, A, Maurer, G, Van de Werf, F, Nicolau, Jc, Theroux, P, Genest, J, Armstrong, P, Corbalan, R, Isaza, D, Spinar, J, Grande, P, Voitk, J, Kesaniemi, A, Bassand, Jp, Farnier, M, Darius, H, Keltai, M, Mathur, A, Mittal, S, Reddy, K, Lewis, B, De Ferrari GM, Ophuis, To, Jukema, J, White, H, Pedersen, T, Britto, F, Ruzyllo, W, Carrageta, M, Duris, T, Dalby, A, Seung, Kb, Lopez-Sendon, J, Dellborg, M, Mach, F, Guneri, S, Parkhomenko, A, Brady, A, Cannon, C, Blazing, M, Ballantyne, C, de Lemos, J, Kleiman, N, Mcguire, Dk, Centeno, E, Casalins, M, Cartasegna, L, Beltrano, Mc, Guerrero, R, Fanuele, M, Berra, F, Egido, J, Colombo, H, Dellatorre, M, Terns, P, Blumberg, E, Reges, P, Azize, G, Ramos, H, Fernandez, R, Carlessi, C, Milesi, R, Schmuck, R, Duronto, E, Procopio, G, Carlevaro, O, Maffeo, H, Beloscar, J, Viso, M, Hominal, M, Castoldi, M, Bluguermann, J, Mauro, D, Macin, S, Cocco, N, Ruiz, N, Ricart, J, Lozada, A, Nani, S, Turri, D, Fernandez, H, Caruso, O, Zarandon, R, Bono, J, Arias, V, Allall, O, Marino, J, Cusimano, S, Schygiel, P, Buzetti, C, Penaloza, N, Berli, M, Worthley, S, Roach, A, Chew, D, Wright, T, Leitch, J, Hicks, E, Rankin, J, Venn-Edmonds, C, Lehman, R, Morrison, H, Shaw, J, Mak, V, Hii, C, Smith, K, Cross, D, Lilwall, L, Nelson, G, Loxton, A, Horowitz, J, Rose, J, Steinwender, C, Leisch, F, Kammler, J, Brussee, H, Zweiker, R, Niederl, E, Weihs, W, Giorgio, G, Lang, I, Drexel, H, Zanolin, D, Hoppe, U, Atzenhofer-Baumgartner, K, Pichler, M, Hainzer, D, Eber, B, Pichler, F, Foeger, B, Wechselberger, T, Mayr, H, Hofer, J, Stockenhuber, F, Warlits, B, Huber, K, Egger, F, Weidinger, F, Ziegler, B, Jirak, P, Metzler, B, Pachinger, O, Wanitschek, M, Auer, J, Grabscheit, G, Podczeck-Schweighofer, A, Priesnitz, T, Frank, H, El Allaf, D, Marechal, P, Roosen, J, Joly, E, Lefebvre, P, Arend, C, Sinnaeve, P, De Velder, L, Hellemans, S, Vanhauwaert, B, Van Dorpe, A, Heyse, A, Vantomme, C, Striekwold, H, Van Den Broeck, D, Lancellotti, P, Schoors, D, Lemoine, I, Taeymans, Y, De Wolf, L, Brike, C, Vercauteren, S, Tahon, S, Vervoort, G, Mestdagh, I, Pirenne, B, Cardinal, F, Lips, S, Dujardin, K, Debrouwer, K, Dhooghe, G, Holvoet, G, van de Borne, P, Renard, M, De Clippel, M, Lesseliers, H, Van Miert, N, Saraiva, J, Vicente, C, Rossi, P, Dos Santos LB, Duda, N, Tognon, Ap, Serrano, C, Gomes, Fl, Manenti, Er, Silveira, Ds, Maia, L, Mouco, Om, Paiva, M, Antonangelo, A, de Souza, J, Lino, Ea, Leães, P, Blacher, Mg, Kormann, A, Ultramari, Ft, Dutra, O, Mendelski, Am, Morgado, S, Ardito, W, Greque, G, Ardito, Rv, Pimentel Filho, P, Zucchetti, C, Alves, A, Seabra, Am, Mattos, M, Miranda, Lf, Silva, D, Uehara, Rm, Marin Neto, J, Schmidt, A, Braga, J, Rodrigues, A, Abrantes, J, Pinheiro, L, Bodanese, L, Magedanz, Éh, Piegas, L, Dos Santos ES, Wainstein, M, Ribeiro, J, Stein, R, Marino, R, Machado, Vm, Moraes Junior, J, Guimarães, S, da Costa FA, Ferraz, Rf, Albuquerque, D, Rocha, Rm, de Carvalho Moreira, R, Dohmann, H, Costantini, C, Tarastchuk, Jc, Coelho, O, Cirillo, W, Sousa, A, Almeira, As, Stefanini, E, Silva, F, Teixeira, M, da Cunha, C, Précoma, D, Facchi, Tl, Rupka, D, Thiessen, S, Warnica, J, Smith, B, Della Siega, A, Klinke, P, Nelson, S, Dion, D, Gilbert, N, Hui, W, Kvill, L, Sussex, B, Luther, A, Dupuis, R, Ouimet, F, Pandey, A, Clarus, S, Senaratne, M, Ferdinandis, H, Mukherjee, A, Bozek, B, Vizel, S, Markov, G, Zimmermann, R, Stephens, W, Tremblay, B, Wong, G, Uchida, N, Brossoit, R, Peck, C, Van Kieu, C, Forgione, M, Bata, I, Cossett, J, Kostuk, W, Arnold, M, Bone, C, Grondin, F, Bilodeau, N, Gosselin, G, David, M, Giannoccaro, J, Beresford, P, Polasek, P, Roberts, P, Doucet, M, Beaudry, M, Cheung, S, Cleveland, T, Bhargava, R, Mccallum, A, Ma, P, Morrissette, J, Cleveland, D, Chadwyn, D, Nigro, F, Weeks, A, Cryderman, C, Leader, R, Houde, G, Rousseau, S, Pearce, M, Radyk, M, Lonn, E, Magi, A, Lefkowitz, C, Sandrin, F, Coffin, N, Lubelsky, B, Coldwell, J, Habot, J, Mcpherson, C, De Larochelliere, R, Roy, M, Haichin, R, Barber, C, Bhesania, T, Kitagawa, H, To, T, Donnelly, B, Tymchak, W, Harris, L, Kouz, S, Huynh, T, St Jacques, B, Lamy, A, Rizzo, A, Stein, J, Childs, C, Wong, B, Poirier, R, Gupta, M, Dela Cruz, C, Constance, C, Gauthier, M, Ervin, F, Ouellette, M, Kokis, A, Lemay, C, Kwok, K, Leung, C, Lee, D, Nesmith, J, Renton, J, Syan, G, Turek, M, Hogan, D, Griffin, P, Lipson, A, Winestock, J, Abramson, B, Fogel, A, Gagne, C, Bergeron, J, Clarke, A, Slipp, S, Darcel, I, Carling-Chambers, L, Kannampuzha, P, Pallie, S, Krekorian, S, Vertes, G, Roth, S, Lai, K, Heath, J, Perez, L, Arriagada, G, Castro, P, Villa, F, Rodríguez, M, Ramos, G, Baraona, F, Núñez, A, García, M, Jofre, C, Silva, P, Lamich, R, Yovaniniz, P, Escobar, E, Dussaubat, A, Segura, E, Ramirez, M, Lapostol, C, Palma, A, Encina, L, Zapata, M, Baeza, N, Varela, P, Pérez, L, Jaramillo, C, Ruiz, S, Sanchez, G, Perdomo, I, Manzur, F, Cohen, Le, Velasquez, J, Arana, C, Alvarez, Y, Triana, M, Balaguera, J, de Salazar, D, Rendon, N, Botero, R, Ruiz, A, Saaibi, J, Medina, J, Jaramillo, M, Calderón, Mj, Delgado, J, Bohorquez, R, Medina, Mf, Herrera, M, Rosales, D, Mendoza, F, Martinez, S, Ternera, A, Castro, R, Baiz, A, Martinez, M, Orozco, A, Suarez, M, Fonseca, Y, Beltran, R, Cepeda, M, Jaramillo, N, Valenzuela, C, Gutierrez, M, Sanchez, A, Vitovec, J, Hlinomaz, O, Poloczek, M, Mayer, O, Veselka, J, Vejvoda, J, Soucek, M, Spac, J, Novobilsky, K, Srp, V, Francek, L, Branny, M, Sknouril, L, Motovska, Z, Rohac, F, Stankova, A, Fiala, T, Holub, M, Zeman, K, Pohludkova, L, Pospisilova, E, Tuma, P, Cihalik, C, Oral, I, Podpera, I, Stepanovova, R, Uricar, M, Solar, M, Pelouch, R, Porzer, M, Grussmannova, K, Stipal, R, Reichert, P, Hradec, J, Kral, J, Sejkova, B, Janek, B, Pitha, J, Linhart, A, Polacek, P, Koeber, L, Clemmensen, P, Hebin, Ch, Schmidt, E, Pedersen, Ms, Roseva-Nielsen, N, Kristensen, K, Bang-Hansen, T, Jensen, J, Laage-Petersen, J, Nielsen, H, Stokholm, E, Thayssen, P, Cappelen, H, Jensen, T, Winther-Friis, B, Klausen, I, Hedegaard, B, May, O, Andersen, M, Bottzauw, J, Lush, A, Markenvard, J, Vestager, Km, Bronnum-Schou, J, Hempel, H, Petersen, J, Nielsen, Aj, Thomsen, K, Nielsen, T, Nygaard, A, Sykulski, R, Jensen, Bs, Ralfkiaer, N, Gottschalck, H, Rasmussen, S, Pedersen, Lr, Dodt, K, Skovsbøl, M, Andersen, O, Tuxen, C, Meier, Aw, Kristensen, T, Rasmussen, O, Lopez, J, Salazar, D, Sanchez, L, Rosero, F, Penaherrera, E, Duarte, Yc, Marmol, R, Andrade, G, Guzman, E, Morillo, A, Aug, L, Loogna, I, Laanmets, P, Mustonen, J, Mäntylä, P, Kesäniemi, A, Ukkola, O, Kervinen, H, Juhela, S, Juvonen, J, Toppinen, A, Jarvenpaa, J, Syvanne, M, Svahn, T, Voutilainen, S, Huotari, A, Nikkila, M, Raiskinmäki, S, 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Jinich, D., Tam, K., Vogel, C., Aggarwal, R., Zakhary, B., Curtis, S., Lyster, M., Humphrey, K., Lavine, P., Fujise, K., Birnbaum, Y., Allen, J., Kesselbrenner, M., Michel, K., Staniloae, C., Liu, M., Sonel, A., Macioce-Caffas, A., Amidon, T., Leggett, J., Yedinak, S., Gudmundsson, G., Sabharwal, J., Dagefoerde, N., Wu, W., Meyerrose, G., Roongsritong, C., Jenkins, L., Lieberman, S., Sokol, S., Gutierrez, C., Nelson, C., Barrett, J., Hotchkiss, D., Farley, A., Atassi, K., Christy, L., Baig, M., Di Fazio, J., Meengs, M., Thomas, K., Surmitis, J., DeVault, S., Farhat, N., Hulyalkar, A., Riddell, L., Rivera, W., Sheynberg, B., Kobayashi, J., Katsaropoulos, J., Jan, M., Krucoff, M., Paterno, C., Chandrasekaran, S., Curry, R., Cassavar, D., Wheeler, M., McGarvey, J., Schwarz, L., Miller, E., Andrea, B., Carswell, B.S., Lurie, M., Patti, J., Bowden, W., Vasiliauskas, T., Latham, R., Schwartz, B., Bradford, L., Mattleman, S., Wertheimer, J., Goulden, D., Khan, M., Hawkins, B., Ostfeld, R., Mueller, H., Ash, Y., Wilson, V., Bayer, M., Marshall, J., Dobies, D., Dawson, G., Osman, A., Saba, F., Costello, T., Fuentes, F., Underwood, C., Vijay, N., Washam, M., Dietz, W., Glasgow, B., Mukherjee, S., Hinchion, N., Speirs, S., Thornley, A., Lee, K., Movahed, M., Strootman, D., Chernick, R., Parrott, C., Flock, C., Marques, V., Syzmanski, E., Rama, P., Domingo, D., Wu, L., Bauer, B., Dionisopoulos, P., Aggarwal, A., Holcomb, R., Foster, R., Hancock, T., Hargrove, J., Fletcher, A., Stine, R., Bullivant, M., Adams, K., Lohman, J., Klepper, V., Kabour, A., Neidhardt, J., Phillips, W., Tardiff, S., Aji, J., Corut, S., Foster, G., Firek, C., St Goar, F., Sumner, R., Davis, T., Schneider, R., Schneider, W., Villa, A., Desai, V., Chhabra, A., Banks, K., Herzog, W., Burley, T., Quyyumi, A., Smiley, W., Manocha, P., Fishbein, G., Weller, C., Coffman, A., Kim, C., Kedia, A., Firth, B., Rizvi, M., Dahiya, R., Foster, B., Balcells, E., Metzger, D.C., Lester, J., Bissett, J., Fahdi, I., Sides, E.A., Azrin, M., Martin, C., Quick, A., Conaway, D., Garg, M., Schallert, G., Lancaster, L., Mckissick, S., Atieh, M., Garbarino, J., Eisenberg, D., Uusinarkaus, K., Wirtemburg, P., Ellis, J., Cristaldi, J., Berglund, R., Negus, B., Pappas, J., Rocha, R., Nguyen, T., Stone, J., Janosik, D., Labovitz, A., Elmore, N., Dave, R., Loffredo, K., Gabriel, G., Snyder, C., Ahmed, O., Stone, H., Kelley, M., Diffenback, M., Friedman, B., Zirkle, J., Severa, L., Sample, S., Dignen, K., Raisinghani, A., Ben-Yehuda, O., Ghannadian, B., Moscoso, R., Mankowski, J., Boliek, W., Rukavina, M., Davis, W., Ledbetter, S., Handel, F., Mastouri, R., Mahenthiran, J., Foltz, J., Malhotra, V., Jonas, J., Berk, M., Singh, V., Nelson, M., Elsner, G., Gall, J., Kondo, N., Frank, S., Chandraratna, P., Ranasinghe, S., Ebrahimi, R., Treadwell, M., Walters, B., Hughes, L., Kramer, J., Kumar, K., Mente, T., Lachterman, B., Schifferdecker, B., Munshi, K., Sease, D., Waldo, D., Chandler, G., Manns, D., Nahhas, A., Kamalesh, M., Williams, V., Reich, D., Desalca, M., Sharma, S., Liston, M., Gupta, K., Costa, M., Altschuller, A., Lemmertz, K., Shanes, J., Hansen, C., Therrien, M., Mendelson, R., Ramnarine, R., Myers, G., Donovan, C., Klein, M., Fine, D., Owens, S., Murray, C., Ketroser, R., Heifetz, S., Darnell, Z., Touchon, R., Taghizadeh, B., Bohle, D., Norwood, D., Forrest, T., Jackson, S., Shumate, K., Bayles, A., Masroor, M., North, W.K., Fishberg, R., Merveil-Ceneus, B., Butcher, R., Menapace, F., Kilbride, S., Ramabadran, R.S., Loukinen, K., Khalil, J., Ramabadran, R., Walsh, S., Gill, S., Cyncar, R., McLachlan, J., Surakanti, V., Rusterholtz, L., Shoukfeh, F., Stephenson, L., Tsang, M., Nolan, V., Gilchrist, I., Jefferson, D., Feldman, T., Reyes, L., Santos, R., Little, W., Wesley, D., Gharib, W., Mendell, A., Esham, G., Kakavas, P., Whitcomb, C., Book, K., Bazzi, A., Alvarez, J., Cohen, Y., Ayres, T., Rhule, V., Labib, A., Schuler, P., Zughaib, M., Telck, K., Bikkina, M., Turnbull, K., Sharma, T., Orosz, S., Shah, R., Petrino, M., Hughes, M., Hershey, J., Hudock, D., Hui, P., Von Bakonyi, A., Arnold, A., Kappel, D., Pennock, G., Cloud, B., Tucker, K., Harp, L., Hoover, C., Eisenhauer, M., Roth, J., Young, C., Thai, H., Escalante, A., Bautista, J., Gazmuri, R., Nyland, J., Cubeddu, L., DeFranco, A., Dias, D., Fielding, M., Reeves, R., Hermany, P., Meissner-Dengler, S., Evans, M., Flores, E., Tannenbaum, A., McGarr, K., Moran, J., Stout, E., Allred, S., Henderson, D., Crandall, L., Strote, J., Voyles, W., Robeson, D., Bedoya, R., Omar, B., Pettyjohn, F., Revere, C., Coy, K., Margolis, J., Sotolongo, C., Scheffel, M., Munir, A., Shirwany, A., Douglas, L., Girala, R., Humphreys, R., Agarwal, J., Bankowski, D., Watson, R., Bishop, B., Klementowicz, P., Blais, D., Cohen, B., Lobur, E., Dimenna, J., Dempsey, K., Izzo, M., Bondi, L., Carell, E., Eaton, C., Saltiel, F., Grewal, G., Connolly, T., Little, T., Wiegman, P., Gips, S., Held, J., Paraschos, A., Quesada, R., Goudreau, E., Sears, M., Istfan, P., Holt, S., McClung, J., Nguyen, N., Quintana, O., Gottlieb, D., Knutson, T., Barringhaus, K., Lester, F., Sullivan, P., Rodriguez-Ospina, L., Cannon, Cp, Blazing, Ma, Giugliano, Rp, Mccagg, A, White, Ja, Theroux, P, Darius, H, Lewis, B, Ophuis, To, Jukema, Jw, De Ferrari, Gm, Ruzyllo, W, De Lucca, P, Im, K, Bohula, Ea, Reist, C, Wiviott, Sd, Tershakovec, Am, Musliner, Ta, Braunwald, E, Califf, Rm, for the IMPROVE-IT, Investigator, Cianflone, D, Cardiovascular Division (SZG), Brigham and Women's Hospital [Boston], College of Information Science and Engineering, Ritsumeikan University, Montreal Heart Institute (MONTREAL HEART INSTITUTE), Laboratoire des Micro-algues toxiques, Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD)-Institut de Recherche pour le Développement (IRD), Interuniversity Cardiology Institute Netherlands, Institute of Cardiology (WARSAW - Cardiology), Institute of Cardiology, Merck Sharp & Dohme Corp., Merck & Co. Inc, DIPARTIMENTO DI MEDICINA SPECIALISTICA, DIAGNOSTICA E SPERIMENTALE, Facolta' di MEDICINA e CHIRURGIA, AREA MIN. 06 - Scienze mediche, Cannon, C.P., Blazing, M.A., Giugliano, R.P., Mccagg, A., White, J.A., Lewis, B.S., Jukema, J.W., De Lucca, P., Im, K., Bohula, E.A., Reist, C., Wiviott, S.D., Tershakovec, A.M., Musliner, T.A., Braunwald, E., Califf, R.M., for the IMPROVE-IT Investigators [.., C. Rapezzi, ], Other departments, Cannon, Christopher P, Blazing, Michael A., Giugliano, Robert P., Mccagg, Amy, White, Jennifer A., Theroux, Pierre, Darius, Harald, Lewis, Basil S., Ophuis, Ton Oude, Jukema, J. Wouter, De Ferrari, Gaetano M., Ruzyllo, Witold, De Lucca, Paul, Kyungah, Im, Bohula, Erin A., Reist, Craig, Wiviott, Stephen D., Tershakovec, Andrew M., Musliner, Thomas A., Braunwald, Eugene, and Califf, Robert M.
Subjects: Male, Simvastatin, acute coronary syndrome, aged, anticholesteremic agents, azetidines, cardiovascular diseases, cholesterol, ldl, double-blind method, drug therapy, combination, ezetimibe, female, humans, hydroxymethylglutaryl-coa reductase inhibitors, kaplan-meier estimate, male, middle aged, simvastatin, triglycerides, medicine (all, [SDV]Life Sciences [q-bio], Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Bococizumab, Triglyceride, chemistry.chemical_compound, 0302 clinical medicine, Azetidine, Cardiovascular Disease, Anticholesteremic Agent, Acute Coronary Syndrome, Aged, Anticholesteremic Agents, Azetidines, Cardiovascular Diseases, Cholesterol, LDL, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Middle Aged, Triglycerides, 030212 general & internal medicine, Medicine (all), Research Support, Non-U.S. Gov't, Hazard ratio, General Medicine, Acute Coronary Syndrome, Aged, Anticholesteremic Agents, Azetidines, Cardiovascular Diseases, Ezetimibe, Female, Humans, Male, Middle Aged, 3. Good health, Multicenter Study, Editorial, Cholesterol, Randomized Controlled Trial, Combination, Ezetimibe, lipids (amino acids, peptides, and proteins), Human, medicine.drug, medicine.medical_specialty, Acute Coronary Syndroms, Urology, Acute Coronary Syndrome/drug therapy, Anticholesteremic Agents/adverse effects, Anticholesteremic Agents/therapeutic use, Azetidines/adverse effects, Azetidines/therapeutic use, Cardiovascular Diseases/epidemiology, Cardiovascular Diseases/mortality, Cardiovascular Diseases/prevention & control, Cholesterol, LDL/blood, Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects, Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use, Simvastatin/therapeutic use, Triglycerides/blood, NO, LDL, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Drug Therapy, Internal medicine, Journal Article, medicine, Comparative Study, Alirocumab, business.industry, PCSK9, ta3121, Lomitapide, DOENÇAS CARDIOVASCULARES, Endocrinology, chemistry, Statin Therapy, Hydroxymethylglutaryl-CoA Reductase Inhibitor, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known.METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization (≥30 days after randomization), or nonfatal stroke. The median follow-up was 6 years.RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (PCONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit. (Funded by Merck; IMPROVE-IT ClinicalTrials.gov number, NCT00202878.).
Published: 2015
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47. Immunological comparison of patients with rheumatoid arthritis with and without nephropathy

Author: Korpela, M., Mustonen, J., Helin, H., and Pasternack, A.
Subjects: Rheumatoid arthritis -- Physiological aspects, Rheumatoid arthritis -- Complications, Kidney diseases -- Causes of, Health
Abstract: Rheumatoid arthritis (RA) is a joint disease characterized by inflammation of the joints, stiffness, swelling, overgrowth of cartilage tissue, and pain. It is associated with the production of abnormal immune system factors such as rheumatoid factor, antinuclear antibodies, and circulating immune complexes, as well as altered levels of immunoglobulins (Ig; immune proteins) and complement (proteins that destroy bacteria and other foreign cells). RA may be associated with complications of the kidney, including mesangial nephropathy, disease of the tissue supporting the glomeruli, which filter blood through the kidney; membranous glomerulonephritis, the inflammation of the kidney with the development of membranes; and amyloidosis, the deposition of amyloid, a protein-carbohydrate substance, in the tissue and organs. The levels of various types of Ig, the complement proteins C3 and C4, circulating immune complexes, and antinuclear antibodies, were measured in 56 RA patients with mesangial nephropathy, 13 RA patients with membranous glomerulonephritis, 20 RA patients with amyloidosis, and 35 RA patients without kidney disease. IgA and IgM levels were higher in patients with mesangial nephropathy and amyloidosis than in RA patients without kidney disease. IgA levels were higher in patients with IgA deposits than those without IgA deposits, and highest in patients with IgA glomerulonephritis, which occurred in five percent of RA patients. The results show that circulating immune complexes do not have a major role in kidney disorders associated with RA. (Consumer Summary produced by Reliance Medical Information, Inc.)
Published: 1990

48. 3PC-012 Stability of cefuroxime 80 mg/ml solution in ready-to-administer polypropylene syringes

Author: Helin-Tanninen, M, primary, Mustonen, J, additional, Lehtonen, M, additional, and Korhonen, O, additional
Published: 2018
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49. Ultrasound Screening of Men with Coronary Artery Disease for Abdominal Aortic Aneurysms: A Prospective Dual Center Study

Author: Vänni, V., primary, Hakala, T., additional, Mustonen, J., additional, Turtiainen, J., additional, Rissanen, T. T., additional, Kajander, O., additional, Ilveskoski, E., additional, Koivumäki, J., additional, Eskola, M., additional, and Hernesniemi, J., additional
Published: 2016
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50. Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes.

Author: IMPROVE-IT Investigators, Musliner, T., Tershakovec, A., Gurfinkel, E., Aylward, P., Tonkin, A., Maurer, G., Van de Werf, F., Nicolau, J.C., Theroux, P., Genest, J., Armstrong, P., Corbalan, R., Isaza, D., Spinar, J., Grande, P., Voitk, J., Kesaniemi, A., Bassand, J.P., Farnier, M., Darius, H., Keltai, M., Mathur, A., Mittal, S., Reddy, K., Lewis, B., De Ferrari, G.M., Ophuis, T.O., Jukema, J., White, H., Pedersen, T., Britto, F., Ruzyllo, W., Carrageta, M., Duris, T., Dalby, A., Seung, K.B., Lopez-Sendon, J., Dellborg, M., Mach, F., Guneri, S., Parkhomenko, A., Brady, A., Cannon, C., Blazing, M., Ballantyne, C., de Lemos, J., Kleiman, N., McGuire, D.K., Centeno, E., Casalins, M., Cartasegna, L., Beltrano, M.C., Guerrero, R., Fanuele, M., Berra, F., Egido, J., Colombo, H., Dellatorre, M., Terns, P., Blumberg, E., Reges, P., Azize, G., Ramos, H., Fernandez, R., Carlessi, C., Milesi, R., Schmuck, R., Duronto, E., Procopio, G., Carlevaro, O., Maffeo, H., Beloscar, J., Viso, M., Hominal, M., Castoldi, M., Bluguermann, J., Mauro, D., Macin, S., Cocco, N., Ruiz, N., Ricart, J., Lozada, A., Nani, S., Turri, D., Fernandez, H., Caruso, O., Zarandon, R., Bono, J., Arias, V., Allall, O., Marino, J., Cusimano, S., Schygiel, P., Buzetti, C., Penaloza, N., Berli, M., Worthley, S., Roach, A., Chew, D., Wright, T., Leitch, J., Hicks, E., Rankin, J., Venn-Edmonds, C., Lehman, R., Morrison, H., Shaw, J., Mak, V., Hii, C., Smith, K., Cross, D., Lilwall, L., Nelson, G., Loxton, A., Horowitz, J., Rose, J., Steinwender, C., Leisch, F., Kammler, J., Brussee, H., Zweiker, R., Niederl, E., Weihs, W., Giorgio, G., Lang, I., Drexel, H., Zanolin, D., Hoppe, U., Atzenhofer-Baumgartner, K., Pichler, M., Hainzer, D., Eber, B., Pichler, F., Foeger, B., Wechselberger, T., Mayr, H., Hofer, J., Stockenhuber, F., Warlits, B., Huber, K., Egger, F., Weidinger, F., Ziegler, B., Jirak, P., Metzler, B., Pachinger, O., Wanitschek, M., Auer, J., Grabscheit, G., Podczeck-Schweighofer, A., Priesnitz, T., Frank, H., El Allaf, D., Marechal, P., Roosen, J., Joly, E., Lefebvre, P., Arend, C., Sinnaeve, P., De Velder, L., Hellemans, S., Vanhauwaert, B., Van Dorpe, A., Heyse, A., Vantomme, C., Striekwold, H., Van Den Broeck, D., Lancellotti, P., Schoors, D., Lemoine, I., Taeymans, Y., De Wolf, L., Brike, C., Vercauteren, S., Tahon, S., Vervoort, G., Mestdagh, I., Pirenne, B., Cardinal, F., Lips, S., Dujardin, K., Debrouwer, K., Dhooghe, G., Holvoet, G., van de Borne, P., Renard, M., De Clippel, M., Lesseliers, H., Van Miert, N., Saraiva, J., Vicente, C., Rossi, P., Dos Santos, L.B., Duda, N., Tognon, A.P., Serrano, C., Gomes, F.L., Manenti, E.R., Silveira, D.S., Maia, L., Mouco, O.M., Paiva, M., Antonangelo, A., de Souza, J., Lino, E.A., Leães, P., Blacher, M.G., Kormann, A., Ultramari, F.T., Dutra, O., Mendelski, A.M., Morgado, S., Ardito, W., Greque, G., Ardito, R.V., Pimentel Filho, P., Zucchetti, C., Alves, A., Seabra, A.M., Mattos, M., Miranda, L.F., Silva, D., Uehara, R.M., Marin Neto, J., Schmidt, A., Braga, J., Rodrigues, A., Abrantes, J., Pinheiro, L., Bodanese, L., Magedanz, É.H., Piegas, L., Dos Santos, E.S., Wainstein, M., Ribeiro, J., Stein, R., Marino, R., Machado, V.M., Moraes Junior, J., Guimarães, S., da Costa, F.A., Ferraz, R.F., Albuquerque, D., Rocha, R.M., de Carvalho Moreira, R., Dohmann, H., Costantini, C., Tarastchuk, J.C., Coelho, O., Cirillo, W., Sousa, A., Almeira, A.S., Stefanini, E., Silva, F., Teixeira, M., da Cunha, C., Précoma, D., Facchi, T.L., Rupka, D., Thiessen, S., Warnica, J., Smith, B., Della Siega, A., Klinke, P., Nelson, S., Dion, D., Gilbert, N., Hui, W., Kvill, L., Sussex, B., Luther, A., Dupuis, R., Ouimet, F., Pandey, A., Clarus, S., Senaratne, M., Ferdinandis, H., Mukherjee, A., Bozek, B., Vizel, S., Markov, G., Zimmermann, R., Stephens, W., Tremblay, B., Wong, G., Uchida, N., Brossoit, R., Peck, C., Van Kieu, C., Forgione, M., Bata, I., Cossett, J., Kostuk, W., Arnold, M., Bone, C., Grondin, F., Bilodeau, N., 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Abstract: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization (≥30 days after randomization), or nonfatal stroke. The median follow-up was 6 years. The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (P<0.001). The Kaplan-Meier event rate for the primary end point at 7 years was 32.7% in the simvastatin-ezetimibe group, as compared with 34.7% in the simvastatin-monotherapy group (absolute risk difference, 2.0 percentage points; hazard ratio, 0.936; 95% confidence interval, 0.89 to 0.99; P=0.016). Rates of prespecified muscle, gallbladder, and hepatic adverse effects and cancer were similar in the two groups. When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benef
Published: 2015

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