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6. AGS and NIA bench-to bedside conference summary: Cancer and cardiovascular disease.

Author

Mohile, Supriya, Blaum, Caroline, Abadir, Peter, Dale, William, Forman, Daniel, Fung, Chunkit, Holmes, Holly, Moslehi, Javid, Mustian, Karen, Rich, Michael, and Whitson, Heather

Subjects
aging, cancer, cardiotoxicity, cardiovascular disease, Aged, Cardiovascular Diseases, Geriatrics, Humans, National Institute on Aging (U.S.), Neoplasms, Risk Factors, United States
Abstract

This report summarizes the presentations, discussions, and recommendations of the most recent American Geriatrics Society and National Institute on Aging research conference, Cancer and Cardiovascular Disease, on October 18-19, 2021. The purpose of this virtual meeting was to address the interface between cancer and heart disease, which are the two leading causes of death among older Americans. Age-related physiologic changes are implicated in the pathogenesis of both conditions. Emerging data suggest that cancer-related cardiovascular disease (CVD) involves disrupted cell signaling and cellular senescence. The risk factors for CVD are also risk factors for cancer and an increased likelihood of cancer death, and people who have both cancer and CVD do more poorly than those who have only cancer or only CVD. Issues addressed in this bench-to-bedside conference include mechanisms of cancer and CVD co-development in older adults, cardiotoxic effects of cancer therapy, and management of comorbid cancer and CVD. Presenters discussed approaches to ensure equitable access to clinical trials and health care for diverse populations of adults with CVD and cancer, mechanisms of cancer therapy cardiotoxicity, and management of comorbid CVD and cancer, including the role of patient values and preferences in treatment decisions. Workshop participants identified many research gaps and questions that could lead to an enhanced understanding of comorbid CVD and cancer and to better and more equitable management strategies.

Published
2022

9. Exercise and epigenetic ages in older adults with myeloid malignancies

Author

Loh, Kah Poh, Sanapala, Chandrika, Jensen-Battaglia, Marielle, Rana, Anish, Sohn, Michael B., Watson, Erin, Gilmore, Nikesha, Klepin, Heidi D., Mendler, Jason H., Liesveld, Jane, Huselton, Eric, LoCastro, Marissa, Susiarjo, Martha, Netherby-Winslow, Colleen, Williams, AnnaLynn M., Mustian, Karen, Vertino, Paula, and Janelsins, Michelle C.

Published
2023
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14. Barriers to participation in clinical trials of rural older adult cancer survivors: A qualitative study

Author

Arana‐Chicas, Evelyn, primary, Prisco, Laura M. Hincapie, additional, Sharma, Saloni, additional, Stauffer, Fiona, additional, Dauphin, Serge, additional, Ban‐Hoefen, Makiko, additional, Navarette, Jaime, additional, Zittel, Jason, additional, Cupertino, Ana Paula, additional, Magnuson, Allison, additional, Mustian, Karen M., additional, and Mohile, Supriya G., additional

Published
2024
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18. Cancer-Related Fatigue

Author

Lin, Po-Ju, Belcher, Elizabeth K., Gilmore, Nikesha J., Hardy, Sara J., Xu, Huiwen, Mustian, Karen M., Kimmick, Gretchen G., editor, Shelby, Rebecca A., editor, and Sutton, Linda M., editor

Published
2021
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20. Mean of Daily Versus Single Week Recall-Based Pain Quality Assessments in Painful Chemotherapy-induced Peripheral Neuropathy (CIPN) Trials: Implications for Assay Sensitivity

Author

Rangel, Madelaine S., primary, Besharat, Soroush, additional, Sohn, Michael B., additional, Burnette, Brian, additional, Francar, Lori, additional, Jorgensen, Carla, additional, Mustian, Karen, additional, Morrow, Gary, additional, Dermott, Michael P. Mc, additional, Jensen, Mark, additional, and Gewandter, Jennifer S., additional

Published
2024
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21. Pilot trial testing the effects of exercise on chemotherapy-induced peripheral neurotoxicity (CIPN) and the interoceptive brain system

Author

Kleckner, Ian R., primary, Manuweera, Thushini, additional, Lin, Po-Ju, additional, Chung, Kaitlin H., additional, Kleckner, Amber S., additional, Gewandter, Jennifer S., additional, Culakova, Eva, additional, Tivarus, Madalina E., additional, Dunne, Richard F., additional, Loh, Kah Poh, additional, Mohile, Nimish A., additional, Kesler, Shelli R., additional, and Mustian, Karen M., additional

Published
2024
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22. Evaluation of geriatric assessment and management on the toxic effects of cancer treatment (GAP70+): a cluster-randomised study

Author

Mohile, Supriya G, Mohamed, Mostafa R, Xu, Huiwen, Culakova, Eva, Loh, Kah Poh, Magnuson, Allison, Flannery, Marie A, Obrecht, Spencer, Gilmore, Nikesha, Ramsdale, Erika, Dunne, Richard F, Wildes, Tanya, Plumb, Sandy, Patil, Amita, Wells, Megan, Lowenstein, Lisa, Janelsins, Michelle, Mustian, Karen, Hopkins, Judith O, Berenberg, Jeffrey, Anthony, Navin, and Dale, William

Published
2021
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24. Caregiving burden of informal caregivers of older adults with advanced cancer: The effects of rurality and education

Author

Xu, Huiwen, Kadambi, Sindhuja, Mohile, Supriya G., Yang, Shuhan, Kehoe, Lee A., Wells, Megan, Culakova, Eva, Kamen, Charles, Obrecht, Spencer, Mohamed, Mostafa, Gilmore, Nikesha J., Magnuson, Allison, Grossman, Valerie Aarne, Hopkins, Judith O., Geer, Jodi, Berenberg, Jeffrey, Mustian, Karen, Cupertino, Anapaula, Mohile, Nimish, and Loh, Kah Poh

Published
2021
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29. High‐dose vitamin D to attenuate bone loss in patients with prostate cancer on androgen deprivation therapy: A phase 2 RCT.

Author

Peppone, Luke J., Kleckner, Amber S., Fung, Chunkit, Puzas, J. Edward, Reschke, Jennifer E., Culakova, Eva, Inglis, Julia, Kamen, Charles, Friedberg, Jonathan W., Janelsins, Michelle, Mustian, Karen, Heckler, Charles E., and Mohile, Supriya

Subjects
FEMUR neck, ANDROGEN deprivation therapy, PROSTATE cancer patients, BONE density, DUAL-energy X-ray absorptiometry, BONE growth, TERIPARATIDE, ANDROGEN receptors
Abstract

Background: Androgen deprivation therapy (ADT) inhibits prostate cancer growth. However, ADT causes loss of bone mineral density (BMD) and an increase in fracture risk; effective interventions for ADT‐induced bone loss are limited. Methods: A phase 2 randomized controlled trial investigated the feasibility, safety, and preliminary efficacy of high‐dose weekly vitamin D (HDVD, 50,000 IU/week) versus placebo for 24 weeks in patients with prostate cancer receiving ADT, with all subjects receiving 600 IU/day vitamin D and 1000 mg/day calcium. Participants were ≥60 years (mean years, 67.7), had a serum 25‐hydroxyvitamin D level <32 ng/mL, and initiated ADT within the previous 6 months. At baseline and after intervention, dual‐energy x‐ray absorptiometry was used to assess BMD, and levels of bone cell, bone formation, and resorption were measured. Results: The HDVD group (N = 29) lost 1.5% BMD at the total hip vs. 4.1% for the low‐dose group (N = 30; p =.03) and 1.7% BMD at the femoral neck vs. 4.4% in the low‐dose group (p =.06). Stratified analyses showed that, for those with baseline 25‐hydroxyvitamin D level <27 ng/mL, the HDVD group lost 2.3% BMD at the total hip vs 7.1% for the low‐dose group (p <.01). Those in the HDVD arm showed significant changes in parathyroid hormone (p <.01), osteoprotegerin (p < 0.01), N‐terminal telopeptide of type 1 collagen (p < 0.01) and C‐terminal telopeptide of type 1 collagen (p < 0.01). No difference in adverse events or toxicity was noted between the groups. Conclusions: HDVD supplementation significantly reduced hip and femoral neck BMD loss, especially for patients with low baseline serum 25‐hydroxyvitamin D levels, although demonstrating safety and feasibility in prostate cancer patients on ADT. Patients with prostate cancer on androgen deprivation therapy often suffer rapid bone loss during the initiation of treatment. Supplementation with high‐dose vitamin D (50,000 IU/week plus 800 IU/day) significantly and safely decreased the amount of bone loss compared with vitamin D supplementation using the recommended daily allowance (800 IU/day). [ABSTRACT FROM AUTHOR]

Published
2024
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32. A Whole-Food, Plant-Based Randomized Controlled Trial in Metastatic Breast Cancer: Weight, Cardiometabolic, and Hormonal Outcome

Author

Campbell, Thomas M, primary, Campbell, Erin K, additional, Culakova, Eva, additional, Blanchard, Lisa, additional, Wixom, Nellie, additional, Guido, Joseph, additional, Fetten, James, additional, Huston, Alissa, additional, Shayne, Michelle, additional, Janelsins, Michelle C, additional, Mustian, Karen M, additional, Moore, Richard G, additional, and Peppone, Luke J, additional

Published
2023
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33. Wireless transcutaneous electric nerve stimulation (TENS) for chronic chemotherapy-induced peripheral neuropathy (CIPN): a proof-of-concept randomized clinical trial

Author

Gewandter, Jennifer S., primary, Culakova, Eva, additional, Davis, Jenae N., additional, Gada, Umang, additional, Guido, Joseph J., additional, Bearden, James D., additional, Burnette, Brain, additional, Shah, Dhaval, additional, Morrow, Gary, additional, Mustian, Karen, additional, Sluka, Kathleen, additional, and Mohile, Nimish, additional

Published
2023
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34. 490 DiRECT Cohort: An NCORP longitudinal observational trial for disparities in results of immune checkpoint inhibitor treatment between Black and White cancer patients

Author

Yao, Song, primary, Ambrosone, Christine B, additional, Sakoda, Lori, additional, PuzanovCI, Igor, additional, Culakova, Eva, additional, Janelsins, Michelle, additional, Davis, Warren, additional, Khoury, Thaer, additional, Rodriguez, Elisa, additional, Gandhi, Shipra, additional, Magnuson, Allison, additional, Cantuaria, Guilherme, additional, Suga, Jennifer M, additional, Chowdry, Rajasree P, additional, Kushi, Lawrence H, additional, Mustian, Karen, additional, Morrow, Gary R, additional, and Kamen, Charles, additional

Published
2023
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38. The biology of cancer-related fatigue: a review of the literature

Author

Saligan, Leorey N, Olson, Karin, Filler, Kristin, Larkin, David, Cramp, Fiona, Sriram, Yennu, Escalante, Carmen P, del Giglio, Auro, Kober, Kord M, Kamath, Jayesh, Palesh, Oxana, Mustian, Karen, and Multinational Association of Supportive Care in Cancer Fatigue Study Group–Biomarker Working Group

Subjects
Health Services and Systems, Nursing, Health Sciences, Cancer, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Cross-Sectional Studies, Fatigue, Female, Humans, Longitudinal Studies, Male, Neoplasms, Surveys and Questionnaires, Cancer-related fatigue, Inflammation, Metabolic, Neuroendocrine, Genetic, Multinational Association of Supportive Care in Cancer Fatigue Study Group-Biomarker Working Group, Medical and Health Sciences, Psychology and Cognitive Sciences, Oncology & Carcinogenesis, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

PurposeUnderstanding the etiology of cancer-related fatigue (CRF) is critical to identify targets to develop therapies to reduce CRF burden. The goal of this systematic review was to expand on the initial work by the National Cancer Institute CRF Working Group to understand the state of the science related to the biology of CRF and, specifically, to evaluate studies that examined the relationships between biomarkers and CRF and to develop an etiologic model of CRF to guide researchers on pathways to explore or therapeutic targets to investigate.MethodsThis review was completed by the Multinational Association of Supportive Care in Cancer Fatigue Study Group-Biomarker Working Group. The initial search used three terms (biomarkers, fatigue, cancer), which yielded 11,129 articles. After removing duplicates, 9145 articles remained. Titles were assessed for the keywords "cancer" and "fatigue" resulting in 3811 articles. Articles published before 2010 and those with samples

Published
2015

39. Same-Sex Couples Matter in Cancer Care

Author

Kamen, Charles, Mustian, Karen, Johnson, Mallory O, and Boehmer, Ulrike

Subjects
Cancer, Reproductive health and childbirth, Good Health and Well Being, Family Characteristics, Health Services Accessibility, Homosexuality, Humans, Minority Groups, Neoplasms, United States
Abstract

The authors hope this discussion will spark interest in examining the process of coping with cancer among sexual minority individuals and same-sex couples and lead to enhanced services for this underserved and underrepresented group.

Published
2015

40. Fatigue

Author

Mustian, Karen M., Lin, Po-Ju, Loh, Kah Poh, Kleckner, Ian R., Feuerstein, Michael, editor, and Nekhlyudov, Larissa, editor

Published
2018
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45. Recommendations for High-Priority Research on Cancer-Related Fatigue in Children and Adults

Author

Barsevick, Andrea M, Irwin, Michael R, Hinds, Pamela, Miller, Andrew, Berger, Ann, Jacobsen, Paul, Ancoli-Israel, Sonia, Reeve, Bryce B, Mustian, Karen, O’Mara, Ann, Lai, Jin-Shei, Fisch, Michael, and Cella, David

Subjects
Clinical Trials and Supportive Activities, Cancer, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Adult, Anxiety, Benzhydryl Compounds, Bupropion, Central Nervous System Stimulants, Child, Clinical Trials as Topic, Depression, Dopamine Uptake Inhibitors, Exercise, Fatigue, Female, Humans, Male, Modafinil, Motor Activity, National Cancer Institute (U.S.), Neoplasms, Patient Satisfaction, Research Design, Risk Factors, Sleep Deprivation, Treatment Outcome, United States, National Cancer Institute Clinical Trials Planning Meeting, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Over the past decades, some scientific progress has been made in understanding and treating cancer-related fatigue (CRF). However, three major problems have limited further progress: lack of agreement about measurement, inadequate understanding of the underlying biology, and problems in the conduct of clinical trials for CRF. This commentary reports the recommendations of a National Cancer Institute Clinical Trials Planning Meeting and an ongoing National Cancer Institute working group to address these problems so that high-priority research and clinical trials can be conducted to advance the science of CRF and its treatment. Recommendations to address measurement issues included revising the current case definition to reflect more rigorous criteria, adopting the Patient Reported Outcomes Measurement Information System fatigue scales as standard measures of CRF, and linking legacy measures to the scales. With regard to the biology of CRF, the group identified the need for longitudinal research to examine biobehavioral mechanisms underlying CRF and testing mechanistic hypotheses within the context of intervention research. To address clinical trial issues, recommendations included using only placebo-controlled trial designs. setting eligibility to minimize sample heterogeneity or enable subgroup analysis, establishing a CRF severity threshold for participation in clinical trials, conducting dissemination trials of efficacious interventions (such as exercise), and combining nonpharmacologic and pharmacologic interventions to exploit the potential synergy between these approaches. Accomplishing these goals has the potential to advance the science of CRF and improve the clinical management of this troubling symptom.

Published
2013

49. Novel Biomarkers Of Treatment-Induced Muscle Damage, Exercise And Fatigue: An RCT In Breast Cancer Patients: 3540 Board #361 May 29 2:30 PM - 4:00 PM

Author

Mustian, Karen M., Lin, Po-Ju, Culakova, Eva, Colasurdo, Ann, Dunne, Richard F., Fung, Chunkit, Gilmore, Nikesha J., Heckler, Charles E., Inglis, Julia E., Janelsins, Michelle C., Kamen, Charles S., Kleckner, Amber S., Kleckner, Ian R., Loh, Kah Poh, Lopez, Gilberto, Peppone, Luke J., Porto, Michelle, Ramsdale, Erika, and Morrow, Gary

Published
2020
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