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1. Predictors of Food Sensitization in Children and Adults Across Europe

Author

Lyons, Sarah A., Knulst, André C., Burney, Peter G.J., Fernández-Rivas, Montserrat, Ballmer-Weber, Barbara K., Barreales, Laura, Bieli, Christian, Clausen, Michael, Dubakiene, Ruta, Fernández-Perez, Cristina, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L., Kummeling, Ischa, Mustakov, Tihomir B., van Os-Medendorp, Harmieke, Papadopoulos, Nikolaos G., Popov, Todor A., Potts, James, Xepapadaki, Paraskevi, Welsing, Paco M.J., Mills, E. N. Clare, van Ree, Ronald, and Le, Thuy-My

Published
2020
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2. Prevalence of Food Sensitization and Food Allergy in Children Across Europe

Author

Lyons, Sarah A., Clausen, Michael, Knulst, André C., Ballmer-Weber, Barbara K., Fernandez-Rivas, Montserrat, Barreales, Laura, Bieli, Christian, Dubakiene, Ruta, Fernandez-Perez, Cristina, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L., Kralimarkova, Tanya, Kummeling, Ischa, Mustakov, Tihomir B., Papadopoulos, Nikolaos G., Popov, Todor A., Xepapadaki, Paraskevi, Welsing, Paco M.J., Potts, James, Mills, E.N. Clare, van Ree, Ronald, Burney, Peter G.J., and Le, Thuy-My

Published
2020
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3. Food Allergy in Adults: Substantial Variation in Prevalence and Causative Foods Across Europe

Author

Lyons, Sarah A., Burney, Peter G.J., Ballmer-Weber, Barbara K., Fernandez-Rivas, Montserrat, Barreales, Laura, Clausen, Michael, Dubakiene, Ruta, Fernandez-Perez, Cristina, Fritsche, Philipp, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L., Kralimarkova, Tanya, Kummeling, Ischa, Mustakov, Tihomir B., Lebens, Ans F.M., van Os-Medendorp, Harmieke, Papadopoulos, Nikolaos G., Popov, Todor A., Sakellariou, Alexandros, Welsing, Paco M.J., Potts, James, Mills, E.N. Clare, van Ree, Ronald, Knulst, André C., and Le, Thuy-My

Published
2019
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8. Predicting food allergy: The value of patient history reinforced

Author

Lyons, Sarah A; https://orcid.org/0000-0001-7128-2699, Knulst, André C, Burney, Peter G J, Fernandez-Rivas, Montserrat, Ballmer-Weber, Barbara K, Barreales, Laura, Bieli, Christian, Clausen, Michael, Dubakiene, Ruta, Fernandez-Perez, Cristina, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L; https://orcid.org/0000-0002-8442-2774, Kummeling, Ischa, Kralimarkova, Tanya, Mustakov, Tihomir B, van Os-Medendorp, Harmieke, Papadopoulos, Nikolaos G, Popov, Todor A, Potts, James, Versteeg, Serge A, Xepapadaki, Paraskevi; https://orcid.org/0000-0001-9204-1923, Welsing, Paco M J, Mills, Clare, van Ree, Ronald, Le, Thuy-My, Lyons, Sarah A; https://orcid.org/0000-0001-7128-2699, Knulst, André C, Burney, Peter G J, Fernandez-Rivas, Montserrat, Ballmer-Weber, Barbara K, Barreales, Laura, Bieli, Christian, Clausen, Michael, Dubakiene, Ruta, Fernandez-Perez, Cristina, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L; https://orcid.org/0000-0002-8442-2774, Kummeling, Ischa, Kralimarkova, Tanya, Mustakov, Tihomir B, van Os-Medendorp, Harmieke, Papadopoulos, Nikolaos G, Popov, Todor A, Potts, James, Versteeg, Serge A, Xepapadaki, Paraskevi; https://orcid.org/0000-0001-9204-1923, Welsing, Paco M J, Mills, Clare, van Ree, Ronald, and Le, Thuy-My

Abstract

BACKGROUND: EAACI guidelines emphasize the importance of patient history in diagnosing food allergy (FA) and the need for studies investigating its value using standardized allergy-focused questionnaires. OBJECTIVE: To determine the contribution of reaction characteristics, allergic comorbidities and demographics to prediction of FA in individuals experiencing food-related adverse reactions. METHODS: Adult and school-age participants in the standardized EuroPrevall population surveys, with self-reported FA, were included. Penalized multivariable regression was used to assess the association of patient history determinants with "probable" FA, defined as a food-specific case history supported by relevant IgE sensitization. RESULTS: In adults (N = 844), reproducibility of reaction (OR 1.35 [95% CI 1.29-1.41]), oral allergy symptoms (OAS) (4.46 [4.19-4.75]), allergic rhinitis (AR) comorbidity (2.82 [2.68-2.95]), asthma comorbidity (1.38 [1.30-1.46]) and male sex (1.50 [1.41-1.59]) were positively associated with probable FA. Gastrointestinal symptoms (0.88 [0.85-0.91]) made probable FA less likely. The AUC of a model combining all selected predictors was 0.85 after cross-validation. In children (N = 670), OAS (2.26 [2.09-2.44]) and AR comorbidity (1.47 [CI 1.39-1.55]) contributed most to prediction of probable FA, with a combined cross-validation-based AUC of 0.73. When focusing on plant foods, the dominant source of FA in adults, the pediatric model also included gastrointestinal symptoms (inverse association), and the AUC increased to 0.81. CONCLUSIONS: In both adults and school-age children from the general population, reporting of OAS and of AR comorbidity appear to be the strongest predictors of probable FA. Patient history particularly allows for good discrimination between presence and absence of probable plant FA.

Published
2021

9. Predicting food allergy: the value of patient history reinforced

Author

MS Dermatologie/Allergologie, Infection & Immunity, Afdeling Dermatologie/Allergologie, Lab Reumatologie/Klinische Immunologie, Regenerative Medicine and Stem Cells, JC onderzoeksprogramma Methodologie, Lyons, Sarah A, Knulst, André C, Burney, Peter G J, Fernandez-Rivas, Montserrat, Ballmer-Weber, Barbara K, Barreales, Laura, Bieli, Christian, Clausen, Michael, Dubakiene, Ruta, Fernandez-Perez, Cristina, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L, Kummeling, Ischa, Kralimarkova, Tanya, Mustakov, Tihomir B, van Os-Medendorp, Harmieke, Papadopoulos, Nikolaos G, Popov, Todor A, Potts, James, Versteeg, Serge A, Xepapadaki, Paraskevi, Welsing, Paco M J, Mills, E N Clare, van Ree, Ronald, Le, Thuy-My, MS Dermatologie/Allergologie, Infection & Immunity, Afdeling Dermatologie/Allergologie, Lab Reumatologie/Klinische Immunologie, Regenerative Medicine and Stem Cells, JC onderzoeksprogramma Methodologie, Lyons, Sarah A, Knulst, André C, Burney, Peter G J, Fernandez-Rivas, Montserrat, Ballmer-Weber, Barbara K, Barreales, Laura, Bieli, Christian, Clausen, Michael, Dubakiene, Ruta, Fernandez-Perez, Cristina, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L, Kummeling, Ischa, Kralimarkova, Tanya, Mustakov, Tihomir B, van Os-Medendorp, Harmieke, Papadopoulos, Nikolaos G, Popov, Todor A, Potts, James, Versteeg, Serge A, Xepapadaki, Paraskevi, Welsing, Paco M J, Mills, E N Clare, van Ree, Ronald, and Le, Thuy-My

Published
2021

11. Secondary prevention measures in anaphylaxis patients: Data from the anaphylaxis registry

Author

Kraft, Magdalena, Knop, Macarena Pia, Renaudin, Jean-Marie, Scherer Hofmeier, Kathrin, Pföhler, Claudia, Bilò, Maria Beatrice, Lang, Roland, Treudler, Regina, Wagner, Nicola, Spindler, Thomas, Hourihane, Jonathan O'B, Maris, Ioana, Koehli, Alice, Bauer, Andrea, Lange, Lars, Müller, Sabine, Papadopoulos, Nikolaos G, Wedi, Bettina, Moeser, Anne, Ensina, Luis F, Fernandez-Rivas, Montserrat, Cichocka-Jarosz, Ewa, Christoff, George, Garcia, Blanca E, Poziomkowska-Gęsicka, Iwona, Cardona, Victoria, Mustakov, Tihomir B, Rabe, Uta, Mahler, Vera, Grabenhenrich, Linus, et al, and University of Zurich

Subjects
2403 Immunology, 10036 Medical Clinic, 2723 Immunology and Allergy, 610 Medicine & health
Published
2020

12. Secondary prevention measures in anaphylaxis patients: Data from the anaphylaxis registry

Author

Kraft, Magdalena; https://orcid.org/0000-0002-2770-9947, Knop, Macarena Pia, Renaudin, Jean-Marie, Scherer Hofmeier, Kathrin, Pföhler, Claudia, Bilò, Maria Beatrice, Lang, Roland, Treudler, Regina, Wagner, Nicola, Spindler, Thomas, Hourihane, Jonathan O'B, Maris, Ioana, Koehli, Alice, Bauer, Andrea, Lange, Lars; https://orcid.org/0000-0003-1104-5848, Müller, Sabine, Papadopoulos, Nikolaos G, Wedi, Bettina; https://orcid.org/0000-0002-9868-6308, Moeser, Anne, Ensina, Luis F, Fernandez-Rivas, Montserrat, Cichocka-Jarosz, Ewa, Christoff, George, Garcia, Blanca E, Poziomkowska-Gęsicka, Iwona, Cardona, Victoria; https://orcid.org/0000-0003-2197-9767, Mustakov, Tihomir B, Rabe, Uta, Mahler, Vera, Grabenhenrich, Linus, et al, Kraft, Magdalena; https://orcid.org/0000-0002-2770-9947, Knop, Macarena Pia, Renaudin, Jean-Marie, Scherer Hofmeier, Kathrin, Pföhler, Claudia, Bilò, Maria Beatrice, Lang, Roland, Treudler, Regina, Wagner, Nicola, Spindler, Thomas, Hourihane, Jonathan O'B, Maris, Ioana, Koehli, Alice, Bauer, Andrea, Lange, Lars; https://orcid.org/0000-0003-1104-5848, Müller, Sabine, Papadopoulos, Nikolaos G, Wedi, Bettina; https://orcid.org/0000-0002-9868-6308, Moeser, Anne, Ensina, Luis F, Fernandez-Rivas, Montserrat, Cichocka-Jarosz, Ewa, Christoff, George, Garcia, Blanca E, Poziomkowska-Gęsicka, Iwona, Cardona, Victoria; https://orcid.org/0000-0003-2197-9767, Mustakov, Tihomir B, Rabe, Uta, Mahler, Vera, Grabenhenrich, Linus, and et al

Abstract

BACKGROUND Patients with a history of anaphylaxis are at risk of future anaphylactic reactions. Thus, secondary prevention measures are recommended for these patients to prevent or attenuate the next reaction. METHODS Data from the Anaphylaxis Registry were analyzed to identify secondary prevention measures offered to patients who experienced anaphylaxis. Our analysis included 7788 cases from 10 European countries and Brazil. RESULTS The secondary prevention measures offered varied across the elicitors. A remarkable discrepancy was observed between prevention measures offered in specialized allergy centers (84% of patients were prescribed adrenaline autoinjectors following EAACI guidelines) and outside the centers: Here, EAACI guideline adherence was only 37%. In the multivariate analysis, the elicitor of the reaction, age of the patient, mastocytosis as comorbidity, severity of the reaction, and reimbursement/availability of the autoinjector influence physician's decision to prescribe one. CONCLUSIONS Based on the low implementation of guidelines concerning secondary prevention measures outside of specialized allergy centers, our findings highlight the importance of these specialized centers and the requirement of better education for primary healthcare and emergency physicians.

Published
2020

13. Prevalence of food sensitization and food allergy in children across Europe

Author

Lyons, Sarah A, Clausen, Michael, Knulst, André C, Ballmer-Weber, Barbara K, Fernandez-Rivas, Montserrat, Barreales, Laura, Bieli, Christian, Dubakiene, Ruta, Fernandez-Perez, Cristina, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L, Kralimarkova, Tanya, Kummeling, Ischa, Mustakov, Tihomir B, Papadopoulos, Nikolaos G, Popov, Todor A, Xepapadaki, Paraskevi, Welsing, Paco M J, Potts, James, Mills, E N Clare, van Ree, Ronald, Burney, Peter G J, Le, Thuy-My, Lyons, Sarah A, Clausen, Michael, Knulst, André C, Ballmer-Weber, Barbara K, Fernandez-Rivas, Montserrat, Barreales, Laura, Bieli, Christian, Dubakiene, Ruta, Fernandez-Perez, Cristina, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L, Kralimarkova, Tanya, Kummeling, Ischa, Mustakov, Tihomir B, Papadopoulos, Nikolaos G, Popov, Todor A, Xepapadaki, Paraskevi, Welsing, Paco M J, Potts, James, Mills, E N Clare, van Ree, Ronald, Burney, Peter G J, and Le, Thuy-My

Abstract

BACKGROUND: For adults, prevalence estimates of food sensitization (FS) and food allergy (FA) have been obtained in a standardized manner across Europe. For children, such estimates are lacking. OBJECTIVES: To determine the prevalence of self-reported FA, FS, probable FA (symptoms plus IgE sensitization), and challenge-confirmed FA in European school-age children. METHODS: Data on self-reported FA were collected through a screening questionnaire sent to a random sample of the general population of 7- to 10-year-old children in 8 European centers in phase I of the EuroPrevall study. Data on FS and probable FA were obtained in phase II, comprising an extensive questionnaire on reactions to 24 commonly implicated foods, and serology testing. Food challenge was performed in phase III. RESULTS: Prevalence (95% CI) of self-reported FA ranged from 6.5% (5.4-7.6) in Athens to 24.6% (22.8-26.5) in Lodz; prevalence of FS ranged from 11.0% (9.7-12.3) in Reykjavik to 28.7% (26.9-30.6) in Zurich; and prevalence of probable FA ranged from 1.9% (0.8-3.5) in Reykjavik to 5.6% (3.6-8.1) in Lodz. In all centers, most food-sensitized subjects had primary (non-cross-reactive) FS. However, FS due to birch pollen related cross-reactivity was also common in Central-Northern Europe. Probable FA to milk and egg occurred frequently throughout Europe; to fish and shrimp mainly in the Mediterranean and Reykjavik. Peach, kiwi, and peanut were prominent sources of plant FA in most countries, along with notably hazelnut, apple, carrot, and celery in Central-Northern Europe and lentils and walnut in the Mediterranean. CONCLUSIONS: There are large geograhical differences in the prevalence of FS and FA in school-age children across Europe. Both primary and cross-reactive FS and FA occur frequently.

Published
2020

14. Predictors of food sensitization in children and adults across Europe

Author

Lyons, Sarah A, Knulst, André C, Burney, Peter G J, Fernández-Rivas, Montserrat, Ballmer-Weber, Barbara K, Barreales, Laura, Bieli, Christian, Clausen, Michael, Dubakiene, Ruta, Fernández-Perez, Cristina, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L, Kummeling, Ischa, Mustakov, Tihomir B, van Os-Medendorp, Harmieke, Papadopoulos, Nikolaos G, Popov, Todor A, Potts, James, Xepapadaki, Paraskevi, Welsing, Paco M J, Mills, E N Clare, van Ree, Ronald, Le, Thuy-My, Lyons, Sarah A, Knulst, André C, Burney, Peter G J, Fernández-Rivas, Montserrat, Ballmer-Weber, Barbara K, Barreales, Laura, Bieli, Christian, Clausen, Michael, Dubakiene, Ruta, Fernández-Perez, Cristina, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L, Kummeling, Ischa, Mustakov, Tihomir B, van Os-Medendorp, Harmieke, Papadopoulos, Nikolaos G, Popov, Todor A, Potts, James, Xepapadaki, Paraskevi, Welsing, Paco M J, Mills, E N Clare, van Ree, Ronald, and Le, Thuy-My

Abstract

BACKGROUND: The geographical variation and temporal increase in the prevalence of food sensitization (FS) suggest environmental influences. OBJECTIVE: To investigate how environment, infant diet, and demographic characteristics, are associated with FS in children and adults, focusing on early-life exposures. METHODS: Data on childhood and adult environmental exposures (including, among others, sibship size, daycare, pets, farm environment, and smoking), infant diet (including breastfeeding and timing of introduction to infant formula and solids), and demographic characteristics were collected from 2196 school-age children and 2185 adults completing an extensive questionnaire and blood sampling in the cross-sectional pan-European EuroPrevall project. Multivariable logistic regression was applied to determine associations between the predictor variables and sensitization to foods commonly implicated in food allergy (specific IgE ≥0.35 kU$_{A}$/L). Secondary outcomes were inhalant sensitization and primary (non-cross-reactive) FS. RESULTS: Dog ownership in early childhood was inversely associated with childhood FS (odds ratio, 0.65; 95% CI, 0.48-0.90), as was higher gestational age at delivery (odds ratio, 0.93 [95% CI, 0.87-0.99] per week increase in age). Lower age and male sex were associated with a higher prevalence of adult FS (odds ratio, 0.97 [95% CI, 0.96-0.98] per year increase in age, and 1.39 [95% CI, 1.12-1.71] for male sex). No statistically significant associations were found between other evaluated environmental determinants and childhood or adult FS, nor between infant diet and childhood FS, although early introduction of solids did show a trend toward prevention of FS. CONCLUSIONS: Dog ownership seems to protect against childhood FS, but independent effects of other currently conceived environmental and infant dietary determinants on FS in childhood or adulthood could not be confirmed.

Published
2020

15. Prevalence of Food Sensitization and Food Allergy in Children across Europe

Author

MS Dermatologie/Allergologie, Infection & Immunity, DIGD-Onderzoek, Lyons, Sarah A, Clausen, Michael, Knulst, André C, Ballmer-Weber, Barbara K, Fernandez-Rivas, Montserrat, Barreales, Laura, Bieli, Christian, Dubakiene, Ruta, Fernandez-Perez, Cristina, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L, Kralimarkova, Tanya, Kummeling, Ischa, Mustakov, Tihomir B, Papadopoulos, Nikolaos G, Popov, Todor A, Xepapadaki, Paraskevi, Welsing, Paco M J, Potts, James, Mills, E N Clare, van Ree, Ronald, Burney, Peter G J, Le, Thuy-My, MS Dermatologie/Allergologie, Infection & Immunity, DIGD-Onderzoek, Lyons, Sarah A, Clausen, Michael, Knulst, André C, Ballmer-Weber, Barbara K, Fernandez-Rivas, Montserrat, Barreales, Laura, Bieli, Christian, Dubakiene, Ruta, Fernandez-Perez, Cristina, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L, Kralimarkova, Tanya, Kummeling, Ischa, Mustakov, Tihomir B, Papadopoulos, Nikolaos G, Popov, Todor A, Xepapadaki, Paraskevi, Welsing, Paco M J, Potts, James, Mills, E N Clare, van Ree, Ronald, Burney, Peter G J, and Le, Thuy-My

Published
2020

16. Predictors of Food Sensitization in Children and Adults across Europe

Author

MS Dermatologie/Allergologie, Infection & Immunity, Afdeling Dermatologie/Allergologie, DIGD-Onderzoek, Lyons, Sarah A, Knulst, André C, Burney, Peter G J, Fernández-Rivas, Montserrat, Ballmer-Weber, Barbara K, Barreales, Laura, Bieli, Christian, Clausen, Michael, Dubakiene, Ruta, Fernández-Perez, Cristina, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L, Kummeling, Ischa, Mustakov, Tihomir B, van Os-Medendorp, Harmieke, Papadopoulos, Nikolaos G, Popov, Todor A, Potts, James, Xepapadaki, Paraskevi, Welsing, Paco M J, Mills, E N Clare, van Ree, Ronald, Le, Thuy-My, MS Dermatologie/Allergologie, Infection & Immunity, Afdeling Dermatologie/Allergologie, DIGD-Onderzoek, Lyons, Sarah A, Knulst, André C, Burney, Peter G J, Fernández-Rivas, Montserrat, Ballmer-Weber, Barbara K, Barreales, Laura, Bieli, Christian, Clausen, Michael, Dubakiene, Ruta, Fernández-Perez, Cristina, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L, Kummeling, Ischa, Mustakov, Tihomir B, van Os-Medendorp, Harmieke, Papadopoulos, Nikolaos G, Popov, Todor A, Potts, James, Xepapadaki, Paraskevi, Welsing, Paco M J, Mills, E N Clare, van Ree, Ronald, and Le, Thuy-My

Published
2020

17. Secondary prevention measures in anaphylaxis patients: Data from the anaphylaxis registry

Author

Kraft, Magdalena, Knop, Macarena Pia, Renaudin, Jean-Marie, Scherer Hofmeier, Kathrin, Pföhler, Claudia, Bilò, Maria Beatrice, Lang, Roland, Treudler, Regina, Wagner, Nicola, Spindler, Thomas, O'B Hourihane, Jonathan, Maris, Ioana, Koehli, Alice, Bauer, Andrea, Lange, Lars, Müller, Sabine, Papadopoulos, Nikolaos G., Wedi, Bettina, Moeser, Anne, Ensina, Luis F., Fernandez-Rivas, Montserrat, Cichocka-Jarosz, Ewa, Christoff, George, Garcia, Blanca E., Poziomkowska-Gęsicka, Iwona, Cardona, Victoria, Mustakov, Tihomir B., Rabe, Uta, Mahler, Vera, Grabenhenrich, Linus, Dölle-Bierke, Sabine, Worm, Margitta, and The Network for Online Registration of Anaphylaxis (NORA)

Subjects
epinephrine autoinjector, adrenaline autoinjector, anaphylaxis, ddc:610, 610 Medizin und Gesundheit, secondary prevention, anaphylactic reaction
Abstract

Background Patients with a history of anaphylaxis are at risk of future anaphylactic reactions. Thus, secondary prevention measures are recommended for these patients to prevent or attenuate the next reaction. Methods Data from the Anaphylaxis Registry were analyzed to identify secondary prevention measures offered to patients who experienced anaphylaxis. Our analysis included 7788 cases from 10 European countries and Brazil. Results The secondary prevention measures offered varied across the elicitors. A remarkable discrepancy was observed between prevention measures offered in specialized allergy centers (84% of patients were prescribed adrenaline autoinjectors following EAACI guidelines) and outside the centers: Here, EAACI guideline adherence was only 37%. In the multivariate analysis, the elicitor of the reaction, age of the patient, mastocytosis as comorbidity, severity of the reaction, and reimbursement/availability of the autoinjector influence physician's decision to prescribe one. Conclusions Based on the low implementation of guidelines concerning secondary prevention measures outside of specialized allergy centers, our findings highlight the importance of these specialized centers and the requirement of better education for primary healthcare and emergency physicians.

Published
2019

18. Predicting food allergy: The value of patient history reinforced

Author

Lyons, Sarah A., primary, Knulst, André C., additional, Burney, Peter G. J., additional, Fernandez‐Rivas, Montserrat, additional, Ballmer‐Weber, Barbara K., additional, Barreales, Laura, additional, Bieli, Christian, additional, Clausen, Michael, additional, Dubakiene, Ruta, additional, Fernandez‐Perez, Cristina, additional, Jedrzejczak‐Czechowicz, Monika, additional, Kowalski, Marek L., additional, Kummeling, Ischa, additional, Kralimarkova, Tanya, additional, Mustakov, Tihomir B., additional, Os‐Medendorp, Harmieke, additional, Papadopoulos, Nikolaos G., additional, Popov, Todor A., additional, Potts, James, additional, Versteeg, Serge A., additional, Xepapadaki, Paraskevi, additional, Welsing, Paco M. J., additional, Mills, Clare, additional, Ree, Ronald, additional, and Le, Thuy‐My, additional

Published
2020
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20. Food Allergy in Adults: Substantial Variation in Prevalence and Causative Foods Across Europe

Author

UMC Utrecht, MS Dermatologie/Allergologie, Afdeling Dermatologie/Allergologie, Infection & Immunity, Lab Reumatologie/Klinische Immunologie, Regenerative Medicine and Stem Cells, JC onderzoeksprogramma Methodologie, Lyons, Sarah A., Burney, Peter G.J., Ballmer-Weber, Barbara K., Fernandez-Rivas, Montserrat, Barreales, L., Clausen, Michael, Dubakiene, Ruta, Fernandez-Perez, Cristina, Fritsche, Philipp, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L., Kralimarkova, T., Kummeling, I., Mustakov, Tihomir B., Lebens, Ans F.M., van Os-Medendorp, Harmieke, Papadopoulos, Nikolaos G., Popov, Todor A., Sakellariou, Alexandros, Welsing, Paco M.J., Potts, J., Mills, E. N.Clare, van Ree, Ronald, Knulst, André C., Le, Thuy My, UMC Utrecht, MS Dermatologie/Allergologie, Afdeling Dermatologie/Allergologie, Infection & Immunity, Lab Reumatologie/Klinische Immunologie, Regenerative Medicine and Stem Cells, JC onderzoeksprogramma Methodologie, Lyons, Sarah A., Burney, Peter G.J., Ballmer-Weber, Barbara K., Fernandez-Rivas, Montserrat, Barreales, L., Clausen, Michael, Dubakiene, Ruta, Fernandez-Perez, Cristina, Fritsche, Philipp, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L., Kralimarkova, T., Kummeling, I., Mustakov, Tihomir B., Lebens, Ans F.M., van Os-Medendorp, Harmieke, Papadopoulos, Nikolaos G., Popov, Todor A., Sakellariou, Alexandros, Welsing, Paco M.J., Potts, J., Mills, E. N.Clare, van Ree, Ronald, Knulst, André C., and Le, Thuy My

Published
2019

21. Predicting food allergy: The value of patient history reinforced.

Author

Lyons, Sarah A., Knulst, André C., Burney, Peter G. J., Fernandez‐Rivas, Montserrat, Ballmer‐Weber, Barbara K., Barreales, Laura, Bieli, Christian, Clausen, Michael, Dubakiene, Ruta, Fernandez‐Perez, Cristina, Jedrzejczak‐Czechowicz, Monika, Kowalski, Marek L., Kummeling, Ischa, Kralimarkova, Tanya, Mustakov, Tihomir B., Os‐Medendorp, Harmieke, Papadopoulos, Nikolaos G., Popov, Todor A., Potts, James, and Versteeg, Serge A.

Subjects
FOOD allergy, ADULTS, FERTILIZERS, DEMOGRAPHIC surveys, GASTROINTESTINAL hemorrhage
Abstract

Background: EAACI guidelines emphasize the importance of patient history in diagnosing food allergy (FA) and the need for studies investigating its value using standardized allergy‐focused questionnaires. Objective: To determine the contribution of reaction characteristics, allergic comorbidities and demographics to prediction of FA in individuals experiencing food‐related adverse reactions. Methods: Adult and school‐age participants in the standardized EuroPrevall population surveys, with self‐reported FA, were included. Penalized multivariable regression was used to assess the association of patient history determinants with "probable" FA, defined as a food‐specific case history supported by relevant IgE sensitization. Results: In adults (N = 844), reproducibility of reaction (OR 1.35 [95% CI 1.29‐1.41]), oral allergy symptoms (OAS) (4.46 [4.19‐4.75]), allergic rhinitis (AR) comorbidity (2.82 [2.68‐2.95]), asthma comorbidity (1.38 [1.30‐1.46]) and male sex (1.50 [1.41‐1.59]) were positively associated with probable FA. Gastrointestinal symptoms (0.88 [0.85‐0.91]) made probable FA less likely. The AUC of a model combining all selected predictors was 0.85 after cross‐validation. In children (N = 670), OAS (2.26 [2.09‐2.44]) and AR comorbidity (1.47 [CI 1.39‐1.55]) contributed most to prediction of probable FA, with a combined cross‐validation‐based AUC of 0.73. When focusing on plant foods, the dominant source of FA in adults, the pediatric model also included gastrointestinal symptoms (inverse association), and the AUC increased to 0.81. Conclusions: In both adults and school‐age children from the general population, reporting of OAS and of AR comorbidity appear to be the strongest predictors of probable FA. Patient history particularly allows for good discrimination between presence and absence of probable plant FA. [ABSTRACT FROM AUTHOR]

Published
2021
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25. Secondary prevention measures in anaphylaxis patients: Data from the anaphylaxis registry.

Author

Kraft M, Knop MP, Renaudin JM, Scherer Hofmeier K, Pföhler C, Bilò MB, Lang R, Treudler R, Wagner N, Spindler T, Hourihane JO, Maris I, Koehli A, Bauer A, Lange L, Müller S, Papadopoulos NG, Wedi B, Moeser A, Ensina LF, Fernandez-Rivas M, Cichocka-Jarosz E, Christoff G, Garcia BE, Poziomkowska-Gęsicka I, Cardona V, Mustakov TB, Rabe U, Mahler V, Grabenhenrich L, Dölle-Bierke S, and Worm M

Subjects
Brazil, Epinephrine, Europe epidemiology, Humans, Registries, Anaphylaxis epidemiology, Anaphylaxis etiology, Anaphylaxis prevention & control, Secondary Prevention
Abstract

Background: Patients with a history of anaphylaxis are at risk of future anaphylactic reactions. Thus, secondary prevention measures are recommended for these patients to prevent or attenuate the next reaction., Methods: Data from the Anaphylaxis Registry were analyzed to identify secondary prevention measures offered to patients who experienced anaphylaxis. Our analysis included 7788 cases from 10 European countries and Brazil., Results: The secondary prevention measures offered varied across the elicitors. A remarkable discrepancy was observed between prevention measures offered in specialized allergy centers (84% of patients were prescribed adrenaline autoinjectors following EAACI guidelines) and outside the centers: Here, EAACI guideline adherence was only 37%. In the multivariate analysis, the elicitor of the reaction, age of the patient, mastocytosis as comorbidity, severity of the reaction, and reimbursement/availability of the autoinjector influence physician's decision to prescribe one., Conclusions: Based on the low implementation of guidelines concerning secondary prevention measures outside of specialized allergy centers, our findings highlight the importance of these specialized centers and the requirement of better education for primary healthcare and emergency physicians., (© 2019 The Authors. Allergy published by John Wiley & Sons Ltd.)

Published
2020
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