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Your search keyword '"Mustafin, Zakhar"' showing total 14 results
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14 results on '"Mustafin, Zakhar"'

2. Candidate SNP Markers Significantly Altering the Affinity of TATA-Binding Protein for the Promoters of Human Hub Genes for Atherogenesis, Atherosclerosis and Atheroprotection

Author

Bogomolov, Anton, primary, Filonov, Sergey, additional, Chadaeva, Irina, additional, Rasskazov, Dmitry, additional, Khandaev, Bato, additional, Zolotareva, Karina, additional, Kazachek, Anna, additional, Oshchepkov, Dmitry, additional, Ivanisenko, Vladimir A., additional, Demenkov, Pavel, additional, Podkolodnyy, Nikolay, additional, Kondratyuk, Ekaterina, additional, Ponomarenko, Petr, additional, Podkolodnaya, Olga, additional, Mustafin, Zakhar, additional, Savinkova, Ludmila, additional, Kolchanov, Nikolay, additional, Tverdokhleb, Natalya, additional, and Ponomarenko, Mikhail, additional

Published
2023
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4. Differentially Expressed Genes and Molecular Susceptibility to Human Age-Related Diseases

Author

Shikhevich, Svetlana, primary, Chadaeva, Irina, additional, Khandaev, Bato, additional, Kozhemyakina, Rimma, additional, Zolotareva, Karina, additional, Kazachek, Anna, additional, Oshchepkov, Dmitry, additional, Bogomolov, Anton, additional, Klimova, Natalya V., additional, Ivanisenko, Vladimir A., additional, Demenkov, Pavel, additional, Mustafin, Zakhar, additional, Markel, Arcady, additional, Savinkova, Ludmila, additional, Kolchanov, Nikolay A., additional, Kozlov, Vladimir, additional, and Ponomarenko, Mikhail, additional

Published
2023
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5. Antitumor efficacy of multi-target in situ vaccinations with CpG oligodeoxynucleotides, anti-OX40, anti-PD1 antibodies, and aptamers.

Author

Proskurina, Anastasia S., Ruzanova, Vera S., Ritter, Genrikh S., Efremov, Yaroslav R., Mustafin, Zakhar S., Lashin, Sergey A., Burakova, Ekaterina A., Fokina, Alesya A., Zatsepin, Timofei S., Stetsenko, Dmitry A., Leplina, Olga Y., Ostanin, Alexandr A., Chernykh, Elena R., and Bogachev, Sergey S.

Subjects
CPG nucleotides, APTAMERS, B cell lymphoma, IMMUNOCOMPETENT cells, IMMUNOGLOBULINS
Abstract

To overcome immune tolerance to cancer, the immune system needs to be exposed to a multi-target action intervention. Here, we investigated the activating effect of CpG oligodeoxynucleotides (ODNs), mesyl phosphoramidate CpG ODNs, anti-OX40 antibodies, and OX40 RNA aptamers on major populations of immunocompetent cells ex vivo. Comparative analysis of the antitumor effects of in situ vaccination with CpG ODNs and anti-OX40 antibodies, as well as several other combinations, such as mesyl phosphoramidate CpG ODNs and OX40 RNA aptamers, was conducted. Antibodies against programmed death 1 (PD1) checkpoint inhibitors or their corresponding PD1 DNA aptamers were also added to vaccination regimens for analytical purposes. Four scenarios were considered: a weakly immunogenic Krebs-2 carcinoma grafted in CBA mice; a moderately immunogenic Lewis carcinoma grafted in C57Black/6 mice; and an immunogenic A20 B cell lymphoma or an Ehrlich carcinoma grafted in BALB/c mice. Adding anti-PD1 antibodies (CpG+αOX40+αPD1) to in situ vaccinations boosts the antitumor effect. When to be used instead of antibodies, aptamers also possess antitumor activity, although this effect was less pronounced. The strongest effect across all the tumors was observed in highly immunogenic A20 B cell lymphoma and Ehrlich carcinoma. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Antitumor efficacy of multi-target in situ vaccinations with CpG oligodeoxynucleotides, anti-OX40, anti-PD1 antibodies, and aptamers

Author

Proskurina, Anastasia S., primary, Ruzanova, Vera S., additional, Ritter, Genrikh S., additional, Efremov, Yaroslav R., additional, Mustafin, Zakhar S., additional, Lashin, Sergey A., additional, Burakova, Ekaterina A., additional, Fokina, Alesya A., additional, Zatsepin, Timofei S., additional, Stetsenko, Dmitry A., additional, Leplina, Olga Y., additional, Ostanin, Alexandr A., additional, Chernykh, Elena R., additional, and Bogachev, Sergey S., additional

Published
2022
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8. Experimental Comparison of the In Vivo Efficacy of Two Novel Anticancer Therapies

Author

RUZANOVA, VERA S., primary, PROSKURINA, ANASTASIA S., additional, RITTER, GENRIKH S., additional, EFREMOV, YAROSLAV R., additional, NIKOLIN, VALERIY P., additional, POPOVA, NELLY A., additional, NAPRIMEROV, VASILIY A., additional, DOLGOVA, EVGENIA V., additional, POTTER, EKATERINA A., additional, KIRIKOVICH, SVETLANA S., additional, LEVITES, EVGENIY V., additional, MUSTAFIN, ZAKHAR S., additional, LASHIN, SERGEY A., additional, BURAKOVA, EKATERINA A., additional, STETSENKO, DMITRY A., additional, OSTANIN, ALEXANDR A., additional, CHERNYKH, ELENA R., additional, and BOGACHEV, SERGEY S., additional

Published
2021
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11. Phylostratigraphic Analysis Shows the Earliest Origination of the Stress Associated Genes in A. thaliana

Author

Mustafin, Zakhar, Konstantinov, Dmitry, Zamyatin, Vladimir, Doroshkov, Alexey, Lashin, Sergey, and Afonnikov, Dmitry

Subjects
plant_sciences
Abstract

Phylostratigraphic analysis is a way to look anew on phylogenetic data in the evolutionary aspect. It allows counting the evolutionary age based on the analysis of genes, their orthologs and finding the last common ancestor. We performed phylostratigraphic analysis of Arabidopsis thaliana genes associated with several types of abiotic stresses (heat, cold, water-related, light, osmotic, salt, and oxidative) determined by the Gene Ontology annotation. Comparison of the distributions of ages of genes associated with stresses of different type has shown the heat stress to involve older genes while the light stress – younger genes. At the same time, all types of stress are characterized by a significantly higher proportion of old genes (common to all eukaryotes) compared to the whole set of A.thaliana genes. This can be explained by the involvement of basic molecular processes in plant cells into the stress response. Reconstruction and graphical analysis of the gene network of the heat stress educed several clusters associated with different response functions. Some of these clusters contain only ancient genes. The results obtained show that the phylostratigraphic analysis reveals the fundamental features of the organization of gene networks and their evolution.

Published
2018

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