Background/Aim: Continuous positive airway pressure (CPAP) is the most effective treatment for obstructive sleep apnea (OSA), but adequate patient compliance is required for treatment to achieve clinical success. This study aimed to determine factors affecting compliance with CPAP therapy in patients with OSA. Methods: In this retrospective cohort study, the records of patients that started CPAP treatment due to OSA between January 1, 2018 and August 30, 2020 were reviewed. The patients were divided into two groups based on their CPAP compliance: Group 1 included those who used CPAP regularly, and Group 2 included irregular users. Parameters such as age, gender, body mass index, apnea-hypopnea index, and educational status were compared between the groups. Results: Baseline apnea-hypopnea index (AHI) and oxygen desaturation index (ODI) of patients using CPAP regularly were higher than irregular users (P=0.003, P=0.045, respectively). There was no significant difference between the groups in terms of age, gender, and body mass index (P=0.542, P=0.120 and P=0.796, respectively). In multivariate logistic regression analysis, low AHI, low ODI and low educational level were independent risk factors affecting CPAP compliance (P=0.010, P=0.016 and P=0.047, respectively). Conclusion: According to the results of this study, low AHI and ODI levels and low education status were risk factors for non-compliance with CPAP treatment. Therefore, patients with these features may require closer follow-up for early identification of CPAP treatment failure due to non-compliance.