Search

Your search keyword '"Musolino N"' showing total 129 results
Start Over Author "Musolino N"
129 results on '"Musolino N"'

1. A Brazilian multicentre study evaluating pregnancies induced by cabergoline in patients harboring prolactinomas

Author

Sant’ Anna, B. G., Musolino, N. R. C., Gadelha, M. R., Marques, C., Castro, M., Elias, P. C. L., Vilar, L., Lyra, R., Martins, M. R. A., Quidute, A. R. P., Abucham, J., Nazato, D., Garmes, H. M., Fontana, M. L. C., Boguszewski, C. L., Bueno, C. B., Czepielewski, M. A., Portes, E. S., Nunes-Nogueira, V. S., Ribeiro-Oliveira, Jr., A., Francisco, R. P. V., Bronstein, M. D., and Glezer, A.

Published
2020
Full Text
View/download PDF

3. Thermodynamic origin of the peak effect in the superconductor Nb3Sn

Author

Lortz, R., Musolino, N., Wang, Y., Junod, A., and Toyota, N.

Subjects
Condensed Matter - Superconductivity
Abstract

We report a pronounced peak effect in the magnetization and the magnetocaloric coefficient in a single crystal of the superconductor Nb3Sn. As the origin of the magnetization peak effect in classical type-II superconductors is still strongly debated, we performed an investigation of its underlying thermodynamics. Calorimetric experiments performed during field sweeps at constant temperatures reveal that the sharp increase in the current density occurs concurrently with additional degrees of freedom in the specific heat due to thermal fluctuations and a liquid vortex phase. No latent heat due to a direct first-order melting of a Bragg glass phase into the liquid phase is found which we take as evidence for an intermediate glass phase with enhanced flux pinning. The Bragg glass phase can however be restored by a small AC field. In this case a first-order vortex melting transition with a clear hysteresis is found. In the absence of an AC field the intermediate glass phase is located within the field range of this hysteresis. This indicates that the peak effect is associated with the metastability of an underlying first-order vortex melting transition.

Published
2006
Full Text
View/download PDF

4. Thermal fluctuations and vortex melting in the classical superconductor Nb3Sn from high-resolution specific-heat measurements

Author

Lortz, R., Lin, F., Musolino, N., Wang, Y., Junod, A., Rosenstein, B., and Toyota, N.

Subjects
Condensed Matter - Superconductivity
Abstract

The range of critical thermal fluctuations in classical bulk superconductors is extremely small and especially in low fields hardly experimentally inaccessible. With a new type of calorimeter we have been able to resolve a small lambda anomaly within a narrow temperature range around the Hc2 line. We show that the evolution of the anomaly as a function of magnetic field follows scaling laws expected in the presence of critical fluctuations. The lower onset of the fluctuation regime shows many characteristics of a continuous solid-to-liquid transition in the vortex matter. It can be driven into a first-order vortex melting transition by a small AC field which helps the vortex matter to reach equilibrium., Comment: 12 pages, 5 figures new extended version, more figures added, more detailed discussion about the vortex melting transition

Published
2006
Full Text
View/download PDF

5. High-pressure synthesis of pure and doped superconducting MgB2 compounds

Author

Toulemonde, P., Musolino, N., and Flukiger, R.

Subjects
Condensed Matter - Superconductivity
Abstract

Superconducting properties of bulk, dense, pure MgB2 and doped (Mg1-xAx)B2 samples with A = Na, Ca, Cu, Ag, Zn and Al were studied for compositional ranges 0 < x < 0.20. The effect on pinning properties and critical current were investigated, particularly for A = aluminium. The samples were sintered and/or synthesised at high pressure - high temperature in a cubic multi-anvils press (typically : 3.5-6 GPa, 900-1000C). They were characterised by x-ray diffraction, scanning electron microscopy and their superconducting properties were investigated by a.c. susceptibility, magnetisation (VSM and SQUID) and transport measurements under magnetic field. Only Al substitutes really on the Mg site. The other elements form secondary phases with B or Mg which do not act as pinning centres. No positive effect is observed on the superconducting properties of the bulk MgB2 samples added with these doping elements : Tc, jc critical current, Hirr and Hc2. For Al, the effect on Hc2 remains small, and the irreversibility line does not move, thus not improving the critical current of the Al-doped MgB2 samples., Comment: 32 pages, 12 figures, submitted to Superond. Sci. Technol. (Proceedings BOROMAG, Genova, Italy, June 17-19, 2002

Published
2002
Full Text
View/download PDF

6. Superconductivity in high-pressure synthesized pure and doped MgB2 compounds

Author

Toulemonde, P., Musolino, N., Suo, H. L., and Flukiger, R.

Subjects
Condensed Matter - Superconductivity
Abstract

Dense pure and doped (Mg1-xAx)B2 samples with A = Na, Ca, Cu, Ag, Zn and Al were synthesized at high pressure - high temperature in a multi anvils press (3.5-6 GPa, 900-1000C) for x up to 0.20. They were studied by x-ray diffraction, scanning electron microscopy and their superconducting properties were investigated by a.c. susceptibility, magnetization and transport measurements. Only Al is really substituted on the Mg site. The others elements form secondary phases with B or Mg. No large effect is observed on the superconducting properties Tc, jc critical current, Hirr and Hc2., Comment: 21 pages, 7 figures, submitted to Journal of Superconductivity (Proceedings SCRM 2002)

Published
2002

7. Transport critical current, anisotropy, irreversibility fields and exponential n factors in Fe sheathed MgB2 tapes

Author

Beneduce, C., Suo, H. L., Toulemonde, P., Musolino, N., and Flukiger, R.

Subjects
Condensed Matter - Superconductivity
Abstract

The influence of the initial MgB2 grain size on critical current density, upper critical fields and irreversibility has been studied on Fe sheathed monofilamentary MgB2 tapes prepared by the Powder-In-Tube technique. The effect of the reduction of MgB2 grain size by ball milling was mainly to enhance both the critical current density, jc, and the irreversibility field, while the upper critical field remained unchanged. The anisotropy ratio of the upper critical field between magnetic fields parallel and perpendicular the tape surface was determined to 1.3, reflecting a deformation induced texture. A good agreement has been found between resistive and inductive jc values, measured at various temperatures. At 25K and 1 T, jc values close to 105 A/cm2 were measured. The exponential n factor of the resistive transition was found to be quite high at low fields, and decrease linearly from 60 at 4T to 10 at 8.5T., Comment: 23 pages, 9 figures

Published
2002

11. Priorities for the global advancement of care for older adults with cancer: an update of the International Society of Geriatric Oncology Priorities Initiative

Author

Extermann, M., Brain, E., Canin, B., Cherian, M.N., Cheung, K.L., Glas, N. de, Devi, B., Hamaker, M., Kanesvaran, R., Karnakis, T., Kenis, C., Musolino, N., O'Donovan, A., Soto-Perez-de-Celis, E., Steer, C., Wildiers, H., and Int Soc Geriatric Oncology

Abstract

In 2011, the International Society of Geriatric Oncology (SIOG) published the SIOG 10 Priorities Initiative, which defined top priorities for the improvement of the care of older adults with cancer worldwide.' Substantial scientific, clinical, and educational progress has been made in line with these priorities and international health policy developments have occurred, such as the shift of emphasis by WHO from communicable to non-communicable diseases and the adoption by the UN of its Sustainable Development Goals 2030. Therefore, SIOG has updated its priority list. The present document addresses four priority domains: education, clinical practice, research, and strengthening collaborations and partnerships. In this Policy Review, we reflect on how these priorities would apply in different economic settings, namely in high-income countries versus low-income and middle-income countries. SIOG hopes that it will offer guidance for international and national endeavours to provide adequate universal health coverage for older adults with cancer, who represent a major and rapidly growing group in global epidemiology.

Published
2021

13. Significant benefits of AIP testing and clinical screening in familial isolated and young-onset pituitary tumors

Author

Marques, P, Caimari, F, Hernández-Ramírez, LC, Collier, D, Iacovazzo, D, Ronaldson, A, Magid, K, Lim, CT, Stals, K, Ellard, S, Grossman, AB, Korbonits, M, Abraham, P, Aflorei, E, Agha, A, Ahlquist, J, Akker, SA, Alexandraki, K, Alföldi, S, Anselmo, J, Arlt, W, Atkinson, B, Aulinas-Masó, A, Aylwin, SJ, Baborie, A, Backeljauw, PF, Badiu, C, Baldeweg, S, Ball, S, Bano, G, Barkan, A, Barton, J, Barwell, J, Bates, P, Bernal-González, C, Besser, M, Bevan, JS, Bickerton, A, Blair, J, Bolanowski, M, Bouloux, P, Bradley, L, Bradley, K, Brain, C, Brooke, A, Brown, R, Buchfelder, M, Burren, C, Cakir, M, Canham, N, Capraro, J, Carroll, P, Carter, P, Carty, D, Cavlan, D, Chahal, HS, Cheetham, T, Chentli, F, Choong, C, Christ-Crain, M, Chung, T-T, Clayton, P, Clayton, RN, Cohen, M, Courtney, H, Cove, D, Crowne, E, Cuthbertson, D, Dal, J, Dalantaeva, N, Damjanovic, S, Daousi, C, Darzy, K, Dattani, M, Davies, M, Davies, J, Davis, J, de Castro, M, de Marinis, L, Deal, C, Dénes, J, Dimitri, P, Dorward, N, Dow, G, Drake, W, Druce, M, Drummond, J, Dutta, P, Dzeranova, L, Edén-Engström, B, Eeles, R, Elfving, M, Ellis, K, Elston, M, Emmerson, L, Ezzat, S, Fersht, N, Fica, S, Fischli, S, Fleseriu, M, Forsythe, E, Foulkes, W, Freda, P, Friedman, T, Gadelha, M, Gainsborough, M, Gallacher, S, Gallego, P, Gan, H-W, Georgescu, C, Gevers, E, Gilkes, C, Glynn, N, Goldman, JE, Goldstone, AP, Góth, M, Green, A, Greenhalgh, L, Grieve, J, Griz, L, Guitelman, M, Gürlek, A, Gurnell, M, Hamblin, PS, Hana, V, Harding, P, Hay, E, Hilton, DA, Ho, W, Hong, G, Horváth, K, Howell, S, Howlett, TA, Höybye, C, Hunter, S, Idampitiya, C, Igaz, P, Imran, A, Inder, WJ, Iwata, T, Izatt, L, Jagadeesh, S, Johnston, C, Jose, B, Kaltsas, G, Kaplan, F, Karavitaki, N, Kastelan, D, Katz, M, Kearney, T, Kershaw, M, Khoo, B, Kiraly-Borri, C, Knispelis, R, Kovács, GL, Kumar, A, Kumar, AV, Kun, IZ, Kyriaku, A, Lambrescu, I, Lampe, AK, Laws, ER, Lebek-Szatanska, A, Lechan, RM, Leese, G, Levy, A, Levy, MJ, Lewandowski, K, Lin, E, Lo, J, Lyons, C, Maartens, N, Maghnie, M, Makaya, T, Marcus, H, Niedziela, M, Martin, N, Matsuno, A, McGowan, B, McQuaid, SE, Medic-Stojanoska, M, Mendoza, N, Mercado-Atri, M, Mettananda, S, Mezősi, E, Miljic, D, Miller, KK, Modenesi, S, Molitch, ME, Monson, J, Morris, DG, Morrison, PJ, Mosterman, B, Munir, A, Murray, RD, Musat, M, Musolino, N, Nachtigall, L, Nagi, D, Nair, R, Nelson, R, Newell-Price, J, Nikookam, K, Ogilivie, A, Orme, SM, O´Weickert, M, Pal, A, Pascanu, I, Patócs, A, Patterson, C, Pearce, SH, Giraldi, FP, Penney, L, Perez-Rivas, LG, Pfeifer, M, Pirie, F, Poplawski, N, Popovic, V, Powell, M, Pullan, P, Quinton, R, Radian, S, Randeva, H, Reddy, N, Rees, A, Renals, V, de Oliveira, AR, Richardson, T, Rodd, C, Ross, RJM, Roncaroli, F, Ryan, F, Salvatori, R, Schöfl, C, Shears, D, Shotliff, K, Skelly, R, Snape, K, Soares, BS, Somasundaram, N, Spada, A, Sperber, J, Spoudeas, H, Stelmachowska-Banas, M, Stewart, S, Storr, HL, Strasburger, C, Street, ME, Suter-Widmer, I, Suthers, G, Swords, F, Syro, LV, Swantje, B, Sze, C, Taylor, J, Thakker, RV, Tham, E, Thompson, C, Thorner, MO, Tóth, M, Trainer, PJ, Tsagarakis, S, Twine, G, Tzanela, M, Vadasz, J, Vaidya, B, Vaks, V, Vance, ML, Verkauskiene, R, Von Esch, H, Wass, JA, Waterhouse, M, Webb, S, Weber, A, Wernig, F, Widell, H, Yamada, S, Yap, P, Yarman, S, Yeoh, P, Yoshimoto, K, Yuen, K, and Zammitt, NN

Abstract

Context\ud \ud Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are responsible for a subset of familial isolated pituitary adenoma (FIPA) cases and sporadic pituitary neuroendocrine tumors (PitNETs).\ud \ud \ud \ud Objective\ud \ud To compare prospectively diagnosed AIP mutation-positive (AIPmut) PitNET patients with clinically presenting patients and to compare the clinical characteristics of AIPmut and AIPneg PitNET patients.\ud \ud \ud \ud Design\ud \ud 12-year prospective, observational study.\ud \ud \ud \ud Participants & Setting\ud \ud We studied probands and family members of FIPA kindreds and sporadic patients with disease onset ≤18 years or macroadenomas with onset ≤30 years (n = 1477). This was a collaborative study conducted at referral centers for pituitary diseases.\ud \ud \ud \ud Interventions & Outcome\ud \ud AIP testing and clinical screening for pituitary disease. Comparison of characteristics of prospectively diagnosed (n = 22) vs clinically presenting AIPmut PitNET patients (n = 145), and AIPmut (n = 167) vs AIPneg PitNET patients (n = 1310).\ud \ud \ud \ud Results\ud \ud Prospectively diagnosed AIPmut PitNET patients had smaller lesions with less suprasellar extension or cavernous sinus invasion and required fewer treatments with fewer operations and no radiotherapy compared with clinically presenting cases; there were fewer cases with active disease and hypopituitarism at last follow-up. When comparing AIPmut and AIPneg cases, AIPmut patients were more often males, younger, more often had GH excess, pituitary apoplexy, suprasellar extension, and more patients required multimodal therapy, including radiotherapy. AIPmut patients (n = 136) with GH excess were taller than AIPneg counterparts (n = 650).\ud \ud \ud \ud Conclusions\ud \ud Prospectively diagnosed AIPmut patients show better outcomes than clinically presenting cases, demonstrating the benefits of genetic and clinical screening. AIP-related pituitary disease has a wide spectrum ranging from aggressively growing lesions to stable or indolent disease course.

Published
2020

15. Properties of YBCO films at high current densities: Fault current limiter implications

Author

Decroux, M., Antognazza, L., Musolino, N., de Chambrier, E., Reymond, S., Triscone, J.M., Fischer, O., Paul, W., and Chen, M.

Subjects
Limiter circuits -- Research, Superconductors -- Research, Business, Electronics, Electronics and electrical industries
Abstract

Superconducting strip lines based on epitaxial YBCO thin films were studied for their superconducting properties.

Published
2001

23. A Brazilian multicentre study evaluating pregnancies induced by cabergoline in patients harboring prolactinomas

Author

Sant’ Anna, B. G., primary, Musolino, N. R. C., additional, Gadelha, M. R., additional, Marques, C., additional, Castro, M., additional, Elias, P. C. L., additional, Vilar, L., additional, Lyra, R., additional, Martins, M. R. A., additional, Quidute, A. R. P., additional, Abucham, J., additional, Nazato, D., additional, Garmes, H. M., additional, Fontana, M. L. C., additional, Boguszewski, C. L., additional, Bueno, C. B., additional, Czepielewski, M. A., additional, Portes, E. S., additional, Nunes-Nogueira, V. S., additional, Ribeiro-Oliveira, A., additional, Francisco, R. P. V., additional, Bronstein, M. D., additional, and Glezer, A., additional

Published
2019
Full Text
View/download PDF

26. A Brazilian multicentre study evaluating pregnancies induced by cabergoline in patients harboring prolactinomas.

Author

Sant' Anna, B. G., Musolino, N. R. C., Gadelha, M. R., Marques, C., Castro, M., Elias, P. C. L., Vilar, L., Lyra, R., Martins, M. R. A., Quidute, A. R. P., Abucham, J., Nazato, D., Garmes, H. M., Fontana, M. L. C., Boguszewski, C. L., Bueno, C. B., Czepielewski, M. A., Portes, E. S., Nunes-Nogueira, V. S., and Ribeiro-Oliveira, A.

Abstract

Objective: To evaluate the maternal–fetal outcomes of CAB-induced pregnancies in patients with prolactinoma in a large cohort. Methods: The prevalence of tumor growth, miscarriage, preterm, low birth weight, congenital malformations and impairment in neuropsychological development in children among women treated with CAB were assessed in a Brazilian multicentre retrospective observational study, Results: We included 194 women with a mean age of 31 (17–45) years, 43.6% presenting microadenomas and 56.4% macroadenomas, at prolactinoma diagnosis. In 233 pregnancies, CAB was withdrawn in 89%, after pregnancy confirmation. Symptoms related to tumor growth occurred in 25 cases, more frequently in macroadenomas. The overall miscarriage rate was 11%, although higher in the subgroup of patients with CAB maintainance after pregnancy confirmation (38% vs. 7.5%). Amongst the live-birth deliveries, preterm occurred in 12%, low birth weight in 6% and congenital malformations in 4.3%. Neuropsychological development impairment was reported in 7% of cases. Conclusions: Our findings confirm previous results of safety in maternal and fetal outcomes in CAB-induced pregnancies; nevertheless, CAB maintenance after pregnancy confirmation was associated with higher miscarriage rate; result that must be further confirmed. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

27. Landscape of familial isolated and young-onset pituitary adenomas: Prospective diagnosis in AIP mutation carriers

Author

Hernandez-Ramirez, L.C., Gabrovska, P., Denes, J., Stals, K., Trivellin, G., Tilley, D., Ferrau, F., Evanson, J., Ellard, S., Grossman, A.B., Roncaroli, F., Gadelha, M.R., Korbonits, M., Agha, A., Akker, S.A., Aflorei, E.D., Alföldi, S., Arlt, W., Atkinson, B., Aulinas-Masó, A., Aylwin, S.J., Backeljauw, P.F., Badiu, C., Baldeweg, S., Bano, G., Barkan, A., Barwell, J., Bernal-González, C., Besser, G., Bevan, J.S., Blair, J., Bouloux, P., Bradley, L., Buchfelder, M., Cakir, M., Canham N, ., Carroll, P., Chahal, H.S., Cheetham, T., Chentli, F., Clayton, R.N., Cohen, M., Cole, T., Courtney, H., Crowne, E., Cuthbertson, D., Dal J, ., Dalantaeva, N., Daousi, C., Darzy, K., Dattani, M., Davies, J.H., Davis, J., De Castro, M., De Marinis, L., Drake, W., Dutta, P., Dzeranova, L., Edén-Engström, B., Eeles, R., Elfving, M., Elston, M., Emmerson, L., Fersht, N., Fica, S., Fischli, S., Flanagan, D., Fleseriu, M., Freda, P.U., Friedman, T., Frohman, L.A., Gallego, P., Gevers, E., Gláz, E., Goldman, J.A., Goldstone, A.P., Goth, M., Greenhalgh, L., Grieve, J., Guitelman, M., Gürlek, A., Gurnell, M., Horvath, K., Howlett, T.A., Höybye, C., Hunter S, ., Iacovazzo D, ., Igaz, P., Inder, W.J., Iwata, T., Izatt, L., Jagadeesh, S., Kaltsas, G., Kaplan F, ., Karavitaki, N., Kastelan, D., Katz, M., Kearney, T., Khoo, B., Kiraly-Borri, C., Knispelis, R., Kovács, G.L., Kumar, A.V., Laws, E.R., Lechan, R.M., Levy, J., Lewandowski, K., Lo, J., Maartens, N., Matsuno, A., Mcgowan, B., Mcquaid, S.E., Medic-Stojanoska, M., Mercado-Atri, M., Mezősi, E., Miljic, D., Miller, K.K., Modenesi, S., Molitch, M.E., Monson, J., Morris, D.G., Morrison, P.J., Munir, A., Murray, R.D., Musat, M., Musolino, N., Nachtigall, L., Newell-Price, J., Ogilvie, A., Orme, S.M., Paşcanu, I., Patócs, A., Patterson, C., Pearce, S.H., Pecori Giraldi, F., Pfeifer, M., Popovic, V., Poplawski, N., Powell, M., Pullan, P., Quinton, R., Radian, S., Randeva, H., Ribeiro-Oliveira, A., Rodd, C., Ryan, F., Salvatori, R., Schöfl, C., Shears, D., Shotliff, K., Soares, B.S., Spada, A., Sperber, J., Spoudeas, H.A., Stewart, S., Storr, H., Strasburger, C., Street, M.E., Swords, F., Thakker, R.V., Tham, E., Thompson, C., Thorner, M.O., Tóth, M., Trainer, P.J., Tsagarakis, S., Tzanela, M., Vadász, J., Vaks, V., Verkauskiene, R., Wass, J.A., Webb, S.M., Weber, A., Yamada, S., Yarman, S., Yeoh, P., Yoshimoto, K., Zammitt, N.N., and İç hastalıkları

Subjects
Adenoma, Adult, Male, Adolescent, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Genetic Testing, Germ-Line Mutation, Growth Hormone-Secreting Pituitary Adenoma, Humans, Intracellular Signaling Peptides and Proteins, Longitudinal Studies, Middle Aged, Mutation, Pituitary Neoplasms, Prospective Studies, Young Adult, Endocrinology, Diabetes and Metabolism, Biochemistry, Endocrinology, Clinical Biochemistry, Biochemistry (medical), Observational Study, Settore MED/13 - Endocrinologia, Journal Article, 80 and over, Preschool, JCEM Online: Advances in Genetics, Research Support, Non-U.S. Gov't
Abstract

Context:Familial isolated pituitary adenoma (FIPA) due to aryl hydrocarbon receptor interacting protein (AIP) gene mutations is an autosomal dominant disease with incomplete penetrance. Clinical screening of apparently unaffected AIP mutation (AIPmut) carriers could identify previously unrecognized disease.Objective:To determine the AIP mutational status of FIPA and young pituitary adenoma patients, analyzing their clinical characteristics, and to perform clinical screening of apparently unaffected AIPmut carrier family members.Design:This was an observational, longitudinal study conducted over 7 years.Setting:International collaborative study conducted at referral centers for pituitary diseases.Participants:FIPA families (n = 216) and sporadic young-onset (≤30 y) pituitary adenoma patients (n = 404) participated in the study.Interventions:We performed genetic screening of patients for AIPmuts, clinical assessment of their family members, and genetic screening for somatic GNAS1 mutations and the germline FGFR4 p.G388R variant.Main Outcome Measure(s):We assessed clinical disease in mutation carriers, comparison of characteristics of AIPmut positive and negative patients, results of GNAS1, and FGFR4 analysis.Results:Thirty-seven FIPA families and 34 sporadic patients had AIPmuts. Patients with truncating AIPmuts had a younger age at disease onset and diagnosis, compared with patients with nontruncating AIPmuts. Somatic GNAS1 mutations were absent in tumors from AIPmut-positive patients, and the studied FGFR4 variant did not modify the disease behavior or penetrance in AIPmut-positive individuals. A total of 164 AIPmut-positive unaffected family members were identified; pituitary disease was detected in 18 of those who underwent clinical screening.Conclusions:A quarter of the AIPmut carriers screened were diagnosed with pituitary disease, justifying this screening and suggesting a variable clinical course for AIPmut-positive pituitary adenomas.

Published
2015
Full Text
View/download PDF

30. Origin of the magnetization peak effect in the Nb3Sn superconductor

Author

Lortz, Rolf W. PHYS, Musolino, N., Wang, Y., Junod, A., Toyota, N., Lortz, Rolf W. PHYS, Musolino, N., Wang, Y., Junod, A., and Toyota, N.

Abstract

We report a pronounced peak effect in the magnetization and the magnetocaloric coefficient in a single crystal of the superconductor Nb3Sn. As the origin of the magnetization peak effect in classical type-II superconductors is still strongly debated, we performed an investigation of its underlying thermodynamics. Calorimetric experiments performed during field sweeps at constant temperatures reveal that the sharp increase in the current density occurs concurrently with additional degrees of freedom in the specific heat due to thermal fluctuations and a liquid vortex phase. No latent heat due to a direct first-order melting of a Bragg glass phase into the liquid phase is found, which we take as evidence for an intermediate glass phase with enhanced flux pinning. The Bragg glass phase can, however, be restored by a small ac field. In this case, a first-order vortex melting transition with a clear hysteresis is found. In the absence of an ac field, the intermediate glass phase is located within the field range of this hysteresis. This indicates that the peak effect is associated with the metastability of an underlying first-order vortex melting transition.

Published
2007

45. High transport and inductive critical currents in dense Fe- and Ni- clad MgB[sub 2] tapes using fine powder.

Author

Suo, H. L., Beneduce, C., Dhalle´, M., Musolino, N., Su, X. D., and Flu¨kiger, R.

Subjects
SUPERCONDUCTORS, ELECTRIC charge
Abstract

Highly dense monofilamentary MgB[sub 2]/Ni and MgB[sub 2]/Fe superconducting tapes with high transport critical current densities have been fabricated using a straightforward powder-intube (PIT) process. High density of the MgB[sub 2] core and a fine starting powder appear to be decisive factors for reaching high critical current densities. After annealing, we measured transport j[sub c] values up to 2.3 × 10[sup 5] A/cm² at 4.2 K in a field of 1.5 T (corresponding to an I[sub c] of 300 A) in a MgB[sub 2]/Ni tape and up to 10[sup 4] A/cm² at 4.2 K in 6.5 T in a MgB[sub 2]/Fe tape. For higher currents these monofilamentary tapes quenched due to insufficient thermal stability of filament thickness above 50µm. Thus, j[sub c] at 4.2K, 0T can only be extrapolated, yielding a value close to 1 MA/cm². The recrystallization during annealing leads to a densification and to j[sub c] values which are more than a factor of ∼10 higher than those measured in the asdeformed tapes. Ni shows a limited reaction with MgB[sub 2], leading to the formation of Mg[sub 2]Ni reaction layers between the filament and the matrix. On the other hand, Fe stays chemically inert and turns out to be an excellent candidate material for multifilamentary tapes with self-field j[sub c] values at 4.2 K in excess of 1 MA/cm². [ABSTRACT FROM AUTHOR]

Published
2002

47. Pharmacokinetic profile of lanreotide Autogel® in patients with acromegaly after four deep subcutaneous injections of 60, 90 or 120 mg every 28 days.

Author

Bronstein, M., Musolino, N., Jallad, R., Cendros, J. M., Ramis, J., Obach, R., Leselbaum, A., and Catus, F.

Subjects
*ACROMEGALY, *PITUITARY diseases, *GASTROINTESTINAL hormones, *SOMATOSTATIN, *PHARMACOKINETICS, *ENDOCRINOLOGY
Abstract

Objective To investigate the pharmacokinetic profile of a prolonged release, aqueous Autogel® formulation of the somatostatin analogue lanreotide (Lan-ATG). Design A phase II, randomized, double-blind study, during which patients received 60, 90 or 120 mg Lan-ATG for four fixed administrations at 28-day intervals. Patients A total of 18 patients with acromegaly were recruited; six patients were randomized to each treatment. Measurements Lanreotide minimum concentration (Cmin), maximum serum concentration (Cmax) and area under the concentration–time curve during a dosing interval (AUCτ) were assessed after a single dose and at steady state (ss). Serum GH and IGF-1 levels were assessed before each administration and at the end of the study. Results After a single administration, dose proportionality for Cmin,1, Cmax and AUCτ was demonstrated statistically. After repeated administrations, Lan-ATG exhibited linear pharmacokinetics over the dose range and ss values of Cmin, Cmax and AUCτ increased in a dose-dependent, linear manner. Mean Cmax,ss values were only two- to fourfold greater than Cmin,ss values, and there was good control over the entire release profile. Serum levels of GH and IGF-1 declined over the course of the study and acromegaly symptoms improved. The treatment was well tolerated. Conclusions Lan-ATG showed linear pharmacokinetic profiles over the three dose levels after both single and repeated dosing, no initial burst effect and good control over the entire release profile. Despite the absence of dose adaptation, four injections of Lan-ATG were effective in lowering serum levels of GH and IGF-1. [ABSTRACT FROM AUTHOR]

Published
2005
Full Text
View/download PDF

48. Spray Pyrolysis of YBa2Cu3O7-x Coated Conductors on (100) SrTiO3 Substrate.

Author

Suo, H. L., Schindl, M., Clayton, N., Musolino, N., and Flükiger, R.

Subjects
PYROLYSIS, CHEMICAL reactions, GAS flow, COATING processes, SUPERCONDUCTIVITY, AIR flow
Abstract

YBa2Cu3O7-x films have been deposited using spray pyrolysis on (100) SrTiO3 substrate. An extended study on the optimization of the composition, carrying gas flow, deposition temperature as well as annealing time was performed. It was found that these parameters are strongly correlated and affect the morphology, orientation and superconducting properties of the YBCO films. As grown films already exhibit Jc values of 104 A/cm², thus indicating that the correct structure is already formed during deposition. It was found that the temperature gradient in the pyrolysis zone played a fundamental role during the deposition. After modification of this heat gradient by adding a metallic susceptor, a noticeable improvement in the properties of the films was obtained. An in-plane orientation FWHM value of 0.70° was measured from the (102) pole figure. The films exhibited a Tc onset of 91 K (ΔTc = 1.5 K), while the Jc value at 77K in self-field approached 105 A/cm². Based on an assumed typical intragranular critical current density, we found a 40 × 40 μm area in our best film where the assumed critical current density is well above 106 A/cm². [ABSTRACT FROM AUTHOR]

Published
2005
Full Text
View/download PDF

49. Superconductivity in High-Pressure Synthesized Pure and Doped MgB2 Compounds.

Author

Toulemonde, P., Musolino, N., Suo, H., and Flükiger, R.

Abstract

Dense pure and doped (Mg1 − xA x)B2 samples with A = Na, Ca, Cu, Ag, Zn, and Al were synthesized at high pressure–high temperature in a multi-anvils press (3.5–6 GPa, 900–1000°C) for 0 < x ≤ 0.20. They were studied by X-ray diffraction, scanning electron microscopy and their superconducting properties were investigated by AC susceptibility, magnetization, and transport measurements. Only Al is really substituted on the Mg site. The other elements form secondary phases with B or Mg. No large effect is observed on the superconducting properties Tc, jc critical current, Hirr, and Hc2. [ABSTRACT FROM AUTHOR]

Published
2002
Full Text
View/download PDF

50. Highly Dissipative State of YBa2Cu3O7 Thin Films at Very Large Current Densities.

Author

Antognazza, L., Decroux, M., Musolino, N., Triscone, J.-M., Reinert, P., Koller, E., Reymond, S., Chen, M., Paul, W., and Fischer, Ø.

Abstract

Flux flow instabilities at high current densities have been recently reported to occur in high temperature superconductors. Such flux flow instabilities were already predicted by Larkin and Ovchinnikov. However, other mechanisms may possibly also account for this behaviour, as for instance hot spots or thermal instabilities. To investigate the mechanism at the origin of these instabilities, we have carried out detailed I- V experiments, using short current pulses, on YBCO thin films grown on sapphire substrates. When the current density exceeds 2-3 times the conventional critical current density, we observe an extremely fast transition from a low dissipative state into a highly dissipative state. We present some indications that this transition does not originate from temperature instabilities but is driven by the current. [ABSTRACT FROM AUTHOR]

Published
1999
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results