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353 results on '"Mushtaq, Sajid"'

2. A digital score of tumour-associated stroma infiltrating lymphocytes predicts survival in head and neck squamous cell carcinoma

Author

Shaban, Muhammad, Raza, Shan E Ahmed, Hassan, Mariam, Jamshed, Arif, Mushtaq, Sajid, Loya, Asif, Batis, Nikolaos, Brooks, Jill, Nankivell, Paul, Sharma, Neil, Robinson, Max, Mehanna, Hisham, Khurram, Syed Ali, and Rajpoot, Nasir

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning
Abstract

The infiltration of T-lymphocytes in the stroma and tumour is an indication of an effective immune response against the tumour, resulting in better survival. In this study, our aim is to explore the prognostic significance of tumour-associated stroma infiltrating lymphocytes (TASILs) in head and neck squamous cell carcinoma (HNSCC) through an AI based automated method. A deep learning based automated method was employed to segment tumour, stroma and lymphocytes in digitally scanned whole slide images of HNSCC tissue slides. The spatial patterns of lymphocytes and tumour-associated stroma were digitally quantified to compute the TASIL-score. Finally, prognostic significance of the TASIL-score for disease-specific and disease-free survival was investigated with the Cox proportional hazard analysis. Three different cohorts of Haematoxylin & Eosin (H&E) stained tissue slides of HNSCC cases (n=537 in total) were studied, including publicly available TCGA head and neck cancer cases. The TASIL-score carries prognostic significance (p=0.002) for disease-specific survival of HNSCC patients. The TASIL-score also shows a better separation between low- and high-risk patients as compared to the manual TIL scoring by pathologists for both disease-specific and disease-free survival. A positive correlation of TASIL-score with molecular estimates of CD8+ T cells was also found, which is in line with existing findings. To the best of our knowledge, this is the first study to automate the quantification of TASIL from routine H&E slides of head and neck cancer. Our TASIL-score based findings are aligned with the clinical knowledge with the added advantages of objectivity, reproducibility and strong prognostic value. A comprehensive evaluation on large multicentric cohorts is required before the proposed digital score can be adopted in clinical practice.

Published
2021

8. THE NEXUS BETWEEN TRANSFORMATIONAL LEADERSHIP AND JOB CRAFTING: A MEDIATION MODERATION ANALYSIS.

Author

Mukhtar, Sana, Mushtaq, Sajid, and Umair Nasir, Hafiz Muhammad

Subjects
LEADERSHIP, ACQUISITION of data, PSYCHOLOGICAL ownership, JOB performance, POLICY sciences
Abstract

The leadership, in all respects, is responsible for inspiration of employees toward desired objectives and ultimately the success of organizations. This study aims to analyze effect of transformational leadership on job crafting. This study used structured questionnaire for the data collection purpose. The questionnaire was conducted to personnel from educational sector of in Pakistan. A total of 250 surveys were distributed, with a 97% response rate. SPSS Process Macro was used for the analysis of the data. The findings indicate that psychological ownership improves the association between transformational leadership and job crafting. A healthy work environment minimizes stress and improves performance outcomes. The innovative work behavior is a vital factor that boosts individual towards performance thus leading to organizational success. This study aims to first analyze positive affect the relationship of transformational leadership and job crafting and therefore provides significant contribution to the psychological ownership, and innovative work behavior with mediation and moderation effect and job crafting as dependent variable. This study offered significant outcomes that may help policymakers in revisiting their policies towards the issues under considerations. [ABSTRACT FROM AUTHOR]

Published
2024
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9. THE LINKAGES BETWEEN KNOWLEDGE HIDING & KNOWLEDGE SHARING VIA LMX & AGREEABLENESS: A MEDIATED MODERATED MODEL.

Author

Mushtaq, Sajid, Mukhtar, Sana, and Umair Nasir, Hafiz Muhammad

Subjects
THEORY of knowledge, AGREEABLENESS, SOCIOLOGY of work, ATTITUDES toward work, KINDNESS
Abstract

The study will contribute to the knowledge hiding literature by providing interesting insights in trickledown effect of supervisor knowledge hiding on subordinate knowledge sharing behavior with the co-workers, while; here, LMX as mediator would extend literature of knowledge hiding. Drawing on SET & COR theory by using cross-sectional data collected over structured questionnaire from employees of TEVTA organization, the research will be a considerable addition in both knowledge hiding and knowledge sharing literature. It would also provide the considerable knowledge in OB studies where personality traits i.e., agreeableness as moderator will influence upon relationship of LMX and knowledge sharing by subordinate with coworkers. It argues that, the effects of supervisor knowledge hiding (predictor) not stop at subordinate end while it transmits (trickledown) in coworker and badly affect their social well-being (outcome). More interestingly, agreeableness will moderate relation of LMX & subordinate knowledge sharing behavior with co-workers while the COR will support to author's stance. In addition, theoretical and practical implications of the study are also a key point of the present research. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Shared Leadership and Creativity in Teams: Moderating Role of Team Engagement

Author

Ramzan, Ariba, Zeb, Nayyra, Mukhtar, Sana, Mushtaq, Sajid, and Iqbal, Irfan

Subjects
Shared leadership, Team engagement, Team Autonomy, Team creativity
Abstract

Complementarity between the traits of the team's leader and members aids in encouraging shared leadership in teams and improving creativity. By employing social learning theory, this research explores the role of shared leadership in promoting creativity in teams. To test our model, we collected data from 300 members of 30 teams. Results revealed that shared leadership is positively associated with team creativity and team autonomy mediates the relationship between shared leadership and team creativity. Moreover, team engagement moderates these relationships. This paper also discusses the theoretical contributions, practical implications and potential future directions of our findings.

Published
2023
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44. A digital score of tumour‐associated stroma infiltrating lymphocytes predicts survival in head and neck squamous cell carcinoma

Author

Shaban, Muhammad, primary, Raza, Shan E Ahmed, additional, Hassan, Mariam, additional, Jamshed, Arif, additional, Mushtaq, Sajid, additional, Loya, Asif, additional, Batis, Nikolaos, additional, Brooks, Jill, additional, Nankivell, Paul, additional, Sharma, Neil, additional, Robinson, Max, additional, Mehanna, Hisham, additional, Khurram, Syed Ali, additional, and Rajpoot, Nasir, additional

Published
2021
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