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1. A Cross-Sectional Study of Variant Interpretation and Reporting of NGS Data Using Tertiary Analysis Software: Navify® Mutation Profiler

Author

Pepe, Francesco, Russo, Gianluca, Barraco, Nadia, Bono, Marco, Listì, Angela, Righi, Luisella, de Biase, Dario, Maloberti, Thais, Scimone, Claudia, Palumbo, Lucia, Rocco, Danilo, Roscigno, Giuseppina, Gallo, Enzo, Buglioni, Simonetta, Coco, Michelina, Muscarella, Lucia Anna, Troncone, Giancarlo, and Malapelle, Umberto

Published
2024
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4. Which Ion Dominates Temperature and Pressure Response of Halide Perovskites and Elpasolites?

Author

Muscarella, Loreta A., Jöbsis, Huygen J., Baumgartner, Bettina, Prins, P. Tim, Maaskant, D. Nicolette, Petukhov, Andrei V., Chernyshov, Dmitry, McMonagle, Charles J., and Hutter, Eline M.

Subjects
Condensed Matter - Materials Science
Abstract

Halide perovskite and elpasolite semiconductors are extensively studied for optoelectronic applications due to their excellent performance together with significant chemical and structural flexibility. However, there is still limited understanding of their basic elastic properties and how they vary with composition and temperature, which is relevant for synthesis and device operation. To address this, we performed temperature- and pressure-dependent synchrotron-based powder X-ray diffraction (XRD). In contrast to previous pressure-dependent XRD studies, our relatively low pressures (ambient to 0.06 GPa) enabled us to investigate the elastic properties of halide perovskites and elpasolites in their ambient crystal structure. We find that halide perovskites and elpasolites show common trends in the bulk modulus and thermal expansivity. Both materials become softer as the halide ionic radius increases from Cl to Br to I, exhibiting higher compressibility and larger thermal expansivity. The mixed-halide compositions show intermediate properties to the pure compounds. Contrary, cations show a minor effect on the elastic properties. Finally, we observe that thermal phase transitions in e.g., MAPbI3 and CsPbCl3 lead to a softening of the lattice, together with negative expansivity for certain crystal axes, already tens of degrees away from the transition temperature. Hence, the range in which the phase transition affects thermal and elastic properties is substantially broader than previously thought. These findings highlight the importance of considering the temperature-dependent elastic properties of these materials, since stress induced during manufacturing or temperature sweeps can significantly impact the stability and performance of the corresponding devices.

Published
2023

5. Conduction band tuning by controlled alloying of Fe into Cs2AgBiBr6 double perovskite powders

Author

Jobsis, Huygen J., Fykouras, Kostas, Reinders, Joost W. C., van Katwijk, Jacco, Dorresteijn, Joren M., Arens, Tjom, Vollmer, Ina, Muscarella, Loreta A., Leppert, Linn, and Hutter, Eline M.

Subjects
Condensed Matter - Materials Science, Physics - Chemical Physics
Abstract

Halide double perovskite semiconductors such as Cs2AgBiBr6 are widely investigated as a more stable, less toxic alternative to lead-halide perovskites in light conversion applications including photovoltaics and photoredox catalysis. However, the relatively large and indirect bandgap of Cs2AgBiBr6 limits efficient sunlight absorption. Here, we show that controlled replacement of Bi3+ with Fe3+ via mechanochemical synthesis results in a remarkable tunable absorption onset between 2.1 and ~1 eV. Our first-principles density functional theory (DFT) calculations suggest that this bandgap reduction originates primarily from a lowering of the conduction band upon introduction of Fe3+. Furthermore, we find that the tunability of the conduction band energy is reflected in the photoredox activity of these semiconductors. Finally, our DFT calculations predict a direct bandgap when >50% of Bi3+ is replaced with Fe3+. Our findings open new avenues for enhancing the sunlight absorption of double perovskite semiconductors and for harnessing their full potential in sustainable energy applications.

Published
2023

6. The EXTRA-BL4S experiment for the measurement of the energy and angular distributions of transition radiation X-rays

Author

Mazziotta, M. N., Loparco, F., Anelli, A., Belviso, M. M., Buquicchio, A., Cassano, E. V., De Cosmo, M., Ginefra, P., Martulli, M. L., Picci, C., Picicci, D., Soriano, R. D., Tatulli, A. P., Tripaldella, G., Zupo, V. M., Muscarella, M. F., Turbacci, S., Boselli, M., Silva, C. B. da Cruz E, Joos, M., and Schütze, P.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

We have designed and implemented an experiment to measure the angular distributions and the energy spectra of the transition radiation X-rays emitted by fast electrons and positrons crossing different radiators. Our experiment was selected among the proposals of the 2021 Beamline for Schools contest, a competition for high-school students organized every year by CERN and DESY, and was performed at the DESY II Test Beam facility area TB21, using a high-purity beam of electrons or positrons with momenta in the range from 1 to 6 GeV/c. The measurements were performed using a 100 um thick silicon pixel detector, with a pitch of 55 um. Our results are consistent with the expectations from the theoretical models describing the production of transition radiation in multilayer regular radiators., Comment: 18 pages, 11 figures; Version to match the accepted manuscript by JINST

Published
2023
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9. Ammonium adsorption, desorption and recovery by acid and alkaline treated zeolite

Author

Muscarella, Sofia Maria, Badalucco, Luigi, Cano, Beatriz, Laudicina, Vito Armando, and Mannina, Giorgio

Subjects
Physics - Applied Physics, Physics - Chemical Physics
Abstract

In this study, the suitability of zeolite as a possible medium for ammonium adsorption, desorption and recovery from wastewater was investigated. Specifically, batch adsorption and desorption studies with solutions enriched in NH$_4^+$ were conducted employing zeolite to evaluate how the chemical treatment and contact time affect adsorption and desorption. Several experimental tests were carried out considering both untreated and treated zeolite. Untreated and HCl-Na treated zeolite adsorbed up to 11.8 mg NH$_4^+$ g$^{-1}$ and showed the highest efficiency in recovering NH$_4^+$ from aqueous solution. Regardless of pre-treatment, treatments with NaCl resulted in higher and faster adsorption of NH$_4^+$ than treatments with CaCl$_2$ and MgCl$_2$., Comment: 15 pages, 2 figures

Published
2021
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10. Accelerated hot-carrier cooling in MAPbI3 perovskite by pressure-induced lattice compression

Author

Muscarella, Loreta A., Hutter, Eline M., Frost, Jarvist M., Grimaldi, Gianluca G., Versluis, Jan, Bakker, Huib J., and Ehrler, Bruno

Subjects
Condensed Matter - Materials Science, Physics - Applied Physics
Abstract

Hot-carrier cooling (HCC) in metal halide perovskites in the high-density regime is significantly slower compared to conventional semiconductors. This effect is commonly attributed to a hot-phonon bottleneck but the influence of the lattice properties on the HCC behaviour is poorly understood. Using pressure-dependent transient absorption spectroscopy (fs-TAS) we find that at an excitation density below Mott transition, pressure does not affect the HCC. On the contrary, above Mott transition, HCC in methylammonium lead iodide (MAPbI3) is around two times as fast at 0.3 GPa compared to ambient pressure. Our electron-phonon coupling calculations reveal about two times stronger electron-phonon coupling for the inorganic cage mode at 0.3 GPa. However, our experiments reveal that pressure promotes faster HCC only above Mott transition. Altogether, these findings suggest a change in the nature of excited carriers in the high-density regime, providing insights on the electronic behavior of devices operating at such high charge-carrier density.

Published
2021

11. ENM2020: A Free Online Course and Set of Resources on Modeling Species' Niches and Distributions

Author

Peterson, A Townsend, Aiello-Lammens, Matthew, Amatulli, Giuseppe, Anderson, Robert, Cobos, Marlon, Diniz-Filho, José Alexandre, Escobar, Luis, Feng, Xiao, Franklin, Janet, Gadelha, Luiz, Georges, Damien, Guéguen, M, Gueta, Tomer, Ingenloff, Kate, Jarvie, Scott, Jiménez, Laura, Karger, Dirk, Kass, Jamie, Kearney, Michael, Loyola, Rafael, Machado-Stredel, Fernando, Martínez-Meyer, Enrique, Merow, Cory, Mondelli, Maria Luiza, Mortara, Sara, Muscarella, Robert, Myers, Corinne, Naimi, Babak, Noesgaard, Daniel, Ondo, Ian, Osorio-Olvera, Luis, Owens, Hannah, Pearson, Richard, Pinilla-Buitrago, Gonzalo, Sánchez-Tapia, Andrea, Saupe, Erin, Thuiller, Wilfried, Varela, Sara, Warren, Dan, Wieczorek, John, Yates, Katherine, Zhu, Gengping, Zuquim, Gabriela, and Zurell, Damaris

Subjects
Ecological niche model, Species distribution model, Course, Open access, Methods
Abstract

The field of distributional ecology has seen considerable recent attention, particularly surrounding the theory, protocols, and tools for Ecological Niche Modeling (ENM) or Species Distribution Modeling (SDM). Such analyses have grown steadily over the past two decades—including a maturation of relevant theory and key concepts—but methodological consensus has yet to be reached. In response, and following an online course taught in Spanish in 2018, we designed a comprehensive English-language course covering much of the underlying theory and methods currently applied in this broad field. Here, we summarize that course, ENM2020, and provide links by which resources produced for it can be accessed into the future. ENM2020 lasted 43 weeks, with presentations from 52 instructors, who engaged with >2500 participants globally through >14,000 hours of viewing and >90,000 views of instructional video and question-and-answer sessions. Each major topic was introduced by an “Overview” talk, followed by more detailed lectures on subtopics. The hierarchical and modular format of the course permits updates, corrections, or alternative viewpoints, and generally facilitates revision and reuse, including the use of only the Overview lectures for introductory courses. All course materials are free and openly accessible (CC-BY license) to ensure these resources remain available to all interested in distributional ecology.

Published
2022

12. Harnessing the NEON data revolution to advance open environmental science with a diverse and data‐capable community

Author

Nagy, R Chelsea, Balch, Jennifer K, Bissell, Erin K, Cattau, Megan E, Glenn, Nancy F, Halpern, Benjamin S, Ilangakoon, Nayani, Johnson, Brian, Joseph, Maxwell B, Marconi, Sergio, O’Riordan, Catherine, Sanovia, James, Swetnam, Tyson L, Travis, William R, Wasser, Leah A, Woolner, Elizabeth, Zarnetske, Phoebe, Abdulrahim, Mujahid, Adler, John, Barnes, Grenville, Bartowitz, Kristina J, Blake, Rachael E, Bombaci, Sara P, Brun, Julien, Buchanan, Jacob D, Chadwick, K Dana, Chapman, Melissa S, Chong, Steven S, Chung, Y Anny, Corman, Jessica R, Couret, Jannelle, Crispo, Erika, Doak, Thomas G, Donnelly, Alison, Duffy, Katharyn A, Dunning, Kelly H, Duran, Sandra M, Edmonds, Jennifer W, Fairbanks, Dawson E, Felton, Andrew J, Florian, Christopher R, Gann, Daniel, Gebhardt, Martha, Gill, Nathan S, Gram, Wendy K, Guo, Jessica S, Harvey, Brian J, Hayes, Katherine R, Helmus, Matthew R, Hensley, Robert T, Hondula, Kelly L, Huang, Tao, Hundertmark, Wiley J, Iglesias, Virginia, Jacinthe, Pierre‐Andre, Jansen, Lara S, Jarzyna, Marta A, Johnson, Tiona M, Jones, Katherine D, Jones, Megan A, Just, Michael G, Kaddoura, Youssef O, Kagawa‐Vivani, Aurora K, Kaushik, Aleya, Keller, Adrienne B, King, Katelyn BS, Kitzes, Justin, Koontz, Michael J, Kouba, Paige V, Kwan, Wai‐Yin, LaMontagne, Jalene M, LaRue, Elizabeth A, Li, Daijiang, Li, Bonan, Lin, Yang, Liptzin, Daniel, Long, William Alex, Mahood, Adam L, Malloy, Samuel S, Malone, Sparkle L, McGlinchy, Joseph M, Meier, Courtney L, Melbourne, Brett A, Mietkiewicz, Nathan, Morisette, Jeffery T, Moustapha, Moussa, Muscarella, Chance, Musinsky, John, Muthukrishnan, Ranjan, Naithani, Kusum, Neely, Merrie, Norman, Kari, Parker, Stephanie M, Rocha, Mariana Perez, Petri, Laís, Ramey, Colette A, Record, Sydne, Rossi, Matthew W, SanClements, Michael, and Scholl, Victoria M

Subjects
Quality Education, community, continental-scale ecology, diversity, inclusion, National Ecological Observatory Network, open data, open science, Special Feature, Harnessing the Neon Data Revolution, Ecological Applications, Ecology, Zoology
Abstract

It is a critical time to reflect on the National Ecological Observatory Network (NEON) science to date as well as envision what research can be done right now with NEON (and other) data and what training is needed to enable a diverse user community. NEON became fully operational in May 2019 and has pivoted from planning and construction to operation and maintenance. In this overview, the history of and foundational thinking around NEON are discussed. A framework of open science is described with a discussion of how NEON can be situated as part of a larger data constellation—across existing networks and different suites of ecological measurements and sensors. Next, a synthesis of early NEON science, based on >100 existing publications, funded proposal efforts, and emergent science at the very first NEON Science Summit (hosted by Earth Lab at the University of Colorado Boulder in October 2019) is provided. Key questions that the ecology community will address with NEON data in the next 10 yr are outlined, from understanding drivers of biodiversity across spatial and temporal scales to defining complex feedback mechanisms in human–environmental systems. Last, the essential elements needed to engage and support a diverse and inclusive NEON user community are highlighted: training resources and tools that are openly available, funding for broad community engagement initiatives, and a mechanism to share and advertise those opportunities. NEON users require both the skills to work with NEON data and the ecological or environmental science domain knowledge to understand and interpret them. This paper synthesizes early directions in the community’s use of NEON data, and opportunities for the next 10 yr of NEON operations in emergent science themes, open science best practices, education and training, and community building.

Published
2021

14. Basin-wide variation in tree hydraulic safety margins predicts the carbon balance of Amazon forests

Author

Tavares, Julia Valentim, Oliveira, Rafael S., Mencuccini, Maurizio, Signori-Müller, Caroline, Pereira, Luciano, Diniz, Francisco Carvalho, Gilpin, Martin, Marca Zevallos, Manuel J., Salas Yupayccana, Carlos A., Acosta, Martin, Pérez Mullisaca, Flor M., Barros, Fernanda de V., Bittencourt, Paulo, Jancoski, Halina, Scalon, Marina Corrêa, Marimon, Beatriz S., Oliveras Menor, Imma, Marimon, Jr, Ben Hur, Fancourt, Max, Chambers-Ostler, Alexander, Esquivel-Muelbert, Adriane, Rowland, Lucy, Meir, Patrick, Lola da Costa, Antonio Carlos, Nina, Alex, Sanchez, Jesus M. B., Tintaya, Jose S., Chino, Rudi S. C., Baca, Jean, Fernandes, Leticia, Cumapa, Edwin R. M., Santos, João Antônio R., Teixeira, Renata, Tello, Ligia, Ugarteche, Maira T. M., Cuellar, Gina A., Martinez, Franklin, Araujo-Murakami, Alejandro, Almeida, Everton, da Cruz, Wesley Jonatar Alves, del Aguila Pasquel, Jhon, Aragāo, Luís, Baker, Timothy R., de Camargo, Plinio Barbosa, Brienen, Roel, Castro, Wendeson, Ribeiro, Sabina Cerruto, Coelho de Souza, Fernanda, Cosio, Eric G., Davila Cardozo, Nallaret, da Costa Silva, Richarlly, Disney, Mathias, Espejo, Javier Silva, Feldpausch, Ted R., Ferreira, Leandro, Giacomin, Leandro, Higuchi, Niro, Hirota, Marina, Honorio, Euridice, Huaraca Huasco, Walter, Lewis, Simon, Flores Llampazo, Gerardo, Malhi, Yadvinder, Monteagudo Mendoza, Abel, Morandi, Paulo, Chama Moscoso, Victor, Muscarella, Robert, Penha, Deliane, Rocha, Mayda Cecília, Rodrigues, Gleicy, Ruschel, Ademir R., Salinas, Norma, Schlickmann, Monique, Silveira, Marcos, Talbot, Joey, Vásquez, Rodolfo, Vedovato, Laura, Vieira, Simone Aparecida, Phillips, Oliver L., Gloor, Emanuel, and Galbraith, David R.

Published
2023
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15. Lattice compression increases the activation barrier for phase segregation in mixed-halide perovskites

Author

Muscarella, Loreta A., Hutter, Eline M., Wittmann, Francesca, Woo, Young Won, Jung, Young-Kwang, McGovern, Lucie, Versluis, Jan, Walsh, Aron, Bakker, Huib J., and Ehrler, Bruno

Subjects
Physics - Applied Physics, Condensed Matter - Materials Science, Physics - Chemical Physics
Abstract

The bandgap tunability of mixed-halide perovskites makes them promising candidates for light emitting diodes and tandem solar cells. However, illuminating mixed-halide perovskites results in the formation of segregated phases enriched in a single-halide. This segregation occurs through ion migration, which is also observed in single-halide compositions, and whose control is thus essential to enhance the lifetime and stability. Using pressure-dependent transient absorption spectroscopy, we find that the formation rates of both iodide- and bromide-rich phases in MAPb(BrxI1-x)3 reduce by two orders of magnitude on increasing the pressure to 0.3 GPa. We explain this reduction from a compression-induced increase of the activation energy for halide migration, which is supported by first-principle calculations. A similar mechanism occurs when the unit cell volume is reduced by incorporating a smaller cation. These findings reveal that stability with respect to halide segregation can be achieved either physically through compressive stress or chemically through compositional engineering.

Published
2020

16. The impact of exciton delocalization on exciton-vibration interactions in organic semiconductors

Author

Alvertis, Antonios M., Pandya, Raj, Muscarella, Loreta A., Sawhney, Nipun, Nguyen, Malgorzata, Ehrler, Bruno, Rao, Akshay, Friend, Richard H., Chin, Alex W., and Monserrat, Bartomeu

Subjects
Condensed Matter - Materials Science, Physics - Chemical Physics, Physics - Computational Physics
Abstract

Organic semiconductors exhibit properties of individual molecules and extended crystals simultaneously. The strongly bound excitons they host are typically described in the molecular limit, but excitons can delocalize over many molecules, raising the question of how important the extended crystalline nature is. Using accurate Green's function based methods for the electronic structure and non-perturbative finite difference methods for exciton-vibration coupling, we describe exciton interactions with molecular and crystal degrees of freedom concurrently. We find that the degree of exciton delocalization controls these interactions, with thermally activated crystal phonons predominantly coupling to delocalized states, and molecular quantum fluctuations predominantly coupling to localized states. Based on this picture, we quantitatively predict and interpret the temperature and pressure dependence of excitonic peaks in the acene series of organic semiconductors, which we confirm experimentally, and we develop a simple experimental protocol for probing exciton delocalization. Overall, we provide a unified picture of exciton delocalization and vibrational effects in organic semiconductors, reconciling the complementary views of finite molecular clusters and periodic molecular solids.

Published
2020
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17. Clinicopathologic Features and Response to Therapy of NRG1 Fusion-Driven Lung Cancers: The eNRGy1 Global Multicenter Registry.

Author

Drilon, Alexander, Duruisseaux, Michael, Han, Ji-Youn, Ito, Masaoki, Falcon, Christina, Yang, Soo-Ryum, Murciano-Goroff, Yonina, Chen, Haiquan, Okada, Morihito, Molina, Miguel, Wislez, Marie, Brun, Philippe, Dupont, Clarisse, Branden, Eva, Rossi, Giulio, Schrock, Alexa, Ali, Siraj, Gounant, Valérie, Magne, Fanny, Blum, Torsten, Schram, Alison, Monnet, Isabelle, Shih, Jin-Yuan, Sabari, Joshua, Pérol, Maurice, Zhu, Viola, Nagasaka, Misako, Doebele, Robert, Camidge, D, Arcila, Maria, Ou, Sai-Hong, Moro-Sibilot, Denis, Rosell, Rafael, Muscarella, Lucia, Liu, Stephen, and Cadranel, Jacques

Subjects
Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Asia, Biomarkers, Tumor, Europe, Female, Follow-Up Studies, Humans, Immunotherapy, Lung Neoplasms, Male, Middle Aged, Neuregulin-1, Oncogene Proteins, Fusion, Prognosis, Registries, Retrospective Studies, Survival Rate, United States
Abstract

PURPOSE: Although NRG1 fusions are oncogenic drivers across multiple tumor types including lung cancers, these are difficult to study because of their rarity. The global eNRGy1 registry was thus established to characterize NRG1 fusion-positive lung cancers in the largest and most diverse series to date. METHODS: From June 2018 to February 2020, a consortium of 22 centers from nine countries in Europe, Asia, and the United States contributed data from patients with pathologically confirmed NRG1 fusion-positive lung cancers. Profiling included DNA-based and/or RNA-based next-generation sequencing and fluorescence in situ hybridization. Anonymized clinical, pathologic, molecular, and response (RECIST v1.1) data were centrally curated and analyzed. RESULTS: Although the typified never smoking (57%), mucinous adenocarcinoma (57%), and nonmetastatic (71%) phenotype predominated in 110 patients with NRG1 fusion-positive lung cancer, further diversity, including in smoking history (43%) and histology (43% nonmucinous and 6% nonadenocarcinoma), was elucidated. RNA-based testing identified most fusions (74%). Molecularly, six (of 18) novel 5 partners, 20 unique epidermal growth factor domain-inclusive chimeric events, and heterogeneous 5/3 breakpoints were found. Platinum-doublet and taxane-based (post-platinum-doublet) chemotherapy achieved low objective response rates (ORRs 13% and 14%, respectively) and modest progression-free survival medians (PFS 5.8 and 4.0 months, respectively). Consistent with a low programmed death ligand-1 expressing (28%) and low tumor mutational burden (median: 0.9 mutations/megabase) immunophenotype, the activity of chemoimmunotherapy and single-agent immunotherapy was poor (ORR 0%/PFS 3.3 months and ORR 20%/PFS 3.6 months, respectively). Afatinib achieved an ORR of 25%, not contingent on fusion type, and a 2.8-month median PFS. CONCLUSION: NRG1 fusion-positive lung cancers were molecularly, pathologically, and clinically more heterogeneous than previously recognized. The activity of cytotoxic, immune, and targeted therapies was disappointing. Further research examining NRG1-rearranged tumor biology is needed to develop new therapeutic strategies.

Published
2021

18. Thermodynamic stabilization of mixed-halide perovskites against phase segregation

Author

Hutter, Eline M., Muscarella, Loreta A., Wittmann, Francesca, Versluis, Jan, McGovern, Lucie, Bakker, Huib J., Woo, Young-Won, Jung, Young-Kwang, Walsh, Aron, and Ehrler, Bruno

Subjects
Physics - Chemical Physics
Abstract

Mixing iodide and bromide in halide perovskite semiconductors is an effective strategy to tune their bandgap, therefore mixed-halide perovskites hold great promise for color-tunable LEDs and tandem solar cells. However, the bandgap of mixed-halide perovskites is unstable under (sun-)light, since the halides segregate into domains of different bandgaps. Using pressure-dependent ultrafast transient absorption spectroscopy, we show that high external pressure increases the range of thermodynamically stable halide mixing ratios. Chemical pressure, by inserting a smaller cation, has the same effect, which means that any iodide-to-bromide ratio can be thermodynamically stabilized by tuning the crystal volume and compressibility. We interpret this stabilization by an alteration of the Helmholtz free energy via the largely overlooked PdeltaV term.

Published
2020
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19. Crystal orientation and grain size: do they determine optoelectronic properties of MAPbI3 perovskite?

Author

Muscarella, Loreta A., Hutter, Eline M., Sanchez, Sandy, Dieleman, Christian D., Savenije, Tom J., Hagfeldt, Anders, Saliba, Michael, and Ehrler, Bruno

Subjects
Physics - Applied Physics, Condensed Matter - Materials Science
Abstract

It is thought that growing large, oriented grains of perovskite can lead to more efficient devices. We study MAPbI3 films fabricated via Flash Infrared Annealing (FIRA) consisting of highly oriented, large grains. Domains observed in the SEM are often misidentified with crystallographic grains, but SEM images don't provide diffraction information. We measure the grain size, crystal structure and grain orientation using Electron Back-Scattered Diffraction (EBSD) and we study how these affect the optoelectronic properties as characterized by local photoluminescence (PL) and time-resolved microwave conductivity measurements (TRMC). We find a spherulitic growth yielding large (tens of micron), highly oriented grains along the (112) and (400) planes in contrast to randomly oriented, smaller (400 nm) grains observed in films fabricated via conventional antisolvent (AS) dripping. We observe a local enhancement and shift of the photoluminescence emission at different regions of the FIRA clusters, but these can be explained with a combination of light-outcoupling and self-absorption. We observe no effect of crystal orientation on the optoelectronic properties. Additionally, despite a substantial difference in grain size between our FIRA sample and a conventional AS sample, we find similar photoluminescence and charge carrier mobilities and lifetime for the two films. These findings show that the optoelectronic quality is not necessarily related to the orientation and size of crystalline domains in perovskite films indicating that fabrication requirements may be more relaxed for perovskites.

Published
2019

20. Local Crystal Misorientation Influences Non-Radiative Recombination

Author

Jariwala, Sarthak, Sun, Hongyu, Adhyaksa, Gede W. P., Lof, Andries, Muscarella, Loreta A., Ehrler, Bruno, Garnett, Erik C., and Ginger, David S.

Subjects
Condensed Matter - Materials Science
Abstract

We use ultrasensitive electron backscatter diffraction (EBSD) to map the local crystal orientations, grains, and grain boundaries in CH3NH3PbI3 (MAPI) perovskite thin films. Although the true grain structure is broadly consistent with the morphology visible in scanning electron microscopy (SEM), the inverse pole figure maps taken with EBSD reveal grain structure and internal misorientation that is otherwise hidden. Local crystal misorientation is consistent with the presence of local strain which varies from one grain to the next. We acquire co-aligned confocal optical photoluminescence (PL) microscopy images on the same MAPI samples used for EBSD. We correlate optical and EBSD data, showing that PL is anticorrelated with the local grain orientation spread, suggesting that grains with higher degrees of crystalline orientational heterogeneity (local strain) exhibit more non-radiative recombination. We find that larger grains tend to have larger grain orientation spread, consistent with higher degrees of strain and non-radiative recombination.

Published
2019
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21. Metagenomes from Experimental Hydrologic Manipulation of Restored Coastal Plain Wetland Soils (Tyrell County, North Carolina)

Author

Peralta, Ariane L, Bledsoe, Regina B, Muscarella, Mario E, Huntemann, Marcel, Clum, Alicia, Foster, Brian, Foster, Bryce, Roux, Simon, Palaniappan, Krishnaveni, Varghese, Neha, Mukherjee, Supratim, Reddy, TBK, Daum, Chris, Copeland, Alex, Chen, I-Min A, Ivanova, Natalia N, Kyrpides, Nikos C, del Rio, Tijana Glavina, and Eloe-Fadrosh, Emiley A

Subjects
Biological Sciences, Ecology, Biochemistry and Cell Biology, Genetics, Microbiology
Abstract

Hydrologic changes modify microbial community structure and ecosystem functions, especially in wetland systems. Here, we present 24 metagenomes from a coastal freshwater wetland experiment in which we manipulated hydrologic conditions and plant presence. These wetland soil metagenomes will deepen our understanding of how hydrology and vegetation influence microbial functional diversity.

Published
2020

22. The global abundance of tree palms

Author

Muscarella, R, Emilio, T, Phillips, OL, Lewis, SL, Slik, F, Baker, WJ, Couvreur, TLP, Eiserhardt, WL, Svenning, JC, Affum-Baffoe, K, Aiba, SI, de Almeida, EC, de Almeida, SS, de Oliveira, EA, Álvarez-Dávila, E, Alves, LF, Alvez-Valles, CM, Carvalho, FA, Guarin, FA, Andrade, A, Aragão, LEOC, Murakami, AA, Arroyo, L, Ashton, PS, Corredor, GAA, Baker, TR, de Camargo, PB, Barlow, J, Bastin, JF, Bengone, NN, Berenguer, E, Berry, N, Blanc, L, Böhning-Gaese, K, Bonal, D, Bongers, F, Bradford, M, Brambach, F, Brearley, FQ, Brewer, SW, Camargo, JLC, Campbell, DG, Castilho, CV, Castro, W, Catchpole, D, Cerón Martínez, CE, Chen, S, Chhang, P, Cho, P, Chutipong, W, Clark, C, Collins, M, Comiskey, JA, Medina, MNC, Costa, FRC, Culmsee, H, David-Higuita, H, Davidar, P, del Aguila-Pasquel, J, Derroire, G, Di Fiore, A, Van Do, T, Doucet, JL, Dourdain, A, Drake, DR, Ensslin, A, Erwin, T, Ewango, CEN, Ewers, RM, Fauset, S, Feldpausch, TR, Ferreira, J, Ferreira, LV, Fischer, M, Franklin, J, Fredriksson, GM, Gillespie, TW, Gilpin, M, Gonmadje, C, Gunatilleke, AUN, Hakeem, KR, Hall, JS, Hamer, KC, Harris, DJ, Harrison, RD, Hector, A, Hemp, A, Herault, B, Pizango, CGH, Coronado, ENH, Hubau, W, Hussain, MS, Ibrahim, FH, Imai, N, Joly, CA, Joseph, S, Anitha, K, Kartawinata, K, Kassi, J, and Killeen, TJ

Subjects
above-ground biomass, abundance patterns, Arecaceae, local abiotic conditions, Neotropics, pantropical biogeography, tropical rainforest, wood density, Ecology, Physical Geography and Environmental Geoscience, Ecological Applications
Abstract

Aim: Palms are an iconic, diverse and often abundant component of tropical ecosystems that provide many ecosystem services. Being monocots, tree palms are evolutionarily, morphologically and physiologically distinct from other trees, and these differences have important consequences for ecosystem services (e.g., carbon sequestration and storage) and in terms of responses to climate change. We quantified global patterns of tree palm relative abundance to help improve understanding of tropical forests and reduce uncertainty about these ecosystems under climate change. Location: Tropical and subtropical moist forests. Time period: Current. Major taxa studied: Palms (Arecaceae). Methods: We assembled a pantropical dataset of 2,548 forest plots (covering 1,191 ha) and quantified tree palm (i.e., ≥10 cm diameter at breast height) abundance relative to co-occurring non-palm trees. We compared the relative abundance of tree palms across biogeographical realms and tested for associations with palaeoclimate stability, current climate, edaphic conditions and metrics of forest structure. Results: On average, the relative abundance of tree palms was more than five times larger between Neotropical locations and other biogeographical realms. Tree palms were absent in most locations outside the Neotropics but present in >80% of Neotropical locations. The relative abundance of tree palms was more strongly associated with local conditions (e.g., higher mean annual precipitation, lower soil fertility, shallower water table and lower plot mean wood density) than metrics of long-term climate stability. Life-form diversity also influenced the patterns; palm assemblages outside the Neotropics comprise many non-tree (e.g., climbing) palms. Finally, we show that tree palms can influence estimates of above-ground biomass, but the magnitude and direction of the effect require additional work. Conclusions: Tree palms are not only quintessentially tropical, but they are also overwhelmingly Neotropical. Future work to understand the contributions of tree palms to biomass estimates and carbon cycling will be particularly crucial in Neotropical forests.

Published
2020

24. Quantification of Ion Migration in CH3NH3PbI3 Perovskite Solar Cells by Transient Capacitance Measurements

Author

Futscher, Moritz H., Lee, Ju Min, McGovern, Lucie, Muscarella, Loreta A., Wang, Tianyi, Haider, Muhammad Irfan, Fakharuddin, Azhar, Schmidt-Mende, Lukas, and Ehrler, Bruno

Subjects
Condensed Matter - Materials Science
Abstract

Solar cells based on organic-inorganic metal halide perovskites show efficiencies close to highly-optimized silicon solar cells. However, ion migration in the perovskite films leads to device degradation and impedes large scale commercial applications. We use transient ion-drift measurements to quantify activation energy, diffusion coefficient, and concentration of mobile ions in methylammonium lead triiodide (MAPbI3) perovskite solar cells, and find that their properties change close to the tetragonal-to-orthorhombic phase transition temperature. We identify three migrating ion species which we attribute to the migration of iodide (I-) and methylammonium (MA+). We find that the concentration of mobile MA+ ions is one order of magnitude higher than the one of mobile I- ions, and that the diffusion coefficient of mobile MA+ ions is three orders of magnitude lower than the one for mobile I- ions. We furthermore observe that the activation energy of mobile I- ions (0.29 eV) is highly reproducible for different devices, while the activation energy of mobile MA+ depends strongly on device fabrication. This quantification of mobile ions in MAPbI3 will lead to a better understanding of ion migration and its role in operation and degradation of perovskite solar cells.

Published
2018
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25. Legume abundance along successional and rainfall gradients in Neotropical forests

Author

Gei, Maga, Rozendaal, Danaë MA, Poorter, Lourens, Bongers, Frans, Sprent, Janet I, Garner, Mira D, Aide, T Mitchell, Andrade, José Luis, Balvanera, Patricia, Becknell, Justin M, Brancalion, Pedro HS, Cabral, George AL, César, Ricardo Gomes, Chazdon, Robin L, Cole, Rebecca J, Colletta, Gabriel Dalla, de Jong, Ben, Denslow, Julie S, Dent, Daisy H, DeWalt, Saara J, Dupuy, Juan Manuel, Durán, Sandra M, do Espírito Santo, Mário Marcos, Fernandes, G Wilson, Nunes, Yule Roberta Ferreira, Finegan, Bryan, Moser, Vanessa Granda, Hall, Jefferson S, Hernández-Stefanoni, José Luis, Junqueira, André B, Kennard, Deborah, Lebrija-Trejos, Edwin, Letcher, Susan G, Lohbeck, Madelon, Marín-Spiotta, Erika, Martínez-Ramos, Miguel, Meave, Jorge A, Menge, Duncan NL, Mora, Francisco, Muñoz, Rodrigo, Muscarella, Robert, Ochoa-Gaona, Susana, Orihuela-Belmonte, Edith, Ostertag, Rebecca, Peña-Claros, Marielos, Pérez-García, Eduardo A, Piotto, Daniel, Reich, Peter B, Reyes-García, Casandra, Rodríguez-Velázquez, Jorge, Romero-Pérez, I Eunice, Sanaphre-Villanueva, Lucía, Sanchez-Azofeifa, Arturo, Schwartz, Naomi B, de Almeida, Arlete Silva, Almeida-Cortez, Jarcilene S, Silver, Whendee, de Souza Moreno, Vanessa, Sullivan, Benjamin W, Swenson, Nathan G, Uriarte, Maria, van Breugel, Michiel, van der Wal, Hans, Veloso, Maria das Dores Magalhães, Vester, Hans FM, Vieira, Ima Célia Guimarães, Zimmerman, Jess K, and Powers, Jennifer S

Subjects
Biological Sciences, Ecology, Central America, Fabaceae, Forests, Population Density, Puerto Rico, Rain, South America, Trees, Evolutionary biology, Environmental management
Abstract

The nutrient demands of regrowing tropical forests are partly satisfied by nitrogen-fixing legume trees, but our understanding of the abundance of those species is biased towards wet tropical regions. Here we show how the abundance of Leguminosae is affected by both recovery from disturbance and large-scale rainfall gradients through a synthesis of forest inventory plots from a network of 42 Neotropical forest chronosequences. During the first three decades of natural forest regeneration, legume basal area is twice as high in dry compared with wet secondary forests. The tremendous ecological success of legumes in recently disturbed, water-limited forests is likely to be related to both their reduced leaflet size and ability to fix N2, which together enhance legume drought tolerance and water-use efficiency. Earth system models should incorporate these large-scale successional and climatic patterns of legume dominance to provide more accurate estimates of the maximum potential for natural nitrogen fixation across tropical forests.

Published
2018

29. What are the type, direction, and strength of species, community, and ecosystem responses to warming in aquatic mesocosm studies and their dependency on experimental characteristics? A systematic review protocol

Author

Guy-Haim, Tamar, Alexander, Harriet, Bell, Tom W, Bier, Raven L, Bortolotti, Lauren E, Briseño-Avena, Christian, Dong, Xiaoli, Flanagan, Alison M, Grosse, Julia, Grossmann, Lars, Hasnain, Sarah, Hovel, Rachel, Johnston, Cora A, Miller, Dan R, Muscarella, Mario, Noto, Akana E, Reisinger, Alexander J, Smith, Heidi J, and Stamieszkin, Karen

Subjects
Environmental Sciences, Biological Sciences, Ecology, Climate change, Global warming, Mesocosm, Microcosm, Aquatic, Marine, Estuarine, Freshwater, Experimental design, Methodology, Environmental management
Abstract

Background: Mesocosm experiments have become increasingly popular in climate change research as they bridge the gap between small-scale, less realistic, microcosm experiments, and large-scale, more complex, natural systems. Characteristics of aquatic mesocosm designs (e.g., mesocosm volume, study duration, and replication) vary widely, potentially affecting the magnitude and direction of effect sizes measured in experiments. In this global systematic review we aim to identify the type, direction and strength of climate warming effects on aquatic species, communities and ecosystems in mesocosm experiments. Furthermore, we will investigate the context-dependency of the observed effects on several a priori determined effect moderators (ecological and methodological). Our conclusions will provide recommendations for aquatic scientists designing mesocosm experiments, as well as guidelines for interpretation of experimental results by scientists, policy-makers and the general public. Methods: We will conduct a systematic search using multiple online databases to gather evidence from the scientific literature on the effects of warming experimentally tested in aquatic mesocosms. Data from relevant studies will be extracted and used in a random effects meta-analysis to estimate the overall effect sizes of warming experiments on species performance, biodiversity and ecosystem functions. Experimental characteristics (e.g., mesocosm size and shape, replication-level, experimental duration and design, biogeographic region, community type, crossed manipulation) will be further analysed using subgroup analyses.

Published
2017

30. Ecological Dissertations in the Aquatic Sciences: An Effective Networking and Professional Development Opportunity for Early Career Aquatic Scientists

Author

Kelly, Patrick T, Bell, Tom, Reisinger, Alexander J, Spanbauer, Trisha L, Bortolotti, Lauren E, Brentrup, Jennifer A, Briseño‐Avena, Christian, Dong, Xiaoli, Flanagan, Alison M, Follett, Elizabeth M, Grosse, Julia, Guy‐Haim, Tamar, Holgerson, Meredith A, Hovel, Rachel A, Luo, Jessica Y, Millette, Nicole C, Mine, Aric, Muscarella, Mario E, Oliver, Samantha K, and Smith, Heidi J

Published
2017

31. Genomic and evolutionary classification of lung cancer in never smokers

Author

Zhang, Tongwu, Joubert, Philippe, Ansari-Pour, Naser, Zhao, Wei, Hoang, Phuc H., Lokanga, Rachel, Moye, Aaron L., Rosenbaum, Jennifer, Gonzalez-Perez, Abel, Martínez-Jiménez, Francisco, Castro, Andrea, Muscarella, Lucia Anna, Hofman, Paul, Consonni, Dario, Pesatori, Angela C., Kebede, Michael, Li, Mengying, Gould Rothberg, Bonnie E., Peneva, Iliana, Schabath, Matthew B., Poeta, Maria Luana, Costantini, Manuela, Hirsch, Daniela, Heselmeyer-Haddad, Kerstin, Hutchinson, Amy, Olanich, Mary, Lawrence, Scott M., Lenz, Petra, Duggan, Maire, Bhawsar, Praphulla M. S., Sang, Jian, Kim, Jung, Mendoza, Laura, Saini, Natalie, Klimczak, Leszek J., Islam, S. M. Ashiqul, Otlu, Burcak, Khandekar, Azhar, Cole, Nathan, Stewart, Douglas R., Choi, Jiyeon, Brown, Kevin M., Caporaso, Neil E., Wilson, Samuel H., Pommier, Yves, Lan, Qing, Rothman, Nathaniel, Almeida, Jonas S., Carter, Hannah, Ried, Thomas, Kim, Carla F., Lopez-Bigas, Nuria, Garcia-Closas, Montserrat, Shi, Jianxin, Bossé, Yohan, Zhu, Bin, Gordenin, Dmitry A., Alexandrov, Ludmil B., Chanock, Stephen J., Wedge, David C., and Landi, Maria Teresa

Published
2021
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33. Blending Resources for a Collaborative Service Project in a Professional Development School Focused on Student Learning

Author

Henry, Julie Jacobs, Tryjankowski, Anne Marie, Tybor, Debra, Brandjes, Elizabeth, Asztalos, Jessica, Smith, Kemily, and Muscarella, Michael

Abstract

Collaborative Professional Development School (PDS) relationships require financing and other supports that may not be typically included in the budgets for partnering schools and colleges. In the current economic climate, budgets are especially tight in many educational institutions. In order to sustain PDS relationships in these times, stakeholders need to find ways to blend resources to accomplish joint goals. This article describes one project that utilized the staffing power of student teachers, the purchasing power of a public school, and a small PDS mini-grant from the Canisius College Office of Educational Partnerships to create literacy intervention kits to foster student learning. Benefits for all partners are discussed, and suggestions are shared for designing collaborative projects in other PDS settings.

Published
2012

36. Comprehensive genomic profiles of small cell lung cancer

Author

George, Julie, Lim, Jing Shan, Jang, Se Jin, Cun, Yupeng, Ozretić, Luka, Kong, Gu, Leenders, Frauke, Lu, Xin, Fernández-Cuesta, Lynnette, Bosco, Graziella, Müller, Christian, Dahmen, Ilona, Jahchan, Nadine S, Park, Kwon-Sik, Yang, Dian, Karnezis, Anthony N, Vaka, Dedeepya, Torres, Angela, Wang, Maia Segura, Korbel, Jan O, Menon, Roopika, Chun, Sung-Min, Kim, Deokhoon, Wilkerson, Matt, Hayes, Neil, Engelmann, David, Pützer, Brigitte, Bos, Marc, Michels, Sebastian, Vlasic, Ignacija, Seidel, Danila, Pinther, Berit, Schaub, Philipp, Becker, Christian, Altmüller, Janine, Yokota, Jun, Kohno, Takashi, Iwakawa, Reika, Tsuta, Koji, Noguchi, Masayuki, Muley, Thomas, Hoffmann, Hans, Schnabel, Philipp A, Petersen, Iver, Chen, Yuan, Soltermann, Alex, Tischler, Verena, Choi, Chang-min, Kim, Yong-Hee, Massion, Pierre P, Zou, Yong, Jovanovic, Dragana, Kontic, Milica, Wright, Gavin M, Russell, Prudence A, Solomon, Benjamin, Koch, Ina, Lindner, Michael, Muscarella, Lucia A, la Torre, Annamaria, Field, John K, Jakopovic, Marko, Knezevic, Jelena, Castaños-Vélez, Esmeralda, Roz, Luca, Pastorino, Ugo, Brustugun, Odd-Terje, Lund-Iversen, Marius, Thunnissen, Erik, Köhler, Jens, Schuler, Martin, Botling, Johan, Sandelin, Martin, Sanchez-Cespedes, Montserrat, Salvesen, Helga B, Achter, Viktor, Lang, Ulrich, Bogus, Magdalena, Schneider, Peter M, Zander, Thomas, Ansén, Sascha, Hallek, Michael, Wolf, Jürgen, Vingron, Martin, Yatabe, Yasushi, Travis, William D, Nürnberg, Peter, Reinhardt, Christian, Perner, Sven, Heukamp, Lukas, Büttner, Reinhard, Haas, Stefan A, Brambilla, Elisabeth, Peifer, Martin, Sage, Julien, and Thomas, Roman K

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Oncology and Carcinogenesis, Women's Health, Rare Diseases, Lung Cancer, Orphan Drug, Human Genome, Cancer, Cancer Genomics, Lung, 2.1 Biological and endogenous factors, Alleles, Animals, Cell Line, Tumor, Chromosome Breakpoints, Cyclin D1, DNA-Binding Proteins, Disease Models, Animal, Female, Gene Expression Profiling, Genome, Human, Genomics, Humans, Lung Neoplasms, Male, Mice, Mutation, Neurosecretory Systems, Nuclear Proteins, Receptors, Notch, Retinoblastoma Protein, Signal Transduction, Small Cell Lung Carcinoma, Tumor Protein p73, Tumor Suppressor Protein p53, Tumor Suppressor Proteins, General Science & Technology
Abstract

We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 and RB1, sometimes by complex genomic rearrangements. Two tumours with wild-type RB1 had evidence of chromothripsis leading to overexpression of cyclin D1 (encoded by the CCND1 gene), revealing an alternative mechanism of Rb1 deregulation. Thus, loss of the tumour suppressors TP53 and RB1 is obligatory in SCLC. We discovered somatic genomic rearrangements of TP73 that create an oncogenic version of this gene, TP73Δex2/3. In rare cases, SCLC tumours exhibited kinase gene mutations, providing a possible therapeutic opportunity for individual patients. Finally, we observed inactivating mutations in NOTCH family genes in 25% of human SCLC. Accordingly, activation of Notch signalling in a pre-clinical SCLC mouse model strikingly reduced the number of tumours and extended the survival of the mutant mice. Furthermore, neuroendocrine gene expression was abrogated by Notch activity in SCLC cells. This first comprehensive study of somatic genome alterations in SCLC uncovers several key biological processes and identifies candidate therapeutic targets in this highly lethal form of cancer.

Published
2015

40. Wet and dry tropical forests show opposite successional pathways in wood density but converge over time

Author

Poorter, Lourens, Rozendaal, Danaë M. A., Bongers, Frans, de Almeida-Cortez, Jarcilene S., Almeyda Zambrano, Angélica María, Álvarez, Francisco S., Andrade, José Luís, Villa, Luis Felipe Arreola, Balvanera, Patricia, Becknell, Justin M., Bentos, Tony V., Bhaskar, Radika, Boukili, Vanessa, Brancalion, Pedro H. S., Broadbent, Eben N., César, Ricardo G., Chave, Jerome, Chazdon, Robin L., Colletta, Gabriel Dalla, Craven, Dylan, de Jong, Ben H. J., Denslow, Julie S., Dent, Daisy H., DeWalt, Saara J., García, Elisa Díaz, Dupuy, Juan Manuel, Durán, Sandra M., Espírito Santo, Mário M., Fandiño, María C., Fernandes, Geraldo Wilson, Finegan, Bryan, Moser, Vanessa Granda, Hall, Jefferson S., Hernández-Stefanoni, José Luis, Jakovac, Catarina C., Junqueira, André B., Kennard, Deborah, Lebrija-Trejos, Edwin, Letcher, Susan G., Lohbeck, Madelon, Lopez, Omar R., Marín-Spiotta, Erika, Martínez-Ramos, Miguel, Martins, Sebastião V., Massoca, Paulo E. S., Meave, Jorge A., Mesquita, Rita, Mora, Francisco, de Souza Moreno, Vanessa, Müller, Sandra C., Muñoz, Rodrigo, Muscarella, Robert, de Oliveira Neto, Silvio Nolasco, Nunes, Yule R. F., Ochoa-Gaona, Susana, Paz, Horacio, Peña-Claros, Marielos, Piotto, Daniel, Ruíz, Jorge, Sanaphre-Villanueva, Lucía, Sanchez-Azofeifa, Arturo, Schwartz, Naomi B., Steininger, Marc K., Thomas, William Wayt, Toledo, Marisol, Uriarte, Maria, Utrera, Luis P., van Breugel, Michiel, van der Sande, Masha T., van der Wal, Hans, Veloso, Maria D. M., Vester, Hans F. M., Vieira, Ima C. G., Villa, Pedro Manuel, Williamson, G. Bruce, Wright, S. Joseph, Zanini, Kátia J., Zimmerman, Jess K., and Westoby, Mark

Published
2019
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41. Pancreatic Adenocarcinoma, version 2.2012: featured updates to the NCCN Guidelines.

Author

Tempero, Margaret A, Arnoletti, J Pablo, Behrman, Stephen W, Ben-Josef, Edgar, Benson, Al B, Casper, Ephraim S, Cohen, Steven J, Czito, Brian, Ellenhorn, Joshua DI, Hawkins, William G, Herman, Joseph, Hoffman, John P, Ko, Andrew, Komanduri, Srinadh, Koong, Albert, Ma, Wen Wee, Malafa, Mokenge P, Merchant, Nipun B, Mulvihill, Sean J, Muscarella, Peter, Nakakura, Eric K, Obando, Jorge, Pitman, Martha B, Sasson, Aaron R, Tally, Anitra, Thayer, Sarah P, Whiting, Samuel, Wolff, Robert A, Wolpin, Brian M, Freedman-Cass, Deborah A, and Shead, Dorothy A

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Pancreatic Cancer, Clinical Research, Rare Diseases, Digestive Diseases, Adenocarcinoma, Antineoplastic Combined Chemotherapy Protocols, Diagnostic Imaging, Humans, Neoplasm Staging, Pancreatic Neoplasms, National Comprehensive Cancer Networks, Oncology & Carcinogenesis, Oncology and carcinogenesis, Health services and systems
Abstract

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Pancreatic Adenocarcinoma discuss the workup and management of tumors of the exocrine pancreas. These NCCN Guidelines Insights provide a summary and explanation of major changes to the 2012 NCCN Guidelines for Pancreatic Adenocarcinoma. The panel made 3 significant updates to the guidelines: 1) more detail was added regarding multiphase CT techniques for diagnosis and staging of pancreatic cancer, and pancreas protocol MRI was added as an emerging alternative to CT; 2) the use of a fluoropyrimidine plus oxaliplatin (e.g., 5-FU/leucovorin/oxaliplatin or capecitabine/oxaliplatin) was added as an acceptable chemotherapy combination for patients with advanced or metastatic disease and good performance status as a category 2B recommendation; and 3) the panel developed new recommendations concerning surgical technique and pathologic analysis and reporting.

Published
2012

42. Is Video Really Necessary? A Study Comparing Interactivity in Video and Audio Classrooms.

Author

Farr, Charlotte Webb and Muscarella, Diane

Abstract

This paper presents the findings of a study comparing the amount of interactivity generated in three different instructional settings: face-to-face instruction in a television classroom, real time instruction via microwave (two-way interactive video), and audioteleconference instruction supplemented with prerecorded videos. The study was conducted using three sessions of a psychology class, all taught by the same instructor, on the psychosocial implications of AIDS. With regard to the face-to-face with video comparison, the data suggests that the presence of the instructor, regardless of site, increases the amount of interaction. The comparison of audio/video with face-to-face instruction produced similar results; however, in the audio condition the majority of students' interactions were comments rather than questions, showing a substantively greater degree of understanding of the material. Three explanations for the differences in quality of interactions are suggested: (1) a difference in the way the class was structured; (2) a difference in the two audiences; and (3) the use of tapes representing different time periods in the class. (ALF)

Published
1991

45. Evolutionary determinants of genome-wide nucleotide composition

Author

Long, Hongan, Sung, Way, Kucukyildirim, Sibel, Williams, Emily, Miller, Samuel F., Guo, Wanfeng, Patterson, Caitlyn, Gregory, Colin, Strauss, Chloe, Stone, Casey, Berne, Cécile, Kysela, David, Shoemaker, William R., Muscarella, Mario E., Luo, Haiwei, Lennon, Jay T., Brun, Yves V., and Lynch, Michael

Published
2018
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47. Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids

Author

Alcala, N., Leblay, N., Gabriel, A. A. G., Mangiante, L., Hervas, D., Giffon, T., Sertier, A. S., Ferrari, A., Derks, J., Ghantous, A., Delhomme, T. M., Chabrier, A., Cuenin, C., Abedi-Ardekani, B., Boland, A., Olaso, R., Meyer, V., Altmuller, J., Le Calvez-Kelm, F., Durand, G., Voegele, C., Boyault, S., Moonen, L., Lemaitre, N., Lorimier, P., Toffart, A. C., Soltermann, A., Clement, J. H., Saenger, J., Field, J. K., Brevet, M., Blanc-Fournier, C., Galateau-Salle, F., Le Stang, N., Russell, P. A., Wright, G., Sozzi, G., Pastorino, U., Lacomme, S., Vignaud, J. M., Hofman, V., Hofman, P., Brustugun, O. T., Lund-Iversen, M., Thomas de Montpreville, V., Muscarella, L. A., Graziano, P., Popper, H., Stojsic, J., Deleuze, J. F., Herceg, Z., Viari, A., Nuernberg, P., Pelosi, G., Dingemans, A. M. C., Milione, M., Roz, L., Brcic, L., Volante, M., Papotti, M. G., Caux, C., Sandoval, J., Hernandez-Vargas, H., Brambilla, E., Speel, E. J. M., Girard, N., Lantuejoul, S., McKay, J. D., Foll, M., and Fernandez-Cuesta, L.

Published
2019
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48. Safety and effectiveness of tofacitinib in ulcerative colitis: Data from TOFA-UC, a SN-IBD study.

Author

Macaluso, Fabio Salvatore, D'Antonio, Elvira, Fries, Walter, Viola, Anna, Ksissa, Omar, Cappello, Maria, Muscarella, Stefano, Belluardo, Nunzio, Giangreco, Emiliano, Mocciaro, Filippo, Di Mitri, Roberto, Ferracane, Concetta, Vitello, Alessandro, Grova, Mauro, Renna, Sara, Casà, Angelo, De Vivo, Simona, Ventimiglia, Marco, and Orlando, Ambrogio

Abstract

Real-world evidence is needed to determine the value of tofacitinib (TOFA) for the treatment of ulcerative colitis (UC). To assess the safety and effectiveness of TOFA in clinical practice. TOFA-UC is a multicenter, observational study performed among the Sicilian Network for Inflammatory Bowel Disease (SN-IBD). All consecutive patients with UC starting TOFA from its introduction in Sicily (July 2021) to July 2022 were included. 111 patients were included (mean follow-up: 31.7 ± 14.9 weeks; biologic-experienced: 92.8%). Nineteen adverse events were reported (17.1%; incidence rate: 28.2 per 100 patient years), including 11 cases of hypercholesterolemia and 3 infections (no cases of herpes zoster reactivation. At week 8, the rates of clinical response, steroid free clinical remission, and CRP normalization were 74.8%, 45.0%, and 56.9%, respectively, and 68.5%, 51.4%, and 65.2%, respectively, at the end of follow-up. Eighteen patients experienced a loss of response after successful induction (21.7%; incidence rate: 33.2 per 100 patient years). Twenty-six patients (23.4%) discontinued TOFA over time, of whom 3 due to AEs, and 23 to non response or loss of response. TOFA is safe and effective in patients with UC, including those with history of multiple failures to biological therapies. [ABSTRACT FROM AUTHOR]

Published
2024
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