Search

BACKGROUND: Although the pathophysiological importance of emperipolesis is not known exactly, it has been reported to increase significantly in cases of various cancer types, different tumours and thrombosis disorders. In this study the effects of acrylamide on the frequency of megakaryocytic emperipolesis and the mitotic activity in rat bone marrow cells were determined. For this purpose, two separate experiments were performed with Sprague-Dawley rats gavaged with 0, 30, 45 and 60 mg acrylamide kg−1 body weight (BW) for five consecutive days. In the second experiment, 3 mg colchicine kg−1 BW was injected intraperitoneally 2 h before cervical dislocation. Bone marrow samples were taken 24 h after the last application in both experiments. RESULTS: It was found that only the highest dose of acrylamide significantly decreased the incidence of megakaryocytic emperipolesis and that the types of bone marrow cells engulfed by megakaryocytes were mostly neutrophil granulocytes. Neither megakaryocytes nor engulfed cells showed any morphological degeneration. In the mitotic activity experiment, doses of 45 and 60 mg acrylamide kg−1 BW decreased the mitotic activity of bone marrow cells in comparison with the control group. CONCLUSION: It was concluded that the decrease in megakaryocytic emperipolesis frequency might be a consequence of the decrease in mitotic activity in bone marrow cells. Copyright © 2011 Society of Chemical Industry

2nd World Conference on Educational Sciences (WCES-2010) -- FEB 04-08, 2010 -- Bahceschir Univ, Istanbul, TURKEY, WOS: 000282002800124, The purpose of this study is to investigate biology student teachers' conceptions of learning. This study focuses on the following question: How do biology student teachers conceptualize the term "learning"? A total of 86 biology students, who were studying to become secondary biology teachers at the education faculty of a university in Turkey, participated in this study. To reveal participating students' conceptions of learning they were asked to answer the open-ended question: "What is learning?''. Data obtained from the question was analyzed and the frequencies of the responses were classified in six categories. The results of this study have shown that the variation of participating students' conceptions of learning includes all of six conceptions of learning identified originally by Marton et al. (1993). Participants focused mainly on the conceptions of learning as the increase of knowledge and learning as the acquisition of facts or procedures. These results are compared with related literature and recommendations are provided. (C) 2010 Elsevier Ltd. All rights reserved.

The aim of this research is to investigate student science teachers’ opinions about the causes of degradation of ecosystems and the effects of such degradations on the environment. This research focuses on the following questions: What kind of descriptions do student science teachers ascribe to the reasons of degradation in ecosystems? What are the effects of ecosystem degradations on the environment? What are the misconceptions in relation to degradations in ecosystems? A total of 130 participating students, who were studying to become science teachers at Faculty of Education of Necmettin Erbakan University in Turkey, participated in this study. To reveal the participating students’ opinions about the reasons for degradations in ecosystems and their effects on the environment, they were asked to answer two open questions: (1) What are the reasons for degradations in ecosystems? (2) What are the effects of degradations in ecosystems on the environment? The participants were asked to answer these two questions. Data obtained from the questions were analyzed and the frequencies of the answers were classified in different categories. Moreover, these included some misconceptions such as ‘the greenhouse effect can lead to skin cancer’ and ‘ozone layer depletion leads to global warming’. The findings are compared with related literature and suggestions are presented.

3rd World Conference on Educational Sciences (WCES) -- FEB 03-07, 2011 -- Bahcesehir Univ, Istanbul, TURKEY, WOS: 000466750602120, The purpose of this study is to investigate science student teachers' ideas about the 'gene' concept. This study focuses on the following questions: What kind of descriptions do science student teachers ascribe to gene? What categories can be derived from these descriptions in terms of common features? A total of 140 participating students, who were studying to become primary science teachers at the Ahmet Kelesoglu Faculty of Education of Selcuk University in Turkey, participated in this study. To reveal participating students' ideas about the 'gene' concept they were asked to respond two open questions: (1) What is a gene in your opinion? (2) The participating students were asked to complete a free word association test. In the test, the term 'gene' was presented as a stimulus word. Data obtained from the questions were analyzed and the frequencies of the responses were classified in different categories. The results are compared with related literature and recommendations are provided., Ankara Univ, Near E Univ

Although the pathophysiological importance of emperipolesis is not known exactly, it has been reported to increase significantly in cases of various cancer types, different tumours and thrombosis disorders. In this study the effects of acrylamide on the frequency of megakaryocytic emperipolesis and the mitotic activity in rat bone marrow cells were determined. For this purpose, two separate experiments were performed with Sprague-Dawley rats gavaged with 0, 30, 45 and 60 mg acrylamide kg⁻¹ body weight (BW) for five consecutive days. In the second experiment, 3 mg colchicine kg⁻¹ BW was injected intraperitoneally 2 h before cervical dislocation. Bone marrow samples were taken 24 h after the last application in both experiments.It was found that only the highest dose of acrylamide significantly decreased the incidence of megakaryocytic emperipolesis and that the types of bone marrow cells engulfed by megakaryocytes were mostly neutrophil granulocytes. Neither megakaryocytes nor engulfed cells showed any morphological degeneration. In the mitotic activity experiment, doses of 45 and 60 mg acrylamide kg⁻¹ BW decreased the mitotic activity of bone marrow cells in comparison with the control group.It was concluded that the decrease in megakaryocytic emperipolesis frequency might be a consequence of the decrease in mitotic activity in bone marrow cells.