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The photoredox amination of arene protocols mostly comprises photocatalyst-mediated transformations. Herein, we presented the photocatalyst-free, visible-light promoted, direct conversion of C(sp2)–H to C(sp2)–N method. Multipurpose benzothiadiazoles are used as model synthons and secondary amines as aminating agents. Mechanistic study reveals that the radical reaction mechanism proceeds through nitrogen-centered radical generation, followed by the addition of arenes, which was demonstrated for the present amination protocol of benzothiadiazole with secondary amines in an atom economical fashion. [ABSTRACT FROM AUTHOR]

Unsupervised segmentation is a significant pre‐processing task in various computer visualization processes. However, recently used unsupervised segmentation methods are very sensitive to few of the parameters like number of segmentation or numerous training and more inference complication. Neurodegenerative disorders namely Parkinson's and Alzheimer's, add up to main aspects to longer disability and has grown to be a more serious concept in the developed nations. At present, there does not exist efficient therapies. Earlier diagnosis along with avoiding misdiagnosis significantly assists in ensuring a good quality for patient's life. Hence, adopting computer‐aided‐diagnosis tools provides clinical assistance. This paper focus on detecting neurodegenerative disease from CT brain images by segmentation through region splitting based segmentation with deep unsupervised neural networks (RSS‐DUNN).Auto encoder deep neural network is constructed with reconstruction process of input image, which further improves the accuracy. The performance of the proposed model is evaluated by comparing it with two standard methods in terms of accuracy, precision, recall, Jaccard similarity index (JSI) and dice similarity coefficient (DSC). As a result, it achieves 70.4% of accuracy, 70.8% of precision, 75.8% of recall, 73.6% of JSI and 81% of DSC. [ABSTRACT FROM AUTHOR]

Herein, we disclose a ruthenium‐catalyzed regioselective β‐C(sp3)−H bond functionalization on the piperazine core using aldehydes as alkylating agents. The present transformation appears to go through the dehydrogenation of the piperazine to propagate to enamine in situ, followed by nucleophilic addition to the aldehyde and hydrogenation to result in the regioselective β‐C(sp3)−H alkylation. A variety of aromatic, heteroaromatic, aliphatic aldehydes were employed for the C‐3 alkylation of N‐alkyl‐N′‐p‐nitrophenyl substituted piperazines. [ABSTRACT FROM AUTHOR]

Byline: P.D.D. Dominic, Ahmad Kamil Mahmood, V. Murugesh, P. Sridevi Today's global business environment, characterised by unprecedented competitive pressures and sophisticated customers that demand speedy solutions, creates a large set of potential suppliers to evaluate and select from. The business landscape is currently witnessing widespread migration of services and functions from developed nations like the USA to destinations like India, China, the Philippines, Malaysia, Singapore, Hungary, Poland, New Zealand and other countries. Several factors influence the outsourcers to offshore effectively and efficiently. This paper presents a structured framework with subjective and objective factors for guiding the outsourcers in making the decision on the proper outsourcing location. Based on this, a Decision Support System (DSS) framework was developed to provide a way for outsourcers and practitioners to have a more comprehensive approach to the outsourcing location decision. The process illustrates the way the system aids management in the offshore outsourcing decision through knowledge support.

β-C(sp3)–H functionalization on the ‘privileged’ piperazine nucleus has been disclosed using ruthenium catalysis. The ruthenium catalyzed synthesis of a variety of piperazine fused indoles from ortho-piperazinyl (hetero)aryl aldehydes is presented. This transformation takes place via the dehydrogenation of piperazine followed by an intramolecular nucleophilic addition of the transient enamine moiety onto the carbonyl group and aromatization cascade. [ABSTRACT FROM AUTHOR]