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2. Data from Pyrvinium Targets CD133 in Human Glioblastoma Brain Tumor–Initiating Cells

Author

Venugopal, Chitra, primary, Hallett, Robin, primary, Vora, Parvez, primary, Manoranjan, Branavan, primary, Mahendram, Sujeivan, primary, Qazi, Maleeha A., primary, McFarlane, Nicole, primary, Subapanditha, Minomi, primary, Nolte, Sara M., primary, Singh, Mohini, primary, Bakhshinyan, David, primary, Garg, Neha, primary, Vijayakumar, Thusyanth, primary, Lach, Boleslaw, primary, Provias, John P., primary, Reddy, Kesava, primary, Murty, Naresh K., primary, Doble, Bradley W., primary, Bhatia, Mickie, primary, Hassell, John A., primary, and Singh, Sheila K., primary

Published
2023
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4. Supplementary Figures 1-6 from Pyrvinium Targets CD133 in Human Glioblastoma Brain Tumor–Initiating Cells

Author

Venugopal, Chitra, primary, Hallett, Robin, primary, Vora, Parvez, primary, Manoranjan, Branavan, primary, Mahendram, Sujeivan, primary, Qazi, Maleeha A., primary, McFarlane, Nicole, primary, Subapanditha, Minomi, primary, Nolte, Sara M., primary, Singh, Mohini, primary, Bakhshinyan, David, primary, Garg, Neha, primary, Vijayakumar, Thusyanth, primary, Lach, Boleslaw, primary, Provias, John P., primary, Reddy, Kesava, primary, Murty, Naresh K., primary, Doble, Bradley W., primary, Bhatia, Mickie, primary, Hassell, John A., primary, and Singh, Sheila K., primary

Published
2023
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7. Supplementary Tables 1-6 from Pyrvinium Targets CD133 in Human Glioblastoma Brain Tumor–Initiating Cells

Author

Venugopal, Chitra, primary, Hallett, Robin, primary, Vora, Parvez, primary, Manoranjan, Branavan, primary, Mahendram, Sujeivan, primary, Qazi, Maleeha A., primary, McFarlane, Nicole, primary, Subapanditha, Minomi, primary, Nolte, Sara M., primary, Singh, Mohini, primary, Bakhshinyan, David, primary, Garg, Neha, primary, Vijayakumar, Thusyanth, primary, Lach, Boleslaw, primary, Provias, John P., primary, Reddy, Kesava, primary, Murty, Naresh K., primary, Doble, Bradley W., primary, Bhatia, Mickie, primary, Hassell, John A., primary, and Singh, Sheila K., primary

Published
2023
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9. STEM-05. FUNCTIONAL MAPPING REVEALS WIDESPREAD REMODELLING AND UNRECOGNIZED PATHWAY DEPENDENCIES IN RECURRENT GLIOBLASTOMA

Author

Chokshi, Chirayu R, primary, Tieu, David, additional, Brown, Kevin R, additional, Venugopal, Chitra, additional, Liu, Lina, additional, Kuhlmann, Laura, additional, Rossotti, Martin A, additional, Chan, Katherine, additional, Tong, Amy H Y, additional, Savage, Neil, additional, McKenna, Dillon, additional, Aghaei, Nikoo, additional, Subapanditha, Minomi, additional, Vaseem Shaikh, Muhammad, additional, Tatari, Nazanin, additional, Brakel, Benjamin, additional, Nachmani, Omri, additional, Ignatchenko, Vladimir, additional, Salamoun, Joseph M, additional, Wipf, Peter, additional, Sharlow, Elizabeth, additional, Provias, John P, additional, Lu, Jian-Qiang, additional, Murty, Naresh K, additional, Lazo, John S, additional, Kislinger, Thomas, additional, Henry, Kevin A, additional, Lu, Yu, additional, Moffat, Jason, additional, and Singh, Sheila K, additional

Published
2021
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10. Endovascular Thrombectomy for Acute Ischemic Stroke: A Meta-analysis

Author

Badhiwala, Jetan H., Nassiri, Farshad, Alhazzani, Waleed, Selim, Magdy H., Farrokhyar, Forough, Spears, Julian, Kulkarni, Abhaya V., Singh, Sheila, Alqahtani, Abdulrahman, Rochwerg, Bram, Alshahrani, Mohammad, Murty, Naresh K., Alhazzani, Adel, Yarascavitch, Blake, Reddy, Kesava, Zaidat, Osama O., and Almenawer, Saleh A.

Published
2015
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14. Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent Glioblastoma.

Author

Qazi, Maleeha A, Vora, Parvez, Venugopal, Chitra, Adams, Jarrett, Singh, Mohini, Hu, Amy, Gorelik, Maryna, Subapanditha, Minomi K, Savage, Neil, Yang, Jiahe, Chokshi, Chirayu, London, Max, Gont, Alexander, Bobrowski, David, Grinshtein, Natalie, Brown, Kevin R, Murty, Naresh K, Nilvebrant, Johan, Kaplan, David, Moffat, Jason, Sidhu, Sachdev, Singh, Sheila K, Qazi, Maleeha A, Vora, Parvez, Venugopal, Chitra, Adams, Jarrett, Singh, Mohini, Hu, Amy, Gorelik, Maryna, Subapanditha, Minomi K, Savage, Neil, Yang, Jiahe, Chokshi, Chirayu, London, Max, Gont, Alexander, Bobrowski, David, Grinshtein, Natalie, Brown, Kevin R, Murty, Naresh K, Nilvebrant, Johan, Kaplan, David, Moffat, Jason, Sidhu, Sachdev, and Singh, Sheila K

Abstract

Glioblastoma (GBM) carries a dismal prognosis and inevitably relapses despite aggressive therapy. Many members of the Eph receptor tyrosine kinase (EphR) family are expressed by GBM stem cells (GSC), which have been implicated in resistance to GBM therapy. In this study, we identify several EphRs that mark a therapeutically targetable GSC population in treatment-refractory, recurrent GBM (rGBM). Using a highly specific EphR antibody panel and CyTOF (cytometry by time-of-flight), we characterized the expression of all 14 EphR in primary and recurrent patient-derived GSCs to identify putative rGBM-specific EphR. EPHA2 and EPHA3 coexpression marked a highly tumorigenic cell population in rGBM that was enriched in GSC marker expression. Knockdown of EPHA2 and EPHA3 together led to increased expression of differentiation marker GFAP and blocked clonogenic and tumorigenic potential, promoting significantly higher survival in vivo Treatment of rGBM with a bispecific antibody against EPHA2/A3 reduced clonogenicity in vitro and tumorigenic potential of xenografted recurrent GBM in vivo via downregulation of AKT and ERK and increased cellular differentiation. In conclusion, we show that EPHA2 and EPHA3 together mark a GSC population in rGBM and that strategic cotargeting of EPHA2 and EPHA3 presents a novel and rational therapeutic approach for rGBM.Significance: Treatment of rGBM with a novel bispecific antibody against EPHA2 and EPHA3 reduces tumor burden, paving the way for the development of therapeutic approaches against biologically relevant targets in rGBM. Cancer Res; 78(17); 5023-37. ©2018 AACR., QC 20201119

Published
2018
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15. Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent Glioblastoma

Author

Qazi, Maleeha A., primary, Vora, Parvez, additional, Venugopal, Chitra, additional, Adams, Jarrett, additional, Singh, Mohini, additional, Hu, Amy, additional, Gorelik, Maryna, additional, Subapanditha, Minomi K., additional, Savage, Neil, additional, Yang, Jiahe, additional, Chokshi, Chirayu, additional, London, Max, additional, Gont, Alexander, additional, Bobrowski, David, additional, Grinshtein, Natalie, additional, Brown, Kevin R., additional, Murty, Naresh K., additional, Nilvebrant, Johan, additional, Kaplan, David, additional, Moffat, Jason, additional, Sidhu, Sachdev, additional, and Singh, Sheila K., additional

Published
2018
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17. Abstract 44: Characterization and targeting of a temporal micro-metastatic signature in human brain metastases

Author

Singh, Mohini, primary, Venugopal, Chitra, additional, Tokar, Tomas, additional, McFarlane, Nicole, additional, Subhapanditha, Minomi, additional, Bakhshinyan, David, additional, Qazi, Maleeha, additional, Vora, Parvez, additional, Savage, Neil, additional, Murty, Naresh K., additional, Jurisica, Igor, additional, and Singh, Sheila K., additional

Published
2018
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18. Identification and Co-Targeting of EphA2/EphA3 Cancer Stem Cells in Recurrent Human Glioblastoma

Author

Qazi, Maleeha A., primary, Vora, Parvez, additional, Venugopal, Chitra, additional, Adams, Jarrett, additional, Singh, Mohini, additional, Hu, Amy, additional, Gorelik, Maryna, additional, Yang, Jiahe, additional, Chokshi, Chirayu, additional, London, Max, additional, Subapanditha, Minomi, additional, Gont, Alexander, additional, Bobrowski, David, additional, Grinshtein, Natalie, additional, Brown, Kevin R., additional, Murty, Naresh K., additional, Nilvebrant, Johan, additional, Kaplan, David, additional, Moffat, Jason, additional, Sidhu, Sachdev, additional, and Singh, Sheila K., additional

Published
2018
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19. The identification of human pituitary adenoma-initiating cells

Author

Manoranjan, Branavan, primary, Mahendram, Sujeivan, additional, Almenawer, Saleh A., additional, Venugopal, Chitra, additional, McFarlane, Nicole, additional, Hallett, Robin, additional, Vijayakumar, Thusyanth, additional, Algird, Almunder, additional, Murty, Naresh K., additional, Sommer, Doron D., additional, Provias, John P., additional, Reddy, Kesava, additional, and Singh, Sheila K., additional

Published
2016
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20. Pyrvinium Targets CD133 in Human Glioblastoma Brain Tumor–Initiating Cells

Author

Venugopal, Chitra, primary, Hallett, Robin, additional, Vora, Parvez, additional, Manoranjan, Branavan, additional, Mahendram, Sujeivan, additional, Qazi, Maleeha A., additional, McFarlane, Nicole, additional, Subapanditha, Minomi, additional, Nolte, Sara M., additional, Singh, Mohini, additional, Bakhshinyan, David, additional, Garg, Neha, additional, Vijayakumar, Thusyanth, additional, Lach, Boleslaw, additional, Provias, John P., additional, Reddy, Kesava, additional, Murty, Naresh K., additional, Doble, Bradley W., additional, Bhatia, Mickie, additional, Hassell, John A., additional, and Singh, Sheila K., additional

Published
2015
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21. A novel stem cell culture model of recurrent glioblastoma

Author

Qazi, Maleeha A., primary, Vora, Parvez, additional, Venugopal, Chitra, additional, McFarlane, Nicole, additional, Subapanditha, Minomi K., additional, Murty, Naresh K., additional, Hassell, John A., additional, Hallett, Robin M., additional, and Singh, Sheila K., additional

Published
2015
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22. STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation

Author

Singh, Mohini, primary, Garg, Neha, additional, Venugopal, Chitra, additional, Hallett, Robin, additional, Tokar, Tomas, additional, McFarlane, Nicole, additional, Mahendram, Sujeivan, additional, Bakhshinyan, David, additional, Manoranjan, Branavan, additional, Vora, Parvez, additional, Qazi, Maleeha, additional, Arpin, Carolynn C., additional, Page, Brent, additional, Haftchenary, Sina, additional, Rosa, David A., additional, Lai, Ping-Shan, additional, Gómez-Biagi, Rodolfo F., additional, Ali, Ahmed M., additional, Lewis, Andrew, additional, Geletu, Mulu, additional, Murty, Naresh K., additional, Hassell, John A., additional, Jurisica, Igor, additional, Gunning, Patrick T., additional, and Singh, Sheila K., additional

Published
2015
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