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4. Incidence of bloodstream infections due to multidrug-resistant pathogens in ordinary wards and intensive care units before and during the COVID-19 pandemic: a real-life, retrospective observational study

Author

Segala, Francesco Vladimiro, Pafundi, Pia Clara, Masciocchi, Carlotta, Fiori, Barbara, Taddei, Eleonora, Antenucci, Laura, De Angelis, Giulia, Guerriero, Silvia, Pastorino, Roberta, Damiani, Andrea, Posteraro, Brunella, Sanguinetti, Maurizio, De Pascale, Gennaro, Fantoni, Massimo, and Murri, Rita

Published
2023
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6. Sarilumab plus standard of care vs standard of care for the treatment of severe COVID-19: a phase 3, randomized, open-labeled, multi-center study (ESCAPE study)

Author

Agrati, Chiara, Andreoni, Massimo, Antinori, Andrea, Bai, Francesca, Beccacece, Alessia, Barreca, Filippo, Bertuccio, Maria Paola, Bini, Teresa, Boumis, Evangelo, Camici, Marta, Cauda, Roberto, Cerva, Carlotta, Cicalini, Stefania, Cingolani, Antonella, D'Arminio Monforte, Antonella, D'Urso, Angela, De Masi, Margherita, De Zottis, Federico, Del Borgo, Cosmo, Di Gennaro, Francesco, Emiliozzi, Arianna, Fantoni, Massimo, Fondaco, Laura, Fusto, Marisa, Gagliardini, Roberta, Giovannenze, Francesca, Grilli, Elisabetta, Iannetta, Marco, Iodice, Daniele, Lichtner, Miriam, Lorenzini, Patrizia, Maffongelli, Gaetano, Masone, Erminia, Massa, Barbara, Mastrorosa, Ilaria, Mazzotta, Valentina, Mencarini, Paola, Milozzi, Eugenia, Mondi, Annalisa, Mosti, Silvia, Murri, Rita, Negri, Marcantonio, Nicastri, Emanuele, Oliva, Gian Piero, Onnelli, Giovanna, Ottou, Sandrine, Pace, Pier Giorgio, Palmieri, Fabrizio, Paulicelli, Jessica, Pinnetti, Carmela, Plazzi, Maria Maddalena, Sarmati, Loredana, Segala, Francesco Vladimiro, Sorace, Chiara, Taddei, Eleonora, Vergori, Alessandra, Vitale, Pietro, Lamonica, Silvia, Girardi, Enrico, and Vaia, Francesco

Published
2023
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7. A Machine Learning Predictive Model of Bloodstream Infection in Hospitalized Patients

Author

Murri, Rita, De Angelis, Giulia, Antenucci, Laura, Fiori Alfarano, Barbara, Rinaldi, Riccardo, Fantoni, Massimo, Damiani, Andrea, Patarnello, Stefano, Sanguinetti, Maurizio, Valentini, Vincenzo, Posteraro, Brunella, Masciocchi, Carlotta, Murri, Rita (ORCID:0000-0003-4263-7854), De Angelis, Giulia (ORCID:0000-0002-7087-7399), Fiori, Barbara (ORCID:0000-0003-3318-5809), Fantoni, Massimo (ORCID:0000-0001-6913-8460), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Valentini, Vincenzo (ORCID:0000-0003-4637-6487), Posteraro, Brunella (ORCID:0000-0002-1663-7546), Murri, Rita, De Angelis, Giulia, Antenucci, Laura, Fiori Alfarano, Barbara, Rinaldi, Riccardo, Fantoni, Massimo, Damiani, Andrea, Patarnello, Stefano, Sanguinetti, Maurizio, Valentini, Vincenzo, Posteraro, Brunella, Masciocchi, Carlotta, Murri, Rita (ORCID:0000-0003-4263-7854), De Angelis, Giulia (ORCID:0000-0002-7087-7399), Fiori, Barbara (ORCID:0000-0003-3318-5809), Fantoni, Massimo (ORCID:0000-0001-6913-8460), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Valentini, Vincenzo (ORCID:0000-0003-4637-6487), and Posteraro, Brunella (ORCID:0000-0002-1663-7546)

Abstract

The aim of the study was to build a machine learning-based predictive model to discriminate between hospitalized patients at low risk and high risk of bloodstream infection (BSI). A Data Mart including all patients hospitalized between January 2016 and December 2019 with suspected BSI was built. Multivariate logistic regression was applied to develop a clinically interpretable machine learning predictive model. The model was trained on 2016-2018 data and tested on 2019 data. A feature selection based on a univariate logistic regression first selected candidate predictors of BSI. A multivariate logistic regression with stepwise feature selection in five-fold cross-validation was applied to express the risk of BSI. A total of 5660 hospitalizations (4026 and 1634 in the training and the validation subsets, respectively) were included. Eleven predictors of BSI were identified. The performance of the model in terms of AUROC was 0.74. Based on the interquartile predicted risk score, 508 (31.1%) patients were defined as being at low risk, 776 (47.5%) at medium risk, and 350 (21.4%) at high risk of BSI. Of them, 14.2% (72/508), 30.8% (239/776), and 64% (224/350) had a BSI, respectively. The performance of the predictive model of BSI is promising. Computational infrastructure and machine learning models can help clinicians identify people at low risk for BSI, ultimately supporting an antibiotic stewardship approach.

Published
2024

8. Ursodeoxycholic acid does not affect the clinical outcome of SARS-CoV-2 infection: A retrospective study of propensity score-matched cohorts

Author

Marrone, Giuseppe, Covino, Marcello, Merra, Giuseppe, Piccioni, Andrea, Amodeo, Annamaria, Novelli, Angela, Murri, Rita, Pompili, Maurizio, Gasbarrini, Antonio, Franceschi, Francesco, Covino, Marcello (ORCID:0000-0002-6709-2531), Murri, Rita (ORCID:0000-0003-4263-7854), Pompili, Maurizio (ORCID:0000-0001-6699-7980), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Franceschi, Francesco (ORCID:0000-0001-6266-445X), Marrone, Giuseppe, Covino, Marcello, Merra, Giuseppe, Piccioni, Andrea, Amodeo, Annamaria, Novelli, Angela, Murri, Rita, Pompili, Maurizio, Gasbarrini, Antonio, Franceschi, Francesco, Covino, Marcello (ORCID:0000-0002-6709-2531), Murri, Rita (ORCID:0000-0003-4263-7854), Pompili, Maurizio (ORCID:0000-0001-6699-7980), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), and Franceschi, Francesco (ORCID:0000-0001-6266-445X)

Abstract

Background: Ursodeoxycholic acid (UDCA) has been recently proposed as a modulator of angiotensin-converting enzyme 2 (ACE2) receptor expression, with potential effects on COVID-19.Aim and Study Design: We retrospectively evaluated the clinical course and outcome of subjects taking UDCA admitted to the hospital for COVID-19 compared with matched infected subjects. Differences regarding the severity and outcome of the disease between treated and non-treated subjects were assessed. The Kaplan-Meier survival analysis and log-rank test were used to evaluate the effect of UDCA on all-cause intra-hospital mortality.Results: Among 6444 subjects with confirmed COVID-19 admitted to the emergency department (ED) from 1 March 2020 to 31 December 2022, 109 subjects were taking UDCA. After matching 629 subjects were included in the study: 521 in the no UDCA group and 108 in the UDCA group. In our matched cohort, 144 subjects (22.9%) died, 118 (22.6%) in the no-UDCA group and 26 (24.1%) in the UDCA group. The Kaplan-Meier analysis showed no significant difference in survival between groups. In univariate regression analysis, the presence of pneumonia, National Early Warning Score (NEWS) score, and Charlson Comorbidity Index (CCI) were significant independent predictors of death. At multivariate Cox regression analysis, age, NEWS, pneumonia and CCI index were confirmed significant independent predictors of death. UDCA treatment was not a predictor of survival both in univariate and multivariate regressions.Conclusions: UDCA treatment does not appear to have significant effects on the outcome of COVID-19. Specially designed prospective studies are needed to evaluate efficacy in preventing infection and severe disease.

Published
2024

9. Association of piperacillin/tazobactam MIC and mortality in a cohort of ceftriaxone-resistant Escherichia coli bloodstream infections treated with piperacillin/tazobactam and carbapenems: a multicentric propensity score-weighted observational cohort study

Author

Rando, Emanuele, Salvati, Federica, Sangiorgi, Flavio, Catania, Francesca, Leone, Elisa, Oliva, Alessandra, Di Gennaro, Francesco, Fiori, Barbara, Cancelli, Francesca, Figliomeni, Sara, Bobbio, Francesca, Sacco, Federica, Bavaro, Davide Fiore, Diella, Lucia, Belati, Alessandra, Saracino, Annalisa, Mastroianni, Claudio Maria, Fantoni, Massimo, Murri, Rita, Fiori, Barbara (ORCID:0000-0003-3318-5809), Fantoni, Massimo (ORCID:0000-0001-6913-8460), Murri, Rita (ORCID:0000-0003-4263-7854), Rando, Emanuele, Salvati, Federica, Sangiorgi, Flavio, Catania, Francesca, Leone, Elisa, Oliva, Alessandra, Di Gennaro, Francesco, Fiori, Barbara, Cancelli, Francesca, Figliomeni, Sara, Bobbio, Francesca, Sacco, Federica, Bavaro, Davide Fiore, Diella, Lucia, Belati, Alessandra, Saracino, Annalisa, Mastroianni, Claudio Maria, Fantoni, Massimo, Murri, Rita, Fiori, Barbara (ORCID:0000-0003-3318-5809), Fantoni, Massimo (ORCID:0000-0001-6913-8460), and Murri, Rita (ORCID:0000-0003-4263-7854)

Abstract

Objectives To assess the impact of piperacillin/tazobactam MICs on in-hospital 30 day mortality in patients with third-generation cephalosporin-resistant Escherichia coli bloodstream infection treated with piperacillin/tazobactam, compared with those treated with carbapenems.Methods A multicentre retrospective cohort study was conducted in three large academic hospitals in Italy between 2018 and 2022. The study population comprised patients with monomicrobial third-generation cephalosporin-resistant E. coli bloodstream infection, who received either piperacillin/tazobactam or carbapenem therapy within 48 h of blood culture collection. The primary outcome was in-hospital 30 day all-cause mortality. A propensity score was used to estimate the likelihood of receiving empirical piperacillin/tazobactam treatment. Cox regression models were performed to ascertain risk factors independently associated with in-hospital 30 day mortality.Results Of the 412 consecutive patients included in the study, 51% received empirical therapy with piperacillin/tazobactam, while 49% received carbapenem therapy. In the propensity-adjusted multiple Cox model, the Pitt bacteraemia score [HR 1.38 (95% CI, 0.85-2.16)] and piperacillin/tazobactam MICs of 8 mg/L [HR 2.35 (95% CI, 1.35-3.95)] and >= 16 mg/L [HR 3.69 (95% CI, 1.86-6.91)] were significantly associated with increased in-hospital 30 day mortality, while the empirical use of piperacillin/tazobactam was not found to predict in-hospital 30 day mortality [HR 1.38 (95% CI, 0.85-2.16)].Conclusions Piperacillin/tazobactam use might not be associated with increased mortality in treating third-generation cephalosporin-resistant E. coli bloodstream infections when the MIC is <8 mg/L.

Published
2024

10. Vaccines and Myocardial Injury in Patients Hospitalized for COVID-19 Infection: the CardioCOVID-Gemelli Study

Author

Montone, Rocco Antonio, Rinaldi, Riccardo, Masciocchi, Carlotta, Lilli, Livia, Damiani, Andrea, La Vecchia, Giulia, Iannaccone, Giulia, Basile, Mattia, Salzillo, Carmine, Caff, Andrea, Bonanni, Alice, De Pascale, Gennaro, Grieco, Domenico Luca, Tanzarella, Eloisa Sofia, Buonsenso, Danilo, Murri, Rita, Fantoni, Massimo, Liuzzo, Giovanna, Sanna, Tommaso, Richeldi, Luca, Sanguinetti, Maurizio, Massetti, Massimo, Trani, Carlo, Tshomba, Yamume, Gasbarrini, Antonio, Valentini, Vincenzo, Antonelli, Massimo, Crea, Filippo, De Pascale, Gennaro (ORCID:0000-0002-8255-0676), Grieco, Domenico Luca (ORCID:0000-0002-4557-6308), Murri, Rita (ORCID:0000-0003-4263-7854), Fantoni, Massimo (ORCID:0000-0001-6913-8460), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Sanna, Tommaso (ORCID:0000-0002-5760-6885), Richeldi, Luca (ORCID:0000-0001-8594-1448), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Massetti, Massimo (ORCID:0000-0002-7100-8478), Trani, Carlo (ORCID:0000-0001-9777-013X), Tshomba, Yamume (ORCID:0000-0001-7304-7553), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Valentini, Vincenzo (ORCID:0000-0003-4637-6487), Antonelli, Massimo (ORCID:0000-0003-3007-1670), Crea, Filippo (ORCID:0000-0001-9404-8846), Montone, Rocco Antonio, Rinaldi, Riccardo, Masciocchi, Carlotta, Lilli, Livia, Damiani, Andrea, La Vecchia, Giulia, Iannaccone, Giulia, Basile, Mattia, Salzillo, Carmine, Caff, Andrea, Bonanni, Alice, De Pascale, Gennaro, Grieco, Domenico Luca, Tanzarella, Eloisa Sofia, Buonsenso, Danilo, Murri, Rita, Fantoni, Massimo, Liuzzo, Giovanna, Sanna, Tommaso, Richeldi, Luca, Sanguinetti, Maurizio, Massetti, Massimo, Trani, Carlo, Tshomba, Yamume, Gasbarrini, Antonio, Valentini, Vincenzo, Antonelli, Massimo, Crea, Filippo, De Pascale, Gennaro (ORCID:0000-0002-8255-0676), Grieco, Domenico Luca (ORCID:0000-0002-4557-6308), Murri, Rita (ORCID:0000-0003-4263-7854), Fantoni, Massimo (ORCID:0000-0001-6913-8460), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Sanna, Tommaso (ORCID:0000-0002-5760-6885), Richeldi, Luca (ORCID:0000-0001-8594-1448), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Massetti, Massimo (ORCID:0000-0002-7100-8478), Trani, Carlo (ORCID:0000-0001-9777-013X), Tshomba, Yamume (ORCID:0000-0001-7304-7553), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Valentini, Vincenzo (ORCID:0000-0003-4637-6487), Antonelli, Massimo (ORCID:0000-0003-3007-1670), and Crea, Filippo (ORCID:0000-0001-9404-8846)

Abstract

Background: Myocardial injury is prevalent among patients hospitalized for COVID-19. However, the role of COVID-19 vaccines in modifying the risk of myocardial injury is unknown. Objectives: To assess the role of vaccines in modifying the risk of myocardial injury in COVID-19. Methods: We enrolled COVID-19 patients admitted from March 2021 to February 2022 with known vaccination status and ≥1 assessment of hs-cTnI within 30 days from the admission. The primary endpoint was the occurrence of myocardial injury (hs-cTnI levels >99th percentile upper reference limit). Results: 1019 patients were included (mean age 67.7±14.8 years, 60.8% male, 34.5% vaccinated against COVID-19). Myocardial injury occurred in 145 (14.2%) patients. At multivariate logistic regression analysis, advanced age, chronic kidney disease and hypertension, but not vaccination status, were independent predictors of myocardial injury. In the analysis according to age tertiles distribution, myocardial injury occurred more frequently in the III tertile (≥76 years) compared to other tertiles (I tertile:≤60 years;II tertile:61-75 years) (p<0.001). Moreover, in the III tertile, vaccination was protective against myocardial injury (OR 0.57, CI 95% 0.34-0.94; p=0.03), while a previous history of coronary artery disease was an independent positive predictor. In contrast, in the I tertile, chronic kidney disease (OR 6.94, 95% CI 1.31-36.79, p=0.02) and vaccination (OR 4.44, 95% CI 1.28-15.34, p=0.02) were independent positive predictors of myocardial injury. Conclusions: In patients ≥76 years, COVID-19 vaccines were protective for the occurrence of myocardial injury, while in patients ≤60 years, myocardial injury was associated with previous COVID-19 vaccination. Further studies are warranted to clarify the underlying mechanisms.

Published
2024

11. Fatigue in Covid-19 survivors: The potential impact of a nutritional supplement on muscle strength and function

Author

Steering Committee, Landi, Francesco, Gremese, Elisa, Coordination, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Field investigators, Gastroenterology team, Porcari, Serena, Settanni, Carlo Romano, Geriatric team, Benvenuto, Francesca, Bramato, Giulia, Brandi, Vincenzo, Carfì, Angelo, Ciciarello, Francesca, Fabrizi, Sofia, Galluzzo, Vincenzo, Lo Monaco, Maria Rita, Martone, Anna Maria, Marzetti, Emanuele, Napolitano, Carmen, Pagano, Francesco Cosimo, Pais, Cristina, Rocchi, Sara, Rota, Elisabetta, Salerno, Andrea, Tosato, Matteo, Tritto, Marcello, Zazzara, Maria Beatrice, Calvani, Riccardo, Catalano, Lucio, Picca, Anna, Savera, Giulia, Damiano, Francesco Paolo, Rocconi, Alessandra, Galliani, Alessandro, Spaziani, Giovanni, Tupputi, Salvatore, Cocchi, Camilla, Pirone, Flavia, D'Ignazio, Federica, Cacciatore, Stefano, Infectious disease team, Cauda, Roberto, Tamburrini, Enrica, Borghetti, A., Di Gianbenedetto, Simona, Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, E., Moschese, D., Ciccullo, A., Dusina, A., Internal Medicine team, Stella, Leonardo, Addolorato, Giovanni, Franceschi, Francesco, Mingrone, Gertrude, Zocco, M.A., Microbiology team, Sanguinetti, Maurizio, Cattani, Paola, Marchetti, Simona, Posteraro, Brunella, Sali, M., Neurology team, Bizzarro, Alessandra, Lauria, Alessandra, Ophthalmology team, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, G., Cozzupoli, G.M., Culiersi, C., Otolaryngology team, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, Crudo, F., Di Cintio, G., Longobardi, Y., Tricarico, L., Santantonio, M., Pediatric team, Buonsenso, Danilo, Valentini, P., Pata, D., Sinatti, D., De Rose, C., Pneumology team, Richeldi, Luca, Lombardi, Francesco, Calabrese, A., Leone, Paolo Maria, Calvello, Maria Rosaria, Intini, Enrica, Montemurro, Giuliano, Psychiatric team, Sani, Gabriele, Janiri, Delfina, Simonetti, Alessio, Giuseppin, G., Molinaro, M., odica, M., Radiology team, Natale, Luigi, Larici, Anna Rita, Marano, Riccardo, Rheumatology team, Paglionico, Annamaria, Petricca, Luca, Gigante, Luca, Natalello, G., Fedele, A.L., Lizzio, M.M., Tolusso, B., Di Mario, Clara, Alivernini, S., Vascular team, Santoliquido, Angelo, Santoro, Luca, Di Giorgio, Angela, Nesci, Antonio, and Popolla, V.

Published
2022
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12. Impact of antimalarial resistance and COVID-19 pandemic on malaria care among pregnant women in Northern Uganda (ERASE): protocol of a prospective observational study

Author

Segala, Francesco Vladimiro, Di Gennaro, Francesco, Ictho, Jerry, L’Episcopia, Mariangela, Onapa, Emmanuel, Marotta, Claudia, De Vita, Elda, Amone, James, Iacobelli, Valentina, Ogwang, Joseph, Dall’Oglio, Giovanni, Ngole, Benedict, Murri, Rita, Olal, Lameck, Fantoni, Massimo, Okori, Samuel, Putoto, Giovanni, Severini, Carlo, Lochoro, Peter, and Saracino, Annalisa

Published
2022
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13. A real-time integrated framework to support clinical decision making for covid-19 patients

Author

Murri, Rita, Masciocchi, Carlotta, Lenkowicz, Jacopo, Fantoni, Massimo, Damiani, Andrea, Marchetti, Antonio, Sergi, Paolo Domenico Angelo, Arcuri, Giovanni, Cesario, Alfredo, Patarnello, Stefano, Antonelli, Massimo, Bellantone, Rocco, Bernabei, Roberto, Boccia, Stefania, Calabresi, Paolo, Cambieri, Andrea, Cauda, Roberto, Colosimo, Cesare, Crea, Filippo, De Maria, Ruggero, De Stefano, Valerio, Franceschi, Francesco, Gasbarrini, Antonio, Landolfi, Raffaele, Parolini, Ornella, Richeldi, Luca, Sanguinetti, Maurizio, Urbani, Andrea, Zega, Maurizio, Scambia, Giovanni, and Valentini, Vincenzo

Published
2022
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14. Effectiveness of the autumn 2023 COVID-19 vaccine dose in hospital-based healthcare workers: results of the VEBIS healthcare worker vaccine effectiveness cohort study, seven European countries, season 2023/24.

Author

Savulescu, Camelia, Prats-Uribe, Albert, Brolin, Kim, Uusküla, Anneli, Bergin, Colm, Fleming, Catherine, Murri, Rita, Zvirbulis, Viesturs, Zavadska, Dace, Gaio, Vania, Popescu, Corneliu P., Hrisca, Raluca, Cisneros, Maria, LatorreMillán, Miriam, Lohur, Liis, McGrath, Jonathan, Ferguson, Lauren, De Gaetano Donati, Katleen, Abolina, Ilze, and Gravele, Dagne

Published
2024
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16. Comparative Mortality Analysis in Febrile and Afebrile Emergency Department Patients with Positive Blood Cultures: A Retrospective Study.

Author

Bonadia, Nicola, Della Polla, Davide Antonio, Murri, Rita, D'Inzeo, Tiziana, Fiori, Barbara, Carnicelli, Annamaria, Piccioni, Andrea, Fuorlo, Mariella, Petrucci, Martina, Saviano, Angela, Gasbarrini, Antonio, Franceschi, Francesco, and Covino, Marcello

Subjects
HOSPITAL emergency services, DEATH rate, ODDS ratio, UNIVERSITY hospitals, COLLEGE majors
Abstract

This retrospective analysis at a major Italian university hospital (January 2018–September 2022) assessed the prognostic significance of fever in patients with bloodstream infections (BSIs). Of the 1299 patients with positive blood cultures, a comparison between febrile and afebrile patients at emergency department admission was conducted. This study particularly focused on the mortality rates associated with these two groups. Notably, afebrile patients exhibited a higher mortality rate. The odds ratio for mortality in afebrile patients was significantly higher compared to febrile patients. This suggests that the absence of fever might be an indicator of increased mortality risk, highlighting the complexity of diagnosing bloodstream infections based on fever presence. This study contributes to the understanding of fever as a diagnostic marker in emergency settings. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Characteristic of IgA and IgG antibody response to SARS-CoV-2 infection in an Italian referral COVID-19 Hospital

Author

Carnicelli, Annamaria, Fiori, Barbara, Ricci, Rosalba, Piano, Alfonso, Bonadia, Nicola, Taddei, Eleonora, Fantoni, Massimo, Murri, Rita, Cingolani, Antonella, Barillaro, Christian, Cutuli, Salvatore Lucio, Marchesini, Debora, Della Polla, Davide Antonio, Forte, Evelina, Fuorlo, Mariella, Di Maurizio, Luca, Amorini, Paola, Cattani, Paola, Franceschi, Francesco, and Sanguinetti, Maurizio

Published
2022
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20. Sarilumab use in severe SARS-CoV-2 pneumonia

Author

Gremese, Elisa, Cingolani, Antonella, Bosello, Silvia Laura, Alivernini, Stefano, Tolusso, Barbara, Perniola, Simone, Landi, Francesco, Pompili, Maurizio, Murri, Rita, Santoliquido, Angelo, Garcovich, Matteo, Sali, Michela, De Pascale, Gennaro, Gabrielli, Maurizio, Biscetti, Federico, Montalto, Massimo, Tosoni, Alberto, Gambassi, Giovanni, Rapaccini, Gian Ludovico, Iaconelli, Amerigo, Zileri Del Verme, Lorenzo, Petricca, Luca, Fedele, Anna Laura, Lizzio, Marco Maria, Tamburrini, Enrica, Natalello, Gerlando, Gigante, Laura, Bruno, Dario, Verardi, Lucrezia, Taddei, Eleonora, Calabrese, Angelo, Lombardi, Francesco, Bernabei, Roberto, Cauda, Roberto, Franceschi, Francesco, Landolfi, Raffaele, Richeldi, Luca, Sanguinetti, Maurizio, Fantoni, Massimo, Antonelli, Massimo, and Gasbarrini, Antonio

Published
2020
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22. Vaccines and Myocardial Injury in Patients Hospitalized for COVID-19 Infection: the CardioCOVID-Gemelli Study

Author

Montone, Rocco Antonio, primary, Rinaldi, Riccardo, additional, Masciocchi, Carlotta, additional, Lilli, Livia, additional, Damiani, Andrea, additional, La Vecchia, Giulia, additional, Iannaccone, Giulia, additional, Basile, Mattia, additional, Salzillo, Carmine, additional, Caff, Andrea, additional, Bonanni, Alice, additional, De Pascale, Gennaro, additional, Grieco, Domenico Luca, additional, Tanzarella, Eloisa Sofia, additional, Buonsenso, Danilo, additional, Murri, Rita, additional, Fantoni, Massimo, additional, Liuzzo, Giovanna, additional, Sanna, Tommaso, additional, Richeldi, Luca, additional, Sanguinetti, Maurizio, additional, Massetti, Massimo, additional, Trani, Carlo, additional, Tshomba, Yamume, additional, Gasbarrini, Antonio, additional, Valentini, Vincenzo, additional, Antonelli, Massimo, additional, and Crea, Filippo, additional

Published
2024
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23. A Machine Learning Predictive Model of Bloodstream Infection in Hospitalized Patients

Author

Murri, Rita, primary, De Angelis, Giulia, additional, Antenucci, Laura, additional, Fiori, Barbara, additional, Rinaldi, Riccardo, additional, Fantoni, Massimo, additional, Damiani, Andrea, additional, Patarnello, Stefano, additional, Sanguinetti, Maurizio, additional, Valentini, Vincenzo, additional, Posteraro, Brunella, additional, and Masciocchi, Carlotta, additional

Published
2024
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25. Association of piperacillin/tazobactam MIC and mortality in a cohort of ceftriaxone-resistant Escherichia coli bloodstream infections treated with piperacillin/tazobactam and carbapenems: a multicentric propensity score-weighted observational cohort study

Author

Rando, Emanuele, primary, Salvati, Federica, additional, Sangiorgi, Flavio, additional, Catania, Francesca, additional, Leone, Elisa, additional, Oliva, Alessandra, additional, Di Gennaro, Francesco, additional, Fiori, Barbara, additional, Cancelli, Francesca, additional, Figliomeni, Sara, additional, Bobbio, Francesca, additional, Sacco, Federica, additional, Bavaro, Davide Fiore, additional, Diella, Lucia, additional, Belati, Alessandra, additional, Saracino, Annalisa, additional, Mastroianni, Claudio Maria, additional, Fantoni, Massimo, additional, and Murri, Rita, additional

Published
2024
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27. A New Clinical Prediction Rule for Infective Endocarditis in Emergency Department Patients With Fever: Definition and First Validation of the CREED Score

Author

Covino, Marcello, De Vita, Antonio, D'Aiello, Alessia, Ravenna, Salvatore Emanuele, Ruggio, Aureliano, Genuardi, Lorenzo, Simeoni, Benedetta, Piccioni, Andrea, De Matteis, Giuseppe, Murri, Rita, Leone, Antonio Maria, Flex, Andrea, Gasbarrini, Antonio, Liuzzo, Giovanna, Massetti, Massimo, Franceschi, Francesco, Covino, Marcello (ORCID:0000-0002-6709-2531), d'Aiello, Alessia, Murri, Rita (ORCID:0000-0003-4263-7854), Leone, Antonio Maria (ORCID:0000-0002-1276-9883), Flex, Andrea (ORCID:0000-0003-2664-4165), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Massetti, Massimo (ORCID:0000-0002-7100-8478), Franceschi, Francesco (ORCID:0000-0001-6266-445X), Covino, Marcello, De Vita, Antonio, D'Aiello, Alessia, Ravenna, Salvatore Emanuele, Ruggio, Aureliano, Genuardi, Lorenzo, Simeoni, Benedetta, Piccioni, Andrea, De Matteis, Giuseppe, Murri, Rita, Leone, Antonio Maria, Flex, Andrea, Gasbarrini, Antonio, Liuzzo, Giovanna, Massetti, Massimo, Franceschi, Francesco, Covino, Marcello (ORCID:0000-0002-6709-2531), d'Aiello, Alessia, Murri, Rita (ORCID:0000-0003-4263-7854), Leone, Antonio Maria (ORCID:0000-0002-1276-9883), Flex, Andrea (ORCID:0000-0003-2664-4165), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Massetti, Massimo (ORCID:0000-0002-7100-8478), and Franceschi, Francesco (ORCID:0000-0001-6266-445X)

Abstract

Background Infective endocarditis (IE) could be suspected in any febrile patients admitted to the emergency department (ED). This study was aimed at assessing clinical criteria predictive of IE and identifying and prospectively validating a sensible and easy-to-use clinical prediction score for the diagnosis of IE in the ED. Methods and Results We conducted a retrospective observational study, enrolling consecutive patients with fever admitted to the ED between January 2015 and December 2019 and subsequently hospitalized. Several clinical and anamnestic standardized variables were collected and evaluated for the association with IE diagnosis. We derived a multivariate prediction model by logistic regression analysis. The identified predictors were assigned a score point value to obtain the Clinical Rule for Infective Endocarditis in the Emergency Department (CREED) score. To validate the CREED score we conducted a prospective observational study between January 2020 and December 2021, enrolling consecutive febrile patients hospitalized after the ED visit, and evaluating the association between the CREED score values and the IE diagnosis. A total of 15 689 patients (median age, 71 [56-81] years; 54.1% men) were enrolled in the retrospective cohort, and IE was diagnosed in 267 (1.7%). The CREED score included 12 variables: male sex, anemia, dialysis, pacemaker, recent hospitalization, recent stroke, chest pain, specific infective diagnosis, valvular heart disease, valvular prosthesis, previous endocarditis, and clinical signs of suspect endocarditis. The CREED score identified 4 risk groups for IE diagnosis, with an area under the receiver operating characteristic curve of 0.874 (0.849-0.899). The prospective cohort included 13 163 patients, with 130 (1.0%) IE diagnoses. The CREED score had an area under the receiver operating characteristic curve of 0.881 (0.848-0.913) in the validation cohort, not significantly different from the one calculated in the retrospectiv

Published
2023

28. Prevalence and Antimicrobial Resistance Patterns of Hospital Acquired Infections through the COVID-19 Pandemic: Real-Word Data from a Tertiary Urological Centre

Author

Gavi, Filippo, Fiori, Barbara, Gandi, Carlo, Campetella, Marco, Bientinesi, Riccardo, Marino, Filippo, Fettucciari, Daniele, Rossi, Francesco, Moretto, Stefano, Murri, Rita, Pierconti, Francesco, Racioppi, Marco, Sacco, Emilio, Fiori, Barbara (ORCID:0000-0003-3318-5809), Bientinesi, Riccardo (ORCID:0000-0003-0757-152X), Murri, Rita (ORCID:0000-0003-4263-7854), Pierconti, Francesco (ORCID:0000-0003-0951-4131), Racioppi, Marco (ORCID:0000-0001-9129-8479), Sacco, Emilio (ORCID:0000-0003-4640-8354), Gavi, Filippo, Fiori, Barbara, Gandi, Carlo, Campetella, Marco, Bientinesi, Riccardo, Marino, Filippo, Fettucciari, Daniele, Rossi, Francesco, Moretto, Stefano, Murri, Rita, Pierconti, Francesco, Racioppi, Marco, Sacco, Emilio, Fiori, Barbara (ORCID:0000-0003-3318-5809), Bientinesi, Riccardo (ORCID:0000-0003-0757-152X), Murri, Rita (ORCID:0000-0003-4263-7854), Pierconti, Francesco (ORCID:0000-0003-0951-4131), Racioppi, Marco (ORCID:0000-0001-9129-8479), and Sacco, Emilio (ORCID:0000-0003-4640-8354)

Abstract

Background: Antimicrobial resistance (AMR) remains a significant public health concern, closely linked to antibiotic overuse. During the COVID-19 pandemic, broad-spectrum antibiotics were frequently administered, potentially exacerbating AMR. This study aimed to assess AMR patterns in our urology department before and after the pandemic. Methods: The study encompassed patients admitted to our urology department from January 2016 to December 2022, with confirmed urinary tract infection, bloodstream infection, or wound infection based on positive culture results. Descriptive statistics, including mean, frequency, and percentage, summarized the data. Trends were analyzed using the Joinpoint Regression program. Results: A total of 506 patients were included. Escherichia coli and Klebsiella pneumoniae displayed resistance rates of 65% and 62% to ciprofloxacin, respectively. K. pneumoniae showed resistance rates of 41% to piperacillin tazobactam and 3rd generation cephalosporins (3GC). Carbapenem resistance was observed in 38% of K. pneumoniae isolates. Additionally, 26% of E. coli, 26% of K. pneumoniae, and 59% of Proteus mirabilis isolates were ESBL-positive. Among gram+, 72% of Staphylococcus aureus isolates were MRSA, and 23% of Enterococcus faecium isolates were VRE. Trends in antimicrobial susceptibility patterns over the 7-year study period revealed a statistically significant decrease in E. coli resistance to amoxicillin-clavulanic acid (APC: -5.85; C.I. 95% p < 0.05) and a statistically significant increase in K. pneumoniae resistance to 3GC (APC: 9.93; CI (-19.9-14.4 95% p < 0.05). There were no statistically significant differences in AMR incidence pre- and post-COVID-19. Conclusion: The COVID-19 pandemic did not appear to influence the AMR incidence in our urology department. However, the overall prevalence of AMR and MDROs in our department remains high compared to European AMR.

Published
2023

30. USO DEGLI ANTIBIOTICI NEL FINE VITA.

Author

Moroni, Matteo, Melo, Massimo, Antonione, Raffaella, Fantoni, Massimo, Luzzati, Roberto, Lanzafame, Massimiliano, Murri, Rita, Gilioli, Fabio, Dentali, Francesco, Manfellotto, Dario, Fraccaro, Biancamaria, and Patil, Luigi

Published
2024

31. Prevalence and Antimicrobial Resistance Patterns of Hospital Acquired Infections through the COVID-19 Pandemic: Real-Word Data from a Tertiary Urological Centre

Author

Gavi, Filippo, primary, Fiori, Barbara, additional, Gandi, Carlo, additional, Campetella, Marco, additional, Bientinesi, Riccardo, additional, Marino, Filippo, additional, Fettucciari, Daniele, additional, Rossi, Francesco, additional, Moretto, Stefano, additional, Murri, Rita, additional, Pierconti, Francesco, additional, Racioppi, Marco, additional, and Sacco, Emilio, additional

Published
2023
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32. Epidemiology, time course, and risk factors for hospital-acquired bloodstream infections in a cohort of 14,884 patients before and during the COVID-19 pandemic

Author

Taddei, Eleonora, primary, Pafundi, Pia Clara, additional, Masciocchi, Carlotta, additional, Fiori, Barbara, additional, Segala, Francesco Vladimiro, additional, Antenucci, Laura, additional, Guerriero, Silvia, additional, Pastorino, Roberta, additional, Scarsi, Nicolò, additional, Damiani, Andrea, additional, Sanguinetti, Maurizio, additional, De Pascale, Gennaro, additional, Fantoni, Massimo, additional, Murri, Rita, additional, and De Angelis, Giulia, additional

Published
2023
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34. Cefiderocol-containing regimens for the treatment of carbapenem-resistant A. baumannii ventilator-associated pneumonia: a propensity-weighted cohort study

Author

Rando, Emanuele, primary, Cutuli, Salvatore Lucio, additional, Sangiorgi, Flavio, additional, Tanzarella, Eloisa Sofia, additional, Giovannenze, Francesca, additional, De Angelis, Giulia, additional, Murri, Rita, additional, Antonelli, Massimo, additional, Fantoni, Massimo, additional, and De Pascale, Gennaro, additional

Published
2023
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36. A proposal for a comprehensive approach to infections across the surgical pathway

Author

Sartelli, Massimo, Pagani, Leonardo, Iannazzo, Stefania, Moro, Maria Luisa, Viale, Pierluigi, Pan, Angelo, Ansaloni, Luca, Coccolini, Federico, D’Errico, Marcello Mario, Agreiter, Iris, Amadio Nespola, Giorgio, Barchiesi, Francesco, Benigni, Valeria, Binazzi, Raffaella, Cappanera, Stefano, Chiodera, Alessandro, Cola, Valentina, Corsi, Daniela, Cortese, Francesco, Crapis, Massimo, Cristini, Francesco, D’Arpino, Alessandro, De Simone, Belinda, Di Bella, Stefano, Di Marzo, Francesco, Donati, Abele, Elisei, Daniele, Fantoni, Massimo, Ferrari, Anna, Foghetti, Domitilla, Francisci, Daniela, Gattuso, Gianni, Giacometti, Andrea, Gesuelli, Guido Cesare, Marmorale, Cristina, Martini, Enrica, Meledandri, Marcello, Murri, Rita, Padrini, Daniela, Palmieri, Dalia, Pauri, Paola, Rebagliati, Carla, Ricchizzi, Enrico, Sambri, Vittorio, Schimizzi, Anna Maria, Siquini, Walter, Scoccia, Loredana, Scoppettuolo, Giancarlo, Sganga, Gabriele, Storti, Nadia, Tavio, Marcello, Toccafondi, Giulio, Tumietto, Fabio, Viaggi, Bruno, Vivarelli, Marco, Tranà, Cristian, Raso, Melina, Labricciosa, Francesco Maria, Dhingra, Sameer, and Catena, Fausto

Published
2020
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37. Antibiotic prophylaxis in urologic interventions: Who, when, where?

Author

Marino, Filippo, Rossi, Francesco, Murri, Rita, and Sacco, Emilio

Subjects
ANTIBIOTIC prophylaxis, ENDOSCOPIC surgery, PERCUTANEOUS nephrolithotomy, EXTRACORPOREAL shock wave lithotripsy, EVIDENCE gaps, PROSTATE biopsy, SURGICAL complications, BLADDER cancer
Abstract

Background: Periprocedural prophylaxis in medicine encompasses the set of measures (physical, chemical, and pharmacological) used to reduce the risk of infection. Antibiotic prophylaxis (AP) refers to the administration of a short-term regimen of antibiotics shortly before a medical procedure to reduce the risk of infectious complications that can result from diagnostic and therapeutic interventions. The outspreading growth of multidrug-resistant bacterial species and changes in the bacterial local ecosystem have impeded the development of a unique scheme of AP in urology. Objectives: To review the literature and current guidelines regarding AP for urological diagnostic and therapeutic procedures, and to define agents, timing, and occasions when administering pharmacological prophylaxis. Secondly, according to current literature, to open new scenarios where AP can be useful or useless. Results: Major gaps in evidence still exist in this field. AP appears useful in many invasive procedures and some sub-populations at risk of infectious complications. AP is not routinely recommended for urodynamic exams, diagnostic cystoscopy, and extracorporeal shock-wave lithotripsy. The available data regarding the use of AP during the transperineal prostate biopsy are still unclear; conversely, in the case of the transrectal approach AP is mandatory. AP is still considered the gold standard for the prevention of postoperative infective complications in the case of ureteroscopy, percutaneous nephrolithotomy, endoscopic resection of bladder tumor, endoscopic resection of the prostate, and prosthetic or major surgery. Conclusion: The review highlights the complexity of determining the appropriate candidates for AP, emphasizing the importance of considering patient-specific factors such as comorbidities, immunocompetence, and the nature of the urologic intervention. The evidence suggests that a one-size-fits-all approach may not be suitable, and a tailored strategy based on the specific procedure and patient characteristics is essential. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Machine Learning and Antibiotic Management

Author

Maviglia, Riccardo, Michi, Teresa, Passaro, Davide, Raggi, Valeria, Bocci, Maria Grazia, Piervincenzi, Edoardo, Mercurio, Giovanna, Lucente, Monica Christine, Murri, Rita, Lucente, Monica, Murri, Rita (ORCID:0000-0003-4263-7854), Maviglia, Riccardo, Michi, Teresa, Passaro, Davide, Raggi, Valeria, Bocci, Maria Grazia, Piervincenzi, Edoardo, Mercurio, Giovanna, Lucente, Monica Christine, Murri, Rita, Lucente, Monica, and Murri, Rita (ORCID:0000-0003-4263-7854)

Abstract

Machine learning and cluster analysis applied to the clinical setting of an intensive care unit can be a valuable aid for clinical management, especially with the increasing complexity of clinical monitoring. Providing a method to measure clinical experience, a proxy for that automatic gestalt evaluation that an experienced clinician sometimes effortlessly, but often only after long, hard consideration and consultation with colleagues, relies upon for decision making, is what we wanted to achieve with the application of machine learning to antibiotic therapy and clinical monitoring in the present work. This is a single-center retrospective analysis proposing methods for evaluation of vitals and antimicrobial therapy in intensive care patients. For each patient included in the present study, duration of antibiotic therapy, consecutive days of treatment and type and combination of antimicrobial agents have been assessed and considered as single unique daily record for analysis. Each parameter, composing a record was normalized using a fuzzy logic approach and assigned to five descriptive categories (fuzzy domain sub-sets ranging from "very low" to "very high"). Clustering of these normalized therapy records was performed, and each patient/day was considered to be a pertaining cluster. The same methodology was used for hourly bed-side monitoring. Changes in patient conditions (monitoring) can lead to a shift of clusters. This can provide an additional tool for assessing progress of complex patients. We used Fuzzy logic normalization to descriptive categories of parameters as a form nearer to human language than raw numbers.

Published
2022

39. Myocardial Injury Portends a Higher Risk of Mortality and Long-Term Cardiovascular Sequelae after Hospital Discharge in COVID-19 Survivors

Author

Rinaldi, Riccardo, Basile, Mattia, Salzillo, Carmine, Grieco, Domenico Luca, Caffè, Andrea, Masciocchi, Carlotta, Lilli, Livia, Damiani, Andrea, La Vecchia, Giulia, Iannaccone, Giulia, Bonanni, Alice, De Pascale, Gennaro, Murri, Rita, Fantoni, Massimo, Liuzzo, Giovanna, Sanna, Tommaso, Massetti, Massimo, Gasbarrini, Antonio, Valentini, Vincenzo, Antonelli, Massimo, Crea, Filippo, Montone, Rocco Antonio, On Behalf Of The Gemelli Against Covid Group, Null, De Pascale, Gennaro (ORCID:0000-0002-8255-0676), Murri, Rita (ORCID:0000-0003-4263-7854), Fantoni, Massimo (ORCID:0000-0001-6913-8460), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Sanna, Tommaso (ORCID:0000-0002-5760-6885), Massetti, Massimo (ORCID:0000-0002-7100-8478), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Valentini, Vincenzo (ORCID:0000-0003-4637-6487), Antonelli, Massimo (ORCID:0000-0003-3007-1670), Crea, Filippo (ORCID:0000-0001-9404-8846), Rinaldi, Riccardo, Basile, Mattia, Salzillo, Carmine, Grieco, Domenico Luca, Caffè, Andrea, Masciocchi, Carlotta, Lilli, Livia, Damiani, Andrea, La Vecchia, Giulia, Iannaccone, Giulia, Bonanni, Alice, De Pascale, Gennaro, Murri, Rita, Fantoni, Massimo, Liuzzo, Giovanna, Sanna, Tommaso, Massetti, Massimo, Gasbarrini, Antonio, Valentini, Vincenzo, Antonelli, Massimo, Crea, Filippo, Montone, Rocco Antonio, On Behalf Of The Gemelli Against Covid Group, Null, De Pascale, Gennaro (ORCID:0000-0002-8255-0676), Murri, Rita (ORCID:0000-0003-4263-7854), Fantoni, Massimo (ORCID:0000-0001-6913-8460), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Sanna, Tommaso (ORCID:0000-0002-5760-6885), Massetti, Massimo (ORCID:0000-0002-7100-8478), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Valentini, Vincenzo (ORCID:0000-0003-4637-6487), Antonelli, Massimo (ORCID:0000-0003-3007-1670), and Crea, Filippo (ORCID:0000-0001-9404-8846)

Abstract

Background: Cardiovascular sequelae after COVID-19 are frequent. However, the predictors for their occurrence are still unknown. In this study, we aimed to assess whether myocardial injury during COVID-19 hospitalization is associated to CV sequelae and death after hospital discharge. Methods: In this prospective observational study, consecutive patients who were admitted for COVID-19 in a metropolitan COVID-19 hub in Italy, between March 2021 and January 2022, with a >= 1 assessment of high sensitivity cardiac troponin I (hs-cTnI) were included in the study, if they were alive at hospital discharge. Myocardial injury was defined as elevation hs-cTnI > 99th percentile of the upper reference limit. The incidence of all-cause mortality and major adverse cardiovascular and cerebrovascular events (MACCE, including cardiovascular death, admission for acute or chronic coronary syndrome, hospitalization for heart failure, and stroke/transient ischemic attack) at follow-up were the primary outcomes. Arrhythmias, inflammatory heart diseases, and/or thrombotic disorders were analyzed as well. Results: Among the 701 COVID-19 survivors (mean age 66.4 +/- 14.4 years, 40.2% female), myocardial injury occurred in 75 (10.7%) patients. At a median follow-up of 270 days (IQR 165, 380), all-cause mortality (21.3% vs. 6.1%, p < 0.001), MACCE (25.3% vs. 4.5%, p < 0.001), arrhythmias (9.3% vs. 5.0%, p = 0.034), and inflammatory heart disease (8.0% vs. 1.1%, p < 0.001) were more frequent in patients with myocardial injury compared to those without. At multivariate analysis, myocardial injury (HR 1.95 [95% CI:1.05-3.61]), age (HR 1.09 [95% CI:1.06-1.12]), and chronic kidney disease (HR 2.63 [95% CI:1.33-5.21]) were independent predictors of death. Myocardial injury (HR 3.92 [95% CI:2.07-7.42]), age (HR 1.05 [95% CI:1.02-1.08]), and diabetes (HR 2.35 [95% CI:1.25-4.43]) were independent predictors of MACCE. Conclusion: In COVID-19 survivors, myocardial injury during the hospi

Published
2022

40. Effect of Lockdowns on Hospital Staff in a COVID Center: A Retrospective Observational Study

Author

Vetrugno, Giuseppe, Sanguinetti, Maurizio, Murri, Rita, Sali, Michela, Marchetti, Simona, Santangelo, Rosaria, Fantoni, Massimo, Cingolani, Antonella, Scoppettuolo, Giancarlo, Di Donato, Michele, Grassi, Vincenzo M, Foti, Federica, Marchese, Luca, De Giorgio, Fabio, Oliva, Antonio, Staiti, Domenico, De Simone, Francesco Maria, Pascucci, Domenico, Cascini, Fidelia, Pastorino, Roberta, Pires Marafon, Denise, Cambieri, Andrea, Laurenti, Patrizia, Boccia, Stefania, Ricciardi, Walter, Franceschi, Francesco, On Behalf Of Gemelli-Against-Covid, Null, Vetrugno, Giuseppe (ORCID:0000-0003-0181-2855), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Murri, Rita (ORCID:0000-0003-4263-7854), Sali, Michela (ORCID:0000-0003-3609-2990), Santangelo, Rosaria (ORCID:0000-0002-8056-218X), Fantoni, Massimo (ORCID:0000-0001-6913-8460), Cingolani, Antonella (ORCID:0000-0002-3793-2755), De-Giorgio, Fabio (ORCID:0000-0002-9447-9707), Oliva, Antonio (ORCID:0000-0001-7120-616X), Staiti, Domenico (ORCID:0000-0001-5179-9690), Pascucci, Domenico (ORCID:0000-0002-5804-2284), Cascini, Fidelia (ORCID:0000-0001-6499-0734), Pastorino, Roberta (ORCID:0000-0001-5013-0733), Pires-Marafon, Denise, Laurenti, Patrizia (ORCID:0000-0002-8532-0593), Boccia, Stefania (ORCID:0000-0002-1864-749X), Ricciardi, Walter (ORCID:0000-0002-5655-688X), Franceschi, Francesco (ORCID:0000-0001-6266-445X), Vetrugno, Giuseppe, Sanguinetti, Maurizio, Murri, Rita, Sali, Michela, Marchetti, Simona, Santangelo, Rosaria, Fantoni, Massimo, Cingolani, Antonella, Scoppettuolo, Giancarlo, Di Donato, Michele, Grassi, Vincenzo M, Foti, Federica, Marchese, Luca, De Giorgio, Fabio, Oliva, Antonio, Staiti, Domenico, De Simone, Francesco Maria, Pascucci, Domenico, Cascini, Fidelia, Pastorino, Roberta, Pires Marafon, Denise, Cambieri, Andrea, Laurenti, Patrizia, Boccia, Stefania, Ricciardi, Walter, Franceschi, Francesco, On Behalf Of Gemelli-Against-Covid, Null, Vetrugno, Giuseppe (ORCID:0000-0003-0181-2855), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Murri, Rita (ORCID:0000-0003-4263-7854), Sali, Michela (ORCID:0000-0003-3609-2990), Santangelo, Rosaria (ORCID:0000-0002-8056-218X), Fantoni, Massimo (ORCID:0000-0001-6913-8460), Cingolani, Antonella (ORCID:0000-0002-3793-2755), De-Giorgio, Fabio (ORCID:0000-0002-9447-9707), Oliva, Antonio (ORCID:0000-0001-7120-616X), Staiti, Domenico (ORCID:0000-0001-5179-9690), Pascucci, Domenico (ORCID:0000-0002-5804-2284), Cascini, Fidelia (ORCID:0000-0001-6499-0734), Pastorino, Roberta (ORCID:0000-0001-5013-0733), Pires-Marafon, Denise, Laurenti, Patrizia (ORCID:0000-0002-8532-0593), Boccia, Stefania (ORCID:0000-0002-1864-749X), Ricciardi, Walter (ORCID:0000-0002-5655-688X), and Franceschi, Francesco (ORCID:0000-0001-6266-445X)

Abstract

At the onset of the SARS-CoV-2 pandemic, individual and social measures were strengthened through restrictive non-pharmaceutical interventions, labelled with the term "lockdown". In Italy, there were two lockdowns (9 March 2020-3 May 2020 and 3 November 2020-27 March 2021). As part of preventive measures, healthcare workers and the administrative staff population of Policlinico A. Gemelli underwent nasopharyngeal swab tests from 1 March 2020 to 9 February 2022, a long time interval that includes the two aforementioned lockdowns. The population included 8958 people from 1 March 2020 to 31 December 2020; 8981 people from 1 January 2021 to 31 December 2021; and 8981 people from 1 January 2022 to 9 February 2022. We then analysed pseudo-anonymized data, using a retrospective observational approach to evaluate the impact of the lockdown on the incidence of SARS-CoV-2 infections within the population. Given the 14 day contagious period, the swab positivity rate (SPR) among the staff decreased significantly at the end of the first lockdown, every day prior to 18 May 2020, by 0.093 (p < 0.0001, CI = (-0.138--0.047)). After the fourteenth day post the end of the first lockdown (18 May 2020), the SPR increased daily at a rate of 0.024 (p < 0.0001, 95% CI = (0.013-0.034)). In addition, the SPR appeared to increase significantly every day prior to 17 November 2020 by 0.024 (p < 0.0001, CI = (0.013-0.034)). After the fourteenth day post the start of the second lockdown (17 November 2020), the SPR decreased daily at a rate of 0.039 (p < 0.0001, 95% CI = (-0.050--0.027)). These data demonstrate that, in our Institution, the lockdowns helped to both protect healthcare workers and maintain adequate standards of care for COVID and non-COVID patients for the duration of the state of emergency in Italy.

Published
2022

41. COVID-19 atypical Parsonage-Turner syndrome: a case report

Author

Zazzara, Maria Beatrice, Modoni, Anna, Bizzarro, Alessandra, Lauria, Alessandra, Ciciarello, Francesca, Pais, Cristina, Galluzzo, Vincenzo, Landi, Francesco, Tostato, Matteo, Gremese, Elisa, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Settanni, Carlo Romano, Porcari, Serena, Benvenuto, Francesca, Bramato, Giulia, Brandi, Vincenzo, Carfì, Angelo, Lo Monaco, Maria Rita, Martone, Anna Maria, Marzetti, Emanuele, Napolitano, Carmen, Pagano, Francesco Cosimo, Rocchi, Sara, Rota, Elisabetta, Salerno, Andrea Maria, Tosato, Matteo, Tritto, Marcello, Calvani, Riccardo, Catalano, Lucio, Picca, Anna, Savera, Giulia, Cauda, Roberto, Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, Eleonora, Moschese, Davide, Ciccullo, Arturo, Stella, Leonardo, Addolorato, Giovanni, Franceschi, Francesco, Mingrone, Gertrude, Zocco, Maria Assunta, Sanguinetti, Maurizio, Cattani Franchi, Paola, Marchetti, Simona, Posteraro, Brunella, Sali, Michela, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, Gloria, Cozzupoli, Maria Grazia, Culiersi, Carola, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, Crudo, Fabrizio, Di Cintio, Giovanni, Longobardi, Ylenia, Tricarico, Laura, Santantonio, Mariaconsiglia, Di Cesare, Tiziana, Guarino, Mariateresa, Corbò, Marco, Settimi, Stefano, Mele, Dario Antonio, Brigato, Francesca, Buonsenso, Danilo, Valentini, Piero, Sinatti, Dario, De Rose, Gabriella, Richeldi, Luca, Lombardi, Francesco, Calabrese, Angelo, Varone, Francesco, Leone, Paolo Maria, Siciliano, Matteo, Corbo, Giuseppe Maria, Montemurro, Giuliano, Calvello, Mariarosaria, Intini, Enrica, Simonetti, Jacopo, Pasciuto, Giuliana, Adiletta, Veronica, Sofia, Carmelo, Licata, Maria Angela Vittoria Anna Chiara, Sani, Gabriele, Janiri, Delfina, Simonetti, Alessio, Modica, Marco, Montanari, Silvia, Catinari, Antonello, Terenzi, Beatrice, Natale, Luigi, Larici, Anna Rita, Marano, Riccardo, Pirronti, Tommaso, Infante, Amato, Paglionico, Annamaria, Petricca, Luca, Tolusso, Barbara, Alivernini, Stefano, Di Mario, Clara, Santoliquido, Angelo, Santoro, Luca, Nesci, Antonio, Di Giorgio, Angela, Null, Null, Landi, Francesco (ORCID:0000-0002-3472-1389), Gremese, Elisa (ORCID:0000-0002-2248-1058), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Fantoni, Massimo (ORCID:0000-0001-6913-8460), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Marzetti, Emanuele (ORCID:0000-0001-9567-6983), Pagano, Francesco, Salerno, Andrea, Calvani, Riccardo (ORCID:0000-0001-5472-2365), Cauda, Roberto (ORCID:0000-0002-1498-4229), Murri, Rita (ORCID:0000-0003-4263-7854), Cingolani, Antonella (ORCID:0000-0002-3793-2755), Ventura, Giulio (ORCID:0000-0002-0304-7264), Addolorato, Giovanni (ORCID:0000-0002-1522-9946), Zocco, Maria Assunta (ORCID:0000-0002-0814-9542), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Cattani, Paola (ORCID:0000-0003-4678-4763), Posteraro, Brunella (ORCID:0000-0002-1663-7546), Sali, Michela (ORCID:0000-0003-3609-2990), Rizzo, Stanislao (ORCID:0000-0001-6302-063X), Savastano, Maria Cristina (ORCID:0000-0003-1397-4333), Passali, Giulio Cesare (ORCID:0000-0002-8176-0962), Paludetti, Gaetano (ORCID:0000-0003-2480-1243), Galli, Jacopo (ORCID:0000-0001-6353-6249), Settimi, Stefano (ORCID:0000-0003-0104-1501), Mele, Dario, Valentini, Piero (ORCID:0000-0001-6095-9510), Richeldi, Luca (ORCID:0000-0001-8594-1448), Corbo, Giuseppe Maria (ORCID:0000-0002-8104-4659), Licata, Maria Angela, Sani, Gabriele (ORCID:0000-0002-9767-8752), Natale, Luigi (ORCID:0000-0002-7949-5119), Larici, Anna Rita (ORCID:0000-0002-1882-6244), Marano, Riccardo (ORCID:0000-0003-2710-2093), Pirronti, Tommaso (ORCID:0000-0003-3138-4097), Tolusso, Barbara (ORCID:0000-0002-9108-6609), Alivernini, Stefano (ORCID:0000-0002-7383-4212), Santoliquido, Angelo (ORCID:0000-0003-1539-4017), Zazzara, Maria Beatrice, Modoni, Anna, Bizzarro, Alessandra, Lauria, Alessandra, Ciciarello, Francesca, Pais, Cristina, Galluzzo, Vincenzo, Landi, Francesco, Tostato, Matteo, Gremese, Elisa, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Settanni, Carlo Romano, Porcari, Serena, Benvenuto, Francesca, Bramato, Giulia, Brandi, Vincenzo, Carfì, Angelo, Lo Monaco, Maria Rita, Martone, Anna Maria, Marzetti, Emanuele, Napolitano, Carmen, Pagano, Francesco Cosimo, Rocchi, Sara, Rota, Elisabetta, Salerno, Andrea Maria, Tosato, Matteo, Tritto, Marcello, Calvani, Riccardo, Catalano, Lucio, Picca, Anna, Savera, Giulia, Cauda, Roberto, Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, Eleonora, Moschese, Davide, Ciccullo, Arturo, Stella, Leonardo, Addolorato, Giovanni, Franceschi, Francesco, Mingrone, Gertrude, Zocco, Maria Assunta, Sanguinetti, Maurizio, Cattani Franchi, Paola, Marchetti, Simona, Posteraro, Brunella, Sali, Michela, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, Gloria, Cozzupoli, Maria Grazia, Culiersi, Carola, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, Crudo, Fabrizio, Di Cintio, Giovanni, Longobardi, Ylenia, Tricarico, Laura, Santantonio, Mariaconsiglia, Di Cesare, Tiziana, Guarino, Mariateresa, Corbò, Marco, Settimi, Stefano, Mele, Dario Antonio, Brigato, Francesca, Buonsenso, Danilo, Valentini, Piero, Sinatti, Dario, De Rose, Gabriella, Richeldi, Luca, Lombardi, Francesco, Calabrese, Angelo, Varone, Francesco, Leone, Paolo Maria, Siciliano, Matteo, Corbo, Giuseppe Maria, Montemurro, Giuliano, Calvello, Mariarosaria, Intini, Enrica, Simonetti, Jacopo, Pasciuto, Giuliana, Adiletta, Veronica, Sofia, Carmelo, Licata, Maria Angela Vittoria Anna Chiara, Sani, Gabriele, Janiri, Delfina, Simonetti, Alessio, Modica, Marco, Montanari, Silvia, Catinari, Antonello, Terenzi, Beatrice, Natale, Luigi, Larici, Anna Rita, Marano, Riccardo, Pirronti, Tommaso, Infante, Amato, Paglionico, Annamaria, Petricca, Luca, Tolusso, Barbara, Alivernini, Stefano, Di Mario, Clara, Santoliquido, Angelo, Santoro, Luca, Nesci, Antonio, Di Giorgio, Angela, Null, Null, Landi, Francesco (ORCID:0000-0002-3472-1389), Gremese, Elisa (ORCID:0000-0002-2248-1058), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Fantoni, Massimo (ORCID:0000-0001-6913-8460), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Marzetti, Emanuele (ORCID:0000-0001-9567-6983), Pagano, Francesco, Salerno, Andrea, Calvani, Riccardo (ORCID:0000-0001-5472-2365), Cauda, Roberto (ORCID:0000-0002-1498-4229), Murri, Rita (ORCID:0000-0003-4263-7854), Cingolani, Antonella (ORCID:0000-0002-3793-2755), Ventura, Giulio (ORCID:0000-0002-0304-7264), Addolorato, Giovanni (ORCID:0000-0002-1522-9946), Zocco, Maria Assunta (ORCID:0000-0002-0814-9542), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Cattani, Paola (ORCID:0000-0003-4678-4763), Posteraro, Brunella (ORCID:0000-0002-1663-7546), Sali, Michela (ORCID:0000-0003-3609-2990), Rizzo, Stanislao (ORCID:0000-0001-6302-063X), Savastano, Maria Cristina (ORCID:0000-0003-1397-4333), Passali, Giulio Cesare (ORCID:0000-0002-8176-0962), Paludetti, Gaetano (ORCID:0000-0003-2480-1243), Galli, Jacopo (ORCID:0000-0001-6353-6249), Settimi, Stefano (ORCID:0000-0003-0104-1501), Mele, Dario, Valentini, Piero (ORCID:0000-0001-6095-9510), Richeldi, Luca (ORCID:0000-0001-8594-1448), Corbo, Giuseppe Maria (ORCID:0000-0002-8104-4659), Licata, Maria Angela, Sani, Gabriele (ORCID:0000-0002-9767-8752), Natale, Luigi (ORCID:0000-0002-7949-5119), Larici, Anna Rita (ORCID:0000-0002-1882-6244), Marano, Riccardo (ORCID:0000-0003-2710-2093), Pirronti, Tommaso (ORCID:0000-0003-3138-4097), Tolusso, Barbara (ORCID:0000-0002-9108-6609), Alivernini, Stefano (ORCID:0000-0002-7383-4212), and Santoliquido, Angelo (ORCID:0000-0003-1539-4017)

Abstract

Background Neurological manifestations of Sars-CoV-2 infection have been described since March 2020 and include both central and peripheral nervous system manifestations. Neurological symptoms, such as headache or persistent loss of smell and taste, have also been documented in COVID-19 long-haulers. Moreover, long lasting fatigue, mild cognitive impairment and sleep disorders appear to be frequent long term neurological manifestations after hospitalization due to COVID-19. Less is known in relation to peripheral nerve injury related to Sars-CoV-2 infection. Case presentation We report the case of a 47-year-old female presenting with a unilateral chest pain radiating to the left arm lasting for more than two months after recovery from Sars-CoV-2 infection. After referral to our post-acute outpatient service for COVID-19 long haulers, she was diagnosed with a unilateral, atypical, pure sensory brachial plexus neuritis potentially related to COVID-19, which occurred during the acute phase of a mild Sars-CoV-2 infection and persisted for months after resolution of the infection. Conclusions We presented a case of atypical Parsonage-Turner syndrome potentially triggered by Sars-CoV-2 infection, with symptoms and repercussion lasting after viral clearance. A direct involvement of the virus remains uncertain, and the physiopathology is unclear. The treatment of COVID-19 and its long-term consequences represents a relatively new challenge for clinicians and health care providers. A multidisciplinary approach to following-up COVID-19 survivors is strongly advised.

Published
2022

42. Cutaneous diphtheria most likely due to exposure in a detention camp in Libya

Author

Taccari, Francesco, primary, Frondizi, Federico, additional, Salvati, Federica, additional, Giovannenze, Francesca, additional, Del Giacomo, Paola, additional, Damiano, Fernando, additional, Spanu, Teresa, additional, Graffeo, Rosalia, additional, Menchinelli, Giulia, additional, Mariotti, Melinda, additional, Sanguinetti, Maurizio, additional, Castri, Federica, additional, Neumayr, Andreas, additional, Brunetti, Enrico, additional, Errico, Giulia, additional, Murri, Rita, additional, Cauda, Roberto, additional, and Scoppettuolo, Giancarlo, additional

Published
2023
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44. A New Clinical Prediction Rule for Infective Endocarditis in Emergency Department Patients With Fever: Definition and First Validation of the CREED Score

Author

Covino, Marcello, primary, De Vita, Antonio, additional, d'Aiello, Alessia, additional, Ravenna, Salvatore Emanuele, additional, Ruggio, Aureliano, additional, Genuardi, Lorenzo, additional, Simeoni, Benedetta, additional, Piccioni, Andrea, additional, De Matteis, Giuseppe, additional, Murri, Rita, additional, Leone, Antonio Maria, additional, Flex, Andrea, additional, Gasbarrini, Antonio, additional, Liuzzo, Giovanna, additional, Massetti, Massimo, additional, and Franceschi, Francesco, additional

Published
2023
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45. Anakinra in hospitalized COVID-19 patients guided by baseline soluble urokinase plasminogen receptor plasma levels: A real world, retrospective cohort study

Author

Segala, Francesco Vladimiro, primary, Rando, Emanuele, additional, Salvati, Federica, additional, Negri, Marcantonio, additional, Catania, Francesca, additional, Sanmartin, Flavia, additional, Murri, Rita, additional, Giamarellos-Bourboulis, Evangelos J., additional, and Fantoni, Massimo, additional

Published
2023
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47. Sarilumab plus standard of care vs standard of care for the treatment of severe COVID-19: a phase 3, randomized, open-labeled, multi-center study (ESCAPE study)

Author

Mastrorosa, Ilaria, primary, Gagliardini, Roberta, additional, Segala, Francesco Vladimiro, additional, Mondi, Annalisa, additional, Lorenzini, Patrizia, additional, Cerva, Carlotta, additional, Taddei, Eleonora, additional, Bai, Francesca, additional, Vergori, Alessandra, additional, Negri, Marcantonio, additional, Pinnetti, Carmela, additional, Cicalini, Stefania, additional, Murri, Rita, additional, Mazzotta, Valentina, additional, Camici, Marta, additional, Mosti, Silvia, additional, Bini, Teresa, additional, Maffongelli, Gaetano, additional, Beccacece, Alessia, additional, Milozzi, Eugenia, additional, Iannetta, Marco, additional, Lamonica, Silvia, additional, Fusto, Marisa, additional, Plazzi, Maria Maddalena, additional, Ottou, Sandrine, additional, Lichtner, Miriam, additional, Fantoni, Massimo, additional, Andreoni, Massimo, additional, Sarmati, Loredana, additional, Cauda, Roberto, additional, Girardi, Enrico, additional, Nicastri, Emanuele, additional, D'Arminio Monforte, Antonella, additional, Palmieri, Fabrizio, additional, Cingolani, Antonella, additional, Vaia, Francesco, additional, Antinori, Andrea, additional, Agrati, Chiara, additional, Barreca, Filippo, additional, Bertuccio, Maria Paola, additional, Boumis, Evangelo, additional, D'Urso, Angela, additional, De Masi, Margherita, additional, De Zottis, Federico, additional, Del Borgo, Cosmo, additional, Di Gennaro, Francesco, additional, Emiliozzi, Arianna, additional, Fondaco, Laura, additional, Giovannenze, Francesca, additional, Grilli, Elisabetta, additional, Iodice, Daniele, additional, Masone, Erminia, additional, Massa, Barbara, additional, Mastrorosa, Ilaria, additional, Mencarini, Paola, additional, Oliva, Gian Piero, additional, Onnelli, Giovanna, additional, Pace, Pier Giorgio, additional, Paulicelli, Jessica, additional, Sorace, Chiara, additional, and Vitale, Pietro, additional

Published
2023
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48. Malnutrition in COVID-19 survivors: prevalence and risk factors

Author

Tosato, Matteo, Calvani, Riccardo, Ciciarello, Francesca, Galluzzo, Vincenzo, Martone, Anna Maria, Zazzara, Maria Beatrice, Pais, Cristina, Savera, Giulia, Camprubi Robles, Maria, Ramirez, Maria, Landi, Francesco, Gremese, Elisa, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Romano Settanni, Carlo, Porcari, Serena, Benvenuto, Francesca, Bramato, Giulia, Brandi, Vincenzo, Carfì, Angelo, Rita Lo Monaco, Maria, Maria Martone, Anna, Marzetti, Emanuele, Napolitano, Carmen, Pagano, Francesco, Rocchi, Sara, Rota, Elisabetta, Salerno, Andrea, Tritto, Marcello, Beatrice Zazzara, Maria, Catalano, Lucio, Picca, Anna, D’Elia, Mariaelena, Biscotti, Damiano, Cauda, Roberto, Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, Eleonora, Moschese, Davide, Ciccullo, Arturo, Stella, Leonardo, Addolorato, Giovanni, Franceschi, Francesco, Mingrone, Gertrude, Assunta Zocco, Maria, Sanguinetti, Maurizio, Cattani Franchi, Paola, Marchetti, Simona, Posteraro, Brunella, Sali, Michela, Bizzarro, Alessandra, Lauria, Alessandra, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, Gloria, Maria Cozzupoli, Grazia, Culiersi, Carola, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, Crudo, Fabrizio, Di Cintio, Giovanni, Longobardi, Ylenia, Tricarico, Laura, Santantonio, Mariaconsiglia, Di Cesare, Tiziana, Guarino, Mariateresa, Corbò, Marco, Settimi, Stefano, Mele, Dario, Brigato, Francesca, Buonsenso, Danilo, Valentini, Piero, Sinatti, Dario, De Rose, Gabriella, Richeldi, Luca, Lombardi, Francesco, Calabrese, Angelo, Varone, Francesco, Maria Leone, Paolo, Siciliano, Matteo, Corbo, Giuseppe Maria, Montemurro, Giuliano, Calvello, Mariarosaria, Intini, Enrica, Simonetti, Jacopo, Pasciuto, Giuliana, Adiletta, Veronica, Sofia, Carmelo, Angela Licata, Maria, Sani, Gabriele, Janiri, Delfina, Simonetti, Alessio, Modica, Marco, Silvia, Montanari, Catinari, Antonello, Terenzi, Beatrice, Natale, Luigi, Larici, Anna Rita, Marano, Riccardo, Pirronti, Tommaso, Infante, Amato, Paglionico, Annamaria, Petricca, Luca, Tolusso, Barbara, Alivernini, Stefano, Di Mario, Clara, Santoliquido, Angelo, Santoro, Luca, Nesci, Antonio, Di Giorgio, Angela, D’Alessandro, Alessia, Matteo Tosato, Riccardo Calvani (ORCID:0000-0001-5472-2365), Francesca Ciciarello, Vincenzo Galluzzo, Anna Maria Martone, Maria Beatrice Zazzara, Giulia Savera, Francesco Landi (ORCID:0000-0002-3472-1389), Elisa Gremese (ORCID:0000-0002-2248-1058), Roberto Bernabei (ORCID:0000-0002-9197-004X), Massimo Fantoni (ORCID:0000-0001-6913-8460), Emanuele Marzetti (ORCID:0000-0001-9567-6983), Roberto Cauda (ORCID:0000-0002-1498-4229), Giulio Ventura (ORCID:0000-0002-0304-7264), Giovanni Addolorato (ORCID:0000-0002-1522-9946), Francesco Franceschi (ORCID:0000-0001-6266-445X), Maurizio Sanguinetti (ORCID:0000-0002-9780-7059), Paola Cattani (ORCID:0000-0003-4678-4763), Brunella Posteraro (ORCID:0000-0002-1663-7546), Stanislao Rizzo (ORCID:0000-0001-6302-063X), Maria Cristina Savastano (ORCID:0000-0003-1397-4333), Giulio Cesare Passali (ORCID:0000-0002-8176-0962), Jacopo Galli (ORCID:0000-0001-6353-6249), Piero Valentini (ORCID:0000-0001-6095-9510), Luca Richeldi (ORCID:0000-0001-8594-1448), Giuseppe Maria Corbo (ORCID:0000-0002-8104-4659), Gabriele Sani (ORCID:0000-0002-9767-8752), Luigi Natale (ORCID:0000-0002-7949-5119), Anna Rita Larici (ORCID:0000-0002-1882-6244), Riccardo Marano (ORCID:0000-0003-2710-2093), Stefano Alivernini (ORCID:0000-0002-7383-4212), Angelo Santoliquido (ORCID:0000-0003-1539-4017), Tosato, Matteo, Calvani, Riccardo, Ciciarello, Francesca, Galluzzo, Vincenzo, Martone, Anna Maria, Zazzara, Maria Beatrice, Pais, Cristina, Savera, Giulia, Camprubi Robles, Maria, Ramirez, Maria, Landi, Francesco, Gremese, Elisa, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Romano Settanni, Carlo, Porcari, Serena, Benvenuto, Francesca, Bramato, Giulia, Brandi, Vincenzo, Carfì, Angelo, Rita Lo Monaco, Maria, Maria Martone, Anna, Marzetti, Emanuele, Napolitano, Carmen, Pagano, Francesco, Rocchi, Sara, Rota, Elisabetta, Salerno, Andrea, Tritto, Marcello, Beatrice Zazzara, Maria, Catalano, Lucio, Picca, Anna, D’Elia, Mariaelena, Biscotti, Damiano, Cauda, Roberto, Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, Eleonora, Moschese, Davide, Ciccullo, Arturo, Stella, Leonardo, Addolorato, Giovanni, Franceschi, Francesco, Mingrone, Gertrude, Assunta Zocco, Maria, Sanguinetti, Maurizio, Cattani Franchi, Paola, Marchetti, Simona, Posteraro, Brunella, Sali, Michela, Bizzarro, Alessandra, Lauria, Alessandra, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, Gloria, Maria Cozzupoli, Grazia, Culiersi, Carola, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, Crudo, Fabrizio, Di Cintio, Giovanni, Longobardi, Ylenia, Tricarico, Laura, Santantonio, Mariaconsiglia, Di Cesare, Tiziana, Guarino, Mariateresa, Corbò, Marco, Settimi, Stefano, Mele, Dario, Brigato, Francesca, Buonsenso, Danilo, Valentini, Piero, Sinatti, Dario, De Rose, Gabriella, Richeldi, Luca, Lombardi, Francesco, Calabrese, Angelo, Varone, Francesco, Maria Leone, Paolo, Siciliano, Matteo, Corbo, Giuseppe Maria, Montemurro, Giuliano, Calvello, Mariarosaria, Intini, Enrica, Simonetti, Jacopo, Pasciuto, Giuliana, Adiletta, Veronica, Sofia, Carmelo, Angela Licata, Maria, Sani, Gabriele, Janiri, Delfina, Simonetti, Alessio, Modica, Marco, Silvia, Montanari, Catinari, Antonello, Terenzi, Beatrice, Natale, Luigi, Larici, Anna Rita, Marano, Riccardo, Pirronti, Tommaso, Infante, Amato, Paglionico, Annamaria, Petricca, Luca, Tolusso, Barbara, Alivernini, Stefano, Di Mario, Clara, Santoliquido, Angelo, Santoro, Luca, Nesci, Antonio, Di Giorgio, Angela, D’Alessandro, Alessia, Matteo Tosato, Riccardo Calvani (ORCID:0000-0001-5472-2365), Francesca Ciciarello, Vincenzo Galluzzo, Anna Maria Martone, Maria Beatrice Zazzara, Giulia Savera, Francesco Landi (ORCID:0000-0002-3472-1389), Elisa Gremese (ORCID:0000-0002-2248-1058), Roberto Bernabei (ORCID:0000-0002-9197-004X), Massimo Fantoni (ORCID:0000-0001-6913-8460), Emanuele Marzetti (ORCID:0000-0001-9567-6983), Roberto Cauda (ORCID:0000-0002-1498-4229), Giulio Ventura (ORCID:0000-0002-0304-7264), Giovanni Addolorato (ORCID:0000-0002-1522-9946), Francesco Franceschi (ORCID:0000-0001-6266-445X), Maurizio Sanguinetti (ORCID:0000-0002-9780-7059), Paola Cattani (ORCID:0000-0003-4678-4763), Brunella Posteraro (ORCID:0000-0002-1663-7546), Stanislao Rizzo (ORCID:0000-0001-6302-063X), Maria Cristina Savastano (ORCID:0000-0003-1397-4333), Giulio Cesare Passali (ORCID:0000-0002-8176-0962), Jacopo Galli (ORCID:0000-0001-6353-6249), Piero Valentini (ORCID:0000-0001-6095-9510), Luca Richeldi (ORCID:0000-0001-8594-1448), Giuseppe Maria Corbo (ORCID:0000-0002-8104-4659), Gabriele Sani (ORCID:0000-0002-9767-8752), Luigi Natale (ORCID:0000-0002-7949-5119), Anna Rita Larici (ORCID:0000-0002-1882-6244), Riccardo Marano (ORCID:0000-0003-2710-2093), Stefano Alivernini (ORCID:0000-0002-7383-4212), and Angelo Santoliquido (ORCID:0000-0003-1539-4017)

Abstract

Background: Nutritional status is a critical factor throughout COVID-19 disease course. Malnutrition is associated with poor outcomes in hospitalized COVID-19 patients. Aim: To assess the prevalence of malnutrition and identify its associated factors in COVID-19 survivors. Methods: Study cohort included 1230 COVID-19 survivors aged 18-86 attending a post-COVID-19 outpatient service. Data on clinical parameters, anthropometry, acute COVID-19 symptoms, lifestyle habits were collected through a comprehensive medical assessment. Malnutrition was assessed according to Global Leadership Initiative on Malnutrition (GLIM) criteria. Results: Prevalence of malnutrition was 22% at 4-5 months after acute disease. Participants who were not hospitalized during acute COVID-19 showed a higher frequency of malnutrition compared to those who needed hospitalization (26% versus 19%, p < 0.01). Malnutrition was found in 25% COVID-19 survivors over 65 years of age compared to 21% younger participants (p < 0.01). After multivariable adjustment, the likelihood of being malnourished increased progressively and independently with advancing age (Odds ratio [OR] 1.02; 95% CI 1.01-1.03) and in male participants (OR 5.56; 95% CI 3.53-8.74). Malnutrition was associated with loss of appetite (OR 2.50; 95% CI 1.73-3.62), and dysgeusia (OR 4.05; 95% CI 2.30-7.21) during acute COVID-19. Discussion: In the present investigation we showed that malnutrition was highly prevalent in a large cohort of COVID-19 survivors at 4-5 months from acute illness. Conclusions: Our findings highlight the need to implement comprehensive nutritional assessment and therapy as an integral part of care for COVID-19 patients.

Published
2023

49. EPI-Net One Health reporting guideline for antimicrobial consumption and resistance surveillance data: a Delphi approach

Author

Babu Rajendran, N., Arieti, F., Mena-Benitez, C. A., Galia, L., Tebon, M., Alvarez, J., Gladstone, B. P., Collineau, L., De Angelis, Giulia, Duro, R., Gaze, W., Gopel, S., Kanj, S. S., Kasbohrer, A., Limmathurotsakul, D., Lopez de Abechuco, E., Mazzolini, E., Mutters, N. T., Pezzani, M. D., Presterl, E., Renk, H., Rodriguez-Bano, J., Sandulescu, O., Scali, F., Skov, R., Velavan, T. P., Vuong, C., Tacconelli, Evelina, Adegnika, A. A., Avery, L., Bonten, M., Cassini, A., Chauvin, C., Compri, M., Damborg, P., De Greeff, S., Del Toro, M. D., Filter, M., Franklin, A., Gonzalez-Zorn, B., Grave, K., Hocquet, D., Hoelzle, L. E., Kalanxhi, E., Laxminarayan, R., Leibovici, L., Malhotra-Kumar, S., Mendelson, M., Paul, M., Munoz Madero, C., Murri, Rita, Piddock, L. J. V., Ruesen, C., Sanguinetti, Maurizio, Schilling, T., Schrijver, R., Schwaber, M. J., Scudeller, L., Torumkuney, D., Van Boeckel, T., Vanderhaeghen, W., Voss, A., Wozniak, T., De Angelis G. (ORCID:0000-0002-7087-7399), Tacconelli E. (ORCID:0000-0001-8722-5824), Murri R. (ORCID:0000-0003-4263-7854), Sanguinetti M. (ORCID:0000-0002-9780-7059), Babu Rajendran, N., Arieti, F., Mena-Benitez, C. A., Galia, L., Tebon, M., Alvarez, J., Gladstone, B. P., Collineau, L., De Angelis, Giulia, Duro, R., Gaze, W., Gopel, S., Kanj, S. S., Kasbohrer, A., Limmathurotsakul, D., Lopez de Abechuco, E., Mazzolini, E., Mutters, N. T., Pezzani, M. D., Presterl, E., Renk, H., Rodriguez-Bano, J., Sandulescu, O., Scali, F., Skov, R., Velavan, T. P., Vuong, C., Tacconelli, Evelina, Adegnika, A. A., Avery, L., Bonten, M., Cassini, A., Chauvin, C., Compri, M., Damborg, P., De Greeff, S., Del Toro, M. D., Filter, M., Franklin, A., Gonzalez-Zorn, B., Grave, K., Hocquet, D., Hoelzle, L. E., Kalanxhi, E., Laxminarayan, R., Leibovici, L., Malhotra-Kumar, S., Mendelson, M., Paul, M., Munoz Madero, C., Murri, Rita, Piddock, L. J. V., Ruesen, C., Sanguinetti, Maurizio, Schilling, T., Schrijver, R., Schwaber, M. J., Scudeller, L., Torumkuney, D., Van Boeckel, T., Vanderhaeghen, W., Voss, A., Wozniak, T., De Angelis G. (ORCID:0000-0002-7087-7399), Tacconelli E. (ORCID:0000-0001-8722-5824), Murri R. (ORCID:0000-0003-4263-7854), and Sanguinetti M. (ORCID:0000-0002-9780-7059)

Abstract

Strategic and standardised approaches to analysis and reporting of surveillance data are essential to inform antimicrobial resistance (AMR) mitigation measures, including antibiotic policies. Targeted guidance on linking full-scale AMR and antimicrobial consumption (AMC)/antimicrobial residues (AR) surveillance data from the human, animal, and environmental sectors is currently needed. This paper describes the initiative whereby a multidisciplinary panel of experts (56 from 20 countries—52 high income, 4 upper middle or lower income), representing all three sectors, elaborated proposals for structuring and reporting full-scale AMR and AMC/AR surveillance data across the three sectors. An evidence-supported, modified Delphi approach was adopted to reach consensus among the experts for dissemination frequency, language, and overall structure of reporting; core elements and metrics for AMC/AR data; core elements and metrics for AMR data. The recommendations can support multisectoral national and regional plans on antimicrobials policy to reduce resistance rates applying a One Health approach.

Published
2023

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