Search

Your search keyword '"Murray, Tanda"' showing total 33 results
Start Over Author "Murray, Tanda"
33 results on '"Murray, Tanda"'

1. Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol

Author

Gabriel, Stacey B., Altshuler, David M., Abecasis, Gonçalo R., Allayee, Hooman, Cresci, Sharon, Daly, Mark J., de Bakker, Paul I.W., DePristo, Mark A., Do, Ron, Donnelly, Peter, Farlow, Deborah N., Fennell, Tim, Garimella, Kiran, Hazen, Stanley L., Hu, Youna, Jordan, Daniel M., Jun, Goo, Kathiresan, Sekar, Kang, Hyun Min, Kiezun, Adam, Lettre, Guillaume, Li, Bingshan, Li, Mingyao, Newton-Cheh, Christopher H., Padmanabhan, Sandosh, Peloso, Gina, Pulit, Sara, Rader, Daniel J., Reich, David, Reilly, Muredach P., Rivas, Manuel A., Schwartz, Steve, Scott, Laura, Siscovick, David S., Spertus, John A., Stitziel, Nathaniel O., Stoletzki, Nina, Sunyaev, Shamil R., Voight, Benjamin F., Willer, Cristen J., Rich, Stephen S., Akylbekova, Ermeg, Atwood, Larry D., Ballantyne, Christie M., Barbalic, Maja, Barr, R. Graham, Benjamin, Emelia J., Bis, Joshua, Boerwinkle, Eric, Bowden, Donald W., Brody, Jennifer, Budoff, Matthew, Burke, Greg, Buxbaum, Sarah, Carr, Jeff, Chen, Donna T., Chen, Ida Y., Chen, Wei-Min, Concannon, Pat, Crosby, Jacy, Cupples, L. Adrienne, D’Agostino, Ralph, DeStefano, Anita L., Dreisbach, Albert, Dupuis, Josée, Durda, J. Peter, Ellis, Jaclyn, Folsom, Aaron R., Fornage, Myriam, Fox, Caroline S., Fox, Ervin, Funari, Vincent, Ganesh, Santhi K., Gardin, Julius, Goff, David, Gordon, Ora, Grody, Wayne, Gross, Myron, Guo, Xiuqing, Hall, Ira M., Heard-Costa, Nancy L., Heckbert, Susan R., Heintz, Nicholas, Herrington, David M., Hickson, DeMarc, Huang, Jie, Hwang, Shih-Jen, Jacobs, David R., Jenny, Nancy S., Johnson, Andrew D., Johnson, Craig W., Kawut, Steven, Kronmal, Richard, Kurz, Raluca, Lange, Ethan M., Lange, Leslie A., Larson, Martin G., Lawson, Mark, Lewis, Cora E., Levy, Daniel, Li, Dalin, Lin, Honghuang, Liu, Chunyu, Liu, Jiankang, Liu, Kiang, Liu, Xiaoming, Liu, Yongmei, Longstreth, William T., Loria, Cay, Lumley, Thomas, Lunetta, Kathryn, Mackey, Aaron J., Mackey, Rachel, Manichaikul, Ani, Maxwell, Taylor, McKnight, Barbara, Meigs, James B., Morrison, Alanna C., Musani, Solomon K., Mychaleckyj, Josyf C., Nettleton, Jennifer A., North, Kari, O’Donnell, Christopher J., O’Leary, Daniel, Ong, Frank, Palmas, Walter, Pankow, James S., Pankratz, Nathan D., Paul, Shom, Perez, Marco, Person, Sharina D., Polak, Joseph, Post, Wendy S., Psaty, Bruce M., Quinlan, Aaron R., Raffel, Leslie J., Ramachandran, Vasan S., Reiner, Alexander P., Rice, Kenneth, Rotter, Jerome I., Sanders, Jill P., Schreiner, Pamela, Seshadri, Sudha, Shea, Steve, Sidney, Stephen, Silverstein, Kevin, Smith, Nicholas L., Sotoodehnia, Nona, Srinivasan, Asoke, Taylor, Herman A., Taylor, Kent, Thomas, Fridtjof, Tracy, Russell P., Tsai, Michael Y., Volcik, Kelly A., Wassel, Chrstina L., Watson, Karol, Wei, Gina, White, Wendy, Wiggins, Kerri L., Wilk, Jemma B., Williams, O. Dale, Wilson, Gregory, Wilson, James G., Wolf, Phillip, Zakai, Neil A., Hardy, John, Meschia, James F., Nalls, Michael, Singleton, Andrew, Worrall, Brad, Bamshad, Michael J., Barnes, Kathleen C., Abdulhamid, Ibrahim, Accurso, Frank, Anbar, Ran, Beaty, Terri, Bigham, Abigail, Black, Phillip, Bleecker, Eugene, Buckingham, Kati, Cairns, Anne Marie, Caplan, Daniel, Chatfield, Barbara, Chidekel, Aaron, Cho, Michael, Christiani, David C., Crapo, James D., Crouch, Julia, Daley, Denise, Dang, Anthony, Dang, Hong, De Paula, Alicia, DeCelie-Germana, Joan, Drumm, Allen DozorMitch, Dyson, Maynard, Emerson, Julia, Emond, Mary J., Ferkol, Thomas, Fink, Robert, Foster, Cassandra, Froh, Deborah, Gao, Li, Gershan, William, Gibson, Ronald L., Godwin, Elizabeth, Gondor, Magdalen, Gutierrez, Hector, Hansel, Nadia N., Hassoun, Paul M., Hiatt, Peter, Hokanson, John E., Howenstine, Michelle, Hummer, Laura K., Kanga, Jamshed, Kim, Yoonhee, Knowles, Michael R., Konstan, Michael, Lahiri, Thomas, Laird, Nan, Lange, Christoph, Lin, Lin, Lin, Xihong, Louie, Tin L., Lynch, David, Make, Barry, Martin, Thomas R., Mathai, Steve C., Mathias, Rasika A., McNamara, John, McNamara, Sharon, Meyers, Deborah, Millard, Susan, Mogayzel, Peter, Moss, Richard, Murray, Tanda, Nielson, Dennis, Noyes, Blakeslee, O’Neal, Wanda, Orenstein, David, O’Sullivan, Brian, Pace, Rhonda, Pare, Peter, Parker, H. Worth, Passero, Mary Ann, Perkett, Elizabeth, Prestridge, Adrienne, Rafaels, Nicholas M., Ramsey, Bonnie, Regan, Elizabeth, Ren, Clement, Retsch-Bogart, George, Rock, Michael, Rosen, Antony, Rosenfeld, Margaret, Ruczinski, Ingo, Sanford, Andrew, Schaeffer, David, Sell, Cindy, Sheehan, Daniel, Silverman, Edwin K., Sin, Don, Spencer, Terry, Stonebraker, Jackie, Tabor, Holly K., Varlotta, Laurie, Vergara, Candelaria I., Weiss, Robert, Wigley, Fred, Wise, Robert A., Wright, Fred A., Wurfel, Mark M., Zanni, Robert, Zou, Fei, Nickerson, Deborah A., Rieder, Mark J., Green, Phil, Shendure, Jay, Akey, Joshua M., Bustamante, Carlos D., Crosslin, David R., Eichler, Evan E., Fox, P. Keolu, Fu, Wenqing, Gordon, Adam, Gravel, Simon, Jarvik, Gail P., Johnsen, Jill M., Kan, Mengyuan, Kenny, Eimear E., Kidd, Jeffrey M., Lara-Garduno, Fremiet, Leal, Suzanne M., Liu, Dajiang J., McGee, Sean, O’Connor, Timothy D., Paeper, Bryan, Robertson, Peggy D., Smith, Joshua D., Staples, Jeffrey C., Tennessen, Jacob A., Turner, Emily H., Wang, Gao, Yi, Qian, Jackson, Rebecca, Peters, Ulrike, Carlson, Christopher S., Anderson, Garnet, Anton-Culver, Hoda, Assimes, Themistocles L., Auer, Paul L., Beresford, Shirley, Bizon, Chris, Black, Henry, Brunner, Robert, Brzyski, Robert, Burwen, Dale, Caan, Bette, Carty, Cara L., Chlebowski, Rowan, Cummings, Steven, Curb, J. David, Eaton, Charles B., Ford, Leslie, Franceschini, Nora, Fullerton, Stephanie M., Gass, Margery, Geller, Nancy, Heiss, Gerardo, Howard, Barbara V., Hsu, Li, Hutter, Carolyn M., Ioannidis, John, Jiao, Shuo, Johnson, Karen C., Kooperberg, Charles, Kuller, Lewis, LaCroix, Andrea, Lakshminarayan, Kamakshi, Lane, Dorothy, Lasser, Norman, LeBlanc, Erin, Li, Kuo-Ping, Limacher, Marian, Lin, Dan-Yu, Logsdon, Benjamin A., Ludlam, Shari, Manson, JoAnn E., Margolis, Karen, Martin, Lisa, McGowan, Joan, Monda, Keri L., Kotchen, Jane Morley, Nathan, Lauren, Ockene, Judith, O’Sullivan, Mary Jo, Phillips, Lawrence S., Prentice, Ross L., Robbins, John, Robinson, Jennifer G., Rossouw, Jacques E., Sangi-Haghpeykar, Haleh, Sarto, Gloria E., Shumaker, Sally, Simon, Michael S., Stefanick, Marcia L., Stein, Evan, Tang, Hua, Taylor, Kira C., Thomson, Cynthia A., Thornton, Timothy A., Van Horn, Linda, Vitolins, Mara, Wactawski-Wende, Jean, Wallace, Robert, Wassertheil-Smoller, Sylvia, Zeng, Donglin, Applebaum-Bowden, Deborah, Feolo, Michael, Gan, Weiniu, Paltoo, Dina N., Sholinsky, Phyliss, Sturcke, Anne, Zhang, He, Xue, Chenyi, Schmidt, Ellen M., Tang, Zheng-Zheng, Auer, Paul, Li, Kuo-ping, Flannick, Jason, Zhang, Ji, Fuchsberger, Christian, Gaulton, Kyle, Lindgren, Cecilia, Locke, Adam, Manning, Alisa, Sim, Xueling, Holmen, Oddgeir L., Gottesman, Omri, Lu, Yingchang, Ruderfer, Douglas, Stahl, Eli A., Duan, Qing, Li, Yun, Durda, Peter, Isaacs, Aaron, Hofman, Albert, Bis, Joshua C., Correa, Adolfo, Griswold, Michael E., Jakobsdottir, Johanna, Smith, Albert V., Schreiner, Pamela J., Feitosa, Mary F., Zhang, Qunyuan, Huffman, Jennifer E., Wassel, Christina L., Martin, Lisa W., Rosenthal, Elisabeth A., Tsai, Michael, Fox, Ervin R., Jackson, Rebecca D., van Duijn, Cornelia M., Uitterlinden, André G., Gudnason, Vilmundur, Jr., Borecki, Ingrid B., Hayward, Caroline, Rudan, Igor, Chen, Y. Eugene, Bottinger, Erwin P., Loos, Ruth J.F., Sætrom, Pål, Hveem, Kristian, Boehnke, Michael, Groop, Leif, McCarthy, Mark, Meitinger, Thomas, North, Kari E., Altshuler, David, and Abecasis, Goncalo R.

Published
2014
Full Text
View/download PDF

2. A genome-wide association study on African-ancestry populations for asthma

Author

Mathias, Rasika A., Grant, Audrey V., Rafaels, Nicholas, Hand, Tracey, Gao, Li, Vergara, Candelaria, Tsai, Yuhjung J., Yang, Mao, Campbell, Monica, Foster, Cassandra, Gao, Peisong, Togias, A., Hansel, Nadia N., Diette, Gregory, Adkinson, N. Franklin, Liu, Mark C., Faruque, Mezbah, Dunston, Georgia M., Watson, Harold R., Bracken, Michael B., Hoh, Josephine, Maul, Pissamai, Maul, Trevor, Jedlicka, Anne E., Murray, Tanda, Hetmanski, Jacqueline B., Ashworth, Roxann, Ongaco, Chrissie M., Hetrick, Kurt N., Doheny, Kimberly F., Pugh, Elizabeth W., Rotimi, Charles N., Ford, Jean, Eng, Celeste, Burchard, Esteban G., Sleiman, Patrick M.A., Hakonarson, Hakon, Forno, Erick, Raby, Benjamin A., Weiss, Scott T., Scott, Alan F., Kabesch, Michael, Liang, Liming, Abecasis, Gonçalo, Moffatt, Miriam F., Cookson, William O.C., Ruczinski, Ingo, Beaty, Terri H., and Barnes, Kathleen C.

Published
2010
Full Text
View/download PDF

4. Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD

Author

Hansel, Nadia N., Ruczinski, Ingo, Rafaels, Nicholas, Sin, Don D., Daley, Denise, Malinina, Alla, Huang, Lili, Sandford, Andrew, Murray, Tanda, Kim, Yoonhee, Vergara, Candelaria, Heckbert, Susan R., Psaty, Bruce M., Li, Guo, Elliott, W. Mark, Aminuddin, Farzian, Dupuis, Josée, O’Connor, George T., Doheny, Kimberly, Scott, Alan F., Boezen, H. Marike, Postma, Dirkje S., Smolonska, Joanna, Zanen, Pieter, Mohamed Hoesein, Firdaus A., de Koning, Harry J., Crystal, Ronald G., Tanaka, Toshiko, Ferrucci, Luigi, Silverman, Edwin, Wan, Emily, Vestbo, Jorgen, Lomas, David A., Connett, John, Wise, Robert A., Neptune, Enid R., Mathias, Rasika A., Paré, Peter D., Beaty, Terri H., and Barnes, Kathleen C.

Published
2013
Full Text
View/download PDF

6. Increased Genetic Vulnerability to Smoking at CHRNA5 in Early-Onset Smokers

Author

Hartz, Sarah M., Short, Susan E., Saccone, Nancy L., Culverhouse, Robert, Chen, LiShiun, Schwantes-An, Tae-Hwi, Coon, Hilary, Han, Younghun, Stephens, Sarah H., Sun, Juzhong, Chen, Xiangning, Ducci, Francesca, Dueker, Nicole, Franceschini, Nora, Frank, Josef, Geller, Frank, Gubjartsson, Daniel, Hansel, Nadia N., Jiang, Chenhui, Keskitalo-Vuokko, Kaisu, Liu, Zhen, Lyytikäinen, Leo-Pekka, Michel, Martha, Rawal, Rajesh, Rosenberger, Albert, Scheet, Paul, Shaffer, John R., Teumer, Alexander, Thompson, John R., Vink, Jacqueline M., Vogelzangs, Nicole, Wenzlaff, Angela S., Wheeler, William, Xiao, Xiangjun, Yang, Bao-Zhu, Aggen, Steven H., Balmforth, Anthony J., Baumeister, Sebastian E., Beaty, Terri, Bennett, Siiri, Bergen, Andrew W., Boyd, Heather A., Broms, Ulla, Campbell, Harry, Chatterjee, Nilanjan, Chen, Jingchun, Cheng, Yu-Ching, Cichon, Sven, Couper, David, Cucca, Francesco, Dick, Danielle M., Foroud, Tatiana, Furberg, Helena, Giegling, Ina, Gu, Fangyi, Hall, Alistair S., Hällfors, Jenni, Han, Shizhong, Hartmann, Annette M., Hayward, Caroline, Heikkilä, Kauko, Hewitt, John K., Hottenga, Jouke Jan, Jensen, Majken K., Jousilahti, Pekka, Kaakinen, Marika, Kittner, Steven J., Konte, Bettina, Korhonen, Tellervo, Landi, Maria-Teresa, Laatikainen, Tiina, Leppert, Mark, Levy, Steven M., Mathias, Rasika A., McNeil, Daniel W., Medland, Sarah E., Montgomery, Grant W., Muley, Thomas, Murray, Tanda, Nauck, Matthias, North, Kari, Pergadia, Michele, Polasek, Ozren, Ramos, Erin M., Ripatti, Samuli, Risch, Angela, Ruczinski, Ingo, Rudan, Igor, Salomaa, Veikko, Schlessinger, David, Styrkársdóttir, Unnur, Terracciano, Antonio, Uda, Manuela, Willemsen, Gonneke, Wu, Xifeng, Abecasis, Goncalo, Barnes, Kathleen, Bickeböller, Heike, Boerwinkle, Eric, Boomsma, Dorret I., Caporaso, Neil, Duan, Jubao, Edenberg, Howard J., Francks, Clyde, Gejman, Pablo V., Gelernter, Joel, Grabe, Hans Jörgen, Hops, Hyman, Jarvelin, Marjo-Riitta, Viikari, Jorma, Kähönen, Mika, Kendler, Kenneth S., Lehtimäki, Terho, Levinson, Douglas F., Marazita, Mary L., Marchini, Jonathan, Melbye, Mads, Mitchell, Braxton D., Murray, Jeffrey C., Nöthen, Markus M., Penninx, Brenda W., Raitakari, Olli, Rietschel, Marcella, Rujescu, Dan, Samani, Nilesh J., Sanders, Alan R., Schwartz, Ann G., Shete, Sanjay, Shi, Jianxin, Spitz, Margaret, Stefansson, Kari, Swan, Gary E., Thorgeirsson, Thorgeir, Völzke, Henry, Wei, Qingyi, Wichmann, H.-Erich, Amos, Christopher I., Breslau, Naomi, Cannon, Dale S., Ehringer, Marissa, Grucza, Richard, Hatsukami, Dorothy, Heath, Andrew, Johnson, Eric O., Kaprio, Jaakko, Madden, Pamela, Martin, Nicholas G., Stevens, Victoria L., Stitzel, Jerry A., Weiss, Robert B., Kraft, Peter, and Bierut, Laura J.

Published
2012
Full Text
View/download PDF

7. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13

Author

Cho, Michael H., Castaldi, Peter J., Wan, Emily S., Siedlinski, Mateusz, Hersh, Craig P., Demeo, Dawn L., Himes, Blanca E., Sylvia, Jody S., Klanderman, Barbara J., Ziniti, John P., Lange, Christoph, Litonjua, Augusto A., Sparrow, David, Regan, Elizabeth A., Make, Barry J., Hokanson, John E., Murray, Tanda, Hetmanski, Jacqueline B., Pillai, Sreekumar G., Kong, Xiangyang, Anderson, Wayne H., Tal-Singer, Ruth, Lomas, David A., Coxson, Harvey O., Edwards, Lisa D., MacNee, William, Vestbo, Jørgen, Yates, Julie C., Agusti, Alvar, Calverley, Peter M.A., Celli, Bartolome, Crim, Courtney, Rennard, Stephen, Wouters, Emiel, Bakke, Per, Gulsvik, Amund, Crapo, James D., Beaty, Terri H., and Silverman, Edwin K.

Published
2012
Full Text
View/download PDF

9. African Ancestry is a Risk Factor for Asthma and High Total IgE Levels in African Admixed Populations

Author

Vergara, Candelaria, Murray, Tanda, Rafaels, Nicholas M., Lewis, Rachel, Campbell, Monica, Foster, Cassandra, Gao, Li, Faruque, Mezbah, Oliveira, Ricardo Riccio, Carvalho Filho, Edgar Marcelino de, Araujo, Maria Ilma Andrade Santos, Cruz Filho, Álvaro Augusto Souza da, Watson, Harold, Mercado, Dilia, Ruczinski, Ingo, Dunston, Georgia, Ford, Jean, Caraballo, Luis, Beaty, Terri H., Mathias, Rasika A., Barnes, Kathleen C., and Knight-Madden, Jennifer

Subjects
Ancestry, African, Asthma
Abstract

Texto completo: acesso restrito. p. 393–401 Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-11-19T11:41:52Z No. of bitstreams: 1 Candelaria Vergara.pdf: 683776 bytes, checksum: 3f244a5ee46560431d06949a67843bd9 (MD5) Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2015-05-05T16:06:05Z (GMT) No. of bitstreams: 1 Candelaria Vergara.pdf: 683776 bytes, checksum: 3f244a5ee46560431d06949a67843bd9 (MD5) Made available in DSpace on 2015-05-05T16:06:05Z (GMT). No. of bitstreams: 1 Candelaria Vergara.pdf: 683776 bytes, checksum: 3f244a5ee46560431d06949a67843bd9 (MD5) Previous issue date: 2013 Characterization of genetic admixture of populations in the Americas and the Caribbean is of interest for anthropological, epidemiological, and historical reasons. Asthma has a higher prevalence and is more severe in populations with a high African component. Association of African ancestry with asthma has been demonstrated. We estimated admixture proportions of samples from six trihybrid populations of African descent and determined the relationship between African ancestry and asthma and total serum IgE levels (tIgE). We genotyped 237 ancestry informative markers in asthmatics and nonasthmatic controls from Barbados (190/277), Jamaica (177/529), Brazil (40/220), Colombia (508/625), African Americans from New York (207/171), and African Americans from Baltimore/Washington, D.C. (625/757). We estimated individual ancestries and evaluated genetic stratification using Structure and principal component analysis. Association of African ancestry and asthma and tIgE was evaluated by regression analysis. Mean ± SD African ancestry ranged from 0.76 ± 0.10 among Barbadians to 0.33 ± 0.13 in Colombians. The European component varied from 0.14 ± 0.05 among Jamaicans and Barbadians to 0.26 ± 0.08 among Colombians. African ancestry was associated with risk for asthma in Colombians (odds ratio (OR) = 4.5, P = 0.001) Brazilians (OR = 136.5, P = 0.003), and African Americans of New York (OR: 4.7; P = 0.040). African ancestry was also associated with higher tIgE levels among Colombians (β = 1.3, P = 0.04), Barbadians (β = 3.8, P = 0.03), and Brazilians (β = 1.6, P = 0.03). Our findings indicate that African ancestry can account for, at least in part, the association between asthma and its associated trait, tIgE levels.

Published
2013
Full Text
View/download PDF

10. Genetic Variants in TSLP are Associated with Atopic Dermatitis and Eczema Herpeticum

Author

Gao, Pei-Song, Rafaels, Nicholas M, Mu, Deguang, Hand, Tracey, Murray, Tanda, Boguniewicz, Mark, Hata, Tissa, Schneider, Lynda, Hanifin, Jon M, Gallo, Richard L, Gao, Li, Beaty, Terri H, Beck, Lisa A, Leung, Donald YM, and Barnes, Kathleen C

Subjects
Receptors, Interleukin-7, DNA Mutational Analysis, Racial Groups, Genetic Variation, Kaposi Varicelliform Eruption, Polymorphism, Single Nucleotide, Article, Dermatitis, Atopic, Gene Frequency, Thymic Stromal Lymphopoietin, Cytokines, Humans, Receptors, Cytokine, Genetic Association Studies
Published
2010

11. Evidence of Gene−Environment Interaction for Two Genes on Chromosome 4 and Environmental Tobacco Smoke in Controlling the Risk of Nonsyndromic Cleft Palate

Author

Wu, Tao, primary, Schwender, Holger, additional, Ruczinski, Ingo, additional, Murray, Jeffrey C., additional, Marazita, Mary L., additional, Munger, Ronald G., additional, Hetmanski, Jacqueline B., additional, Parker, Margaret M., additional, Wang, Ping, additional, Murray, Tanda, additional, Taub, Margaret, additional, Li, Shuai, additional, Redett, Richard J., additional, Fallin, M. Daniele, additional, Liang, Kung Yee, additional, Wu-Chou, Yah Huei, additional, Chong, Samuel S., additional, Yeow, Vincent, additional, Ye, Xiaoqian, additional, Wang, Hong, additional, Huang, Shangzhi, additional, Jabs, Ethylin W., additional, Shi, Bing, additional, Wilcox, Allen J., additional, Jee, Sun Ha, additional, Scott, Alan F., additional, and Beaty, Terri H., additional

Published
2014
Full Text
View/download PDF

12. Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol

Author

Lange, Leslie A., primary, Hu, Youna, additional, Zhang, He, additional, Xue, Chenyi, additional, Schmidt, Ellen M., additional, Tang, Zheng-Zheng, additional, Bizon, Chris, additional, Lange, Ethan M., additional, Smith, Joshua D., additional, Turner, Emily H., additional, Jun, Goo, additional, Kang, Hyun Min, additional, Peloso, Gina, additional, Auer, Paul, additional, Li, Kuo-ping, additional, Flannick, Jason, additional, Zhang, Ji, additional, Fuchsberger, Christian, additional, Gaulton, Kyle, additional, Lindgren, Cecilia, additional, Locke, Adam, additional, Manning, Alisa, additional, Sim, Xueling, additional, Rivas, Manuel A., additional, Holmen, Oddgeir L., additional, Gottesman, Omri, additional, Lu, Yingchang, additional, Ruderfer, Douglas, additional, Stahl, Eli A., additional, Duan, Qing, additional, Li, Yun, additional, Durda, Peter, additional, Jiao, Shuo, additional, Isaacs, Aaron, additional, Hofman, Albert, additional, Bis, Joshua C., additional, Correa, Adolfo, additional, Griswold, Michael E., additional, Jakobsdottir, Johanna, additional, Smith, Albert V., additional, Schreiner, Pamela J., additional, Feitosa, Mary F., additional, Zhang, Qunyuan, additional, Huffman, Jennifer E., additional, Crosby, Jacy, additional, Wassel, Christina L., additional, Do, Ron, additional, Franceschini, Nora, additional, Martin, Lisa W., additional, Robinson, Jennifer G., additional, Assimes, Themistocles L., additional, Crosslin, David R., additional, Rosenthal, Elisabeth A., additional, Tsai, Michael, additional, Rieder, Mark J., additional, Farlow, Deborah N., additional, Folsom, Aaron R., additional, Lumley, Thomas, additional, Fox, Ervin R., additional, Carlson, Christopher S., additional, Peters, Ulrike, additional, Jackson, Rebecca D., additional, van Duijn, Cornelia M., additional, Uitterlinden, André G., additional, Levy, Daniel, additional, Rotter, Jerome I., additional, Taylor, Herman A., additional, Gudnason, Vilmundur, additional, Siscovick, David S., additional, Fornage, Myriam, additional, Borecki, Ingrid B., additional, Hayward, Caroline, additional, Rudan, Igor, additional, Chen, Y. Eugene, additional, Bottinger, Erwin P., additional, Loos, Ruth J.F., additional, Sætrom, Pål, additional, Hveem, Kristian, additional, Boehnke, Michael, additional, Groop, Leif, additional, McCarthy, Mark, additional, Meitinger, Thomas, additional, Ballantyne, Christie M., additional, Gabriel, Stacey B., additional, O’Donnell, Christopher J., additional, Post, Wendy S., additional, North, Kari E., additional, Reiner, Alexander P., additional, Boerwinkle, Eric, additional, Psaty, Bruce M., additional, Altshuler, David, additional, Kathiresan, Sekar, additional, Lin, Dan-Yu, additional, Jarvik, Gail P., additional, Cupples, L. Adrienne, additional, Kooperberg, Charles, additional, Wilson, James G., additional, Nickerson, Deborah A., additional, Abecasis, Goncalo R., additional, Rich, Stephen S., additional, Tracy, Russell P., additional, Willer, Cristen J., additional, Altshuler, David M., additional, Abecasis, Gonçalo R., additional, Allayee, Hooman, additional, Cresci, Sharon, additional, Daly, Mark J., additional, de Bakker, Paul I.W., additional, DePristo, Mark A., additional, Donnelly, Peter, additional, Fennell, Tim, additional, Garimella, Kiran, additional, Hazen, Stanley L., additional, Jordan, Daniel M., additional, Kiezun, Adam, additional, Lettre, Guillaume, additional, Li, Bingshan, additional, Li, Mingyao, additional, Newton-Cheh, Christopher H., additional, Padmanabhan, Sandosh, additional, Pulit, Sara, additional, Rader, Daniel J., additional, Reich, David, additional, Reilly, Muredach P., additional, Schwartz, Steve, additional, Scott, Laura, additional, Spertus, John A., additional, Stitziel, Nathaniel O., additional, Stoletzki, Nina, additional, Sunyaev, Shamil R., additional, Voight, Benjamin F., additional, Akylbekova, Ermeg, additional, Atwood, Larry D., additional, Barbalic, Maja, additional, Barr, R. Graham, additional, Benjamin, Emelia J., additional, Bis, Joshua, additional, Bowden, Donald W., additional, Brody, Jennifer, additional, Budoff, Matthew, additional, Burke, Greg, additional, Buxbaum, Sarah, additional, Carr, Jeff, additional, Chen, Donna T., additional, Chen, Ida Y., additional, Chen, Wei-Min, additional, Concannon, Pat, additional, D’Agostino, Ralph, additional, DeStefano, Anita L., additional, Dreisbach, Albert, additional, Dupuis, Josée, additional, Durda, J. Peter, additional, Ellis, Jaclyn, additional, Fox, Caroline S., additional, Fox, Ervin, additional, Funari, Vincent, additional, Ganesh, Santhi K., additional, Gardin, Julius, additional, Goff, David, additional, Gordon, Ora, additional, Grody, Wayne, additional, Gross, Myron, additional, Guo, Xiuqing, additional, Hall, Ira M., additional, Heard-Costa, Nancy L., additional, Heckbert, Susan R., additional, Heintz, Nicholas, additional, Herrington, David M., additional, Hickson, DeMarc, additional, Huang, Jie, additional, Hwang, Shih-Jen, additional, Jacobs, David R., additional, Jenny, Nancy S., additional, Johnson, Andrew D., additional, Johnson, Craig W., additional, Kawut, Steven, additional, Kronmal, Richard, additional, Kurz, Raluca, additional, Lange, Leslie A., additional, Larson, Martin G., additional, Lawson, Mark, additional, Lewis, Cora E., additional, Li, Dalin, additional, Lin, Honghuang, additional, Liu, Chunyu, additional, Liu, Jiankang, additional, Liu, Kiang, additional, Liu, Xiaoming, additional, Liu, Yongmei, additional, Longstreth, William T., additional, Loria, Cay, additional, Lunetta, Kathryn, additional, Mackey, Aaron J., additional, Mackey, Rachel, additional, Manichaikul, Ani, additional, Maxwell, Taylor, additional, McKnight, Barbara, additional, Meigs, James B., additional, Morrison, Alanna C., additional, Musani, Solomon K., additional, Mychaleckyj, Josyf C., additional, Nettleton, Jennifer A., additional, North, Kari, additional, O’Leary, Daniel, additional, Ong, Frank, additional, Palmas, Walter, additional, Pankow, James S., additional, Pankratz, Nathan D., additional, Paul, Shom, additional, Perez, Marco, additional, Person, Sharina D., additional, Polak, Joseph, additional, Quinlan, Aaron R., additional, Raffel, Leslie J., additional, Ramachandran, Vasan S., additional, Rice, Kenneth, additional, Sanders, Jill P., additional, Schreiner, Pamela, additional, Seshadri, Sudha, additional, Shea, Steve, additional, Sidney, Stephen, additional, Silverstein, Kevin, additional, Smith, Nicholas L., additional, Sotoodehnia, Nona, additional, Srinivasan, Asoke, additional, Taylor, Kent, additional, Thomas, Fridtjof, additional, Tsai, Michael Y., additional, Volcik, Kelly A., additional, Wassel, Chrstina L., additional, Watson, Karol, additional, Wei, Gina, additional, White, Wendy, additional, Wiggins, Kerri L., additional, Wilk, Jemma B., additional, Williams, O. Dale, additional, Wilson, Gregory, additional, Wolf, Phillip, additional, Zakai, Neil A., additional, Hardy, John, additional, Meschia, James F., additional, Nalls, Michael, additional, Singleton, Andrew, additional, Worrall, Brad, additional, Bamshad, Michael J., additional, Barnes, Kathleen C., additional, Abdulhamid, Ibrahim, additional, Accurso, Frank, additional, Anbar, Ran, additional, Beaty, Terri, additional, Bigham, Abigail, additional, Black, Phillip, additional, Bleecker, Eugene, additional, Buckingham, Kati, additional, Cairns, Anne Marie, additional, Caplan, Daniel, additional, Chatfield, Barbara, additional, Chidekel, Aaron, additional, Cho, Michael, additional, Christiani, David C., additional, Crapo, James D., additional, Crouch, Julia, additional, Daley, Denise, additional, Dang, Anthony, additional, Dang, Hong, additional, De Paula, Alicia, additional, DeCelie-Germana, Joan, additional, Drumm, Allen DozorMitch, additional, Dyson, Maynard, additional, Emerson, Julia, additional, Emond, Mary J., additional, Ferkol, Thomas, additional, Fink, Robert, additional, Foster, Cassandra, additional, Froh, Deborah, additional, Gao, Li, additional, Gershan, William, additional, Gibson, Ronald L., additional, Godwin, Elizabeth, additional, Gondor, Magdalen, additional, Gutierrez, Hector, additional, Hansel, Nadia N., additional, Hassoun, Paul M., additional, Hiatt, Peter, additional, Hokanson, John E., additional, Howenstine, Michelle, additional, Hummer, Laura K., additional, Kanga, Jamshed, additional, Kim, Yoonhee, additional, Knowles, Michael R., additional, Konstan, Michael, additional, Lahiri, Thomas, additional, Laird, Nan, additional, Lange, Christoph, additional, Lin, Lin, additional, Lin, Xihong, additional, Louie, Tin L., additional, Lynch, David, additional, Make, Barry, additional, Martin, Thomas R., additional, Mathai, Steve C., additional, Mathias, Rasika A., additional, McNamara, John, additional, McNamara, Sharon, additional, Meyers, Deborah, additional, Millard, Susan, additional, Mogayzel, Peter, additional, Moss, Richard, additional, Murray, Tanda, additional, Nielson, Dennis, additional, Noyes, Blakeslee, additional, O’Neal, Wanda, additional, Orenstein, David, additional, O’Sullivan, Brian, additional, Pace, Rhonda, additional, Pare, Peter, additional, Parker, H. Worth, additional, Passero, Mary Ann, additional, Perkett, Elizabeth, additional, Prestridge, Adrienne, additional, Rafaels, Nicholas M., additional, Ramsey, Bonnie, additional, Regan, Elizabeth, additional, Ren, Clement, additional, Retsch-Bogart, George, additional, Rock, Michael, additional, Rosen, Antony, additional, Rosenfeld, Margaret, additional, Ruczinski, Ingo, additional, Sanford, Andrew, additional, Schaeffer, David, additional, Sell, Cindy, additional, Sheehan, Daniel, additional, Silverman, Edwin K., additional, Sin, Don, additional, Spencer, Terry, additional, Stonebraker, Jackie, additional, Tabor, Holly K., additional, Varlotta, Laurie, additional, Vergara, Candelaria I., additional, Weiss, Robert, additional, Wigley, Fred, additional, Wise, Robert A., additional, Wright, Fred A., additional, Wurfel, Mark M., additional, Zanni, Robert, additional, Zou, Fei, additional, Green, Phil, additional, Shendure, Jay, additional, Akey, Joshua M., additional, Bustamante, Carlos D., additional, Eichler, Evan E., additional, Fox, P. Keolu, additional, Fu, Wenqing, additional, Gordon, Adam, additional, Gravel, Simon, additional, Johnsen, Jill M., additional, Kan, Mengyuan, additional, Kenny, Eimear E., additional, Kidd, Jeffrey M., additional, Lara-Garduno, Fremiet, additional, Leal, Suzanne M., additional, Liu, Dajiang J., additional, McGee, Sean, additional, O’Connor, Timothy D., additional, Paeper, Bryan, additional, Robertson, Peggy D., additional, Staples, Jeffrey C., additional, Tennessen, Jacob A., additional, Wang, Gao, additional, Yi, Qian, additional, Jackson, Rebecca, additional, Anderson, Garnet, additional, Anton-Culver, Hoda, additional, Auer, Paul L., additional, Beresford, Shirley, additional, Black, Henry, additional, Brunner, Robert, additional, Brzyski, Robert, additional, Burwen, Dale, additional, Caan, Bette, additional, Carty, Cara L., additional, Chlebowski, Rowan, additional, Cummings, Steven, additional, Curb, J. David, additional, Eaton, Charles B., additional, Ford, Leslie, additional, Fullerton, Stephanie M., additional, Gass, Margery, additional, Geller, Nancy, additional, Heiss, Gerardo, additional, Howard, Barbara V., additional, Hsu, Li, additional, Hutter, Carolyn M., additional, Ioannidis, John, additional, Johnson, Karen C., additional, Kuller, Lewis, additional, LaCroix, Andrea, additional, Lakshminarayan, Kamakshi, additional, Lane, Dorothy, additional, Lasser, Norman, additional, LeBlanc, Erin, additional, Li, Kuo-Ping, additional, Limacher, Marian, additional, Logsdon, Benjamin A., additional, Ludlam, Shari, additional, Manson, JoAnn E., additional, Margolis, Karen, additional, Martin, Lisa, additional, McGowan, Joan, additional, Monda, Keri L., additional, Kotchen, Jane Morley, additional, Nathan, Lauren, additional, Ockene, Judith, additional, O’Sullivan, Mary Jo, additional, Phillips, Lawrence S., additional, Prentice, Ross L., additional, Robbins, John, additional, Rossouw, Jacques E., additional, Sangi-Haghpeykar, Haleh, additional, Sarto, Gloria E., additional, Shumaker, Sally, additional, Simon, Michael S., additional, Stefanick, Marcia L., additional, Stein, Evan, additional, Tang, Hua, additional, Taylor, Kira C., additional, Thomson, Cynthia A., additional, Thornton, Timothy A., additional, Van Horn, Linda, additional, Vitolins, Mara, additional, Wactawski-Wende, Jean, additional, Wallace, Robert, additional, Wassertheil-Smoller, Sylvia, additional, Zeng, Donglin, additional, Applebaum-Bowden, Deborah, additional, Feolo, Michael, additional, Gan, Weiniu, additional, Paltoo, Dina N., additional, Sholinsky, Phyliss, additional, and Sturcke, Anne, additional

Published
2014
Full Text
View/download PDF

13. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13

Author

Cho, Michael H, Castaldi, Peter J, Wan, Emily S, Siedlinski, Mateusz, Hersh, Craig P, Demeo, Dawn L, Himes, Blanca E, Sylvia, Jody S, Klanderman, Barbara J, Ziniti, John P, Lange, Christoph, Litonjua, Augusto A, Sparrow, David, Regan, Elizabeth A, Make, Barry J, Hokanson, John E, Murray, Tanda, Hetmanski, Jacqueline B, Pillai, Sreekumar G, Kong, Xiangyang, Anderson, Wayne H, Tal-Singer, Ruth, Lomas, David A, Coxson, Harvey O, Edwards, Lisa D, MacNee, William, Vestbo, Jørgen, Yates, Julie C, Agusti, Alvar, Calverley, Peter M A, Celli, Bartolome, Crim, Courtney, Rennard, Stephen, Wouters, Emiel, Bakke, Per, Gulsvik, Amund, Crapo, James D, Beaty, Terri H, Silverman, Edwin K, Cho, Michael H, Castaldi, Peter J, Wan, Emily S, Siedlinski, Mateusz, Hersh, Craig P, Demeo, Dawn L, Himes, Blanca E, Sylvia, Jody S, Klanderman, Barbara J, Ziniti, John P, Lange, Christoph, Litonjua, Augusto A, Sparrow, David, Regan, Elizabeth A, Make, Barry J, Hokanson, John E, Murray, Tanda, Hetmanski, Jacqueline B, Pillai, Sreekumar G, Kong, Xiangyang, Anderson, Wayne H, Tal-Singer, Ruth, Lomas, David A, Coxson, Harvey O, Edwards, Lisa D, MacNee, William, Vestbo, Jørgen, Yates, Julie C, Agusti, Alvar, Calverley, Peter M A, Celli, Bartolome, Crim, Courtney, Rennard, Stephen, Wouters, Emiel, Bakke, Per, Gulsvik, Amund, Crapo, James D, Beaty, Terri H, and Silverman, Edwin K

Abstract

The genetic risk factors for chronic obstructive pulmonary disease (COPD) are still largely unknown. To date, genome-wide association studies (GWASs) of limited size have identified several novel risk loci for COPD at CHRNA3/CHRNA5/IREB2, HHIP and FAM13A; additional loci may be identified through larger studies. We performed a GWAS using a total of 3499 cases and 1922 control subjects from four cohorts: the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE); the Normative Aging Study (NAS) and National Emphysema Treatment Trial (NETT); Bergen, Norway (GenKOLS); and the COPDGene study. Genotyping was performed on Illumina platforms with additional markers imputed using 1000 Genomes data; results were summarized using fixed-effect meta-analysis. We identified a new genome-wide significant locus on chromosome 19q13 (rs7937, OR = 0.74, P = 2.9 × 10(-9)). Genotyping this single nucleotide polymorphism (SNP) and another nearby SNP in linkage disequilibrium (rs2604894) in 2859 subjects from the family-based International COPD Genetics Network study (ICGN) demonstrated supportive evidence for association for COPD (P = 0.28 and 0.11 for rs7937 and rs2604894), pre-bronchodilator FEV(1) (P = 0.08 and 0.04) and severe (GOLD 3&4) COPD (P = 0.09 and 0.017). This region includes RAB4B, EGLN2, MIA and CYP2A6, and has previously been identified in association with cigarette smoking behavior.

Published
2012

14. A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4

Author

Beaty, Terri H., Melbye, Mads, Murray, Jeffrey C., Marazita, Mary L., Munger, Ronald G., Ruczinski, Ingo, Hetmanski, Jacqueline B., Liang, Kung Yee, Wu, Tao, Murray, Tanda, Arcos-Burgos, Mauricio, Cooper, Margaret E., Beaty, Terri H., Melbye, Mads, Murray, Jeffrey C., Marazita, Mary L., Munger, Ronald G., Ruczinski, Ingo, Hetmanski, Jacqueline B., Liang, Kung Yee, Wu, Tao, Murray, Tanda, Arcos-Burgos, Mauricio, and Cooper, Margaret E.

Abstract

Case-parent trios were used in a genome-wide association study of cleft lip with and without cleft palate. SNPs near two genes not previously associated with cleft lip with and without cleft palate (MAFB, most significant SNP rs13041247, with odds ratio (OR) per minor allele = 0.704, 95% CI 0.635-0.778, P = 1.44 × 10-11; and ABCA4, most significant SNP rs560426, with OR = 1.432, 95% CI 1.292-1.587, P = 5.01 × 10-12) and two previously identified regions (at chromosome 8q24 and IRF6) attained genome-wide significance. Stratifying trios into European and Asian ancestry groups revealed differences in statistical significance, although estimated effect sizes remained similar. Replication studies from several populations showed confirming evidence, with families of European ancestry giving stronger evidence for markers in 8q24, whereas Asian families showed stronger evidence for association with MAFB and ABCA4. Expression studies support a role for MAFB in palatal development.

Published
2010

15. Distinct Loci in theCHRNA5/CHRNA3/CHRNB4Gene Cluster Are Associated With Onset of Regular Smoking

Author

Stephens, Sarah H., primary, Hartz, Sarah M., additional, Hoft, Nicole R., additional, Saccone, Nancy L., additional, Corley, Robin C., additional, Hewitt, John K., additional, Hopfer, Christian J., additional, Breslau, Naomi, additional, Coon, Hilary, additional, Chen, Xiangning, additional, Ducci, Francesca, additional, Dueker, Nicole, additional, Franceschini, Nora, additional, Frank, Josef, additional, Han, Younghun, additional, Hansel, Nadia N., additional, Jiang, Chenhui, additional, Korhonen, Tellervo, additional, Lind, Penelope A., additional, Liu, Jason, additional, Lyytikäinen, Leo-Pekka, additional, Michel, Martha, additional, Shaffer, John R., additional, Short, Susan E., additional, Sun, Juzhong, additional, Teumer, Alexander, additional, Thompson, John R., additional, Vogelzangs, Nicole, additional, Vink, Jacqueline M., additional, Wenzlaff, Angela, additional, Wheeler, William, additional, Yang, Bao-Zhu, additional, Aggen, Steven H., additional, Balmforth, Anthony J., additional, Baumeister, Sebastian E., additional, Beaty, Terri H., additional, Benjamin, Daniel J., additional, Bergen, Andrew W., additional, Broms, Ulla, additional, Cesarini, David, additional, Chatterjee, Nilanjan, additional, Chen, Jingchun, additional, Cheng, Yu-Ching, additional, Cichon, Sven, additional, Couper, David, additional, Cucca, Francesco, additional, Dick, Danielle, additional, Foroud, Tatiana, additional, Furberg, Helena, additional, Giegling, Ina, additional, Gillespie, Nathan A., additional, Gu, Fangyi, additional, Hall, Alistair S., additional, Hällfors, Jenni, additional, Han, Shizhong, additional, Hartmann, Annette M., additional, Heikkilä, Kauko, additional, Hickie, Ian B., additional, Hottenga, Jouke Jan, additional, Jousilahti, Pekka, additional, Kaakinen, Marika, additional, Kähönen, Mika, additional, Koellinger, Philipp D., additional, Kittner, Stephen, additional, Konte, Bettina, additional, Landi, Maria-Teresa, additional, Laatikainen, Tiina, additional, Leppert, Mark, additional, Levy, Steven M., additional, Mathias, Rasika A., additional, McNeil, Daniel W., additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Murray, Tanda, additional, Nauck, Matthias, additional, North, Kari E., additional, Paré, Peter D., additional, Pergadia, Michele, additional, Ruczinski, Ingo, additional, Salomaa, Veikko, additional, Viikari, Jorma, additional, Willemsen, Gonneke, additional, Barnes, Kathleen C., additional, Boerwinkle, Eric, additional, Boomsma, Dorret I., additional, Caporaso, Neil, additional, Edenberg, Howard J., additional, Francks, Clyde, additional, Gelernter, Joel, additional, Grabe, Hans Jörgen, additional, Hops, Hyman, additional, Jarvelin, Marjo-Riitta, additional, Johannesson, Magnus, additional, Kendler, Kenneth S., additional, Lehtimäki, Terho, additional, Magnusson, Patrik K.E., additional, Marazita, Mary L., additional, Marchini, Jonathan, additional, Mitchell, Braxton D., additional, Nöthen, Markus M., additional, Penninx, Brenda W., additional, Raitakari, Olli, additional, Rietschel, Marcella, additional, Rujescu, Dan, additional, Samani, Nilesh J., additional, Schwartz, Ann G., additional, Shete, Sanjay, additional, Spitz, Margaret, additional, Swan, Gary E., additional, Völzke, Henry, additional, Veijola, Juha, additional, Wei, Qingyi, additional, Amos, Chris, additional, Cannon, Dale S., additional, Grucza, Richard, additional, Hatsukami, Dorothy, additional, Heath, Andrew, additional, Johnson, Eric O., additional, Kaprio, Jaakko, additional, Madden, Pamela, additional, Martin, Nicholas G., additional, Stevens, Victoria L., additional, Weiss, Robert B., additional, Kraft, Peter, additional, Bierut, Laura J., additional, and Ehringer, Marissa A., additional

Published
2013
Full Text
View/download PDF

16. African Ancestry is a Risk Factor for Asthma and High Total IgE Levels in African Admixed Populations

Author

Vergara, Candelaria, primary, Murray, Tanda, additional, Rafaels, Nicholas, additional, Lewis, Rachel, additional, Campbell, Monica, additional, Foster, Cassandra, additional, Gao, Li, additional, Faruque, Mezbah, additional, Oliveira, Ricardo Riccio, additional, Carvalho, Edgar, additional, Araujo, Maria Ilma, additional, Cruz, Alvaro A., additional, Watson, Harold, additional, Mercado, Dilia, additional, Knight‐Madden, Jennifer, additional, Ruczinski, Ingo, additional, Dunston, Georgia, additional, Ford, Jean, additional, Caraballo, Luis, additional, Beaty, Terri H., additional, Mathias, Rasika A., additional, and Barnes, Kathleen C., additional

Published
2013
Full Text
View/download PDF

17. TheFGFandFGFRGene Family and Risk of Cleft Lip with or Without Cleft Palate

Author

Wang, Hong, primary, Zhang, Tianxiao, additional, Wu, Tao, additional, Hetmanski, Jacqueline B., additional, Ruczinski, Ingo, additional, Schwender, Holger, additional, Yee Liang, Kung, additional, Murray, Tanda, additional, Daniele Fallin, M., additional, Redett, Richard J., additional, Raymond, Gerald V., additional, Jin, Sheng-Chih, additional, Wu Chou, Yah-Huei, additional, Kuo-Ting Chen, Philip, additional, Yeow, Vincent, additional, Chong, Samuel S., additional, Cheah, Felicia S.H., additional, Ha Jee, Sun, additional, Jabs, Ethylin W., additional, Scott, Alan F., additional, and Beaty, Terri H., additional

Published
2013
Full Text
View/download PDF

18. Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD

Author

Hansel, Nadia N., primary, Ruczinski, Ingo, additional, Rafaels, Nicholas, additional, Sin, Don D., additional, Daley, Denise, additional, Malinina, Alla, additional, Huang, Lili, additional, Sandford, Andrew, additional, Murray, Tanda, additional, Kim, Yoonhee, additional, Vergara, Candelaria, additional, Heckbert, Susan R., additional, Psaty, Bruce M., additional, Li, Guo, additional, Elliott, W. Mark, additional, Aminuddin, Farzian, additional, Dupuis, Josée, additional, O’Connor, George T., additional, Doheny, Kimberly, additional, Scott, Alan F., additional, Boezen, H. Marike, additional, Postma, Dirkje S., additional, Smolonska, Joanna, additional, Zanen, Pieter, additional, Mohamed Hoesein, Firdaus A., additional, de Koning, Harry J., additional, Crystal, Ronald G., additional, Tanaka, Toshiko, additional, Ferrucci, Luigi, additional, Silverman, Edwin, additional, Wan, Emily, additional, Vestbo, Jorgen, additional, Lomas, David A., additional, Connett, John, additional, Wise, Robert A., additional, Neptune, Enid R., additional, Mathias, Rasika A., additional, Paré, Peter D., additional, Beaty, Terri H., additional, and Barnes, Kathleen C., additional

Published
2012
Full Text
View/download PDF

19. Exome Sequencing Identifies Rare Functional Coding Variants In HK2, MTRR And DCAF5 That Determine Lung Function Decline In COPD

Author

Mathias, Rasika A., primary, Kim, Yoonhee, additional, Taub, Margaret, additional, Huang, Lili, additional, Rafaels, Nicholas, additional, Murray, Tanda, additional, Vergara, Candelaria, additional, Emond, Mary, additional, Beaty, Terri, additional, Ruczinski, Ingo, additional, Hansel, Nadia, additional, Bamshad, Michael, additional, and Barnes, Kathleen C., additional

Published
2012
Full Text
View/download PDF

20. IL33 Gene Polymorphisms Associated With Asthma Are Related With Resistance To Schistosoma Mansoni

Author

Barnes, Kathleen C., primary, Gao, Li, additional, Rafaels, Nicholas M., additional, Cordell, Jareau V., additional, Vergara, Candelaria, additional, Figueiredo, Camila, additional, Murray, Tanda, additional, Campbell, Monica, additional, Grant, Audrey V., additional, Oliveira, Ricardo R., additional, Cruz, Alvaro A., additional, Carvalho, Edgar M., additional, Ruczinski, Ingo, additional, Beaty, Terri H., additional, Mathias, Rasika A., additional, and Araujo, Maria I., additional

Published
2012
Full Text
View/download PDF

21. Examining Markers in 8q24 to Explain Differences in Evidence for Association With Cleft Lip With/Without Cleft Palate Between Asians and Europeans

Author

Murray, Tanda, primary, Taub, Margaret A., additional, Ruczinski, Ingo, additional, Scott, Alan F., additional, Hetmanski, Jacqueline B., additional, Schwender, Holger, additional, Patel, Poorav, additional, Zhang, Tian Xiao, additional, Munger, Ronald G., additional, Wilcox, Allen J., additional, Ye, Xiaoqian, additional, Wang, Hong, additional, Wu, Tao, additional, Wu-Chou, Yah Huei, additional, Shi, Bing, additional, Jee, Sun Ha, additional, Chong, Samuel, additional, Yeow, Vincent, additional, Murray, Jeffrey C., additional, Marazita, Mary L., additional, and Beaty, Terri H., additional

Published
2012
Full Text
View/download PDF

22. Genome wide study of maternal and parent‐of‐origin effects on the etiology of orofacial clefts

Author

Shi, Min, primary, Murray, Jeffrey C., additional, Marazita, Mary L., additional, Munger, Ronald G., additional, Ruczinski, Ingo, additional, Hetmanski, Jacqueline B., additional, Wu, Tao, additional, Murray, Tanda, additional, Redett, Richard J., additional, Wilcox, Allen J., additional, Lie, Rolv T., additional, Jabs, Ethylin Wang, additional, Wu‐Chou, Yah Huei, additional, Chen, Philip K., additional, Wang, Hong, additional, Ye, Xiaoqian, additional, Yeow, Vincent, additional, Chong, Samuel S., additional, Shi, Bing, additional, Christensen, Kaare, additional, Scott, Alan F., additional, Patel, Poorav, additional, Cheah, Felicia, additional, and Beaty, Terri H., additional

Published
2012
Full Text
View/download PDF

23. ORMDL3 And GSDML Gene Variants Associated With Risk And Severity Of Acute Lung Injury

Author

Gao, Li, primary, Murray, Tanda, additional, Campbell, Monica, additional, Rafaels, Nicholas, additional, Maloney, James P., additional, Moss, Marc, additional, Martin, Gregory S., additional, Shanholtz, Carl, additional, Herr, Daniel, additional, Sevransky, Jonathan, additional, Garcia, Joe G., additional, Moffatt, Miriam F., additional, Cookson, William O., additional, Beaty, Terri H., additional, Brower, Roy, additional, and Barnes, Kathleen, additional

Published
2011
Full Text
View/download PDF

24. A Genome-Wide Association Study In COPD Identifies A Susceptibility Locus On Chromosome 19q13

Author

Cho, Michael H., primary, Castaldi, Peter, additional, Hersh, Craig P., additional, DeMeo, Dawn L., additional, Klanderman, Barbara J., additional, Sylvia, Jody, additional, Ziniti, John, additional, Lange, Christoph, additional, Litonjua, Augusto A., additional, Sparrow, David, additional, Murphy, James, additional, Regan, Elizabeth, additional, Make, Barry J., additional, Hokanson, John E., additional, Murray, Tanda, additional, Hetmanski, Jacqueline, additional, Pillai, Sreekumar, additional, Kong, Xiangyang, additional, Anderson, Wayne, additional, Tal-Singer, Ruth, additional, Lomas, David A., additional, Bakke, Per, additional, Gulsvik, Amund, additional, Crapo, James D., additional, Beaty, Terri H., additional, Silverman, Edwin K., additional, and on behalf of the ICGN, ECLIPSE, and, &, additional

Published
2011
Full Text
View/download PDF

25. Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate

Author

Beaty, Terri H., primary, Ruczinski, Ingo, additional, Murray, Jeffrey C., additional, Marazita, Mary L., additional, Munger, Ronald G., additional, Hetmanski, Jacqueline B., additional, Murray, Tanda, additional, Redett, Richard J., additional, Fallin, M. Daniele, additional, Liang, Kung Yee, additional, Wu, Tao, additional, Patel, Poorav J., additional, Jin, Sheng-Chih, additional, Zhang, Tian Xiao, additional, Schwender, Holger, additional, Wu-Chou, Yah Huei, additional, Chen, Philip K., additional, Chong, Samuel S., additional, Cheah, Felicia, additional, Yeow, Vincent, additional, Ye, Xiaoqian, additional, Wang, Hong, additional, Huang, Shangzhi, additional, Jabs, Ethylin W., additional, Shi, Bing, additional, Wilcox, Allen J., additional, Lie, Rolv T., additional, Jee, Sun Ha, additional, Christensen, Kaare, additional, Doheny, Kimberley F., additional, Pugh, Elizabeth W., additional, Ling, Hua, additional, and Scott, Alan F., additional

Published
2011
Full Text
View/download PDF

27. Erratum: A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4

Author

Beaty, Terri H, primary, Murray, Jeffrey C, additional, Marazita, Mary L, additional, Munger, Ronald G, additional, Hetmanski, Ingo Ruczinski Jacqueline B, additional, Liang, Kung Yee, additional, Wu, Tao, additional, Murray, Tanda, additional, Fallin, M Daniele, additional, Redett, Richard A, additional, Raymond, Gerald, additional, Schwender, Holger, additional, Jin, Shin C, additional, Cooper, Margaret E, additional, Dunnwald, Martine, additional, Mansilla, Maria A, additional, Leslie, Elizabeth, additional, Bullard, Stephen, additional, Lidral, Andrew C, additional, Moreno, Lina M, additional, Menezes, Renato, additional, Vieira, Alexandre R, additional, Petrin, Aline, additional, Wilcox, Allen J, additional, Lie, Rolv T, additional, Jabs, Ethylin W, additional, Wu-Chou, Yah Huei, additional, Chen, Philip K, additional, Wang, Hong, additional, Ye, Xiaoqian, additional, Huang, Shangzhi, additional, Yeow, Vincent, additional, Chong, Samuel S, additional, Jee, Sun Ha, additional, Shi, Bing, additional, Christensen, Kaare, additional, Melbye, Mads, additional, Doheny, Kimberly F, additional, Pugh, Elizabeth W, additional, Ling, Hua, additional, Castilla, Eduardo E, additional, Czeizel, Andrew E, additional, Ma, Lian, additional, Field, L Leigh, additional, Brody, Lawrence, additional, Pangilinan, Faith, additional, Mills, James L, additional, Molloy, Anne M, additional, Kirke, Peadar N, additional, Scott, James M, additional, Arcos-Burgos, Mauricio, additional, and Scott, Alan F, additional

Published
2010
Full Text
View/download PDF

28. A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4

Author

Beaty, Terri H, primary, Murray, Jeffrey C, additional, Marazita, Mary L, additional, Munger, Ronald G, additional, Ruczinski, Ingo, additional, Hetmanski, Jacqueline B, additional, Liang, Kung Yee, additional, Wu, Tao, additional, Murray, Tanda, additional, Fallin, M Daniele, additional, Redett, Richard A, additional, Raymond, Gerald, additional, Schwender, Holger, additional, Jin, Sheng-Chih, additional, Cooper, Margaret E, additional, Dunnwald, Martine, additional, Mansilla, Maria A, additional, Leslie, Elizabeth, additional, Bullard, Stephen, additional, Lidral, Andrew C, additional, Moreno, Lina M, additional, Menezes, Renato, additional, Vieira, Alexandre R, additional, Petrin, Aline, additional, Wilcox, Allen J, additional, Lie, Rolv T, additional, Jabs, Ethylin W, additional, Wu-Chou, Yah Huei, additional, Chen, Philip K, additional, Wang, Hong, additional, Ye, Xiaoqian, additional, Huang, Shangzhi, additional, Yeow, Vincent, additional, Chong, Samuel S, additional, Jee, Sun Ha, additional, Shi, Bing, additional, Christensen, Kaare, additional, Melbye, Mads, additional, Doheny, Kimberly F, additional, Pugh, Elizabeth W, additional, Ling, Hua, additional, Castilla, Eduardo E, additional, Czeizel, Andrew E, additional, Ma, Lian, additional, Field, L Leigh, additional, Brody, Lawrence, additional, Pangilinan, Faith, additional, Mills, James L, additional, Molloy, Anne M, additional, Kirke, Peadar N, additional, Scott, John M, additional, Arcos-Burgos, Mauricio, additional, and Scott, Alan F, additional

Published
2010
Full Text
View/download PDF

29. Association between genes on chromosome 4p16 and non-syndromic oral clefts in four populations

Author

Ingersoll, Roxann G, primary, Hetmanski, Jacqueline, additional, Park, Ji-Wan, additional, Fallin, M Daniele, additional, McIntosh, Iain, additional, Wu-Chou, Yah-Huei, additional, Chen, Philip K, additional, Yeow, Vincent, additional, Chong, Samuel S, additional, Cheah, Felicia, additional, Sull, Jae Woong, additional, Jee, Sun Ha, additional, Wang, Hong, additional, Wu, Tao, additional, Murray, Tanda, additional, Huang, Shangzhi, additional, Ye, Xiaoqian, additional, Jabs, Ethylin Wang, additional, Redett, Richard, additional, Raymond, Gerald, additional, Scott, Alan F, additional, and Beaty, Terri H, additional

Published
2010
Full Text
View/download PDF

30. The FGF and FGFR Gene Family and Risk of Cleft Lip With or Without Cleft Palate.

Author

Hong Wang, Tianxiao Zhang, Tao Wu, Hetmanski, Jacqueline B., Ruczinski, Ingo, Schwender, Holger, Kung Vee Liang, Murray, Tanda, Fallin, M. Daniele, Redett, Richard J., Raymond, Gerald V., Sheng-Chih Jin, Wu Chou, Yah-Huei, Chen, Philip Kuo-Ting, Yeow, Vincent, Chong, Samuel S., Cheah, Felicia S. H., Sun Ha Jee, Jabs, Ethylin W., and Scott, Alan F.

Subjects
CLEFT lip, CHI-squared test, CONFIDENCE intervals, EPIDEMIOLOGY, GENES, GENETIC polymorphisms, MEDICAL cooperation, RACE, RESEARCH, RESEARCH funding, RISK assessment, GENOMICS, DATA analysis, GENETICS
Abstract

Background: Isolated, nonsyndromic cleft lip with or without cleft palate is a common human congenital malformation with a complex and heterogeneous etiology. Genes coding for fibroblast growth factors and their receptors (FGF/FGFR genes) are excellent candidate genes. Methods: We tested single-nucleotide polymorphic markers in 10 FGFIFGFR genes (including FGFBP1, FGF2, FGF1O, FGFI8, FGFR1, FGFR2, FGFI9, FGF4, FGF3, and FGF9) for genotypic effects, interactions with one another, and with common maternal environmental exposures in 221 Asian and 76 Maryland case-parent trios ascertained through a child with isolated, nonsyndromic cleft lip with or without cleft palate. Results: Both FGFR1 and FGF19 yielded evidence of linkage and association in the transmission disequilibrium test, confirming previous evidence. Haplotypes of three single-nucleotide polymorphisms in FGFRI were nominally significant among Asian trios. Estimated odds ratios for individual single-nucleotide polymorphic markers and haplotypes of multiple markers in FGF19 ranged from 1.31 to 1.87. We also found suggestive evidence of maternal genotypic effects for markers in FGF2 and FGF1O among Asian trios. Tests for gene-environment (G x E) interaction between markers in FGFR2 and maternal smoking or multivitamin supplementation yielded significant evidence of G X E interaction separately. Tests of gene-gene (G x G) interaction using Cordell's method yielded significant evidence between single-nucleotide polymorphisms in FGF9 and FGF18, which was confirmed in an independent sample of trios from an international consortium. Conclusion: Our results suggest several genes in the FGFIFGFR family may influence risk for isolated, nonsyndromic cleft lip with or without cleft palate through distinct biological mechanisms. [ABSTRACT FROM AUTHOR]

Published
2013
Full Text
View/download PDF

31. The FGFand FGFRGene Family and Risk of Cleft Lip with or Without Cleft Palate

Author

Wang, Hong, Zhang, Tianxiao, Wu, Tao, Hetmanski, Jacqueline B., Ruczinski, Ingo, Schwender, Holger, Yee Liang, Kung, Murray, Tanda, Daniele Fallin, M., Redett, Richard J., Raymond, Gerald V., Jin, Sheng-Chih, Wu Chou, Yah-Huei, Kuo-Ting Chen, Philip, Yeow, Vincent, Chong, Samuel S., Cheah, Felicia S.H., Ha Jee, Sun, Jabs, Ethylin W., Scott, Alan F., and Beaty, Terri H.

Abstract

Background Isolated, nonsyndromic cleft lip with or without cleft palate is a common human congenital malformation with a complex and heterogeneous etiology. Genes coding for fibroblast growth factors and their receptors (FGF/FGFRgenes) are excellent candidate genes.Methods We tested single-nucleotide polymorphic markers in 10 FGF/FGFRgenes (including FGFBP1, FGF2, FGF10, FGF18, FGFR1, FGFR2, FGF19, FGF4, FGF3, and FGF9)for genotypic effects, interactions with one another, and with common maternal environmental exposures in 221 Asian and 76 Maryland case-parent trios ascertained through a child with isolated, nonsyndromic cleft lip with or without cleft palate.Results Both FGFR1and FGF19yielded evidence of linkage and association in the transmission disequilibrium test, confirming previous evidence. Haplotypes of three single-nucleotide polymorphisms in FGFR1were nominally significant among Asian trios. Estimated odds ratios for individual single-nucleotide polymorphic markers and haplotypes of multiple markers in FGF19ranged from 1.31 to 1.87. We also found suggestive evidence of maternal genotypic effects for markers in FGF2and FGF10among Asian trios. Tests for gene-environment (G x E) interaction between markers in FGFR2and maternal smoking or multivitamin supplementation yielded significant evidence of G x E interaction separately. Tests of gene-gene (G x G) interaction using Cordell's method yielded significant evidence between single-nucleotide polymorphisms in FGF9and FGF18, which was confirmed in an independent sample of trios from an international consortium.Conclusion Our results suggest several genes in the FGF/FGFRfamily may influence risk for isolated, nonsyndromic cleft lip with or without cleft palate through distinct biological mechanisms.

Published
2013
Full Text
View/download PDF

32. Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.

Author

Stephens SH, Hartz SM, Hoft NR, Saccone NL, Corley RC, Hewitt JK, Hopfer CJ, Breslau N, Coon H, Chen X, Ducci F, Dueker N, Franceschini N, Frank J, Han Y, Hansel NN, Jiang C, Korhonen T, Lind PA, Liu J, Lyytikäinen LP, Michel M, Shaffer JR, Short SE, Sun J, Teumer A, Thompson JR, Vogelzangs N, Vink JM, Wenzlaff A, Wheeler W, Yang BZ, Aggen SH, Balmforth AJ, Baumeister SE, Beaty TH, Benjamin DJ, Bergen AW, Broms U, Cesarini D, Chatterjee N, Chen J, Cheng YC, Cichon S, Couper D, Cucca F, Dick D, Foroud T, Furberg H, Giegling I, Gillespie NA, Gu F, Hall AS, Hällfors J, Han S, Hartmann AM, Heikkilä K, Hickie IB, Hottenga JJ, Jousilahti P, Kaakinen M, Kähönen M, Koellinger PD, Kittner S, Konte B, Landi MT, Laatikainen T, Leppert M, Levy SM, Mathias RA, McNeil DW, Medland SE, Montgomery GW, Murray T, Nauck M, North KE, Paré PD, Pergadia M, Ruczinski I, Salomaa V, Viikari J, Willemsen G, Barnes KC, Boerwinkle E, Boomsma DI, Caporaso N, Edenberg HJ, Francks C, Gelernter J, Grabe HJ, Hops H, Jarvelin MR, Johannesson M, Kendler KS, Lehtimäki T, Magnusson PK, Marazita ML, Marchini J, Mitchell BD, Nöthen MM, Penninx BW, Raitakari O, Rietschel M, Rujescu D, Samani NJ, Schwartz AG, Shete S, Spitz M, Swan GE, Völzke H, Veijola J, Wei Q, Amos C, Cannon DS, Grucza R, Hatsukami D, Heath A, Johnson EO, Kaprio J, Madden P, Martin NG, Stevens VL, Weiss RB, Kraft P, Bierut LJ, and Ehringer MA

Subjects
Adolescent, Age of Onset, Cotinine metabolism, Female, Genetic Loci genetics, Humans, Internationality, Linkage Disequilibrium genetics, Male, Nerve Tissue Proteins genetics, Phenotype, Tobacco Use Disorder genetics, Genetic Predisposition to Disease, Multigene Family genetics, Polymorphism, Single Nucleotide genetics, Receptors, Nicotinic genetics, Smoking genetics
Abstract

Neuronal nicotinic acetylcholine receptor (nAChR) genes (CHRNA5/CHRNA3/CHRNB4) have been reproducibly associated with nicotine dependence, smoking behaviors, and lung cancer risk. Of the few reports that have focused on early smoking behaviors, association results have been mixed. This meta-analysis examines early smoking phenotypes and SNPs in the gene cluster to determine: (1) whether the most robust association signal in this region (rs16969968) for other smoking behaviors is also associated with early behaviors, and/or (2) if additional statistically independent signals are important in early smoking. We focused on two phenotypes: age of tobacco initiation (AOI) and age of first regular tobacco use (AOS). This study included 56,034 subjects (41 groups) spanning nine countries and evaluated five SNPs including rs1948, rs16969968, rs578776, rs588765, and rs684513. Each dataset was analyzed using a centrally generated script. Meta-analyses were conducted from summary statistics. AOS yielded significant associations with SNPs rs578776 (beta = 0.02, P = 0.004), rs1948 (beta = 0.023, P = 0.018), and rs684513 (beta = 0.032, P = 0.017), indicating protective effects. There were no significant associations for the AOI phenotype. Importantly, rs16969968, the most replicated signal in this region for nicotine dependence, cigarettes per day, and cotinine levels, was not associated with AOI (P = 0.59) or AOS (P = 0.92). These results provide important insight into the complexity of smoking behavior phenotypes, and suggest that association signals in the CHRNA5/A3/B4 gene cluster affecting early smoking behaviors may be different from those affecting the mature nicotine dependence phenotype., (© 2013 WILEY PERIODICALS, INC.)

Published
2013
Full Text
View/download PDF

33. The FGF and FGFR Gene Family and Risk of Cleft Lip With or Without Cleft Palate.

Author

Wang H, Zhang T, Wu T, Hetmanski JB, Ruczinski I, Schwender H, Liang KY, Murray T, Fallin MD, Redett RJ, Raymond GV, Jin SC, Chou YH, Chen PK, Yeow V, Chong SS, Cheah FS, Jee SH, Jabs EW, Scott AF, and Beaty TH

Subjects
Haplotypes, Humans, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Cleft Lip genetics, Cleft Palate
Abstract

Background : Isolated, nonsyndromic cleft lip with or without cleft palate is a common human congenital malformation with a complex and heterogeneous etiology. Genes coding for fibroblast growth factors and their receptors (FGF/FGFR genes) are excellent candidate genes. Methods : We tested single-nucleotide polymorphic markers in 10 FGF/FGFR genes (including FGFBP1, FGF2, FGF10, FGF18, FGFR1, FGFR2, FGF19, FGF4, FGF3, and FGF9) for genotypic effects, interactions with one another, and with common maternal environmental exposures in 221 Asian and 76 Maryland case-parent trios ascertained through a child with isolated, nonsyndromic cleft lip with or without cleft palate. Results : Both FGFR1 and FGF19 yielded evidence of linkage and association in the transmission disequilibrium test, confirming previous evidence. Haplotypes of three single-nucleotide polymorphisms in FGFR1 were nominally significant among Asian trios. Estimated odds ratios for individual single-nucleotide polymorphic markers and haplotypes of multiple markers in FGF19 ranged from 1.31 to 1.87. We also found suggestive evidence of maternal genotypic effects for markers in FGF2 and FGF10 among Asian trios. Tests for gene-environment (G × E) interaction between markers in FGFR2 and maternal smoking or multivitamin supplementation yielded significant evidence of G × E interaction separately. Tests of gene-gene (G × G) interaction using Cordell's method yielded significant evidence between single-nucleotide polymorphisms in FGF9 and FGF18, which was confirmed in an independent sample of trios from an international consortium. Conclusion : Our results suggest several genes in the FGF/FGFR family may influence risk for isolated, nonsyndromic cleft lip with or without cleft palate through distinct biological mechanisms.

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results