15,525 results on '"Murray, R."'
Search Results
2. Island change framework defines dominant modes of atoll island dynamics in response to environmental change
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Paul S. Kench, Meghna Sengupta, Murray R. Ford, and Susan D. Owen
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Geology ,QE1-996.5 ,Environmental sciences ,GE1-350 - Abstract
Abstract Climatic change threatens the persistence of atoll islands and the cultural and ecosystem services they support. However, adaptation and ecosystem management are constrained by lack of knowledge of island-specific transformations. We present an empirically-based island change framework that characterises the physical trajectory of islands, based on high-resolution shoreline analysis on 509 atoll islands in the central Pacific over the past half-century. Using changes in island size and position we identify seven distinct styles of island transformation in the Pacific, including contraction (21.4%), stability (46.1%) and expansion (32.4%), and show that 40% of islands are currently mobile on reef surfaces. Results challenge the framing of islands as erosional, which misrepresents island behaviour and constrains understanding of island futures. The island change framework highlights a broader set of island-specific management considerations, and opportunities, that scale with the style and rate of island change, and provides an empirical basis to inform management.
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- 2024
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3. Island change framework defines dominant modes of atoll island dynamics in response to environmental change
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Kench, Paul S., Sengupta, Meghna, Ford, Murray R., and Owen, Susan D.
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- 2024
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4. Reflections on the 2023 AMR Decade Award: Revisions and Extensions of the Theory of Purposeful Work Behavior.
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Barrick, Murray R., Mount, Michael K., and Li, Ning
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JOB performance ,EMPLOYEE motivation ,GOAL (Psychology) ,EMPLOYEE attitudes ,PERSONALITY & occupation ,WORK environment ,CORPORATE culture - Abstract
We are gratified by the response to our 2013 article introducing the theory of purposeful work behavior (TPWB; Barrick, Mount & Li, 2013). This reflective essay expands the TPWB by incorporating recent research on personal attributes and workplace characteristics that motivate purposeful goal striving. We clarify that personality traits, career interests, and personal values represent key internal motivational forces, while job design, leadership styles, and organizational culture reflect critical external motivational forces jointly influencing purposeful goal strivings. A central revision specifies whether personal attributes and workplace characteristics interact in a substitutive or synergistic pattern, depending on whether the purposeful striving is self-driven (achievement, status) or other-driven (communion, autonomy). We describe how experienced meaningfulness uniquely manifests across the four motivational pathways, leading to differentiable attitudinal and behavioral outcomes. Additionally, we recognize feedback processes whereby goal progress reinforces future purposeful striving and experienced meaningfulness. The updated TPWB explains how personal and workplace motivational forces can attenuate each other's effects or act as substitutes in driving purposeful goal pursuit. It also accounts for situations where these forces interact synergistically, amplifying purposeful goal striving. In turn, this energizes purposeful work behavior through experienced meaningfulness, enabling individuals to "do well" behaviorally and "feel well" attitudinally. [ABSTRACT FROM AUTHOR]
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- 2024
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5. A new classification of algebraic identities for linear operators on associative algebras
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Bremner, Murray R. and Elgendy, Hader A.
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Mathematics - Rings and Algebras ,Mathematics - Operator Algebras ,Primary 47C05. Secondary 13P10, 13P15, 17B38, 18M70, 39B42, 47-08 - Abstract
We introduce a new approach to the classification of operator identities, based on basic concepts from the theory of algebraic operads together with computational commutative algebra applied to determinantal ideals of matrices over polynomial rings. We consider operator identities of degree 2 (the number of variables in each term) and multiplicity 1 or 2 (the number of operators in each term), but our methods apply more generally. Given an operator identity with indeterminate coefficients, we use partial compositions to construct a matrix of consequences, and then use computer algebra to determine the values of the indeterminates for which this matrix has submaximal rank. For multiplicity 1 we obtain six identities, including the derivation identity. For multiplicity 2 we obtain eighteen identities and two parametrized families, including the left and right averaging identities, the Rota-Baxter identity, the Nijenhuis identity, and some new identities which deserve further study., Comment: 20 pages
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- 2021
6. Patient Experiences of Patient–Clinician Communication Among Cancer Multidisciplinary Healthcare Professionals During “Breaking Bad News”: A Qualitative Systematic Review
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Primeau, Charlotte, Chau, Minh, Turner, Murray R, and Paterson, Catherine
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- 2024
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7. Higher Polynomial Identities for Mutations of Associative Algebras
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Bremner, Murray R., Brox, Jose, and Sánchez-Ortega, Juana
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- 2023
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8. Dynamic changes of the Prf/Pto tomato resistance complex following effector recognition
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Sheikh, Arsheed H., Zacharia, Iosif, Pardal, Alonso J., Dominguez-Ferreras, Ana, Sueldo, Daniela J., Kim, Jung-Gun, Balmuth, Alexi, Gutierrez, Jose R., Conlan, Brendon F., Ullah, Najeeb, Nippe, Olivia M., Girija, Anil M., Wu, Chih-Hang, Sessa, Guido, Jones, Alexandra M. E., Grant, Murray R., Gifford, Miriam L., Mudgett, Mary Beth, Rathjen, John P., and Ntoukakis, Vardis
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- 2023
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9. Comparing Example-Based Collaborative Reflection to Problem Solving Practice for Learning during Team-Based Software Engineering Projects
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Sankaranarayanan, Sreecharan, Kandimalla, Siddharth Reddy, Bogart, Christopher, Murray, R. Charles, An, Haokang, Hilton, Michael, Sakr, Majd, and Rosé, Carolyn
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Computer Science - Software Engineering - Abstract
Contributing to the literature on aptitude-treatment interactions between worked examples and problem-solving, this paper addresses differential learning from the two approaches when students are positioned as domain experts learning new concepts. Our evaluation is situated in a team project that is part of an advanced software engineering course. In this course, students who possess foundational domain knowledge but are learning new concepts engage alternatively in programming followed by worked example-based reflection. They are either allowed to finish programming or are curtailed after a pre-specified time to participate in a longer worked example-based reflection. We find significant pre- to post-test learning gains in both conditions. Then, we not only find significantly more learning when students participated in longer worked example-based reflections but also a significant performance improvement on a problem-solving transfer task. These findings suggest that domain experts learning new concepts benefit more from worked example-based reflections than from problem-solving., Comment: 4 pages, 1 image, 1 table, 14th Computer Supported Collaborative Learning (CSCL) Proceedings at the Annual Meeting of the International Society of the Learning Sciences (ISLS)
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- 2021
10. Adult Severe Asthma Registries: A Global and Growing Inventory
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Cushen B, Koh MS, Tran TN, Martin N, Murray R, Uthaman T, Goh CYY, Vella R, Eleangovan N, Bulathsinhala L, Maspero JF, Peters MJ, Schleich F, Pitrez P, Christoff G, Sadatsafavi M, Torres-Duque CA, Porsbjerg C, Altraja A, Lehtimäki L, Bourdin A, Taube C, Papadopoulos NG, Zsuzsanna C, Björnsdóttir U, Salvi S, Heffler E, Iwanaga T, al-Ahmad M, Larenas-Linnemann D, van Boven JF, Aarli BB, Kuna P, Loureiro CC, Al-lehebi R, Lee JH, Marina N, Bjermer L, Sheu CC, Mahboub B, Busby J, Menzies-Gow A, Wang E, and Price DB
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asia-pacific ,biologics ,covid-19 ,europe ,isar ,international severe asthma registry ,oral corticosteroids ,registry ,middle east ,severe asthma ,latin america ,usa ,Medicine - Abstract
Breda Cushen,1,* Mariko Siyue Koh,2,* Trung N Tran,3 Neil Martin,3,4 Ruth Murray,5 Thendral Uthaman,6 Celine Yun Yi Goh,5,6 Rebecca Vella,7 Neva Eleangovan,5,6 Lakmini Bulathsinhala,5,6 Jorge F Maspero,8,9 Matthew J Peters,10 Florence Schleich,11 Paulo Pitrez,12 George Christoff,13 Mohsen Sadatsafavi,14 Carlos A Torres-Duque,15,16 Celeste Porsbjerg,17 Alan Altraja,18 Lauri Lehtimäki,19 Arnaud Bourdin,20 Christian Taube,21 Nikolaos G Papadopoulos,22,23 Csoma Zsuzsanna,24 Unnur Björnsdóttir,25 Sundeep Salvi,26 Enrico Heffler,27 Takashi Iwanaga,28 Mona al-Ahmad,29 Désirée Larenas-Linnemann,30 Job FM van Boven,31 Bernt Bøgvald Aarli,32,33 Piotr Kuna,34 Cláudia Chaves Loureiro,35,36 Riyad Al-lehebi,37 Jae Ha Lee,38 Nuria Marina,39 Leif Bjermer,40 Chau-Chyun Sheu,41,42 Bassam Mahboub,43 John Busby,44 Andrew Menzies-Gow,45 Eileen Wang,46 David B Price5,6,47 On behalf of ISAR Inventory Study Group1Department of Respiratory Medicine, Beaumont Hospital, Dublin, Ireland; 2Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore, Singapore; 3AstraZeneca, Gaithersburg, MD, USA; 4Department of Respiratory Medicine, University of Leicester, Leicester, UK; 5Optimum Patient Care Global, Cambridge, UK; 6Observational Pragmatic Research Institute, Singapore, Singapore; 7Optimum Patient Care, Brisbane, Queensland, Australia; 8Clinical Research for Allergy and Respiratory Medicine, CIDEA Foundation, Buenos Aires, Argentina; 9University Career of Specialists in Allergy and Clinical Immunology at the Buenos Aires University School of Medicine, Buenos Aires, Argentina; 10Department of Thoracic Medicine, Concord Hospital, Sydney, Australia; 11CHU Sart-Tilman, GIGA I3, University of Liege, Liège, Wallonia, Belgium; 12Pulmonology Division, Hospital Santa Casa de Porto Alegre, Porto Alegre, Brazil; 13Faculty of Public Health, Medical University, Sofia, Bulgaria; 14Respiratory Evaluation Sciences Program, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Canada; 15CINEUMO, Respiratory Research Center, Fundación Neumológica Colombiana, Bogotá, Colombia; 16Universidad de La Sabana, Chia, Colombia; 17Department of Respiratory Medicine and Infectious Diseases, Research Unit, Bispebjerg Hospital, Copenhagen, Denmark; 18Department of Pulmonology, University of Tartu and Lung Clinic, Tartu University Hospital, Tartu, Estonia; 19Allergy Centre, Tampere University Hospital, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; 20PhyMedExp, Univ Montpellier, CNRS, INSERM, CHU Montpellier, Montpellier, France; 21Department of Pulmonary Medicine, University Medical Center Essen-Ruhrlandklinik, Essen, Germany; 22Division of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester, UK; 23Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece; 24Asthma Outpatient Clinic, National Koranyi Institute for Pulmonology, Budapest, Hungary; 25Department of Allergy and Respiratory Medicine, University Hospital, Reykjavik, Iceland; 26Pulmocare Research and Education Foundation, Pune, India; 27Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy; 28Kindai University Hospital, Osakasayama, Japan; 29Microbiology Department, College of Medicine, Kuwait University, Kuwait, Al-Rashed Allergy Center, Ministry of Health, Kuwait City, Kuwait; 30Centro de Excelencia en Asma y Alergia, Hospital Médica Sur, Ciudad de México, Mexico; 31University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Department of Clinical Pharmacy & Pharmacology, Groningen, the Netherlands; 32Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway; 33Department of Clinical Science, University of Bergen, Bergen, Norway; 34Division of Internal Medicine Asthma and Allergy, Medical University of Lodz, Lodz, Poland; 35Pneumology Unit, Hospitais da Universidade de Coimbra, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; 36Centre of Pneumology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal; 37Department of Pulmonology, King Fahad Medical City, Riyadh, Saudi Arabia, Alfaisal University, Riyadh, Saudi Arabia; 38Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea; 39Pneumology Service, Biocruces, Cruces University Hospital, Barakaldo, Spain; 40Respiratory Medicine and Allergology, Department of Clinical Sciences, Skåne University Hospital, Lund University, Lund, Sweden; 41Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; 42Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 43Rashid Hospital, Dubai Health Authority (DHA), Dubai, United Arab Emirates; 44Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast, Northern Ireland, UK; 45Lung Division, Royal Brompton & Harefield Hospital, London, UK; 46Division of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health and University of Colorado School of Medicine, Denver and Aurora, CO, USA; 47Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, Scotland, UK*These authors contributed equally to this workCorrespondence: David B Price, Observational and Pragmatic Research Institute (OPRI) Pte Ltd, 22 Sin Ming Lane, #06-76, Midview City, 573969, Singapore, Tel +65 3105 1489, Email dprice@opri.sgAim: The International Severe Asthma Registry (ISAR; http://isaregistries.org/) uses standardised variables to enable multi-country and adequately powered research in severe asthma. This study aims to look at the data countries within ISAR and non-ISAR countries reported collecting that enable global research that support individual country interests.Methods: Registries were identified by online searches and approaching severe asthma experts. Participating registries provided data collection specifications or confirmed variables collected. Core variables (results from ISAR’s Delphi study), steroid-related comorbidity variables, biologic safety variables (serious infection, anaphylaxis, and cancer), COVID-19 variables and additional variables (not belonging to the aforementioned categories) that registries reported collecting were summarised.Results: Of the 37 registries identified, 26 were ISAR affiliates and 11 non-ISAR affiliates. Twenty-five ISAR-registries and 4 non-ISAR registries reported collecting > 90% of the 65 core variables. Twenty-three registries reported collecting all optional steroid-related comorbidity variables. Twenty-nine registries reported collecting all optional safety variables. Ten registries reported collecting COVID-19 variables. Twenty-four registries reported collecting additional variables including data from asthma questionnaires (10 Asthma Control Questionnaire, 20 Asthma Control Test, 11 Asthma Quality of Life Questionnaire, and 4 EuroQol 5-dimension 5-level Questionnaire). Eight registries are linked to databases such as electronic medical records and national claims or disease databases.Conclusion: Standardised data collection has enabled individual severe asthma registries to collect unified data and increase statistical power for severe asthma research irrespective of ISAR affiliations.Keywords: Asia-Pacific, biologics, COVID-19, Europe, ISAR, International Severe Asthma Registry, oral corticosteroids, Registry, Middle East, Severe Asthma, Latin America, USA
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- 2023
11. Synthetic asphaltene for green carbon material
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Morimoto, Masato, Scott, David E., Hamilton, Robin J., Stryker, Jeffrey M., Tykwinski, Rik R., and Gray, Murray R.
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- 2024
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12. Wind turbine contaminant classification using machine learning techniques
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Cummins, S., Campbell, J.N., Durkan, S.M., Somers, J., Finnegan, W., Goggins, J., Hayden, P., Murray, R., Burke, D., Lally, C., Alli, M.B., Varvarezos, L., and Costello, J.T.
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- 2023
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13. Dynamic changes of the Prf/Pto tomato resistance complex following effector recognition
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Arsheed H. Sheikh, Iosif Zacharia, Alonso J. Pardal, Ana Dominguez-Ferreras, Daniela J. Sueldo, Jung-Gun Kim, Alexi Balmuth, Jose R. Gutierrez, Brendon F. Conlan, Najeeb Ullah, Olivia M. Nippe, Anil M. Girija, Chih-Hang Wu, Guido Sessa, Alexandra M. E. Jones, Murray R. Grant, Miriam L. Gifford, Mary Beth Mudgett, John P. Rathjen, and Vardis Ntoukakis
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Science - Abstract
Abstract In both plants and animals, nucleotide-binding leucine-rich repeat (NLR) immune receptors play critical roles in pathogen recognition and activation of innate immunity. In plants, NLRs recognise pathogen-derived effector proteins and initiate effector-triggered immunity (ETI). However, the molecular mechanisms that link NLR-mediated effector recognition and downstream signalling are not fully understood. By exploiting the well-characterised tomato Prf/Pto NLR resistance complex, we identified the 14-3-3 proteins TFT1 and TFT3 as interacting partners of both the NLR complex and the protein kinase MAPKKKα. Moreover, we identified the helper NRC proteins (NLR-required for cell death) as integral components of the Prf /Pto NLR recognition complex. Notably our studies revealed that TFTs and NRCs interact with distinct modules of the NLR complex and, following effector recognition, dissociate facilitating downstream signalling. Thus, our data provide a mechanistic link between activation of immune receptors and initiation of downstream signalling cascades.
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- 2023
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14. Use of Remote Cardiorespiratory Monitoring is Associated with a Reduction in Hospitalizations for Subjects with COPD
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Polsky M, Moraveji N, Hendricks A, Teresi RK, Murray R, and Maselli DJ
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copd ,exacerbations ,hospitalizations ,admissions ,remote patient monitoring ,Diseases of the respiratory system ,RC705-779 - Abstract
Michael Polsky,1 Neema Moraveji,2 Ashley Hendricks,2 Robert K Teresi,2 Richard Murray,2 Diego J Maselli3 1Pulmonary Associates of Richmond, Richmond, VA, USA; 2Spire Health, San Francisco, CA, USA; 3Division of Pulmonary Diseases & Critical Care, UT Health, San Antonio, TX, USACorrespondence: Neema Moraveji, Spire Health, 555 De Haro St, San Francisco, CA, 94107, USA, Tel +1 415 533 2385, Email neema@spirehealth.comBackground: Chronic obstructive pulmonary disease (COPD) is prevalent and results in high healthcare resource utilization. The largest impact on health status and proportion of healthcare costs in COPD are related to hospitalizations for acute exacerbations. Accordingly, the Centers for Medicare & Medicaid Services have advocated for remote patient monitoring (RPM) to aid in chronic disease management. However, there has been a lack of evidence for the effectiveness of RPM in reducing the need for unplanned hospitalizations for patients with COPD.Methods: This pre/post study was a retrospective analysis of unplanned hospitalizations in a cohort of COPD subjects started on RPM at a large, outpatient pulmonary practice. The study included all subjects with at least one unplanned, all-cause hospitalization or emergency room visit in the prior year, who had elected to enroll in an RPM service for assistance with clinical management. Additional inclusion criteria included being on RPM for at least 12 months and a patient of the practice for at least two years (12 months pre- and post-initiation of RPM).Results: The study included 126 subjects. RPM was associated with a significantly lower rate of unplanned hospitalizations per patient per year (1.09 ± 0.07 versus 0.38 ± 0.06, P< 0.001).Conclusion: Unplanned, all-cause hospitalization rates were lower in subjects started on RPM for COPD when compared to their prior year. These results support the potential of RPM to improve the long-term management of COPD.Keywords: COPD, exacerbations, hospitalizations, admissions, remote patient monitoring, physiology
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- 2023
15. Helmholtz Decomposition of WP'S Vector Fields*
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Cantor, Murray R., primary and Matovsky, John C., additional
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- 2023
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16. Enumeration and Asymptotic Formulas for Rectangular Partitions of the Hypercube
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Au, Yu Hin, Bagherzadeh, Fatemeh, and Bremner, Murray R.
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Mathematics - Combinatorics ,Mathematics - K-Theory and Homology ,Mathematics - Rings and Algebras - Abstract
We study a two-parameter generalization of the Catalan numbers: $C_{d,p}(n)$ is the number of ways to subdivide the $d$-dimensional hypercube into $n$ rectangular blocks using orthogonal partitions of fixed arity $p$. Bremner \& Dotsenko introduced $C_{d,p}(n)$ in their work on Boardman--Vogt tensor products of operads; they used homological algebra to prove a recursive formula and a functional equation. We express $C_{d,p}(n)$ as simple finite sums, and determine their growth rate and asymptotic behaviour. We give an elementary proof of the functional equation, using a bijection between hypercube decompositions and a family of full $p$-ary trees. Our results generalize the well-known correspondence between Catalan numbers and full binary trees.
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- 2019
17. How large is the global living wage gap and the price increase needed to close it?
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Hall, Murray R and Suh, Sangwon
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living wage ,fair trade ,ethical trade ,social price formation ,social value ,globalization ,poverty reduction ,Anker's Method ,corporate social responsibility ,multiregional input-output analysis ,Leontief price model ,supply chain management ,Indian jeans ,Economics ,Political Science & Public Administration - Abstract
Abstract We estimated the global living wage gap (LWG) as $US674 billion per year, which is comparable to the gross domestic product (GDP) of Switzerland. India (IND), the largest LWG country, contributed 32% of the global LWG. For a pair of jeans, closing the gap increases low-skilled cotton and textile wages in IND by 137% and 52%, respectively, while the retail price would increase only by 8% if consumed in Western countries. However, we found that most of the outputs with large LWGs from low-income countries are consumed domestically, suggesting that (a) closing the gap significantly increases the domestic price of products such as agriculture and textiles in low-income countries; and that (b) living wage premiums in high-income countries alone have a limited impact on closing the global LWG. The results highlight the need for both ethical trade and domestic living wage initiatives to close global LWGs.
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- 2020
18. Higher polynomial identities for mutations of associative algebras
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Bremner, Murray R., Brox, Jose, and Sánchez-Ortega, Juana
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Mathematics - Rings and Algebras ,Primary 18M70, Secondary 16R10, 16W10, 17A30, 17A50, 17B60, 17C65, 17D25, 68W30 - Abstract
We study polynomial identities satisfied by the mutation product $xpy - yqx$ on the underlying vector space of an associative algebra $A$, where $p, q$ are fixed elements of $A$. We simplify known results for identities in degree $4$, proving that only two identities are necessary and sufficient to generate them all; in degree 5, we show that adding one new identity suffices; in degree 6, we demonstrate the existence of a number of new identities., Comment: 12 pages, 3 figures. The new version has a new coauthor and some improvements
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- 2018
19. Phylogenomic Analysis Supports the Transfer of 20 Pathovars from Xanthomonas campestris into Xanthomonas euvesicatoria
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Jamie Harrison, Rana M. F. Hussain, Andrew Aspin, Murray R. Grant, Joana G. Vicente, and David J. Studholme
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Xanthomonas campestris ,pathovars ,Xanthomonas euvesicatoria ,Biology (General) ,QH301-705.5 - Abstract
The Gram-negative bacterial genus Xanthomonas includes numerous infra-specific taxa known as pathovars, which are defined primarily on host range and disease symptoms. With the advent of molecular sequence data, many pathovars have been transferred from X. campestris into other Xanthomonas species to better harmonise taxonomy and phylogeny. We performed whole-genome shotgun sequencing on pathotype strains of the following X. campestris pathovars: blepharidis, carissae, clerodendri, convolvuli, coriandri, daturae, euphorbiae, fici, heliotropii, ionidii, lawsoniae, mirabilis, obscurae, paulliniae, pennamericanum, spermacoces, uppalii, vernoniae, viegasii and zingibericola. These genomes showed more than 98% average nucleotide identity with the type-strain of X. euvesicatoria and less than 88% with the type-strain of X. campestris. We propose the transfer of these pathovars into X. euvesicatoria and present an emended species description for X. euvesicatoria.
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- 2023
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20. Special Identities for Comtrans Algebras
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Bremner, Murray R. and Elgendy, Hader A.
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Mathematics - Rings and Algebras ,Mathematics - Representation Theory ,17A40 (Primary), 15-04, 15A21, 15A69, 15B36, 18D50, 20C30, 68W30 (Secondary) - Abstract
Comtrans algebras, arising in web geometry, have two trilinear operations, commutator and translator. We determine a Gr\"obner basis for the comtrans operad, and state a conjecture on its dimension formula. We study multilinear polynomial identities for the special commutator $[x,y,z] = xyz-yxz$ and special translator $\langle x, y, z \rangle = xyz-yzx$ in associative triple systems. In degree 3, the defining identities for comtrans algebras generate all identities. In degree 5, we simplify known identities for each operation and determine new identities relating the operations. In degree 7, we use representation theory of the symmetric group to show that each operation satisfies identities which do not follow from those of lower degree but there are no new identities relating the operations. We use noncommutative Gr\"obner bases to construct the universal associative envelope for the special comtrans algebra of $2 \times 2$ matrices., Comment: 18 pages, 4 figures. Sections 3.2 and 3.3 have been rewritten to emphasize the importance of the forgetful functor from symmetric operads to shuffle operads
- Published
- 2018
21. Symmetrization of Jordan dialgebras
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Bremner, Murray R.
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Mathematics - Rings and Algebras ,Mathematics - Representation Theory ,17A30 (Primary) 16W10, 17A50, 17C05, 17C50, 18D50, 68W30 (Secondary) - Abstract
A basic problem for any class of nonassociative algebras is to determine the polynomial identities satisfied by the symmetrization and the skew-symmetrization of the original product. We consider the symmetrization of the product in the class of special Jordan dialgebras. We use computational linear algebra to show that every polynomial identity of degree $n \le 5$ satisfied by the symmetrized Jordan diproduct in every diassociative algebra is a consequence of commutativity. We determine a complete set of generators for the polynomial identities in degree 6 which are not consequences of commutativity. We use a constructive version of the representation theory of the symmetric group to show that there exist further new identities in degree 7., Comment: 12 pages, 8 figures
- Published
- 2018
22. Heightened storm activity drives late Holocene reef island formation in the central Pacific Ocean
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Kench, Paul S., Ford, Murray R., Bramante, James F., Ashton, Andrew D., Donnelly, Jeffrey P., Sullivan, Richard M., and Toomey, Michael R.
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- 2022
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23. Evaluation of prognostic risk models for postoperative pulmonary complications in adult patients undergoing major abdominal surgery: a systematic review and international external validation cohort study
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Kouli, O, Murray, V, Bhatia, S, Cambridge, WA, Kawka, M, Shafi, S, Knight, SR, Kamarajah, SK, McLean, KA, Glasbey, JC, Khaw, RA, Ahmed, W, Akhbari, M, Baker, D, Borakati, A, Mills, E, Thavayogan, R, Yasin, I, Raubenheimer, K, Ridley, W, Sarrami, M, Zhang, G, Egoroff, N, Pockney, P, Richards, T, Bhangu, A, Creagh-Brown, B, Edwards, M, Harrison, EM, Lee, M, Nepogodiev, D, Pinkney, T, Pearse, R, Smart, N, Vohra, R, Sohrabi, C, Jamieson, A, Nguyen, M, Rahman, A, English, C, Tincknell, L, Kakodkar, P, Kwek, I, Punjabi, N, Burns, J, Varghese, S, Erotocritou, M, McGuckin, S, Vayalapra, S, Dominguez, E, Moneim, J, Salehi, M, Tan, HL, Yoong, A, Zhu, L, Seale, B, Nowinka, Z, Patel, N, Chrisp, B, Harris, J, Maleyko, I, Muneeb, F, Gough, M, James, CE, Skan, O, Chowdhury, A, Rebuffa, N, Khan, H, Down, B, Fatimah Hussain, Q, Adams, M, Bailey, A, Cullen, G, Fu, YXJ, McClement, B, Taylor, A, Aitken, S, Bachelet, B, Brousse de Gersigny, J, Chang, C, Khehra, B, Lahoud, N, Lee Solano, M, Louca, M, Rozenbroek, P, Rozitis, E, Agbinya, N, Anderson, E, Arwi, G, Barry, I, Batchelor, C, Chong, T, Choo, LY, Clark, L, Daniels, M, Goh, J, Handa, A, Hanna, J, Huynh, L, Jeon, A, Kanbour, A, Lee, A, Lee, J, Lee, T, Leigh, J, Ly, D, McGregor, F, Moss, J, Nejatian, M, O'Loughlin, E, Ramos, I, Sanchez, B, Shrivathsa, A, Sincari, A, Sobhi, S, Swart, R, Trimboli, J, Wignall, P, Bourke, E, Chong, A, Clayton, S, Dawson, A, Hardy, E, Iqbal, R, Le, L, Mao, S, Marinelli, I, Metcalfe, H, Panicker, D, R, HH, Ridgway, S, Tan, HH, Thong, S, Van, M, Woon, S, Woon-Shoo-Tong, XS, Yu, S, Ali, K, Chee, J, Chiu, C, Chow, YW, Duller, A, Nagappan, P, Ng, S, Selvanathan, M, Sheridan, C, Temple, M, Do, JE, Dudi-Venkata, NN, Humphries, E, Li, L, Mansour, LT, Massy-Westropp, C, Fang, B, Farbood, K, Hong, H, Huang, Y, Joan, M, Koh, C, Liu, YHA, Mahajan, T, Muller, E, Park, R, Tanudisastro, M, Wu, JJG, Chopra, P, Giang, S, Radcliffe, S, Thach, P, Wallace, D, Wilkes, A, Chinta, SH, Li, J, Phan, J, Rahman, F, Segaran, 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Aghanenu, O, Budd, W, Hayre, J, Khanom, S, Liew, ZY, McKinney, R, Moody, N, Muhammad-Kamal, H, Odogwu, J, Patel, D, Roy, C, Sattar, Z, Shahrokhi, N, Sinha, I, Thomson, E, Wonga, L, Bain, J, Khan, J, Ricardo, D, Bevis, R, Cherry, C, Darkwa, S, Drew, W, Griffiths, E, Konda, N, Madani, D, Mak, JKC, Meda, B, Odunukwe, U, Preest, G, Raheel, F, Rajaseharan, A, Ramgopal, A, Risbrooke, C, Selvaratnam, K, Sethunath, G, Tabassum, R, Taylor, J, Thakker, A, Wijesingha, N, Wybrew, R, Yasin, T, Ahmed Osman, A, Alfadhel, S, Carberry, E, Chen, JY, Drake, I, Glen, P, Jayasuriya, N, Kawar, L, Myatt, R, Sinan, LOH, Siu, SSY, Tjen, V, Adeboyejo, O, Bacon, H, Barnes, R, Birnie, C, D'Cunha Kamath, A, Hughes, E, Middleton, S, Owen, R, Schofield, E, Short, C, Smith, R, Wang, H, Willett, M, Zimmerman, M, Balfour, J, Chadwick, T, Coombe-Jones, M, Do Le, HP, Faulkner, G, Hobson, K, Shehata, Z, Beattie, M, Chmielewski, G, Chong, C, Donnelly, B, Drusch, B, Ellis, J, Farrelly, C, Feyi-Waboso, J, Hibell, I, Hoade, L, Ho, C, Jones, H, Kodiatt, B, Lidder, P, Ni Cheallaigh, L, Norman, R, Patabendi, I, Penfold, H, Playfair, M, Pomeroy, S, Ralph, C, Rottenburg, H, Sebastian, J, Sheehan, M, Stanley, V, Welchman, J, Ajdarpasic, D, Antypas, A, Azouaghe, O, Basi, S, Bettoli, G, Bhattarai, S, Bommireddy, L, Bourne, K, Budding, J, Cookey-Bresi, R, Cummins, T, Davies, G, Fabelurin, C, Gwilliam, R, Hanley, J, Hird, A, Kruczynska, A, Langhorne, B, Lund, J, Lutchman, I, McGuinness, R, Neary, M, Pampapathi, S, Pang, E, Podbicanin, S, Rai, N, Redhouse White, G, Sujith, J, Thomas, P, Walker, I, Winterton, R, Anderson, P, Barrington, M, Bhadra, K, Clark, G, Fowler, G, Gibson, C, Hudson, S, Kaminskaite, V, Lawday, S, Longshaw, A, MacKrill, E, McLachlan, F, Murdeshwar, A, Nieuwoudt, R, Parker, P, Randall, R, Rawlins, E, Reeves, SA, Rye, D, Sirkis, T, Sykes, B, Ventress, N, Wosinska, N, Akram, B, Burton, L, Coombs, A, Long, R, Magowan, D, Ong, C, Sethi, M, Williams, G, Chan, C, Chan, LH, Fernando, D, Gaba, F, Khor, Z, Les, JW, Mak, R, Moin, S, Ng Kee Kwong, KC, Paterson-Brown, S, Tew, YY, Bardon, A, Burrell, K, Coldwell, C, Costa, I, Dexter, E, Hardy, A, Khojani, M, Mazurek, J, Raymond, T, Reddy, V, Reynolds, J, Soma, A, Agiotakis, S, Alsusa, H, Desai, N, Peristerakis, I, Adcock, A, Ayub, H, Bennett, T, Bibi, F, Brenac, S, Chapman, T, Clarke, G, Clark, F, Galvin, C, Gwyn-Jones, A, Henry-Blake, C, Kerner, S, Kiandee, M, Lovett, A, Pilecka, A, Ravindran, R, Siddique, H, Sikand, T, Treadwell, K, Akmal, K, Apata, A, Barton, O, Broad, G, Darling, H, Dhuga, Y, Emms, L, Habib, S, Jain, R, Jeater, J, Kan, CYP, Kathiravelupillai, A, Khatkar, H, Kirmani, S, Kulasabanathan, K, Lacey, H, Lal, K, Manafa, C, Mansoor, M, McDonald, S, Mittal, A, Mustoe, S, Nottrodt, L, Oliver, P, Papapetrou, I, Pattinson, F, Raja, M, Reyhani, H, Shahmiri, A, Small, O, Soni, U, Aguirrezabala Armbruster, B, Bunni, J, Hakim, MA, Hawkins-Hooker, L, Howell, KA, Hullait, R, Jaskowska, A, Ottewell, L, Thomas-Jones, I, Vasudev, A, Clements, B, Fenton, J, Gill, M, Haider, S, Lim, AJM, Maguire, H, McMullan, J, Nicoletti, J, Samuel, S, Unais, MA, White, N, Yao, PC, Yow, L, Boyle, C, Brady, R, Cheekoty, P, Cheong, J, Chew, SJHL, Chow, R, Ganewatta Kankanamge, D, Mamer, L, Mohammed, B, Ng Chieng Hin, J, Renji Chungath, R, Royston, A, Sharrad, E, Sinclair, R, Tingle, S, Treherne, K, Wyatt, F, Maniarasu, VS, Moug, S, Appanna, T, Bucknall, T, Hussain, F, Owen, A, Parry, M, Parry, R, Sagua, N, Spofforth, K, Yuen, ECT, Bosley, N, Hardie, W, Moore, T, Regas, C, Abdel-Khaleq, S, Ali, N, Bashiti, H, Buxton-Hopley, R, Constantinides, M, D'Afflitto, M, Deshpande, A, Duque Golding, J, Frisira, E, Germani Batacchi, M, Gomaa, A, Hay, D, Hutchison, R, Iakovou, A, Iakovou, D, Ismail, E, Jefferson, S, Jones, L, Khouli, Y, Knowles, C, Mason, J, McCaughan, R, Moffatt, J, Morawala, A, Nadir, H, Neyroud, F, Nikookam, Y, Parmar, A, Pinto, L, Ramamoorthy, R, Richards, E, Thomson, S, Trainer, C, Valetopoulou, A, Vassiliou, A, Wantman, A, Wilde, S, Dickinson, M, Rockall, T, Senn, D, Wcislo, K, Zalmay, P, Adelekan, K, Allen, K, Bajaj, M, Gatumbu, P, Hang, S, Hashmi, Y, Kaur, T, Kawesha, A, Kisiel, A, Woodmass, M, Adelowo, T, Ahari, D, Alhwaishel, K, Atherton, R, Clayton, B, Cockroft, A, Curtis Lopez, C, Hilton, M, Ismail, N, Kouadria, M, Lee, L, MacConnachie, A, Monks, F, Mungroo, S, Nikoletopoulou, C, Pearce, L, Sara, X, Shahid, A, Suresh, G, Wilcha, R, Atiyah, A, Davies, E, Dermanis, A, Gibbons, H, Hyde, A, Lawson, A, Lee, C, Leung-Tack, M, Li Saw Hee, J, Mostafa, O, Nair, D, Pattani, N, Plumbley-Jones, J, Pufal, K, Ramesh, P, Sanghera, J, Saram, S, Scadding, S, See, S, Stringer, H, Torrance, A, Vardon, H, Wyn-Griffiths, F, Brew, A, Kaur, G, Soni, D, Tickle, A, Akbar, Z, Appleyard, T, Figg, K, Jayawardena, P, Johnson, A, Kamran Siddiqui, Z, Lacy-Colson, J, Oatham, R, Rowlands, B, Sludden, E, Turnbull, C, Allin, D, Ansar, Z, Azeez, Z, Dale, VH, Garg, J, Horner, A, Jones, S, Knight, S, McGregor, C, McKenna, J, McLelland, T, Packham-Smith, A, Rowsell, K, Spector-Hill, I, Adeniken, E, Baker, J, Bartlett, M, Chikomba, L, Connell, B, Deekonda, P, Dhar, M, Elmansouri, A, Gamage, K, Goodhew, R, Hanna, P, Knight, J, Luca, A, Maasoumi, N, Mahamoud, F, Manji, S, Marwaha, PK, Mason, F, Oluboyede, A, Pigott, L, Razaq, AM, Richardson, M, Saddaoui, I, Wijeyendram, P, Yau, S, Atkins, W, Liang, K, Miles, N, Praveen, B, Ashai, S, Braganza, J, Common, J, Cundy, A, Davies, R, Guthrie, J, Handa, I, Iqbal, M, Ismail, R, Jones, C, Jones, I, Lee, KS, Levene, A, Okocha, M, Olivier, J, Smith, A, Subramaniam, E, Tandle, S, Wang, A, Watson, A, Wilson, C, Chan, XHF, Khoo, E, Montgomery, C, Norris, M, Pugalenthi, PP, Common, T, Cook, E, Mistry, H, Shinmar, HS, Agarwal, G, Bandyopadhyay, S, Brazier, B, Carroll, L, Goede, A, Harbourne, A, Lakhani, A, Lami, M, Larwood, J, Martin, J, Merchant, J, Pattenden, S, Pradhan, A, Raafat, N, Rothwell, E, Shammoon, Y, Sudarshan, R, Vickers, E, Wingfield, L, Ashworth, I, Azizi, S, Bhate, R, Chowdhury, T, Christou, A, Davies, L, Dwaraknath, M, Farah, Y, Garner, J, Gureviciute, E, Hart, E, Jain, A, Javid, S, Kankam, HK, Kaur Toor, P, Kaz, R, Kermali, M, Khan, I, Mattson, A, McManus, A, Murphy, M, Nair, K, Ngemoh, D, Norton, E, Olabiran, A, Parry, L, Payne, T, Pillai, K, Price, S, Punjabi, K, Raghunathan, A, Ramwell, A, Raza, M, Ritehnia, J, Simpson, G, Smith, W, Sodeinde, S, Studd, L, Subramaniam, M, Thomas, J, Towey, S, Tsang, E, Tuteja, D, Vasani, J, Vio, M, Badran, A, Adams, J, Anthony Wilkinson, J, Asvandi, S, Austin, T, Bald, A, Bix, E, Carrick, M, Chander, B, Chowdhury, S, Cooper Drake, B, Crosbie, S, D Portela, S, Francis, D, Gallagher, C, Gillespie, R, Gravett, H, Gupta, P, Ilyas, C, James, G, Johny, J, Jones, A, Kinder, F, MacLeod, C, Macrow, C, Maqsood-Shah, A, Mather, J, McCann, L, McMahon, R, Mitham, E, Mohamed, M, Munton, E, Nightingale, K, O'Neill, K, Onyemuchara, I, Senior, R, Shanahan, A, Sherlock, J, Spyridoulias, A, Stavrou, C, Stokes, D, Tamang, R, Taylor, E, Trafford, C, Uden, C, Waddington, C, Yassin, D, Zaman, M, Bangi, S, Cheng, T, Chew, D, Hussain, N, Imani-Masouleh, S, Mahasivam, G, McKnight, G, Ng, HL, Ota, HC, Pasha, T, Ravindran, W, Shah, K, Vishnu K, S, Zaman, S, Carr, W, Cope, S, Eagles, EJ, Howarth-Maddison, M, Li, CY, Reed, J, Ridge, A, Stubbs, T, Teasdaled, D, Umar, R, Worthington, J, Dhebri, A, Kalenderov, R, Alattas, A, Arain, Z, Bhudia, R, Chia, D, Daniel, S, Dar, T, Garland, H, Girish, M, Hampson, A, Kyriacou, H, Lehovsky, K, Mullins, W, Omorphos, N, Vasdev, N, Venkatesh, A, Waldock, W, Bhandari, A, Brown, G, Choa, G, Eichenauer, CE, Ezennia, K, Kidwai, Z, Lloyd-Thomas, A, Macaskill Stewart, A, Massardi, C, Sinclair, E, Skajaa, N, Smith, M, Tan, I, Afsheen, N, Anuar, A, Azam, Z, Bhatia, P, Davies-kelly, N, Dickinson, S, Elkawafi, M, Ganapathy, M, Gupta, S, Khoury, EG, Licudi, D, Mehta, V, Neequaye, S, Nita, G, Tay, VL, Zhao, S, Botsa, E, Cuthbert, H, Elliott, J, Furlepa, M, Lehmann, J, Mangtani, A, Narayan, A, Nazarian, S, Parmar, C, Shah, D, Shaw, C, Zhao, Z, Beck, C, Caldwell, S, Clements, JM, French, B, Kenny, R, Kirk, S, Lindsay, J, McClung, A, McLaughlin, N, Watson, S, Whiteside, E, Alyacoubi, S, Arumugam, V, Beg, R, Dawas, K, Garg, S, Lloyd, ER, Mahfouz, Y, Manobharath, N, Moonesinghe, R, Morka, N, Patel, K, Prashar, J, Yip, S, Adeeko, ES, Ajekigbe, F, Bhat, A, Evans, C, Farrugia, A, Gurung, C, Long, T, Malik, B, Manirajan, S, Newport, D, Rayer, J, Ridha, A, Ross, E, Saran, T, Sinker, A, Waruingi, D, Allen, R, Al Sadek, Y, Alves do Canto Brum, H, Asharaf, H, Ashman, M, Balakumar, V, Barrington, J, Baskaran, R, Berry, A, Bhachoo, H, Bilal, A, Boaden, L, Chia, WL, Covell, G, Crook, D, Dadnam, F, Davis, L, De Berker, H, Doyle, C, Fox, C, Gruffydd-Davies, M, Hafouda, Y, Hill, A, Hubbard, E, Hunter, A, Inpadhas, V, Jamshaid, M, Jandu, G, Jeyanthi, M, Jones, T, Kantor, C, Kwak, SY, Malik, N, Matt, R, McNulty, P, Miles, C, Mohomed, A, Myat, P, Niharika, J, Nixon, A, O'Reilly, D, Parmar, K, Pengelly, S, Price, L, Ramsden, M, Turnor, R, Wales, E, Waring, H, Wu, M, Yang, T, Ye, TTS, Zander, A, Zeicu, C, Bellam, S, Francombe, J, Kawamoto, N, Rahman, MR, Sathyanarayana, A, Tang, HT, Cheung, J, Hollingshead, J, Page, V, Sugarman, J, Wong, E, Chiong, J, Fung, E, Kan, SY, Kiang, J, Kok, J, Krahelski, O, Liew, MY, Lyell, B, Sharif, Z, Speake, D, Alim, L, Amakye, NY, Chandrasekaran, J, Chandratreya, N, Drake, J, Owoso, T, Thu, YM, Abou El Ela Bourquin, B, Alberts, J, Chapman, D, Rehnnuma, N, Ainsworth, K, Carpenter, H, Emmanuel, T, Fisher, T, Gabrel, M, Guan, Z, Hollows, S, Hotouras, A, Ip Fung Chun, N, Jaffer, S, Kallikas, G, Kennedy, N, Lewinsohn, B, Liu, FY, Mohammed, S, Rutherfurd, A, Situ, T, Stammer, A, Taylor, F, Thin, N, Urgesi, E, Zhang, N, Ahmad, MA, Bishop, A, Bowes, A, Dixit, A, Glasson, R, Hatta, S, Hatt, K, Larcombe, S, Preece, J, Riordan, E, Fegredo, D, Haq, MZ, Li, C, McCann, G, Stewart, D, Baraza, W, Bhullar, D, Burt, G, Coyle, J, Deans, J, Devine, A, Hird, R, Ikotun, O, Manchip, G, Ross, C, Storey, L, Tan, WWL, Tse, C, Warner, C, Whitehead, M, Wu, F, Court, EL, Crisp, E, Huttman, M, Mayes, F, Robertson, H, Rosen, H, Sandberg, C, Smith, H, Al Bakry, M, Ashwell, W, Bajaj, S, Bandyopadhyay, D, Browlee, O, Burway, S, Chand, CP, Elsayeh, K, Elsharkawi, A, Evans, E, Ferrin, S, Fort-Schaale, A, Iacob, M, I, K, Impelliziere Licastro, G, Mankoo, AS, Olaniyan, T, Otun, J, Pereira, R, Reddy, R, Saeed, D, Simmonds, O, Singhal, G, Tron, K, Wickstone, C, Williams, R, Bradshaw, E, De Kock Jewell, V, Houlden, C, Knight, C, Metezai, H, Mirza-Davies, A, Seymour, Z, Spink, D, and Wischhusen, S
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- 2022
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24. Rubisco proton production can drive the elevation of CO₂ within condensates and carboxysomes
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Long, Benedict M., Förster, Britta, Pulsford, Sacha B., Price, G. Dean, and Badger, Murray R.
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- 2021
25. Navigating the higher education border : routes to belonging for forced migrant students in the UK and Sweden
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Murray, R. E., White, P., and Sporton, D.
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550 - Abstract
This thesis investigates the impact of managed migration policy and practice on forced migrants’ access to, and participation, in higher education. ‘Forced migrant’ is used as a broad non-legal term, which includes individuals with ‘settled’ and ‘unsettled’ claims for asylum. In Western Europe, the perceived influx of forced migrants has reinforced the hostile environment encountered by those whose experiences are characterised by exclusion and limbo. The distinct marginalisation imposed upon forced migrants within civil society is replicated within higher education. Forced migrants with unsettled immigration status are categorised as international students, rendering them ineligible for student funding. Yet, in spite of seemingly insurmountable challenges, it is often central to their aspirations and pursuit to belong in the destination country. This research draws on Foucauldian governmentality, Giddens theory of structuration and Bourdieu’s model of habitus and capital to explore the relationship between forced migration and higher education at different societal scales. This thesis investigates state-led governance, institutional university-level practice and the actions and impact of individuals – agents who work within higher education and forced migrants. A cross-national country comparison between the UK and Sweden, across six university sites, facilitated analysis of locally specific practices and their potential for extrapolation to the European and global level. This thesis responds to a palpable lack of research and data documenting forced migrants’ aspirations and participation in higher education, expanding our knowledge of this area and contributing to empirical and theoretical debates around key themes of displacement, limbo, and belonging. The invisibility of this group and the deficits in forced migrants’ capital contribute to the construction of the ‘higher education border’: wherein state-led managed migration policies of exclusion are enacted, as well as resisted. This thesis interrogates whether British (Article 26 scholarships) and Swedish (intensive language programmes such as Korta Vagen) initiatives targeting forced migrants perpetuate the higher education border and its inherent inequalities or achieve valuable incremental change.
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- 2018
26. Fatigue in psychosis
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Poole-Wright, K., Gaughran, F., Murray, R., and Chalder, T.
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- 2022
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27. A new classification of algebraic identities for linear operators on associative algebras
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Bremner, Murray R. and Elgendy, Hader A.
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- 2022
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28. James Cook University's decentralised medical training model: An important part of the rural workforce pipeline in northern Australia
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Woolley, T, Sen Gupta, T, and Murray, R
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- 2016
29. Erratum to: Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA
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Bousquet, Jean, Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R. E., Somekh, D., Vera-Muñoz, C., Visser, F., Farrell, J., Malva, J., Andersen Ranberg, K., Camuzat, T., Carriazo, A. M., Crooks, G., Gutter, Z., Iaccarino, G., de Keenoy, E. Manuel, Moda, G., Rodriguez-Mañas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M. T., Avolio, F., Bedbrook, A., Białoszewski, A. Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M. F., Catala, A., O’Caoimh, R., Cesari, M., Chavannes, N. H., Correia-Da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W. J., Garcia-Lizana, F., Guérin, O., Hellings, P. W., Haahtela, T., Illario, M., Inzerilli, M. C., Lodrup Carlsen, K. C., Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J. P., Murray, R., Nogues, M., O’Byrne-Maguire, I., Pappa, D., Parent, A. S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A. M., Tsartara, S. I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G. W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I. M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S. H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K. C., Bernard, P. L., Bonini, S., Bousquet, P. J., Branchini, B., Brightling, C. E., Bruguière, V., Bunu, C., Bush, A., Caimmi, D. P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K. H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K. F., D’Angelantonio, M., de Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D. J., Costa, E., Coste, O., Coupet, A. -L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S. E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougère, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioğlu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Héve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S. L., Just, J., Jutel, M., Kaidashev, I. P., Kaitov, M., Kalayci, O., Kalyoncu, A. F., Keijser, W., Kerstjens, H., Knezović, J., Kowalski, M., Koppelman, G. H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Maggio, M., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinarić, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Mösges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N. K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T. A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J. C., Robine, J. M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H. J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Siciliano, P., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Tsartara, S. I., Valero, A. L., Valovirta, E., van Ganse, E., van Hage, M., van den Berge, M., Vandenplas, O., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wickman, M., Wilson, N., Yiallouros, P. K., Žagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., and de Oliveira-Alves, B.
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- 2023
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30. Designing for Learning during Collaborative Projects Online: Tools and Takeaways
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Sankaranarayanan, Sreecharan, Kandimalla, Siddharth Reddy, Cao, Mengxin, Maronna, Ignacio, An, Haokang, Bogart, Chris, Murray, R. Charles, Hilton, Michael, Sakr, Majd, and Penstein Rosé, Carolyn
- Abstract
Purpose: In response to the evolving COVID-19 pandemic, many universities have transitioned to online instruction. With learning promising to be online, at least in part, for the near future, instructors may be thinking of providing online collaborative learning opportunities to their students who are increasingly isolated from their peers because of social distancing guidelines. This paper aims to provide design recommendations for online collaborative project-based learning exercises based on this research in a software engineering course at the university level. Design/methodology/approach: Through joint work between learning scientists, course instructors and software engineering practitioners, instructional design best practices of alignment between the context of the learners, the learning objectives, the task and the assessment are actualized in the design of collaborative programming projects for supporting learning. The design, first segments a short real-time collaborative exercise into tasks, each with a problem-solving phase where students participate in collaborative programming, and a reflection phase for reflecting on what they learned in the task. Within these phases, a role-assignment paradigm scaffolds collaboration by assigning groups of four students to four complementary roles that rotate after each task. Findings: By aligning each task with granular learning objectives, significant pre- to post-test learning from the exercise as well as each task is observed. Originality/value: The roles used in the paradigm discourage divide-and-conquer tendencies often associated with collaborative projects. By requiring students to discuss conflicting ideas to arrive at a consensus implementation, their ideas are made explicit, thus providing opportunities for clarifying misconceptions through discussion and learning from the collaboration.
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- 2020
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31. CONQUEST: A Quality Improvement Program for Defining and Optimizing Standards of Care for Modifiable High-Risk COPD Patients
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Alves L, Pullen R, Hurst JR, Miravitlles M, Carter V, Chen R, Couper A, Dransfield M, Evans A, Hardjojo A, Jones D, Jones R, Kerr M, Kostikas K, Marshall J, Martinez F, Melle MV, Murray R, Muro S, Nordon C, Pollack M, Price C, Sharma A, Singh D, Winders T, and Price DB
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patient-reported outcome ,patient-reported information ,clinical decision support ,primary care ,quality standards ,integrated care ,Medicine (General) ,R5-920 - Abstract
Luis Alves,1 Rachel Pullen,2 John R Hurst,3 Marc Miravitlles,4 Victoria Carter,5 Rongchang Chen,6 Amy Couper,2 Mark Dransfield,7 Alexander Evans,5 Antony Hardjojo,2 David Jones,5 Rupert Jones,8 Margee Kerr,5 Konstantinos Kostikas,9 Jonathan Marshall,10 Fernando Martinez,11 Marije van Melle,5 Ruth Murray,5 Shigeo Muro,12 Clementine Nordon,10 Michael Pollack,13 Chris Price,5 Anita Sharma,14 Dave Singh,15 Tonya Winders,16 David B Price2 1EPIUnit - Epidemiology Research Unit, ITR - Laboratory for Integrative and Translational Research in Population Health, Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal; 2Observational and Pragmatic Research Institute, Singapore, Singapore; 3UCL Respiratory, University College London, London, UK; 4Pneumology Dept, Hospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Barcelona Hospital Campus, CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain; 5Optimum Patient Care, Cambridge, UK; 6Key Laboratory of Respiratory Disease of Shenzhen, Shenzhen Institute of Respiratory Disease, Shenzhen People’s Hospital (Second Affiliated Hospital of Jinan University, First Affiliated Hospital of South University of Science and Technology of China), Shenzhen, Guangdong, People’s Republic of China; 7Division of Pulmonary, Allergy, and Critical Care Medicine, Lung Health Center, University of Alabama at Birmingham, Birmingham, AL, USA; 8Research and Knowledge Exchange, Plymouth Marjon University, Plymouth, UK; 9Respiratory Medicine Department, University of Ioannina School of Medicine, Ioannina, Greece; 10BioPharmaceuticals Medical, AstraZeneca, Cambridge, UK; 11New York-Presbyterian Weill Cornell Medical Center, New York, NY, USA; 12Department of Respiratory Medicine, Nara Medical University, Nara, Japan; 13BioPharmaceuticals Medical, AstraZeneca, Wilmington, DE, USA; 14Platinum Medical Centre, Chermside, QLD, Australia; 15Division of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester, UK; 16USA & Global Allergy & Airways Patient Platform, Vienna, AustriaCorrespondence: David B Price, Observational and Pragmatic Research Institute, 22 Sin Ming Lane, #06-76, Midview City, 573969, Singapore, Tel +65 3105 1489, Email dprice@opri.sgAbstract: The COllaboration on QUality improvement initiative for achieving Excellence in STandards of COPD care (CONQUEST) aims to improve the quality of COPD care in primary care. The CONQUEST target population includes patients diagnosed with COPD, and those undiagnosed but with COPD-like exacerbations, who are at high but modifiable risk of COPD exacerbations, increased morbidity, and mortality. Timely diagnosis and optimized management to reduce these risks is vital. There is a need for a quality improvement program (QIP) that enables long-term improvement of patient clinical outcomes via integration of the program into routine clinical care. Core to the CONQUEST program is the adoption of four specifically designed, globally applicable, and expert-agreed quality standards (QS) for modifiable high-risk COPD patients. Translation of the QS into clinical practice, and implementation of the QIP, is guided by the CONQUEST global operational protocol provided to sites meeting the minimum healthcare system requirements. Initial analyses of current practices are conducted to generate baseline assessments of need within healthcare systems and sites looking to implement the QIP. Implementation is supported by the provision of CONQUEST resources and tools, such as clinical decision support, that promote prompt identification and treatment of patients. Utilization of electronic medical record (EMR) and patient-reported data are integral components of the QIP. Regular, automated collection and analysis of data, combined with a cyclical review of the implementation process, will be conducted for long-term, continuous improvement and health impact evaluation. The CONQUEST QIP will be an important resource in the identification and management of patients with modifiable high-risk COPD. Embedding the CONQUEST QS into routine clinical practice with regular evaluation and feedback will result in long-term quality of care improvement.Keywords: patient-reported outcome, patient-reported information, clinical decision support, primary care, quality standards, integrated care
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- 2022
32. Progress on the Organic and Inorganic Modules of the Spacecraft Water Impurity Monitor, a Next Generation Complete Water Analysis System for Crewed Vehicles
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Stuart J Pensinger, Michael Callahan, Evan L Neidholdt, Aaron C Noell, Nathan J Oborny, Byunghoon Bae, Valeria Lopez, Bruce R Hancock, Marianne P Gonzalez, Margie L Homer, Stojan Madzunkov, Murray R Darrach, and Richard D Kidd
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Inorganic, Organic And Physical Chemistry ,Instrumentation And Photography - Abstract
The Spacecraft Water Impurity Monitor (SWIM) is a joint collaboration to develop an instrument platform that will perform in-flight measurements and deliver a more complete picture of water quality to decision makers. For exploration missions, returned water samples will not be an option, so spacecraft and habitats will need to be equipped with advanced water monitoring capabilities. Eventually, missions to the moon, Mars, and beyond should be equipped with analytical capabilities roughly analogous to those found in terrestrial labs. Based on what we know about current and future spacecraft environments, SWIM will seek to provide enhanced analytical capability that enables NASA to confidently send astronauts on distant missions without the possibility of returned water samples. The SWIM architecture can be broken down in an Organic Water Module (OWM) and an Inorganic Water Module (IWM), independent of each other but can be flown together if desired; an integrated system may share some commonality, e.g., single sample injection, sampling consumables, waste, etc. Each of these main modules can be broken down further into separation (if required) and detection modules. And, each separation module can be paired with one or more detection module depending on mission, spacecraft, customer needs, and size/mass/power constraints. This paper discusses the research and development progress toward the goal of a total water analysis system. For OWM, one of the analysis technologies that the SWIM team have been developing is a liquid-injection gas chromatograph mass spectrometer system; these systems are the workhorses of analytical chemistry laboratories world-wide. For IWM, the team is exploring a number of technologies ranging from traditional liquid chromatography technologies (e.g. ion chromatography, capillary electrophoresis) to flight-heritage technology such as ion-specific electrodes.
- Published
- 2023
33. Cyanobacterial α-carboxysome carbonic anhydrase is allosterically regulated by the Rubisco substrate RuBP
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Pulsford, Sacha B., primary, Outram, Megan A., additional, Förster, Britta, additional, Rhodes, Timothy, additional, Williams, Simon J., additional, Badger, Murray R., additional, Price, G. Dean, additional, Jackson, Colin J., additional, and Long, Benedict M., additional
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- 2024
- Full Text
- View/download PDF
34. The contribution of cannabis use to the increased psychosis risk among minority ethnic groups in Europe
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Selten, J. P., primary, Di Forti, M., additional, Quattrone, D., additional, Jones, P. B., additional, Jongsma, H. E., additional, Gayer-Anderson, C., additional, Szöke, A., additional, Llorca, P. M., additional, Arango, C., additional, Bernardo, M., additional, Sanjuan, J., additional, Santos, J. L., additional, Arrojo, M., additional, Tarricone, I., additional, Berardi, D., additional, Lasalvia, A., additional, Tosato, S., additional, la Cascia, C., additional, Velthorst, E., additional, van der Ven, E. M. A., additional, de Haan, L., additional, Rutten, B. P., additional, van Os, J., additional, Kirkbride, J. B., additional, Morgan, C. M., additional, Murray, R. M., additional, and Termorshuizen, F., additional
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- 2024
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35. Filmmaking with biology undergraduates: combining digital technology with authentic assessment to develop students’ skillset and capabilities for life after graduation
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Wakefield, A., primary, Murray, R. R., additional, and Bell, E., additional
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- 2024
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36. Osteopathic Approach to a Patient with Recurring Low Back Pain following OMT results in Diagnosis of Underlying Gynecological Etiology: A Case Report
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Berkowitz, Murray R., primary
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- 2024
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37. Agent-in-the-Loop: Conversational Agent Support in Service of Reflection for Learning During Collaborative Programming
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Sankaranarayanan, Sreecharan, Kandimalla, Siddharth Reddy, Hasan, Sahil, An, Haokang, Bogart, Christopher, Murray, R. Charles, Hilton, Michael, Sakr, Majd, Rosé, Carolyn, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Bittencourt, Ig Ibert, editor, Cukurova, Mutlu, editor, Muldner, Kasia, editor, Luckin, Rose, editor, and Millán, Eva, editor
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- 2020
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38. A Case of Thrombocytosis Associated with Enoxaparin Therapy in an Adolescent
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Murray R and Tobias JT
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enoxaparin ,thrombocytosis ,platelet count ,heparin ,anticoagulation ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Robert Murray,1 Joseph T Tobias1– 3 1Department of Pediatrics, Division of Pediatric Critical Care Medicine, Nationwide Children’s Hospital, Columbus, OH, USA; 2Department of Anesthesiology & Pain Medicine, Nationwide Children’s Hospital, Columbus, OH, USA; 3Department of Anesthesiology & Pain Medicine, The Ohio State University College of Medicine, Columbus, OH, USACorrespondence: Robert MurrayDepartment of Pediatrics, Division of Pediatric Critical Care Medicine, Nationwide Children’s Hospital, 700 Children’s Drive, Columbus, OH, 43205, USATel +1 614 722-4200Fax +1 614 722-4203Email Robert.Murray@Nationwidechildrens.orgAbstract: Secondary thrombocytosis, often referred to as a reactive thrombocytosis, is more common than primary thrombocytosis and has many potential etiologies including anemia, infection, inflammation, medications, and post-splenectomy. When considering the critically ill patient in the ICU setting potential medication-related etiologies of thrombocytosis should be included in the differential diagnosis. We present a 15-year-old adolescent with a traumatic brain injury who developed thrombocytosis that was temporally related to the administration of enoxaparin. There was a prompt return of the platelet count to normal following the discontinuation of enoxaparin therapy which led to the probable diagnosis of enoxaparin-induced thrombocytosis.Keywords: enoxaparin, thrombocytosis, platelet count, heparin, anticoagulation
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- 2021
39. Multi-decadal planform changes on coral reef islands from atolls and mid-ocean reef platforms of the equatorial Pacific Ocean: Gilbert Islands, Republic of Kiribati
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Sengupta, Meghna, Ford, Murray R., and Kench, Paul S.
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- 2021
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40. The living wage gap—a quantitative measure of poverty in global supply chains
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Hall, Murray R.
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- 2021
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41. Characterization of the second- and third-order nonlinear optical susceptibilities of monolayer MoS$_2$ using multiphoton microscopy
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Woodward, R. I., Murray, R. T., Phelan, C. F., de Oliveira, R. E. P., Runcorn, T. H., Kelleher, E. J. R., Li, S., de Oliveira, E. C., Fechine, G. J. M., Eda, G., and de Matos, C. J. S.
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Condensed Matter - Mesoscale and Nanoscale Physics ,Physics - Optics - Abstract
We report second- and third-harmonic generation in monolayer MoS$_\mathrm{2}$ as a tool for imaging and accurately characterizing the material's nonlinear optical properties under 1560 nm excitation. Using a surface nonlinear optics treatment, we derive expressions relating experimental measurements to second- and third-order nonlinear sheet susceptibility magnitudes, obtaining values of $|\chi_s^{(2)}|=2.0\times10^{-20}$ m$^2$ V$^{-1}$ and for the first time for monolayer MoS$_\mathrm{2}$, $|\chi_s^{(3)}|=1.7\times10^{-28}$ m$^3$ V$^{-2}$. These sheet susceptibilities correspond to effective bulk nonlinear susceptibility values of $|\chi_{b}^{(2)}|=2.9\times10^{-11}$ m V$^{-1}$ and $|\chi_{b}^{(3)}|=2.4\times10^{-19}$ m$^2$ V$^{-2}$, accounting for the sheet thickness. Experimental comparisons between MoS$_\mathrm{2}$ and graphene are also performed, demonstrating $\sim$3.4 times stronger third-order sheet nonlinearity in monolayer MoS$_\mathrm{2}$, highlighting the material's potential for nonlinear photonics in the telecommunications C band., Comment: Accepted by 2D Materials, 28th Oct 2016
- Published
- 2016
42. One-parameter deformations of the diassociative and dendriform operads
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Bremner, Murray R.
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Mathematics - Quantum Algebra ,Mathematics - Rings and Algebras ,17A30 (Primary), 15A21, 15A54, 16S80, 17A50, 17B63, 18D50 (Secondary) - Abstract
Livernet and Loday constructed a polarization of the nonsymmetric associative operad A with one operation into a symmetric operad SA with two operations (the Lie bracket and Jordan product), and defined a one-parameter deformation of SA which includes Poisson algebras. We combine this with the dendriform splitting of an associative operation into the sum of two nonassociative operations, and use Koszul duality for quadratic operads, to construct one-parameter deformations of the nonsymmetric dendriform and diassociative operads into the category of symmetric operads., Comment: 8 pages
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- 2016
43. Inferring the perturbation time from biological time course data
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Yang, Jing, Penfold, Christopher A., Grant, Murray R., and Rattray, Magnus
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Quantitative Biology - Quantitative Methods - Abstract
Time course data are often used to study the changes to a biological process after perturbation. Statistical methods have been developed to determine whether such a perturbation induces changes over time, e.g. comparing a perturbed and unperturbed time course dataset to uncover differences. However, existing methods do not provide a principled statistical approach to identify the specific time when the two time course datasets first begin to diverge after a perturbation; we call this the perturbation time. Estimation of the perturbation time for different variables in a biological process allows us to identify the sequence of events following a perturbation and therefore provides valuable insights into likely causal relationships. In this paper, we propose a Bayesian method to infer the perturbation time given time course data from a wild-type and perturbed system. We use a non-parametric approach based on Gaussian Process regression. We derive a probabilistic model of noise-corrupted and replicated time course data coming from the same profile before the perturbation time and diverging after the perturbation time. The likelihood function can be worked out exactly for this model and the posterior distribution of the perturbation time is obtained by a simple histogram approach, without recourse to complex approximate inference algorithms. We validate the method on simulated data and apply it to study the transcriptional change occurring in Arabidopsis following inoculation with P. syringae pv. tomato DC3000 versus the disarmed strain DC3000hrpA. An R package, DEtime, implementing the method is available at https://github.com/ManchesterBioinference/DEtime along with the data and code required to reproduce all the results., Comment: 63 pages, 20 figures, paper submitted to Bioinformatics
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- 2016
44. Quadratic nonsymmetric quaternary operads
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Bremner, Murray R. and Sánchez-Ortega, Juana
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Mathematics - Rings and Algebras ,Mathematics - Commutative Algebra ,Primary 15A54, Secondary 05C05, 13P10, 13P15, 15A21, 18D50 - Abstract
We use computational linear algebra and commutative algebra to study spaces of relations satisfied by quadrilinear operations. The relations are analogues of associativity in the sense that they are quadratic (every term involves two operations) and nonsymmetric (every term involves the identity permutation of the arguments). We focus on determining those quadratic relations whose cubic consequences have minimal or maximal rank. We approach these problems from the point of view of the theory of algebraic operads., Comment: 25 pages, 15 tables
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- 2015
45. Profiles of cracks formed in tensile Epilayeis of III - V compound seim-conductors
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Murray, R T, primary, Hopkinson, M, additional, and Kiely, C J, additional
- Published
- 2022
- Full Text
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46. CONQUEST Quality Standards: For the Collaboration on Quality Improvement Initiative for Achieving Excellence in Standards of COPD Care
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Pullen R, Miravitlles M, Sharma A, Singh D, Martinez F, Hurst JR, Alves L, Dransfield M, Chen R, Muro S, Winders T, Blango C, Muellerova H, Trudo F, Dorinsky P, Alacqua M, Morris T, Carter V, Couper A, Jones R, Kostikas K, Murray R, and Price DB
- Subjects
identification ,assessment ,intervention ,follow-up ,Diseases of the respiratory system ,RC705-779 - Abstract
Rachel Pullen, 1, 2 Marc Miravitlles, 3 Anita Sharma, 4 Dave Singh, 5 Fernando Martinez, 6 John R Hurst, 7 Luis Alves, 8, 9 Mark Dransfield, 10 Rongchang Chen, 11 Shigeo Muro, 12 Tonya Winders, 13 Christopher Blango, 14 Hana Muellerova, 15 Frank Trudo, 16 Paul Dorinsky, 17 Marianna Alacqua, 15, 18 Tamsin Morris, 19 Victoria Carter, 1, 2 Amy Couper, 1, 2 Rupert Jones, 20 Konstantinos Kostikas, 1, 21 Ruth Murray, 1 David B Price 1, 2, 22 1Observational and Pragmatic Research Institute, Singapore, Singapore; 2Optimum Patient Care, Cambridge, UK; 3Pneumology Dept, Hospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Barcelona Hospital Campus, CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain; 4Platinum Medical Centre, Chermside, QLD, Australia; 5Division of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester University NHS Foundation Trust, Manchester, UK; 6New York-Presbyterian Weill Cornell Medical Center, New York, NY, USA; 7UCL Respiratory, University College London, London, UK; 8EPI Unit, Institute of Public Health, University of Porto, Porto, Portugal; 9Laboratory for Integrative and Translational Research in Population Health (ITR), Porto, Portugal; 10Division of Pulmonary, Allergy, and Critical Care Medicine, Lung Health Center, University of Alabama at Birmingham, Birmingham, AL, USA; 11Key Laboratory of Respiratory Disease of Shenzhen, Shenzhen Institute of Respiratory Disease, Shenzhen People’s Hospital (Second Affiliated Hospital of Jinan University, First Affiliated Hospital of South University of Science and Technology of China), Shenzhen, People’s Republic of China; 12Department of Respiratory Medicine, Nara Medical University, Nara, Japan; 13USA & Global Allergy & Airways Patient Platform, Vienna, Austria; 14Janssen Pharmaceutical Companies of Johnson & Johnson, Philadelphia, PA, USA; 15AstraZeneca, Cambridge, UK; 16AstraZeneca, Wilmington, DE, USA; 17AstraZeneca, Durham, NC, USA; 18CSL Behring SpA, Milan, Italy; 19AstraZeneca, Luton, UK; 20Research and Knowledge Exchange, Plymouth Marjon University, Plymouth, UK; 21Respiratory Medicine Department, University of Ioannina School of Medicine, Ioannina, Greece; 22Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, UKCorrespondence: David B PriceCentre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD, UKTel +65 3105 1489Email dprice@opri.sgBackground: Chronic obstructive pulmonary disease (COPD) are managed predominantly in primary care. However, key opportunities to optimize treatment are often not realized due to unrecognized disease and delayed implementation of appropriate interventions for both diagnosed and undiagnosed individuals. The COllaboratioN on QUality improvement initiative for achieving Excellence in STandards of COPD care (CONQUEST) is the first-of-its-kind, collaborative, interventional COPD registry. It comprises an integrated quality improvement program focusing on patients (diagnosed and undiagnosed) at a modifiable and higher risk of COPD exacerbations. The first step in CONQUEST was the development of quality standards (QS). The QS will be imbedded in routine primary and secondary care, and are designed to drive patient-centered, targeted, risk-based assessment and management optimization. Our aim is to provide an overview of the CONQUEST QS, including how they were developed, as well as the rationale for, and evidence to support, their inclusion in healthcare systems.Methods: The QS were developed (between November 2019 and December 2020) by the CONQUEST Global Steering Committee, including 11 internationally recognized experts with a specialty and research focus in COPD. The process included an extensive literature review, generation of QS draft wording, three iterative rounds of review, and consensus.Results: Four QS were developed: 1) identification of COPD target population, 2) assessment of disease and quantification of future risk, 3) non-pharmacological and pharmacological intervention, and 4) appropriate follow-up. Each QS is followed by a rationale statement and a summary of current guidelines and research evidence relating to the standard and its components.Conclusion: The CONQUEST QS represent an important step in our aim to improve care for patients with COPD in primary and secondary care. They will help to transform the patient journey, by encouraging early intervention to identify, assess, optimally manage and followup COPD patients with modifiable high risk of future exacerbations.Keywords: identification, assessment, intervention, follow-up
- Published
- 2021
47. Effect of Concomitant Benzodiazepine Use on Efficacy and Safety of Esketamine Nasal Spray in Patients with Major Depressive Disorder and Acute Suicidal Ideation or Behavior: Pooled Randomized, Controlled Trials
- Author
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Diekamp B, Borentain S, Fu DJ, Murray R, Heerlein K, Zhang Q, Schüle C, and Mathews M
- Subjects
esketamine ,benzodiazepine ,depression ,suicidal ideation ,rapid-acting ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Bettina Diekamp,1 Stephane Borentain,2 Dong-Jing Fu,3 Robert Murray,4 Kristin Heerlein,1 Qiaoyi Zhang,5 Cornelius Schüle,6 Maju Mathews2 1Department of Medical and Scientific Affairs, Janssen-Cilag GmbH, Neuss, Germany; 2Department of Global Medical Affairs, Janssen Research & Development LLC, Titusville, NJ, USA; 3Department of Neuroscience Clinical Development, Janssen Research & Development LLC, Titusville, NJ, USA; 4Neuroscience Clinical Biostatistics, Janssen Research & Development LLC, Titusville, NJ, USA; 5Global Market Access, Neuroscience, Janssen Global Services, LLC, Titusville, NJ, USA; 6Ludwig-Maximilians-University Munich, Clinic for Psychiatry and Psychotherapy, Munich, GermanyCorrespondence: Bettina DiekampDepartment of Medical and Scientific Affairs, Janssen-Cilag GmbH, Johnson & Johnson Platz 1, Neuss, 41470, GermanyTel +49-21379556179Email bdiekamp@its.jnj.comPurpose: The impact of benzodiazepines on the efficacy and safety of esketamine as a rapid-acting antidepressant remains unclear.Materials and Methods: Data from two identically designed, randomized double-blind studies were pooled and analyzed on a post-hoc basis. In both studies, adults with major depressive disorder with acute suicidal ideation or behavior were randomized to placebo or esketamine 84 mg nasal spray twice-weekly for 4 weeks, each with comprehensive standard-of-care (initial hospitalization and newly initiated or optimized oral antidepressant[s]). Efficacy and safety were analyzed in two groups based on whether patients used concomitant benzodiazepines, which were prohibited within 8 hours before and 4 hours after the first dose of esketamine and within 8 hours of the primary efficacy assessment at 24 hours. The primary efficacy endpoint – change from baseline to 24 hours post-first dose in Montgomery-Asberg Depression Rating Scale (MADRS) total score – was analyzed using ANCOVA.Results: Most patients (309/451, 68.5%) used concomitant benzodiazepines. Greater decrease in MADRS total score was observed with esketamine (mean [SD]: − 16.1 [11.73]) versus placebo (− 12.6 [10.56]) at 24 hours (least-squares mean difference: − 3.7, 95% CI: − 5.76, − 1.59). The differences between the esketamine and placebo groups were clinically meaningful, irrespective of benzodiazepine use (benzodiazepine: − 4.3 [− 6.63, − 1.89]; no benzodiazepine: − 3.1 [− 6.62, 0.45]). Among patients taking esketamine, change in MADRS total score was not significantly different between patients taking benzodiazepines (− 15.8 [11.27]) versus those not taking benzodiazepines (− 16.8 [12.82]) (least-squares mean difference: 1.1, [− 2.24, 4.45]). Among esketamine-treated patients, the incidence of sedation was higher with benzodiazepine use, whereas dissociation was similar.Conclusion: Benzodiazepines do not meaningfully affect the rapid-acting antidepressant effect of esketamine at 24 hours post-first dose among patients with MDD and acute suicidal ideation or behavior.Keywords: esketamine, benzodiazepine, depression, suicidal ideation, rapid-acting
- Published
- 2021
48. Shoreline changes in coral reef islands of the Federated States of Micronesia since the mid-20th century
- Author
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Sengupta, Meghna, Ford, Murray R., and Kench, Paul S.
- Published
- 2021
- Full Text
- View/download PDF
49. Mehler reaction plays a role in C3 and C4 photosynthesis under shade and low CO2
- Author
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Sagun, Julius Ver, Badger, Murray R., Chow, Wah Soon, and Ghannoum, Oula
- Published
- 2021
- Full Text
- View/download PDF
50. Self-reported suicidal ideation among individuals with first episode psychosis and healthy controls:Findings from the international multicentre EU-GEI study
- Author
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Heuschen, C. B.B.C.M., Bolhuis, K., Zantvoord, J. B., Bockting, C. L., Denys, D. A.J.P., Lok, A., Arango, C., Arrojo, M., Bernardo, M., Bobes, J., Del-Ben, C. M., Di Forti, M., Gayer-Anderson, C., Jones, P. B., Jongsma, H. E., Kirkbride, J. B., La Cascia, C., Lasalvia, A., Tosato, S., Llorca, P. M., Menezes, P. R., Murray, R. M., Quattrone, D., Rutten, B. P., Sanjuán, J., Selten, J. P., Szöke, A., Tarricone, I., Tortelli, A., Velthorst, E., de Haan, L., Schirmbeck, F., Heuschen, C. B.B.C.M., Bolhuis, K., Zantvoord, J. B., Bockting, C. L., Denys, D. A.J.P., Lok, A., Arango, C., Arrojo, M., Bernardo, M., Bobes, J., Del-Ben, C. M., Di Forti, M., Gayer-Anderson, C., Jones, P. B., Jongsma, H. E., Kirkbride, J. B., La Cascia, C., Lasalvia, A., Tosato, S., Llorca, P. M., Menezes, P. R., Murray, R. M., Quattrone, D., Rutten, B. P., Sanjuán, J., Selten, J. P., Szöke, A., Tarricone, I., Tortelli, A., Velthorst, E., de Haan, L., and Schirmbeck, F.
- Abstract
Introduction: Suicidal ideation is common among individuals with first episode psychosis (FEP), with prevalence estimates up to 56.5 %. Despite its high prevalence, relatively little is known about how sociodemographic, clinical and/or developmental characteristics contribute to the experience of suicidal ideation in individuals with FEP. Methods: In this cross-sectional study (FEP n = 551 and controls n = 857), univariate logistic regression analyses were performed to study the associations of sociodemographic, clinical, and developmental factors with suicidal ideation in individuals with FEP as well as controls. Suicidal ideation was assessed using the Community Assessment of Psychic Experiences (CAPE). In addition, multivariate logistic regression analyses were conducted based on a stepwise approach. Results: In FEP, only depressive symptoms remained significantly associated with suicidal ideation when all correlates were integrated into one model. In the multivariate model in controls, depressive symptoms, positive symptoms, and traumatic childhood experiences were significantly associated with suicidal ideation. Conclusions: This study showed that depressive symptoms are an important factor relating to suicidal ideation in individuals with FEP, over and above other clinical, sociodemographic, and developmental factors. This underscores the relevance of screening for suicidal ideation in individuals with FEP, and highlights the need for a better understanding of the diagnostic uncertainty and course of mood symptoms in early psychosis. Limitations: Cross-sectional study design, self-reported questionnaires.
- Published
- 2024
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