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31 results on '"Murray, Kim M."'

1. Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis

Author

Chour, William, Choi, Jongchan, Xie, Jingyi, Chaffee, Mary E., Schmitt, Thomas M., Finton, Kathryn, DeLucia, Diana C., Xu, Alexander M., Su, Yapeng, Chen, Daniel G., Zhang, Rongyu, Yuan, Dan, Hong, Sunga, Ng, Alphonsus H. C., Butler, Jonah Z., Edmark, Rick A., Jones, Lesley C., Murray, Kim M., Peng, Songming, Li, Guideng, Strong, Roland K., Lee, John K., Goldman, Jason D., Greenberg, Philip D., and Heath, James R.

Published
2023
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2. Reinfection with SARS-CoV-2 and Waning Humoral Immunity: A Case Report

Author

Goldman, Jason D., primary, Wang, Kai, additional, Röltgen, Katharina, additional, Nielsen, Sandra C. A., additional, Roach, Jared C., additional, Naccache, Samia N., additional, Yang, Fan, additional, Wirz, Oliver F., additional, Yost, Kathryn E., additional, Lee, Ji-Yeun, additional, Chun, Kelly, additional, Wrin, Terri, additional, Petropoulos, Christos J., additional, Lee, Inyoul, additional, Fallen, Shannon, additional, Manner, Paula M., additional, Wallick, Julie A., additional, Algren, Heather A., additional, Murray, Kim M., additional, Hadlock, Jennifer, additional, Chen, Daniel, additional, Dai, Chengzhen L., additional, Yuan, Dan, additional, Su, Yapeng, additional, Jeharajah, Joshua, additional, Berrington, William R., additional, Pappas, George P., additional, Nyatsatsang, Sonam T., additional, Greninger, Alexander L., additional, Satpathy, Ansuman T., additional, Pauk, John S., additional, Boyd, Scott D., additional, and Heath, James R., additional

Published
2022
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3. Reinfection with SARS-CoV-2 and Waning Humoral Immunity: A Case Report.

Author

Goldman, Jason D., Wang, Kai, Röltgen, Katharina, Nielsen, Sandra C. A., Roach, Jared C., Naccache, Samia N., Yang, Fan, Wirz, Oliver F., Yost, Kathryn E., Lee, Ji-Yeun, Chun, Kelly, Wrin, Terri, Petropoulos, Christos J., Lee, Inyoul, Fallen, Shannon, Manner, Paula M., Wallick, Julie A., Algren, Heather A., Murray, Kim M., and Hadlock, Jennifer

Subjects
HUMORAL immunity, REINFECTION, SARS-CoV-2, B cells, VIRAL shedding
Abstract

Recovery from COVID-19 is associated with production of anti-SARS-CoV-2 antibodies, but it is uncertain whether these confer immunity. We describe viral RNA shedding duration in hospitalized patients and identify patients with recurrent shedding. We sequenced viruses from two distinct episodes of symptomatic COVID-19 separated by 144 days in a single patient, to conclusively describe reinfection with a different strain harboring the spike variant D614G. This case of reinfection was one of the first cases of reinfection reported in 2020. With antibody, B cell and T cell analytics, we show correlates of adaptive immunity at reinfection, including a differential response in neutralizing antibodies to a D614G pseudovirus. Finally, we discuss implications for vaccine programs and begin to define benchmarks for protection against reinfection from SARS-CoV-2. [ABSTRACT FROM AUTHOR]

Published
2023
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4. Angiotensin II receptor I auto-antibodies following SARS-CoV-2 infection

Author

Jiang, Yonghou, primary, Duffy, Fergal, additional, Hadlock, Jennifer, additional, Raappana, Andrew, additional, Styrchak, Sheila, additional, Beck, Ingrid, additional, Mast, Fred D., additional, Miller, Leslie R., additional, Chour, William, additional, Houck, John, additional, Armistead, Blair, additional, Duvvuri, Venkata R., additional, Yeung, Winnie, additional, Haglund, Micaela, additional, Wallner, Jackson, additional, Wallick, Julie A., additional, Hardy, Samantha, additional, Oldroyd, Alyssa, additional, Ko, Daisy, additional, Gervassi, Ana, additional, Murray, Kim M., additional, Kaplan, Henry, additional, Aitchison, John D., additional, Heath, James R., additional, Sather, D. Noah, additional, Goldman, Jason D., additional, Frenkel, Lisa, additional, and Harrington, Whitney E., additional

Published
2021
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5. Angiotensin II receptor I auto-antibodies following SARS-CoV-2 infection

Author

Harrington, Whitney E., primary, Jiang, Yonghou, additional, Duffy, Fergal, additional, Hadlock, Jennifer, additional, Raappana, Andrew, additional, Styrchak, Sheila, additional, Beck, Ingrid, additional, Chour, William, additional, Houck, John, additional, Duvvuri, Venkata, additional, Yeung, Winnie, additional, Haglund, Micaela, additional, Wallner, Jackson, additional, Wallick, Julie A., additional, Hardy, Samantha, additional, Oldroyd, Alyssa, additional, Ko, Daisy, additional, Gervassi, Ana, additional, Murray, Kim M., additional, Kaplan, Henry, additional, Aitchison, John D., additional, Heath, James R., additional, Sather, D. Noah, additional, Goldman, Jason D., additional, and Frenkel, Lisa, additional

Published
2021
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6. Angiotensin II receptor I auto-antibodies following SARS-CoV-2 infection

Author

Harrington, Whitney E., Jiang, Yonghou, Duffy, Fergal, Hadlock, Jennifer, Raappana, Andrew, Styrchak, Sheila, Beck, Ingrid, Chour, William, Houck, John, Duvvuri, Venkata, Yeung, Winnie, Haglund, Micaela, Wallner, Jackson, Wallick, Julie A., Hardy, Samantha, Oldroyd, Alyssa, Ko, Daisy, Gervassi, Ana, Murray, Kim M., Kaplan, Henry, Aitchison, John D., Heath, James R., Sather, D. Noah, Goldman, Jason D., Frenkel, Lisa, Harrington, Whitney E., Jiang, Yonghou, Duffy, Fergal, Hadlock, Jennifer, Raappana, Andrew, Styrchak, Sheila, Beck, Ingrid, Chour, William, Houck, John, Duvvuri, Venkata, Yeung, Winnie, Haglund, Micaela, Wallner, Jackson, Wallick, Julie A., Hardy, Samantha, Oldroyd, Alyssa, Ko, Daisy, Gervassi, Ana, Murray, Kim M., Kaplan, Henry, Aitchison, John D., Heath, James R., Sather, D. Noah, Goldman, Jason D., and Frenkel, Lisa

Abstract

Background: Coronavirus disease 2019 (COVID-19) is associated with endothelial activation and coagulopathy, which may be related to pre-existing or infection-induced pro-thrombotic autoantibodies such as those targeting angiotensin II type I receptor (AT1R-Ab). Methods: We compared prevalence and levels of AT1R-Ab in COVID-19 cases with mild or severe disease to age and sex matched negative controls. Results: There were no significant differences between cases and controls. However, there were trends toward a higher proportion with AT1R-Ab positivity among severe cases versus controls (32% vs. 11%, p=0.1) and higher levels in those with mild COVID-19 compared to controls (median 9.5U/mL vs. 5.9U/mL, p=0.06). Conclusions: These findings suggest that AT1R-Ab are not consistently associated with COVID-19 but do not exclude a contribution to endothelial pathology in a subset of people.

Published
2021

7. Shared Antigen-specific CD8⁺ T cell Responses Against the SARS-COV-2 Spike Protein in HLA A*02:01 COVID-19 Participants

Author

Chour, William, Xu, Alexander M., Ng, Alphonsus H. C., Choi, Jongchan, Xie, Jingyi, Yuan, Dan, Delucia, Diane C., Edmark, Rick A., Jones, Lesley C., Schmitt, Thomas M., Chaffee, Mary E., Duvvuri, Venkata R., Murray, Kim M., Peng, Songming, Wallick, Julie, Algren, Heather A., Berrington, William R., O'Mahoney, D. Shane, Lee, John K., Greenberg, Philip D., Goldman, Jason D., Heath, James R., Chour, William, Xu, Alexander M., Ng, Alphonsus H. C., Choi, Jongchan, Xie, Jingyi, Yuan, Dan, Delucia, Diane C., Edmark, Rick A., Jones, Lesley C., Schmitt, Thomas M., Chaffee, Mary E., Duvvuri, Venkata R., Murray, Kim M., Peng, Songming, Wallick, Julie, Algren, Heather A., Berrington, William R., O'Mahoney, D. Shane, Lee, John K., Greenberg, Philip D., Goldman, Jason D., and Heath, James R.

Abstract

We report here on antigens from the SARS-CoV-2 virus spike protein, that when presented by Class I MHC, can lead to cytotoxic CD8⁺ T cell anti-viral responses in COVID-19 patients. We present a method in which the SARS-CoV-2 spike protein is converted into a library of peptide antigen-Major Histocompatibility Complexes (pMHCs) as single chain trimers that contain the peptide antigen, the MHC HLA allele, and the β-2 microglobulin sub-unit. That library is used to detect the evolution of virus-specific T cell populations from two COVID-19 patients, at two time points over the course of infection. Both patients exhibit similar virus-specific T cell populations, but very different time-trajectories of those populations. These results can be used to track those virus-specific T cell populations over the course of an infection, thus providing deep insight into the variations in immune system trajectories observed in different COVID-19 patients.

Published
2020

10. Reinfection with SARS-CoV-2 and Failure of Humoral Immunity: a case report

Author

Goldman, Jason D., primary, Wang, Kai, additional, Röltgen, Katharina, additional, Nielsen, Sandra C. A., additional, Roach, Jared C., additional, Naccache, Samia N., additional, Yang, Fan, additional, Wirz, Oliver F., additional, Yost, Kathryn E., additional, Lee, Ji-Yeun, additional, Chun, Kelly, additional, Wrin, Terri, additional, Petropoulos, Christos J., additional, Lee, Inyoul, additional, Fallen, Shannon, additional, Manner, Paula M., additional, Wallick, Julie A., additional, Algren, Heather A., additional, Murray, Kim M., additional, Su, Yapeng, additional, Hadlock, Jennifer, additional, Jeharajah, Joshua, additional, Berrington, William R., additional, Pappas, George P., additional, Nyatsatsang, Sonam T., additional, Greninger, Alexander L., additional, Satpathy, Ansuman T., additional, Pauk, John S., additional, Boyd, Scott D., additional, and Heath, James R., additional

Published
2020
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24. Review of Drug-Induced Acute Interstitial Nephritis.

Author

Murray, Kim M. and Keane, William R.

Abstract

Drug-induced acute interstitial nephritis (AIN) is a rare, potentially correctable cause of acute renal failure. Early recognition and appropriate therapy are essential to its management. Several drugs have been associated with the development of AIN, including antibiotics and nonsteroidal antiinflammatory agents, all with characteristic mechanisms of toxicity. [ABSTRACT FROM AUTHOR]

Published
1992
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25. Intravenous Self-Administration of Elemental Mercury: Efficacy of Dimercaprol Therapy

Author

Murray, Kim M. and Hedgepeth, Jennifer C.

Abstract

Deliberate parenteral self-injection of mercury is extremely rare, and is associated with a high degree of mortality and morbidity. Because mercury depresses cellular enzymatic mechanisms by combining with sulfhydryl groups, soluble mercuric salts are toxic to all cells. Embolization of mercury in the lungs has been reported with varying degrees of changes in pulmonary function. Mercury causes urticaria progressing to weeping dermatitis, leukopenia, anemia, diarrhea, salivation, liver damage, and renal damage progressing to acute renal failure with anuria. Dimercaprol is an effective antidote in acute heavy metal intoxication because its two sulfhydryl groups successfully compete with tissue enzyme sulfhydryl groups for the offending metal. Experience with dimercaprol therapy months after the original exposure to mercury is not available. We describe the hospital course of a patient after intravenous elemental injection and the results of dimercaprol therapy months after the original exposure.

Published
1988
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29. Suspected Ciprofloxacin-Induced Interstitial Nephritis

Author

Murray, Kim M. and Wilson, Malissa G.

Abstract

Interstitial nephritis is a rare but serious adverse effect of many drugs and usually is diagnosed by clinical signs and symptoms of hematuria, proteinuria, eosinophilia, fever, azotemia, and rash. Ciprofloxacin is one drug that has been reported to cause interstitial nephritis. Renal toxicities have been reported in less than one percent of the patients receiving ciprofloxacin therapy. Limited documentation of this adverse effect exists in the literature. This article describes a patient with suspected ciprofloxacin-induced interstitial nephritis.

Published
1990
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31. Reinfection with SARS-CoV-2 and Failure of Humoral Immunity: a case report.

Author

Goldman JD, Wang K, Röltgen K, Nielsen SCA, Roach JC, Naccache SN, Yang F, Wirz OF, Yost KE, Lee JY, Chun K, Wrin T, Petropoulos CJ, Lee I, Fallen S, Manner PM, Wallick JA, Algren HA, Murray KM, Su Y, Hadlock J, Jeharajah J, Berrington WR, Pappas GP, Nyatsatsang ST, Greninger AL, Satpathy AT, Pauk JS, Boyd SD, and Heath JR

Abstract

Recovery from COVID-19 is associated with production of anti-SARS-CoV-2 antibodies, but it is uncertain whether these confer immunity. We describe viral RNA shedding duration in hospitalized patients and identify patients with recurrent shedding. We sequenced viruses from two distinct episodes of symptomatic COVID-19 separated by 144 days in a single patient, to conclusively describe reinfection with a new strain harboring the spike variant D614G. With antibody and B cell analytics, we show correlates of adaptive immunity, including a differential response to D614G. Finally, we discuss implications for vaccine programs and begin to define benchmarks for protection against reinfection from SARS-CoV-2.

Published
2020
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