176 results on '"Murray, James B."'
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2. Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures
3. A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase.
4. Roles of Nrf2 in drug and chemical toxicity
5. A Helical Twist-induced Conformational Switch Activates Cleavage in the Hammerhead Ribozyme
6. A pH-dependent conformational change, rather than the chemical step, appears to be rate-limiting in the hammerhead ribozyme cleavage reaction11Edited by J. Doudna
7. Capturing the Structure of a Catalytic RNA Intermediate: The Hammerhead Ribozyme
8. Capture and Visualization of a Catalytic RNA Enzyme-Product Complex Using Crystal Lattice Trapping and X-Ray Holographic Reconstruction
9. Does a single metal ion bridge the A-9 and scissile phosphate groups in the catalytically active hammerhead ribozyme structure?11Edited by J. Karn
10. The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations alone
11. The cost of diagnostic uncertainty: a prospective economic analysis of febrile children attending an NHS emergency department
12. Paleoecological Insights on Fixed Tree Island Development in the Florida Everglades: I. Environmental Controls
13. PAC-FragmentDEL – photoactivated covalent capture of DNA-encoded fragments for hit discovery
14. The Effect of Core Replacement on S64315, a Selective MCL-1 Inhibitor, and Its Analogues
15. Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B
16. A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells
17. A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinaseElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3md00439b
18. Experiences in Fragment-Based Lead Discovery
19. Physical property data from the ICDP-USGS Eyreville cores A and B, Chesapeake Bay impact structure, Virginia, USA, acquired using a multisensor core logger
20. The structural basis of hammerhead ribozyme self-cleavage
21. Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding
22. [13] Conventional and time-resolved ribozyme X-ray crystallography
23. Crystal structure of an RNA bacteriophage coat protein-operator complex
24. Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1
25. PAC-FragmentDEL – photoactivated covalent capture of DNA-encoded fragments for hit discoveryElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2md00197g
26. THE EFFECTS OF CITIZENS' SUITS UPON LOCAL ENFORCEMENT
27. Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1)
28. Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase
29. The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography
30. Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1)
31. A pH-dependent conformational change, rather than the chemical step, appears to be rate-limiting in the hammerhead ribozyme cleavage reaction.
32. Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution
33. Structure-guided design of α-amino acid-derived Pin1 inhibitors
34. Off-Rate Screening (ORS) By Surface Plasmon Resonance. An Efficient Method to Kinetically Sample Hit to Lead Chemical Space from Unpurified Reaction Products
35. Shielded Hydrogen Bonds as Structural Determinants of Binding Kinetics: Application in Drug Design
36. Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity
37. Corrigendum to “Structure-guided design of α-amino acid-derived Pin1 inhibitors” [Bioorg. Med. Chem. Lett. 20 (2010) 586]
38. Abstract 4432: Discovery of novel Pin1 inhibitors by structure-guided fragment evolution that downregulate cyclin D1 expression in PC-3 prostate cancer cells
39. A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells
40. Abstract A212: A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor‐induced apoptosis in HCT116 colon carcinoma cells
41. Novel Adenosine-Derived Inhibitors of 70 kDa Heat Shock Protein, Discovered Through Structure-Based Design
42. Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping
43. Letters.
44. Red-Rimmed Melania (Melanoides tuberculatus) - A snail in Biscayne National Park, Florida - Harmful invader or just a nuisance?
45. Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: Protein structure-guided design and SAR
46. Interactions of Designer Antibiotics and the Bacterial Ribosomal Aminoacyl-tRNA Site
47. Descriptions and Preliminary Report on Sediment Cores from the Southwest Coastal Area, Part II: Collected July 2005, Everglades National Park, Florida
48. Salinity and Temperature Tolerance Experiments on Selected Florida Bay Mollusks
49. Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2
50. RNA Bacteriophage Capsid-Mediated Drug Delivery and Epitope Presentation
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