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4. Landscape fire smoke airway exposure impairs respiratory and cardiac function and worsens experimental asthma

Author

Gomez, Henry M., Haw, Tatt J., Ilic, Dusan, Robinson, Peter, Donovan, Chantal, Croft, Amanda J., Vanka, Kanth S., Small, Ellen, Carroll, Olivia R., Kim, Richard Y., Mayall, Jemma R., Beyene, Tesfalidet, Palanisami, Thava, Ngo, Doan T.M., Zosky, Graeme R., Holliday, Elizabeth G., Jensen, Megan E., McDonald, Vanessa M., Murphy, Vanessa E., Gibson, Peter G., and Horvat, Jay C.

Published
2024
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9. Impact of Landscape Fire Smoke Exposure on Patients With Asthma With or Without Laryngeal Hypersensitivity

Author

Vertigan, Anne E., Harvey, Erin S., Beyene, Tesfalidet, Van Buskirk, Joseph, Holliday, Elizabeth G., Bone, Sarah L., McDonald, Vanessa M., Horvat, Jay C., Murphy, Vanessa E., Jensen, Megan E., Morgan, Geoffrey G., Zosky, Graeme R., Peters, Matthew, Farah, Claude S., Jenkins, Christine R., Katelaris, Constance H., Harrington, John, Langton, David, Bardin, Philip, Katsoulotos, Gregory P., Upham, John W., Chien, Jimmy, Bowden, Jeffrey J., Rimmer, Janet, Bell, Rose, and Gibson, Peter G.

Published
2023
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19. Longitudinal Analysis of Lung Function in Pregnant Women with and without Asthma

Author

Gibson, Peter G., Clifton, Vicki, Giles, Warwick, Murphy, Vanessa E., Woods, Andrew, McCaffery, Kirsten, Mattes, Joerg, Peek, Michael, Bisits, Andrew, Callaway, Leonie, Barrett, Helen, Attia, John, Doran, Christopher, Seeho, Sean K.M., Colditz, Paul, Jensen, Megan, Searles, Andrew, Abbott, Alistair, Jensen, Megan E., Robijn, Annelies L., and Oldmeadow, Christopher

Published
2021
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21. Asthma in Pregnancy

Author

Murphy, Vanessa E., primary, Bokern, Marleen, additional, McLaughlin, Karen, additional, and Gibson, Peter G., additional

Published
2022
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22. Cord blood granulocyte levels are associated with severe bronchiolitis in the first year of life.

Author

Martins Costa Gomes, Gabriela, Da Silva Sena, Carla Rebeca, Murphy, Vanessa E, Hansbro, Philip M, Starkey, Malcolm R, Gibson, Peter G, Mattes, Joerg, and Collison, Adam M

Subjects
CORD blood, RECEIVER operating characteristic curves, CESAREAN section, BRONCHIOLITIS, CD45 antigen
Abstract

Objectives: Bronchiolitis is a leading cause of infant hospitalisation in the first year of life, and it preferentially affects infants born to mothers with asthma. Here, we evaluate cord blood granulocytes in infants born to mothers with asthma participating in the Breathing for Life Trial (BLT), to investigate early life determinants of bronchiolitis hospitalisation within the first year of life. Methods: Cord blood from 89 participants was collected into EDTA tubes and processed within 6 h of birth. Cells were stained in whole cord blood for eosinophils (CD45+, CD193+, CD16−), and neutrophils (CD45+, CD193−, CD16+). Medical records were reviewed for bronchiolitis hospitalisation in the first 12 months of life. Statistical analyses were conducted using Stata IC16.1. Results: Logistic regression adjusted for caesarean section, gestational age, maternal smoking during pregnancy, foetal heart deceleration during labour, and season of birth revealed an association between cord blood eosinophil levels and bronchiolitis hospitalisation in the first 12 months of life with an Area Under the Curve (AUC) of the Receiver Operating Characteristic (ROC) curve of 0.943 (aOR = 1.35, P = 0.011). Neutrophils were associated with the risk of bronchiolitis hospitalisation in a univariable logistic regression (OR = 0.93, P = 0.029); however, there was no statistical significance in the adjusted model. Conclusions: Higher eosinophil numbers in cord blood were associated with bronchiolitis hospitalisation in the first 12 months in a cohort of infants born to asthmatic mothers. This suggests that susceptibility to bronchiolitis in later life is influenced by the immune cell profile prior to viral infection. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Effect of fractional exhaled nitric oxide (FENO)-based asthma management during pregnancy versus usual care on infant development, temperament, sensory function and autism signs.

Author

Whalen, Olivia M., Campbell, Linda E., Lane, Alison E., Karayanidis, Frini, Mallise, Carly A., Woolard, Alix J., Holliday, Elizabeth G., Mattes, Joerg, Collison, Adam, Gibson, Peter G., and Murphy, Vanessa E.

Subjects
INFANT development, INFANT care, ASTHMA, NITRIC oxide, AUTISM, INFANT health, CRYING, PRECONCEPTION care
Abstract

Asthma during pregnancy is associated with a range of adverse perinatal outcomes. It is also linked to increased rates of neurodevelopmental conditions in the offspring. We aimed to assess whether fractional exhaled nitric oxide (FENO)-based asthma management during pregnancy improves child developmental and behavioural outcomes compared to usual care. The Breathing for Life Trial was a randomised controlled trial that compared FENO-based asthma management during pregnancy to usual care. Participants were invited to the developmental follow-up, the Breathing for Life Trial – Infant Development study, which followed up infants at 6 weeks, 6 months and 12 months. The primary outcomes were measured in infants at 12 months using the Bayley-III: Cognitive, Language and Motor composite scores. Secondary outcomes included Bayley-III social-emotional and adaptive behaviour scores, autism likelihood and sensory and temperament outcomes. The exposure of interest was the randomised intervention group. Two hundred and twenty-two infants and their 217 participating mothers were recruited to the follow-up; 107 mothers were in the intervention group and 113 were in the control group. There was no evidence of an intervention effect for the primary outcomes: Bayley-III cognitive (mean = 108.9 control, 108.5 intervention, p = 0.93), language (mean = 95.9 control, 95.6 intervention, p = 0.87) and motor composite scores (mean = 97.2 control, 97.9 intervention, p = 0.25). Mean scores for secondary outcomes were also similar among infants born to control and FENO group mothers, with few results reaching p < 0.05. Conclusion: In this sample, FENO-guided asthma treatment during pregnancy did not improve infant developmental outcomes in the first year of life. Trial registration: ClinicalTrials.gov Identifier: ACTRN12613000202763. What is Known: • Maternal asthma during pregnancy has been associated with increased rates of neurodevelopmental conditions in offspring, including intellectual disability and autism. What is New: • This is the first study to examine how managing asthma during pregnancy via a FENO-guided algorithm or usual care affects infant developmental and behavioural outcomes. While the results of the study showed no impact of the intervention, and therefore do not support the integration of FENO-based management of asthma in antenatal settings for optimal infant development, they do send a positive message about the implications of active asthma management during pregnancy on infant developmental outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Bronchiolitis hospital admission in infancy is associated with later preschool ventilation inhomogeneity

Author

Sena, Carla Rebeca Da Silva, primary, Morten, Matthew, additional, Collison, Adam M., additional, Shaar, Aida, additional, Andrade, Ediane de Queiroz, additional, Meredith, Joseph, additional, Kepreotes, Elizabeth, additional, Murphy, Vanessa E., additional, Sly, Peter D., additional, Whitehead, Bruce, additional, Karmaus, Wilfried, additional, Gibson, Peter G., additional, Robinson, Paul D., additional, and Mattes, Joerg, additional

Published
2023
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46. Additional file 1 of The impact of prolonged landscape fire smoke exposure on women with asthma in Australia

Author

Beyene, Tesfalidet, Murphy, Vanessa E., Gibson, Peter G., McDonald, Vanessa M., Van Buskirk, Joe, Holliday, Elizabeth G., Vertigan, Anne E., Horvat, Jay C., Zosky, Graeme R., Morgan, Geoffrey G., Jegasothy, Edward, Hanigan, Ivan, Mattes, Joerg, Collison, Adam M., and Jensen, Megan E.

Abstract

Additional file 1: Fig. S1. Landscape fire smoke exposure during the 2019/2020 Australian Black Summer fire period. Exposure was assessed using PM2.5 measures from fixed monitoring stations for Sydney Greater Metropolitan Region (New South Wales) (Panel A) and Melbourne (Panel B) regions. Validation of landscape fire activity was obtained from images as seen by the Moderate Resolution Imaging Spectroradiometer (MODIS) Terra Satellite. (A) Population-weighted mean daily PM2.5 concentration in the Sydney Greater Metropolitan Region (New South Wales) during the 2019/2020 fire period. (B) Population-weighted mean daily PM2.5 concentrations in the Melbourne Region (Victoria) during the 2019/2020 fire period. (C) Landscape fire days identified in the Sydney Greater Metropolitan Region (New South Wales) during the 2019/2020 fire period. (D) Landscape fire days identified in the Melbourne region during the 2019/2020 fire period. (E) Fire hot spots and smoke plumes in the Sydney region as seen by the MODIS Terra satellite on 4 December 2019. (F) Fire hot spots and smoke plumes in the Melbourne region as seen by the MODIS Terra satellite on 14 January 2020. The orange dot indicates fires. Fig. S2. Symptoms reported by women with asthma, including pregnant and breastfeeding women, during and following the 2019/20 Australian Black Summer landscape fire period. *indicates statistically significant difference in symptom during versus following the fire period. ** p < 0.001, * p < 0.05. Table S1. Self-reported asthma symptoms during the fire period experienced by women with asthma, including pregnant and breastfeeding women, during and following the 2019/2020 Australian Black Summer landscape fire period. Table S2. Source of information/advice on symptoms, asthma management and minimising exposure to landscape fire smoke reported by women with asthma, including pregnant and breastfeeding women during the 2019/20 Australian landscape fires. Fig. S3. Actions taken by women with asthma, including pregnant and breastfeeding women to minimise exposure to landscape fire smoke during the 2019/20 Australian landscape fires. Fig. S4. Impact of prolonged smoke exposure from the 2019/20 Australian landscape fires on quality of life in women with asthma, including pregnant and breastfeeding women. Fig. S5. Mean anxiety score amongst women with asthma, including pregnant and breastfeeding women, during, and after, the 2019/20 Australian landscape fires. The horizontal dashed line indicates a cut-off point for clinically significant symptoms of anxiety using the STAI-20. Error bars indicate the standard deviation. *indicates statistically significant difference in anxiety during versus following the fire period [p < 0.001].

Published
2023
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