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14. mHealth_Supplement – Supplemental material for Efficacy of Smartphone-Based Secondary Preventive Strategies in Coronary Artery Disease

Author

Murphy, Alexandra C, Meehan, Georgina, Anoop N Koshy, Phelia Kunniardy, Farouque, Omar, and Yudi, Matias B

Subjects
Cardiology
Abstract

Supplemental material, mHealth_Supplement for Efficacy of Smartphone-Based Secondary Preventive Strategies in Coronary Artery Disease by Alexandra C Murphy, Georgina Meehan, Anoop N Koshy, Phelia Kunniardy, Omar Farouque and Matias B Yudi in Clinical Medicine Insights: Cardiology

Published
2020
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23. Prognostic significance of suboptimal secondary prevention pharmacotherapy after acute coronary syndromes.

Author

Yudi, Matias B., Farouque, Omar, Andrianopoulos, Nick, Ajani, Andrew E., Brennan, Angela, Murphy, Alexandra C., Lefkovits, Jeffrey, Reid, Christopher M., Oqueli, Ernesto, Sebastian, Martin, Duffy, Stephen J., and Clark, David J.

Subjects
PERCUTANEOUS coronary intervention, CONFIDENCE intervals, MORTALITY, ACUTE coronary syndrome, DRUGS, SURVIVAL analysis (Biometry), DESCRIPTIVE statistics, PATIENT compliance, ODDS ratio, PROPORTIONAL hazards models, COMORBIDITY
Abstract

Background: Optimal secondary prevention pharmacotherapy is the cornerstone of post‐acute coronary syndrome (ACS) management. The prognostic impact of not receiving five guideline‐recommended therapies is poorly described. Aim: To ascertain the prognostic significance of suboptimal pharmacotherapy in ACS survivors. Methods: Consecutive patients with ACS from the Melbourne Interventional Group registry who were alive at 30 days following their index percutaneous coronary intervention were included. Patients were divided into three categories based on the number of secondary prevention medications prescribed. The optimal medical therapy (OMT), near‐optimal medical therapy (NMT), suboptimal medical therapy (SMT) groups were prescribed 5, 4 and ≤ 3 medications, respectively. Primary endpoint was long‐term mortality. Cox‐proportional hazard modelling was undertaken to assess independent predictors of survival. Results: Of the 9375 patients included, 5678 (60.6%) received OMT, 2903 (31.0%) received NMT and 794 (8.5%) received SMT. Patients receiving SMT were older, more likely to be female and had higher burden of comorbidities (renal impairment, congestive heart failure, diabetes, peripheral vascular disease; P < 0.01 for all). SMT was associated with higher long‐term mortality at 3.9 ± 2.2 years when compared to NMT and OMT (16.8% vs 10.5% vs 8.2%, P < 0.001). Compared to OMT, SMT was an independent predictor of long‐term mortality (hazard ratio, HR 1.62, 95% confidence interval, CI 1.30–2.02, P < 0.01) while NMT was associated with a clinically significant 14% mortality hazard (HR 1.14, 95% CI 0.97–1.34, P = 0.11). Conclusions: There is a graded long‐term hazard associated with not receiving OMT after an ACS. Improvements in secondary prevention pharmacotherapy models of care are warranted to further decrease the long‐term mortality. [ABSTRACT FROM AUTHOR]

Published
2021
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25. Specere II #149, Specere II #95, Specere II #86

Author

Schlosser, J, Murphy, Alexandra C, Schlosser, J, and Murphy, Alexandra C

Abstract

A catalogue of works accompanying the exhibition "Co-Existence", part of the "Seeing with Animals" conference, Eastern Kentucky University, Richmond, Kentucky, USA, 22-25 March 2017. This co-curated exhibition was organised as part of the Seeing with Animals stream of the Living with Animals conference hosted at Eastern Kentucky University (EKU). The exhibition encouraged discourse and was devoted to key issues surrounding animals and imagery. Both still and moving image were shown from an international selection of artists’ work.

Published
2017

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