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2. Need for operational simplicity and timely disbursal of benefits—a qualitative exploration of the implementation of a direct benefit transfer scheme for persons with tuberculosis in India

Author

Mohan, Malu, Thangaraj, Jeromie W. V., Pandey, Sumit, Sri Lakshmi Priya, G., Arunachalam, Sivavallinathan, Sharma, Rahul, Shewade, Hemant Deepak, Aishwarya, B., Afeeq, K., Khatoon, Afsana, Gokulvijay, B., Sireesha, Gude, Chandra, Kavita, Nandhakumar, S., Samuel, Prince, Nanditha Viswanathan, C., Shanmugasundaram, Devika, Rao, Raghuram, Murhekar, Manoj V., and Jeyashree, Kathiresan

Published
2024
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3. Direct benefit transfer for nutritional support of patients with TB in India—analysis of national TB program data of 3.7 million patients, 2018–2022

Author

Jeyashree, Kathiresan, Shanmugasundaram, Prema, Shanmugasundaram, Devika, Priya G, Sri Lakshmi, Thangaraj, Jeromie W V, TS, Sumitha, Pandey, Sumit, Ramasamy, Sabarinathan, Sharma, Rahul, Arunachalam, Sivavallinathan, Shah, Vaibhav, Janagaraj, Venkateshprabhu, Sundari S, Sivakami, Chadwick, Joshua, Shewade, Hemant Deepak, Chowdhury, Aniket, Iyer, Swati, Rao, Raghuram, Mattoo, Sanjay K, and Murhekar, Manoj V

Published
2024
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4. Rubella immunity among pregnant women and the burden of congenital rubella syndrome (CRS) in India, 2022

Author

Shanmugasundaram, Devika, Viswanathan, Rajlakshmi, Winter, Amy K., Agarwal, Anjoo, Roychowdhury, Bidisha, Muliyil, Divya, Prasad, G.R.V., Pushpalatha, K., Gowda, Mamatha, Singh, Pradibha, Priyasree, J., Bonu, Rajeswari, Jha, Sangam, Kumar Jena, Saubhagya, Jain, Shuchi, Suri, Vanita, Hebbale, Vidyavathi, Jain, Amita, Mary Abraham, Asha, Mishra, Baijayantimala, Kumar Pati, Binod, Biswas, Debasis, Pratkeye, Deepashri, Ashok, M., Singh, Mini P., Dhodapkar, Rahul, Ray, Raja, Gadepalli, Ravishekhar, Ratho, R.K., Rani, Sudha, Shukla, Suruchi, Ali A, Syed, Lakshmi Nag, Vijay, Sabarinathan, R., Saravana Kumar, V., Priya R, Padma, Dwibedi, Bhagirathi, Sapkal, Gajanan, Singh, Himabindu, Singh, Kuldeep, Tiwari, Lokesh, Jain, Manish, Mondal, Nivedita, Sreenivasan, Priya, Mahantesh, S., Verma, Sanjay, Awasthi, Shally, Malik, Shikha, Santhanam, Sridhar, Datta, Supratim, Kumar, Amber, Kant Chowdhary, Bhabesh, Khera, Daisy, Jain, Mahendra, Kumar, Praveen, Pati, Sananda, Tripathi, Shalini, and Murhekar, Manoj

Published
2024
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5. Optimal governance and implementation of vaccination programmes to contain the COVID-19 pandemic

Author

Piraveenan, Mahendra, Sawleshwarkar, Shailendra, Walsh, Michael, Zablotska, Iryna, Bhattacharyya, Samit, Farooqui, Habib Hassan, Bhatnagar, Tarun, Karan, Anup, Murhekar, Manoj, Zodpey, Sanjay, Rao, K. S. Mallikarjuna, Pattison, Philippa, Zomaya, Albert, and Perc, Matjaz

Subjects
Computer Science - Computer Science and Game Theory, Physics - Physics and Society, Quantitative Biology - Populations and Evolution
Abstract

Since the recent introduction of several viable vaccines for SARS-CoV-2, vaccination uptake has become the key factor that will determine our success in containing the COVID-19 pandemic. We argue that game theory and social network models should be used to guide decisions pertaining to vaccination programmes for the best possible results. In the months following the introduction of vaccines, their availability and the human resources needed to run the vaccination programmes have been scarce in many countries. Vaccine hesitancy is also being encountered from some sections of the general public. We emphasize that decision-making under uncertainty and imperfect information, and with only conditionally optimal outcomes, is a unique forte of established game-theoretic modelling. Therefore, we can use this approach to obtain the best framework for modelling and simulating vaccination prioritization and uptake that will be readily available to inform important policy decisions for the optimal control of the COVID-19 pandemic., Comment: 15 pages, 1 figure; published in Royal Society Open Science

Published
2020
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6. Profile of cardiac lesions among laboratory confirmed congenital rubella syndrome (CRS) infants: a nationwide sentinel surveillance, India, 2016–22

Author

Kumar, Praveen, Gupta, Parul Chawla, Munjal, Sanjay, Sankhyan, Naveen, Dash, Nabaneeta, Gupta, Madhu, Sai, Ria, Sharma, Vishaly, Gupta, Neeraj, Vyas, Varuna, Kaushal, Nidhi, Suhanimanasa, Shivanna, Niranjan Hunasanahalli, Kumar P, Prem, John, Deepa, Alexander, Arun, Kasturi, Nirupama, Bethou, Adhisivam, Singh, Varsha, Prasad, Nidhi, Ghosh, Aniruddha, Majumdar, Agniva, Dutta, Shanta, Gunasekaran, Pradeep Kumar, Shanmugasundaram, Devika, Santhanam, Sridhar, Verma, Sanjay, Singh, Kuldeep, Dwibedi, Bhagirathi, Awasthi, Shally, Singh, Himabindu, Sangappa, Mahantesh, Mondal, Nivedita, Sreenivasan, Priya, Saradakutty, Geetha, Malik, Shikha, Jain, Manish, Viswanathan, Rajlakshmi, Sapkal, Gajanan, Tripathi, Shalini, Patel, Bhupeshwari, Jain, Mahendra Kumar, Naganur, Sanjeev Hanumantacharya, Baranwal, Arun, Rohit, Manoj K, Deora, Surender, Sharma, Akhil, Anantharaj, Avinash, Pillai, Lakshmi Sadasivan, Kumar, Amber, Ramasamy, Sabarinathan, Rajendran, Padma Priya, Singh, Mini P., Ratho, Radha Kanta, Nag, Vijaylakshmi, Gadepalli, Ravishekhar, Mishra, Baijayantimala, Som, Tapas Kumar, Jain, Amita, Devara, Sudha Madhuri, Vannavada, Sudha Rani, Munivenkatappa, Ashok, Abraham, Asha Mary, Dhodapkar, Rahul, Ali, Syed, Biswas, Debasis, Pratkeye, Deepashri, Bavdekar, Ashish, Prakash, Jayant, Ray, Jaydeb, and Murhekar, Manoj

Published
2023
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7. Congenital rubella syndrome surveillance in India, 2016–21: Analysis of five years surveillance data

Author

Shanmugasundaram, Devika, Verma, Sanjay, Singh, Kuldeep, Dwibedi, Bhagirathi, Awasthi, Shally, Mahantesh, S., Singh, Himabindu, Santhanam, Sridhar, Mondal, Nivedita, S, Geetha, Sreenivasan, Priya, Malik, Shikha, Jain, Manish, Viswanathan, Rajlakshmi, Tripathi, Shalini, Patel, Bhupeshwari, Sapkal, Gajanan, Sabarinathan, R., Singh, Mini P., Ratho, R.K., Nag, Vijaylakshmi, Gadepalli, Ravishekhar, Som, Tapas Kumar, Mishra, Baijayantimala, Jain, Amita, Ashok, M., Madhuri, Devara Sudha, Rani, V Sudha, Abraham, Asha Mary, John, Deepa, Dhodapkar, Rahul, Syed Ali, A., Biswas, Debasis, Pratyeke, Deepashri, Bavdekar, Ashish, Prakash, Jayant, Singh, Varsha, Prasad, Nidhi, Ray, Jaydeb, Majumdar, Agniva, Dutta, Shanta, Gupta, Nivedita, and Murhekar, Manoj

Published
2023
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8. India's 2021 differentiated TB care guidance: Is it feasible to implement and act upon?

Author

Shewade, Hemant Deepak, Frederick, Asha, Kalyanasundaram, Madhanraj, Ravichandran, Prabhadevi, Lokesh, S., Suma, K.V., Aarthi, S., Kiruthika, G., Chadwick, Joshua, Rajasekar, T. Daniel, Gayathri, K., Vijayaprabha, R., Pathinathan, Delphina Peter, Nivetha, M. Bhavani, Chidambaram, Deiveegan, Pradeep, S. Kiran, Bhatnagar, Tarun, Devika, Shanmugasundaram, Rajkumar, S., Sakthivel, M., Mathavi, T., Vellasamy, S., Rajaprakash, A.R., Ganapathy, S., Sundaralingam, K., Savithri, S., Sudha, G., Balasubramaniam, M., Megala, B., Keerthivasan, S., Arunchandar, V., Mallan, Ganga, Khaleel, A. Muhammed, Anbanantham, K., Natesh, S., Bairavi, V., Krishnamoorthy, K., Hameed, O.M. Rahman Shahul, Sathishkumar, P., Saravanan, P., Illakiyaselvan, P.T., Praveenkumar, S., Murugan, S., Ganeshkumar, K., Manoj, G., Sivaprakasam, A., Sangamithira, G., Chandrika, A., Sacred Selvin, A. Alffer, Ranjini, S.V. Asha, Babu, K. Anand, Arunshankar, V., Selvavinayagam, T.S., Ramachandran, Ranjani, and Murhekar, Manoj V.

Published
2023
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9. Evaluating the effect of measles and rubella mass vaccination campaigns on seroprevalence in India: a before-and-after cross-sectional household serosurvey in four districts, 2018–2020

Author

Murhekar, Manoj V, Gupta, Nivedita, Hasan, Alvira Z, Kumar, Muthusamy Santhosh, Kumar, V Saravana, Prosperi, Christine, Sapkal, Gajanan N, Thangaraj, Jeromie Wesley Vivian, Kaduskar, Ojas, Bhatt, Vaishali, Deshpande, Gururaj Rao, Thankappan, Ullas Padinjaremattathil, Bansal, Avi Kumar, Chauhan, Sanjay L, Grover, Gangandeep Singh, Jain, Arun Kumar, Kulkarni, Ragini N, Sharma, Santanu Kumar, Chaaithanya, Itta K, Kharwal, Sanchit, Mishra, Sunil K, Salvi, Neha R, Sharma, Sandeep, Sarmah, Nilanju P, Sabarinathan, R, Duraiswamy, Augustine, Rani, D Sudha, Kanagasabai, K, Lachyan, Abhishek, Gawali, Poonam, Kapoor, Mitali, Shrivastava, Arpit Kumar, Chonker, Saurabh Kumar, Tilekar, Bipin, Tandale, Babasaheb V, Ahmad, Mohammad, Sangal, Lucky, Winter, Amy, Mehendale, Sanjay M, Moss, William J, and Hayford, Kyla

Published
2022
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10. Effectiveness of BBV152/Covaxin and AZD1222/Covishield vaccines against severe COVID-19 and B.1.617.2/Delta variant in India, 2021: a multi-centric hospital-based case-control study

Author

Bhatnagar, Tarun, Chaudhuri, Sirshendu, Ponnaiah, Manickam, Yadav, Pragya D, Sabarinathan, R, Sahay, Rima R, Ahmed, Faheem, Aswathy, S, Bhardwaj, Pankaj, Bilimale, Anil, Kumar, M Santhosh, Logaraj, M., Narlawar, Uday, Palanivel, C, Patel, Prakash, Rai, Sanjay K, Saxena, Vartika, Singh, Arvind, Thangaraj, Jeromie WV, Agarwal, Ashwini, Alvi, Yasir, Amoghashree, Ashok, P, Babu, Dinesh, Bahurupi, Yogesh, Bhalavi, Sangita, Behera, Priyamadhaba, Biswas, Priyanka Pandit, Charan, Jaykaran, Chauhan, Nishant Kumar, Chetak, KB, Dar, Lalit, Das, Ayan, Deepashree, R, Dhar, Minakshi, Dhodapkar, Rahul, Dipu, TS, Dudeja, Mridu, Dudhmal, Manisha, Gadepalli, Ravisekhar, Garg, Mahendra Kumar, Gayathri, AV, Goel, Akhil Dhanesh, Gowdappa, H Basavana, Guleria, Randeep, Gupta, Manoj Kumar, Islam, Farzana, Jain, Mannu, Jain, Vineet, Jawahar, M Lanord Stanley, Joshi, Rajendra, Kant, Shashi, Kar, Sitanshu Sekhar, Kalita, Deepjyoti, Khapre, Meenakshi, Khichar, Satyendra, Kombade, Sarika Prabhakar, Kohli, Sunil, Kumar, Abhinendra, Kumar, Anil, Kumar, Deepak, Kulirankal, Kiran G, Leela, KV, Majumdar, Triparna, Mishra, Baijayantimala, Misra, Puneet, Misra, Sanjeev, Mohapatra, Prasanta Raghab, Murthy, M Narayana, Nyayanit, Dimpal A, Patel, Manish, Pathania, Monika, Patil, Savita, Patro, Binod Kumar, Jalandra, Ramniwas, Rathod, Pragati, Shah, Naimesh, Shete, Anita, Shukla, Deepak, Shwethashree, M, Sinha, Smita, Sumana, MN, Surana, Ashish, Trikha, Anjan, Tejashree, A, Venkateshan, Mahalingam, Vijaykrishnan, G, Wadhava, Sarita, Wig, Naveet, Gupta, Nivedita, Abraham, Priya, and Murhekar, Manoj V

Published
2022
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11. Safety and immunogenicity of the Rotavac and Rotasiil rotavirus vaccines administered in an interchangeable dosing schedule among healthy Indian infants: a multicentre, open-label, randomised, controlled, phase 4, non-inferiority trial

Author

Kanungo, Suman, Chatterjee, Pranab, Bavdekar, Ashish, Murhekar, Manoj, Babji, Sudhir, Garg, Richa, Samanta, Sandip, Nandy, Ranjan K, Kawade, Anand, Boopathi, Kangusamy, Kanagasabai, Kaliaperumal, Kamal, Vineet Kumar, Kumar, Velusamy Saravana, Gupta, Nivedita, and Dutta, Shanta

Published
2022
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13. Restoration of dendritic cell homeostasis and Type I/Type III interferon levels in convalescent COVID-19 individuals

Author

Rajamanickam, Anuradha, Kumar, Nathella Pavan, Pandiaraj, Arul Nancy, Selvaraj, Nandhini, Munisankar, Saravanan, Renji, Rachel Mariam, Venkatramani, Vijayalakshmi, Murhekar, Manoj, Thangaraj, Jeromie Wesley Vivian, Kumar, Muthusamy Santhosh, Kumar, Chethrapilly Purushothaman Girish, Bhatnagar, Tarun, Ponnaiah, Manickam, Sabarinathan, Ramasamy, Saravanakumar, Velusamy, and Babu, Subash

Published
2022
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15. Analysis of Cholera Risk in India: Insights from 2017–18 Serosurvey Data Integrated with Epidemiologic data and Societal Determinants from 2015–2019.

Author

Kanungo, Suman, Nandy, Ranjan Kumar, Talukdar, Rounik, Murhekar, Manoj, Azman, Andrew S., Hegde, Sonia T., Chatterjee, Pranab, Chakraborty, Debjit, Das, Madhuchhanda, Kamaraj, P, Kumar, Muthusamy Santhosh, and Dutta, Shanta

Subjects
CHOLERA, VIBRIO cholerae, TASK forces, DEVELOPING countries, SANITATION, RISK assessment
Abstract

Background: Indian subcontinent being an important region in the fight to eliminate cholera needs better cholera surveillance. Current methods miss most infections, skewing disease burden estimates. Triangulating serosurvey data, clinical cases, and risk factors could reveal India's true cholera risk. Methods: We synthesized data from a nationally representative serosurvey, outbreak reports and risk factors like water, sanitation and the Multidimensional Poverty Index, to create a composite vulnerability index for assessing state-wise cholera risk in India. We tested 7,882 stored sera samples collected during 2017–18 from individuals aged 9–45 years, for vibriocidal antibodies to Vibrio cholerae O1 using a cut-off titre ≥320 defining as elevated titre. We also extracted data from the 2015–19 Integrated Disease Surveillance Programme and published cholera reports. Results: Overall, 11.7% (CI: 10.4–13.3%) of the sampled population had an elevated titre of cholera vibriocidal antibodies (≥320). The Southern region experienced the highest incidence (16.8%, CI: 12.1–22.8), followed by the West (13.2%, CI: 10.0–17.3) and North (10.7%, CI: 9.3–12.3). Proportion of samples with an elevated vibriocidal titre (≥320) was significantly higher among individuals aged 18–45 years (13.0% CI: 11.2–15.1) compared to children 9–17 years (8.6%, CI 7.3–10.0, p<0.05); we found no differences between sex or urbanicity. Between 2015–2019, the Integrated Disease Surveillance Program (IDSP) reported 29,400 cases of cholera across the country. Using the composite vulnerability index, we found Karnataka, Madhya Pradesh, and West Bengal were the most vulnerable states in India in terms of risk of cholera. Conclusion: The present study showed that cholera infection is present in all five regions across India. The states with high cholera vulnerability could be prioritized for targeted prevention interventions. Author summary: Cholera remains a significant public health threat in areas with inadequate water, sanitation, and hygiene (WASH). The World Health Organization's Global Task Force on Cholera Control (GTFCC) launched "Ending Cholera: A Global Roadmap to 2030" to reduce cholera deaths and eliminate the disease in 20 countries by 2030 through targeted interventions, including improved WASH practices and disease surveillance. cholera surveillance, especially in developing countries seldom poses difficulty in terms of the need for laboratory infrastructure, and other resource constraints. Thereby, in this study, we utilized a viable approach with serosurvey data from 2017, cholera outbreak data, WASH indicators, and the Multidimensional Poverty Index (MPI) to create a composite vulnerability index for cholera risk in India. Overall, 11.7% of the sampled population had detectable levels of cholera antibodies reflecting previous infection. The Southern region of India experienced the highest incidence, followed by the West and North. the study showed that cholera infection is present in all five regions across India. Further, the vulnerability index which we built could be utilized in other settings so that effective tailored interventions could be applied in identified priority areas. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Lessons Learned From a Peer-Supported Differentiated Care and Nutritional Supplementation for People With TB in a Southern Indian State.

Author

Shewade, Hemant Deepak, Jeyakumar Jaisingh, A. James, Ravichandran, Prabhadevi, Pradeep, S. Kiran, Pandurangan, Sripriya, Mohanty, Subrat, Rajasekar, T. Daniel, Vijayaprabha, R., Kiruthika, G., Suma, K. V., Pathinathan, Delphina Peter, Chidambaram, Deiveegan, Sivagami, K., Srinivasan, Anupama, Swamickan, Reuben, Goswami, Amrita, Sivaranjani, D., Ananthakrishnan, Ramya, Frederick, Asha, and Murhekar, Manoj V.

Published
2024
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17. Outbreak of ceftriaxone-resistant Salmonella enterica serotype Typhi-Tiruchirappalli, Tamil Nadu, India, June 2018

Author

Dzeyie, Kevisetuo A., Dhanapaul, Sankara, Rubeshkumar, Polani, Desing, SaravanaKumar, Vignesh, M S, Raveendran, I, Kumar, Prem, Kathuria, Shallu, Choudhary, Sushma, Saroha, Ekta, Siromany, Valan, Raju, Mohankumar, Ganeshkumar, Parasuraman, Ponnaiah, Manickam, Sodha, Samir V., Laserson, Kayla, Bhatnagar, Tarun, Kapoor, Lata, Bahl, Arti, Jain, Sudhir K, Gupta, Sunil, Murhekar, Manoj V, and Singh, Sujeet K

Published
2021
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19. Triaging for Severe Illness amongst Adults with Tuberculosis Followed by Referral and Inpatient Care: A Statewide Pilot in Tamil Nadu, India

Author

Shewade, Hemant D., primary, Frederick, Asha, additional, Kalyanasundaram, Madhanraj, additional, Chadwick, Joshua, additional, Kiruthika, G, additional, Rajasekar, T Daniel, additional, Gayathri, K, additional, Vijayaprabha, R, additional, Sabarinathan, R, additional, Shivakumar, Shri Vijay Bala Yogendra, additional, Jeyashree, Kathiresan, additional, Bhavani, P K, additional, Aarthi, S, additional, Suma, K V, additional, Pathinathan, Delphina P., additional, Parthasarathy, Raghavan, additional, Nivetha, M Bhavani, additional, Thampi, Jerome G, additional, Chidambaram, Deiveegan, additional, Bhatnagar, Tarun, additional, Lokesh, S, additional, Devika, Shanmugasundaram, additional, Laux, Timothy S., additional, Viswanathan, Stalin, additional, Sridhar, R, additional, Krishnamoorthy, K, additional, Sakthivel, M, additional, Karunakaran, S, additional, Rajkumar, S, additional, Ramachandran, M., additional, Kanagaraj, K D, additional, Durai, V P, additional, Saravanan, R, additional, Sugantha, A, additional, Khan, S Zufire Hassan Mohamed, additional, Sangeetha, P, additional, Vasudevan, R, additional, Nedunchezhian, R, additional, Sankari, M, additional, Jeevanandam, N, additional, Ganapathy, S, additional, Rajasekaran, V, additional, Mathavi, T, additional, Rajaprakash, A R, additional, Murali, Lakshmi, additional, Pugal, U, additional, Sundaralingam, K, additional, Savithri, S, additional, Vellasamy, S, additional, Dheenadayal, D, additional, Ashok, P, additional, Sudhakar, R, additional, Rajan, K P, additional, Tharageshwari, N, additional, Chokkalingam, D, additional, Anandrajkumar, S M, additional, Selvavinayagam, T S, additional, Padmapriyadarshini, C, additional, Ramachandran, Ranjani, additional, and Murhekar, Manoj V, additional

Published
2024
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21. SARS-CoV-2 seroprevalence among the general population and healthcare workers in India, December 2020–January 2021

Author

Anand, Tanu, Babu, Giridhara R., Chauhan, Himanshu, Dikid, Tanzin, Gangakhedkar, Raman R., Kant, Shashi, Kulkarni, Sanket, Muliyil, J.P., Pandey, Ravindra Mohan, Sarkar, Swarup, Shah, Naman, Shrivastava, Aakash, Singh, Sujeet K., Zodpe, Sanjay, Hindupur, Anusha, Asish, P.R., Chellakumar, M., Chokkalingam, D., Dasgupta, Sauvik, Gowtham, M.M.E., Jose, Annamma, Kalaiyarasi, K., Karthik, N.N., Karunakaran, T., Kiruthika, G., Dinesh Kumar, H., Sarath Kumar, S., Sarath Kumar, M.P., Michaelraj, E., Pradhan, Josephine, Arun Prasath, E.B., Gladys Angelin Rachel, D., Rani, Sudha, Rozario, Amanda, Sivakumar, R., Gnana Soundari, P., Sujeetha, K., Vinod, Arya, Murhekar, Manoj V., Bhatnagar, Tarun, Thangaraj, Jeromie Wesley Vivian, Saravanakumar, V., Kumar, Muthusamy Santhosh, Selvaraju, Sriram, Rade, Kiran, Kumar, C.P. Girish, Sabarinathan, R., Turuk, Alka, Asthana, Smita, Balachandar, Rakesh, Bangar, Sampada Dipak, Bansal, Avi Kumar, Chopra, Vishal, Das, Dasarathi, Deb, Alok Kumar, Devi, Kangjam Rekha, Dhikav, Vikas, Dwivedi, Gaurav Raj, Khan, S. Muhammad Salim, Kumar, M. Sunil, Laxmaiah, Avula, Madhukar, Major, Mahapatra, Amarendra, Rangaraju, Chethana, Turuk, Jyotirmayee, Yadav, Rajiv, Andhalkar, Rushikesh, Arunraj, K., Bharadwaj, Dinesh Kumar, Bharti, Pravin, Bhattacharya, Debdutta, Bhat, Jyothi, Chahal, Ashrafjit S., Chakraborty, Debjit, Chaudhury, Anshuman, Deval, Hirawati, Dhatrak, Sarang, Dayal, Rakesh, Elantamilan, D., Giridharan, Prathiksha, Haq, Inaamul, Hudda, Ramesh Kumar, Jagjeevan, Babu, Kalliath, Arshad, Kanungo, Srikanta, Krishnan, Nivethitha N., Kshatri, Jaya Singh, Kumar, Alok, Kumar, Niraj, Kumar, V.G. Vinoth, Lakshmi, G.G.J. Naga, Mehta, Ganesh, Mishra, Nandan Kumar, Mitra, Anindya, Nagbhushanam, K., Nimmathota, Arlappa, Nirmala, A.R., Pandey, Ashok Kumar, Prasad, Ganta Venkata, Qurieshi, Mariya Amin, Reddy, Sirasanambatti Devarajulu, Robinson, Aby, Sahay, Seema, Saxena, Rochak, Sekar, Krithikaa, Shukla, Vijay Kumar, Singh, Hari Bhan, Singh, Prashant Kumar, Singh, Pushpendra, Singh, Rajeev, Srinivasan, Nivetha, Varma, Dantuluri Sheethal, Viramgami, Ankit, Wilson, Vimith Cheruvathoor, Yadav, Surabhi, Yadav, Suresh, Zaman, Kamran, Chakrabarti, Amit, Das, Aparup, Dhaliwal, R.S., Dutta, Shanta, Kant, Rajni, Khan, A.M., Narain, Kanwar, Narasimhaiah, Somashekar, Padmapriyadarshini, Chandrasekaran, Pandey, Krishna, Pati, Sanghamitra, Patil, Shripad, Rajkumar, Hemalatha, Ramarao, Tekumalla, Sharma, Y.K., Singh, Shalini, Panda, Samiran, Reddy, D.C.S., and Bhargava, Balram

Published
2021
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22. Immunity against diphtheria among children aged 5–17 years in India, 2017–18: a cross-sectional, population-based serosurvey

Author

Karunakaran, T, Govindhasamy, C, Daniel Rajasekar, T, Jeyakumar, A, Suresh, A, Augustine, D, Ashok Kumar, P, Jose, Annamma, Sivakumar, R, Banerjee John, JW, Murhekar, Manoj V, Kamaraj, Pattabi, Kumar, Muthusamy Santhosh, Khan, Siraj Ahmed, Allam, Ramesh Reddy, Barde, Pradip V, Dwibedi, Bhagirathi, Kanungo, Suman, Mohan, Uday, Mohanty, Suman Sundar, Roy, Subarna, Sagar, Vivek, Savargaonkar, Deepali, Tandale, Babasaheb V, Topno, Roshan Kamal, Kumar, C P Girish, Sabarinathan, Ramasamy, Bitragunta, Sailaja, Grover, Gagandeep Singh, Lakshmi, P V M, Mishra, Chandra Mauli, Sadhukhan, Provash, Sahoo, Prakash Kumar, Singh, Shivendra Kumar, Yadav, Chander Prakash, Kumar, Rajesh, Dutta, Shanta, Toteja, G S, Gupta, Nivedita, and Mehendale, Sanjay M

Published
2021
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25. SARS-CoV-2 antibody seroprevalence in India, August–September, 2020: findings from the second nationwide household serosurvey

Author

Andhalkar, Rushikesh, Chaudhury, Anshuman, Deval, Hirawati, Dhatrak, Sarang, Gupta, Rajeev Ranjan, Ilayaperumal, Ezhilarasan, Jagjeevan, Babu, Jha, Ramesh Chandra, Kiran, K, Krishnan, Nivethitha N, Kumar, Alok, Kumar, VG Vinoth, Nagbhushanam, K, Nimmathota, Arlappa, Pandey, Ashok Kumar, Pawar, Harpreet Singh, Rathore, Kushal Singh, Robinson, Aby, Singh, Hari Bhan, Wilson, Vimith Cheruvathoor, Yadav, Ashwini, Yadav, Rajiv, Karunakaran, T, Pradhan, Josephine, Sivakumar, T, Jose, Annamma, Kalaiyarasi, K, Dasgupta, Sauvik, Anusha, R, Anand, Tanu, Babu, Giridhara R, Chauhan, Himanshu, Dikid, Tanzin, Gangakhedkar, Raman R, Kant, Shashi, Kulkarni, Sanket, Muliyil, J P, Pandey, Ravindra Mohan, Sarkar, Swarup, Shrivastava, Aakash, Singh, Sujeet K, Zodpey, Sanjay, Das, Aparup, Das, Pradeep, Dutta, Shanta, Kant, Rajni, Narain, Kanwar, Narasimhaiah, Somashekar, Pati, Sanghamitra, Patil, Shripad, Rajkumar, Hemalatha, Ramarao, Tekumalla, Sarkar, Kamalesh, Singh, Shalini, Toteja, Gurudayal S, Zaman, Kamran, Murhekar, Manoj V, Bhatnagar, Tarun, Selvaraju, Sriram, Saravanakumar, V, Thangaraj, Jeromie Wesley Vivian, Shah, Naman, Kumar, Muthusamy Santhosh, Rade, Kiran, Sabarinathan, R, Asthana, Smita, Balachandar, Rakesh, Bangar, Sampada Dipak, Bansal, Avi Kumar, Bhat, Jyothi, Chopra, Vishal, Das, Dasarathi, Deb, Alok Kumar, Devi, Kangjam Rekha, Dwivedi, Gaurav Raj, Khan, S Muhammad Salim, Kumar, C P Girish, Kumar, M Sunil, Laxmaiah, Avula, Madhukar, Major, Mahapatra, Amarendra, Mohanty, Suman Sundar, Rangaraju, Chethana, Turuk, Alka, Baradwaj, Dinesh Kumar, Chahal, Ashrafjit S, Debnath, Falguni, Haq, Inaamul, Kalliath, Arshad, Kanungo, Srikanta, Kshatri, Jaya Singh, Lakshmi, G G J Naga, Mitra, Anindya, Nirmala, A R, Prasad, Ganta Venkata, Qurieshi, Mariya Amin, Sahay, Seema, Sangwan, Ramesh Kumar, Sekar, Krithikaa, Shukla, Vijay Kumar, Singh, Prashant Kumar, Singh, Pushpendra, Singh, Rajeev, Varma, Dantuluri Sheethal, Viramgami, Ankit, Panda, Samiran, Reddy, D C S, and Bhargava, Balram

Published
2021
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27. Population-Based Serosurvey for Severe Acute Respiratory Syndrome Coronavirus 2 Transmission, Chennai, India

Author

Selvaraju, Sriram, Kumar, Muthusamy Santhosh, Thangaraj, Jeromie Wesley Vivian, Bhatnagar, Tarun, Saravanakumar, Velusamy, Kumar, Chethrapilly Purushothaman Girish, Sekar, Krithikaa, Ilayaperumal, Ezhilarasan, Sabarinathan, Ramasamy, Jagadeesan, Murugesan, Hemalatha, Masanam Sriramulu, and Murhekar, Manoj Vasant

Subjects
Sentinel health events -- Methods, Disease transmission -- Models, Immunoglobulin G -- Identification and classification, Health
Abstract

On August 15, 2020, India had the third highest number of coronavirus disease (COVID-19) cases globally (1). The Indian state of Tamil Nadu reported 332,105 cases and 5,641 deaths on [...]

Published
2021
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28. Hepatitis-B virus infection in India: Findings from a nationally representative serosurvey, 2017-18

Author

Karunakaran, T., Jose, Annamma, Augustine, D., Govindhasamy, C., Daniel Rajasekar, T., Jeyakumar, A., Suresh, A., Ashok Kumar, P., Sivakumar, R., Banerjee John, J.W., Murhekar, Manoj V., Santhosh Kumar, Muthusamy, Kamaraj, P., Khan, Siraj Ahmed, Allam, Ramesh Reddy, Barde, Pradip, Dwibedi, Bhagirathi, Kanungo, Suman, Mohan, Uday, Mohanty, Suman Sundar, Roy, Subarna, Sagar, Vivek, Savargaonkar, Deepali, Tandale, Babasaheb V., Topno, Roshan Kamal, Girish Kumar, C.P., Sabarinathan, R., Bitragunta, Sailaja, Grover, Gagandeep Singh, Lakshmi, P.V.M., Mishra, Chandra Mauli, Sadhukhan, Provash, Sahoo, Prakash Kumar, Singh, S.K., Yadav, Chander Prakash, Kumar, Rajesh, Dutta, Shanta, Toteja, G.S., Gupta, Nivedita, and Mehendale, Sanjay M.

Published
2020
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29. Association between COVID-19 Vaccination (ChAdOx1-S) and Thromboembolic, Thrombocytopenic, Hemorrhagic Events: A Systematic Review and Meta-analysis of Analytical Epidemiological Studies.

Author

Vaman, Raman S., Kumar, Muthusamy S., Jeyashree, Kathiresan, Periasami, Ashok, Abdulkader, Rizwan S., and Murhekar, Manoj

Subjects
IMMUNIZATION, MEDICAL information storage & retrieval systems, CEREBRAL embolism & thrombosis, VEINS, VENOUS thrombosis, COVID-19 vaccines, META-analysis, DESCRIPTIVE statistics, THROMBOCYTOPENIA, SYSTEMATIC reviews, MEDLINE, THROMBOEMBOLISM, ADVERSE health care events, CONFIDENCE intervals, HEMORRHAGE, DISEASE risk factors
Abstract

We conducted a systematic review of analytical epidemiological studies to assess the association between ChAdOx1-S vaccination and thromboembolic, thrombocytopenic, and hemorrhagic events. We searched Medline, Embase, Google Scholar, WHO-COVID-19 database, and medRxiv for studies evaluating the association between ChAdOx1-S and vascular events. Primary outcomes of interest were cerebral venous sinus thrombosis, peripheral venous thrombosis (PVT), and thrombocytopenia. Two independent reviewers screened for eligible studies, extracted data, and assessed the risk of bias. The DerSimonian-Laird random effects model was used to pool the incidence rate ratios (IRRs) separately for the first and second doses. Heterogeneity was assessed using I2 statistics. Twenty studies were included, of which 11 were self-controlled case series, and nine were cohort studies (254 million participants). Pooling of 17 studies showed a higher risk of cerebrovascular thrombosis (IRR = 3.5, 95% CI = 2.2-5.4, I² = 79%), PVT (IRR = 2.0, 95% CI = 1.1-3.5, I² = 95%) and thrombocytopenia (IRR = 1.6, 95% CI = 1.4-1.9, I² = 93%) among those who received ChAdOx1-S vaccination as compared to controls. No increased risk was seen after the second dose or for secondary outcomes. There is moderate-to-high certainty of the evidence for the increased risk of cerebral venous sinus thrombosis, PVT, and thrombocytopenia following the first dose of the ChAdOx1-S vaccine. Systematic Review Registration: PROSPERO CRD42022372768. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Baseline findings of a multicentric ambispective cohort study (2021–2022) among hospitalised mucormycosis patients in India

Author

Abdulkader, Rizwan Suliankatchi, primary, Ponnaiah, Manickam, additional, Bhatnagar, Tarun, additional, S, Devika, additional, Rozario, Amanda G.A, additional, K, Gayathri, additional, Mohan, Malu, additional, E, Michaelraj, additional, Saravanakumar, Divya, additional, Moorthy, Aditya, additional, Tyagi, Amit Kumar, additional, Parmar, Bhagirathsinh D, additional, Devaraja, K, additional, Medikeri, Gaurav, additional, Ojah, Jutika, additional, Srivastava, Kajal, additional, K, Karthikeyan, additional, Das, Nandini, additional, B, Niharika, additional, Sharma, Parul, additional, Kumar Parida, Pradipta, additional, Kumar Saravanam, Prasanna, additional, Kulkarni, Praveen, additional, S, Priya, additional, Patil S, Pushpa, additional, Kumar Bagla, Rahul, additional, D, Ramesh, additional, S Melkundi, Renuka, additional, S Satpute, Satish, additional, Narayanan, Seetharaman, additional, Jahagirdar, Shubhashri, additional, Dube, Simmi, additional, Kumar Panigrahi, Sunil, additional, Babu D, Surendra, additional, Saini, Vaibhav, additional, Singh Saxena, Rita, additional, Srivastava, Abhinav, additional, Chandra Baishya, Achyut, additional, Garg, Ajai, additional, Kumar Mishra, Amit, additional, Jyoti Talukdar, Anjan, additional, Kankaria, Ankita, additional, Karat, Arathi, additional, Sundaresh Kumar, Arul, additional, Chug, Ashi, additional, Vankundre, Ashok, additional, Ramaswamy, Balakrishnan, additional, MB, Bharathi, additional, R Jadav, Bhargav, additional, Dhiwakar, Muthuswamy, additional, Ghate, Girija, additional, Shah, Hardik V, additional, Saha, Ipsita, additional, Sivapuram, Kavya, additional, J Joshi, Krupal, additional, Singh, Mahendra, additional, Chand Bairwa, Mukesh, additional, K, Divya, additional, E, Muthurajesh, additional, Samagh, Navneh, additional, Dinakaran, Nethra, additional, Gupta, Nikhil, additional, Gupta, Nitin, additional, M Nagarkar, Nitin, additional, Solanki, Nitin, additional, Kumar Panda, Prasan, additional, Bachalli, Prithvi, additional, Shanbag, Raghunath, additional, Patil, Rajashri, additional, Kumar A, Rajesh, additional, Narayan Patil, Rakesh, additional, Thookkanaickenpalayam Vijayaraghavan, Ramanikanth, additional, Hanumantappa, Ramesh, additional, A, Rathinavel, additional, Mandal, Saleel Kumar, additional, Kishve, Sanjay Pandharinath, additional, Varghese Thomas, Sara, additional, Sarkar, Saurav, additional, Thakur, Shalini, additional, Patil, Siddaram, additional, Lakshmanan, Somu, additional, D Rao, Srinivas, additional, V, Sumathi, additional, Nayak, Tulasi, additional, Dixit, Umesh R, additional, B, Unnikrishnan, additional, Backiavathy, Varsha, additional, Shenoy, Vijendra, additional, Hallur, Vinay Kumar, additional, Bhatnagar, Aparna, additional, and Murhekar, Manoj V, additional

Published
2024
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31. Interplay of missed opportunity for vaccination and poor response to the vaccine led to measles outbreak in a slum area of Eastern Mumbai, India

Author

Yadav, Reetika Malik, primary, Gomare, Mangala, additional, Gaikwad, Arun, additional, Waghmare, Upalimitra, additional, Betodkar, Utkarsh, additional, Vashi, Meeta Dhaval, additional, Kamal, Vineet Kumar, additional, Thangaraj, Jeromie Wesley Vivian, additional, Bangar, Sampada, additional, Bhatnagar, Tarun, additional, and Murhekar, Manoj, additional

Published
2024
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32. Neutralizing antibody responses to SARS-CoV-2 Omicron variants: Post six months following two-dose & three-dose vaccination of ChAdOx1 nCoV-19 or BBV152

Author

Sapkal, GajananN, primary, Yadav, PragyaD, additional, Sardana, Viren, additional, Deshpande, GururajRao, additional, Shinde, PradnyaV, additional, Vivian Thangaraj, JeromieWesley, additional, George, LeyannaS, additional, Patil, DeepakY, additional, Sahay, RimaR, additional, Shete, AnitaM, additional, Joshi, Madhavi, additional, Murhekar, Manoj, additional, Godbole, Sheela, additional, Gupta, Nivedita, additional, Prakash, Satyartha, additional, Rathore, Mamta, additional, Ujjainiya, Rajat, additional, Singh, AjayPratap, additional, Mishra, Aastha, additional, Dash, Debasis, additional, Chaudhary, Kumardeep, additional, and Sengupta, Shantanu, additional

Published
2024
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34. Dynamic alterations in monocyte numbers, subset frequencies and activation markers in acute and convalescent COVID-19 individuals

Author

Rajamanickam, Anuradha, Kumar, Nathella Pavan, Pandiarajan, Arul Nancy, Selvaraj, Nandhini, Munisankar, Saravanan, Renji, Rachel Mariam, Venkatramani, Vijayalakshmi, Murhekar, Manoj, Thangaraj, Jeromie W. V., Kumar, Muthusamy Santhosh, Kumar, C. P. Girish, Bhatnagar, Tarun, Ponnaiah, Manickam, Sabarinathan, R., Saravanakumar, V., and Babu, Subash

Published
2021
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35. Burden of dengue infection in India, 2017: a cross-sectional population based serosurvey

Author

Murhekar, Manoj V, Kamaraj, P, Kumar, Muthusamy Santhosh, Khan, Siraj Ahmed, Allam, Ramesh Reddy, Barde, Pradip, Dwibedi, Bhagirathi, Kanungo, Suman, Mohan, Uday, Mohanty, Suman Sundar, Roy, Subarna, Sagar, Vivek, Savargaonkar, Deepali, Tandale, Babasaheb V, Topno, Roshan Kamal, Sapkal, Gajanan, Kumar, C P Girish, Sabarinathan, R, Kumar, Velusamy Saravana, Bitragunta, Sailaja, Grover, Gagandeep Singh, Lakshmi, P V M, Mishra, Chandra Mauli, Sadhukhan, Provash, Sahoo, Prakash Kumar, Singh, S K, Yadav, Chander Prakash, Bhagat, Asha, Srivastava, Rashi, Dinesh, E Ramya, Karunakaran, T, Govindhasamy, C, Rajasekar, T Daniel, Jeyakumar, A, Suresh, A, Augustine, D, Kumar, P Ashok, Kumar, Rajesh, Dutta, Shanta, Toteja, G S, Gupta, Nivedita, and Mehendale, Sanjay M

Published
2019
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37. Comparison of two commercial ELISA kits for detection of rubella specific IgM in suspected congenital rubella syndrome cases and rubella IgG antibodies in a serosurvey of pregnant women

Author

Viswanathan, Rajlakshmi, George, Suji, Murhekar, Manoj V, Abraham, Asha Mary, Singh, Mini P, Jadhav, Santoshkumar M, Nag, Vijayalakshmi, Naik, Sadanand, Raut, Chandrashekhar, Munivenkatappa, Ashok, Gupta, Minakshi, Jagtap, Vishal, Kaduskar, Ojas, Gupta, Nivedita, and Sapkal, Gajanan N

Published
2019
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38. Quality of active case-finding for tuberculosis in India: a national level secondary data analysis

Author

Shewade, Hemant Deepak, primary, Kiruthika, G., additional, Ravichandran, Prabhadevi, additional, Iyer, Swati, additional, Chowdhury, Aniket, additional, Kiran Pradeep, S., additional, Jeyashree, Kathiresan, additional, Devika, S., additional, Chadwick, Joshua, additional, Wesley Vivian, Jeromie, additional, Tumu, Dheeraj, additional, Shah, Amar N., additional, Vadera, Bhavin, additional, Roddawar, Venkatesh, additional, Mattoo, Sanjay K., additional, Rade, Kiran, additional, Rao, Raghuram, additional, and Murhekar, Manoj V., additional

Published
2023
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40. Low Prevalence of Soil-Transmitted Helminth Infections among Children in the States of Chhattisgarh and Himachal Pradesh, India, 2018

Author

Campbell, Suzy J., primary, Shanmugasundaram, Devika, additional, Ganguly, Sandipan, additional, Sehgal, Rakesh, additional, Karmakar, Sumallya, additional, Sanga, Prerna, additional, Stephen, Hannah Nirmala, additional, Kaur, Hargobinder, additional, Kihara, Jimmy, additional, Minnery, Mark, additional, Nath, Srabani, additional, Sen, Shrabanti, additional, Bundy, Donald A., additional, Mishra, Neeraj, additional, Batra, Gunjan, additional, Shah, Hemang, additional, Balasubramaniam, Sudharsunam, additional, Dutta, Shanta, additional, Khera, Ajay, additional, and Murhekar, Manoj, additional

Published
2023
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41. Protocol for establishing a model for integrated influenza surveillance in Tamil Nadu, India

Author

Abdulkader, Rizwan S., primary, Potdar, Varsha, additional, Mohd, Gulam, additional, Chadwick, Joshua, additional, Raju, Mohan Kumar, additional, Devika, S., additional, Bharadwaj, Sumit Dutt, additional, Aggarwal, Neeraj, additional, Vijay, Neetu, additional, Sugumari, C., additional, Sundararajan, T., additional, Vasuki, V., additional, Bharathi Santhose, N., additional, Mohammed Razik, C. A., additional, Madhavan, Vinoth, additional, Krupa, N. C., additional, Prabakaran, Nandhini, additional, Murhekar, Manoj V., additional, and Gupta, Nivedita, additional

Published
2023
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42. Sentinel Surveillance for Congenital Rubella Syndrome — India, 2016–2017

Author

Murhekar, Manoj, Bavdekar, Ashish, Benakappa, Asha, Santhanam, Sridhar, Singh, Kuldeep, Verma, Sanjay, Sapkal, Gajanan N., Gupta, Nivedita, Verghese, Valsan Philip, Viswanathan, Rajlakshmi, Abraham, Asha Mary, Choudhary, Shyama, Deshpande, Gururajrao N., George, Suji, Goyal, Garima, Gupta, Parul Chawla, Jhamb, Ishani, John, Deepa, Philip, Swetha, Kadam, Sandeep, Sachdeva, Ravinder Kaur, Kumar, Praveen, Lepcha, Anjali, Mahantesh, S., Manasa, S., Nehra, Urvashi, Munjal, Sanjay Kumar, Nag, Vijaya Lakshmi, Naik, Sadanand, Raj, Naga, Ram, Jagat, Ratho, R.K., Raut, C.G., Rohit, Manoj Kumar, Sabarinathan, R., Shah, Sanjay, Singh, Pratibha, Singh, Mini P., Tiwari, Ashish, and Vaid, Neelam

Published
2018

45. Infections among Contacts of Patients with Nipah Virus, India

Author

Kumar, C.P. Girish, Sugunan, Attayur P., Yadav, Pragya, Kurup, Karishma Krishna, Aarathee, Renjith, Manickam, Ponnaiah, Bhatnagar, Tarun, Radhakrishnan, Chandni, Thomas, Bina, Kumar, Akhilesh, Jayasree, V., Jose, Beena Philomina, Kumar, K.G. Sajeeth, Thulaseedharan, N.K., Gupta, Nivedita, Rajendran, V.R., Saritha, R.L., Mourya, Devendra T., Gangakhedkar, Raman R., and Murhekar, Manoj V.

Subjects
Bats (Animals), Marburg virus disease, Infection, Medical personnel, Zoonoses, Immunoglobulin G, Swine, Health
Abstract

Nipah virus (NiV) infection is an emerging zoonotic disease that has the potential to cause severe disease in both animals and humans (1). Fruit bats of the Ptempus genus (family [...]

Published
2019
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46. Rapid assessment of coverage of doxycycline/azithromycin chemoprophylaxis against leptospirosis following floods, Kozhikode district, Kerala, 2018.

Author

Sasikumar, Harishankar, Ganeshkumar, Parasuraman, R, Sabarinathan, Rubeshkumar, Polani, Venkatasamy, Vettrichelvan, and Murhekar, Manoj

Subjects
CHEMOPREVENTION, LEPTOSPIROSIS, DOXYCYCLINE, AZITHROMYCIN, CONSCIOUSNESS raising
Abstract

Background We estimated coverage of doxycycline chemoprophylaxis (200 mg once weekly) following floods in Kerala, India. Methods A cross-sectional survey was conducted to gather data on exposure to flood or stagnant water and receipt and consumption of chemoprophylaxis. Results Of 1573 individuals interviewed, 152 (10%) were exposed to flood water. Among these, 119 (78%) were eligible for chemoprophylaxis. Of those eligible, 58 (38.2% [95% confidence interval 30.8 to 46.1]) reported consuming the prescribed chemoprophylaxis. Conclusions Despite the availability of chemoprophylaxis, consumption was less than ideal. We recommend targeted interventions to improve chemoprophylaxis coverage and public awareness campaigns to enhance its consumption among the affected population. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Risk Factors for Acquiring Scrub Typhus among Children in Deoria and Gorakhpur Districts, Uttar Pradesh, India, 2017

Author

Thangaraj, Jeromie Wesley Vivian, Vasanthapuram, Ravi, Machado, Leonard, Arunkumar, Govindakarnavar, Sodha, Samir V., Zaman, Kamran, Bhatnagar, Tarun, Hameed, Shafeeq K. Shahul, Kumar, Arun, Abdulmajeed, Jazeel, Velayudhan, Anoop, Deoshatwar, Avinash, Desai, Anita S., Kumar, K. Hemanth, Gupta, Nivedita, Laserson, Kayla, and Murhekar, Manoj

Subjects
Uttar Pradesh, India -- Health aspects, Children -- Health aspects, Risk assessment -- Analysis, Scrub typhus -- Risk factors -- Research, Health
Abstract

Outbreaks of acute encephalitis syndrome (AES) with high case-fatality rates have been reported from Gorakhpur district, Uttar Pradesh, India, for >2 decades. These outbreaks occur during monsoon and postmonsoon seasons [...]

Published
2018
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48. Nations within a nation: variations in epidemiological transition across the states of India, 1990–2016 in the Global Burden of Disease Study

Author

Dandona, Lalit, Dandona, Rakhi, Kumar, G Anil, Shukla, D K, Paul, Vinod K, Balakrishnan, Kalpana, Prabhakaran, Dorairaj, Tandon, Nikhil, Salvi, Sundeep, Dash, A P, Nandakumar, A, Patel, Vikram, Agarwal, Sanjay K, Gupta, Prakash C, Dhaliwal, R S, Mathur, Prashant, Laxmaiah, Avula, Dhillon, Preet K, Dey, Subhojit, Mathur, Manu R, Afshin, Ashkan, Fitzmaurice, Christina, Gakidou, Emmanuela, Gething, Peter, Hay, Simon I, Kassebaum, Nicholas J, Kyu, Hmwe, Lim, Stephen S, Naghavi, Mohsen, Roth, Gregory A, Stanaway, Jeffrey D, Whiteford, Harvey, Chadha, Vineet K, Khaparde, Sunil D, Rao, Raghuram, Rade, Kirankumar, Dewan, Puneet, Furtado, Melissa, Dutta, Eliza, Varghese, Chris M, Mehrotra, Ravi, Jambulingam, P, Kaur, Tanvir, Sharma, Meenakshi, Singh, Shalini, Arora, Rashmi, Rasaily, Reeta, Anjana, Ranjit M, Mohan, Viswanathan, Agrawal, Anurag, Chopra, Arvind, Mathew, Ashish J, Bhardwaj, Deeksha, Muraleedharan, Pallavi, Mutreja, Parul, Bienhoff, Kelly, Glenn, Scott, Abdulkader, Rizwan S, Aggarwal, Ashutosh N, Aggarwal, Rakesh, Albert, Sandra, Ambekar, Atul, Arora, Monika, Bachani, Damodar, Bavdekar, Ashish, Beig, Gufran, Bhansali, Anil, Bhargava, Anurag, Bhatia, Eesh, Camara, Bilali, Christopher, D J, Das, Siddharth K, Dave, Paresh V, Dey, Sagnik, Ghoshal, Aloke G, Gopalakrishnan, N, Guleria, Randeep, Gupta, Rajeev, Gupta, Subodh S, Gupta, Tarun, Gupte, M D, Gururaj, G, Harikrishnan, Sivadasanpillai, Iyer, Veena, Jain, Sudhir K, Jeemon, Panniyamamkal, Joshua, Vasna, Kant, Rajni, Kar, Anita, Kataki, Amal C, Katoch, Kiran, Khanna, Tripti, Khera, Ajay, Kinra, Sanjay, Koul, Parvaiz A, Krishnan, Anand, Kumar, Avdhesh, Kumar, Raman K, Kumar, Rashmi, Kurpad, Anura, Ladusingh, Laishram, Lodha, Rakesh, Mahesh, P A, Malhotra, Rajesh, Mathai, Matthews, Mavalankar, Dileep, Mohan BV, Murali, Mukhopadhyay, Satinath, Murhekar, Manoj, Murthy, G V S, Nair, Sanjeev, Nair, Sreenivas A, Nanda, Lipika, Nongmaithem, Romi S, Oommen, Anu M, Pandian, Jeyaraj D, Pandya, Sapan, Parameswaran, Sreejith, Pati, Sanghamitra, Prasad, Kameshwar, Prasad, Narayan, Purwar, Manorama, Rahim, Asma, Raju, Sreebhushan, Ramji, Siddarth, Rangaswamy, Thara, Rath, Goura K, Roy, Ambuj, Sabde, Yogesh, Sachdeva, K S, Sadhu, Harsiddha, Sagar, Rajesh, Sankar, Mari J, Sharma, Rajendra, Shet, Anita, Shirude, Shreya, Shukla, Rajan, Shukla, Sharvari R, Singh, Gagandeep, Singh, Narinder P, Singh, Virendra, Sinha, Anju, Sinha, Dhirendra N, Srivastava, R K, Srividya, A, Suri, Vanita, Swaminathan, Rajaraman, Sylaja, P N, Tandale, Babasaheb, Thakur, J S, Thankappan, Kavumpurathu R, Thomas, Nihal, Tripathy, Srikanth, Varghese, Mathew, Varughese, Santosh, Venkatesh, S, Venugopal, K, Vijayakumar, Lakshmi, Xavier, Denis, Yajnik, Chittaranjan S, Zachariah, Geevar, Zodpey, Sanjay, Rao, J V R Prasada, Vos, Theo, Reddy, K Srinath, Murray, Christopher J L, and Swaminathan, Soumya

Published
2017
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49. Seroprevalence of IgG antibodies against SARS-CoV-2 among the general population and healthcare workers in India, June-July 2021: A population-based cross-sectional study

Author

Murhekar, Manoj V., Bhatnagar, Tarun, Thangaraj, Jeromie Wesley Vivian, Saravanakumar, V., Santhosh Kumar, Muthusamy, Selvaraju, Sriram, Rade, Kiran, Kumar, C. P. Girish, Sabarinathan, R., Asthana, Smita, Balachandar, Rakesh, Bangar, Sampada Dipak, Bansal, Avi Kumar, Bhat, Jyothi, Chakraborty, Debjit, Chopra, Vishal, Das, Dasarathi, Devi, Kangjam Rekha, Dwivedi, Gaurav Raj, Jain, Agam, Khan, S. Muhammad Salim, Kumar, M. Sunil, Laxmaiah, Avula, Madhukar, Major, Mahapatra, Amarendra, Ramesh, Talluri, Rangaraju, Chethana, Turuk, Jyotirmayee, Yadav, Suresh, and Bhargava, Balram

Subjects
Immunoglobulin G -- Statistics -- Health aspects, Medical personnel -- Statistics -- Health aspects, Biological sciences
Abstract

Background India began COVID-19 vaccination in January 2021, initially targeting healthcare and frontline workers. The vaccination strategy was expanded in a phased manner and currently covers all individuals aged 18 years and above. India experienced a severe second wave of COVID-19 during March-June 2021. We conducted a fourth nationwide serosurvey to estimate prevalence of SARS-CoV-2 antibodies in the general population aged [greater than or equal to]6 years and healthcare workers (HCWs). Methods and findings We did a cross-sectional study between 14 June and 6 July 2021 in the same 70 districts across 20 states and 1 union territory where 3 previous rounds of serosurveys were conducted. From each district, 10 clusters (villages in rural areas and wards in urban areas) were selected by the probability proportional to population size method. From each district, a minimum of 400 individuals aged [greater than or equal to]6 years from the general population (40 individuals from each cluster) and 100 HCWs from the district public health facilities were included. The serum samples were tested for the presence of IgG antibodies against S1-RBD and nucleocapsid protein of SARS-CoV-2 using chemiluminescence immunoassay. We estimated the weighted and test-adjusted seroprevalence of IgG antibodies against SARS-CoV-2, along with 95% CIs, based on the presence of antibodies to S1-RBD and/or nucleocapsid protein. Of the 28,975 individuals who participated in the survey, 2,892 (10%) were aged 6-9 years, 5,798 (20%) were aged 10-17 years, and 20,285 (70%) were aged [greater than or equal to]18 years; 15,160 (52.3%) participants were female, and 21,794 (75.2%) resided in rural areas. The weighted and test-adjusted prevalence of IgG antibodies against S1-RBD and/or nucleocapsid protein among the general population aged [greater than or equal to]6 years was 67.6% (95% CI 66.4% to 68.7%). Seroprevalence increased with age (p < 0.001) and was not different in rural and urban areas (p = 0.822). Compared to unvaccinated adults (62.3%, 95% CI 60.9% to 63.7%), seroprevalence was significantly higher among individuals who had received 1 vaccine dose (81.0%, 95% CI 79.6% to 82.3%, p < 0.001) and 2 vaccine doses (89.8%, 95% CI 88.4% to 91.1%, p < 0.001). The seroprevalence of IgG antibodies among 7,252 HCWs was 85.2% (95% CI 83.5% to 86.7%). Important limitations of the study include the survey design, which was aimed to estimate seroprevalence at the national level and not at a sub-national level, and the non-participation of 19% of eligible individuals in the survey. Conclusions Nearly two-thirds of individuals aged [greater than or equal to]6 years from the general population and 85% of HCWs had antibodies against SARS-CoV-2 by June-July 2021 in India. As one-third of the population is still seronegative, it is necessary to accelerate the coverage of COVID-19 vaccination among adults and continue adherence to non-pharmaceutical interventions., Author(s): Manoj V. Murhekar 1,*, Tarun Bhatnagar 1, Jeromie Wesley Vivian Thangaraj 1, V. Saravanakumar 1, Muthusamy Santhosh Kumar 1, Sriram Selvaraju 2, Kiran Rade 3, C. P. Girish Kumar [...]

Published
2021
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