1. The association of posttraumatic stress disorder, depression, and head injury with mid‐life cognitive function in civilian women
- Author
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Lawn, Rebecca B, Jha, Shaili C, Liu, Jiaxuan, Sampson, Laura, Murchland, Audrey R, Sumner, Jennifer A, Roberts, Andrea L, Disner, Seth G, Grodstein, Francine, Kang, Jae H, Kubzansky, Laura D, Chibnik, Lori B, and Koenen, Karestan C
- Subjects
Clinical and Health Psychology ,Psychology ,Depression ,Mind and Body ,Anxiety Disorders ,Behavioral and Social Science ,Neurosciences ,Post-Traumatic Stress Disorder (PTSD) ,Physical Injury - Accidents and Adverse Effects ,Clinical Research ,Mental Health ,Brain Disorders ,Aetiology ,2.3 Psychological ,social and economic factors ,Evaluation of treatments and therapeutic interventions ,6.6 Psychological and behavioural ,Mental health ,Good Health and Well Being ,Aged ,Cognition ,Craniocerebral Trauma ,Cross-Sectional Studies ,Female ,Humans ,Middle Aged ,Stress Disorders ,Post-Traumatic ,cognition ,cogstate ,depression ,head injury ,mild traumatic brain injury ,posttraumatic stress disorder ,women ,Clinical Sciences ,Psychiatry ,Clinical sciences ,Clinical and health psychology ,Social and personality psychology - Abstract
BackgroundDespite evidence linking posttraumatic stress disorder (PTSD), depression, and head injury, separately, with worse cognitive performance, investigations of their combined effects on cognition are limited in civilian women.MethodsThe Cogstate Brief Battery assessment was administered in 10,681 women from the Nurses' Health Study II cohort, mean age 64.9 years (SD = 4.6). Psychological trauma, PTSD, depression, and head injury were assessed using online questionnaires. In this cross-sectional analysis, we used linear regression models to estimate mean differences in cognition by PTSD/depression status and stratified by history of head injury.ResultsHistory of head injury was prevalent (36%), and significantly more prevalent among women with PTSD and depression (57% of women with PTSD and depression, 21% of women with no psychological trauma or depression). Compared to having no psychological trauma or depression, having combined PTSD and depression was associated with worse performance on psychomotor speed/attention ( β = -.15, p = .001) and learning/working memory ( β = -.15, p
- Published
- 2022