24 results on '"Muratori Roberto"'
Search Results
2. First-episode Psychosis and Migration in Italy : Results from a Study in the Italian Mental Health Services (Pep-Ita Study)
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Tarricone, Ilaria, D’Andrea, Giuseppe, Storbini, Viviana, Braca, Mauro, Ferrari, Silvia, Reggianini, Corinna, Rigatelli, Marco, Gramaglia, Carla, Zeppegno, Patrizia, Gambaro, Eleonora, Luciano, Mario, Ceregato, Alessio, Altamura, Mario, Barrasso, Giuseppe, Primavera, Diego, Carpiniello, Bernardo, Todarello, Orlando, Berlincioni, Vanna, Podavini, Francesca, Morgan, Craig, Murray, Robin M., Di Forti, Marta, Muratori, Roberto, and Berardi, Domenico
- Published
- 2021
3. The relationship of symptom dimensions with premorbid adjustment and cognitive characteristics at first episode psychosis: Findings from the EU-GEI study
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Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Sanchez-Gutierrez, Teresa, Tripoli, Giada, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Sideli, Lucia, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, Del-Ben, Cristina Marta, Gayer-Anderson, Charlotte, Jongsma, Hannah E., Kirkbride, James B., Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre-Michel, Menezes, Paulo Rossi, Rutten, Bart P., Santos, Jose Luis, Sanjuán, Julio, Selten, Jean-Paul, Szöke, Andrei, Tarricone, Ilaria, Muratori, Roberto, Tortelli, Andrea, Velthorst, Eva, Rodriguez, Victoria, Quattrone, Andrea, Jones, Peter B., Van Os, Jim, Vassos, Evangelos, Morgan, Craig, de Haan, Lieuwe, Reininghaus, Ulrich, Cardno, Alastair G., Di Forti, Marta, Murray, Robin M., and Quattrone, Diego
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- 2021
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4. Prevalence and effectiveness of psychiatric treatments for patients with IBD: A systematic literature review
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Tarricone, Ilaria, Regazzi, Maria Giulia, Bonucci, Giulia, Rizzello, Fernando, Carini, Giovanni, Muratori, Roberto, Poggioli, Gilberto, and Campieri, Massimo
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- 2017
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5. Psychological and attitudinal assessment of patients with Fibromyalgia undergoing antalgic management: a short report
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Balzani Eleonora, Fanelli Andrea, Tarricone Ilaria, Muratori Roberto, Campesato Manuela, Picone Carmela Tatiana, and Melotti Rita Maria
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General Medicine - Abstract
Objectives: Fibromyalgia (FM) is a widespread condition that is difficult to manage medically. Often algologists are faced with patients who are poorly compliant with pharmacological treatment or with concomitant mood problems. There are treatments tailored to temperament and character patterns. In this study using the division into pain persistence and pain avoidance patterns, a stratification was hypothesized to facilitate its medical management using self-administered questionnaires. Methods: We screened the population consisting of FM patients to four different questionnaires, namely the Temperament and Character Inventory (TCI), Hospital Anxiety and Depression Scale, Short form 36 and the INTERMED- Self Assessment. Results: A total of thirty-two patients were enrolled. The analyzed population showed preponderant pain avoidance characteristics (90.7%). The persistence pattern proved to be present in only 9.3% of the population. The FM patients examined also reported an incidence of anxiety disorder of 71.9% and depressive disorder of 75%. Conclusion: Dividing the population with FM into patterns yielded uniform results. This justifies a multidisciplinary approach in these FM patients. The high incidence of anxiety and depression from the test results is an outcome that suggests the adoption of the HADS tool in the antalgic evaluation of FM patients.
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- 2022
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6. Synergistic effects of childhood adversity and polygenic risk in first-episode psychosis: the EU-GEI study
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European Commission, South-Eastern Norway Regional Health Authority, Brain and Behavior Research Foundation, Aas, Monica [0000-0002-2338-5826], Aas, Monica, Alameda, Luis, Di Forti, Marta, Quattrone, Diego, Dazzan, Paola, Trotta, Antonella, Ferraro, Laura, Rodríguez, Victoria, Vassos, Evangelos, Sham, Pak C., Tripoli, Giada, La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Muratori, Roberto, Berardi, Domenico, Lasalvia, Antonio, Tosato, Sarah, Szöke, Andrei, Llorca, Pierre-Michel, Arango, Celso, Tortelli, Andrea, Haan, Lieuwe de, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, José Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B., Jongsma, Hannah E., Kirkbride, James B., Rutten, Bart P. F., Os, Jim van, Gayer-Anderson, Charlotte, Murray, Robin M., Morgan, Craig, European Commission, South-Eastern Norway Regional Health Authority, Brain and Behavior Research Foundation, Aas, Monica [0000-0002-2338-5826], Aas, Monica, Alameda, Luis, Di Forti, Marta, Quattrone, Diego, Dazzan, Paola, Trotta, Antonella, Ferraro, Laura, Rodríguez, Victoria, Vassos, Evangelos, Sham, Pak C., Tripoli, Giada, La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Muratori, Roberto, Berardi, Domenico, Lasalvia, Antonio, Tosato, Sarah, Szöke, Andrei, Llorca, Pierre-Michel, Arango, Celso, Tortelli, Andrea, Haan, Lieuwe de, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, José Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B., Jongsma, Hannah E., Kirkbride, James B., Rutten, Bart P. F., Os, Jim van, Gayer-Anderson, Charlotte, Murray, Robin M., and Morgan, Craig
- Abstract
[Background] A history of childhood adversity is associated with psychotic disorder, with an increase in risk according to the number of exposures. However, it is not known why only some exposed individuals go on to develop psychosis. One possibility is pre-existing polygenic vulnerability. Here, we investigated, in the largest sample of first-episode psychosis (FEP) cases to date, whether childhood adversity and high polygenic risk scores for schizophrenia (SZ-PRS) combine synergistically to increase the risk of psychosis, over and above the effect of each alone., [Methods] We assigned a schizophrenia-polygenic risk score (SZ-PRS), calculated from the Psychiatric Genomics Consortium (PGC2), to all participants in a sample of 384 FEP patients and 690 controls from the case–control component of the EU-GEI study. Only participants of European ancestry were included in the study. A history of childhood adversity was collected using the Childhood Trauma Questionnaire (CTQ). Synergistic effects were estimated using the interaction contrast ratio (ICR) [odds ratio (OR)exposure and PRS − ORexposure − ORPRS + 1] with adjustment for potential confounders., [Results] There was some evidence that the combined effect of childhood adversities and polygenic risk was greater than the sum of each alone, as indicated by an ICR greater than zero [i.e. ICR 1.28, 95% confidence interval (CI) −1.29 to 3.85]. Examining subtypes of childhood adversities, the strongest synergetic effect was observed for physical abuse (ICR 6.25, 95% CI −6.25 to 20.88)., [Conclusions] Our findings suggest possible synergistic effects of genetic liability and childhood adversity experiences in the onset of FEP, but larger samples are needed to increase precision of estimates.
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- 2023
7. Child maltreatment, migration and risk of first-episode psychosis: results from the multinational EU-GEI study
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Hersenen-Medisch 1, Brain, D'Andrea, Giuseppe, Lal, Jatin, Tosato, Sarah, Gayer-Anderson, Charlotte, Jongsma, Hannah E, Stilo, Simona A, van der Ven, Els, Quattrone, Diego, Velthorst, Eva, Berardi, Domenico, Rossi Menezes, Paulo, Arango, Celso, Parellada, Mara, Lasalvia, Antonio, La Cascia, Caterina, Ferraro, Laura, La Barbera, Daniele, Sideli, Lucia, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, Jose Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Tripoli, Giada, Llorca, Pierre-Michel, de Haan, Lieuwe, Selten, Jean-Paul, Tortelli, Andrea, Szöke, Andrei, Muratori, Roberto, Rutten, Bart P, van Os, Jim, Jones, Peter B, Kirkbride, James B, Murray, Robin M, di Forti, Marta, Tarricone, Ilaria, Morgan, Craig, Hersenen-Medisch 1, Brain, D'Andrea, Giuseppe, Lal, Jatin, Tosato, Sarah, Gayer-Anderson, Charlotte, Jongsma, Hannah E, Stilo, Simona A, van der Ven, Els, Quattrone, Diego, Velthorst, Eva, Berardi, Domenico, Rossi Menezes, Paulo, Arango, Celso, Parellada, Mara, Lasalvia, Antonio, La Cascia, Caterina, Ferraro, Laura, La Barbera, Daniele, Sideli, Lucia, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, Jose Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Tripoli, Giada, Llorca, Pierre-Michel, de Haan, Lieuwe, Selten, Jean-Paul, Tortelli, Andrea, Szöke, Andrei, Muratori, Roberto, Rutten, Bart P, van Os, Jim, Jones, Peter B, Kirkbride, James B, Murray, Robin M, di Forti, Marta, Tarricone, Ilaria, and Morgan, Craig
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- 2023
8. Synergistic effects of childhood adversity and polygenic risk in first-episode psychosis: The EU-GEI study
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Hersenen-Medisch 1, Brain, Aas, Monica, Alameda, Luis, Di Forti, Marta, Quattrone, Diego, Dazzan, Paola, Trotta, Antonella, Ferraro, Laura, Rodriguez, Victoria, Vassos, Evangelos, Sham, Pak, Tripoli, Giada, Cascia, Caterina La, Barbera, Daniele La, Tarricone, Ilaria, Muratori, Roberto, Berardi, Domenico, Lasalvia, Antonio, Tosato, Sarah, Szöke, Andrei, Llorca, Pierre Michel, Arango, Celso, Tortelli, Andrea, De Haan, Lieuwe, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, Jose Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean Paul, Jones, Peter B., Jongsma, Hannah E., Kirkbride, James B., Rutten, Bart P.F., Van Os, Jim, Gayer-Anderson, Charlotte, Murray, Robin M., Morgan, Craig, Hersenen-Medisch 1, Brain, Aas, Monica, Alameda, Luis, Di Forti, Marta, Quattrone, Diego, Dazzan, Paola, Trotta, Antonella, Ferraro, Laura, Rodriguez, Victoria, Vassos, Evangelos, Sham, Pak, Tripoli, Giada, Cascia, Caterina La, Barbera, Daniele La, Tarricone, Ilaria, Muratori, Roberto, Berardi, Domenico, Lasalvia, Antonio, Tosato, Sarah, Szöke, Andrei, Llorca, Pierre Michel, Arango, Celso, Tortelli, Andrea, De Haan, Lieuwe, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, Jose Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean Paul, Jones, Peter B., Jongsma, Hannah E., Kirkbride, James B., Rutten, Bart P.F., Van Os, Jim, Gayer-Anderson, Charlotte, Murray, Robin M., and Morgan, Craig
- Published
- 2023
9. Child maltreatment, migration and risk of first-episode psychosis: results from the multinational EU-GEI study
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D'Andrea, Giuseppe, primary, Lal, Jatin, additional, Tosato, Sarah, additional, Gayer-Anderson, Charlotte, additional, Jongsma, Hannah E., additional, Stilo, Simona A., additional, van der Ven, Els, additional, Quattrone, Diego, additional, Velthorst, Eva, additional, Berardi, Domenico, additional, Rossi Menezes, Paulo, additional, Arango, Celso, additional, Parellada, Mara, additional, Lasalvia, Antonio, additional, La Cascia, Caterina, additional, Ferraro, Laura, additional, La Barbera, Daniele, additional, Sideli, Lucia, additional, Bobes, Julio, additional, Bernardo, Miguel, additional, Sanjuán, Julio, additional, Santos, Jose Luis, additional, Arrojo, Manuel, additional, Del-Ben, Cristina Marta, additional, Tripoli, Giada, additional, Llorca, Pierre-Michel, additional, de Haan, Lieuwe, additional, Selten, Jean-Paul, additional, Tortelli, Andrea, additional, Szöke, Andrei, additional, Muratori, Roberto, additional, Rutten, Bart P., additional, van Os, Jim, additional, Jones, Peter B., additional, Kirkbride, James B., additional, Murray, Robin M., additional, di Forti, Marta, additional, Tarricone, Ilaria, additional, and Morgan, Craig, additional
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- 2022
- Full Text
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10. Migration history and risk of psychosis: results from the multinational EU-GEI study
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Hersenen-Medisch 1, Brain, Tarricone, Ilaria, D'Andrea, Giuseppe, Jongsma, Hannah E, Tosato, Sarah, Gayer-Anderson, Charlotte, Stilo, Simona A, Suprani, Federico, Iyegbe, Conrad, van der Ven, Els, Quattrone, Diego, di Forti, Marta, Velthorst, Eva, Rossi Menezes, Paulo, Arango, Celso, Parellada, Mara, Lasalvia, Antonio, La Cascia, Caterina, Ferraro, Laura, Bobes, Julio, Bernardo, Miguel, Sanjuán, Iulio, Santos, Jose Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Tripoli, Giada, Llorca, Pierre-Michel, de Haan, Lieuwe, Selten, Jean-Paul, Tortelli, Andrea, Szöke, Andrei, Muratori, Roberto, Rutten, Bart P, van Os, Jim, Jones, Peter B, Kirkbride, James B, Berardi, Domenico, Murray, Robin M, Morgan, Craig, Hersenen-Medisch 1, Brain, Tarricone, Ilaria, D'Andrea, Giuseppe, Jongsma, Hannah E, Tosato, Sarah, Gayer-Anderson, Charlotte, Stilo, Simona A, Suprani, Federico, Iyegbe, Conrad, van der Ven, Els, Quattrone, Diego, di Forti, Marta, Velthorst, Eva, Rossi Menezes, Paulo, Arango, Celso, Parellada, Mara, Lasalvia, Antonio, La Cascia, Caterina, Ferraro, Laura, Bobes, Julio, Bernardo, Miguel, Sanjuán, Iulio, Santos, Jose Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Tripoli, Giada, Llorca, Pierre-Michel, de Haan, Lieuwe, Selten, Jean-Paul, Tortelli, Andrea, Szöke, Andrei, Muratori, Roberto, Rutten, Bart P, van Os, Jim, Jones, Peter B, Kirkbride, James B, Berardi, Domenico, Murray, Robin M, and Morgan, Craig
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- 2022
11. Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia
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Pardiñas, Antonio F., Smart, Sophie E., Corvin, Aiden, Freimer, Nelson B., Friedl, Marion, Friedman, Joseph I., Fromer, Menachem, Genovese, Giulio, Georgieva, Lyudmila, Gershon, Elliot S., Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Fanous, Ayman H., Goldstein, Jacqueline I., Golimbet, Vera, Gopal, Srihari, Gratten, Jacob, Haan, Lieuwe de, Hammer, Christian, Hamshere, Marian L., Hansen, Mark, Hansen, Thomas, Haroutunian, Vahram, Frank, Josef, Hartmann, Annette M., Henskens, Frans A., Herms, Stefan, Hirschhorn, Joel N., Hoffmann, Per, Hofman, Andrea, Hollegaard, Mads V., Hougaard, David M., Ikeda, Masashi, Joa, Inge, Kelly, Brian, Julià, Antonio, Kahn, René S., Kalaydjieva, Luba, Karachanak-Yankova, Sena, Karjalainen, Juha, Kavanagh, David, Keller, Matthew C., Kennedy, James L., Khrunin, Andrey, Kim, Yunjung, McQuillin, Andrew, Klovins, Janis, Knowles, James A., Konte, Bettina, Kucinskas, Vaidutis, Kucinskiene, Zita Ausrele, Kuzelova-Ptackova, Hana, Kähler, Anna K., Laurent, Claudine, Keong, Jimmy Lee Chee, Lee, S. Hong, Melle, Ingrid, Lerer, Bernard, Li, Miaoxin, Li, Tao, Liang, Kung-Yee, Lieberman, Jeffrey, Limborska, Svetlana, Loughland, Carmel M., Lubinski, Jan, Lönnqvist, Jouko, Macek, Milan, Mortensen, Preben B., Magnusson, Patrik K. E., Maher, Brion S., Maier, Wolfgang, Mallet, Jacques, Marsal, Sara, Mattheisen, Manuel, Mattingsdal, Morten, McCarley, Robert W., McDonald, Colm, McIntosh, Andrew M., Mowry, Bryan J., Meier, Sandra, Meijer, Carin J., Melegh, Bela, Mesholam-Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihra, Mokrab, Younes, Pato, Carlos N., Morris, Derek W., Mors, Ole, Murphy, Kieran C., Myin-Germeys, Inez, Müller-Myhsok, Bertram, Nelis, Mari, Nenadic, Igor, Nertney, Deborah A., Nestadt, Gerald, Nicodemus, Kristin K., Periyasamy, Sathish, Nikitina-Zake, Liene, Nisenbaum, Laura, Nordin, Annelie, O’Callaghan, Eadbhard, O’Dushlaine, Colm, O’Neill, F. Anthony, Oh, Sang-Yun, Olincy, Ann, Olsen, Line, Os, Jim Van, Willcocks, Isabella R., Rietschel, Marcella, Pantelis, Christos, Papadimitriou, George N., Papiol, Sergi, Parkhomenko, Elena, Pato, Michele T., Paunio, Tiina, Pejovic-Milovancevic, Milica, Perkins, Diana O., Pietiläinen, Olli, Pimm, Jonathan, Rujescu, Dan, Pocklington, Andrew J., Powell, John, Price, Alkes, Pulver, Ann E., Purcell, Shaun M., Quested, Digby, Rasmussen, Henrik B., Reichenberg, Abraham, Reimers, Mark A., Richards, Alexander L., Simonsen, Carmen, Roffman, Joshua L., Roussos, Panos, Ruderfer, Douglas M., Salomaa, Veikko, Sanders, Alan R., Schall, Ulrich, Schubert, Christian R., Schulze, Thomas G., Schwab, Sibylle G., Scolnick, Edward M., St Clair, David, Scott, Rodney J., Seidman, Larry J., Shi, Jianxin, Sigurdsson, Engilbert, Silagadze, Teimuraz, Silverman, Jeremy M., Sim, Kang, Slominsky, Petr, Smoller, Jordan W., So, Hon-Cheong, Tooney, Paul, Spencer, Chris C. A., Stahl, Eli A., Stefansson, Hreinn, Steinberg, Stacy, Stogmann, Elisabeth, Straub, Richard E., Strengman, Eric, Strohmaier, Jana, Stroup, T. Scott, Subramaniam, Mythily, Wu, Jing Qin, Suvisaari, Jaana, Svrakic, Dragan M., Szatkiewicz, Jin P., Söderman, Erik, Thirumalai, Srinivas, Toncheva, Draga, Tosato, Sarah, Veijola, Juha, Waddington, John, Walsh, Dermot, Andreassen, Ole A., Wang, Dai, Wang, Qiang, Webb, Bradley T., Weiser, Mark, Wildenauer, Dieter B., Williams, Nigel M., Williams, Stephanie, Witt, Stephanie H., Wolen, Aaron R., Wong, Emily H. M., Kowalec, Kaarina, Wormley, Brandon K., Xi, Hualin Simon, Zai, Clement C., Zheng, Xuebin, Zimprich, Fritz, Wray, Naomi R., Stefansson, Kari, Visscher, Peter M., Adolfsson, Rolf, Blackwood, Douglas H. R., Sullivan, Patrick F., Bramon, Elvira, Buxbaum, Joseph D., Børglum, Anders D., Cichon, Sven, Darvasi, Ariel, Domenici, Enrico, Ehrenreich, Hannelore, Esko, Tõnu, Gejman, Pablo V., Gill, Michael, Murray, Robin M., Gurling, Hugh, Hultman, Christina M., Iwata, Nakao, Jablensky, Assen V., Jönsson, Erik G., Kendler, Kenneth S., Kirov, George, Knight, Jo, Lencz, Todd, Levinson, Douglas F., Holmans, Peter A., Owen, Michael J., Li, Qingqin S., Liu, Jianjun, Malhotra, Anil K., McCarroll, Steven A., Moran, Jennifer L., Nöthen, Markus M., Ophoff, Roel A., Palotie, Aarno, Petryshen, Tracey L., MacCabe, James H., Posthuma, Danielle, Riley, Brien P., Sham, Pak C., Sklar, Pamela, Clair, David St, Weinberger, Daniel R., Wendland, Jens R., Werge, Thomas, Daly, Mark J., Agbedjro, Deborah, O’Donovan, Michael C., Stahl, Daniel, Kapur, Shitij, Millgate, Edward, Kepinska, Adrianna, Kravariti, Eugenia, Ajnakina, Olesya, Alameda, Luis, Barnes, Thomas R. E., Berardi, Domenico, Bonora, Elena, Walters, James T. R., Camporesi, Sara, Cleusix, Martine, Conus, Philippe, Crespo-Facorro, Benedicto, D’Andrea, Giuseppe, Demjaha, Arsime, Do, Kim Q., Doody, Gillian A., Eap, Chin B., Ferchiou, Aziz, Ripke, Stephan, Di Forti, Marta, Guidi, Lorenzo, Homman, Lina, Jenni, Raoul, Joyce, Eileen M., Kassoumeri, Laura, Khadimallah, Inès, Lastrina, Ornella, Muratori, Roberto, Noyan, Handan, Neale, Benjamin M., O’Neill, Francis A., Pignon, Baptiste, Restellini, Romeo, Richard, Jean-Romain, Schürhoff, Franck, Španiel, Filip, Szöke, Andrei, Tarricone, Ilaria, Tortelli, Andrea, Üçok, Alp, Farh, Kai-How, Vázquez-Bourgon, Javier, Lee, Phil, Bulik-Sullivan, Brendan, Collier, David A., Dennison, Charlotte A., Huang, Hailiang, Pers, Tune H., Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Begemann, Martin, Belliveau, Richard A ., Lynham, Amy J., Bene, Judit, Bergen, Sarah E., Bevilacqua, Elizabeth, Black, Donald W., Bruggeman, Richard, Buccola, Nancy G., Buckner, Randy L., Byerley, William, Cahn, Wiepke, Cai, Guiqing, Legge, Sophie E., Campion, Dominique, Cantor, Rita M., Carr, Vaughan J., Carrera, Noa, Catts, Stanley V., Chambert, Kimberly D., Chan, Raymond C. K., Chen, Ronald Y. L., Chen, Eric Y. H., Cheng, Wei, Baune, Bernhard T., Cheung, Eric F. C., Chong, Siow Ann, Cloninger, C. Robert, Cohen, David, Cohen, Nadine, Cormican, Paul, Craddock, Nick, Crowley, James J., Curtis, David, Davidson, Michael, Bigdeli, Tim B., Davis, Kenneth L., Degenhardt, Franziska, Favero, Jurgen Del, DeLisi, Lynn E., Demontis, Ditte, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Donohoe, Gary, Drapeau, Elodie, Cairns, Murray J., Duan, Jubao, Dudbridge, Frank, Durmishi, Naser, Eichhammer, Peter, Eriksson, Johan, Escott-Price, Valentina, Essioux, Laurent, Farrell, Martilias S., Franke, Lude, Freedman, Robert, Genetics Workstream of the Schizophrenia Treatment Resistance and Therapeutic Advances (STRATA) Consortium and the Schizophrenia Working Group of the Psychiatric Genomics Consortium (PGC), Ripke, S., Neale, B.M., Farh, K.H., Lee, P., Bulik-Sullivan, B., Collier, D.A., Huang, H., Pers, T.H., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F., Bacanu, S.A., Begemann, M., Belliveau, R.A., Bene, J., Bergen, S.E., Bevilacqua, E., Black, D.W., Bruggeman, R., Buccola, N.G., Buckner, R.L., Byerley, W., Cahn, W., Cai, G., Campion, D., Cantor, R.M., Carr, V.J., Carrera, N., Catts, S.V., Chambert, K.D., Chan, RCK, Chen, RYL, Chen, EYH, Cheng, W., Cheung, EFC, Chong, S.A., Cloninger, C.R., Cohen, D., Cohen, N., Cormican, P., Craddock, N., Crowley, J.J., Curtis, D., Davidson, M., Davis, K.L., Degenhardt, F., Favero, J.D., DeLisi, L.E., Demontis, D., Dikeos, D., Dinan, T., Djurovic, S., Donohoe, G., Drapeau, E., Duan, J., Dudbridge, F., Durmishi, N., Eichhammer, P., Eriksson, J., Escott-Price, V., Essioux, L., Farrell, M.S., Franke, L., Freedman, R., Freimer, N.B., Friedl, M., Friedman, J.I., Fromer, M., Genovese, G., Georgieva, L., Gershon, E.S., Giegling, I., Giusti-Rodríguez, P., Godard, S., Goldstein, J.I., Golimbet, V., Gopal, S., Gratten, J., Haan, L., Hammer, C., Hamshere, M.L., Hansen, M., Hansen, T., Haroutunian, V., Hartmann, A.M., Henskens, F.A., Herms, S., Hirschhorn, J.N., Hoffmann, P., Hofman, A., Hollegaard, M.V., Hougaard, D.M., Ikeda, M., Joa, I., Julià, A., Kahn, R.S., Kalaydjieva, L., Karachanak-Yankova, S., Karjalainen, J., Kavanagh, D., Keller, M.C., Kennedy, J.L., Khrunin, A., Kim, Y., Klovins, J., Knowles, J.A., Konte, B., Kucinskas, V., Kucinskiene, Z.A., Kuzelova-Ptackova, H., Kähler, A.K., Laurent, C., Keong, JLC, Lee, S.H., Lerer, B., Li, M., Li, T., Liang, K.Y., Lieberman, J., Limborska, S., Loughland, C.M., Lubinski, J., Lönnqvist, J., Macek, M., Magnusson, PKE, Maher, B.S., Maier, W., Mallet, J., Marsal, S., Mattheisen, M., Mattingsdal, M., McCarley, R.W., McDonald, C., McIntosh, A.M., Meier, S., Meijer, C.J., Melegh, B., Melle, I., Mesholam-Gately, R.I., Metspalu, A., Michie, P.T., Milani, L., Milanova, V., Mokrab, Y., Morris, D.W., Mors, O., Murphy, K.C., Myin-Germeys, I., Müller-Myhsok, B., Nelis, M., Nenadic, I., Nertney, D.A., Nestadt, G., Nicodemus, K.K., Nikitina-Zake, L., Nisenbaum, L., Nordin, A., O'Callaghan, E., O'Dushlaine, C., O'Neill, F.A., Oh, S.Y., Olincy, A., Olsen, L., Os, J.V., Pantelis, C., Papadimitriou, G.N., Papiol, S., Parkhomenko, E., Pato, M.T., Paunio, T., Pejovic-Milovancevic, M., Perkins, D.O., Pietiläinen, O., Pimm, J., Pocklington, A.J., Powell, J., Price, A., Pulver, A.E., Purcell, S.M., Quested, D., Rasmussen, H.B., Reichenberg, A., Reimers, M.A., Richards, A.L., Roffman, J.L., Roussos, P., Ruderfer, D.M., Salomaa, V., Sanders, A.R., Schall, U., Schubert, C.R., Schulze, T.G., Schwab, S.G., Scolnick, E.M., Scott, R.J., Seidman, L.J., Shi, J., Sigurdsson, E., Silagadze, T., Silverman, J.M., Sim, K., Slominsky, P., Smoller, J.W., So, H.C., Spencer, CCA, Stahl, E.A., Stefansson, H., Steinberg, S., Stogmann, E., Straub, R.E., Strengman, E., Strohmaier, J., Stroup, T.S., Subramaniam, M., Suvisaari, J., Svrakic, D.M., Szatkiewicz, J.P., Söderman, E., Thirumalai, S., Toncheva, D., Tosato, S., Veijola, J., Waddington, J., Walsh, D., Wang, D., Wang, Q., Webb, B.T., Weiser, M., Wildenauer, D.B., Williams, N.M., Williams, S., Witt, S.H., Wolen, A.R., Wong, EHM, Wormley, B.K., Xi, H.S., Zai, C.C., Zheng, X., Zimprich, F., Wray, N.R., Stefansson, K., Visscher, P.M., Adolfsson, R., Blackwood, DHR, Bramon, E., Buxbaum, J.D., Børglum, A.D., Cichon, S., Darvasi, A., Domenici, E., Ehrenreich, H., Esko, T., Gejman, P.V., Gill, M., Gurling, H., Hultman, C.M., Iwata, N., Jablensky, A.V., Jönsson, E.G., Kendler, K.S., Kirov, G., Knight, J., Lencz, T., Levinson, D.F., Li, Q.S., Liu, J., Malhotra, A.K., McCarroll, S.A., Moran, J.L., Mortensen, P.B., Nöthen, M.M., Ophoff, R.A., Palotie, A., Petryshen, T.L., Posthuma, D., Riley, B.P., Sham, P.C., Sklar, P., Clair, D.S., Weinberger, D.R., Wendland, J.R., Werge, T., Daly, M.J., Agbedjro, D., Stahl, D., Kapur, S., Millgate, E., Kepinska, A., Kravariti, E., Medical Research Council (UK), Cardiff University, Welsh Government, Health and Care Research Wales, European Commission, Academy of Medical Sciences (UK), Research Council of Norway, K. G. Jebsen Centres for Medical Research, National Institute for Health Research (UK), University College London, Government of Canada, University of Manitoba, Swedish Research Council, National Institute of Mental Health (US), Kings College London, Public Health Agency (Northern Ireland), The Psychiatry Research Trust, Maudsley Charity, Swiss National Science Foundation, Fondation Alamaya, Ministry of Health of the Czech Republic, Instituto de Salud Carlos III, Plan Nacional sobre Drogas (España), Fundació Seny, Fundación Marques de Valdecilla, Ministerio de Economía y Competitividad (España), Wellcome Trust, and Universidad de Cantabria
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Male ,endocrine system ,Multifactorial Inheritance ,animal structures ,Psychiatry and Behavioral Health ,Online First ,Humans ,Genetic Predisposition to Disease ,ddc:610 ,Neurogenetics ,Medicinsk genetik ,Original Investigation ,Research ,Schizophrenia Sprectum and Other Psychotic Disorders ,Featured ,Genetics and genomics ,Psychiatry and Mental health ,Neurology ,Psychotic Disorders ,Schizophrenia ,Female ,Medical Genetics ,hormones, hormone substitutes, and hormone antagonists ,Comments ,Genome-Wide Association Study - Abstract
[Importance] About 20% to 30% of people with schizophrenia have psychotic symptoms that do not respond adequately to first-line antipsychotic treatment. This clinical presentation, chronic and highly disabling, is known as treatment-resistant schizophrenia (TRS). The causes of treatment resistance and their relationships with causes underlying schizophrenia are largely unknown. Adequately powered genetic studies of TRS are scarce because of the difficulty in collecting data from well-characterized TRS cohorts., [Objective] To examine the genetic architecture of TRS through the reassessment of genetic data from schizophrenia studies and its validation in carefully ascertained clinical samples., [Design, Setting, and Participants] Two case-control genome-wide association studies (GWASs) of schizophrenia were performed in which the case samples were defined as individuals with TRS (n = 10 501) and individuals with non-TRS (n = 20 325). The differences in effect sizes for allelic associations were then determined between both studies, the reasoning being such differences reflect treatment resistance instead of schizophrenia. Genotype data were retrieved from the CLOZUK and Psychiatric Genomics Consortium (PGC) schizophrenia studies. The output was validated using polygenic risk score (PRS) profiling of 2 independent schizophrenia cohorts with TRS and non-TRS: a prevalence sample with 817 individuals (Cardiff Cognition in Schizophrenia [CardiffCOGS]) and an incidence sample with 563 individuals (Genetics Workstream of the Schizophrenia Treatment Resistance and Therapeutic Advances [STRATA-G])., [Main Outcomes and Measures] GWAS of treatment resistance in schizophrenia. The results of the GWAS were compared with complex polygenic traits through a genetic correlation approach and were used for PRS analysis on the independent validation cohorts using the same TRS definition., [Results] The study included a total of 85 490 participants (48 635 [56.9%] male) in its GWAS stage and 1380 participants (859 [62.2%] male) in its PRS validation stage. Treatment resistance in schizophrenia emerged as a polygenic trait with detectable heritability (1% to 4%), and several traits related to intelligence and cognition were found to be genetically correlated with it (genetic correlation, 0.41-0.69). PRS analysis in the CardiffCOGS prevalence sample showed a positive association between TRS and a history of taking clozapine (r2 = 2.03%; P = .001), which was replicated in the STRATA-G incidence sample (r2 = 1.09%; P = .04)., [Conclusions and Relevance] In this GWAS, common genetic variants were differentially associated with TRS, and these associations may have been obscured through the amalgamation of large GWAS samples in previous studies of broadly defined schizophrenia. Findings of this study suggest the validity of meta-analytic approaches for studies on patient outcomes, including treatment resistance., This work was supported by Medical Research Council Centre grant MR/L010305/1, Medical Research Council Program grant MR/P005748/1, and Medical Research Council Project grants MR/L011794/1 and MC_PC_17212 to Cardiff University and by the National Centre for Mental Health, funded by the Welsh Government through Health and Care Research Wales. This work acknowledges the support of the Supercomputing Wales project, which is partially funded by the European Regional Development Fund via the Welsh Government. Dr Pardiñas was supported by an Academy of Medical Sciences Springboard Award (SBF005\1083). Dr Andreassen was supported by the Research Council of Norway (grants 283798, 262656, 248980, 273291, 248828, 248778, and 223273); KG Jebsen Stiftelsen, South-East Norway Health Authority, and the European Union’s Horizon 2020 Research and Innovation Programme (grant 847776). Dr Ajnakina was supported by an National Institute for Health Research postdoctoral fellowship (PDF-2018-11-ST2-020). Dr Joyce was supported by the University College London Hospitals/UCL University College London Biomedical Research Centre. Dr Kowalec received funding from the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie grant agreement (793530) from the government of Canada Banting postdoctoral fellowship programme and the University of Manitoba. Dr Sullivan was supported by the Swedish Research Council (Vetenskapsrådet, D0886501), the European Union’s Horizon 2020 programme (COSYN, 610307) and the US National Institute of Mental Health (U01 MH109528 and R01 MH077139). The Psychiatric Genomics Consortium was partly supported by the National Institute Of Mental Health (grants R01MH124873). The Sweden Schizophrenia Study was supported by the National Institute Of Mental Health (grant R01MH077139). The STRATA consortium was supported by a Stratified Medicine Programme grant to Dr MacCabe from the Medical Research Council (grant MR/L011794/1), which funded the research and supported Drs Pardiñas, Smart, Kassoumeri, Murray, Walters, and MacCabe. Dr Smart was supported by a Collaboration for Leadership in Applied Health Research and Care South London at King’s College Hospital National Health Service Foundation Trust. The AESOP (US) cohort was funded by the UK Medical Research Council (grant G0500817). The Belfast (UK) cohort was funded by the Research and Development Office of Northern Ireland. The Bologna (Italy) cohort was funded by the European Community’s Seventh Framework program (HEALTH-F2-2010–241909, project EU-GEI). The Genetics and Psychosis project (London, UK) cohort was funded by the UK National Institute of Health Research Specialist Biomedical Research Centre for Mental Health, South London and the Maudsley National Health Service Mental Health Foundation Trust (SLAM) and the Institute of Psychiatry, Psychology, and Neuroscience at King’s College London; Psychiatry Research Trust; Maudsley Charity Research Fund; and the European Community’s Seventh Framework program (HEALTH-F2-2009-241909, project EU-GEI). The Lausanne (Switzerland) cohort was funded by the Swiss National Science Foundation (grants 320030_135736/1, 320030-120686, 324730-144064, 320030-173211, and 171804); the National Center of Competence in Research Synaptic Bases of Mental Diseases from the Swiss National Science Foundation (grant 51AU40_125759); and Fondation Alamaya. The Oslo (Norway) cohort was funded by the Research Council of Norway (grant 223273/F50, under the Centers of Excellence funding scheme, 300309, 283798) and the South-Eastern Norway Regional Health Authority (grants 2006233, 2006258, 2011085, 2014102, 2015088, and 2017-112). The Paris (France) cohort was funded by European Community’s Seventh Framework program (HEALTH-F2-2010–241909, project EU-GEI). The Prague (Czech Republic) cohort was funded by the Ministry of Health of the Czech Republic (grant NU20-04-00393). The Santander (Spain) cohort was funded by the following grants to Dr Crespo-Facorro: Instituto de Salud Carlos III (grants FIS00/3095, PI020499, PI050427, and PI060507), Plan Nacional de Drogas Research (grant 2005-Orden sco/3246/2004), SENY Fundatio Research (grant 2005-0308007), Fundacion Marques de Valdecilla (grant A/02/07, API07/011) and Ministry of Economy and Competitiveness and the European Fund for Regional Development (grants SAF2016-76046-R and SAF2013-46292-R). The West London (UK) cohort was funded by The Wellcome Trust (grants 042025, 052247, and 064607).
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- 2022
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12. Synergistic effects of childhood adversity and polygenic risk in first-episode psychosis: the EU-GEI study.
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Aas, Monica, Alameda, Luis, Di Forti, Marta, Quattrone, Diego, Dazzan, Paola, Trotta, Antonella, Ferraro, Laura, Rodriguez, Victoria, Vassos, Evangelos, Sham, Pak, Tripoli, Giada, Cascia, Caterina La, Barbera, Daniele La, Tarricone, Ilaria, Muratori, Roberto, Berardi, Domenico, Lasalvia, Antonio, Tosato, Sarah, Szöke, Andrei, and Llorca, Pierre-Michel
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SCHIZOPHRENIA risk factors ,CONFIDENCE intervals ,PSYCHOSES ,CASE-control method ,RISK assessment ,RESEARCH funding ,QUESTIONNAIRES ,DESCRIPTIVE statistics ,ODDS ratio ,CHILDREN - Abstract
Background: A history of childhood adversity is associated with psychotic disorder, with an increase in risk according to the number of exposures. However, it is not known why only some exposed individuals go on to develop psychosis. One possibility is pre-existing polygenic vulnerability. Here, we investigated, in the largest sample of first-episode psychosis (FEP) cases to date, whether childhood adversity and high polygenic risk scores for schizophrenia (SZ-PRS) combine synergistically to increase the risk of psychosis, over and above the effect of each alone. Methods: We assigned a schizophrenia-polygenic risk score (SZ-PRS), calculated from the Psychiatric Genomics Consortium (PGC2), to all participants in a sample of 384 FEP patients and 690 controls from the case–control component of the EU-GEI study. Only participants of European ancestry were included in the study. A history of childhood adversity was collected using the Childhood Trauma Questionnaire (CTQ). Synergistic effects were estimated using the interaction contrast ratio (ICR) [odds ratio (OR)
exposure and PRS − ORexposure − ORPRS + 1] with adjustment for potential confounders. Results: There was some evidence that the combined effect of childhood adversities and polygenic risk was greater than the sum of each alone, as indicated by an ICR greater than zero [i.e. ICR 1.28, 95% confidence interval (CI) −1.29 to 3.85]. Examining subtypes of childhood adversities, the strongest synergetic effect was observed for physical abuse (ICR 6.25, 95% CI −6.25 to 20.88). Conclusions: Our findings suggest possible synergistic effects of genetic liability and childhood adversity experiences in the onset of FEP, but larger samples are needed to increase precision of estimates. [ABSTRACT FROM AUTHOR]- Published
- 2023
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13. Synergistic effects of childhood adversity and polygenic risk in first-episode psychosis: the EU-GEI study
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Aas, Monica, primary, Alameda, Luis, additional, Di Forti, Marta, additional, Quattrone, Diego, additional, Dazzan, Paola, additional, Trotta, Antonella, additional, Ferraro, Laura, additional, Rodriguez, Victoria, additional, Vassos, Evangelos, additional, Sham, Pak, additional, Tripoli, Giada, additional, Cascia, Caterina La, additional, Barbera, Daniele La, additional, Tarricone, Ilaria, additional, Muratori, Roberto, additional, Berardi, Domenico, additional, Lasalvia, Antonio, additional, Tosato, Sarah, additional, Szöke, Andrei, additional, Llorca, Pierre-Michel, additional, Arango, Celso, additional, Tortelli, Andrea, additional, de Haan, Lieuwe, additional, Velthorst, Eva, additional, Bobes, Julio, additional, Bernardo, Miguel, additional, Sanjuán, Julio, additional, Santos, Jose Luis, additional, Arrojo, Manuel, additional, Del-Ben, Cristina Marta, additional, Menezes, Paulo Rossi, additional, Selten, Jean-Paul, additional, Jones, Peter B., additional, Jongsma, Hannah E., additional, Kirkbride, James B., additional, Rutten, Bart P. F., additional, van Os, Jim, additional, Gayer-Anderson, Charlotte, additional, Murray, Robin M., additional, and Morgan, Craig, additional
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- 2021
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14. The relationship of symptom dimensions with premorbid adjustment and cognitive characteristics at first episode psychosis: Findings from the EU-GEI study
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Hersenen-Medisch 1, Brain, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Sanchez-Gutierrez, Teresa, Tripoli, Giada, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Sideli, Lucia, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, Del-Ben, Cristina Marta, Gayer-Anderson, Charlotte, Jongsma, Hannah E., Kirkbride, James B., Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre Michel, Menezes, Paulo Rossi, Rutten, Bart P., Santos, Jose Luis, Sanjuán, Julio, Selten, Jean Paul, Szöke, Andrei, Tarricone, Ilaria, Muratori, Roberto, Tortelli, Andrea, Velthorst, Eva, Rodriguez, Victoria, Quattrone, Andrea, Jones, Peter B., Van Os, Jim, Vassos, Evangelos, Morgan, Craig, de Haan, Lieuwe, Reininghaus, Ulrich, Cardno, Alastair G., Di Forti, Marta, Murray, Robin M., Quattrone, Diego, Hersenen-Medisch 1, Brain, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Sanchez-Gutierrez, Teresa, Tripoli, Giada, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Sideli, Lucia, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, Del-Ben, Cristina Marta, Gayer-Anderson, Charlotte, Jongsma, Hannah E., Kirkbride, James B., Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre Michel, Menezes, Paulo Rossi, Rutten, Bart P., Santos, Jose Luis, Sanjuán, Julio, Selten, Jean Paul, Szöke, Andrei, Tarricone, Ilaria, Muratori, Roberto, Tortelli, Andrea, Velthorst, Eva, Rodriguez, Victoria, Quattrone, Andrea, Jones, Peter B., Van Os, Jim, Vassos, Evangelos, Morgan, Craig, de Haan, Lieuwe, Reininghaus, Ulrich, Cardno, Alastair G., Di Forti, Marta, Murray, Robin M., and Quattrone, Diego
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- 2021
15. Migration history and risk of psychosis: results from the multinational EU-GEI study
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Tarricone, Ilaria, primary, D'Andrea, Giuseppe, additional, Jongsma, Hannah E., additional, Tosato, Sarah, additional, Gayer-Anderson, Charlotte, additional, Stilo, Simona A., additional, Suprani, Federico, additional, Iyegbe, Conrad, additional, van der Ven, Els, additional, Quattrone, Diego, additional, di Forti, Marta, additional, Velthorst, Eva, additional, Rossi Menezes, Paulo, additional, Arango, Celso, additional, Parellada, Mara, additional, Lasalvia, Antonio, additional, La Cascia, Caterina, additional, Ferraro, Laura, additional, Bobes, Julio, additional, Bernardo, Miguel, additional, Sanjuán, Iulio, additional, Santos, Jose Luis, additional, Arrojo, Manuel, additional, Del-Ben, Cristina Marta, additional, Tripoli, Giada, additional, Llorca, Pierre-Michel, additional, de Haan, Lieuwe, additional, Selten, Jean-Paul, additional, Tortelli, Andrea, additional, Szöke, Andrei, additional, Muratori, Roberto, additional, Rutten, Bart P., additional, van Os, Jim, additional, Jones, Peter B., additional, Kirkbride, James B., additional, Berardi, Domenico, additional, Murray, Robin M., additional, and Morgan, Craig, additional
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- 2021
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16. Gioco responsabile e comportamenti di salute: un progetto di ricerca e intervento in Emilia-Romagna
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Tarricone, Ilaria, primary, Cesa, Federico, additional, Suprani, Federico, additional, Russo, Giovanna, additional, Muratori, Roberto, additional, and Domenicali, Marco, additional
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- 2020
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17. Childhood medical history and psychosis in adult life: Findings from the Bologna EU‐GEI incidence and case–control study
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D'Andrea, Giuseppe, primary, Suprani, Federico, additional, Tolomelli, Elena, additional, Gennari, Monia, additional, Lanari, Marcello, additional, Faldella, Giacomo, additional, Muratori, Roberto, additional, Berardi, Domenico, additional, and Tarricone, Ilaria, additional
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- 2020
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18. Multiplexed therapeutic drug monitoring of antipsychotics in dried plasma spots by LC‐MS/MS
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Ruggiero, Carla, primary, Ramirez, Stefania, additional, Ramazzotti, Eric, additional, Mancini, Rita, additional, Muratori, Roberto, additional, Raggi, Maria Augusta, additional, and Conti, Matteo, additional
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- 2020
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19. SELF-harm and mIgration (SELF-mI) study: Results from one-year psychiatric admissions' study in Bologna, Italy
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Iuzzolino, Gianmarco, primary, Tarricone, Ilaria, additional, Petio, Carmine, additional, Oggiorni, Alessandro, additional, Toniolo, Irene, additional, Belsito, Cristina, additional, Trappoli, Angela, additional, Montalbano, Giovanni, additional, Lal, Jatin, additional, and Muratori, Roberto, additional
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- 2019
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20. Childhood medical history and psychosis in adult life: Findings from the Bologna EU‐GEI incidence and case–control study.
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D'Andrea, Giuseppe, Suprani, Federico, Tolomelli, Elena, Gennari, Monia, Lanari, Marcello, Faldella, Giacomo, Muratori, Roberto, Berardi, Domenico, and Tarricone, Ilaria
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CASE-control method ,LOGISTIC regression analysis ,PSYCHOSES ,ODDS ratio - Abstract
Aim: To estimate the association between the inpatient admissions and Emergency Department (ED) visits before age of 18 years and adulthood‐onset first‐episode psychosis (FEP). Methods: We conducted a FEP incidence and case–control study and calculated the odds ratios (ORs) for incident FEP associated with inpatient admissions and ED visits prior to age of 18 years, adjusting our results for cannabis use, parental socio‐economic class and childhood trauma. Results: In multivariate logistic regression analysis, odds of FEP increased significantly if the participant had a history of at least one inpatient admission (OR = 3.52; 95% confidence interval [95%CI] 1.07‐11.54; P =.04) or at least one ED visit (OR = 8.93; 95%CI 2.41‐33.14; P =.001) before age of 18. The associations remained significant adjusting for cannabis use, education, parental socio‐economic class and childhood trauma. Conclusion: Consistently with the socio‐neurodevelopmental model, we found a significant association between a positive history of hospital care in childhood and adulthood‐onset psychosis. [ABSTRACT FROM AUTHOR]
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- 2021
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21. Prevalence and effectiveness of psychiatric treatments for patients with IBD: A systematic literature review
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Giovanni Carini, Maria Giulia Regazzi, Gilberto Poggioli, Massimo Campieri, Giulia Bonucci, Ilaria Tarricone, Fernando Rizzello, Roberto Muratori, Tarricone, Ilaria, Regazzi, Maria Giulia, Bonucci, Giulia, Rizzello, Fernando, Carini, Giovanni, Muratori, Roberto, Poggioli, Gilberto, and Campieri, Massimo
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Adult ,Male ,medicine.medical_specialty ,Population ,MEDLINE ,Antidepressant ,Disease ,Anxiety ,Inflammatory bowel disease ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Crohn Disease ,Prevalence ,Humans ,Medicine ,030212 general & internal medicine ,education ,Psychiatry ,Depression (differential diagnoses) ,education.field_of_study ,Depression ,business.industry ,Psychoactive drug ,Psycho-pharmacological treatment ,Inflammatory Bowel Diseases ,medicine.disease ,digestive system diseases ,Psychotherapy ,Psychiatry and Mental health ,Clinical Psychology ,Systematic review ,Quality of Life ,Colitis, Ulcerative ,Female ,030211 gastroenterology & hepatology ,medicine.symptom ,business ,medicine.drug ,Clinical psychology - Abstract
Objectives Higher prevalence of psychiatric disorders, such as anxiety and depression, has been found in people with Crohn's disease and Ulcerative Colitis compared to the general population. Nowadays, international guidelines advocate psychotherapy and psycho-pharmacological treatments as playing an important role in IBD care. The main goal of this systematic literature review was summarize the evidence on the utilization and effectiveness of treatments for depression and anxiety in persons with IBD. Methods A systematic literature review was conducted using three different electronic databases: MEDLINE, PsychINFO, and EMBASE to identify studies reporting the prevalence and efficacy of psycho-pharmacological and psychotherapeutic treatments for IBD. A quality appraisal was conducted using several scales as appropriate for each study design. A narrative synthesis was also performed. Results Forty-three studies were included. Although a high rate of psychoactive drug use was found in people with IBD, a low proportion of IBD patients have access to psychiatric referral. 1/3 of the studies found that psychotherapy was effective for improving the quality of life, perception of stress, anxiety and depression as well as disease. Antidepressants proved effective in reducing disease activity, gastrointestinal symptoms, anxiety and depression. Conclusion Our results suggest that psychiatric treatment should be implemented in IBD care. However, further studies are needed to confirm the findings of our systematic review.
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- 2017
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22. Pathways to care: Source of referral at first-episode psychosis, a cross-country comparison between Bologna and South London.
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Oduola S, D'Andrea G, Smimmo D, Menchetti M, Berardi D, Muratori R, Murray R, Di Forti M, Lucchi F, Morgan C, and Tarricone I
- Abstract
Objectives: Pathways to Care (PtC) are useful indicators of how patients access mental healthcare, especially in the context of first-episode psychosis (FEP). We explored how PtC: source of referral, is associated with patients' characteristics and clinical presentation and assessed the cross-country differences of the PtC predictors between South London and Bologna., Methods: This study included 427 FEP individuals in the context of the European Union Gene-Environment Interactions (EU-GEI) study. We performed multinomial logistic regression to test the associations between our outcome variables (PtC) and the independent study variables., Results: In London, patients were more likely to be referred by GPs or specialists, while in Bologna, most patients followed the emergency route. Despite the study centre differences, older patients were more likely to be referred by GPs; patients referred informally and via specialist services were more likely to be single. Compared with emergency referrals, patients referred by GPs and specialists experienced a longer DUP. We found insufficient evidence of an association between symptoms profile and PtC., Conclusions: PtC characteristics of FEP patients were associated with several sociodemographic and DUP in both study centres. Our results highlight the importance of social networks and social services and public engagement, and public health initiatives (such as psychoeducation in schools and leisure centres) in easing help-seeking behaviours., Competing Interests: Declaration of competing interest None., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
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- 2024
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23. Child maltreatment, migration and risk of first-episode psychosis: results from the multinational EU-GEI study.
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D'Andrea G, Lal J, Tosato S, Gayer-Anderson C, Jongsma HE, Stilo SA, van der Ven E, Quattrone D, Velthorst E, Berardi D, Rossi Menezes P, Arango C, Parellada M, Lasalvia A, La Cascia C, Ferraro L, La Barbera D, Sideli L, Bobes J, Bernardo M, Sanjuán J, Santos JL, Arrojo M, Del-Ben CM, Tripoli G, Llorca PM, de Haan L, Selten JP, Tortelli A, Szöke A, Muratori R, Rutten BP, van Os J, Jones PB, Kirkbride JB, Murray RM, di Forti M, Tarricone I, and Morgan C
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- Child, Humans, Ethnicity, Incidence, Psychotic Disorders epidemiology, Transients and Migrants, Child Abuse
- Abstract
Background: Child maltreatment (CM) and migrant status are independently associated with psychosis. We examined prevalence of CM by migrant status and tested whether migrant status moderated the association between CM and first-episode psychosis (FEP). We further explored whether differences in CM exposure contributed to variations in the incidence rates of FEP by migrant status., Methods: We included FEP patients aged 18-64 years in 14 European sites and recruited controls representative of the local populations. Migrant status was operationalized according to generation (first/further) and region of origin (Western/non-Western countries). The reference population was composed by individuals of host country's ethnicity. CM was assessed with Childhood Trauma Questionnaire. Prevalence ratios of CM were estimated using Poisson regression. We examined the moderation effect of migrant status on the odds of FEP by CM fitting adjusted logistic regressions with interaction terms. Finally, we calculated the population attributable fractions (PAFs) for CM by migrant status., Results: We examined 849 FEP cases and 1142 controls. CM prevalence was higher among migrants, their descendants and migrants of non-Western heritage. Migrant status, classified by generation (likelihood test ratio:χ
2 = 11.3, p = 0.004) or by region of origin (likelihood test ratio:χ2 = 11.4, p = 0.003), attenuated the association between CM and FEP. PAFs for CM were higher among all migrant groups compared with the reference populations., Conclusions: The higher exposure to CM, despite a smaller effect on the odds of FEP, accounted for a greater proportion of incident FEP cases among migrants. Policies aimed at reducing CM should consider the increased vulnerability of specific subpopulations.- Published
- 2023
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24. Migration history and risk of psychosis: results from the multinational EU-GEI study.
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Tarricone I, D'Andrea G, Jongsma HE, Tosato S, Gayer-Anderson C, Stilo SA, Suprani F, Iyegbe C, van der Ven E, Quattrone D, di Forti M, Velthorst E, Rossi Menezes P, Arango C, Parellada M, Lasalvia A, La Cascia C, Ferraro L, Bobes J, Bernardo M, Sanjuán I, Santos JL, Arrojo M, Del-Ben CM, Tripoli G, Llorca PM, de Haan L, Selten JP, Tortelli A, Szöke A, Muratori R, Rutten BP, van Os J, Jones PB, Kirkbride JB, Berardi D, Murray RM, and Morgan C
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- Humans, Case-Control Studies, Ethnicity, Psychotic Disorders epidemiology, Schizophrenia epidemiology, Schizophrenia etiology, Transients and Migrants
- Abstract
Background: Psychosis rates are higher among some migrant groups. We hypothesized that psychosis in migrants is associated with cumulative social disadvantage during different phases of migration., Methods: We used data from the EUropean Network of National Schizophrenia Networks studying Gene-Environment Interactions (EU-GEI) case-control study. We defined a set of three indicators of social disadvantage for each phase: pre-migration, migration and post-migration. We examined whether social disadvantage in the pre- and post-migration phases, migration adversities, and mismatch between achievements and expectations differed between first-generation migrants with first-episode psychosis and healthy first-generation migrants, and tested whether this accounted for differences in odds of psychosis in multivariable logistic regression models., Results: In total, 249 cases and 219 controls were assessed. Pre-migration (OR 1.61, 95% CI 1.06-2.44, p = 0.027) and post-migration social disadvantages (OR 1.89, 95% CI 1.02-3.51, p = 0.044), along with expectations/achievements mismatch (OR 1.14, 95% CI 1.03-1.26, p = 0.014) were all significantly associated with psychosis. Migration adversities (OR 1.18, 95% CI 0.672-2.06, p = 0.568) were not significantly related to the outcome. Finally, we found a dose-response effect between the number of adversities across all phases and odds of psychosis (⩾6: OR 14.09, 95% CI 2.06-96.47, p = 0.007)., Conclusions: The cumulative effect of social disadvantages before, during and after migration was associated with increased odds of psychosis in migrants, independently of ethnicity or length of stay in the country of arrival. Public health initiatives that address the social disadvantages that many migrants face during the whole migration process and post-migration psychological support may reduce the excess of psychosis in migrants.
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- 2022
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