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608 results on '"Murata R"'

1. 180$^\circ$-twisted bilayer ReSe$_2$ as an artificial noncentrosymmetric semiconductor

Author

Akatsuka, S., Sakano, M., Yamamoto, T., Nomoto, T., Arita, R., Murata, R., Sasagawa, T., Watanabe, K., Taniguchi, T., Kitamura, M., Horiba, K., Sugawara, K., Souma, S., Sato, T., Kumigashira, H., Shinokita, K., Wang, H., Matsuda, K., Masubuchi, S., Machida, T., and Ishizaka, K.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We have fabricated a 180$^\circ$-twisted bilayer ReSe$_2$ by stacking two centrosymmetric monolayer ReSe$_2$ flakes in opposite directions, which is expected to lose spatial inversion symmetry. By the second harmonic generation and angle-resolved photoemission spectroscopy, we successfully observed spatial inversion symmetry breaking and emergent band dispersions. The band calculation shows the finite lifting of spin degeneracy (~50 meV) distinct from natural monolayer and bilayer ReSe$_2$. Our results demonstrate that the spin-momentum locked state, which leads to spintronic functions and Berry-curvature-related phenomena, can be realized even with the stacking of centrosymmetric monolayers., Comment: 15 pages, 4 figures

Published
2023

2. Neopterin Concentrations of Serum and Cerebrospinal Fluid in Febrile Convulsion, Aseptic Meningitis and Influenza Encephalopathy

Author

Shiomi M., Togawa M., Kurimasa H., Kawawaki H., Tomiwa K., Sawada Y., Shintaku H., Asada M., and Murata R.

Subjects
neopterin, cerebrospinal fluid, encephalopathy, febrile convulsion, influenza, aseptic meningitis, human herpes virus 6, Crystallography, QD901-999
Abstract

The concentration of total neopterin in serum and cerebrospinal fluid (CSF) was measured in cases of febrile convulsion, aseptic meningitis and influenza encephalopathy. In febrile convulsion except for exanthem subitum, the concentrations of CSF neopterin (26± 11, Mean±SD, n=6) were all within normal range while those of serum neopterin (66± 20, n=8) were significantly higher (p < 0.05). In aseptic meningitis, on the other hand, the concentrations of CSF neopterin (194± 130, n=13) were significantly higher than those of serum (33±23, n=11, p < 0.05). In influenza encephalopathy, both concentrations of serum neopterin (329±478, n=13) and CSF neopterin(179±131, n=11) were much higher than the control range. Our results indicate that the primary immunoreacting site is the central nervous system (CNS) for aseptic meningitis, the periphery for febrile convulsion except for exanthem subitum and both the periphery and the CNS for influenza encephalopathy. Measurements of neopterin concentrations in CSF as well as in serum may thus constitute an immediate aid for early differentiation of CNS infection from peripheral infection as well as for early detection of viral encephalopathy caused by viruses such as the influenza virus or the human herpes virus 6.

Published
1999
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3. The Hyper Suprime-Cam SSP Survey: Overview and Survey Design

Author

Aihara, H., Arimoto, N., Armstrong, R., Arnouts, S., Bahcall, N. A., Bickerton, S., Bosch, J., Bundy, K., Capak, P. L., Chan, J. H. H., Chiba, M., Coupon, J., Egami, E., Enoki, M., Finet, F., Fujimori, H., Fujimoto, S., Furusawa, H., Furusawa, J., Goto, T., Goulding, A., Greco, J. P., Greene, J. E., Gunn, J. E., Hamana, T., Harikane, Y., Hashimoto, Y., Hattori, T., Hayashi, M., Hayashi, Y., Hełminiak, K. G., Higuchi, R., Hikage, C., Ho, P. T. P., Hsieh, B. -C., Huang, K., Huang, S., Ikeda, H., Imanishi, M., Inoue, A. K., Iwasawa, K., Iwata, I., Jaelani, A. T., Jian, H. -Y., Kamata, Y., Karoji, H., Kashikawa, N., Katayama, N., Kawanomoto, S., Kayo, I., Koda, J., Koike, M., Kojima, T., Komiyama, Y., Konno, A., Koshida, S., Koyama, Y., Kusakabe, H., Leauthaud, A., Lee, C. -H., Lin, L., Lin, Y. -T., Lupton, R. H., Mandelbaum, R., Matsuoka, Y., Medezinski, E., Mineo, S., Miyama, S., Miyatake, H., Miyazaki, S., Momose, R., More, A., More, S., Moritani, Y., Moriya, T. J., Morokuma, T., Mukae, S., Murata, R., Murayama, H., Nagao, T., Nakata, F., Niida, M., Niikura, H., Nishizawa, A. J., Obuchi, Y., Oguri, M., Oishi, Y., Okabe, N., Okura, Y., Ono, Y., Onodera, M., Onoue, M., Osato, K., Ouchi, M., Price, P. A., Pyo, T. -S., Sako, M., Okamoto, S., Sawicki, M., Shibuya, T., Shimasaku, K., Shimono, A., Shirasaki, M., Silverman, J. D., Simet, M., Speagle, J., Spergel, D. N., Strauss, M. A., Sugahara, Y., Sugiyama, N., Suto, Y., Suyu, S. H., Suzuki, N., Tait, P. J., Takata, T., Takada, M., Tamura, N., Tanaka, M. M., Tanaka, M., Tanaka, Y., Terai, T., Terashima, Y., Toba, Y., Toshikawa, J., Turner, E. L., Uchida, T., Uchiyama, H., Umetsu, K., Uraguchi, F., Urata, Y., Usuda, T., Utsumi, Y., Wang, S. -Y., Wang, W. -H., Wong, K. C., Yabe, K., Yamada, Y., Yamanoi, H., Yasuda, N., Yeh, S., Yonehara, A., and Yuma, S.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Hyper Suprime-Cam (HSC) is a wide-field imaging camera on the prime focus of the 8.2m Subaru telescope on the summit of Maunakea in Hawaii. A team of scientists from Japan, Taiwan and Princeton University is using HSC to carry out a 300-night multi-band imaging survey of the high-latitude sky. The survey includes three layers: the Wide layer will cover 1400 deg$^2$ in five broad bands ($grizy$), with a $5\,\sigma$ point-source depth of $r \approx 26$. The Deep layer covers a total of 26~deg$^2$ in four fields, going roughly a magnitude fainter, while the UltraDeep layer goes almost a magnitude fainter still in two pointings of HSC (a total of 3.5 deg$^2$). Here we describe the instrument, the science goals of the survey, and the survey strategy and data processing. This paper serves as an introduction to a special issue of the Publications of the Astronomical Society of Japan, which includes a large number of technical and scientific papers describing results from the early phases of this survey., Comment: 14 pages, 7 figures, 5 tables. Corrected for a typo in the coordinates of HSC-Wide spring equatorial field in Table 5

Published
2017
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6. Corrigendum to “Prognostic value of sequencing-based minimal residual disease detection in patients with multiple myeloma who underwent autologous stem-cell transplantation”

Author

Takamatsu, H., primary, Takezako, N., additional, Zheng, J., additional, Moorhead, M., additional, Carlton, V.E.H., additional, Kong, K.A., additional, Murata, R., additional, Ito, S., additional, Miyamoto, T., additional, Yokoyama, K., additional, Matsue, K., additional, Sato, T., additional, Kurokawa, T., additional, Yagi, H., additional, Terasaki, Y., additional, Ohata, K., additional, Matsumoto, M., additional, Yoshida, T., additional, Faham, M., additional, and Nakao, S., additional

Published
2022
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9. Multilayer dual-band bandpass filter in low-temperature co-fired ceramic substrate for ultra-wideband applications

Author

Oshima, S., Wada, K., Murata, R., and Shimakata, Y.

Subjects
Attenuation -- Analysis, Electric filters, Bandpass -- Design and construction, Ceramic materials -- Thermal properties, Ceramic materials -- Electric properties, Ceramics -- Thermal properties, Ceramics -- Electric properties, Ultra wideband technology -- Analysis, Business, Computers, Electronics, Electronics and electrical industries
Published
2010

23. Introduction of WT-TP53 into pancreatic cancer cells alters sensitivity to chemotherapeutic drugs, targeted therapeutics and nutraceuticals

Author

Abrams, S., Lertpiriyapong, K., Yang, L., Martelli, A., Cocco, L., Ratti, S., Falasca, Marco, Murata, R., Rosalen, P., Lombardi, P., Libra, M., Candido, S., Montalto, G., Cervello, M., Steelman, L., McCubrey, J., Abrams, S., Lertpiriyapong, K., Yang, L., Martelli, A., Cocco, L., Ratti, S., Falasca, Marco, Murata, R., Rosalen, P., Lombardi, P., Libra, M., Candido, S., Montalto, G., Cervello, M., Steelman, L., and McCubrey, J.

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, highly metastatic malignancy and accounts for 85% of pancreatic cancers. PDAC patients have poor prognosis with a five-year survival of only 5–10%. Mutations at the TP53 gene are readily detected in pancreatic tumors isolated from PDAC patients. We have investigated the effects of restoration of wild-type (WT) TP53 activity on the sensitivity of pancreatic cancer cells to: chemotherapy, targeted therapy, as well as, nutraceuticals. Upon introduction of the WT-TP53 gene into the MIA-PaCa-2 pancreatic cancer cell line, the sensitivity to drugs used to treat pancreatic cancer cells such as: gemcitabine, fluorouracil (5FU), cisplatin, irinotecan, oxaliplatin, and paclitaxel increased significantly. Likewise, the sensitivity to drugs used to treat other cancers such as: doxorubicin, mitoxantrone, and 4 hydroxy tamoxifen (4HT) also increased upon introduction of WT-TP53 into MIA-PaCa-2 cells. Furthermore, the sensitivity to certain inhibitors which target: PI3K/mTORC1, PDK1, SRC, GSK-3, and biochemical processes such as proteasomal degradation and the nutraceutical berberine as increased upon introduction of WT-TP53. Furthermore, in some cases, cells with WT-TP53 were more sensitive to the combination of drugs and suboptimal doses of the MDM2 inhibitor nutlin-3a. However, TP53-independent effects of nutlin-3a were observed upon treatment with either a proteasomal or a PI3K/mTOR inhibitor. These studies indicate the sensitizing effects that WT-TP53 can have in PDAC cells which normally lack WT-TP53 to various therapeutic agents and suggest approaches to improve PDAC therapy.

Published
2018

33. LETTERS.

Author

CRUIKSHANK, ROBIN, MAY WARNE, IVA, HALL ROE, F., SMITH, LOUISE, MORRIS, DAVID D., SCHEINFELD FRANK, R.UHAMAH, MURATA, R., WOLOWITZ, HAROLD, COLE, JAMES E., RIORDAN, JACK M., POPE JR., BENJAMIN, RYMER, R. W., SOHN, ROBERT M., MCAULEY, JOHN E., PANIGUIAN, H., and FORTH, PATRICIA V.

Subjects
WORLD War II, DEMOCRACY
Published
1947

38. [Seizures associated with fever in children of congenital adrenal hyperplasia]

Author

Kawawaki H, Satoshi Kusuda, Kurimasa H, Tomiwa K, and Murata R

Subjects
Male, Adrenal Hyperplasia, Congenital, Cytochrome P-450 Enzyme System, Corticotropin-Releasing Hormone, Child, Preschool, Humans, Infant, Female, Steroid 21-Hydroxylase, Child, Seizures, Febrile
Abstract

We investigated seizures in 22 children with congenital adrenal hyperplasia (CAH), eight of whom had seizures associated with fever. The follow-up period was 5-18 years. The onset of seizures ranged from 1 to 4 years of age, and the total number of seizures was one to three in all cases. Four cases had seizures twice within 24 hours. None had seizures after 5 years of age. In two of the eight cases, the seizures may have caused by hypoglycemia or hyponatremia, in the remaining six they were considered to be febrile seizures. Three of them had first-degree relatives with febrile seizures. Electroencephalogram was recorded in five cases, with normal results in all of them. One case with febrile status developed localization-related epilepsy later. None showed developmental delay during follow-up. Although seizures in CAH have been ascribed to hypoglycemia and/or metabolic disorders (hyponatremia), our findings implicate unknown factors in the pathogenesis such as excess secretion of corticotropin releasing factor (CRF) under stress, prolonged elevation of CRF during fetus life and linkage between CAH and febrile seizures on the chromosome 6.

Published
2001

41. Combretastatins novel vascular targeting drugs for improving anti-cancer therapy. Combretastatins and conventional therapy

Author

Horsman, Michael Robert, Murata, R, Breidahl, Tomas, Nielsen, F U, Maxwell, R J, Stødkilde-Jørgensen, Hans, Overgaard, Jens, and Maragoudakis, Michael E.

Subjects
Heating, Mice, Mice, Inbred C3H, Antineoplastic Combined Chemotherapy Protocols, Stilbenes, Animals, Mammary Neoplasms, Experimental, Drug Therapy, Combination, Female, Cisplatin, Antineoplastic Agents, Phytogenic, Combined Modality Therapy
Abstract

Combretastatins are a new class of compounds that appear to have anti-tumour activity as a result of specifically targeting the vasculature of tumours. The aim of this study was to investigate the potential of combretastatin A-4 disodium phosphate (CA4DP) to induce vascular effects in a C3H mouse mammary carcinoma, and to see if the anti-tumour response could be improved by combining the drug with conventional anti-cancer therapies. It was found that CA4DP (250 mg/kg) significantly decreased tumour perfusion within 30 minutes after injection and maintained this decrease for several hours, although there was a return to normal by 24 hours. Similar changes were seen in the tumours bioenergetic and oxygenation status. The drug also significantly increased tumour necrosis and had a small inhibitory effect on tumour growth. It was also able to enhance the tumour response to radiation and hyperthermia, when given at the same time or 30 minutes after the radiation and hyperthermia, respectively. Giving the drug 1 hour after cisplatin injection only resulted in a tumour response that was no greater than additive. These results confirm the anti-vascular effects of CA4DP and demonstrate its potential to enhance the anti-tumour activity of conventional therapy.

Published
2000

43. Electronic phase transition in hollandite titanates BaxTi8O16+δ.

Author

Murata, R., Sato, T., Okuda, T., Horibe, Y., Tsukasaki, H., Mori, S., Yamaguchi, N., Sugimoto, K., Kawaguchi, S., Takata, M., and Katsufuji, T.

Subjects
*PHASE transitions, *BARIUM titanate, *OPTICAL conductivity, *ELECTRONS, *OPTICAL modulation
Abstract

We studied the physical properties of hollandite titanates, BaxTi8O16+δ, which have double chains of edgesharing TiO6 octahedra with d electrons in the t2g states. We found that there is an electronic phase transition at ~220 K, at which various properties exhibit anomalies. This phase transition is characterized by a modulation in the TiO6 chains and a spectral weight transfer of over 2 eV in the optical conductivity spectrum, which are presumably caused by charge and orbital ordering of the Ti t2g electrons. [ABSTRACT FROM AUTHOR]

Published
2015
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44. Tirapazamine: hypoxic cytotoxicity and interaction with radiation as assessed by the micronucleus assay

Author

Shibata, T., Shibamoto, Y., Sasai, K., Oya, N., Murata, R., Takagi, T., Hiraoka, M., Takahashi, M., and Abe, M.

Subjects
Radiation-Sensitizing Agents, Micronucleus Tests, Triazines, Antineoplastic Agents, Dose-Response Relationship, Radiation, Cell Hypoxia, Mice, Nitroimidazoles, Tumor Cells, Cultured, Animals, Humans, Tirapazamine, Micronuclei, Chromosome-Defective, Research Article
Abstract

We investigated the cytotoxicity and the interaction with low-dose radiation (1-4Gy) of tirapazamine by the in vitro cytokinesis-block micronucleus (MN) assay. Murine SCCVII and human melanoma (G-361) cells were treated with tirapazamine under aerobic or hypoxic conditions for 1 h and the MN frequency was determined using cytochalasin-B. The cells were also treated with or without tirapazamine or KU-2285 (hypoxic cell sensitiser) under hypoxic conditions and irradiated with or without reaeration of the cell suspensions. A dose-dependent increase of MN frequency was observed by tirapazamine treatment and the hypoxic toxicity ratio was about 130 for SCCVII and 37 for G-361. The radiation dose-response curves of MN frequency suggested that the interaction of tirapazamine with irradiation appeared to be essentially additive in both cell lines. In contrast, the dose-response curve became steeper by KU-2285 treatment. Combined effects of tirapazamine and irradiation on the hypoxic cells were much higher than the radiation effect on aerobic cells at low doses, while the effects of KU-2285 did not exceed that of aerobic irradiation. In conclusion, tirapazamine appeared to be superior to hypoxic radiosensitisers at clinically relevant doses, not because of aerobic radiosensitisation but because of its potent hypoxic cytotoxicity additive to radiation effect.

Published
1996

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