112 results on '"Murat Borlu"'
Search Results
2. Disease burden, clinical management and unmet treatment need of patients with moderate to severe alopecia areata; consensus statements, insights, and practices from CERTAAE (Central/Eastern EU, Russia, Türkiye AA experts) Delphi panel
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Lidia Rudnicka, Magdalena Trzeciak, Erkan Alpsoy, Petr Arenberger, Sibel Alper, Nina Benáková, Svetlana Bobko, Murat Borlu, Magdalena Czarnecka Operacz, Burhan Engin, Tülin Ergun, Ilgen Ertam Sağduyu, Olga Filipovská, Aida Gadzhigoroeva, Martina Kojanová, Aleksandra Lesiak, Anna Michenko, Nikolay Murashkin, Nahide Onsun, Witold Owczarek, Zuzana Plzakova, Adam Reich, Marie Selerová, and Burcu Aybike Gürbüz
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alopecia areata ,disease burden ,diagnosis ,treatment ,clinical management ,Medicine (General) ,R5-920 - Abstract
ObjectivesThis study aims to update the understanding of Alopecia Areata (AA) in Poland, Czechia, Russia, and Türkiye, focusing on the disease burden, clinical management, and patient journey. It seeks to establish a consensus on optimal management strategies for AA in these regions.MethodsA modified 2-round Delphi panel was conveyed with 23 Dermatologists (Russia; 4, Türkiye; 7, Poland; 6, and Czechia; 6). The Delphi questionnaire consisted of 61 statements and 43 questions designed to obtain an overall understanding of the perception and acceptance of available information regarding the care of patients with alopecia areata.ResultsThe study revealed that moderate-to-severe AA significantly impacts patients’ and their families’ QoL, consistent with previous studies. AA was found to cause more substantial impairment when additional lesions appeared in visible areas besides the scalp. Work and productivity impairment were notably higher in adults with moderate-to-severe AA. Diagnostic consensus highlighted the importance of skin biopsies and trichoscopy, while the need for more practical severity scoring systems was emphasized. Current treatments, including topical therapies, corticosteroids, and systemic immune modifiers, were deemed insufficient, highlighting the unmet medical need.ConclusionThe Delphi study underscores a significant disease burden and unmet medical needs in patients with moderate-to-severe AA. It highlights the necessity of access to novel treatments and further research to develop more effective therapies with a tolerable safety profile. The findings align with global research, emphasizing the psychosocial impact of AA and the need for standardized, effective treatment protocols.
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- 2024
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3. Atopic dermatitis diagnosis and treatment consensus report
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Nilgün Atakan, Başak Yalçın, Esen Özkaya, Özlem Su Küçük, Serap Öztürkcan, Andaç Salman, Murat Borlu, Nilgün Şentürk, Ayşe Akman-Karakaş, and Server Serdaroğlu
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atopic dermatitis ,guideline ,diagnosis ,topical treatment ,systemic treatment ,Dermatology ,RL1-803 ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Atopic dermatitis (AD) is a chronic, itchy, and recurrent inflammatory skin disease. AD, which is known as a childhood disease because of its common occurrence, is also an important health problem in adults. With increasing prevalence rates throughout each year, particularly in developed countries, AD has a heterogeneous clinical presentation that varies with age and different degrees of severity. The treatment includes the use of topical or systemic agents after identifying the needs of the patients. Especially, the identification of molecules responsible for pathogenesis recently has allowed the development of tailored treatments. With a better understanding of both the disease and the economic burden of AD recently, studies have gained momentum on diagnosis, treatment, and quality of life. Guidelines and consensus reports addressing diagnostic and therapeutic approaches have been published in our country, too, in parallel to publications in various countries. In this age of rapid information sharing, all kinds of information need to be updated frequently and become further useful. For this purpose, it is planned to develop a current consensus guideline under the leadership of the Dermatoimmunology and Allergy Association, with the contributions of the Cosmetology and the Dermatology Academy Association, Kayseri Dermatology and the Venereal Diseases Association, and Manisa Dermatology and the Venereal Diseases Association, and through the participation of faculty members experienced in the diagnosis and treatment of AD. The topics and the authors were chosen in December 2020. All Medline data published in the years between 1980 and 2021, current AD diagnosis and treatment guidelines, meta-analytical studies, and expert opinions and experiences were reviewed, and section drafts were developed. Literature data and section drafts were assessed and discussed during a meeting held in March 2021 with the participation of all authors. Then, the sections were finalized via e-mail correspondences and submitted as a final consensus report.
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- 2022
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4. The impact of COVID-19 pandemic on psoriasis patients, and their immunosuppressive treatment: a cross-sectional multicenter study from Turkey
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Selda Pelin Kartal, Gökçen Çelik, Oğuz Yılmaz, Eda Öksüm Solak, Büşra Demirbağ Gül, Tuba Kevser Üstünbaş, Melis Gönülal, Sevim Baysak, Esma İnan Yüksel, Begüm Ünlü, Münevver Güven, Ali Bozdağ, Gökhan Çınar, Selim Kartal, Murat Borlu, Müge Güler Özden, Burhan Engin, Server Serdaroğlu, Didem Didar Balcı, Bilal Doğan, Demet Çiçek, Ayça Cordan Yazıcı, Sema Aytekin, Neslihan Şendur, Hayriye Sarıcaoglu, Nida Gelincik Kaçar, Asena Cigdem Doğramacı, Levent Dönmez, and Erkan Alpsoy
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covid-19 ,psoriasis ,immunosuppressive drugs ,biologics ,treatment adherence ,Dermatology ,RL1-803 - Abstract
Background Immunosuppressive therapy has been a great concern during the pandemic. This study aimed to evaluate the pandemic's impact on psoriasis patients treated with immunosuppressive drugs. Material and Methods The multicenter study was conducted in 14 tertiary dermatology centers. Demographic data, treatment status, disease course, and cases of COVID-19 were evaluated in patients with psoriasis using the immunosuppressive treatment. Results Of 1827 patients included, the drug adherence rate was 68.2%. Those receiving anti-interleukin (anti-IL) drugs were more likely to continue treatment than patients receiving conventional drugs (OR = 1.50, 95% CI, 1.181–1.895, p = .001). Disease worsening rate was 24.2% and drug dose reduction increased this rate 3.26 and drug withdrawal 8.71 times. Receiving anti-TNF or anti-IL drugs was associated with less disease worsening compared to conventional drugs (p = .038, p = .032; respectively). Drug withdrawal causes were ‘unable to come’ (39.6%), ‘COVID concern’ (25.3%), and ‘physician’s and patient’s co-decision’ (17.4%). Four patients had COVID-19 infection with mild symptoms. The incidence was 0.0022% while it was 0.0025% in the general population. Conclusion Our study shows that psoriasis patients using systemic immunosuppressive do not have a higher, but even lower COVID-19 risk than the general population, and treatment compliance with biological drugs is higher.
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- 2022
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5. Ustekinumab
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Murat Borlu
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anti-il-12/23 ,p40 ,ustekinumab ,Dermatology ,RL1-803 ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Ustekinumab is an antagonistic human monoclonal immunoglobulin G1 antibody that targets p40, a common subunit of interleukin-12 (IL-12) and IL-23. In clinical trials, 66-81% of the patients using ustekinumab achieved a PASI75 response. Its long drug survival time has been found remarkable in real-world experiences. Other advantages of ustekinumab include ease of use in obese patients as its dose can be adjusted according to body weight and its administration every 12 weeks in the maintenance period.
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- 2022
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6. Varicella-like Lesions in a Patient with Aggressive Lupus Nephritis
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Sümeyra Koyuncu, Hülya Durmuş, Eda Öksüm Solak, İsmail Koçyiğit, Murat Borlu, Özlem Canöz, and Bülent Tokgöz
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Internal medicine ,RC31-1245 ,Pediatrics ,RJ1-570 - Published
- 2022
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7. Brodalumab
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Murat Borlu
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anti-il-17ra ,brodalumab ,psoriasis ,Dermatology ,RL1-803 ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Brodalumab is a human monoclonal antibody that inhibits interleukin-17 (IL-17) pathway by binding to IL-17 receptor. In clinical trials, a PASI75 response has been achieved in 82-84% of the patients at week 12. It was shown to be effective also in generalized pustular and erythrodermic psoriasis. As with other IL-17 inhibitors, brodalumab should be used with caution in patients with inflammatory bowel disease.
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- 2022
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8. Nekrobiosis Lipoidica in a Pediatric Patient
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Gözde Emel Gökçek, Özge Şeyda Saka, Emine Colgecen, Murat Borlu, and Özlem Canöz
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necrobiosis lipoidica ,type 1 diabetes ,children ,diabetes ,granulomatous dermatitis ,Pediatrics ,RJ1-570 - Abstract
Necrobiosis lipoidica is a rare chronic granulomatous disease that has historically been associated with diabetes mellitus, but recently it is thought to be secondary to microangiopathic changes. We report a necrobiosis lipoidica case of a five-year-old girl with diabetes since the age of two, because it is exceptionally unusual in pediatric diabetes. Necrobiosis lipoidica should be considered in pediatric patients with slowly expanded erythematous plaques and patches. This will help protect the patient from other important diabetic microangiopathic complications, such as nepropathy and retinopathy and also malignant progression, such as squamous cell carcinoma.
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- 2021
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9. Evaluation of Patients Who Referred to Emergency Department with Dermatologic Complaints
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Tayfun ÖZTÜRK, Ömer Levent AVŞAROĞULLARI, Murat BORLU, and Bahadır TAŞLIDERE
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emergency department ,dermatology ,complaint ,Medicine - Abstract
Aim:The aim of this study was to give information about demographic and clinical characteristics, consultation, discharge, hospitalization rates and life-threatening clinical presentations of patients presenting to the Emergency Department with dermatological complaints.Materials and Methods:The study prospectively included patients older than 16 who were admitted to Erciyes University Hospital Emergency Department with dermatological complaints between. The evaluated parameters were age, gender, patients history, complaint, complaint onset, the period spent until admission, type of lesion, diagnosis, consultations, hospitalization, and discharge status.Results:A total of 400 patients were included in the study. Patients who presented with dermatological complaints represented %0.70 of all patients admitted to the Emergency Department. 221 (55%) of the patients were female with a mean age of 38.6 years. Skin redness was the most common cause of admission (29.8%) and urticaria was the most common diagnosis (54.3%). 48.3% of the patients applied to the emergency department at least 24 hours after the onset of symptoms. 31% of the patients were consulted. ‘True dermatological emergencies’ such as necrotizing fasciitis, toxic epidermal necrolysis, and erythema multiforme, were diagnosed in only three patients (0.75%). 19% of the patients were hospitalized and the most common diagnosis was cellulitis (30.8%). The body surface area of the lesion alone did not affect the rate of hospitalization.Conclusion:The proportion of patients presenting with dermatological complaints to the Emergency Department is limited. Especially, patients with accompanying life-threatening systemic organ involvement should be hospitalized.
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- 2019
10. Decrease in RNase HII and Accumulation of lncRNAs/DNA Hybrids: A Causal Implication in Psoriasis?
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Ecmel Mehmetbeyoglu, Leila Kianmehr, Murat Borlu, Zeynep Yilmaz, Seyma Basar Kılıc, Hassan Rajabi-Maham, Serpil Taheri, and Minoo Rassoulzadegan
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psoriasis ,non-coding RNAs ,telomere length ,RNA–DNA hybrid ,TERRA ,RNase HII ,Microbiology ,QR1-502 - Abstract
Functional long non-coding RNAs (lncRNAs) have been in the limelight in aging research because short telomeres are associated with higher levels of TERRA (Telomeric Repeat containing RNA). The genomic instability, which leads to short telomeres, is a mechanism observed in cell aging and in a class of cancer cells. Psoriasis, a skin disease, is a disorder of epidermal keratinocytes, with altered telomerase activity. Research on the fraction of nascent RNAs in hybrid with DNA offers avenues for new strategies. Skin and blood samples from patients were fractionated to obtain the RNA associated with DNA as a R-loop structure. The higher amount of TERRA levels attached with each chromosome end was found with psoriasis patients in blood and skin. In addition to telomeric TERRA, we evidenced accumulation of others non-coding RNA, such as non-telomeric TERRA and centromeric transcripts. Increased levels of non-coding RNAs attached to DNA correlates with a decreased in Ribonuclease HII (RNase-HII) transcript which means that overall unresolved DNA–RNA hybrids can ultimately weaken DNA and cause skin lesions. Since the genome is actively transcribed, cellular RNase-HII is essential for removing RNA from the DNA–RNA hybrid in controls of genome stability and epigenome shaping and can be used as a causal prognostic marker in patients with psoriasis.
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- 2022
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11. Differences in skin lesions of endogenous and exogenous Cushing’s patients
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Fatma Erden, Murat Borlu, Yasin Simsek, and Hasan Fahrettin Kelestemur
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cushing’s syndrome ,dermatological findings ,exogenous cushing’s ,endogenous cushing’s ,skin alterations ,Dermatology ,RL1-803 ,Internal medicine ,RC31-1245 - Published
- 2018
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12. Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part one
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F. De Benedetti, J. Anton, M. Gattorno, H. Lachmann, I. Kone-Paut, S. Ozen, J. Frenkel, A. Simon, A. Zeft, E. Ben-Chetrit, H. M. Hoffman, Y. Joubert, K. Lheritier, A. Speziale, J. Guido, Roberta Caorsi, Federica Penco, Alice Grossi, Antonella Insalaco, Maria Alessio, Giovanni Conti, Federico Marchetti, Alberto Tommasini, Silvana Martino, Romina Gallizzi, Annalisa Salis, Francesca Schena, Francesco Caroli, Alberto Martini, Gianluca Damonte, Isabella Ceccherini, Marco Gattorno, Marie-Louise Frémond, Carolina Uggenti, Lien Van Eyck, Isabelle Melki, Darragh Duffy, Vincent Bondet, Yoann Rose, Bénédicte Neven, Yanick Crow, Mathieu P. Rodero, Yvonne Kusche, Johannes Roth, Katarzyna Barczyk-Kahlert, Giovanna Ferrara, Annalisa Chiocchetti, Silvio Polizzi, Josef Vuch, Diego Vozzi, Anna Mondino, Erica Valencic, Serena Pastore, Andrea Taddio, Flavio Faletra, Umberto Dianzani, Ugo Ramenghi, Qing Zhou, Xiaomin Yu, Erkan Demirkaya, Natalie Deuitch, Deborah Stone, Wanxia Tsai, Amanda Ombrello, Tina Romeo, Elaine F. Remmers, JaeJin Chae, Massimo Gadina, Steven Welch, Seza Ozen, Rezan Topaloglu, Mario Abinun, Daniel L. Kastner, Ivona Aksentijevich, Donatella Vairo, Rosalba Monica Ferraro, Giulia Zani, Jessica Galli, Micaela De Simone, Marco Cattalini, Elisa Fazzi, Silvia Giliani, Ebun Omoyinmi, Ariane Standing, Dorota Rowczenio, Annette Keylock, Sonia Melo Gomes, Fiona Price-Kuehne, Sira Nanthapisal, Claire Murphy, Thomas Cullup, Lucy Jenkins, Kimberly Gilmour, Despina Eleftheriou, Helen Lachmann, Philip Hawkins, Nigel Klein, Paul Brogan, Anita Dhanrajani, Mercedes Chan, Stephanie Pau, Janet Ellsworth, Jaime Guzman, Florence A. Aeschlimann, Marinka Twilt, Simon W. Eng, Shehla Sheikh, Ronald M. Laxer, Diane Hebert, Damien Noone, Christian Pagnoux, Susanne M. Benseler, Rae S. Yeung, Christoph Kessel, Katrin Lippitz, Toni Weinhage, Claas Hinze, Helmut Wittkowski, Dirk Holzinger, Niklas Grün, Dirk Föll, Pieter Van Dijkhuizen, Federica Del Chierico, Clara Malattia, Alessandra Russo, Denise Pires Marafon, Nienke M. ter Haar, Silvia Magni-Manzoni, Sebastiaan J. Vastert, Bruno Dallapiccola, Berent Prakken, Fabrizio De Benedetti, Lorenza Putignani, Berna Eren Fidanci, Kenan Barut, Serap Arıcı, Dogan Simsek, Mustafa Cakan, Ezgi D. Batu, Sezgin Şahin, Ayşenur Kısaarslan, Ebru Yilmaz, Özge Basaran, Ferhat Demir, Kubra Ozturk, Zübeyde Gunduz, Betül Sozeri, Balahan Makay, Nuray Ayaz, Onder Yavascan, Ozlem Aydog, Yelda Bilginer, Zelal Ekinci, Dilek Yıldız, Faysal Gök, Muferret Erguven, Erbil Unsal, Ozgur Kasapcopur, For the FMF Arthritis Vasculitis and Orphan Disease Research in Paediatric Rheumatology (FAVOR), Hafize E. Sönmez, Betül Sözeri, Yonatan Butbul, Seza Özen, Claudia Bracaglia, Giusi Prencipe, Manuela Pardeo, Geneviève Lapeyre, Emiliano Marasco, Walter Ferlin, Robert Nelson, Cristina de Min, N. Ruperto, H. I. Brunner, P. Quartier, T. Constantin, E. Alexeeva, K. Marzan, N. Wulffraat, R. Schneider, S. Padeh, V. Chasnyk, C. Wouters, J. B. Kuemmerle-Deschner, T. Kallinich, B. Lauwerys, E. Haddad, E. Nasonov, M. Trachana, O. Vougiouka, K. Leon, E. Vritzali, A. Martini, D. Lovell, PRINTO/PRCSG, Stefano Volpi, Claudia Pastorino, Francesca Kalli, Alessia Omenetti, Sabrina Chiesa, Arinna Bertoni, Paolo Picco, Gilberto Filaci, Elisabetta Traggiai, Marie-Louise Fremond, Naoki Kitabayashi, Olivero Sacco, Isabelle Meyts, Marie-Anne Morren, Carine Wouters, Eric Legius, Isabelle Callebaut, Christine Bodemer, Frederic Rieux-Laucat, Mathieu Rodero, Nadia Jeremiah, Alexandre Belot, Eric Jeziorski, Didier Bessis, Guilhem Cros, Gillian I. Rice, Bruno Charbit, Anne Hulin, Nihel Khoudour, Consuelo Modesto Caballero, Monique Fabre, Laureline Berteloot, Muriel Le Bourgeois, Philippe Reix, Thierry Walzer, Despina Moshous, Stéphane Blanche, Alain Fischer, Brigitte Bader-Meunier, Frédéric Rieux-Laucat, K. Annink, N. ter Haar, S. Al-Mayouf, G. Amaryan, K. Barron, S. Benseler, P. Brogan, L. Cantarini, M. Cattalini, A. Cochino, F. Dedeoglu, A. De Jesus, O. Dellacasa, E. Demirkaya, P. Dolezalova, K. Durrant, G. Fabio, R. Gallizzi, R. Goldbach-Mansky, E. Hachulla, V. Hentgen, T. Herlin, M. Hofer, H. Hoffman, A. Insalaco, A. Jansson, I. Koné-Paut, A. Kozlova, J. Kuemmerle-Deschner, R. Laxer, S. Nielsen, I. Nikishina, A. Ombrello, E. Papadopoulou-Alataki, A. Ravelli, D. Rigante, R. Russo, Y. Uziel, Nienke ter Haar, Jerold Jeyaratnam, Anna Simon, Matteo Doglio, Jordi Anton, Consuelo Modesto, Pierre Quartier, Esther Hoppenreijs, Luca Cantarini, Loredana Lepore, Inmaculada Calvo Penades, Christina Boros, Rita Consolini, Donato Rigante, Ricardo Russo, Jana Pachlopnik Schmid, Thirusha Lane, Nicolino Ruperto, Joost Frenkel, Chiara Passarelli, Elisa Pisaneschi, Virginia Messia, Antonio Novelli, Fabrizio Debenedetti, P. A. Brogan, X. Wei, Martina Finetti, Francesca Orlando, Elisabetta Cortis, Angela Miniaci, Nicola Ruperto, Charlotte Eijkelboom, Pavla Dolezalova, Isabelle Koné-Paut, Marija Jelusic-Drazic, Liliana Bezrodnik, Mari Carmen Pinedo, Valda Stanevicha, Marielle van Gijn, Silvia Federici, Hermann Girschick, Gerd Ganser, Susan Nielsen, Troels Herlin, Sulaiman Mohammed Al-Mayouf, Michael Hofer, Jasmin Kuemmerle-Deschner, Susanne Schalm, Annette Jansson, on behalf of PRINTO and Eurofever registry, Marta Marchi, Chiara Marini, Angelo Ravelli, Alberto Garaventa, Sonia Carta, Enrica Balza, Patrizia Castellani, Caterina Pellecchia, Silvia Borghini, Maria Libera Trotta, Anna Rubartelli, Andrew Henrey, Thomas Loughin, Roberta Berard, Natalie Shiff, Roman Jurencak, Susanne Benseler, Lori Tucker, on behalf of ReACCh-Out Investigators, Charalampia Papadopoulou, Ying Hong, Petra Krol, Yiannis Ioannou, Clarissa Pilkington, Hema Chaplin, Stephania Simou, Marietta Charakida, Lucy Wedderburn, Lynn R. Spiegel, Sara Ahola Kohut, Jennifer Stinson, Paula Forgeron, Miriam Kaufman, Nadia Luca, Khush Amaria, Mary Bell, J Swart, F. Boris, E. Castagnola, A. Groll, G. Giancane, G. Horneff, H. I. Huppertz, T. Wolfs, E. Alekseeva, V. Panaviene, F. Uettwiller, V. Stanevicha, L. M. Ailioaie, E. Tsitami, S. Kamphuis, G. Susic, F. Sztajnbok, B. Flato, A. Pistorio, Stephanie J. W. Shoop, Suzanne M. M. Verstappen, Janet E. McDonagh, Wendy Thomson, Kimme L. Hyrich, CAPS, Maarit Tarkiainen, Pirjo Tynjala, Pekka Lahdenne, Janne Martikainen, Acute-JIA Study Group, Meredyth Wilkinson, Christopher Piper, Georg Otto, Claire T. Deakin, Stefanie Dowle, Stefania Simou, Daniel Kelberman, Claudia Mauri, Elizabeth Jury, David Isenberg, Lucy R. Wedderburn, Kiran Nistala, I. Foeldvari, D. J. Lovell, G. Simonini, M. Bereswill, J. Kalabic, Kiem Oen, Brian M. Feldman, Brenden Dufault, Jennifer Lee, Karen Watanabe Duffy, Ciaran Duffy, ReACCh-Out Investigators, N. Tzaribachev, G. Vega-Cornejo, I. Louw, A. Berman, I. Calvo, R. Cuttica, F. Avila-Zapata, R. Cimaz, E. Solau-Gervais, R. Joos, G. Espada, X. Li, M. Nys, R. Wong, S. Banerjee, For Pediatric Rheumatology International Trials Organization (PRINTO)/Pediatric Rheumatology Collaborative Study Group (PRCSG), Rebecca Nicolai, Margherita Verardo, Adele D’Amico, Luisa Bracci-Laudiero, Gian Marco Moneta, Gillian Rice, Anne-Laure Mathieu, Sulliman O. Omarjee, Tracy A. Briggs, James O’Sullivan, Simon Williams, Rolando Cimaz, Eve Smith, Michael W. Beresford, Yanick J. Crow, GENIAL Investigators, UK JSLE Study Group, Madeleine Rooney, Nick Bishop, joyce davidson, Clarissa pilkington, Michael Beresford, Jacqui Clinch, Rangaraj Satyapal, Helen Foster, Janet Gardner Medwin, Janet McDonagh, Sue Wyatt, On Behalf of the British Society for Paediatric and Adolescent Rheumatology, Valentina Litta Modignani, Francesco Baldo, Stefano Lanni, Alessandro Consolaro, Giovanni Filocamo, Helen J. Lachmann, on behalf of Eurofever Registry, Gianmarco Moneta, Camilla Celani, Bilade Cherqaoui, Linda Rossi-Semerano, Perrine Dusser, Véronique Hentgen, Claire Grimwood, Linda Rossi, Isabelle Kone Paut, Veronique Hentgen, Denise Lasigliè, Denise Ferrera, Giulia Amico, Marco Di Duca, Laura Obici, Roberto Ravazzolo, Ryuta Nishikomori, Juan Arostegui, Andrea Petretto, Chiara Lavarello, Elvira Inglese, Federica Vanoni, Michaël Hofer, on behalf of EUROFEVER PROJECT, P. N. Hawkins, T. van der Poll, U. A. Walker, H. H. Tilson, Pascal N. Tyrrell, Raphaela Goldbach-Mansky, Norbert Blank, Hal M. Hoffman, Elisabeth Weissbarth-Riedel, Boris Huegle, Tilmann Kallinich, Ahmet Gul, Marlen Oswald, Fatma Dedeoglu, Aki Hanaya, Takako Miyamae, Manabu Kawamoto, Yumi Tani, Takuma Hara, Yasushi Kawaguchi, Satoru Nagata, Hisashi Yamanaka, Almira Ćosićkić, Fahrija Skokić, Belkisa Čolić, Sanimir Suljendić, Anna Kozlova, Irina Mersiyanova, Mariya Panina, Lily Hachtryan, Vasiliy Burlakov, Elena Raikina, Alexey Maschan, Anna Shcherbina, Banu Acar, Meryem Albayrak, Betul Sozeri, Sezgin Sahin, Amra Adrovic, Nese Inan, Serhan Sevgi, Caroline M. Andreasen, Anne Grethe Jurik, Mia B. Glerup, Christian Høst, Birgitte T. Mahler, Ellen-Margrethe Hauge, Cecilia Lazea, Laura Damian, Calin Lazar, Rodica Manasia, Chloe M. Stephenson, Vimal Prajapati, Paivi M. Miettunen, Dilek Yılmaz, Yavuz Tokgöz, Yasin Bulut, Harun Çakmak, Ferah Sönmez, Elif Comak, Gülşah Kaya Aksoy, Mustafa Koyun, Sema Akman, Yunus Arıkan, Ender Terzioğlu, Osman Nidai Özdeş, İbrahim Keser, Hüseyin Koçak, Ayşen Bingöl, Aygen Yılmaz, Reha Artan, X. Xu, Fatemeh F. Mehregan, Vahid Ziaee, Mohammad H. Moradinejad, Francesco La Torre, Clotilde Alizzi, Pio D’Adamo, G. Junge, J. Gregson, Hasmik Sargsyan, Hulya Zengin, Berna E. Fidanci, Cagla Kaymakamgil, Dilek Konukbay, Dilek Yildiz, Faysal Gok, Iris Stoler, Judith Freytag, Banu Orak, Christine Seib, Lars Esmann, Eva Seipelt, Faekah Gohar, Dirk Foell, Ismail Dursun, Sebahat Tulpar, Sibel Yel, Demet Kartal, Murat Borlu, Funda Bastug, Hakan Poyrazoglu, Zubeyde Gunduz, Kader Kose, Mehmet E. Yuksel, Abdullah Calıskan, Ahmet B. Cekgeloglu, Ruhan Dusunsel, Katerina Bouchalova, Jana Franova, Marcel Schuller, Marie Macku, Katerina Theodoropoulou, Raffaella Carlomagno, Annette von Scheven-Gête, Claudia Poloni, Laura O. Damian, Dan Cosma, Amanda Radulescu, Dan Vasilescu, Liliana Rogojan, Simona Rednic, Mihaela Lupse, Lien De Somer, Pierre Moens, Rocio Galindo Zavala, Laura Martín Pedraz, Esmeralda Núñez Cuadros, Gisela Díaz-Cordovés Rego, Antonio L. Urda Cardona, Ilaria Dal Forno, Sara Pieropan, Ombretta Viapiana, Davide Gatti, Gloria Dallagiacoma, Paola Caramaschi, Domenico Biasi, Daniel Windschall, Ralf Trauzeddel, Hartwig Lehmann, Rainer Berendes, Maria Haller, Manuela Krumrey-Langkammerer, Antje Nimtz-Talaska, Philipp Schoof, Ralf Felix Trauzeddel, Christine Nirschl, Estefania Quesada-Masachs, Carla Aguilar Blancafort, Sara Marsal Barril, Francisca Aguiar, Rita Fonseca, Duarte Alves, Ana Vieira, Alberto Vieira, Jorge A. Dias, Iva Brito, Gordana Susic, Vera Milic, Goran Radunovic, Ivan Boricic, Pauline Marteau, Catherine Adamsbaum, Michel De Bandt, Irène Lemelle, Chantal Deslandre, Tu Anh Tran, Anne Lohse, Elisabeth Solau-Gervais, Pascal Pillet, Julien Wipff, Cécile Gaujoux-Viala, Sylvain Breton, Valérie Devauchelle-Pensec, Sandra Gran, Olesja Fehler, Stefanie Zenker, Michael Schäfers, Thomas Vogl, Severine Guillaume Czitrom, EH Pieter Van Dijkhuizen, Silvia Magni Manzoni, Francesca Magnaguagno, Laura Tanturri de Horatio, Nienke M. Ter Haar, Annemieke S. Littooij, Vitor A. Teixeira, Raquel Campanilho-Marques, Ana F. Mourão, Filipa O. Ramos, Manuela Costa, Wafa A. Madan, Orla G. Killeen, Adriana Rodriguez Vidal, Diana Sueiro Delgado, Maria Isabel Gonzalez Fernandez, Berta Lopez Montesinos, Aleksey Kozhevnikov, Nina Pozdeeva, Mikhail Konev, Evgeniy Melchenko, Vladimir Kenis, Gennadiy Novik, Aysenur Pac Kısaarslan, Butsabong Lerkvaleekul, Suphaneewan Jaovisidha, Witaya Sungkarat, Niyata Chitrapazt, Praman Fuangfa, Thumanoon Ruangchaijatuporn, Soamarat Vilaiyuk, Dan Ø. Pradsgaard, Arne Hørlyck, Anne H. Spannow, Carsten W. Heuck, Talia Diaz, Fernando Garcia, Lorenia De La Cruz, Nadina Rubio, Joanna Świdrowska-Jaros, Elzbieta Smolewska, Mirta Lamot, Lovro Lamot, Mandica Vidovic, Edi Paleka Bosak, Ivana Rados, Miroslav Harjacek, Nikolay Tzaribachev, Polymnia Louka, Romiesa Hagoug, Chiara Trentin, Olga Kubassova, Mark Hinton, Mikael Boesen, Olena A. Oshlianska, Illya A. Chaikovsky, G. Mjasnikov, A. Kazmirchyk, Umberto Garagiola, Irene Borzani, Paolo Cressoni, Fabrizia Corona, Eszter Dzsida, Giampietro Farronato, Antonella Petaccia, Alenka Gagro, Agneza Marija Pasini, Goran Roic, Ozren Vrdoljak, Lucija Lujic, Matija Zutelija-Fattorini, Monika M. Esser, Deepthi R. Abraham, Craig Kinnear, Glenda Durrheim, Mike Urban, Eileen Hoal, Victoria B. Nikolayenko, Kubilay Şahin, Yasar Karaaslan, Adele Civino, Giovanni Alighieri, Sergio Davì, Roberto Rondelli, Andrea Magnolato, Francesca Ricci, Alma Olivieri, Valeria Gerloni, Bianca Lattanzi, Francesca Soscia, Alessandro De Fanti, Stefania Citiso, Lorenzo Quartulli, Maria Cristina Maggio, Manuela Marsili, Maria Antonietta Pelagatti, Valentino Conter, Franca Fagioli, Andrea Pession, Marco Garrone, Mariangela Rinaldi, Jaime De Inocencio, Stella Garay, Daniel J. Lovell, Berit Flato, EPOCA Study Group, Angela Aquilani, Simona Cascioli, Ivan Caiello, Denise Pires-Marafón, Rita Carsetti, Emily Robinson, Salvatore Albani, Wilco de Jager, Sytze de Roock, Trang Duong, Justine Ellis, Kimme Hyrich, Laetitia Jervis, Daniel Lovell, Lucy Marshall, Elizabeth D. Mellins, Kirsten Minden, Jane Munro, Peter A. Nigrovic, Jason Palman, Sunil Sampath, Laura E. Schanberg, Susan D. Thompson, Richard Vesely, Chris Wallace, Chris Williams, Qiong Wu, Nico Wulffraat, Rae S. M. Yeung, M. B. Seyger, D. Arikan, J. K. Anderson, A. Lazar, D. A. Williams, C. Wang, R. Tarzynski-Potempa, J. S. Hymans, Gabriele Simonini, Erika Scoccimarro, Irene Pontikaki, Teresa Giani, Alessandro Ventura, Pier Luigi Meroni, Gaetana Minnone, Marzia Soligo, Luigi Manni, Luisa Bracci Laudiero, Noortje Groot, I. Grein, N. M. Wulffraat, R. Schepp, G. Berbers, C. C. Barbosa Sandoval de Souza, V. Paes Leme Ferriani, G. Pileggi, S. de Roock, Ingrid H. R. Grein, Silvia Scala, Elisa Patrone, Casper Schoemaker, on behalf of Dutch JIA patient organization, Wendy Costello, on behalf of ENCA, Suzanne Parsons, Jean-David Cohen, Damien Bentayou, Marc-Antoine Bernard Brunel, Sonia Trope, Jens Klotsche, Miriam Listing, Martina Niewerth, Gerd Horneff, Angelika Thon, Hans-Iko Huppertz, Kirsten Mönkemöller, Ivan Foeldvari, ICON study group, Achille Marino, Stefano Stagi, Niccolò Carli, Federico Bertini, Adriana S. Díaz-Maldonado, Sally Pino, Pilar Guarnizo, Alfonso Ragnar Torres-Jimenez, Berenice Sanchez-Jara, Eunice Solis-Vallejo, Adriana Ivonne Cespedes-Cruz, Maritza Zeferino-Cruz, Julia Veronica Ramirez-Miramontes, Ankur Kumar, Anju Gupta, Deepti Suri, Amit Rawat, Nandita Kakkar, Surjit Singh, Özge A. Gücenmez, Erbil Ünsal, Bo Magnusson, Karina Mördrup, Anna Vermé, Christina Peterson, Board of the Swedish Pediatric Rheumatology Registry, Caroline Freychet, Jean Louis Stephan, Cathryn E. Harkness, Leanne Foster, Emma Henry, Pauline Taggart, Coskun F. Ozkececi, Esra Kurt, Gokalp Basbozkurt, Daiva Gorczyca, Jacek Postępski, Aleksandra Czajkowska, Bogumiła Szponar, Mariola Paściak, Anna Gruenpeter, Iwona Lachór-Motyka, Daria Augustyniak, Edyta Olesińska, Emediong S. Asuka, Tatyana Golovko, Samuel U. Aliejim, Emilio Inarejos Clemente, Estibaliz Iglesias Jimenez, Joan Calzada Hernandez, Sergi Borlan Fernandez, Clara Gimenez Roca, David Moreno Romo, Natalia Rodriguez Nieva, Juan Manuel Mosquera Angarita, Jordi Anton Lopez, Esmeralda Nuñez-Cuadros, Gisela Diaz-Cordovés, Rocío Galindo-Zavala, Antonio Urda-Cardona, Antonio Fernández-Nebro, Daniel Álvarez de la Sierra, Marina Garcia Prat, Mónica Martínez Gallo, Ricardo Pujol Borrell, Ana M. Marín Sánchez, Etienne Merlin, Sylvie Fraitag, Jean-Louis Stephan, Federico Annoni, Giancarla Di Landro, Sofia Torreggiani, Marta Torcoletti, Georgina Tiller, Jo Buckle, Angela Cox, Peter Gowdie, Roger C. Allen, Jonathan D. Akikusa, Hayde G. Hernández-Huirache, Edel R. Rodea-Montero, William Fahy, Christelle Sordet, Karin B. Berggren, Johanna T. Kembe, Joyce Bos, Wineke Armbrust, Marco van Brussel, Jeanette Cappon, Pieter Dijkstra, Jan Geertzen, Elizabeth Legger, Marion van Rossum, Pieter Sauer, Otto Lelieveld, Levent Buluc, Gur Akansel, Bahar Muezzinoglu, Ljubov Rychkova, Tatyana Knyazeva, Anna Pogodina, Tatyana Belova, Tamara Mandzyak, Ekaterina Kulesh, Alessandro Cafarotti, Cosimo Giannini, Roberta Salvatore, Giuseppe Lapergola, Caterina Di Battista, Maria Loredana Marcovecchio, Raffaella Basilico, Piernicola Pelliccia, Francesco Chiarelli, Luciana Breda, Beverley Almeida, Sarah Tansley, Harsha Gunawardena, Neil McHugh, Juvenile Dermatomyositis Research Group (JDRG), Jessie Aouizerate, Marie De Antonio, Christine Barnerias, Guillaume Bassez, Isabelle Desguerre, Romain Gherardi, Jean-Luc Charuel, François-Jérôme Authier, Cyril Gitiaux, C. H. Spencer, Rabheh Abdul Aziz, Chack-Yung Yu, Brent Adler, Sharon Bout-Tabaku, Katherine Lintner, Melissa Moore-Clingenpeel, Liza McCann, Nicola Ambrose, Mario Cortina-Borja, Juvenile Dermatomyositis Cohort and Biomarker Study (JCDBS), Prasad T. Oommen, Fabian Speth, Johannes-Peter Haas, Working Group “Juvenile Dermatomyositis” of the German Society for Paediatric and Adolescent Rheumatology (GKJR), Claudio Lavarello, Gabriella Giancane, Angela Pistorio, Lisa Rider, Rohit Aggarwal, Sheila K. Oliveira, Ruben Cuttica, Michel Fischbach, Gary Sterba, Karine Brochard, Frank Dressler, Patrizia Barone, Ruben Burgos-Vargas, Elizabeth Candell Chalom, Marine Desjonqueres, Graciela Espada, Anders Fasth, Stella Maris Garay, Rose-Marie Herbigneaux, Claire Hoyoux, Chantal Job Deslandre, Frederick W. Miller, Jiri Vencovsky, Erdal Sag, Gulsev Kale, Haluk Topaloglu, Beril Talim, Francesco Zulian, Tadej Avcin, Roberto Marini, Anne Pagnier, Michel Rodiere, Christine Soler, Rebecca Ten Cate, Yosef Uziel, Jelena Vojinovic, Ana V. Villarreal, Nydia Acevedo, Yuridiana Ramirez, Enrique Faugier, Rocio Maldonado, Bita Arabshahi, John H. Lee, Ian Leibowitz, Lawrence O. Okong’o, Jo Wilmshurst, Monika Esser, Christiaan Scott, Ezgi Deniz Batu, Nagehan Emiroglu, Hafize Emine Sonmez, Gokcen Dilsa Tugcu, Zehra Serap Arici, Ebru Yalcin, Deniz Dogru, Ugur Ozcelik, Mithat Haliloglu, Nural Kiper, Masato Yashiro, Mutsuko Yamada, Toshihiko Yabuuchi, Tomonobu Kikkawa, Nobuyuki Nosaka, Yosuke Fujii, Yukie Saito, Hirokazu Tsukahara, Sulaiman M. Al-Mayouf, Nora AlMutiari, Mohammed Muzaffer, Rawiah shehata, Adel Al-Wahadneh, Reem Abdwani, Safia Al-Abrawi, Mohammed Abu-shukair, Zeyad El-Habahbeh, Abdullah Alsonbul, Aleksandra Szabat, Monika Chęć, Violetta Opoka-Winiarska, Biman Saikia, Ranjana W. Minz, Christine Arango, Clara Malagon, Maria D. P. Gomez, Angela C. Mosquera, Ricardo Yepez, Tatiana Gonzalez, Camilo Vargas, GRIP study group, Marta Balzarin, Biagio Castaldi, Elena Reffo, Francesca Sperotto, Giorgia Martini, Alessandra Meneghel, Ornella Milanesi, Ozgur Kasapçopur, Maria Teresa Terreri, Ekaterina Alexeeva, Maria Katsicas, Mikhail Kostik, Thomas Lehman, W.-Alberto Sifuentes-Giraldo, Vanessa Smith, Flavio Sztajnbok, Tadey Avcin, Maria Jose Santos, Dana Nemcova, Cristina Battagliotti, Liora Harel, Mahesh Janarthanan, Kathryn Torok, Nicola Helmus, Eileen Baildem, Michael Blakley, Kim Fligelstone, Antonia Kienast, Clare Pain, Amanda Saracino, Gabriele Simoni, Lisa Weibel, Maria K. Osminina, Nathalia A. Geppe, Olga V. Niconorova, Olesya V. Karashtina, Oksana V. Abbyasova, Olga V. Shpitonkova, Sinem Durmus, Hafize Uzun, Angela Mauro, Eleonora Fanti, Fabio Voller, Franca Rusconi, Fernando Garcia-Rodriguez, Ana V. Villarreal-Treviño, Angel J. Flores-Pineda, Paola B. Lara-Herrea, Diego R. Salinas-Encinas, Talia Diaz-Prieto, Maria R. Maldonado-Velazquez, Sarbelio Moreno-Espinosa, Enrique Faugier-Fuentes, Mirella Crapanzano, Ilaria Parissenti, Man S. Parihar, Pandiarajan Vignesh, ManojKumar Rohit, Kavitha Gopalan, Savita V. Attri, Alan Salama, David Jayne, Mark Little, Yulia Kostina, Galina Lyskina, Olga Shpitonkova, Alena Torbyak, Olga Shirinsky, Maria Francesca Gicchino, Maria Cristina Smaldone, Mario Diplomatico, Alma Nunzia Olivieri, C H. Spencer, Richard McClead, Hiren Patel, Chung-Yung Yu, Dita Cebecauerová, Tomáš Dallos, Edita Kabíčková, Martin Kynčl, Daniela Chroustová, Jozef Hoza, Dana Němcová, Vladimír Tesař, Pavla Doležalová, Tuncay Hazirolan, Fatih Ozaltin, Fabiola Almeida, Isabela H. Faria de Paula, Maíra M. Sampaio, Fernando N. Arita, Andressa G. Alves, Maria Carolina Santos, Eunice M. Okuda, Silvana B. Sacchetti, Fernanda Falcini, Marini Francesca, Gemma Lepri, Marco Matucci-Cerinic, Maria Luisa Brandi, Hakan Kisaoglu, Sema Misir, Selim Demir, Yuksel Aliyazicioglu, Mukaddes Kalyoncu, Carlos Eduardo Ramalho, Fabiola D. Almeida, Joan Calzada-Hernández, Rosa Bou, Estíbaliz Iglesias, Judith Sánchez-Manubens, Fredy Hermógenes Prada Martínez, Clara Giménez Roca, Sergi Borlan Fernández, Marek Bohm, Kamran Mahmood, Valentina Leone, Mark Wood, Ken-Ichi Yamaguchi, Satoshi Fujikawa, Working Group of Behçet’s Disease, Pediatric Rheumatology Association of Japan (PRAJ), Kyu Yeun Kim, Do Young Kim, Dong Soo Kim, Maka Ioseliani, Ivane Chkhaidze, Maia Lekishvili, Nana Tskhakaia, Shorena Tvalabeishvili, Aleksandre Kajrishvili, Maiko Takakura, Masaki Shimizu, Natsumi Inoue, Mao Mizuta, Akihiro Yachie, Giovanni Corsello, Maryam Piram, Carla Maldini, Sandra Biscardi, Nathalie Desuremain, Catherine Orzechowski, Emilie Georget, Delphine Regnard, Isabelle Kone-Paut, Alfred Mahr, Mihaela Sparchez, Zeno Sparchez, Nydia Acevedo Silva, Ana V. Villarreal Treviño, Yuridiana Ramirez Loyola, Talia Diaz Prieto, Enrique Faugier Fuentes, Maria D. R. Maldonado Velazquez, Pilar Perez, Sagar Bhattad, Ranjana Minz, Jitendra Shandilya, Pediatric Allergy and Immunology Unit, PGIMER, Chandigarh, Ana Villarreal, Yuridiana Ramírez, Zeynep Birsin Özçakar, Suat Fitoz, Fatos Yalcinkaya, Annacarin Horne, Francesca Minoia, Francesca Bovis, Sergio Davi, Priyankar Pal, Kimo Stein, Sandra Enciso, Michael Jeng, Despoina Maritsi, Randy C. Cron, Anne Thorwarth, Sae Lim von Stuckrad, Angela Rösen-Wolff, Hella Luksch, Patrick Hundsdoerfer, Peter Krawitz, Nuray Aktay Ayaz, Doğan Simsek, Şebnem Sara Kılıc, Emine Sonmez, Aysenur Pac Kisaarslan, Ozge Altug Gucenmez, Z. Serap Arıcı, Fatih Kelesoglu, Zelal Ekinci Ekinci, Maria Miranda-Garcia, Carolin Pretzer, Michael Frosch, F. Gohar, Angela McArdle, Niamh Callan, Belinda Hernandez, Miha Lavric, Oliver FitzGerald, Stephen R. Pennington, Joachim Peitz, Joern Kekow, Ariane Klein, Anna C. Schulz, Frank Weller-Heinemann, Anton Hospach, J-Peter Haas, BIKER collaborative group, Karen Put, Jessica Vandenhaute, Anneleen Avau, Annemarie van Nieuwenhuijze, Ellen Brisse, Tim Dierckx, Omer Rutgeerts, Josselyn E. Garcia-Perez, Jaan Toelen, Mark Waer, Georges Leclercq, An Goris, Johan Van Weyenbergh, Adrian Liston, Patrick Matthys, Carine H. Wouters, Yasuo Nakagishi, Michael J. Ombrello, Victoria Arthur, Anne Hinks, Patricia Woo, International Childhood Arthritis Genetics (INCHARGE) Consortium, Barbara Stanimirovic, Biljana Djurdjevic-Banjac, Olivera Ljuboja, Boris Hugle, MArgarita Onoufriou, Olga Vougiouka, Kenza Bouayed, Sanae El Hani, Imane Hafid, Nabiha Mikou, Nunu Shelia, Mari Laan, Jaanika Ilisson, and Chris Pruunsild
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Pediatrics ,RJ1-570 ,Diseases of the musculoskeletal system ,RC925-935 - Published
- 2017
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13. Effects of isotretinoin on the olfactory function in patients with acne
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Demet Kartal, Mehmet Yaşar, Levent Kartal, Ibrahim Özcan, and Murat Borlu
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Isotretinoin ,Olfaction disorders ,Smell ,Dermatology ,RL1-803 - Abstract
Abstract: Background: Isotretinoin is a synthetic analog of vitamin A. Recent studies support a role for retinoic acid in the recovery of olfactory function following injury in mice. Objective: This study aimed at determining the effect of isotretinoin on olfactory function in patients who have acne and are otherwise healthy. Methods: Forty-five patients (aged 25-40 years) with acne were included in the study. All patients underwent a rhinological examination. Olfactory function was assessed by the Sniffin' Sticks Test. The test was assessed at baseline and in the third month of isotretinoin treatment. Results: Isotretinoin improved the performance of patients in the olfactory test. The SST score increased from 8.7±1.09 to 9.5±1.19 (p
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- 2017
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14. Skin findings of geriatric patients in Turkey: A 5-year survey
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Demet Kartal, Salih L. Çınar, Sibel Akın, Ayten Ferahbaş, and Murat Borlu
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elderly ,skin findings ,Turkish ,Dermatology ,RL1-803 - Abstract
Background: “Geriatric patients” are a special group among dermatology patients because of the higher incidences of dermatologic and systemic diseases in this group. We aimed to determine the prevalence of dermatologic diseases, their relationship with age/sex, and hospitalization diagnoses with average times of hospitalization in the aged population. Methods: A total 7412 patients aged > 65 years who were admitted to dermatology clinics between April 2009 and April 2014 were included in this analysis. Hospital databases were used for data collection. The data were analyzed according to age, sex, hospitalization rate, and average hospitalization time. Results: Of the total 7412 geriatric patients enrolled in this study, 3640 (49.1%) were male and 3772 (50.9%) female. The two most frequent dermatologic diseases were eczematous dermatitis (32.2%) and skin infections and infestations (18.5%). In females, bullous diseases were more common, whereas in males, skin infections and infestations were more common (p 0.05). Conclusion: Eczematous dermatitis is the most common dermatologic disease in the elderly. Both treatment resistance and difficulty in differential diagnoses make eczematous dermatitis and pruritus the two most frequent reasons for hospitalization. Additionally, dividing patients into subgroups according to age has no relevance to dermatological practice.
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- 2015
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15. Case Report: A rare cause of oral bullae: Angina bullosa hemorrhagica [version 1; referees: 2 approved]
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Salih Levent Cinar, Demet Kartal, Özlem Canöz, Murat Borlu, and Ayten Ferahbas
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Acquired & Inherited Bullous Disorders ,Medicine ,Science - Abstract
Angina bullosa hemorrhagica (ABH) is a benign disorder of the oral cavity. Clinically, oral, blood-filled blisters are seen. To give a proper diagnosis, one should rule out any other cause. We aim to present this case in order to emphasize this rare cause of oral bullae which is necessary to be differentiated from many serious dermatological and hematological disorders.
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- 2017
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16. Thyroid abnormalities in paediatric patients with vitiligo: retrospective study
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Demet Kartal, Murat Borlu, Salih Levent Çınar, Ayten Kesikoğlu, and Serap Utaş
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vitiligo ,thyroid abnormalities ,Dermatology ,RL1-803 ,Internal medicine ,RC31-1245 - Abstract
Introduction : The association between vitiligo and thyroid disease is not fully investigated especially in paediatric patients. Aim : To determine the incidence of vitiligo and thyroid disorders in children. This is the first report from middle Anatolia and the second report from Turkey. Material and methods : A retrospective chart review was performed to examine the presence of thyroid abnormalities in paediatric patients who had been admitted to the dermatology department with vitiligo. Results : A total of 155 paediatric patients, including 80 (52%) male and 75 (48%) female patients were included. The mean age was 8.6 years. Non segmental vitiligo was the most common type of the disease in 140 (90%) reviewed patients, while segmental vitiligo appeared only in 15 (10%) patients. The mean onset of vitiligo was 5.6 ±0.9 years. A family history of vitiligo was found in 14 (9%) children. Thirty-four (22%) patients had thyroid function tests and/or thyroid autoantibody abnormality. All of these patients had non segmental vitiligo. It was statistically significant (p < 0.05) in types of vitiligo and thyroid disease parameters. Conclusions : Our results show that it may be useful to screen thyroid in children with non segmental vitiligo.
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- 2016
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17. Cutaneous reactions after <scp>COVID</scp> ‐19 vaccination in Turkey: A multicenter study
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Filiz Cebeci Kahraman, Sevil Savaş Erdoğan, Nurhan Döner Aktaş, Hülya Albayrak, Dursun Türkmen, Murat Borlu, Deniz Aksu Arıca, Abdullah Demirbaş, Atiye Akbayrak, Algün Polat Ekinci, Gözde Emel Gökçek, Hilal Ayvaz Çelik, Mustafa Kaan Taşolar, İsa An, Selami Aykut Temiz, Emel Hazinedar, Erhan Ayhan, Pelin Hızlı, Eda Öksüm Solak, Arzu Kılıç, and Ertan Yılmaz
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Dermatology - Abstract
© 2022 Wiley Periodicals LLC.Objectives: In this study covering all of Turkey, we aimed to define cutaneous and systemic adverse reactions in our patient population after COVID-19 vaccination with the Sinovac/CoronaVac (inactivated SARS-CoV-2) and Pfizer/BioNTech (BNT162b2) vaccines. Methods: This prospective, cross-sectional study included individuals presenting to the dermatology or emergency outpatient clinics of a total of 19 centers after having been vaccinated with the COVID-19 vaccines. Systemic, local injection site, and non-local cutaneous reactions after vaccination were identified, and their rates were determined. Results: Of the 2290 individuals vaccinated between April 15 and July 15, 2021, 2097 (91.6%) received the CoronaVac vaccine and 183 (8%) BioNTech. Systemic reactions were observed at a rate of 31.0% after the first CoronaVac dose, 31.1% after the second CoronaVac dose, 46.4% after the first BioNTech dose, and 46.2% after the second BioNTech dose. Local injection site reactions were detected at a rate of 35.6% after the first CoronaVac dose, 35.7% after the second CoronaVac dose, 86.9% after the first BioNTech dose, and 94.1% after the second BioNTech dose. A total of 133 non-local cutaneous reactions were identified after the CoronaVac vaccine (2.9% after the first dose and 3.5% after the second dose), with the most common being urticaria/angioedema, pityriasis rosea, herpes zoster, and maculopapular rash. After BioNTech, 39 non-local cutaneous reactions were observed to have developed (24.8% after the first dose and 5% after the second dose), and the most common were herpes zoster, delayed large local reaction, pityriasis rosea, and urticaria/angioedema in order of frequency. Existing autoimmune diseases were triggered in 2.1% of the patients vaccinated with CoronaVac and 8.2% of those vaccinated with BioNTech. Conclusions: There are no comprehensive data on cutaneous adverse reactions specific to the CoronaVac vaccine. We determined the frequency of adverse reactions from the dermatologist's point of view after CoronaVac and BioNTech vaccination and identified a wide spectrum of non-local cutaneous reactions. Our data show that CoronaVac is associated with less harmful reactions while BioNTech may result in more serious reactions, such as herpes zoster, anaphylaxis, and triggering of autoimmunity. However, most of these reactions were self-limiting or required little therapeutic intervention.
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- 2022
18. Markers of psoriatic skin phenotype: androgen/estrogen and cortisone/cortisol imbalance, and DNA damage
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Şeyma Başar Kılıç, Serpil Taheri, Ecmel Mehmetbeyoğlu, Eda Öksüm Solak, Minoo Rassoulzadegan, and Murat Borlu
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Patients prone to psoriasis suffer after a breakdown of the epidermal barrier and develop poorly healing lesions with abnormal proliferation of keratinocytes.Strong inflammatory reactions with genotoxicity (short telomeres) suggest impaired immune defences with DNA damage repair response (DDR) in patients with psoriasis. Recent evidence indicates the existence of crosstalk mechanisms linking the DDR machinery and hormonal signalling pathways that cooperate to influence both progressions of many diseases and responses to treatment.The aim of this study was to clarify whether steroid biosynthesis and genomic stability markers are altered in parallel during the formation of psoriatic skin. Understanding between the interaction of the steroid pathway and DNA damage response is crucial to addressing underlying fundamental issues and managing resulting epidermal barrier disruption in psoriasis.Twenty patients with psoriasis and fifteen healthy volunteers were included in this study. Transcription levels of estrogen (ESR1, ESR2), androgen (AR), glucocorticoid/mineralocorticoid receptors (NR3C1, NR3C2),HSD11B1/HSD11B2genes, and DNA damage sensors (SMC1A, TREX1, TREX2, SSBP3, RAD1, RAD18, EXO1, POLH, HUS1) were determined by Real-Time-PCR in blood and skin samples (Lesional, non-lesional) from psoriasis and control groups.ResultsWe found thatESR1, ESR2, HSD11B1, NR3C1, NR3C2, POLH, andSMC1Atranscripts were significantly decreased andAR, TREX1, RAD1, andSSBP3transcripts were increased dramatically in the lesional skin compared to skin samples of controls.As a result, we found that the regulation of the steroidogenic pathway was disrupted in the lesional tissue of psoriasis patients and that a sufficient glucocorticoid and mineralocorticoid response did not form and the estrogen/androgen balance was altered in favour of androgens. We suggest that an increased androgen response in the presence of DDR increases the risk of developing psoriasis. Although this situation may be the cause or the consequence of a disruption of the epidermal barrier, our data suggest developing new therapeutic strategies.
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- 2022
19. The Turkish Guideline for the Diagnosis and Management of Hydradenitis Suppurativa
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Murat Borlu, Nilgün Atakan, Emel Bülbül Başkan, Fatma Figen Özgür, Beyza Özçinar, Burhan Engin, Erkan Alpsoy, and Metin Çakmakçi
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Dermatology - Published
- 2021
20. Accurate Segmentation of Dermoscopic Images by Image Thresholding Based on Type-2 Fuzzy Logic.
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M. Emin Yüksel and Murat Borlu
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- 2009
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21. Recommendations on the use of systemic treatments for urticaria and atopic dermatitis during the COVID-19 pandemic: Statement of Dermatoallergy Working Group of the Turkish Society of Dermatology
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Hayriye Sarıcaoğlu, Serap Utaş, Ülker Gül, Emel Bülbül Başkan, Teoman Erdem, Zerrin Ogretmen, Sibel Alper, Oktay Taşkapan, Yasemin Erdem, Andac Salman, Rafet Koca, Filiz Canpolat, Özlem Su Küçük, Esen Özkaya, Emek Kocatürk, Nilgün Atakan, Murat Borlu, Ekin Şavk, Selda Pelin Kartal, Alper, Sibel, Göncü, Özgür Emek Kocatürk (ORCID 0000-0003-2801-0959 & YÖK ID 217219), Salman, Andaç, Atakan, Nilgün, Başkan, Emel Bülbül, Borlu, Murat, Canpolat, Filiz, Erdem, Teoman, Erdem, Yasemin, Gül, Ülker, Kartal, Selda Pelin, Koca, Rafet, Küçük, Özlem Su, Öğretmen, Zerrin, Özkaya, Esen, Sarıcaoğlu, Hayriye, Savk, Ekin, Taşkapan, Oktay, Utas, Serap, School of Medicine, and KÜÇÜK, Özlem Su
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medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Statement (logic) ,Turkish ,lcsh:RC870-923 ,Statement of Dermatoallergy Working Group of the Turkish Society of Dermatology-, TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY, cilt.54, ss.71-75, 2020 [SALMAN A., Alper S., Atakan N., BÜLBÜL BAŞKAN E., BORLU M., Canpolat F., Erdem T., Erdem Y., Gul U., Kartal S. P. , et al., -Recommendations on the use of systemic treatments for urticaria and atopic dermatitis during the COVID-19 pandemic] ,urticaria ,dupilumab ,Pandemic ,lcsh:Dermatology ,medicine ,Atopic dermatitis ,COVID-19 ,Dupilumab ,Omalizumab ,Treatment ,Urticaria ,atopic dermatitis ,treatment ,Medicine ,Dermatology ,business.industry ,lcsh:RL1-803 ,lcsh:Diseases of the genitourinary system. Urology ,medicine.disease ,language.human_language ,covid-19 ,language ,omalizumab ,business - Abstract
NA
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- 2020
22. Molecular skin changes in Cushing syndrome and the effects of treatment
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Fahrettin Kelestimur, Murat Borlu, Sedat Tarik Firat, Serpil Taheri, Ecmel Mehmetbeyoglu, A Sezgin Caglar, Fatih Tanriverdi, Gokmen Zararsiz, K. Unluhizarci, Aysa Hacioglu, and Zuleyha Karaca
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Adult ,Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,030209 endocrinology & metabolism ,Growth hormone receptor ,Skin Diseases ,03 medical and health sciences ,Cushing syndrome ,0302 clinical medicine ,Endocrinology ,Internal medicine ,Biopsy ,medicine ,Humans ,Prospective Studies ,Cushing Syndrome ,Acne ,Messenger RNA ,integumentary system ,biology ,medicine.diagnostic_test ,business.industry ,Adrenalectomy ,Middle Aged ,Prognosis ,medicine.disease ,Cytokine ,Case-Control Studies ,030220 oncology & carcinogenesis ,Skin biopsy ,biology.protein ,Female ,business ,Elastin ,Biomarkers ,Follow-Up Studies - Abstract
Objective We investigated newly diagnosed patients with endogenous CS for molecular changes in skin by biopsy before and a year after treatment of CS. Patients and methods 26 Patients with CS and 23 healthy controls were included. All the patients were evaluated before and a year after treatment. Skin biopsies were obtained from abdominal region before and a year after treatment in patients with CS and once from healthy volunteers. Total RNA was isolated from the skin biopsy samples and the real-time PCR system was used to determine the expression levels of 23 genes in the skin biopsy. Results Skin expression levels of HAS 1, 2 and 3 mRNAs were lower and COL1A2, COL2A1, COL3A1 mRNAs were higher in patients with CS than in normal controls. MMP-9, TIMP-1 and elastin mRNA expression levels were similar in two groups. Skin IL-1 beta mRNA expression level was significantly higher in patients with CS. None of these parameters changed significantly 12 months after treatment. Patients with CS showed higher skin GH and HSD11B1 mRNA expressions and lower GHR and IGF-1R mRNA expression compared to control. Expression levels of IGF-1, GR and HSD11B2 mRNA were similar in two groups. None of these parameters changed significantly 12 months after treatment. Conclusion CS is associated with increased expression levels of skin COL1A2, COL2A1, COL3A1 mRNAs (which are correlated with increased expression level of skin GH mRNA). Decreased skin HAS may cause decreased synthesis of HA that contributes to thinning of skin in CS. Increased local inflammatory cytokine and HSD11B1 mRNAs may be related to the acne formation in CS. Treatment of CS was not able to reverse these changes and ongoing changes were detected after treatment.
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- 2020
23. The accumulation of lncRNAs in hybrid with DNA in patients with psoriasis reveals a decrease in the levels of RNase HII transcripts in the skin
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Serpil Taheri, Murat Borlu, Ecmel Mehmetbeyoglu, Zeynep Yilmaz, Leila Kianmehr, Hassan Rajabi-Maham, Seyma Basar Kilic, and Minoo Rassoulzadegan
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Genome instability ,chemistry.chemical_compound ,Telomeric repeat-containing RNAs ,chemistry ,Heterochromatin ,RNA ,Epigenome ,Biology ,Cell aging ,DNA ,Telomere ,Cell biology - Abstract
Long functional non-coding RNAs (lncRNAs) have been in the limelight in aging research because short telomeres are associated with higher levels of TERRA (Telomeric Repeat containing RNA). The genomic instability caused in Immune-mediated inflammatory diseases (IMID) especially in patients with psoriasis, which lead to short telomeres in psoriasis lesions, is a mechanism leading to cell aging. Research on the fraction of TERRA in hybrid with DNA offers avenues for new strategies. Skin samples were fractionated to obtain the RNA associated with DNA as a R-loop structure. TERRA analysis was performed by RT-qPCR and RNA-seq analysis. The higher amount of TERRA levels attached with each chromosome end was found with psoriasis patients. The increased levels of TERRA linked with telomeres correlate with the decrease in the RNase-HII transcript which means the unresolved DNA/RNA hybrids may ultimately facilitate the formation of skin lesions. LncRNAs have multiple molecular functions, including the regulation of heterochromatin, which controls genome stability and epigenome shaping and may be used as a trans-generational prognostic marker in patients with psoriasis.
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- 2021
24. A multicentre prospective analysis of the incidence of pemphigoid diseases in Turkey
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Yıldız Gürsel Ürün, Havva Hilal Ayvaz Çelik, Begüm Güneş, Mehmet Melikoglu, Ezgi Özkur, Mehmet Harman, Leyla Baykal Selçuk, Şebnem Aktan, Ekin Şavk, Kıymet Inan, Hatice Sanli, Rukiye Güner, Derya Mutlu, Murat Borlu, Savaş Yayli, Eda Öksüm Solak, Murat Durdu, Didem Dizman, Mualla Polat, Munise Daye, Burçin Cansu Bozca, Incilay Kalay Yildizhan, Şeniz Duygulu, Mehmet Kamil Mülayim, Erdal Pala, Zuleyha Ozgen, Demet Cicek, Betül Demir, Mustafa Anıl Yılmaz, Selin Işık, Arzu Kiliç, Hilal Kaya Erdoğan, İjlal Erturan, Servinaz Enli, Sinan Özçelik, Kamer Gündüz, Ali Haydar Eskiocak, Bilge Fettahlıoğlu Karaman, Işıl Göğem İmren, Soner Uzun, and DİZMAN, DİDEM
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bullous pemphigoid ,Male ,demography ,Pemphigoid ,age distribution ,Turkey ,very elderly ,preschool child ,incidence study ,Turkey (republic) ,cardiovascular disease ,immune system diseases ,middle aged ,Pemphigoid, Bullous ,Prospective Studies ,Child ,skin and connective tissue diseases ,Aged, 80 and over ,integumentary system ,adult ,Incidence ,Incidence (epidemiology) ,benign mucous membrane pemphigoid ,pemphigus ,clinical trial ,pemphigoid gestationis ,neurologic disease ,aged ,female ,Child, Preschool ,histopathology ,young adult ,diagnostic procedure ,tertiary care center ,Bullous pemphigoid ,acquired epidermolysis bullosa ,prospective study ,Epidermolysis bullosa acquisita ,medicine.medical_specialty ,pemphigoid ,Adolescent ,Dermatology ,Article ,turkey (bird) ,mucous membrane pemphigoid ,Pemphigoid Gestationis ,medicine ,Humans ,controlled study ,epidermolysis bullosa ,human ,immunofluorescence ,Sex Distribution ,skin biopsy ,Benign Mucous Membrane Pemphigoid ,DURDU M., Bozca B. C. , ENLİ S., Yazici Ozgen Z., YAYLI S., AKTAN Ş., MUTLU D., ERTURAN İ., AYVAZ ÇELİK H. H. , MELİKOĞLU M., et al., -A multicentre prospective analysis of the incidence of pemphigoid diseases in Turkey-, AUSTRALASIAN JOURNAL OF DERMATOLOGY, 2021 ,business.industry ,sex ratio ,medicine.disease ,major clinical study ,human tissue ,eye diseases ,clinical feature ,enzyme linked immunosorbent assay ,Pemphigus ,multicenter study ,Etiology ,dipeptidyl peptidase IV inhibitor ,business - Abstract
Background: The differentiation between the pemphigoid diseases is essential for treatment and prognosis. In Turkey, data on the incidence of these diseases are insufficient. Our aim in this study is to determine the incidence, demographics and clinical characteristics associated with diseases of the pemphigoid group. Methods: We prospectively analysed 295 patients with pemphigoid who visited dermatology clinics of tertiary referral hospitals in 12 different regions of Turkey within a year. The diagnosis was based on clinical, histopathological, direct immunofluorescence (DIF) and serological (multivariant enzyme-linked immunosorbent assay [ELISA], indirect immunofluorescence and mosaic-based BIOCHIP) examinations. Clinical and demographic findings, aetiological factors and concomitant diseases observed in the patients were recorded. Results: A total of 295 (female/male ratio: 1.7/1) patients with pemphigoid were diagnosed in 1-year period. The overall incidence rate of pemphigoid diseases was found to be 3.55 cases per million-years. The ratio of pemphigoid group diseases to pemphigus group diseases was 1.6. The most common pemphigoid type was bullous pemphigoid (BP, 93.2%). The others were epidermolysis bullosa acquisita (3.1%), pemphigoid gestationis (2.4%), linear IgA disease (1%) and mucous membrane pemphigoid (0.3%). The most common (26.8%) possible trigger of the bullous pemphigoid was gliptin derivative drugs. The most common concomitant diseases with pemphigoid were cardiovascular (27.8%) and neurological diseases (23.7%). Conclusions: This study showed that the increased frequency of bullous pemphigoid reversed the pemphigoid/pemphigus ratio in Turkey. Further studies are warranted regarding the reasons for this increase. © 2021 The Australasian College of Dermatologists
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- 2021
25. The impact of COVID-19 pandemic on psoriasis patients, and their immunosuppressive treatment: a cross-sectional multicenter study from Turkey
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Oğuz Yılmaz, Esma İnan Yüksel, Levent Donmez, Ali Bozdağ, Selim Kartal, Müge Güler Özden, Nida Kaçar, Erkan Alpsoy, Gökçen Yuvali Çelik, Selda Pelin Kartal, Begüm Ünlü, Hayriye Sarıcaoğlu, Sevim Baysak, Melis Gönülal, Sema Aytekin, Eda Öksüm Solak, Tuba Kevser Üstünbaş, Burhan Engin, Neslihan Şendur, Busra Demirbag Gul, Gökhan Çınar, Münevver Güven, Didem Didar Balci, Ayça Cordan Yazici, Asena Çiğdem Doğramacı, Bilal Dogan, Murat Borlu, Server Serdaroğlu, and Demet Cicek
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Drug ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Turkey ,media_common.quotation_subject ,Population ,immunosuppressive drugs ,Dermatology ,Disease ,Anxiety ,treatment adherence ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Drug withdrawal ,0302 clinical medicine ,Rates ,Internal medicine ,Psoriasis ,Pandemic ,medicine ,Humans ,biologics ,education ,Pandemics ,media_common ,030203 arthritis & rheumatology ,education.field_of_study ,Biological Products ,business.industry ,Incidence (epidemiology) ,COVID-19 ,medicine.disease ,Cross-Sectional Studies ,Tumor Necrosis Factor Inhibitors ,business ,Immunosuppressive Agents - Abstract
© 2021 Taylor & Francis Group, LLC.Background: Immunosuppressive therapy has been a great concern during the pandemic. This study aimed to evaluate the pandemic's impact on psoriasis patients treated with immunosuppressive drugs. Material and Methods: The multicenter study was conducted in 14 tertiary dermatology centers. Demographic data, treatment status, disease course, and cases of COVID-19 were evaluated in patients with psoriasis using the immunosuppressive treatment. Results: Of 1827 patients included, the drug adherence rate was 68.2%. Those receiving anti-interleukin (anti-IL) drugs were more likely to continue treatment than patients receiving conventional drugs (OR = 1.50, 95% CI, 1.181–1.895, p =.001). Disease worsening rate was 24.2% and drug dose reduction increased this rate 3.26 and drug withdrawal 8.71 times. Receiving anti-TNF or anti-IL drugs was associated with less disease worsening compared to conventional drugs (p =.038, p =.032; respectively). Drug withdrawal causes were ‘unable to come’ (39.6%), ‘COVID concern’ (25.3%), and ‘physician’s and patient’s co-decision’ (17.4%). Four patients had COVID-19 infection with mild symptoms. The incidence was 0.0022% while it was 0.0025% in the general population. Conclusion: Our study shows that psoriasis patients using systemic immunosuppressive do not have a higher, but even lower COVID-19 risk than the general population, and treatment compliance with biological drugs is higher.
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- 2021
26. Evaluation of Trichoscopic Findings of Tractional Alopecia
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Özlem Karadağ Köse and Murat Borlu
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Dermatology ,Biology - Published
- 2019
27. Differences in skin lesions of endogenous and exogenous Cushing’s patients
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Yasin Simsek, Hasan Keleştemur, Murat Borlu, and Fatma Erden
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Hypertrichosis ,lcsh:Internal medicine ,medicine.medical_specialty ,Dermatology ,dermatological findings ,endogenous Cushing’s ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Atrophy ,lcsh:Dermatology ,medicine ,Immunology and Allergy ,lcsh:RC31-1245 ,Acanthosis nigricans ,Acne ,hirsutism ,Original Paper ,business.industry ,lcsh:RL1-803 ,medicine.disease ,Hyperpigmentation ,Purpura ,skin alterations ,Cushing’s syndrome ,exogenous Cushing’s ,medicine.symptom ,business ,Rare disease - Abstract
Introduction Cushing's syndrome is a rare condition characterized by increased glucocorticoid levels. Dermatologically, it causes a variety of skin conditions such as atrophy, striae, acne, plethora, hypertrichosis, hirsutism, acanthosis nigricans, hyperpigmentation, alopecia, purpura and fragile skin. Although skin lesions of Cushing's syndrome have been described, exogenous and endogenous types have not been studied in detail. Aim To determine differences in possible skin lesions depending on the cause of Cushing's syndrome. Material and methods A total of 35 patients - 16 iatrogenic Cushing's syndrome patients and 19 endogenous Cushing's syndrome patients - who were diagnosed in Erciyes University and 15 healthy individuals were included in this study. Results There was at least one skin finding in 34 (97.1%) of the patients with Cushing's syndrome and 9 (60%) in the control group (p = 0.001). Comparison regarding skin findings in patient and control groups revealed that hypertrichosis, hyperpigmentation, and fungal infections were significantly more frequent in the patient group than the control group. Hirsutism was found more frequently in the endogenous group whereas stria, hypertrichosis and fungal infections were more frequent in the exogenous group. Conclusions Since Cushing's syndrome is a rare disease and it is often diagnosed later in life, data on the frequency of skin findings are limited and sparse in the literature. In the comparison of endogenous Cushing's and exogenous Cushing's groups, acne, hypertrichosis, and fungal infections were found more frequently in the exogenous Cushing's group and hirsutism more frequently in the endogenous Cushing's group.
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- 2019
28. Efficacy and Safety Data for Rituximab (Anti-CD20) in the Treatment of Pemphigus Vulgaris: A Retrospective, Single-Center Study
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Gözde Emel Gökçek, Demet Kartal, Murat Borlu, Salih Levent Çinar, and Eda Öksüm Solak
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medicine.medical_specialty ,genetic structures ,integumentary system ,business.industry ,Pemphigus vulgaris ,Single Center ,medicine.disease ,Dermatology ,immune system diseases ,hemic and lymphatic diseases ,Medicine ,Rituximab ,Anti cd20 ,business ,skin and connective tissue diseases ,medicine.drug - Abstract
Objective: The aim of the study was to evaluate the efficacy and safety of rituximab treatment in patients with pemphigus vulgaris.
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- 2021
29. Evaluation of the causes affecting the development of pruritus in patients with peritoneal dialysis
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Ali Gundogdu, Cigdem Karakukcu, Bulent Tokgoz, Murat Borlu, Sumeyra Koyuncu, Cihan Uysal, Murat Hayri Sipahioglu, Eda Öksüm Solak, Gokmen Zararsiz, Oktay Oymak, and Ismail Kocyigit
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Nephrology ,Adult ,Male ,medicine.medical_specialty ,Visual analogue scale ,Urology ,medicine.medical_treatment ,030232 urology & nephrology ,030204 cardiovascular system & hematology ,Gastroenterology ,Severity of Illness Index ,Peritoneal dialysis ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Peritoneal Dialysis, Continuous Ambulatory ,Internal medicine ,medicine ,Humans ,In patient ,Vitamin B12 ,Aged ,business.industry ,Pruritus ,Continuous ambulatory peritoneal dialysis ,Middle Aged ,Pathophysiology ,Cross-Sectional Studies ,Female ,business - Abstract
Background Several factors play a role in the pathogenesis of pruritus in uremic patients. The pathophysiology is complex and many factors have been identified in these patients. The aim of this study was to investigate the presence, severity, and possible causes of pruritus in patients with peritoneal dialysis (PD) . Methods Eighty patients, who received continuous ambulatory peritoneal dialysis (CAPD) treatment, were included in this study. Biochemical measurements, parathormone, C-reactive protein (CRP), and vitamin B12 levels of all the patients were recorded. Furthermore, substance P (SP) levels were measured by ELISA methods. Patients were examined by a dermatologist and pruritus degrees were queried using the visual analog score (VAS) with skin dryness. Results In generalized linear model analysis, total urea clearance and SP independently predicted VAS scores. SP was significantly predictive in ROC analysis in identifying the VAS score in patients with peritoneal dialysis. The sensitivity and specificity of SP were 80% and 67% (cut-off > 364), respectively, with an area under the ROC curve of 0.757 (95% CI 0.650-0.865, p < 0.001). SP also was significantly predictive in ROC analysis in identifying xerosis in PD patients. Conclusion Pruritus was proportional to the amount of substance P and total urea clearance was another reason affecting pruritus in peritoneal dialysis patients.
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- 2021
30. The relationship between the severity of coronary artery disease and skin measurement parameters
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Nihat Kalay, Demet Kartal, Eda Öksüm Solak, Gözde Emel Gökçek, Goktug Savas, Murat Borlu, and Salih Levent Çinar
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medicine.medical_specialty ,Dermatology ,Coronary Artery Disease ,01 natural sciences ,010309 optics ,Coronary artery disease ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Forearm ,Internal medicine ,Skin Physiological Phenomena ,0103 physical sciences ,medicine ,Humans ,In patient ,Patient group ,Normal range ,Skin ,Transepidermal water loss ,integumentary system ,business.industry ,Skin temperature ,Hydrogen-Ion Concentration ,medicine.disease ,Water Loss, Insensible ,Sebum ,body regions ,medicine.anatomical_structure ,Forehead ,Cardiology ,business - Abstract
Purpose This study aimed to investigate the relationship between skin parameters and CAD. Materials and methods The study included 50 patients diagnosed with coronary artery disease as the patient group and 45 volunteers without any known coronary artery disease as the control group. The participants' skin TEWL, pH, temperature, electrical capacitance, sebum, and elasticity values were measured using noninvasive methods at the forehead, back, and forearm. Findings Skin temperature was significantly higher in the back and forehead regions in the patient group. No difference was found between the sebum values of the patient and control groups at the back and forehead. A significantly higher result was obtained for the forearm area. The pH was significantly lower in the patients' forearm, although the obtained values were within the normal range. The TEWL was significantly higher in patients in all three regions. In terms of flexibility, R2 was significantly higher in the back and forehead regions of the patient group, and the R6 was significantly higher in the patient group in all three regions. In addition, there was no correlation between skin parameter and SYNTAX score increase measurements. Conclusion It can be suggested that skin sebum and TEWL measurements can be accepted as cheap and noninvasive methods of predicting CAD.
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- 2021
31. Nekrobiosis Lipoidica in a Pediatric Patient
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Emine Çölgeçen, Gözde Emel Gökçek, Özge Şeyda Şaka, Murat Borlu, and Özlem Canöz
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Pediatric patient ,Pediatrics ,medicine.medical_specialty ,business.industry ,Medicine ,business - Abstract
Necrobiosis lipoidica is a rare chronic granulomatous disease that has historically been associated with diabetes mellitus, but recently it is thought to be secondary to microangiopathic changes. We report a necrobiosis lipoidica case of a five-year-old girl with diabetes since the age of two, because it is exceptionally unusual in pediatric diabetes. Necrobiosis lipoidica should be considered in pediatric patients with slowly expanded erythematous plaques and patches. This will help protect the patient from other important diabetic microangiopathic complications, such as nepropathy and retinopathy and also malignant progression, such as squamous cell carcinoma.
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- 2021
32. Cutaneous symptoms of patients diagnosed with COVID‐19 in one province: a cross‐sectional survey
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Salih Levent Çinar, Murat Borlu, Ali Ramazan Benli, Demet Kartal, Humeyra Aslaner, Eda Öksüm Solak, and Burcu Baran Ketencioglu
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0301 basic medicine ,Dermatological findings ,Adult ,Male ,Pediatrics ,medicine.medical_specialty ,2019-20 coronavirus outbreak ,China ,Coronavirus disease 2019 (COVID-19) ,Adolescent ,Cross-sectional study ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,030106 microbiology ,Dermatology ,Skin Diseases ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Surveys and Questionnaires ,medicine ,Humans ,Patient group ,Aged ,Aged, 80 and over ,business.industry ,Incidence ,COVID-19 ,Middle Aged ,Rash ,Cross-Sectional Studies ,Infectious Diseases ,Female ,medicine.symptom ,business - Abstract
The COVID-19 infection, which emerged in December 2019 in China and has spread all over the world,1 continues to be a serious health problem and many dermatological findings have been reported.2-6 This study patients who had at least one positive COVID-19-PCR sample in Kayseri province and were followed up and treated for COVID-19 were contacted via the Internet and telephone. Hence, patients who might have been misdiagnosed were excluded. This way, data of a more specific patient group could be evaluated.
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- 2021
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33. Multicenter study evaluating the impact of <scp>COVID</scp> ‐19 outbreak on dermatology outpatients in Turkey
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Zehra Aşiran Serdar, Dilek Bayramgürler, Sema Aytekin, Müge Güler Özden, Server Serdaroğlu, Gökçen Yuvali Çelik, Selda Pelin Kartal, Levent Donmez, Neslihan Şendur, Demet Cicek, Nida Kaçar, Hayriye Sarıcaoğlu, Bilal Dogan, Murat Borlu, Didem Didar Balci, Ayça Cordan Yazici, Erkan Alpsoy, Asena Çiğdem Doğramacı, Bursa Uludağ Üniversitesi/Tıp Fakültesi/Deri ve Zührevi Hastalıklar Anabilim Dalı., Sarıcaoğlu, Hayriye, and DPU-8534-2022
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Skin ,Allergic Contact Dermatitis ,COVID-19 ,pityriasis rosea ,Skin disease ,Turkey (republic) ,Infant, newborn ,urticaria ,030207 dermatology & venereal diseases ,0302 clinical medicine ,Outpatients ,Pandemic ,Scabies ,Medicine ,Outpatient clinic ,Child ,Middle aged ,Disease outbreaks ,outpatient care ,Aged, 80 and over ,skin cancer ,adult ,Incidence (epidemiology) ,Outpatient ,irritant dermatitis ,psoriasis ,sexually transmitted disease ,General Medicine ,dermatology ,Skin diseases ,Clinical trial ,female ,030220 oncology & carcinogenesis ,tertiary care center ,medicine.medical_specialty ,Adolescent ,Child, preschool ,Epidemic ,herpes zoster ,Dermatology ,Article ,coronavirus disease 2019 ,03 medical and health sciences ,male ,Humans ,human ,acne ,Aged ,dermatitis ,SARS-CoV-2 ,business.industry ,pandemic ,Public health ,dermatology outpatients ,Infant ,Very elderly ,Outbreak ,skin allergy ,Newborn ,medicine.disease ,major clinical study ,scabies ,Young adult ,multicenter study ,Preschool child ,Pityriasis rosea ,Irritant contact dermatitis ,business - Abstract
COVID-19 pandemic has a significant impact on public health, whether directly or indirectly. The first case was seen in Turkey on March 11, and the World Health Organization (WHO) declared a pandemic on March 12, 2020. The study aimed to document the effect of pandemic on dermatology outpatient clinics in Turkey. 15 tertiary hospitals from 13 provinces were included in the study, which was conducted between January 12 and May 12, 2020. The International Codes of Diseases (ICD-10) categories and patients' characteristics were evaluated before and after the pandemic. A total of 164878 patients, 133131 before and 31747 after the pandemic, were evaluated. The daily hospital applications were found reduced by 77%. The three of the most frequent diagnoses; dermatitis, acne, and psoriasis remained unchanged after the pandemic. While the frequency of herpes zoster, scabies, urticaria, pityriasis rosea and sexually transmitted diseases increased significantly; allergic and irritant contact dermatitis decreased after the pandemic. The applications regarding cutaneous neoplasms were considerably reduced during the pandemic, and this effect was more pronounced in cities with higher COVID incidence. The pandemic caused a noteworthy reduction in the number of patients accessing dermatological care. The pandemic caused significant changes in the frequency of a wide range of dermatological diseases. The application of cutaneous neoplasms is considerably reduced after the pandemic, and this effect was more pronounced in cities where pandemics are frequent. Therefore, the pandemic has resulted on numerous impacts on many critical issues in dermatology and dermatological care. This article is protected by copyright. All rights reserved.
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- 2020
34. Coronavirus Disease 2019 (COVID-19) Accompanied by Maculopapular Rash: A Case Study
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Murat Borlu, Burcu Baran Ketencioglu, Salih Levent Çinar, Demet Kartal, and Eda Öksüm Solak
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Allergy ,Livedo ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,business.industry ,General Engineering ,Infectious Disease ,Dermatology ,Disease ,030204 cardiovascular system & hematology ,medicine.disease_cause ,medicine.disease ,Erythematous rash ,sars-cov-2 ,03 medical and health sciences ,drug rash ,0302 clinical medicine ,Pandemic ,Maculopapular rash ,medicine ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Coronavirus - Abstract
A new type of coronavirus (coronavirus disease 2019; COVID-19), which emerged in the People's Republic of China, spread all over the world over time and became a pandemic. Dermatological symptoms seen during the course of the disease have gained importance over time. Studies have shown that many dermatological findings such as erythematous rash, urticaria, pseudo-chilblain, maculopapular, livedo/necrosis, and vesicular lesions may accompany the disease. In this study, a 24-year-old female patient with maculopapular lesions who had no previous history of allergy or dermatological disease and regressed without any dermatological treatment is presented.
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- 2020
35. Internalized Stigma in Pediatric Psoriasis: A Comparative Multicenter Study
- Author
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Murat Borlu, Neslihan Şendur, Basak Yalcin, Ayse Serap Karadag, Tulin Ergun, Kamer Gündüz, Pinar Dursun, Asli Bilgic, Mualla Polat, Ayla Gülekon, Gizem Yagcioglu, Pelin Kartal, Bilge Fettahlıoğlu Karaman, Ercan Arca, Ayça Cordan Yazici, Selma Emre, Ufuk Kavuzlu, Esra Adişen, Ibrahim Halil Yavuz, Erkan Alpsoy, Özlem Bilgiç, Didem Didar Balci, Rafet Koca, Serap Gunes Bilgili, Aslı Sürer Adanır, Yeşim Şenol, Ertan Yilmaz, Department of Dermatology and Venereology, Akdeniz University School of Medicine, Dumlupinar Boulevard, Konyaalti, Antalya, 07058, Turkey, Department of Dermatology and Venereology, Abant Izzet Baysal University School of Medicine, Bolu, Turkey, Department of Dermatology and Venereology, Van Yuzuncu Yil University School of Medicine, Van, Turkey, Department of Dermatology and Venereology, University of Health Sciences Ankara Diskapi, Yildirim Beyazit Education and Research Hospital, Ankara, Turkey, Department of Dermatology and Venereology, Izmir Tepecik Education and Research Hospital, Izmir, Turkey, Department of Dermatology and Venereology, Istanbul Medeniyet University School of Medicine, Istanbul, Turkey, Department of Dermatology and Venereology, Guven Hospital, Ankara, Turkey, Department of Dermatology and Venereology, Cukurova University School of Medicine, Adana, Turkey, Department of Dermatology and Venereology, Yildirim Beyazit University Ankara, Atatürk Education and Research Hospital, Ankara, Turkey, Department of Dermatology and Venereology, Gazi University Faculty of Medicine, Ankara, Turkey, Department of Dermatology and Venereology, Adnan Menderes University School of Medicine, Aydin, Turkey, Department of Dermatology and Venereology, Selcuk University School of Medicine, Konya, Turkey, Department of Dermatology and Venereology, Mersin University School of Medicine, Mersin, Turkey, Department of Dermatology and Venereology, Ankara Numune Training and Research Hospital, Ankara, Turkey, Department of Dermatology and Venereology, Bulent Ecevit University School of Medicine, Zonguldak, Turkey, Department of Dermatology and Venereology, Celal Bayar University School of Medicine, Manisa, Turkey, Department of Dermatology and Venereology, Erciyes University School of Medicine, Kayseri, Turkey, Department of Dermatology and Venereology, Marmara University School of Medicine, Istanbul, Turkey, Department of Dermatology and Venereology, Mersin State Hospital, Mersin, Turkey, Department of Child and Adolescent Psychiatry, Akdeniz University School of Medicine, Antalya, Turkey, Department of Medical Education, Akdeniz University School of Medicine, Antalya, Turkey, BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, and Polat, Mualla
- Subjects
Quality of life ,medicine.medical_specialty ,Pediatric psoriasis ,Stigma (botany) ,Dermatology ,Disease ,Stigmatization ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Psoriasis ,Internal medicine ,medicine ,Child ,Inflammation ,business.industry ,Dermatology Life Quality Index ,medicine.disease ,030220 oncology & carcinogenesis ,Quality of Life ,Original Article ,General Health Questionnaire ,business ,Body mass index - Abstract
Background: Internalized stigma, adoption of negative attitudes and stereotypes of the society regarding persons' illness, has not been studied previously in pediatric psoriasis patients. Objective: We aimed to investigate the internalized stigma in pediatric psoriasis patients and to determine differences according to factors affecting internalized stigma compared to adult psoriasis patients. Methods: This multicenter, cross-sectional, comparative study included 125 pediatric (55 female, 70 male; mean age±standard deviation [SD], 14.59±2.87 years) and 1,235 adult psoriasis patients (577 female, 658 male; mean age±SD, 43.3±13.7 years). Psoriasis Internalized Stigma Scale (PISS), Dermatology Life Quality Index (DLQI), Perceived Health Status (PHS), and the General Health Questionnaire (GHQ)-12 were the scales used in the study. Results: The mean PISS was 58.48±14.9 in pediatric group. When PISS subscales of groups were compared, the pediatric group had significantly higher stigma resistance (p=0.01) whereas adult group had higher scores of alienation (p=0.01) and stereotype endorsement (p=0.04). There was a strong correlation between mean values of PISS and DLQI (r=0.423, p=0.001). High internalized stigma scores had no relation to either the severity or localization of disease in pediatric group. However, poor PHS (p=0.007) and low-income levels (p=0.03) in both groups, and body mass index (r=0.181, p=0.04) in the pediatric group were related to high PISS scores. Conclusion: Internalized stigma in pediatric patients is as high as adults and is related to poor quality of life, general health, and psychological illnesses. Unlike adults, internalized stigma was mainly determined by psoriasis per se, rather than disease severity or involvement of visible body parts, genitalia or folds. Copyright © The Korean Dermatological Association and The Korean Society for Investigative Dermatology.
- Published
- 2020
36. Efficacy of the combination of Q-switched Nd:YAG laser and microneedling for melasma
- Author
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Özlem Karadağ Köse and Murat Borlu
- Subjects
medicine.medical_specialty ,Treatment protocol ,Melasma ,Dermatology ,Lasers, Solid-State ,Melanosis ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Recurrence ,Female patient ,Medicine ,Humans ,business.industry ,Multimodality Treatment ,medicine.disease ,Combined Modality Therapy ,Mesotherapy ,Treatment Outcome ,030220 oncology & carcinogenesis ,Nd:YAG laser ,Face ,Female ,business ,After treatment - Abstract
Background Melasma is a common, multifactorial, and recurring disease which is not easy to treat. Aims The purpose of this study is to evaluate the efficacy of microneedling in combination with Q-switched neodymium-doped yttrium aluminum garnet laser (QsNd-YAG laser) for treatment of melasma. Patients/methods Fifteen female patients with epidermal or mixed-type melasma on the face were included in the study. Patients were first treated with QsNd-YAG laser, and then with microneedling containing mesotherapy products of biomimetic peptides, at the same session. Modified Melasma Area Severity Index (mMASI) scores were calculated before the first session and again 2 weeks after the last session. The same treatment protocol was repeated every 2 weeks for five sessions within period of 3 months of therapy. The evaluation was performed according to the before and after photographs taken from three angles including 90-degree front and 45 degrees from left and right with the VISIA device. Results Of the 15 patients included in the study, the mean mMASI scores before and after treatment were 9.2 ± 5.7 (3.8-23.1) and 3.6 ± 4.0 (0.6-16.8), respectively. mMASI scores were significantly reduced after completion of the protocol. Six (40%) patients had "very good response," 4 (26.7%) patients had "good response," and 5 (33.3%) patients were "unresponsive." Six (40%) patients were followed up for 1 year, and only 1 patient had a recurrence (6.7%). Conclusions In addition to the use of photoprotective measures, multimodality treatment including QsNd-YAG laser and microneedling with mesotherapy products containing biomimetic peptides is effective to treat melasma and they work synergistically.
- Published
- 2020
37. Systemic Sclerosis
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Murat Borlu and Eda Öksüm Solak
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030203 arthritis & rheumatology ,0301 basic medicine ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,integumentary system ,InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL ,skin and connective tissue diseases ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) - Abstract
Systemic sclerosis (SSc) is a chronic, autoimmune disease which can affect the blood vessels, the visceral organs, and the skin. SSc, most commonly, develops between the ages of 30 and 50, but it can be seen at any age. In terms of skin involvement, SSc can be classified as limited or diffuse. Its etiopathogenesis is still unclear. Microvascular dysfunction is thought to be followed by immunological activation, collagen and extracellular matrix deposition, and finally fibrosis. Diagnosis is based on clinical presentation. Sclerosis of the metacarpophalangeal and/or metatarsophalangeal joints is the major diagnostic criterion, whereas sclerodactylia, digital ulcers (DU), and pulmonary fibrosis are the minor criteria. SSc is diagnosed with one major criterion or two minor criteria. Detection of autoantibodies can help the diagnosis. Antinuclear antibody (ANA), anti-centromere antibody, anti-scl 70, RNA polymerase 1 and 3, and anti-fibrillin antibody can be found positive in SSc. SSc must be differentiated from all sclerosing diseases and the diseases with Raynaud’s phenomenon. Visceral diseases, such as primary pulmonary hypertension, primary biliary cirrhosis, and infiltrative cardiomyopathy, should also be considered in its differential diagnosis. The main treatment goal is to target visceral involvement.
- Published
- 2020
38. VİTİLİGO TANILI HASTALARDA İNTERFERON-GAMMA/ İNTERLÖKİN-10 ORANININ HASTALIK AKTİVİTESİ VE YAYGINLIĞI İLE İLİŞKİSİ
- Author
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Eda Öksüm Solak, Gözde Emel Gökçek, Murat Borlu, Demet Kartal, and Salih Levent Çinar
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medicine.medical_specialty ,business.industry ,medicine ,General Medicine ,business ,Dermatology - Abstract
Amaç: Bu çalışmada vitiligolu hastaların serumlarında proinflamatuvar karakterde olan interferon-gamma (IFN-γ) ve antiinflamatuvar karakterde olan interlökin (IL)-10 seviyeleri ve bu sitokinlerin birbiriyle olan oranı; bunların hastalığın yaygınlığı ve aktivitesi ile ilişkili olup olmadığını araştırmak amaçlanmıştır. Gereç ve Yöntem: Çalışmaya klinik olarak vitiligo tanısı konulan 42 hasta ve 42 kontrol alındı. Serum IFN-γ, IL-10, antinükleer antikor (ANA), C-reaktif protein (CRP) seviyeleri ölçüldü; vitiligo alan şiddet indeksi (VASI) ve vitiligo hastalık aktivite skoru (VIDA) değerleri hesaplandı ve uygun istatiksel analizler yapıldı. Bulgular: Hasta ve kontrol grubu arasında IFN-γ, IL-10,ANA, CRP seviyeleri ve IFN-γ / IL-10 oranı açısından anlamlı fark bulunmadı. VASI > 200 (yaygın tutulumlu hastalar) olan hastalarla, kontrol grubu karşılaştırıldığında IL-10 değerleri arasında anlamlı farklılık saptandı (p= 0,02). VIDA > 2 (son 6 ayda yeni lezyon çıkışı olan, aktif hastalar) hastalarda IL-10 seviyeleri arasında yapılan korelasyon analizinde serum IL-10 değerinin pozitif yönde etki etkilendiği gözlendi (p= 0,028, r= 0,656). Hastalık süresinin IL-10 üzerine etkisi olup olmadığı değerlendirildiğinde korelasyon saptandı (p= 0,034). Bu korelasyonun negatif yönde orta derecede ilişkili olduğu saptandı (r = -0,502). IFN-γ / IL-10 oranı VASI >200 olan hastalar ile VIDA >2 olan hastalarda kontrole kıyasla anlamlı derecede yüksek bulundu (p= 0,04, p= 0,018). Sonuç: Çalışmamızda en çok dikkat çeken sonuç, IL-10 seviyesinin hastalığın aktif döneminde ve yaygın tutulumu olan hastalarda anlamlı derecede yüksek bulunmasıydı. Bu çalışma, yüksek sitokin seviyelerinin, melanosit hasarının daha geniş alanlarda gözlenmesinin nedeni olduğunu ve vitiligo patogenezinde otoimmün sürecin önemli derecede katkısı olduğunu göstermiştir.
- Published
- 2020
39. Evaluation of videodermoscopic features of chemotherapy induced alopecias
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Cengiz Akosman, Murat Borlu, Özlem Karadağ Köse, İstinye Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Anestezi Bölümü, and Akosman, Cengiz
- Subjects
Trichoscopy ,Chemotherapy Induced Alopecia ,Videodermoscopy ,Kemoterapi ,Alopesi ,Kemoterapi ile İndüklenen Alopesi ,Chemotherapy ,Alopecia ,Dermoscopy ,Videodermoskop ,Dermatology ,Dermoskopi ,Trikoskopi - Abstract
Amaç: Kemoterapiyle indüklenen alopesi, onkoloji hastalarında psikososyal açıdan kanser tedavisinin en yıkıcı bulgularından bir tanesidir. Bu çalışmada, kemoterapiyle indüklenen alopesilerin değerlendirilmesinde videodermoskopik incelemenin yerinin belirlenmesi amaçlanmıştır. Gereç ve Yöntemler: Çalışmaya, kemoterapi alan ve klinik inceleme sonrası kemoterapiyle indüklenen alopesi tanısı konan ardışık 41 hasta dâhil edildi. Hastaların yaş, cinsiyet, deri fototipi, malignite tanısı, tedavi protokolündeki kemoterapi ajanları ve alopesinin yaygınlığı kaydedildi. Trikoskopik fotoğraflar X30-X50’lik büyütmeler ile elde edildi. Literatürdeki yayınlar ile oluşturulan kontrol listesine göre trikoskopik bulgular incelendi. Bulgular: Foliküler bulgulardan olan saç çapı değişkenliği hastaların tümünde saptandı. Siyah nokta %78, sarı nokta %75,6, kırık saç %51,2, Pohl-Pinkus %46,3, ünlem işareti saçlar ve alev figürleri %26,8 oranında izlendi. İki renkli, kısa vellus ve moniletrix-benzeri saçlar %22, domuz kuyruğu ve incelen saç %19,5, lale saç %14,6 ve zig zag saç ise %9,8 oranında görüldü. Daha nadir izlenen diğer bulgular V saç %7,3, virgül saç, peripilar bulgu ve boş folikül ise %4,9 oranında idi. Nötrofil benzeri saç (%7,3) ilk kez tanımlandı. Sonuç: Kemoterapi ile indüklenen alopesilerde zig zag saç, lale saç ve V saç yeni trikoskopik bulgulardı. Nötrofil benzeri saçlar ise ilk kez bu çalışmada tanımlandı. Kemoterapiyle indüklenen alopesilerin dermoskopisi, alopesi areata ve trikotillomani ile bazı benzer bulgular göstermektedir. Objective: Chemotherapy induced alopecia is one of the most devastating findings of cancer treatment for oncology patients psychologically. In this study, we aimed to investigate the significance of videodermoscopic features of chemotherapy induced alopecia. Material and Methods: Fourty-one patients, who were treated with chemotherapy and were diagnosed as chemotherapy induced alopecia after clinical evaluation, were included. The age, gender, skin phototype, diagnosis of malignancy, chemotherapy agents in the treatment protocol, location of the alopecia and the severity of alopecia were recorded. Trichoscopic photos were held in X30-X50 fold magnifications. All of the trichoscopic findings were examined in accordance with the checklist which was described by the features of the previous publications. Results: Hair diameter diversity were detected in all of the patients as a follicular feature. Black dots were established in 78%, yellow dots in 75.6%, broken hairs in 51.2%, Pohl-Pinkus in 46.3%, exclamation mark hairs and flame figures in 26.8% of the patients. Bicoulored, short vellus and moniletrix-like hairs were detected in 22%, pigtail and tapering hairs in 19.5%, tulip hairs in 14.6% and zigzag hairs in 9.8% of the patients. V hairs in 7.3%, comma hairs, peripilar finding and empty follicles were established in 4.9% of the patients as other rare findings. Neutrophil like hairs were detected in 7.3% of the patients for the first time. Conclusion: Zigzag hair, tulip hair and V hair were the new trichoscopy findings in chemotherapy induced alopecia. Neutrophil like hairs were defined for the first time in this study. Dermoscopic features of chemotherapy induced alopecia indicates some similar findings for alopecia areata and trichotillomania.
- Published
- 2020
40. Trichoscopy of Diffuse Syphilitic Alopecia
- Author
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Murat Borlu and Özlem Karadağ Köse
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medicine.medical_specialty ,Syphilitic alopecia ,business.industry ,medicine ,Syphilis ,Dermatology ,business ,medicine.disease ,Trichoscopy - Published
- 2018
41. AB0579 INSTRUMENTS FOR SCREENING PSORIATIC ARTHRITIS AMONG PATIENTS WITH PSORIASIS: A SYSTEMATIC LITERATURE REVIEW
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E. Ozsoy Adisen, E Bulbul Baskan, Neslihan Akdogan, Serdal Ugurlu, Nilgün Atakan, Murat Borlu, Fatos Onen, E. Oksum Solak, Savaş Yayli, Vedat Hamuryudan, Sedat Kiraz, Basak Yalici-Armagan, Ayse Ozdede, M. Bektaş, Gulen Hatemi, Gizem Ayan, Gerçek Can, Umut Kalyoncu, Serkan Yazici, Murat Inanc, and Burhan Engin
- Subjects
medicine.medical_specialty ,business.industry ,Immunology ,Disease ,medicine.disease ,General Biochemistry, Genetics and Molecular Biology ,Rheumatology ,Optimal management ,Psoriatic arthritis ,Systematic review ,Psoriasis ,Internal medicine ,Epidemiology ,Immunology and Allergy ,Medicine ,In patient ,business - Abstract
Background:Timely diagnosis is essential for the optimal management of psoriatic arthritis (PsA). Several instruments have been developed for screening PsA among patients with psoriasis. However, a delay in diagnosis is still frequently reported, possibly due to the lack of a wide use of these instruments.Objectives:We aimed to identify and compare the reported performance of these instruments with special emphasis on the PsA phenotypes.Methods:We conducted a systematic literature search on PubMed until 15 August 2020 using the keyword ‘psoriatic arthritis’. Two independent reviewers identified all studies published in English, that report on the validation, psychometric evaluation or use of an instrument for screening PsA. Any disagreements were resolved by the third investigator. Data on sensitivity, specificity, positive (PPV) and negative (NPV) predictive values were extracted or calculated for each instrument. Additionally, instruments were assessed for their performance in patients with different disease phenotypes.Results:A total of 10754 references were screened, and 42 were identified that reported on 15 different screening instruments. Psoriatic Arthritis Screening and Evaluation (PASE), Psoriasis Epidemiology Screening Tool (PEST), Early Arthritis for Psoriatic Patients questionnaire (EARP) were the most commonly used instruments. There was important variability across studies regarding the sensitivity, specificity, PPV and NPV of these instruments based on the cut-offs for positivity, setting, patient population and disease phenotypes (Table 1). Specificity was higher when patients with a previous diagnosis of other rheumatic diseases were excluded. Lower sensitivity was reported among patients with shorter disease duration and when patients with a prior diagnosis of PsA were excluded from the study, whereas higher sensitivity was reported among patients with prior NSAID use. Screening tools showed differences in sensitivity in different domains (Figure 1).Figure 1.Performance Among Patients with Each DomainConclusion:This systematic literature review revealed wide variability in the diagnostic estimates of currently available questionnaire-based screening instruments for identifying PsA among psoriasis patients, depending on study populations and disease phenotypes. There is an unmet need for a screening instrument with a better performance in all disease domains.Table 1.Diagnostic estimates of screening tools in different studiesInstrumentNumber of studiesSensitivity%Specificity%PPV%NPV%PASE1824-9138-9518-8813-96PEST1140 – 8537.2-98.623-9647.1-99.3EARP941-97.234-97.214-93.357.5-100TOPAS641-89.129.7-9025.7-91.868-81.6TOPAS-II444-95.880.5-9863.4-95.891-98PsA-Disk questionnaire187.246.458.678.5CONTEST270-76.556.5-9116-8968-95STRIPP191.593.379.697.5SiPAS179877390PASQ267-92.764-81.84383GEPARD277706680Swedish- Psoriasis Assessment Questionnaire163724585PAQ160622687.5SiPAT169699169A novel, short, and simple screening questionnaire186.971.35393.6PASE: Psoriatic Arthritis Screening and Evaluation, PEST: Psoriasis Epidemiology Screening Tool, EARP: Early Arthritis for Psoriatic Patients questionnaire, TOPAS: Toronto Psoriatic Arthritis Screening Questionnaire, STRIPP: Screening Tool for Rheumatologic Investigation,SIPAS: Simple Psoriatic Arthritis Screening questionnaire, PASQ: Psoriasis and Arthritis Screening Questionnaire, GEPARD: German Psoriatic Arthritis Diagnostic Questionnaire, PAQ: Psoriatic and Arthritic Questionnaire, SiPAT: Siriraj Psoriatic Arthritis Screening ToolDisclosure of Interests:None declared.
- Published
- 2021
42. Topical sirolimus for the treatment of angiofibromas in tuberous sclerosis
- Author
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Ayşe Kaçar Bayram, Ayten Ferahbaş, Demet Kartal, Salih Levent Çinar, Murat Borlu, Hüseyin Per, and Mehmet Canpolat
- Subjects
Male ,medicine.medical_specialty ,Administration, Topical ,Dermatology ,tuberous sclerosis ,Angiofibroma ,Vaseline ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Tuberous sclerosis ,0302 clinical medicine ,medicine ,lcsh:Dermatology ,Humans ,Single-Blind Method ,Angiofibromas ,Prospective Studies ,Prospective cohort study ,Child ,Sirolimus ,Antibiotics, Antineoplastic ,Cross-Over Studies ,topical sirolimus ,business.industry ,lcsh:RL1-803 ,medicine.disease ,Surgery ,Infectious Diseases ,Treatment Outcome ,Tolerability ,Itching ,Topical Sirolimus ,Female ,medicine.symptom ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Background: The skin is one of the most affected organs in tuberous sclerosis complex and angiofibromas are seen in almost 80% of such patients. These benign tumors impose a great psycho-social burden on patients. Objective: The aim of the study was to evaluate the effectiveness and tolerability of topical sirolimus for facial angiofibromas in patients with tuberous sclerosis complex. Methods: This was a prospective, single-blinded, cross-over study which involved twelve patients. We investigated the effect and safety of topical 0.1 % sirolimus, which was obtained by crushing sirolimus tablets and mixing it with petrolatum. The patients were asked to apply the cream to one side of their face, and vaseline to the other side. The effect of topical sirolimus was evaluated using the "facial angiofibroma severity index." Results: There was a significant improvement in the redness and extension of the tumors on the sides to which the active ingredient was applied. Some side effects such as itching and irritation occurred in three patients, which were treated with topical hydrocortisone cream. Conclusion: Topical sirolimus appears to be a promising, fairly well tolerated treatment for facial angiofibromas in patients with tuberous sclerosis complex. Although its efficacy diminishes with time, repetitive usage is effective.
- Published
- 2017
43. Definition of videodermoscopic features of demodicosis
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Özlem Karadağ Köse and Murat Borlu
- Subjects
Adult ,Male ,medicine.medical_specialty ,Mite Infestations ,Biopsy ,Dermoscopy ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Skin surface ,Demodicosis ,Medicine ,Animals ,Humans ,Skin pathology ,Acaricides ,Aged ,Skin ,Microscopy ,Mites ,biology ,business.industry ,Middle Aged ,medicine.disease ,biology.organism_classification ,030220 oncology & carcinogenesis ,Clinical diagnosis ,Face ,Demodex mites ,Feasibility Studies ,Female ,business ,Demodex - Abstract
Background Diagnosis of demodicosis is usually confirmed by standardized skin surface biopsy. The skin of the patients with demodicosis is usually very sensitive. There is a need for new noninvasive tests. Videodermoscopic findings of demodicosis have not been validated yet. Our aim was to provide a noninvasive and easy method for diagnosis of demodicosis by using videodermoscopy. Materials and methods This study included 26 patients with demodicosis which were confirmed with microscopy and responded well to anti-Demodex therapy Twenty-six age- and sex-matched individuals without demodicosis constituted the control group. Dermatologic evaluation included clinical observation along with microscopy. All photographs of the clinical and dermoscopic findings were taken with videodermoscope. Results Demodex tails representing "Demodex mites" were a common feature in all patients. Gray dots were described as the second major videodermoscopic finding. Epidermal scale and red dots were also observed with higher prevalence than the other videodermoscopic features. We defined a new finding as follicular annular pigmentation corresponding to the facial pigmentation with demodicosis by videodermoscopy. Conclusions We concluded that it seems possible to confirm the clinical diagnosis of demodicosis by videodermoscopy, with similar results to handheld dermoscopy. Demodex tails should be considered as a sign of demodicosis, whereas detection of gray dots, epidermal scale, and red dots may raise the suspicion of demodicosis.
- Published
- 2018
44. Hair Shaft Disorders
- Author
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Murat Borlu and Salih Levent Cinar
- Published
- 2018
45. Dariers Disease: Two Familial Case Reports
- Author
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Selda Seçkin, Emine Çölgeçen, Murat Borlu, and Sevinç Şahin
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Familial case ,medicine.medical_specialty ,business.industry ,lcsh:R ,Darier's disease ,medicine ,Keratotic papules ,Keratosis follicularis ,lcsh:Medicine ,medicine.disease ,business ,Dermatology - Abstract
DOI: 10.4328/JCAM.3881 Received: 15.09.2015 Accepted: 19.10.2015 Publihed Online: 20.10.2015 Corresponding Author: Emine Colgecen, Department of Dermatology, Bozok University Medical Faculty, 66200, Yozgat, Turkey. T.: +90 3542127060 F.: +90 3542177150 E-Mail: drecolgecen@hotmail.com Ozet Darier hastaligi (Darier-White hastaligi, keratozis follikularis), ozellikle seboreik bolgeleri tutan, keratinizasyon bozuklugu ile karakterize, otozomal dominant gecisli, nadir gozlenen bir hastaliktir. Bu makalede, klinik ve histopatolojik bulgular ile Darier’s disease tanisi konulan 47 ve 28 yaslarinda ki anne ve kiz iki kadin hasta, bu hastaligin nadir gorulmesi nedeniyle sunulmustur.
- Published
- 2016
46. The skin findings of pregnant women and our treatment choices. A Turkish experience: a 5-year survey
- Author
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Murat Borlu, Demet Kartal, Semih Uludag, Salih Levent Çinar, Atıl Avcı, Ragıp Ertaş, and Mehmet Dolanbay
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Pregnancy ,medicine.medical_specialty ,Turkish ,business.industry ,Treatment choices ,medicine.disease ,language.human_language ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Family medicine ,medicine ,language ,Outpatient clinic ,030212 general & internal medicine ,business ,Psychiatry ,Skin Findings - Abstract
Uzm. Dr. Salih Levent Cinar, Erciyes Universitesi Tip Fakultesi, Deri ve Zuhrevi Hastaliklar Anabilim Dali, Talas 38039 Kayseri Turkiye, Tel. 0505 240 61 25 Email. sleventcinar@yahoo.com Gelis Tarihi: 28.09.2015 • Kabul Tarihi: 06.11.2015 ABSTRACT AIM: The number of pregnant women applying to dermatology outpatient clinics has increased. This has brought to notice the need for a specialized approach. In order to deal with pregnant women and their diseases, one must have a good knowledge of the skin disorders of pregnancy. Pregnant women and women who are considering pregnancy should be treated exclusively.
- Published
- 2016
47. Is idiopathic hirsutism (IH) really idiopathic? mRNA expressions of skin steroidogenic enzymes in women with IH
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Zuleyha Karaca, Fahrettin Kelestimur, Munis Dundar, Fatih Tanriverdi, Gokmen Zararsiz, Mahmut Tuncay Ozgun, Serpil Taheri, Murat Borlu, Kursad Unluhizarci, and Sulbiye Karaburgu
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Adult ,Hirsutism ,medicine.medical_specialty ,Adolescent ,medicine.drug_class ,Endocrinology, Diabetes and Metabolism ,urologic and male genital diseases ,Estradiol Dehydrogenases ,Young Adult ,Endocrinology ,Internal medicine ,Abdomen ,Humans ,Medicine ,RNA, Messenger ,Aromatase ,hirsutism ,Skin ,biology ,medicine.diagnostic_test ,Interleukin-6 ,business.industry ,General Medicine ,Androgen ,medicine.disease ,SRD5A1 ,CYP17A1 ,Case-Control Studies ,SRD5A2 ,Skin biopsy ,Androgens ,Arm ,biology.protein ,HSD3B2 ,Female ,Steryl-Sulfatase ,business - Abstract
ObjectiveHirsutism results from hyperandrogenemia and/or exaggerated androgen responsiveness. Among various causes of hirsutism, some patients do not exhibit androgen excess which is called idiopathic hirsutism (IH). The pathogenesis of IH could not so far be clearly established.DesignTo investigate the mRNA expression of aromatase enzyme and the other enzymes having functional roles in the steroidogenic pathway, in freshly obtained skin tissue from subumbilical skin and the arm of the patients with IH and healthy women.MethodsTwenty-one women with IH and 15 healthy women were included in the study. We aimed to determine mRNA expressions of genes associated with local androgen synthesis and metabolism (CYP11A1, STS, CYP19A1, SRD5A1, SRD5A2, HSD3B1, AR, COMT, ESR1, ESR2, HSD3B2, CYP17A1, SULT2A1, SULT1E1, HSD17B2, IL6, TGFB1, TNFA) from skin biopsy and blood samples of patients with IH and the data compared with healthy subjects.ResultsPatients with IH exhibit significantly lower interleukin 6 (IL6) mRNA expression and higher steroid sulphatase (STS) and hydroxysteroid (17beta) dehydrogenase 2 (HSD17B2), gene mRNA expression, respectively, in the subumbilical region skin biopsies. Similarly, patients with IH exhibit significantly lowerIL6mRNA expression and higherSTSandHSD17B2gene mRNA expression, respectively, in the arm skin compared to healthy women's subumbilical region.ConclusionsIn both arm and subumbilical skin biopsy of patients with IH, we observed an up-regulation ofHSD17B2andSTS, decreasedIL6mRNA expression, probably determining an increase in the local amount of active androgens, which could then be used as substrate for other androgen metabolic routes.
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- 2015
48. Nail fold capillary abnormality and insulin resistance in children with familial Mediterranean fever: is there any relationship between vascular changes and insulin resistance?
- Author
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Demet Kartal, Murat Borlu, Ahmet B. Cekgeloglu, Mehmet E. Yuksel, Sibel Yel, Hakan Poyrazoglu, Zübeyde Gündüz, Ruhan Düşünsel, Sebahat Tulpar, Kamil Cagri Kose, Abdullah Caliskan, Ismail Dursun, and Funda Bastug
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030203 arthritis & rheumatology ,0301 basic medicine ,medicine.medical_specialty ,integumentary system ,business.industry ,Familial Mediterranean fever ,medicine.disease ,Nail fold ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Insulin resistance ,Endocrinology ,Internal medicine ,medicine ,Abnormality ,skin and connective tissue diseases ,business - Abstract
Objective: Nail fold capillary changes are accepted as early symptoms of several rheumatic disorders such as scleroderma and dermatomyositis. In adults, nail fold capillary abnormality (NCA) has been described in Familial Mediterranean Fever (FMF). However, there is not enough study in children with FMF. The aim of the present study was (1) to investigate whether children with FMF have NCA in both active and/or remission period or not and (2) to assess insulin resistance in children with FMF in both active and/or remission period of the disease compared with the control group.
- Published
- 2018
49. The Turkish guideline for the diagnosis and management of atopic dermatitis-2018
- Author
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Murat Borlu, Özlem Küçük, Ayşe Serap Karadağ, Ilgen Ertam Sağduyu, Hayriye Saricaoğlu, Evren Odyakmaz Demirsoy, Sibel Alper, Ege Üniversitesi, and KÜÇÜK, Özlem Su
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medicine.medical_specialty ,algorithm ,treatment ,Turkey ,Turkish ,business.industry ,diagnosis ,Ertam I., Su Ö. S. , Alper S., Saricaoglu H., KARADAĞ A. S. , Demirsoy E. O. , BORLU M., -The Turkish guideline for the diagnosis and management of atopic dermatitis-2018-, TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY, cilt.52, ss.6-23, 2018 ,Dermatology ,Atopic dermatitis ,Guideline ,lcsh:RL1-803 ,lcsh:Diseases of the genitourinary system. Urology ,lcsh:RC870-923 ,medicine.disease ,language.human_language ,lcsh:Dermatology ,medicine ,language ,business ,guideline - Abstract
WOS: 000435797400003, Background and Design: Atopic dermatitis (AD) has a complicated etiopathogenesis and difficulties in diagnosis and treatment from time to time. Because of the disease which different approaches can be seen rationalize the need for an algorithm for the diagnosis, classification, etiopathogenesis, diagnostic tests and therapeutic approach. Therefore, authors from Dermatoallergy Working Group of the Turkish Society of Dermatology aimed to create an AD guideline for the diagnosis, treatment and followup. Materials and Methods: Each section of the guideline has been written by a different author. The prepared sections were evaluated in part by e-mail correspondence and have taken its final form after revision in the last meeting held by the participation of all authors. Results: The guideline includes the diagnosis, classification, etiopathogenesis, diagnostic tests and therapeutic approach of AD. Lesions show age-related morphology and distribution. There are no in vivo/in vitro tests that have high sensitivity and specificity that can be used to identify AD and trigger factors. The first step of treatment consists of moisturizers, topical corticosteroids and calcineurin inhibitors, respectively. Moisturizers are used therapeutically in all forms of AD. Topical corticosteroids are the first agents to be used when moisturizers are inadequate. Topical calcineurin inhibitors should be used in lesions resistant to corticosteroids, for proactive treatment, special areas. Antimicrobials agents and antiseptics should only be added to treatment when clinical signs of infection are present. And in topical treatment-resistant cases, second-line treatment is phototherapy or oral cyclosporine. The biologic agent, dupilumab, is promising in the treatment of severe AD. Conclusion: AD is a disease that can be challenging for the physician in terms of treatment and follow-up. Depending on evidence-based data (and individual experiences), this guideline will have a leading role in the diagnosis and treatment of AD and help the physician to overcome the challenges in the management.
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- 2018
50. Clinical practice guidelines for the diagnosis and treatment of cutaneous leishmaniasis in Turkey
- Author
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Melih Akyol, Yelda Kapicioglu, Yavuz Yesilova, Mehmet Salih Gürel, Murat Borlu, Yusuf Özbel, Ayşe Akman-Karakaş, Bilge Fettahlıoğlu Karaman, Mehmet Harman, Tamer Irfan Kaya, Soner Uzun, Seray Töz, Çiğdem Asena Doğramacı, Mustafa Aksoy, Sema Aytekin, Murat Durdu, Orhan Ozgoztasi, Mehmet Kamil Mülayim, Esra İnan Doğan, Çukurova Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Karaman, Bilge Fettahlıoğlu, [Uzun, Soner -- Akman-Karakas, Ayse] Akdeniz Univ, Dept Dermatol, Fac Med, TR-07059 Antalya, Turkey -- [Gurel, Mehmet S.] Medeniyet Univ, Dept Dermatol, Fac Med, Istanbul, Turkey -- [Durdu, Murat] Baskent Univ, Dept Dermatol, Fac Med, Adana, Turkey -- [Akyol, Melih] Cumhuriyet Univ, Dept Dermatol, Fac Med, Sivas, Turkey -- [Karaman, Bilge Fettahlioglu] Cukurova Univ, Dept Dermatol, Fac Med, Adana, Turkey -- [Aksoy, Mustafa] Harran Univ, Dept Dermatol, Fac Med, Sanliurfa, Turkey -- [Aytekin, Sema] Haydarpasa Numune Training & Res Hosp, Dept Dermatol, Istanbul, Turkey -- [Borlu, Murat] Erciyes Univ, Dept Dermatol, Fac Med, Kayseri, Turkey -- [Dogan, Esra Inan] Adiyaman Univ, Dept Dermatol, Fac Med, Adiyaman, Turkey -- [Dogramaci, Cigdem Asena] Mustafa Kemal Univ, Dept Dermatol, Fac Med, Antakya, Turkey -- [Kapicioglu, Yelda] Inonu Univ, Dept Dermatol, Fac Med, Malatya, Turkey -- [Kaya, Tamer I.] Mersin Univ, Dept Dermatol, Fac Med, Mersin, Turkey -- [Mulayim, Mehmet K.] Sutcu Imam Univ, Dept Dermatol, Fac Med, Kahramanmaras, Turkey -- [Ozbel, Yusuf -- Toz, Seray Ozensoy] Ege Univ, Dept Parasitol, Fac Med, Izmir, Turkey -- [Ozgoztasi, Orhan] Gaziantep Univ, Dept Dermatol, Fac Med, Gaziantep, Turkey -- [Yesilova, Yavuz] Lokman Hekim Hosp, Dept Dermatol, Van, Turkey -- [Harman, Mehmet] Dicle Univ, Dept Dermatol, Fac Med, Diyarbakir, Turkey, uzun, soner -- 0000-0001-7059-5474, Durdu, Murat -- 0000-0003-1247-3932, and Çukurova Üniversitesi
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Antimony ,medicine.medical_specialty ,Delphi Technique ,Turkey ,FEATURES ,030231 tropical medicine ,MEDLINE ,Antiprotozoal Agents ,Leishmaniasis, Cutaneous ,MEGLUMINE ANTIMONIATE ,Dermatology ,Disease ,Diagnosis, Differential ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,DONOVANI ,Cutaneous leishmaniasis ,Amphotericin B ,medicine ,Organometallic Compounds ,Humans ,Intensive care medicine ,Evidence-Based Medicine ,business.industry ,Incidence (epidemiology) ,Leishmaniasis ,Guideline ,Evidence-based medicine ,EFFICACY ,medicine.disease ,Cryotherapy ,Parasitic disease ,Practice Guidelines as Topic ,INTRALESIONAL SODIUM STIBOGLUCONATE ,TRIAL ,business ,SANLIURFA ,Algorithms - Abstract
WOS: 000437833900024, PubMed ID: 29663351, Background Cutaneous leishmaniasis ( CL) is a vector- born parasitic disease characterized by various skin lesions that cause disfiguration if healed spontaneously. Although CL has been endemic for many years in the southern regions of Turkey, an increasing incidence in nonendemic regions is being observed due to returning travelers and, more recently, due to Syrian refugees. Thus far, a limited number of national guidelines have been proposed, but no common Turkish consensus has emerged. Objectives The aim of this study was to develop diagnostic and therapeutic guidelines for the management of CL in Turkey. Methods This guideline is a consensus text prepared by 18 experienced CL specialists who have been working for many years in areas where the disease is endemic. The Delphi method was used to determine expert group consensus. Initially, a comprehensive list of items about CL was identified, and consensus was built from feedback provided by expert participants from the preceding rounds. Results Evidence- based and expert- based recommendations through diagnostic and therapeutic algorithms according to local availability and conditions are outlined. Conclusion Because CL can mimic many other skin diseases, early diagnosis and early treatment are very important to prevent complications and spread of the disease. The fastest and easiest diagnostic method is the leishmanial smear. The most common treatment is the use of local or systemic pentavalent antimony compounds.
- Published
- 2017
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