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Your search keyword '"Murashkina, Arina V."' showing total 13 results
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13 results on '"Murashkina, Arina V."'

1. Base-Catalyzed Reaction of Isatins and (3-Hydroxyprop-1-yn-1-yl)phosphonates as a Tool for the Synthesis of Spiro-1,3-dioxolane Oxindoles with Anticancer and Anti-Platelet Properties.

Author

Murashkina, Arina V., Bogdanov, Andrei V., Voloshina, Alexandra D., Lyubina, Anna P., Samorodov, Alexandr V., Mitrofanov, Alexander Y., Beletskaya, Irina P., Smolyarchuk, Elena A., Zavadich, Kseniya A., Valiullina, Zulfiya A., Nazmieva, Kseniya A., Korunas, Vladislav I., and Krylova, Irina D.

Subjects
*SPIRO compounds, *ASPIRIN, *CYTOTOXINS, *PHOSPHONATES, *ISATIN
Abstract

An approach to the synthesis of phosphoryl substituted spiro-1,3-dioxolane oxindoles was developed from the base-catalyzed reaction of various isatins with (3-hydroxyprop-1-yn-1-yl)phosphonates. It was found that various aryl-substituted and N-functionalized isatins with the formation of appropriate products with high yields and stereoselectivity when using t-BuOLi are able to react. Cytotoxic activity evaluation suggests that the most significant results in relation to the HuTu 80 cell line were shown by N-benzylated spirodioxolanes. 5-Cloro-N-unsubstituted spirooxindoles exhibit antiaggregational activity exceeding the values of acetylsalicylic acid. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Formation of C–C, C–S and C–N bonds catalysed by supported copper nanoparticles

Author

Universidad de Alicante. Departamento de Química Orgánica, Universidad de Alicante. Instituto Universitario de Síntesis Orgánica, Mitrofanov, Alexander Yu., Murashkina, Arina V., Martín-García, Iris, Alonso, Francisco, Beletskaya, Irina P., Universidad de Alicante. Departamento de Química Orgánica, Universidad de Alicante. Instituto Universitario de Síntesis Orgánica, Mitrofanov, Alexander Yu., Murashkina, Arina V., Martín-García, Iris, Alonso, Francisco, and Beletskaya, Irina P.

Abstract

Transition-metal catalysed cross-coupling reactions are still dominated by palladium chemistry. Within the recent past, copper has gained ground against palladium by virtue of its cheaper price and equivalent function in certain reactions. Four catalysts consisting of copper nanoparticles on zeolite, titania, montmorillonite and activated carbon have been tested in three palladium- and ligand-free cross-coupling reactions to form carbon–carbon, carbon–sulfur and carbon–nitrogen bonds. CuNPs/zeolite has been found to be the best one in the Sonogashira reaction of aryl iodides and arylacetylenes, as well as in the coupling of aryl halides with aryl and alkyl thiols, being reusable in both cases. However, the arylation of nitrogen-containing heterocycles (imidazole, pyrazole, benzimidazole and indole) has been better accomplished with CuNPs/titania, albeit CuNPs/activated carbon showed better recycling properties. The catalytic activity of the nanostructured catalysts has been compared with that of twelve commercial copper catalysts, with the former outperforming the latter in the three types of reactions studied.

Published
2017

13. Switchable Selectivity in the Annulation of o-Trifluoroacetylanilines and Activated Terminal Alkynes Based on Transition Metal and Phosphine Catalysis.

Author

Mitrofanov AY, Murashkina AV, Lyssenko KA, and Beletskaya IP

Abstract

In this work, we have developed selective methods for the synthesis of quinoline-2-carboxylates and quinoline-3-carboxylates as well as (indolin-2-ylidene)acetates through copper-, silver-, or phosphine-catalyzed reaction of propiolates with 2'-amino-2,2,2-trifluoroacetophenones. The approaches proposed ensure synthesis of substituted quinoline carboxylates and (indolin-2-ylidene)acetates in good yields. Introduction of alkynones into the reaction with 2'-amino-2,2,2-trifluoroacetophenones gives acyl substituted derivatives in good yields., (© 2023 Wiley-VCH GmbH.)

Published
2023
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