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1. Analysis of the resistance frame of the equipment for opening and compartmentalizing watering furrows, using 3D finite elements

Author

Cardei Petru, Oprescu Marius, Constantin Nicolae, Biriș Ștefan-Sorin, and Muraru Sebastian

Subjects
Environmental sciences, GE1-350
Abstract

The proposed article sets out the results of the finite element structural analysis for the open and compartmentalised watering furrow equipment (OCWFE). It uses a 3D structural model with 3D finite elements. The analysis set out in the article is made in order to determine the field of relative displacement and equivalent stress in the load-bearing structure of the OCWFE. The structural model is generated in CAD-CAM. For the structural analysis, it is necessary the CAE model, which is obtained from the CAD-CAM model, mainly by eliminating gaps and interferences, but also by the techniques of realizing the contact between the components of the assembly and a careful mashing of the structure. The structural model thus created is supported and loaded in accordance with the experimental results from the literature. The relative displacement field and the equivalent stress field within the resistance frame of the OCWFE is obtained following the linear static analysis. The field of relative displacements is used to assess the effects on the quality of the work performed. The equivalent stress field is used to estimate the safety factor of the structure, by reference to the flow stress of the material from which the structure is built.

Published
2021
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2. Considerations on the importance of the main chemical properties of the soil in agrochemical studies

Author

Muraru Sebastian, Muraru Vergil, Condruz Paula, Ionel Cornelia Muraru, and Sfiru Raluca

Subjects
Environmental sciences, GE1-350
Abstract

Information on soil nutrition level or soil pollution level can lead to the establishment of some recommendations or a strategic decision-making program for the reference area development. The specific soil analysis is essential both from an economic point of view and from an environmental point of view. To achieve an adequate management of the nutrients into an agricultural field, it is necessary to conduct an agrochemical study at an interval of 3–5 years, in which, the relevant agrochemical indicators for the evaluation of the nutrient supply state must be analysed, to determine fertilizer doses and/or recommended amendments for the expected crops. The agrochemical study must contain the analysis bulletin that provides the following information: pH value, humus and total nitrogen content, phosphorus (P) and potassium (K) content, C/N ratio (carbon / nitrogen), nitrogen index (NI), as well as the main microelements.

Published
2021
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3. Mathematical modelling and numerical simulation of linear electro-hydraulic servomechanism with stepper motor

Author

Muraru Vergil, Calinoiu Constantin, Muraru Sebastian, Dulgheru Ana, and Muraru-Ionel Cornelia

Subjects
Environmental sciences, GE1-350
Abstract

The paper presents the results of research on the performance of linear electro-hydraulic servomechanisms with stepper motor, evaluated by mathematical modelling and numerical simulation with the AMESIM software package. These servomechanisms have a great potential for application, including for agricultural technical equipment. Servomechanisms of various types are used for the rapid and high precision operation of the various systems. In practice, electro-hydraulic servomechanisms have been required in the case of the systems requiring high forces or moments. These equipment are automatic hydraulic tracking systems and can be analysed with methods specific to automatic systems. The paper contains a structural description of an electro-mechanical servomechanism with stepper motor, its operation, mathematical model and its performances obtained by numerical simulation. The mathematical modelling of the electro-hydraulic servomechanism is based on the relations between the input sizes and output sizes of the equipment in its structure as well as the connection relations between these equipment. Based on the obtained results it is demonstrated that the analysis and synthesis of electro-hydraulic servomechanisms with stepper motor can be determined by numerical simulation using the AMESIM simulation software.

Published
2020
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4. Soil moisture influence in the soil tillage operations

Author

Cardei Petru, Sfiru Raluca, Muraru Sebastian, and Condruz Paula

Subjects
Environmental sciences, GE1-350
Abstract

This article presents results obtained by the author in an attempt to introduce new parameters that influence the working process of agricultural soil working machines, in the classical formulas that mathematically model the tillage draft force. This article naturally introduces soil moisture. To introduce soil moisture into the calculation formulas of the tillage draft force, other physical parameters affected by soil moisture were used: density, cohesion, adhesion, etc. In this article, is explicitly describes, only the variation of soil density with its moisture. Considering some phenomena such as soil swelling or shrinkage, required the development of an adequate mathematical model of the expression of the density of soil-water mixture, concerning the concentration of water and the densities of dry soil and water. The final formulas obtained are tested to experimental results from the literature. Finally, the author sets out his opinion regarding the use of the results in design calculations and regarding the elevation to the rank of physical law of a mathematical model represented by a formula with a large number of parameters, which in turn are still dependent on many others parameters.

Published
2020
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5. Drones and windbreaks

Author

Cardei Petru, Muraru Sebastian, and Matache Mihai

Subjects
Environmental sciences, GE1-350
Abstract

The article presents a possibility of applying the techniques specific to the drones (UAV) in order to estimate the efficiency, and optimize the windbreaks (vegetative barriers, forest curtains).In the first part the article presents a variant of determination of the dynamic and optical porosities of forest protection curtains using one or two drones simultaneously. In the second part, ascertaining some language inaccuracies, it observes that the issue of the efficiency of the forest curtains became a problem of mitigation of wind intensity. Finally, the last proposed application shows that using the drones, you can estimate the protected volumes behind the curtains, basically giving up the optical porosity. In order to achieve these applications, there is an essential condition: records of the magnitude of the wind speed and of the coordinates must not be excessively affected by the wind.

Published
2019
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9. An approach to the proposal of drug combination for cancer therapy using a pathway data connectivity approach

Author

Miller, Ryan, Muraru, Sebastian, Malpartida, Ana Belen, Low, Josh, de Almeida, Mariana Pelicano, van Engelen, Bo, Godynyuk, Elizabeth, Abecassis, Barbara Schmitz, Willighagen, Egon, Evelo, Chris, Rieswijk, Linda, RS: CAPHRI - R5 - Optimising Patient Care, Family Medicine, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, Bioinformatica, Dept. of Advanced Computing Sciences, and Institute of Data Science

Abstract

Within the next twenty years, the number of cancer patients is expected to rise by 70%. Current cancer treatments still face several limitations, such as severe side effects and a high incidence of disease recurrence. Drug combination therapies are a promising strategy to achieve higher therapeutic effects while reducing side effects. This new direction in cancer drug research has led to data-driven medicine. To predict whether certain drugs would have a synergistic effect when combined, the DREAM Challenge coordinators released data for thousands of experimentally tested drug combinations. The DREAM Challenge served as inspiration for selecting drug combinations that have the potential to be synergistic. We here describe an approach using biological pathway knowledge and applying this to the selected combinations with a previously described mathematical model, the Loewe-Additivity approach. The calculated interaction index (II) served to distinguish between synergistic (II < 1), additive (II = 1) and antagonistic (II > 1). Pre-selection of putative drug combinations was performed prior to synergy prediction based on four case scenarios: 1) two drugs share the same target protein, 2) two drugs share the same pathway, 3) drugs are separated by one degree from two targets or 4) drugs are separated by more than one degree from two targets but act upon the same biological pathway. Results: The first method tried was using a drug synergy prediction method called the Loewe-Additivity model, in which two drugs share the same target and form the initial findings for this paper. The Loewe model acts as a baseline estimation to see if more combinations can be identified using the other methods tested. The remaining methods used were able to find additional drug combinations that were not proposed by the standard Loewe model. Although the additional methods did find additional combinations that would be predicted to be synergistic, a prediction is not a guarantee of success, so validation of the new or novel combinations would be needed to verify their effectiveness. This could be done by comparing our results to known data or against biological assays.

Published
2022

10. An approach to the proposal of drug combination for cancer therapy using a pathway data connectivity approach

Author

Miller, Ryan, primary, Muraru, Sebastian, additional, Belén Malpartida, Ana, additional, Low, Josh, additional, Pelicano de Almeida, Mariana, additional, van Engelen, Bo, additional, Godynyuk, Elizabeth, additional, Schmitz-Abecassis, Bárbara, additional, Willighagen, Egon, additional, Evelo, Chris, additional, and Rieswijk, Linda, additional

Published
2022
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12. PERIODIC DRAFT TILLAGE FORCES IN SOIL WORKING PROCESSES OF AGRICULTURAL EQUIPMENT

Author

Oprescu Remus Marius, Muraru-Ionel Cornelia, Muraru Vergil, Muraru Sebastian, and Cardei Petru

Subjects
Tillage, Agricultural machinery, business.industry, Environmental science, Agricultural engineering, business
Abstract

The article presents results of the mathematical modelling of the tensile strength for equipment for opening and compartmentalizing watering furrows. This agricultural machine develops a less common traction force, with two components, one of which with oscillates behavior. The mathematical model given in the paper provides calculation formulas for the static component and for the dynamic component. Model constants are used to calibrate the model using existing experimental data for this type of machine. The paper it is specified the dynamics problems of agricultural machines in which such models are needed

Published
2021
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14. Soil Spectral Analysis

Author

Muraru, Sebastian-Lucian, primary, Muraru, Vergil, additional, Condruz, Paula, additional, Muraru-Ionel, Cornelia, additional, and Sfiru, Raluca, additional

Published
2021
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28. Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Author

Menden, Michael P., Wang, Dennis, Mason, Mike J., Szalai, Bence, Bulusu, Krishna C., Guan, Yuanfang, Yu, Thomas, Kang, Jaewoo, Jeon, Minji, Wolfinger, Russ, Nguyen, Tin, Zaslavskiy, Mikhail, Jang, In Sock, Ghazoui, Zara, Ahsen, Mehmet Eren, Vogel, Robert, Neto, Elias Chaibub, Norman, Thea, Tang, Eric K. Y., Garnett, Mathew J., Di Veroli, Giovanni Y., Fawell, Stephen, Stolovitzky, Gustavo, Guinney, Justin, Dry, Jonathan R., Saez-Rodriguez, Julio, Abante, Jordi, Abecassis, Barbara Schmitz, Aben, Nanne, Aghamirzaie, Delasa, Aittokallio, Tero, Akhtari, Farida S., Al-lazikani, Bissan, Alam, Tanvir, Allam, Amin, Allen, Chad, de Almeida, Mariana Pelicano, Altarawy, Doaa, Alves, Vinicius, Amadoz, Alicia, Anchang, Benedict, Antolin, Albert A., Ash, Jeremy R., Romeo Aznar, Victoria, Ba-alawi, Wail, Bagheri, Moeen, Bajic, Vladimir, Ball, Gordon, Ballester, Pedro J., Baptista, Delora, Bare, Christopher, Bateson, Mathilde, Bender, Andreas, Bertrand, Denis, Wijayawardena, Bhagya, Boroevich, Keith A., Bosdriesz, Evert, Bougouffa, Salim, Bounova, Gergana, Brouwer, Thomas, Bryant, Barbara, Calaza, Manuel, Calderone, Alberto, Calza, Stefano, Capuzzi, Stephen, Carbonell-Caballero, Jose, Carlin, Daniel, Carter, Hannah, Castagnoli, Luisa, Celebi, Remzi, Cesareni, Gianni, Chang, Hyeokyoon, Chen, Guocai, Chen, Haoran, Chen, Huiyuan, Cheng, Lijun, Chernomoretz, Ariel, Chicco, Davide, Cho, Kwang-Hyun, Cho, Sunghwan, Choi, Daeseon, Choi, Jaejoon, Choi, Kwanghun, Choi, Minsoo, De Cock, Martine, Coker, Elizabeth, Cortes-Ciriano, Isidro, Cserzo, Miklos, Cubuk, Cankut, Curtis, Christina, Van Daele, Dries, Dang, Cuong C., Dijkstra, Tjeerd, Dopazo, Joaquin, Draghici, Sorin, Drosou, Anastasios, Dumontier, Michel, Ehrhart, Friederike, Eid, Fatma-Elzahraa, ElHefnawi, Mahmoud, Elmarakeby, Haitham A., van Engelen, Bo, Engin, Hatice Billur, de Esch, Iwan, Evelo, Chris, Falcao, Andre O., Farag, Sherif, Fernandez-Lozano, Carlos, Fisch, Kathleen, Flobak, Asmund, Fornari, Chiara, Foroushani, Amir B. K., Fotso, Donatien Chedom, Fourches, Denis, Friend, Stephen, Frigessi, Arnoldo, Gao, Feng, Gao, Xiaoting, Gerold, Jeffrey M., Gestraud, Pierre, Ghosh, Samik, Gillberg, Jussi, Godoy-Lorite, Antonia, Godynyuk, Lizzy, Godzik, Adam, Goldenberg, Anna, Gomez-Cabrero, David, Gonen, Mehmet, de Graaf, Chris, Gray, Harry, Grechkin, Maxim, Guimera, Roger, Guney, Emre, Haibe-Kains, Benjamin, Han, Younghyun, Hase, Takeshi, He, Di, He, Liye, Heath, Lenwood S., Hellton, Kristoffer H., Helmer-Citterich, Manuela, Hidalgo, Marta R., Hidru, Daniel, Hill, Steven M., Hochreiter, Sepp, Hong, Seungpyo, Hovig, Eivind, Hsueh, Ya-Chih, Hu, Zhiyuan, Huang, Justin K., Huang, R. Stephanie, Hunyady, Laszlo, Hwang, Jinseub, Hwang, Tae Hyun, Hwang, Woochang, Hwang, Yongdeuk, Isayev, Olexandr, Walk, Oliver Bear Don't, Jack, John, Jahandideh, Samad, Ji, Jiadong, Jo, Yousang, Kamola, Piotr J., Kanev, Georgi K., Karacosta, Loukia, Karimi, Mostafa, Kaski, Samuel, Kazanov, Marat, Khamis, Abdullah M., Khan, Suleiman Ali, Kiani, Narsis A., Kim, Allen, Kim, Jinhan, Kim, Juntae, Kim, Kiseong, Kim, Kyung, Kim, Sunkyu, Kim, Yongsoo, Kim, Yunseong, Kirk, Paul D. W., Kitano, Hiroaki, Klambauer, Gunter, Knowles, David, Ko, Melissa, Kohn-Luque, Alvaro, Kooistra, Albert J., Kuenemann, Melaine A., Kuiper, Martin, Kurz, Christoph, Kwon, Mijin, van Laarhoven, Twan, Laegreid, Astrid, Lederer, Simone, Lee, Heewon, Lee, Jeon, Lee, Yun Woo, Leppaho, Eemeli, Lewis, Richard, Li, Jing, Li, Lang, Liley, James, Lim, Weng Khong, Lin, Chieh, Liu, Yiyi, Lopez, Yosvany, Low, Joshua, Lysenko, Artem, Machado, Daniel, Madhukar, Neel, De Maeyer, Dries, Malpartida, Ana Belen, Mamitsuka, Hiroshi, Marabita, Francesco, Marchal, Kathleen, Marttinen, Pekka, Mason, Daniel, Mazaheri, Alireza, Mehmood, Arfa, Mehreen, Ali, Michaut, Magali, Miller, Ryan A., Mitsopoulos, Costas, Modos, Dezso, Van Moerbeke, Marijke, Moo, Keagan, Motsinger-Reif, Alison, Movva, Rajiv, Muraru, Sebastian, Muratov, Eugene, Mushthofa, Mushthofa, Nagarajan, Niranjan, Nakken, Sigve, Nath, Aritro, Neuvial, Pierre, Newton, Richard, Ning, Zheng, De Niz, Carlos, Oliva, Baldo, Olsen, Catharina, Palmeri, Antonio, Panesar, Bhawan, Papadopoulos, Stavros, Park, Jaesub, Park, Seonyeong, Park, Sungjoon, Pawitan, Yudi, Peluso, Daniele, Pendyala, Sriram, Peng, Jian, Perfetto, Livia, Pirro, Stefano, Plevritis, Sylvia, Politi, Regina, Poon, Hoifung, Porta, Eduard, Prellner, Isak, Preuer, Kristina, Angel Pujana, Miguel, Ramnarine, Ricardo, Reid, John E., Reyal, Fabien, Richardson, Sylvia, Ricketts, Camir, Rieswijk, Linda, Rocha, Miguel, Rodriguez-Gonzalvez, Carmen, Roell, Kyle, Rotroff, Daniel, de Ruiter, Julian R., Rukawa, Ploy, Sadacca, Benjamin, Safikhani, Zhaleh, Safitri, Fita, Sales-Pardo, Marta, Sauer, Sebastian, Schlichting, Moritz, Seoane, Jose A., Serra, Jordi, Shang, Ming-Mei, Sharma, Alok, Sharma, Hari, Shen, Yang, Shiga, Motoki, Shin, Moonshik, Shkedy, Ziv, Shopsowitz, Kevin, Sinai, Sam, Skola, Dylan, Smirnov, Petr, Soerensen, Izel Fourie, Soerensen, Peter, Song, Je-Hoon, Song, Sang Ok, Soufan, Othman, Spitzmueller, Andreas, Steipe, Boris, Suphavilai, Chayaporn, Tamayo, Sergio Pulido, Tamborero, David, Tang, Jing, Tanoli, Zia-ur-Rehman, Tarres-Deulofeu, Marc, Tegner, Jesper, Thommesen, Liv, Tonekaboni, Seyed Ali Madani, Tran, Hong T., De Troyer, Ewoud, Truong, Amy, Tsunoda, Tatsuhiko, Turu, Gabor, Tzeng, Guang-Yo, Verbeke, Lieven, Videla, Santiago, Vis, Daniel, Voronkov, Andrey, Votis, Konstantinos, Wang, Ashley, Wang, Hong-Qiang Horace, Wang, Po-Wei, Wang, Sheng, Wang, Wei, Wang, Xiaochen, Wang, Xin, Wennerberg, Krister, Wernisch, Lorenz, Wessels, Lodewyk, van Westen, Gerard J. P., Westerman, Bart A., White, Simon Richard, Willighagen, Egon, Wurdinger, Tom, Xie, Lei, Xie, Shuilian, Xu, Hua, Yadav, Bhagwan, Yau, Christopher, Yeerna, Huwate, Yin, Jia Wei, Yu, Michael, Yu, MinHwan, Yun, So Jeong, Zakharov, Alexey, Zamichos, Alexandros, Zanin, Massimiliano, Zeng, Li, Zenil, Hector, Zhang, Frederick, Zhang, Pengyue, Zhang, Wei, Zhao, Hongyu, Zhao, Lan, Zheng, Wenjin, Zoufir, Azedine, Zucknick, Manuela, and Computer Science

Subjects
health care economics and organizations
Abstract

The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca's large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells. AstraZeneca European Union Horizon 2020 research [668858 PrECISE] Joint Research Center for Computational Biomedicine (Bayer AG) National Institute for Health Research (NIHR) Sheffield Biomedical Research Center, Premium Postdoctoral Fellowship Program of the Hungarian Academy of Sciences Wellcome Trust [102696, 206194] We thank the Genomics of Drug Sensitivity in Cancer and COSMIC teams at the Wellcome Trust Sanger Institute for help with the preparation of the molecular data, Denes Turei for help with Omnipath, and Katjusa Koler for help with matching drug names across combination screens. We thank AstraZeneca for funding and provision of data to the DREAM Consortium to run the challenge, and funding from the European Union Horizon 2020 research (under grant agreement No 668858 PrECISE to J.S.R.), the Joint Research Center for Computational Biomedicine (which is partially funded by Bayer AG) to J.S.R., National Institute for Health Research (NIHR) Sheffield Biomedical Research Center, Premium Postdoctoral Fellowship Program of the Hungarian Academy of Sciences. M.G lab is supported by Wellcome Trust (102696 and 206194).

Published
2019

29. Considerations on the importance of the main chemical properties of the soil in agrochemical studies.

Author

Muraru, Sebastian, Muraru, Vergil, Condruz, Paula, Ionel, Cornelia Muraru, and Sfiru, Raluca

Subjects
TRACE elements, SOIL testing, INFORMATION retrieval, PH standards, STRATEGIC planning
Abstract

Information on soil nutrition level or soil pollution level can lead to the establishment of some recommendations or a strategic decision-making program for the reference area development. The specific soil analysis is essential both from an economic point of view and from an environmental point of view. To achieve an adequate management of the nutrients into an agricultural field, it is necessary to conduct an agrochemical study at an interval of 3-5 years, in which, the relevant agrochemical indicators for the evaluation of the nutrient supply state must be analysed, to determine fertilizer doses and/or recommended amendments for the expected crops. The agrochemical study must contain the analysis bulletin that provides the following information: pH value, humus and total nitrogen content, phosphorus (P) and potassium (K) content, C/N ratio (carbon / nitrogen), nitrogen index (NI), as well as the main microelements. [ABSTRACT FROM AUTHOR]

Published
2021
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30. Analysis of the resistance frame of the equipment for opening and compartmentalizing watering furrows, using 3D finite elements.

Author

Cardei, Petru, Oprescu, Marius, Constantin, Nicolae, Biriș, Ștefan-Sorin, and Muraru, Sebastian

Subjects
FURROW irrigation, FINITE element method, THREE-dimensional imaging, LATTICE theory, STATICS
Abstract

The proposed article sets out the results of the finite element structural analysis for the open and compartmentalised watering furrow equipment (OCWFE). It uses a 3D structural model with 3D finite elements. The analysis set out in the article is made in order to determine the field of relative displacement and equivalent stress in the load-bearing structure of the OCWFE. The structural model is generated in CAD-CAM. For the structural analysis, it is necessary the CAE model, which is obtained from the CAD-CAM model, mainly by eliminating gaps and interferences, but also by the techniques of realizing the contact between the components of the assembly and a careful mashing of the structure. The structural model thus created is supported and loaded in accordance with the experimental results from the literature. The relative displacement field and the equivalent stress field within the resistance frame of the OCWFE is obtained following the linear static analysis. The field of relative displacements is used to assess the effects on the quality of the work performed. The equivalent stress field is used to estimate the safety factor of the structure, by reference to the flow stress of the material from which the structure is built. [ABSTRACT FROM AUTHOR]

Published
2021
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31. DEVICE WITH CHISEL-TYPE WORKING PARTS FOR MEASURING THE TENSION STRENGTH INDEPENDENTLY ON EACH WORKING PART OR VARIOUS GROUPS OF WORKING PARTS.

Author

MURARU, Vergil, CÂRDEI, Petru, MURARU, Sebastian, MURARU-IONEL, Cornelia, CONDRUZ, Paula, and SFIRU, Raluca

Subjects
FARM tractors, PATENT applications, AGRICULTURAL equipment, TENSILE strength, MODULAR design, TILLAGE
Abstract

The paper presents a device with chisel-type working parts for measuring the tensile strength independently on each working parts or on various groups of working parts, equipped with devices designed for separate measurement, intended for complex research of agricultural machinery in interaction with the soil. The proposed solution is new and is based on flexibility and allows the mounting of various working parts in various positions. The functional model developed with elements of novelty and innovation led to the elaboration of a patent application, which refers to a loadbearing structure modulated with multiple applications for tillage machines, on which active parts are mounted in different working variants, in order to extension of the period of use, depending on the size of the agricultural exploitations and the power of the tractor. The modular design of the device will allow the development of a range of flexible cultivators that can be configured to in order to use power sources (tractors) from 30 hp to 90 hp, allowing the manufacturer to expand its market. [ABSTRACT FROM AUTHOR]

Published
2022

32. "OPEN INNOVATION ECOSYSTEM 2.0" DIGITAL PLATFORM FOR AGRICULTURE, FORESTRY AND FOOD INDUSTRY.

Author

MURARU, Sebastian Lucian, CARDEI, Petru, MURARU, Vergil, SFÎRU, Raluca, CONDRUZ, Paula, and MURARU-IONEL, Cornelia

Subjects
DIGITAL communications, FORESTS & forestry, OPEN innovation, DIGITAL technology, TECHNOLOGY transfer, FOOD industry
Abstract

The paper presents an "OPEN INNOVATION 2.0" digital platform that allows multilateral interaction between independent parties. The platform is based on a web portal and offers information, collaboration and communication resources and services for organizations and users who can work together and create value based on innovation. It facilitates transactions between customers and companies. The business environment, research institutions, civil society and public administration - Quadruple Helix model can work together in dynamic and diverse innovation ecosystems online through this platform. The digital platform contains specific instruments: innovative instrument for trading the demand and supply of RDI in the field of agriculture, forestry, food industry and related fields (databases with research results, patents and section dedicated to communication and discussions on topics specific to the trading of supply and demand of RDI; databases with entities involved in open innovation and technology transfer: Universities, Clusters, Stakeholders; open discussion forum to address new topics specific to innovation and technology transfer; e-learning section in the field of open innovation, agriculture, forestry and food industry, as well as related fields; events section, newsletter etc. [ABSTRACT FROM AUTHOR]

Published
2022

37. Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Author

Computer Science, Menden, Michael P., Wang, Dennis, Mason, Mike J., Szalai, Bence, Bulusu, Krishna C., Guan, Yuanfang, Yu, Thomas, Kang, Jaewoo, Jeon, Minji, Wolfinger, Russ, Nguyen, Tin, Zaslavskiy, Mikhail, Jang, In Sock, Ghazoui, Zara, Ahsen, Mehmet Eren, Vogel, Robert, Neto, Elias Chaibub, Norman, Thea, Tang, Eric K. Y., Garnett, Mathew J., Di Veroli, Giovanni Y., Fawell, Stephen, Stolovitzky, Gustavo, Guinney, Justin, Dry, Jonathan R., Saez-Rodriguez, Julio, Abante, Jordi, Abecassis, Barbara Schmitz, Aben, Nanne, Aghamirzaie, Delasa, Aittokallio, Tero, Akhtari, Farida S., Al-lazikani, Bissan, Alam, Tanvir, Allam, Amin, Allen, Chad, de Almeida, Mariana Pelicano, Altarawy, Doaa, Alves, Vinicius, Amadoz, Alicia, Anchang, Benedict, Antolin, Albert A., Ash, Jeremy R., Romeo Aznar, Victoria, Ba-alawi, Wail, Bagheri, Moeen, Bajic, Vladimir, Ball, Gordon, Ballester, Pedro J., Baptista, Delora, Bare, Christopher, Bateson, Mathilde, Bender, Andreas, Bertrand, Denis, Wijayawardena, Bhagya, Boroevich, Keith A., Bosdriesz, Evert, Bougouffa, Salim, Bounova, Gergana, Brouwer, Thomas, Bryant, Barbara, Calaza, Manuel, Calderone, Alberto, Calza, Stefano, Capuzzi, Stephen, Carbonell-Caballero, Jose, Carlin, Daniel, Carter, Hannah, Castagnoli, Luisa, Celebi, Remzi, Cesareni, Gianni, Chang, Hyeokyoon, Chen, Guocai, Chen, Haoran, Chen, Huiyuan, Cheng, Lijun, Chernomoretz, Ariel, Chicco, Davide, Cho, Kwang-Hyun, Cho, Sunghwan, Choi, Daeseon, Choi, Jaejoon, Choi, Kwanghun, Choi, Minsoo, De Cock, Martine, Coker, Elizabeth, Cortes-Ciriano, Isidro, Cserzo, Miklos, Cubuk, Cankut, Curtis, Christina, Van Daele, Dries, Dang, Cuong C., Dijkstra, Tjeerd, Dopazo, Joaquin, Draghici, Sorin, Drosou, Anastasios, Dumontier, Michel, Ehrhart, Friederike, Eid, Fatma-Elzahraa, ElHefnawi, Mahmoud, Elmarakeby, Haitham A., van Engelen, Bo, Engin, Hatice Billur, de Esch, Iwan, Evelo, Chris, Falcao, Andre O., Farag, Sherif, Fernandez-Lozano, Carlos, Fisch, Kathleen, Flobak, Asmund, Fornari, Chiara, Foroushani, Amir B. K., Fotso, Donatien Chedom, Fourches, Denis, Friend, Stephen, Frigessi, Arnoldo, Gao, Feng, Gao, Xiaoting, Gerold, Jeffrey M., Gestraud, Pierre, Ghosh, Samik, Gillberg, Jussi, Godoy-Lorite, Antonia, Godynyuk, Lizzy, Godzik, Adam, Goldenberg, Anna, Gomez-Cabrero, David, Gonen, Mehmet, de Graaf, Chris, Gray, Harry, Grechkin, Maxim, Guimera, Roger, Guney, Emre, Haibe-Kains, Benjamin, Han, Younghyun, Hase, Takeshi, He, Di, He, Liye, Heath, Lenwood S., Hellton, Kristoffer H., Helmer-Citterich, Manuela, Hidalgo, Marta R., Hidru, Daniel, Hill, Steven M., Hochreiter, Sepp, Hong, Seungpyo, Hovig, Eivind, Hsueh, Ya-Chih, Hu, Zhiyuan, Huang, Justin K., Huang, R. Stephanie, Hunyady, Laszlo, Hwang, Jinseub, Hwang, Tae Hyun, Hwang, Woochang, Hwang, Yongdeuk, Isayev, Olexandr, Walk, Oliver Bear Don't, Jack, John, Jahandideh, Samad, Ji, Jiadong, Jo, Yousang, Kamola, Piotr J., Kanev, Georgi K., Karacosta, Loukia, Karimi, Mostafa, Kaski, Samuel, Kazanov, Marat, Khamis, Abdullah M., Khan, Suleiman Ali, Kiani, Narsis A., Kim, Allen, Kim, Jinhan, Kim, Juntae, Kim, Kiseong, Kim, Kyung, Kim, Sunkyu, Kim, Yongsoo, Kim, Yunseong, Kirk, Paul D. W., Kitano, Hiroaki, Klambauer, Gunter, Knowles, David, Ko, Melissa, Kohn-Luque, Alvaro, Kooistra, Albert J., Kuenemann, Melaine A., Kuiper, Martin, Kurz, Christoph, Kwon, Mijin, van Laarhoven, Twan, Laegreid, Astrid, Lederer, Simone, Lee, Heewon, Lee, Jeon, Lee, Yun Woo, Leppaho, Eemeli, Lewis, Richard, Li, Jing, Li, Lang, Liley, James, Lim, Weng Khong, Lin, Chieh, Liu, Yiyi, Lopez, Yosvany, Low, Joshua, Lysenko, Artem, Machado, Daniel, Madhukar, Neel, De Maeyer, Dries, Malpartida, Ana Belen, Mamitsuka, Hiroshi, Marabita, Francesco, Marchal, Kathleen, Marttinen, Pekka, Mason, Daniel, Mazaheri, Alireza, Mehmood, Arfa, Mehreen, Ali, Michaut, Magali, Miller, Ryan A., Mitsopoulos, Costas, Modos, Dezso, Van Moerbeke, Marijke, Moo, Keagan, Motsinger-Reif, Alison, Movva, Rajiv, Muraru, Sebastian, Muratov, Eugene, Mushthofa, Mushthofa, Nagarajan, Niranjan, Nakken, Sigve, Nath, Aritro, Neuvial, Pierre, Newton, Richard, Ning, Zheng, De Niz, Carlos, Oliva, Baldo, Olsen, Catharina, Palmeri, Antonio, Panesar, Bhawan, Papadopoulos, Stavros, Park, Jaesub, Park, Seonyeong, Park, Sungjoon, Pawitan, Yudi, Peluso, Daniele, Pendyala, Sriram, Peng, Jian, Perfetto, Livia, Pirro, Stefano, Plevritis, Sylvia, Politi, Regina, Poon, Hoifung, Porta, Eduard, Prellner, Isak, Preuer, Kristina, Angel Pujana, Miguel, Ramnarine, Ricardo, Reid, John E., Reyal, Fabien, Richardson, Sylvia, Ricketts, Camir, Rieswijk, Linda, Rocha, Miguel, Rodriguez-Gonzalvez, Carmen, Roell, Kyle, Rotroff, Daniel, de Ruiter, Julian R., Rukawa, Ploy, Sadacca, Benjamin, Safikhani, Zhaleh, Safitri, Fita, Sales-Pardo, Marta, Sauer, Sebastian, Schlichting, Moritz, Seoane, Jose A., Serra, Jordi, Shang, Ming-Mei, Sharma, Alok, Sharma, Hari, Shen, Yang, Shiga, Motoki, Shin, Moonshik, Shkedy, Ziv, Shopsowitz, Kevin, Sinai, Sam, Skola, Dylan, Smirnov, Petr, Soerensen, Izel Fourie, Soerensen, Peter, Song, Je-Hoon, Song, Sang Ok, Soufan, Othman, Spitzmueller, Andreas, Steipe, Boris, Suphavilai, Chayaporn, Tamayo, Sergio Pulido, Tamborero, David, Tang, Jing, Tanoli, Zia-ur-Rehman, Tarres-Deulofeu, Marc, Tegner, Jesper, Thommesen, Liv, Tonekaboni, Seyed Ali Madani, Tran, Hong T., De Troyer, Ewoud, Truong, Amy, Tsunoda, Tatsuhiko, Turu, Gabor, Tzeng, Guang-Yo, Verbeke, Lieven, Videla, Santiago, Vis, Daniel, Voronkov, Andrey, Votis, Konstantinos, Wang, Ashley, Wang, Hong-Qiang Horace, Wang, Po-Wei, Wang, Sheng, Wang, Wei, Wang, Xiaochen, Wang, Xin, Wennerberg, Krister, Wernisch, Lorenz, Wessels, Lodewyk, van Westen, Gerard J. P., Westerman, Bart A., White, Simon Richard, Willighagen, Egon, Wurdinger, Tom, Xie, Lei, Xie, Shuilian, Xu, Hua, Yadav, Bhagwan, Yau, Christopher, Yeerna, Huwate, Yin, Jia Wei, Yu, Michael, Yu, MinHwan, Yun, So Jeong, Zakharov, Alexey, Zamichos, Alexandros, Zanin, Massimiliano, Zeng, Li, Zenil, Hector, Zhang, Frederick, Zhang, Pengyue, Zhang, Wei, Zhao, Hongyu, Zhao, Lan, Zheng, Wenjin, Zoufir, Azedine, Zucknick, Manuela, Computer Science, Menden, Michael P., Wang, Dennis, Mason, Mike J., Szalai, Bence, Bulusu, Krishna C., Guan, Yuanfang, Yu, Thomas, Kang, Jaewoo, Jeon, Minji, Wolfinger, Russ, Nguyen, Tin, Zaslavskiy, Mikhail, Jang, In Sock, Ghazoui, Zara, Ahsen, Mehmet Eren, Vogel, Robert, Neto, Elias Chaibub, Norman, Thea, Tang, Eric K. Y., Garnett, Mathew J., Di Veroli, Giovanni Y., Fawell, Stephen, Stolovitzky, Gustavo, Guinney, Justin, Dry, Jonathan R., Saez-Rodriguez, Julio, Abante, Jordi, Abecassis, Barbara Schmitz, Aben, Nanne, Aghamirzaie, Delasa, Aittokallio, Tero, Akhtari, Farida S., Al-lazikani, Bissan, Alam, Tanvir, Allam, Amin, Allen, Chad, de Almeida, Mariana Pelicano, Altarawy, Doaa, Alves, Vinicius, Amadoz, Alicia, Anchang, Benedict, Antolin, Albert A., Ash, Jeremy R., Romeo Aznar, Victoria, Ba-alawi, Wail, Bagheri, Moeen, Bajic, Vladimir, Ball, Gordon, Ballester, Pedro J., Baptista, Delora, Bare, Christopher, Bateson, Mathilde, Bender, Andreas, Bertrand, Denis, Wijayawardena, Bhagya, Boroevich, Keith A., Bosdriesz, Evert, Bougouffa, Salim, Bounova, Gergana, Brouwer, Thomas, Bryant, Barbara, Calaza, Manuel, Calderone, Alberto, Calza, Stefano, Capuzzi, Stephen, Carbonell-Caballero, Jose, Carlin, Daniel, Carter, Hannah, Castagnoli, Luisa, Celebi, Remzi, Cesareni, Gianni, Chang, Hyeokyoon, Chen, Guocai, Chen, Haoran, Chen, Huiyuan, Cheng, Lijun, Chernomoretz, Ariel, Chicco, Davide, Cho, Kwang-Hyun, Cho, Sunghwan, Choi, Daeseon, Choi, Jaejoon, Choi, Kwanghun, Choi, Minsoo, De Cock, Martine, Coker, Elizabeth, Cortes-Ciriano, Isidro, Cserzo, Miklos, Cubuk, Cankut, Curtis, Christina, Van Daele, Dries, Dang, Cuong C., Dijkstra, Tjeerd, Dopazo, Joaquin, Draghici, Sorin, Drosou, Anastasios, Dumontier, Michel, Ehrhart, Friederike, Eid, Fatma-Elzahraa, ElHefnawi, Mahmoud, Elmarakeby, Haitham A., van Engelen, Bo, Engin, Hatice Billur, de Esch, Iwan, Evelo, Chris, Falcao, Andre O., Farag, Sherif, Fernandez-Lozano, Carlos, Fisch, Kathleen, Flobak, Asmund, Fornari, Chiara, Foroushani, Amir B. K., Fotso, Donatien Chedom, Fourches, Denis, Friend, Stephen, Frigessi, Arnoldo, Gao, Feng, Gao, Xiaoting, Gerold, Jeffrey M., Gestraud, Pierre, Ghosh, Samik, Gillberg, Jussi, Godoy-Lorite, Antonia, Godynyuk, Lizzy, Godzik, Adam, Goldenberg, Anna, Gomez-Cabrero, David, Gonen, Mehmet, de Graaf, Chris, Gray, Harry, Grechkin, Maxim, Guimera, Roger, Guney, Emre, Haibe-Kains, Benjamin, Han, Younghyun, Hase, Takeshi, He, Di, He, Liye, Heath, Lenwood S., Hellton, Kristoffer H., Helmer-Citterich, Manuela, Hidalgo, Marta R., Hidru, Daniel, Hill, Steven M., Hochreiter, Sepp, Hong, Seungpyo, Hovig, Eivind, Hsueh, Ya-Chih, Hu, Zhiyuan, Huang, Justin K., Huang, R. Stephanie, Hunyady, Laszlo, Hwang, Jinseub, Hwang, Tae Hyun, Hwang, Woochang, Hwang, Yongdeuk, Isayev, Olexandr, Walk, Oliver Bear Don't, Jack, John, Jahandideh, Samad, Ji, Jiadong, Jo, Yousang, Kamola, Piotr J., Kanev, Georgi K., Karacosta, Loukia, Karimi, Mostafa, Kaski, Samuel, Kazanov, Marat, Khamis, Abdullah M., Khan, Suleiman Ali, Kiani, Narsis A., Kim, Allen, Kim, Jinhan, Kim, Juntae, Kim, Kiseong, Kim, Kyung, Kim, Sunkyu, Kim, Yongsoo, Kim, Yunseong, Kirk, Paul D. W., Kitano, Hiroaki, Klambauer, Gunter, Knowles, David, Ko, Melissa, Kohn-Luque, Alvaro, Kooistra, Albert J., Kuenemann, Melaine A., Kuiper, Martin, Kurz, Christoph, Kwon, Mijin, van Laarhoven, Twan, Laegreid, Astrid, Lederer, Simone, Lee, Heewon, Lee, Jeon, Lee, Yun Woo, Leppaho, Eemeli, Lewis, Richard, Li, Jing, Li, Lang, Liley, James, Lim, Weng Khong, Lin, Chieh, Liu, Yiyi, Lopez, Yosvany, Low, Joshua, Lysenko, Artem, Machado, Daniel, Madhukar, Neel, De Maeyer, Dries, Malpartida, Ana Belen, Mamitsuka, Hiroshi, Marabita, Francesco, Marchal, Kathleen, Marttinen, Pekka, Mason, Daniel, Mazaheri, Alireza, Mehmood, Arfa, Mehreen, Ali, Michaut, Magali, Miller, Ryan A., Mitsopoulos, Costas, Modos, Dezso, Van Moerbeke, Marijke, Moo, Keagan, Motsinger-Reif, Alison, Movva, Rajiv, Muraru, Sebastian, Muratov, Eugene, Mushthofa, Mushthofa, Nagarajan, Niranjan, Nakken, Sigve, Nath, Aritro, Neuvial, Pierre, Newton, Richard, Ning, Zheng, De Niz, Carlos, Oliva, Baldo, Olsen, Catharina, Palmeri, Antonio, Panesar, Bhawan, Papadopoulos, Stavros, Park, Jaesub, Park, Seonyeong, Park, Sungjoon, Pawitan, Yudi, Peluso, Daniele, Pendyala, Sriram, Peng, Jian, Perfetto, Livia, Pirro, Stefano, Plevritis, Sylvia, Politi, Regina, Poon, Hoifung, Porta, Eduard, Prellner, Isak, Preuer, Kristina, Angel Pujana, Miguel, Ramnarine, Ricardo, Reid, John E., Reyal, Fabien, Richardson, Sylvia, Ricketts, Camir, Rieswijk, Linda, Rocha, Miguel, Rodriguez-Gonzalvez, Carmen, Roell, Kyle, Rotroff, Daniel, de Ruiter, Julian R., Rukawa, Ploy, Sadacca, Benjamin, Safikhani, Zhaleh, Safitri, Fita, Sales-Pardo, Marta, Sauer, Sebastian, Schlichting, Moritz, Seoane, Jose A., Serra, Jordi, Shang, Ming-Mei, Sharma, Alok, Sharma, Hari, Shen, Yang, Shiga, Motoki, Shin, Moonshik, Shkedy, Ziv, Shopsowitz, Kevin, Sinai, Sam, Skola, Dylan, Smirnov, Petr, Soerensen, Izel Fourie, Soerensen, Peter, Song, Je-Hoon, Song, Sang Ok, Soufan, Othman, Spitzmueller, Andreas, Steipe, Boris, Suphavilai, Chayaporn, Tamayo, Sergio Pulido, Tamborero, David, Tang, Jing, Tanoli, Zia-ur-Rehman, Tarres-Deulofeu, Marc, Tegner, Jesper, Thommesen, Liv, Tonekaboni, Seyed Ali Madani, Tran, Hong T., De Troyer, Ewoud, Truong, Amy, Tsunoda, Tatsuhiko, Turu, Gabor, Tzeng, Guang-Yo, Verbeke, Lieven, Videla, Santiago, Vis, Daniel, Voronkov, Andrey, Votis, Konstantinos, Wang, Ashley, Wang, Hong-Qiang Horace, Wang, Po-Wei, Wang, Sheng, Wang, Wei, Wang, Xiaochen, Wang, Xin, Wennerberg, Krister, Wernisch, Lorenz, Wessels, Lodewyk, van Westen, Gerard J. P., Westerman, Bart A., White, Simon Richard, Willighagen, Egon, Wurdinger, Tom, Xie, Lei, Xie, Shuilian, Xu, Hua, Yadav, Bhagwan, Yau, Christopher, Yeerna, Huwate, Yin, Jia Wei, Yu, Michael, Yu, MinHwan, Yun, So Jeong, Zakharov, Alexey, Zamichos, Alexandros, Zanin, Massimiliano, Zeng, Li, Zenil, Hector, Zhang, Frederick, Zhang, Pengyue, Zhang, Wei, Zhao, Hongyu, Zhao, Lan, Zheng, Wenjin, Zoufir, Azedine, and Zucknick, Manuela

Abstract

The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca's large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.

Published
2019

38. INNOVATIVE METHODS FOR SPECIFIC APPLICATIONS AGAINST LATE SPRING FROST AFFECTING FRUIT TREES.

Author

COMAN, Mihai, CRISTEA, Oana-Diana, MURARU, Sebastian, MURARU-IONEL, Cornelia, MURARU, Vergil, and MARIN, Eugen

Subjects
FROST, FRUIT trees, ATMOSPHERIC temperature, TREE farms, SOIL temperature, SOIL air
Abstract

The paper presents one of the important objectives approached by the IND-AGRO-POL Cluster Association on providing technical advice to the fruit- growing farmers by addressing innovative methods for specific applications against fruit trees late spring frosts. The paper presents briefly and easily understandable the current state of knowledge regarding the protection against frosts of fruit tree plantations, offering practical advice for optimal planning according to the working conditions of the Romanian fruit tree farms that lead to reducing the consequences and combating the frosts by reducing the radiative cooling, destructing the thermal inversion layer from the soil, homogenizing the air temperature in the microclimatic layer and consequently, maintaining the air temperature on the soil surface above 0°C. [ABSTRACT FROM AUTHOR]

Published
2020

40. Mathematical modelling and numerical simulation of linear electro-hydraulic servomechanism with stepper motor.

Author

Muraru, Vergil, Calinoiu, Constantin, Muraru, Sebastian, Dulgheru, Ana, and Muraru-Ionel, Cornelia

Subjects
HYDRAULIC servomechanisms, STEPPING motors, MATHEMATICAL models, SIMULATION software, COMPUTER simulation, ELECTROMECHANICAL technology, ELECTRIC motors
Abstract

The paper presents the results of research on the performance of linear electro-hydraulic servomechanisms with stepper motor, evaluated by mathematical modelling and numerical simulation with the AMESIM software package. These servomechanisms have a great potential for application, including for agricultural technical equipment. Servomechanisms of various types are used for the rapid and high precision operation of the various systems. In practice, electro-hydraulic servomechanisms have been required in the case of the systems requiring high forces or moments. These equipment are automatic hydraulic tracking systems and can be analysed with methods specific to automatic systems. The paper contains a structural description of an electro-mechanical servomechanism with stepper motor, its operation, mathematical model and its performances obtained by numerical simulation. The mathematical modelling of the electro-hydraulic servomechanism is based on the relations between the input sizes and output sizes of the equipment in its structure as well as the connection relations between these equipment. Based on the obtained results it is demonstrated that the analysis and synthesis of electro-hydraulic servomechanisms with stepper motor can be determined by numerical simulation using the AMESIM simulation software. [ABSTRACT FROM AUTHOR]

Published
2020
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41. Soil moisture influence in the soil tillage operations.

Author

Cardei, Petru, Sfiru, Raluca, Muraru, Sebastian, and Condruz, Paula

Subjects
SOIL moisture, TILLAGE, SOIL density measurement, AGRICULTURAL equipment models, AGRICULTURAL technology
Abstract

This article presents results obtained by the author in an attempt to introduce new parameters that influence the working process of agricultural soil working machines, in the classical formulas that mathematically model the tillage draft force. This article naturally introduces soil moisture. To introduce soil moisture into the calculation formulas of the tillage draft force, other physical parameters affected by soil moisture were used: density, cohesion, adhesion, etc. In this article, is explicitly describes, only the variation of soil density with its moisture. Considering some phenomena such as soil swelling or shrinkage, required the development of an adequate mathematical model of the expression of the density of soil-water mixture, concerning the concentration of water and the densities of dry soil and water. The final formulas obtained are tested to experimental results from the literature. Finally, the author sets out his opinion regarding the use of the results in design calculations and regarding the elevation to the rank of physical law of a mathematical model represented by a formula with a large number of parameters, which in turn are still dependent on many others parameters. [ABSTRACT FROM AUTHOR]

Published
2020
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45. USING SPEECH RECOGNITION IN AGRICULTURE.

Author

CONDRUZ, PAULA, MURARU, SEBASTIAN-LUCIAN, MURARU, VERGIL, MURARU-IONEL, CORNELIA, and CRISTEA, OANA DIANA

Subjects
*SPEECH perception, *AUTOMATIC speech recognition, *INTERACTIVE voice response (Telecommunication), *HUMAN-machine systems, *NATURAL language processing, *PROGRAMMING languages
Abstract

The importance of computers has become very popular, the interaction between man and machine is indispensable every day. People's need and desire to communicate with machines naturally led to the evolution of natural language processing. While progress is being made in this area, it is likely that voice interaction systems will replace most portable and digital devices such as keyboards, card readers, etc. This paper presents the main paradigms for speaker recognition, being one of the most important and needed biometric feature and it also focuses on the use of these biometric technology for interactive voice response system for agriculture assistance to farmers. Agriculture has been the primary occupation of human being. Generally farmers do not have the scientific information or competence to find out the cause and solution of any situation that could appear as diseases of their animals or even crops, behavioral features etc. They could have difficulties with understanding machine language or even typing. To facilitate the farmer’s access to information regarding the solution of a specific kind of livestock or crops matter this paper proposes a concept of an interactive voice response system through their mobile phones; a model with voice response in many languages. This model will be advantageous in following conditions: for people with disabilities, people with few PC knowledge or even those who are very busy. Biometric recognition or, simply, biometrics refers to the automatic recognition of individuals based on their physiological and/or behavioral characteristics. The voice is a physiological feature (each person has a different vocal tract), but the recognition of a speaker is mainly based on the study of how it speaks, usually classified as behavioral. Speech recognition is a multi-application domain: security of any kind, telecommunication, daily activities, and now it could be used in agricultural situation. Speech Recognition summarizes a variety of issues such as recognizing isolated words, identifying speakers based on their voice tag, recognizing phonemes, etc. The utility of identifying people based on their voice is growing with the development of automation and telecommunication, and, also regarding the new-entry telephone line applications, the need to recognize the speaker has become more pressing. Speech recognition has a particularly high applicability due to the fact that this method is non-intrusive, universally accepted, with acceptable accuracy, and speech samples are easily sampled either by phone or by microphone. [ABSTRACT FROM AUTHOR]

Published
2019
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46. INNOVATIVE AND CROSS-SECTORAL CLUSTERS AS FACILITATORS OF VALUE ADDED CHAINS IN AGRICULTURE - SMART AGRO CLUSTERS IN ROMANIA.

Author

MURARU-IONEL, Cornelia, MURARU, Sebastian Lucian, CRISTEA, Oana-Diana, and CONDRUZ, Paula

Subjects
*VALUE chains, *MANUFACTURING processes, *ECONOMIC sectors, *ORIGINALITY, *JOB creation
Abstract

Clusters play an important role in driving competitiveness, innovation and jobs creation in the EU. Romania currently has successful clusters in various economic sectors and services, including 7 clusters in agro-food. Agriculture has been and remains the support of the human existence, which is an important pillar of the Romanian rural economy. The agro-food sector had oscillating evolutions in the post-accession period, mainly generated by the need to get in line with the EU requirements. Stimulating smart technology assimilation across all economic sectors including agro-food value chains, promoting enterprise growth and clusters 4.0 is critical to many EU Member States. Partnerships between countries, regions, cities and clusters are essential in the next industrial modernization process, based on innovation. Clusters 4.0 calls for development of a generation of advanced cluster policies to respond to these new industrial challenges by facilitating cross-sectoral value chains, fostering internationalization, stimulating inter-regional investment and accelerating entrepreneurship and skills in digital production, environmental production, circular economy, service innovation and creative economy. In order to be ready for the future, clusters must be geared towards creating a smart value chains, international cooperation and cross-sectoral partnerships. This research paper proposes a model as a tool for agro-clusters to become "smart", also this proposal providing information on the most important steps in the creation and development of smart agro-clusters. The used research methodology was based on analysis and synthesis of the information on the economic and social aspects of the development of the agro-food sector and of clusters in Romania. In conclusion, the authors of this paper wanted to emphasize the necessity of the development of smart agro-clusters for the future smart specialization of the regions. [ABSTRACT FROM AUTHOR]

Published
2019
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47. OPEN INNOVATION IN AGRO-FOOD CLUSTERS IN ROMANIA.

Author

Muraru, Vergil-Marian, Cristea, Oana Diana, Muraru, Sebastian Lucian, Dulgheru, Ana, and Berevoianu, Bogdan

Subjects
OPEN innovation, FOOD industry, AGRICULTURAL economics, NEW product development
Abstract

Open innovation is a new paradigm for the development of agribusiness in Romania and the Danube macro-region. Studies on agro-food chains and clusters are still scarce. In the Romanian agro-food sector, 7 regional and cross-regional clusters are very active. This study aims to present the state of the art on open innovation in agribusiness in Romania, identifying how it is adopted, the role of clusters and the factors that influence this process, a collaborative platform for agro-food clusters and their members and future research possibilities. Is a need for internal organizational changes, the support of communication tools and an intellectual property model that encourage knowledge sharing. The main obstacles to the implementation of the digitization process in the agro-food sector are lack of expertise, high costs or in compatibility with the field of activity. Open innovation is a field that needs to be explored in different links in the chain, clusters being facilitators of this process. The challenges of agribusiness today demand more complex and systemic innovations that can be achieved through more open processes of product development. Clusters from agro-food sector are increasingly opening their innovation processes, streamlining their research and development activities with the expectation of better results. In general, the main barrier in establishing innovation alliances refers to the inherent risk of knowledge sharing, which creates a lack of trust between partners. The study could be a good practice model for other countries from the Danube macro-region. [ABSTRACT FROM AUTHOR]

Published
2019
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48. Drones and windbreaks.

Author

Cardei, Petru, Muraru, Sebastian, and Matache, Mihai

Subjects
WINDBREAKS, shelterbelts, etc., DRONE aircraft, POROSITY, WIND speed, ENERGY consumption
Abstract

The article presents a possibility of applying the techniques specific to the drones (UAV) in order to estimate the efficiency, and optimize the windbreaks (vegetative barriers, forest curtains).In the first part the article presents a variant of determination of the dynamic and optical porosities of forest protection curtains using one or two drones simultaneously. In the second part, ascertaining some language inaccuracies, it observes that the issue of the efficiency of the forest curtains became a problem of mitigation of wind intensity. Finally, the last proposed application shows that using the drones, you can estimate the protected volumes behind the curtains, basically giving up the optical porosity. In order to achieve these applications, there is an essential condition: records of the magnitude of the wind speed and of the coordinates must not be excessively affected by the wind. [ABSTRACT FROM AUTHOR]

Published
2019
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