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12. Two Relapsed Stage III Childhood Anaplastic Large Cell Lymphoma Patients with NPM-ALK Fusion in Bone Marrow from Initial Diagnosis

Author

Kanazawa, Y., Yamashita, Y., Fujiwara, M., Muraoka, M., Washio, K., Kanamitsu, K., Ishida, H., Nakano, T., Yamada, M., Horibe, K., Tanaka, T., Yoshino, T., and Akira SHIMADA

Subjects
Antibodies, Neoplasm, Recurrence, hemic and lymphatic diseases, Humans, Lymphoma, Large-Cell, Anaplastic, Receptor Protein-Tyrosine Kinases, Anaplastic Lymphoma Kinase, Antineoplastic Agents, lymphoma, NPM-ALK fusion, Child, ALCL
Abstract

Childhood anaplastic large cell lymphoma (ALCL) accounts for approx. 10-30% of cases of non-Hodgkin lymphoma, and the ALCL99 study reported 60-75 disease-free survival; however, a relatively high relapse rate was observed (25-30% ). We report 2 patients with Stage III ALCL who relapsed 6-18 months after the end of ALCL99 chemotherapy. A retrospective molecular analysis identified the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) fusion gene in the first diagnostic bone marrow samples taken from both patients. However, antibodies against the ALK protein appeared to be relatively low in the serum of both patients (×100 and ×750). An increase in chemotherapy intensity may be beneficial if Stage III ALCL patients are shown to be NPM-ALK chimera-positive in the first diagnostic bone marrow sample.

Published
2016

18. A Long-term Survivor after Congenital Acute Myeloid Leukemia with t(8 ; 16)(p11 ; p13)

Author

Hanada, T., Kanamitsu, K., Chayama, K., Miyamura, T., Kanazawa, Y., Muraoka, M., Washio, K., Imada, M., Kageyama, M., Akihito Takeuchi, Tamai, K., Oda, M., and Shimada, A.

Subjects
Gene Rearrangement, Oncogene Proteins, Fusion, Sequence Analysis, RNA, Infant, Newborn, congenital leukemia, Leukemia, Myeloid, Acute, AML, hemic and lymphatic diseases, Humans, Female, MOZ-CBP, RNA, Neoplasm, Survivors, t(8, 16)(p11, p13), Chromosomes, Human, Pair 16, Chromosomes, Human, Pair 8
Abstract

The treatment of patients with congenital leukemia is difficult and often results in a poor prognosis. We present here the case of a female child with congenital acute myeloid leukemia (AML) with t(8 ; 16) (p11 ; p13) who received chemotherapy and survived for more than 10 years without relapse. A novel MOZ-CBP chimera was found in her diagnostic sample. Although adult AML patients with MOZ-CBP have mainly been reported as having therapy-related AML and showed poor prognoses, the present case supports the idea that AML with MOZ-CBP in the pediatric population might show better prognoses.

Published
2016

20. The distribution of the stress intensity factor along the front of the growing crack in an optical glass fiber

Author

Muraoka, M., Abe, H., and Aizawa, N.

Subjects
Fiber optics -- Evaluation, Stress concentration -- Analysis, Fracture mechanics -- Research, Electronics
Abstract

The stress intensity factor K(sub I) along the front edge of a growing small crack in a silica optical fiber was evaluated by 3-D boundary element analysis based on the crack geometry observed during the delayed fracture test. The variation of K(sub I) was shown to be little along the front of the growing crack. The crack velocity in the direction normal to the crack front was able to be expressed as a power function of K(sub I) at each position on the crack front. The crack velocity was also shown to be larger at a position closer to the fiber surface for each value of K(sub I).

Published
1992

22. Onoda's OPG system successfully adopted by PT Semen Nusantara

Author

Muraoka, M. and Masuda, H.

Subjects
PT Semen Nusantara -- Equipment and supplies, Cement industry -- Equipment and supplies, Cement plants -- Equipment and supplies, Business, Business, international, Construction and materials industries
Abstract

Indonesian cement producer PT Semen Nusantara has installed OPG systems supplied by Onoda Engineering in some of its clinker grinding units. The flexible systems will allow for a substantial increase in cement clinker grinding capacity and give savings in energy consumption and maintenance costs. A description of the system is presented.

Published
1996

23. P1.16-59 A Phase II Study of Adjuvant Chemotherapy with Tegafur-Uracil for Vessel Invasion Positive Stage IA Non-Small Cell Lung Cancer (LOGIK0602)

Author

Tsuchiya, T., primary, Nagayasu, T., additional, Kamohara, R., additional, Muraoka, M., additional, Saeki, S., additional, Ichinose, Y., additional, Suzuki, M., additional, Inada, K., additional, Tokunaga, S., additional, Hayashi, T., additional, Urabe, S., additional, Koga, T., additional, Akamine, S., additional, and Sugio, K., additional

Published
2018
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26. Psychogenic vomiting: the relation between patterns of vomiting and psychiatric diagnoses

Author

Muraoka, M., Mine, K., Matsumoto, K., Nakai, Y., and Nakagawa, T.

Subjects
Eating disorders -- Psychological aspects, Mental illness -- Physiological aspects, Vomiting -- Psychological aspects, Health
Abstract

Vomiting, or the forceful expulsion of gastric contents through the mouth, is most often an effort by the body to rid itself of toxic materials, or an indication of intestinal blockage. In some cases, patients vomit in the absence of any physical cause; this phenomenon is known as psychogenic vomiting. It has been suggested that there may be a relation between the pattern of psychogenic vomiting and the underlying psychiatric disorder. To investigate this possibility, 59 patients (41 women and 19 men; average age 28 years) who were admitted to a psychiatric clinic for psychogenic vomiting were classified according to the pattern of vomiting, and underwent a psychiatric diagnosis to determine existing psychopathology. Five distinct patterns of vomiting could be distinguished: continuous, habitual postprandial (following meals), irregular, nausea-induced and self-induced. In patients with continuous vomiting, which was observed in 22 of the 59 cases, the psychiatric diagnosis in 91 percent of the cases was conversion disorder (a type of hysterical neurosis manifesting itself as an apparent bodily dysfunction). Conversely, 65 percent of the patients with conversion disorders exhibited continuous vomiting. In patients with habitual postprandial and irregular vomiting, the most common psychiatric diagnosis was major depression. Of the patients with postprandial vomiting, which was usually associated with weight loss, major depression was seen in 64 percent of the cases; the remainder exhibited conversion disorders. In other types of vomiting, patients tended to exhibit one of these disorders, or in a number of cases, simply generalized anxiety. Frequently, the pattern of vomiting, the psychiatric profile, or both changed during the course of clinical treatment. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

29. Characteristics of benzo(a)pyrene in highway runoff pollution

Author

Wada, Y., Ozaki, T., and Muraoka, M.

Subjects
Highway runoff pollutant, benzo(a)pyrene concentration, runoff model, complex mixtures, human activities, design rainfall of patterns
Abstract

The influence on receiving water of highway runoff is considered to be serious in Japan. On the road surface, tire wear, automobile exhaust emissions, floating in the atmosphere and so on, accumulate on the road surface and in its lateral ditches. This polluted matter is discharged by stormwater into the receiving water. These accumulated pollution loads contain harmful materials to both the human body and the ecosystem. In this study, the amount of accumulated pollutants and highway runoff pollutants were investigated by the authors. In order to grasp the characteristics of benzo(a)pyrene in highway runoff pollution, we calculated the concentration of benzo(a)pyrene using design rainfall. In order to evaluate the influence of the public water bodies by inflow of benzo(a)pyrene, predicted no effect concentration (PNEC) was used as the indicator in this research. PNEC of benzo(a)pyrene is 0.005 \302\265g/L. The maximum concentration of runoff water (Cmax) and total of the product of concentration and outflow time (ΣCT) are exceeding PNEC. Cmax and ΣCT of central peak design rainfall are the highest in the design rainfalls. In the case of central peak design rainfall, the influence on receiving water of highway runoff is the highest.

Published
2005
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32. P571 GADOLINIUM ETHOXYBENZYL DIETHYLENETRIAMINEPENTAACETIC ACID MAGNETIC RESONANCE IMAGING AND CONTRAST ENHANCED ULTRASONOGRAPHY WITH SONAZOID AS PART OF THERAPEUTIC STRATEGIES FOR SMALL NONHYPERVASCULAR HEPATIC NODULAR LESIONS

Author

Tsuchiya, K., primary, Yasui, Y., additional, Takada, H., additional, Nakakuki, N., additional, Matsuda, S., additional, Kaneko, S., additional, Muraoka, M., additional, Yamashita, K., additional, Hattori, N., additional, Tamaki, N., additional, Osaki, R., additional, Suzuki, S., additional, Hosokawa, T., additional, Ueda, K., additional, Nakanishi, H., additional, Itakura, J., additional, Takahashi, Y., additional, Kurosaki, M., additional, Asahina, Y., additional, and Izumi, N., additional

Published
2014
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33. P982 MULTIDISCIPLINARY TREATMENTS IMPROVE SURVIVAL IN PATIENTS WITH ADVANCED HEPATOCELLULAR CARCINOMA: ANALYZING THE SURVIVAL RATE OF PATIENTS AFTER SORAFENIB ADMINISTRATION

Author

Hattori, N., primary, Tsuchiya, K., additional, Nakakuki, N., additional, Takada, H., additional, Matsuda, S., additional, Kaneko, S., additional, Muraoka, M., additional, Tamaki, N., additional, Yasui, Y., additional, Osaki, R., additional, Suzuki, S., additional, Hosokawa, T., additional, Nakanishi, H., additional, Itakura, J., additional, Takahashi, Y., additional, Kurosaki, M., additional, and Izumi, N., additional

Published
2014
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34. P553 ELASTIC FIBER ACCUMULATION ESTIMATED BY A NOVEL AUTOMATED COMPUTATIONAL ANALYSIS AS A SIGNIFICANT PREDICTING FACTOR FOR THE DEVELOPMENT OF HEPATOCELLULAR CARCINOMA

Author

Yasui, Y., primary, Abe, T., additional, Takada, H., additional, Nakakuki, N., additional, Matsuda, S., additional, Kaneko, S., additional, Muraoka, M., additional, Yamashita, K., additional, Hattori, N., additional, Tamaki, N., additional, Osaki, R., additional, Suzuki, S., additional, Hosokawa, T., additional, Ueda, K., additional, Nakanishi, H., additional, Tsuchiya, K., additional, Itakura, J., additional, Takahashi, Y., additional, Kurosaki, M., additional, Hashiguchi, A., additional, Sakamoto, M., additional, and Izumi, N., additional

Published
2014
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36. A method to evaluating local elasticity and adhesion energy from the nonlinear response of AFM cantilever vibrations

Author

Muraoka, M., Arnold, W., and Publica

Subjects
local elasticity, nonlinear vibration, adhesion energy, micro-cantilever, Atomic Force Microscopy (AFM), material characterization, dynamic contact operation
Abstract

The resonance frequency of a micro-cantilever employed in atomic force microscopy (AFM) is expected to be a measure of tip-sample contact stiffness representing the elastic properties of a sample. Quantitative evaluation of the elastic properties from measurements of resonance frequency is difficult, however, because contact stiffness is influenced by adhesion energy as well as elastic properties. In this study, we propose a new method of evaluating these properties quantitatively from the nonlinear response of AFM cantilever vibrations. The nonlinear vibrations are easily excited due to the non-linearity in the tip-sample interaction. To simplify the formulas derived for evaluation of contact stiffness and adhesion, we focus on the case of perfect contact, where the tip is always in contact with the sample surface. The elastic properties and the adhesion energy are separated by finding the optimal set of values which minimizes the difference between the theoretical and experimental relationship of resonance frequency versus amplitude.

Published
2001

40. A Mathematical Model for Predicting Outcome in Preterm Labour

Author

Takagi, K, primary, Satoh, K, additional, Muraoka, M, additional, Takagi, K, additional, Seki, H, additional, Nakabayashi, M, additional, Takeda, S, additional, Yoshida, K, additional, Nishioka, N, additional, Ikenoue, T, additional, Kanayama, N, additional, Kanzaki, T, additional, Sagawa, T, additional, and Matsuda, Y, additional

Published
2012
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42. 690 SUPPRESSION OF ALPHA-FETOPROTEIN BY INTERFERON THERAPY REDUCES THE RISK OF HEPATOCARCINOGENESIS IN PATIENTS WITH CHRONIC HEPATITIS C

Author

Asahina, Y., primary, Tsuchiya, K., additional, Muraoka, M., additional, Tanaka, K., additional, Suzuki, Y., additional, Tamaki, N., additional, Hoshioka, Y., additional, Katoh, T., additional, Yasui, Y., additional, Hosokawa, T., additional, Ueda, K., additional, Nakanishi, H., additional, Itakura, J., additional, Takahashi, Y., additional, Kurosaki, M., additional, and Izumi, N., additional

Published
2012
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43. 1038 DECREASE OF PLASMA VEGF LEVEL WITHIN 2 MONTHS AFTER SORAFENIB ADMINISTRATION PREDICTS TREATMENT EFFICACY AND PROGNOSIS IN PATIENTS WITH ADVANCED HEPATOCELLULAR CARCINOMA

Author

Tsuchiya, K., primary, Asahina, Y., additional, Muraoka, M., additional, Tanaka, K., additional, Suzuki, Y., additional, Hoshioka, Y., additional, Tamaki, N., additional, Kato, T., additional, Yasui, Y., additional, Hosokawa, T., additional, Ueda, K., additional, Nakanishi, H., additional, Itakura, J., additional, Takahashi, Y., additional, Kurosaki, M., additional, and Izumi, N., additional

Published
2012
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