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38 results on '"Munthe-Kaas, Monica Cheng"'

1. Epigenome-wide analysis across the development span of pediatric acute lymphoblastic leukemia: backtracking to birth

Author

Ghantous, Akram, Nusslé, Semira Gonseth, Nassar, Farah J., Spitz, Natalia, Novoloaca, Alexei, Krali, Olga, Nickels, Eric, Cahais, Vincent, Cuenin, Cyrille, Roy, Ritu, Li, Shaobo, Caron, Maxime, Lam, Dilys, Fransquet, Peter Daniel, Casement, John, Strathdee, Gordon, Pearce, Mark S., Hansen, Helen M., Lee, Hwi-Ho, Lee, Yong Sun, de Smith, Adam J., Sinnett, Daniel, Håberg, Siri Eldevik, McKay, Jill A., Nordlund, Jessica, Magnus, Per, Dwyer, Terence, Saffery, Richard, Wiemels, Joseph Leo, Munthe-Kaas, Monica Cheng, and Herceg, Zdenko

Published
2024
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2. A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation

Author

Li, Shaobo, Spitz, Natalia, Ghantous, Akram, Abrishamcar, Sarina, Reimann, Brigitte, Marques, Irene, Silver, Matt J., Aguilar-Lacasaña, Sofía, Kitaba, Negusse, Rezwan, Faisal I., Röder, Stefan, Sirignano, Lea, Tuhkanen, Johanna, Mancano, Giulia, Sharp, Gemma C., Metayer, Catherine, Morimoto, Libby, Stein, Dan J., Zar, Heather J., Alfano, Rossella, Nawrot, Tim, Wang, Congrong, Kajantie, Eero, Keikkala, Elina, Mustaniemi, Sanna, Ronkainen, Justiina, Sebert, Sylvain, Silva, Wnurinham, Vääräsmäki, Marja, Jaddoe, Vincent W. V., Bernstein, Robin M., Prentice, Andrew M., Cosin-Tomas, Marta, Dwyer, Terence, Håberg, Siri Eldevik, Herceg, Zdenko, Magnus, Maria C., Munthe-Kaas, Monica Cheng, Page, Christian M., Völker, Maja, Gilles, Maria, Send, Tabea, Witt, Stephanie, Zillich, Lea, Gagliardi, Luigi, Richiardi, Lorenzo, Czamara, Darina, Räikkönen, Katri, Chatzi, Lida, Vafeiadi, Marina, Arshad, S. Hasan, Ewart, Susan, Plusquin, Michelle, Felix, Janine F., Moore, Sophie E., Vrijheid, Martine, Holloway, John W., Karmaus, Wilfried, Herberth, Gunda, Zenclussen, Ana, Streit, Fabian, Lahti, Jari, Hüls, Anke, Hoang, Thanh T., London, Stephanie J., and Wiemels, Joseph L.

Published
2024
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3. Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence

Author

Choudhary, Priyanka, Monasso, Giulietta S, Karhunen, Ville, Ronkainen, Justiina, Mancano, Giulia, Howe, Caitlin G, Niu, Zhongzheng, Zeng, Xuehuo, Guan, Weihua, Dou, John, Feinberg, Jason I, Mordaunt, Charles, Pesce, Giancarlo, Baïz, Nour, Alfano, Rossella, Martens, Dries S, Wang, Congrong, Isaevska, Elena, Keikkala, Elina, Mustaniemi, Sanna, Thio, Chris HL, Fraszczyk, Eliza, Tobi, Elmar W, Starling, Anne P, Cosin-Tomas, Marta, Urquiza, Jose, Röder, Stefan, Hoang, Thanh T, Page, Christian, Jima, Dereje D, House, John S, Maguire, Rachel L, Ott, Raffael, Pawlow, Xenia, Sirignano, Lea, Zillich, Lea, Malmberg, Anni, Rauschert, Sebastian, Melton, Phillip, Gong, Tong, Karlsson, Robert, Fore, Ruby, Perng, Wei, Laubach, Zachary M, Czamara, Darina, Sharp, Gemma, Breton, Carrie V, Schisterman, Enrique, Yeung, Edwina, Mumford, Sunni L, Fallin, M Daniele, LaSalle, Janine M, Schmidt, Rebecca J, Bakulski, Kelly M, Annesi-Maesano, Isabella, Heude, Barbara, Nawrot, Tim S, Plusquin, Michelle, Ghantous, Akram, Herceg, Zdenko, Nisticò, Lorenza, Vafeiadi, Marina, Kogevinas, Manolis, Vääräsmäki, Marja, Kajantie, Eero, Snieder, Harold, Corpeleijn, Eva, Steegers-Theunissen, Regine PM, Yang, Ivana V, Dabelea, Dana, Fossati, Serena, Zenclussen, Ana C, Herberth, Gunda, Magnus, Maria, Håberg, Siri E, London, Stephanie J, Munthe-Kaas, Monica Cheng, Murphy, Susan K, Hoyo, Cathrine, Ziegler, Anette-G, Hummel, Sandra, Witt, Stephanie H, Streit, Fabian, Frank, Josef, Räikkönen, Katri, Lahti, Jari, Huang, Rae-chi, Almqvist, Catarina, Hivert, Marie-France, Jaddoe, Vincent WV, Järvelin, Marjo-Riitta, Kantomaa, Marko, Felix, Janine F, and Sebert, Sylvain

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Pediatric, Genetics, Human Genome, Social Determinants of Health, Maternal Health, Prevention, Pregnancy, Nutrition, Women's Health, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, 1.1 Normal biological development and functioning, Generic health relevance, Reproductive health and childbirth, Good Health and Well Being, Humans, DNA Methylation, Female, Adolescent, Epigenome, Child, Educational Status, Male, Genome-Wide Association Study, Epigenesis, Genetic, Prenatal Exposure Delayed Effects, Child, Preschool, Infant, Mothers, Infant, Newborn, Adult, Academic Success, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed to quantify the associations of MEA with offspring DNA methylation levels at birth, in childhood and in adolescence. Using 37 studies from high-income countries, we performed meta-analysis of epigenome-wide association studies (EWAS) to quantify the associations of completed years of MEA at the time of pregnancy with offspring DNA methylation levels at birth (n = 9 881), in childhood (n = 2 017), and adolescence (n = 2 740), adjusting for relevant covariates. MEA was found to be associated with DNA methylation at 473 cytosine-phosphate-guanine sites at birth, one in childhood, and four in adolescence. We observed enrichment for findings from previous EWAS on maternal folate, vitamin-B12 concentrations, maternal smoking, and pre-pregnancy BMI. The associations were directionally consistent with MEA being inversely associated with behaviours including smoking and BMI. Our findings form a bridge between socio-economic factors and biology and highlight potential pathways underlying effects of maternal education. The results broaden our understanding of bio-social associations linked to differential DNA methylation in multiple early stages of life. The data generated also offers an important resource to help a more precise understanding of the social determinants of health.

Published
2024

4. Proteogenomic analysis of acute myeloid leukemia associates relapsed disease with reprogrammed energy metabolism both in adults and children

Author

Stratmann, Svea, Vesterlund, Mattias, Umer, Husen M., Eshtad, Saeed, Skaftason, Aron, Herlin, Morten Krogh, Sundström, Christer, Eriksson, Anna, Höglund, Martin, Palle, Josefine, Abrahamsson, Jonas, Jahnukainen, Kirsi, Munthe-Kaas, Monica Cheng, Zeller, Bernward, Tamm, Katja Pokrovskaja, Lindskog, Cecilia, Cavelier, Lucia, Lehtiö, Janne, and Holmfeldt, Linda

Published
2023
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5. Transcriptomic analysis reveals proinflammatory signatures associated with acute myeloid leukemia progression

Author

Stratmann, Svea, Yones, Sara A., Garbulowski, Mateusz, Sun, Jitong, Skaftason, Aron, Mayrhofer, Markus, Norgren, Nina, Herlin, Morten Krogh, Sundström, Christer, Eriksson, Anna, Höglund, Martin, Palle, Josefine, Abrahamsson, Jonas, Jahnukainen, Kirsi, Munthe-Kaas, Monica Cheng, Zeller, Bernward, Tamm, Katja Pokrovskaja, Cavelier, Lucia, Komorowski, Jan, and Holmfeldt, Linda

Published
2022
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6. Correction to: Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway

Author

Helland, Åslaug, Russnes, Hege G., Fagereng, Gro Live, Al-Shibli, Khalid, Andersson, Yvonne, Berg, Thomas, Bjørge, Line, Blix, Egil, Bjerkehagen, Bodil, Brabrand, Sigmund, Cameron, Marte Grønlie, Dalhaug, Astrid, Dietzel, Dalia, Dønnem, Tom, Enerly, Espen, Flobak, Åsmund, Fluge, Sverre, Gilje, Bjørnar, Gjertsen, Bjørn Tore, Grønberg, Bjørn Henning, Grønås, Kari, Guren, Tormod, Hamre, Hanne, Haug, Åse, Heinrich, Daniel, Hjortland, Geir Olav, Hovig, Eivind, Hovland, Randi, Iversen, Ann-Charlotte, Janssen, Emiel, Kyte, Jon Amund, von der Lippe Gythfeldt, Hedda, Lothe, Ragnhild, Lund, Jo-Åsmund, Meza-Zepeda, Leonardo, Munthe-Kaas, Monica Cheng, Nguyen, Olav Toai Duc, Niehusmann, Pitt, Nilsen, Hilde, Puco, Katarina, Ree, Anne Hansen, Riste, Tonje Bøyum, Semb, Karin, Steinskog, Eli Sihn Samdal, Stensvold, Andreas, Suhrke, Pål, Tennøe, Øyvind, Tjønnfjord, Geir E., Vassbotn, Liv Jorunn, Aas, Eline, Aasebø, Kristine, Tasken, Kjetil, and Smeland, Sigbjørn

Published
2022
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7. Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway

Author

Helland, Åslaug, Russnes, Hege G., Fagereng, Gro Live, Al-Shibli, Khalid, Andersson, Yvonne, Berg, Thomas, Bjørge, Line, Blix, Egil, Bjerkehagen, Bodil, Brabrand, Sigmund, Cameron, Marte Grønlie, Dalhaug, Astrid, Dietzel, Dalia, Dønnem, Tom, Enerly, Espen, Flobak, Åsmund, Fluge, Sverre, Gilje, Bjørnar, Gjertsen, Bjørn Tore, Grønberg, Bjørn Henning, Grønås, Kari, Guren, Tormod, Hamre, Hanne, Haug, Åse, Heinrich, Daniel, Hjortland, Geir Olav, Hovig, Eivind, Hovland, Randi, Iversen, Ann-Charlotte, Janssen, Emiel, Kyte, Jon Amund, von der Lippe Gythfeldt, Hedda, Lothe, Ragnhild, Lund, Jo-Åsmund, Meza-Zepeda, Leonardo, Munthe-Kaas, Monica Cheng, Nguyen, Olav Toai Duc, Niehusmann, Pitt, Nilsen, Hilde, Puco, Katarina, Ree, Anne Hansen, Riste, Tonje Bøyum, Semb, Karin, Steinskog, Eli Sihn Samdal, Stensvold, Andreas, Suhrke, Pål, Tennøe, Øyvind, Tjønnfjord, Geir E., Vassbotn, Liv Jorunn, Aas, Eline, Aasebø, Kristine, Tasken, Kjetil, and Smeland, Sigbjørn

Published
2022
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8. Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium

Author

Felix, Janine F, Joubert, Bonnie R, Baccarelli, Andrea A, Sharp, Gemma C, Almqvist, Catarina, Annesi-Maesano, Isabella, Arshad, Hasan, Baïz, Nour, Bakermans-Kranenburg, Marian J, Bakulski, Kelly M, Binder, Elisabeth B, Bouchard, Luigi, Breton, Carrie V, Brunekreef, Bert, Brunst, Kelly J, Burchard, Esteban G, Bustamante, Mariona, Chatzi, Leda, Munthe-Kaas, Monica Cheng, Corpeleijn, Eva, Czamara, Darina, Dabelea, Dana, Smith, George Davey, De Boever, Patrick, Duijts, Liesbeth, Dwyer, Terence, Eng, Celeste, Eskenazi, Brenda, Everson, Todd M, Falahi, Fahimeh, Fallin, M Daniele, Farchi, Sara, Fernandez, Mariana F, Gao, Lu, Gaunt, Tom R, Ghantous, Akram, Gillman, Matthew W, Gonseth, Semira, Grote, Veit, Gruzieva, Olena, Håberg, Siri E, Herceg, Zdenko, Hivert, Marie-France, Holland, Nina, Holloway, John W, Hoyo, Cathrine, Hu, Donglei, Huang, Rae-Chi, Huen, Karen, Järvelin, Marjo-Riitta, Jima, Dereje D, Just, Allan C, Karagas, Margaret R, Karlsson, Robert, Karmaus, Wilfried, Kechris, Katerina J, Kere, Juha, Kogevinas, Manolis, Koletzko, Berthold, Koppelman, Gerard H, Küpers, Leanne K, Ladd-Acosta, Christine, Lahti, Jari, Lambrechts, Nathalie, Langie, Sabine AS, Lie, Rolv T, Liu, Andrew H, Magnus, Maria C, Magnus, Per, Maguire, Rachel L, Marsit, Carmen J, McArdle, Wendy, Melén, Erik, Melton, Phillip, Murphy, Susan K, Nawrot, Tim S, Nisticò, Lorenza, Nohr, Ellen A, Nordlund, Björn, Nystad, Wenche, Oh, Sam S, Oken, Emily, Page, Christian M, Perron, Patrice, Pershagen, Göran, Pizzi, Costanza, Plusquin, Michelle, Raikkonen, Katri, Reese, Sarah E, Reischl, Eva, Richiardi, Lorenzo, Ring, Susan, Roy, Ritu P, Rzehak, Peter, Schoeters, Greet, Schwartz, David A, Sebert, Sylvain, Snieder, Harold, Sørensen, Thorkild IA, and Starling, Anne P

Subjects
Epidemiology, Public Health, Health Sciences, Statistics, Mathematical Sciences, Child Health, Cohort Studies, DNA Methylation, Environmental Pollution, Epigenesis, Genetic, Female, Folic Acid, Humans, Infant, Newborn, Maternal Exposure, Maternal Health, Pregnancy, Prenatal Exposure Delayed Effects, Public Health and Health Services, Public health
Published
2018

9. Genomic characterization of relapsed acute myeloid leukemia reveals novel putative therapeutic targets

Author

Stratmann, Svea, Yones, Sara A., Mayrhofer, Markus, Norgren, Nina, Skaftason, Aron, Sun, Jitong, Smolinska, Karolina, Komorowski, Jan, Herlin, Morten Krogh, Sundström, Christer, Eriksson, Anna, Höglund, Martin, Palle, Josefine, Abrahamsson, Jonas, Jahnukainen, Kirsi, Munthe-Kaas, Monica Cheng, Zeller, Bernward, Tamm, Katja Pokrovskaja, Cavelier, Lucia, and Holmfeldt, Linda

Published
2021
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10. DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis

Author

Joubert, Bonnie R, Felix, Janine F, Yousefi, Paul, Bakulski, Kelly M, Just, Allan C, Breton, Carrie, Reese, Sarah E, Markunas, Christina A, Richmond, Rebecca C, Xu, Cheng-Jian, Küpers, Leanne K, Oh, Sam S, Hoyo, Cathrine, Gruzieva, Olena, Söderhäll, Cilla, Salas, Lucas A, Baïz, Nour, Zhang, Hongmei, Lepeule, Johanna, Ruiz, Carlos, Ligthart, Symen, Wang, Tianyuan, Taylor, Jack A, Duijts, Liesbeth, Sharp, Gemma C, Jankipersadsing, Soesma A, Nilsen, Roy M, Vaez, Ahmad, Fallin, M Daniele, Hu, Donglei, Litonjua, Augusto A, Fuemmeler, Bernard F, Huen, Karen, Kere, Juha, Kull, Inger, Munthe-Kaas, Monica Cheng, Gehring, Ulrike, Bustamante, Mariona, Saurel-Coubizolles, Marie José, Quraishi, Bilal M, Ren, Jie, Tost, Jörg, Gonzalez, Juan R, Peters, Marjolein J, Håberg, Siri E, Xu, Zongli, van Meurs, Joyce B, Gaunt, Tom R, Kerkhof, Marjan, Corpeleijn, Eva, Feinberg, Andrew P, Eng, Celeste, Baccarelli, Andrea A, Neelon, Sara E Benjamin, Bradman, Asa, Merid, Simon Kebede, Bergström, Anna, Herceg, Zdenko, Hernandez-Vargas, Hector, Brunekreef, Bert, Pinart, Mariona, Heude, Barbara, Ewart, Susan, Yao, Jin, Lemonnier, Nathanaël, Franco, Oscar H, Wu, Michael C, Hofman, Albert, McArdle, Wendy, Van der Vlies, Pieter, Falahi, Fahimeh, Gillman, Matthew W, Barcellos, Lisa F, Kumar, Ashish, Wickman, Magnus, Guerra, Stefano, Charles, Marie-Aline, Holloway, John, Auffray, Charles, Tiemeier, Henning W, Smith, George Davey, Postma, Dirkje, Hivert, Marie-France, Eskenazi, Brenda, Vrijheid, Martine, Arshad, Hasan, Antó, Josep M, Dehghan, Abbas, Karmaus, Wilfried, Annesi-Maesano, Isabella, Sunyer, Jordi, Ghantous, Akram, Pershagen, Göran, Holland, Nina, Murphy, Susan K, DeMeo, Dawn L, Burchard, Esteban G, Ladd-Acosta, Christine, Snieder, Harold, and Nystad, Wenche

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Health Sciences, Genetics, Human Genome, Prevention, Tobacco Smoke and Health, Tobacco, Perinatal Period - Conditions Originating in Perinatal Period, Pediatric, Clinical Research, 2.1 Biological and endogenous factors, Reproductive health and childbirth, Respiratory, Good Health and Well Being, Asthma, Child, Child, Preschool, Chromosome Mapping, Cleft Lip, Cleft Palate, DNA Methylation, Epigenesis, Genetic, Female, Genetic Association Studies, Humans, Infant, Infant, Newborn, Pregnancy, Smoking, White People, Medical and Health Sciences, Genetics & Heredity, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Epigenetic modifications, including DNA methylation, represent a potential mechanism for environmental impacts on human disease. Maternal smoking in pregnancy remains an important public health problem that impacts child health in a myriad of ways and has potential lifelong consequences. The mechanisms are largely unknown, but epigenetics most likely plays a role. We formed the Pregnancy And Childhood Epigenetics (PACE) consortium and meta-analyzed, across 13 cohorts (n = 6,685), the association between maternal smoking in pregnancy and newborn blood DNA methylation at over 450,000 CpG sites (CpGs) by using the Illumina 450K BeadChip. Over 6,000 CpGs were differentially methylated in relation to maternal smoking at genome-wide statistical significance (false discovery rate, 5%), including 2,965 CpGs corresponding to 2,017 genes not previously related to smoking and methylation in either newborns or adults. Several genes are relevant to diseases that can be caused by maternal smoking (e.g., orofacial clefts and asthma) or adult smoking (e.g., certain cancers). A number of differentially methylated CpGs were associated with gene expression. We observed enrichment in pathways and processes critical to development. In older children (5 cohorts, n = 3,187), 100% of CpGs gave at least nominal levels of significance, far more than expected by chance (p value < 2.2 × 10(-16)). Results were robust to different normalization methods used across studies and cell type adjustment. In this large scale meta-analysis of methylation data, we identified numerous loci involved in response to maternal smoking in pregnancy with persistence into later childhood and provide insights into mechanisms underlying effects of this important exposure.

Published
2016

11. Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence

Author

Choudhary, Priyanka, primary, Monasso, Giulietta S., additional, Karhunen, Ville, additional, Ronkainen, Justiina, additional, Mancano, Giulia, additional, Howe, Caitlin G., additional, Niu, Zhongzheng, additional, Zeng, Xuehuo, additional, Guan, Weihua, additional, Dou, John, additional, Feinberg, Jason I., additional, Mordaunt, Charles, additional, Pesce, Giancarlo, additional, Baïz, Nour, additional, Alfano, Rossella, additional, Martens, Dries S., additional, Wang, Congrong, additional, Isaevska, Elena, additional, Keikkala, Elina, additional, Mustaniemi, Sanna, additional, Thio, Chris H. L., additional, Fraszczyk, Eliza, additional, Tobi, Elmar W., additional, Starling, Anne P., additional, Cosin-Tomas, Marta, additional, Urquiza, Jose, additional, Röder, Stefan, additional, Hoang, Thanh T., additional, Page, Christian, additional, Jima, Dereje D., additional, House, John S., additional, Maguire, Rachel L., additional, Ott, Raffael, additional, Pawlow, Xenia, additional, Sirignano, Lea, additional, Zillich, Lea, additional, Malmberg, Anni, additional, Rauschert, Sebastian, additional, Melton, Phillip, additional, Gong, Tong, additional, Karlsson, Robert, additional, Fore, Ruby, additional, Perng, Wei, additional, Laubach, Zachary M., additional, Czamara, Darina, additional, Sharp, Gemma, additional, Breton, Carrie V., additional, Schisterman, Enrique, additional, Yeung, Edwina, additional, Mumford, Sunni L., additional, Fallin, M. Daniele, additional, LaSalle, Janine M., additional, Schmidt, Rebecca J., additional, Bakulski, Kelly M., additional, Annesi-Maesano, Isabella, additional, Heude, Barbara, additional, Nawrot, Tim S., additional, Plusquin, Michelle, additional, Ghantous, Akram, additional, Herceg, Zdenko, additional, Nisticò, Lorenza, additional, Vafeiadi, Marina, additional, Kogevinas, Manolis, additional, Vääräsmäki, Marja, additional, Kajantie, Eero, additional, Snieder, Harold, additional, Corpeleijn, Eva, additional, Steegers-Theunissen, Regine P. M., additional, Yang, Ivana V., additional, Dabelea, Dana, additional, Fossati, Serena, additional, Zenclussen, Ana C., additional, Herberth, Gunda, additional, Magnus, Maria, additional, Håberg, Siri E., additional, London, Stephanie J., additional, Munthe-Kaas, Monica Cheng, additional, Murphy, Susan K., additional, Hoyo, Cathrine, additional, Ziegler, Anette-G, additional, Hummel, Sandra, additional, Witt, Stephanie H., additional, Streit, Fabian, additional, Frank, Josef, additional, Räikkönen, Katri, additional, Lahti, Jari, additional, Huang, Rae-chi, additional, Almqvist, Catarina, additional, Hivert, Marie-France, additional, Jaddoe, Vincent W. V., additional, Järvelin, Marjo-Riitta, additional, Kantomaa, Marko, additional, Felix, Janine F., additional, and Sebert, Sylvain, additional

Published
2023
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12. Abstract LB362: Epigenome-wide DNA methylation alterations precede diagnosis since birth and affect prognosis of pediatric B-cell acute lymphoblastic leukemia

Author

Ghantous, Akram, primary, Nusslé, Semira Gonseth, additional, Nassar, Farah, additional, Spitz, Natalia, additional, Novoloaca, Alexei, additional, Krali, Olga, additional, Roy, Ritu, additional, Li, Shaobo, additional, Caron, Maxime, additional, Lam, Lilys, additional, Fransquet, Peter Daniel, additional, Casement, John, additional, Strathdee, John, additional, Pearce, Mark S., additional, Hansen, Helen M., additional, De Smith, Adam J., additional, Sinnett, Daniel, additional, Håberg, Siri Eldevik, additional, McKay, Jill, additional, Nordlund, Jessica, additional, Magnus, Per, additional, Dwyer, Terence, additional, Saffery, Richard, additional, Wiemels, Joseph Leo, additional, Munthe-Kaas, Monica Cheng, additional, and Herceg, Zdenko, additional

Published
2023
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13. Proteogenomic analysis of acute myeloid leukemia associates relapsed disease with reprogrammed energy metabolism both in adults and children

Author

Stratmann, Svea, primary, Vesterlund, Mattias, additional, Umer, Husen M., additional, Eshtad, Saeed, additional, Skaftason, Aron, additional, Herlin, Morten Krogh, additional, Sundström, Christer, additional, Eriksson, Anna, additional, Höglund, Martin, additional, Palle, Josefine, additional, Abrahamsson, Jonas, additional, Jahnukainen, Kirsi, additional, Munthe-Kaas, Monica Cheng, additional, Zeller, Bernward, additional, Tamm, Katja Pokrovskaja, additional, Lindskog, Cecilia, additional, Cavelier, Lucia, additional, Lehtiö, Janne, additional, and Holmfeldt, Linda, additional

Published
2022
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14. The ECHO recommendations for dealing with vinblastine shortage affecting standard treatment of systemic Langerhans cell histiocytosis.

Author

Papadakis, Vassilios, Astigarraga, Itziar, van den Bos, Cor, Donadieu, Jean, Henter, Jan‐Inge, Jacobs, Sandra, Lehrnbecher, Thomas, Munthe‐Kaas, Monica Cheng, Naeije, Leonie, Nanduri, Vasanta, Nguyen, Trung, Nysom, Karsten, Pears, Jane, Raciborska, Anna, Sieni, Elena, Svojgr, Karel, Tzotzola, Vasiliki, and Minkov, Milen

Published
2024
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15. Improving public cancer care by implementing precision medicine in Norway - IMPRESS-Norway

Author

Helland, Åslaug, primary, Russnes, Hege G, additional, Fagereng, Gro Live Live, additional, Al-Shibli, Khalid, additional, Andersson, Yvonne, additional, Berg, Thomas, additional, Bjørge, Line, additional, Blix, Egil, additional, Bjerkehagen, Bodil, additional, Brabrand, Sigmund, additional, Cameron, Marte Grønlie, additional, Dalhaug, Astrid, additional, Dietzel, Dalia, additional, Dønnem, Tom, additional, Enerly, Espen, additional, Flobak, Åsmund, additional, Fluge, Sverre, additional, Gilje, Bjørnar, additional, Gjertsen, Bjørn Tore, additional, Grønberg, Bjørn Henning, additional, Grønås, Kari, additional, Guren, Tormod, additional, Hamre, Hanne, additional, Haug, Åse, additional, Heinrich, Daniel, additional, Hjortland, Geir Olav, additional, Hovig, Eivind, additional, Hovland, Randi, additional, Iversen, Ann-Charlotte, additional, Janssen, Emiel, additional, Kyte, Jon Amund, additional, Gythfeldt, Hedda von der Lippe, additional, Lothe, Ragnhild, additional, Lund, Jo-Åsmund, additional, Meza-Zepeda, Leonardo, additional, Munthe-Kaas, Monica Cheng, additional, Nguyen, Olav Toai Duc, additional, Niehusmann, Pitt, additional, Nilsen, Hilde, additional, Puco, Katarina, additional, Ree, Anne Hansen, additional, Riste, Tonje Bøyum, additional, Semb, Karin, additional, Steinskog, Eli Sihn Samdal, additional, Stensvold, Andreas, additional, Suhrke, Pål, additional, Tennøe, Øyvind, additional, Tjønnfjord, Geir, additional, Vassbotn, Liv Jorunn, additional, Aas, Eline, additional, Aasebø, Kristine, additional, Taskén, Kjetil, additional, and Smeland, Sigbjørn, additional

Published
2022
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18. SUPPLEMENTARY MATERIAL: Transcriptomic analysis reveals pro-inflammatory signatures associated with acute myeloid leukemia progression

Author

Stratmann, Svea, Yones, Sara A., Garbulowski, Mateusz, Sun, Jitong, Skaftason, Aron, Mayrhofer, Markus, Norgren, Nina, Herlin, Morten Krogh, Sundström, Christer, Eriksson, Anna, Höglund, Martin, Palle, Josefine, Abrahamsson, Jonas, Jahnukainen, Kirsi, Munthe-Kaas, Monica Cheng, Zeller, Bernward, Tamm, Katja Pokrovskaja, Cavelier, Lucia, Komorowski, Jan, Holmfeldt, Linda, Stratmann, Svea, Yones, Sara A., Garbulowski, Mateusz, Sun, Jitong, Skaftason, Aron, Mayrhofer, Markus, Norgren, Nina, Herlin, Morten Krogh, Sundström, Christer, Eriksson, Anna, Höglund, Martin, Palle, Josefine, Abrahamsson, Jonas, Jahnukainen, Kirsi, Munthe-Kaas, Monica Cheng, Zeller, Bernward, Tamm, Katja Pokrovskaja, Cavelier, Lucia, Komorowski, Jan, and Holmfeldt, Linda

Published
2021

19. Reduced lung function at birth and the risk of asthma at 10 years of age

Author

Haland, Geir, Carlsen, Karin C. Lodrup, Sandvik, Leiv, Devulapalli, Chandra Sekhar, Munthe-Kaas, Monica Cheng, Pettersen, Morten, and Carlsen, Kai-Hakon

Subjects
Asthma -- Risk factors, Asthma -- Health aspects, Asthma in children -- Risk factors, Asthma in children -- Health aspects
Abstract

A prospective birth cohort study of healthy infants is conducted in which the lung function is measured shortly after birth in order to assess whether reduced lung function shortly after birth predicts asthma 10 years later. The results have concluded that reduced lung function at birth is associated with an increased risk of asthma by 10 years of age.

Published
2006

23. Therapy-induced Deletion in 11q23 Leading to Fusion of KMT2A With ARHGEF12 and Development of B Lineage Acute Lymphoplastic Leukemia in a Child Treated for Acute Myeloid Leukemia Caused by t(9;11)(p21;q23)/KMT2A-MLLT3

Author

PANAGOPOULOS, IOANNIS, primary, ANDERSEN, KRISTIN, additional, EILERT-OLSEN, MARTINE, additional, ZELLER, BERNWARD, additional, MUNTHE-KAAS, MONICA CHENG, additional, BUECHNER, JOCHEN, additional, OSNES, LIV T.N., additional, MICCI, FRANCESCA, additional, and HEIM, SVERRE, additional

Published
2021
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28. Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

Author

Sikdar, Sinjini, primary, Joehanes, Roby, additional, Joubert, Bonnie R, additional, Xu, Cheng-Jian, additional, Vives-Usano, Marta, additional, Rezwan, Faisal I, additional, Felix, Janine F, additional, Ward, James M, additional, Guan, Weihua, additional, Richmond, Rebecca C, additional, Brody, Jennifer A, additional, Küpers, Leanne K, additional, Baïz, Nour, additional, Håberg, Siri E, additional, Smith, Jennifer A, additional, Reese, Sarah E, additional, Aslibekyan, Stella, additional, Hoyo, Cathrine, additional, Dhingra, Radhika, additional, Markunas, Christina A, additional, Xu, Tao, additional, Reynolds, Lindsay M, additional, Just, Allan C, additional, Mandaviya, Pooja R, additional, Ghantous, Akram, additional, Bennett, Brian D, additional, Wang, Tianyuan, additional, Consortium, The BIOS, additional, Bakulski, Kelly M, additional, Melen, Erik, additional, Zhao, Shanshan, additional, Jin, Jianping, additional, Herceg, Zdenko, additional, Meurs, Joyce van, additional, Taylor, Jack A, additional, Baccarelli, Andrea A, additional, Murphy, Susan K, additional, Liu, Yongmei, additional, Munthe-Kaas, Monica Cheng, additional, Deary, Ian J, additional, Nystad, Wenche, additional, Waldenberger, Melanie, additional, Annesi-Maesano, Isabella, additional, Conneely, Karen, additional, Jaddoe, Vincent WV, additional, Arnett, Donna, additional, Snieder, Harold, additional, Kardia, Sharon LR, additional, Relton, Caroline L, additional, Ong, Ken K, additional, Ewart, Susan, additional, Moreno-Macias, Hortensia, additional, Romieu, Isabelle, additional, Sotoodehnia, Nona, additional, Fornage, Myriam, additional, Motsinger-Reif, Alison, additional, Koppelman, Gerard H, additional, Bustamante, Mariona, additional, Levy, Daniel, additional, and London, Stephanie J, additional

Published
2019
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29. Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

Author

Sikdar, Sinjini, Joehanes, Roby, Joubert, Bonnie R., Xu, Cheng Jian, Vives-Usano, Marta, Rezwan, Faisal I., Felix, Janine F., Ward, James M., Guan, Weihua, Richmond, Rebecca C., Brody, Jennifer A., Küpers, Leanne K., Baïz, Nour, Håberg, Siri E., Smith, Jennifer A., Reese, Sarah E., Aslibekyan, Stella, Hoyo, Cathrine, Dhingra, Radhika, Markunas, Christina A., Xu, Tao, Reynolds, Lindsay M., Just, Allan C., Mandaviya, Pooja R., Ghantous, Akram, Bennett, Brian D., Wang, Tianyuan, Consortium, The Bios, Bakulski, Kelly M., Melen, Erik, Zhao, Shanshan, Jin, Jianping, Herceg, Zdenko, Van Meurs, Joyce, Taylor, Jack A., Baccarelli, Andrea A., Murphy, Susan K., Liu, Yongmei, Munthe-Kaas, Monica Cheng, Deary, Ian J., Nystad, Wenche, Waldenberger, Melanie, Annesi-Maesano, Isabella, Conneely, Karen, Jaddoe, Vincent W.V., Arnett, Donna, Snieder, Harold, Kardia, Sharon L.R., Relton, Caroline L., Ong, Ken K., Ewart, Susan, Moreno-Macias, Hortensia, Romieu, Isabelle, Sotoodehnia, Nona, Fornage, Myriam, Motsinger-Reif, Alison, Koppelman, Gerard H., Bustamante, Mariona, Levy, Daniel, London, Stephanie J., Sikdar, Sinjini, Joehanes, Roby, Joubert, Bonnie R., Xu, Cheng Jian, Vives-Usano, Marta, Rezwan, Faisal I., Felix, Janine F., Ward, James M., Guan, Weihua, Richmond, Rebecca C., Brody, Jennifer A., Küpers, Leanne K., Baïz, Nour, Håberg, Siri E., Smith, Jennifer A., Reese, Sarah E., Aslibekyan, Stella, Hoyo, Cathrine, Dhingra, Radhika, Markunas, Christina A., Xu, Tao, Reynolds, Lindsay M., Just, Allan C., Mandaviya, Pooja R., Ghantous, Akram, Bennett, Brian D., Wang, Tianyuan, Consortium, The Bios, Bakulski, Kelly M., Melen, Erik, Zhao, Shanshan, Jin, Jianping, Herceg, Zdenko, Van Meurs, Joyce, Taylor, Jack A., Baccarelli, Andrea A., Murphy, Susan K., Liu, Yongmei, Munthe-Kaas, Monica Cheng, Deary, Ian J., Nystad, Wenche, Waldenberger, Melanie, Annesi-Maesano, Isabella, Conneely, Karen, Jaddoe, Vincent W.V., Arnett, Donna, Snieder, Harold, Kardia, Sharon L.R., Relton, Caroline L., Ong, Ken K., Ewart, Susan, Moreno-Macias, Hortensia, Romieu, Isabelle, Sotoodehnia, Nona, Fornage, Myriam, Motsinger-Reif, Alison, Koppelman, Gerard H., Bustamante, Mariona, Levy, Daniel, and London, Stephanie J.

Abstract

Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.

Published
2019

30. Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium

Author

Felix, Janine F., Joubert, Bonnie R., Baccarelli, Andrea A., Sharp, Gemma C., Almqvist, Catarina, Annesi-Maesano, Isabella, Arshad, Hasan, Baïz, Nour, Bakermans-Kranenburg, Marian J., Bakulski, Kelly M., Binder, Elisabeth B., Bouchard, Luigi, Breton, Carrie V., Brunekreef, Bert, Brunst, Kelly J., Burchard, Esteban G., Bustamante, Mariona, Chatzi, Leda, Munthe-Kaas, Monica Cheng, Corpeleijn, Eva, Czamara, Darina, Dabelea, Dana, Smith, George Davey, De Boever, Patrick, Duijts, Liesbeth, Dwyer, Terence, Eng, Celeste, Eskenazi, Brenda, Everson, Todd M., Falahi, Fahimeh, Fallin, M. Daniele, Farchi, Sara, Fernández, Mariana F., Gao, Lu, Gaunt, Tom R., Ghantous, Akram, Gillman, Matthew W., Gonseth, Semira, Grote, Veit, Gruzieva, Olena, Håberg, Siri Eldevik, Herceg, Zdenko, Hivert, Marie-France, Holland, Nina, Holloway, John W., Hoyo, Cathrine, Hu, Donglei, Huang, Rae-Chi, Huen, Karen, Järvelin, Marjo-Riitta, Jima, Dereje D., Just, Allan C., Karagas, Margaret R., Magnus, Per, Nystad, Wenche, Page, Christian, Lie, Rolv T., and Magnus, Maria Christine

Abstract

publishedVersion

Published
2018

32. DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis

Author

dIRAS RA-2, Risk Assessment, Joubert, Bonnie R, Felix, Janine F, Yousefi, Paul, Bakulski, Kelly M, Just, Allan C, Breton, Carrie, Reese, Sarah E, Markunas, Christina A, Richmond, Rebecca C, Xu, Cheng-Jian, Küpers, Leanne K, Oh, Sam S, Hoyo, Cathrine, Gruzieva, Olena, Söderhäll, Cilla, Salas, Lucas A, Baïz, Nour, Zhang, Hongmei, Lepeule, Johanna, Ruiz, Carlos, Ligthart, Symen, Wang, Tianyuan, Taylor, Jack A, Duijts, Liesbeth, Sharp, Gemma C, Jankipersadsing, Soesma A, Nilsen, Roy M, Vaez, Ahmad, Fallin, M Daniele, Hu, Donglei, Litonjua, Augusto A, Fuemmeler, Bernard F, Huen, Karen, Kere, Juha, Kull, Inger, Munthe-Kaas, Monica Cheng, Gehring, Ulrike, Bustamante, Mariona, Saurel-Coubizolles, Marie José, Quraishi, Bilal M, Ren, Jie, Tost, Jörg, Gonzalez, Juan R, Peters, Marjolein J, Håberg, Siri E, Xu, Zongli, van Meurs, Joyce B, Gaunt, Tom R, Kerkhof, Marjan, Corpeleijn, Eva, Feinberg, Andrew P, Eng, Celeste, Baccarelli, Andrea A, Benjamin Neelon, Sara E, Bradman, Asa, Merid, Simon Kebede, Bergström, Anna, Herceg, Zdenko, Hernandez-Vargas, Hector, Brunekreef, Bert, Pinart, Mariona, Heude, Barbara, Ewart, Susan, Yao, Jin, Lemonnier, Nathanaël, Franco, Oscar H, Wu, Michael C, Hofman, Albert, McArdle, Wendy, Van der Vlies, Pieter, Falahi, Fahimeh, Gillman, Matthew W, Barcellos, Lisa F, Kumar, Ashish, Wickman, Magnus, Guerra, Stefano, Charles, Marie-Aline, Holloway, John, Auffray, Charles, Tiemeier, Henning W, Smith, George Davey, Postma, Dirkje, Hivert, Marie-France, Eskenazi, Brenda, Vrijheid, Martine, Arshad, Hasan, Antó, Josep M, Dehghan, Abbas, Karmaus, Wilfried, Annesi-Maesano, Isabella, Sunyer, Jordi, Ghantous, Akram, Pershagen, Göran, Holland, Nina, Murphy, Susan K, DeMeo, Dawn L, Burchard, Esteban G, Ladd-Acosta, Christine, Snieder, Harold, Nystad, Wenche, Koppelman, Gerard H, Relton, Caroline L, Jaddoe, Vincent W V, Wilcox, Allen, Melén, Erik, London, Stephanie J, dIRAS RA-2, Risk Assessment, Joubert, Bonnie R, Felix, Janine F, Yousefi, Paul, Bakulski, Kelly M, Just, Allan C, Breton, Carrie, Reese, Sarah E, Markunas, Christina A, Richmond, Rebecca C, Xu, Cheng-Jian, Küpers, Leanne K, Oh, Sam S, Hoyo, Cathrine, Gruzieva, Olena, Söderhäll, Cilla, Salas, Lucas A, Baïz, Nour, Zhang, Hongmei, Lepeule, Johanna, Ruiz, Carlos, Ligthart, Symen, Wang, Tianyuan, Taylor, Jack A, Duijts, Liesbeth, Sharp, Gemma C, Jankipersadsing, Soesma A, Nilsen, Roy M, Vaez, Ahmad, Fallin, M Daniele, Hu, Donglei, Litonjua, Augusto A, Fuemmeler, Bernard F, Huen, Karen, Kere, Juha, Kull, Inger, Munthe-Kaas, Monica Cheng, Gehring, Ulrike, Bustamante, Mariona, Saurel-Coubizolles, Marie José, Quraishi, Bilal M, Ren, Jie, Tost, Jörg, Gonzalez, Juan R, Peters, Marjolein J, Håberg, Siri E, Xu, Zongli, van Meurs, Joyce B, Gaunt, Tom R, Kerkhof, Marjan, Corpeleijn, Eva, Feinberg, Andrew P, Eng, Celeste, Baccarelli, Andrea A, Benjamin Neelon, Sara E, Bradman, Asa, Merid, Simon Kebede, Bergström, Anna, Herceg, Zdenko, Hernandez-Vargas, Hector, Brunekreef, Bert, Pinart, Mariona, Heude, Barbara, Ewart, Susan, Yao, Jin, Lemonnier, Nathanaël, Franco, Oscar H, Wu, Michael C, Hofman, Albert, McArdle, Wendy, Van der Vlies, Pieter, Falahi, Fahimeh, Gillman, Matthew W, Barcellos, Lisa F, Kumar, Ashish, Wickman, Magnus, Guerra, Stefano, Charles, Marie-Aline, Holloway, John, Auffray, Charles, Tiemeier, Henning W, Smith, George Davey, Postma, Dirkje, Hivert, Marie-France, Eskenazi, Brenda, Vrijheid, Martine, Arshad, Hasan, Antó, Josep M, Dehghan, Abbas, Karmaus, Wilfried, Annesi-Maesano, Isabella, Sunyer, Jordi, Ghantous, Akram, Pershagen, Göran, Holland, Nina, Murphy, Susan K, DeMeo, Dawn L, Burchard, Esteban G, Ladd-Acosta, Christine, Snieder, Harold, Nystad, Wenche, Koppelman, Gerard H, Relton, Caroline L, Jaddoe, Vincent W V, Wilcox, Allen, Melén, Erik, and London, Stephanie J

Published
2016

35. Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

Author

Sikdar, Sinjini, Joehanes, Roby, Joubert, Bonnie R, Xu, Cheng-Jian, Vives-Usano, Marta, Rezwan, Faisal I, Felix, Janine F, Ward, James M, Guan, Weihua, Richmond, Rebecca C, Brody, Jennifer A, Küpers, Leanne K, Baïz, Nour, Håberg, Siri E, Smith, Jennifer A, Reese, Sarah E, Aslibekyan, Stella, Hoyo, Cathrine, Dhingra, Radhika, Markunas, Christina A, Xu, Tao, Reynolds, Lindsay M, Just, Allan C, Mandaviya, Pooja R, Ghantous, Akram, Bennett, Brian D, Wang, Tianyuan, Consortium, The Bios, Bakulski, Kelly M, Melen, Erik, Zhao, Shanshan, Jin, Jianping, Herceg, Zdenko, Meurs, Joyce Van, Taylor, Jack A, Baccarelli, Andrea A, Murphy, Susan K, Liu, Yongmei, Munthe-Kaas, Monica Cheng, Deary, Ian J, Nystad, Wenche, Waldenberger, Melanie, Annesi-Maesano, Isabella, Conneely, Karen, Jaddoe, Vincent Wv, Arnett, Donna, Snieder, Harold, Kardia, Sharon Lr, Relton, Caroline L, Ong, Ken K, Ewart, Susan, Moreno-Macias, Hortensia, Romieu, Isabelle, Sotoodehnia, Nona, Fornage, Myriam, Motsinger-Reif, Alison, Koppelman, Gerard H, Bustamante, Mariona, Levy, Daniel, and London, Stephanie J

Subjects
Adult, Epigenomics, epigenetics, Infant, Newborn, cigarette smoking, DNA Methylation, infant, 3. Good health, Epigenesis, Genetic, Cohort Studies, Maternal Exposure, Pregnancy, Prenatal Exposure Delayed Effects, Tobacco Smoking, Humans, CpG Islands, Female, methylation
Abstract

Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.

36. Reduced Lung Function at Birth and the Risk of Asthma at 10 Years of Age.

Author

Håland, Geir, Carlsen, Karin C. Lødrup, Sandvik, Leiv, Devulapalli, Chandra Sekhar, Munthe-Kaas, Monica Cheng, Pettersen, Morten, and Carlsen, Kai-Håkon

Subjects
*ASTHMA in children, *PULMONARY function tests, *INFANTS, *INFANT health, *BRONCHIAL spasm, *OBSTRUCTIVE lung diseases, *RESPIRATORY organs, *ASTHMA risk factors
Abstract

Background: Reduced lung function in early infancy has been associated with later obstructive airway diseases. We assessed whether reduced lung function shortly after birth predicts asthma 10 years later. Methods: We conducted a prospective birth cohort study of healthy infants in which we measured lung function shortly after birth with the use of tidal breathing flow-volume loops (the fraction of expiratory time to peak tidal expiratory flow to total expiratory time [tPTEF/tE]) in 802 infants and passive respiratory mechanics, including respiratory-system compliance, in 664 infants. At 10 years of age, 616 children (77%) were reassessed by measuring lung function, exercise-induced bronchoconstriction, and bronchial hyperresponsiveness (by means of a methacholine challenge) and by conducting a structured interview to determine whether there was a history of asthma or current asthma. Results: As compared with children whose tPTEF/tE shortly after birth was above the median, children whose tPTEF/tE was at or below the median were more likely at 10 years of age to have a history of asthma (24.3% vs. 16.2%, P=0.01), to have current asthma (14.6% vs. 7.5%, P=0.005), and to have severe bronchial hyperresponsiveness, defined as a methacholine dose of less than 1.0 μmol causing a 20% fall in the forced expiratory volume in 1 second (FEV1) (9.1% vs. 4.9%, P=0.05). As compared with children whose respiratory-system compliance was above the median, children with respiratory compliance at or below the median more often had a history of asthma (27.4% vs. 14.8%; P=0.001) and current asthma (15.0% vs. 7.7%, P=0.009), although this measure was not associated with later measurements of lung function. At 10 years of age, tPTEF/tE at birth correlated weakly with the maximal midexpiratory flow rate (r=0.10, P=0.01) but not with FEV1 or forced vital capacity. Conclusions: Reduced lung function at birth is associated with an increased risk of asthma by 10 years of age. N Engl J Med 2006;355:1682-9. [ABSTRACT FROM AUTHOR]

Published
2006
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37. Rare KMT2A-ELL and Novel ZNF56-KMT2A Fusion Genes in Pediatric T-cell Acute Lymphoblastic Leukemia.

Author

Panagopoulos I, Andersen K, Eilert-Olsen M, Rognlien AG, Munthe-Kaas MC, Micci F, and Heim S

Subjects
Adolescent, Humans, Male, Histone-Lysine N-Methyltransferase metabolism, Myeloid-Lymphoid Leukemia Protein metabolism, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma genetics
Abstract

Background/aim: Previous reports have associated the KMT2A-ELL fusion gene, generated by t(11;19)(q23;p13.1), with acute myeloid leukemia (AML). We herein report a KMT2A-ELL and a novel ZNF56-KMT2A fusion genes in a pediatric T-lineage acute lymphoblastic leukemia (T-ALL)., Materials and Methods: Genetic investigations were performed on bone marrow of a 13-year-old boy diagnosed with T-ALL., Results: A KMT2A-ELL and a novel ZNF56-KMT2A fusion genes were generated on der(11)t(11;19)(q23;p13.1) and der(19)t(11;19)(q23;p13.1), respectively. Exon 20 of KMT2A fused to exon 2 of ELL in KMT2A-ELL chimeric transcript whereas exon 1 of ZNF56 fused to exon 21 of KMT2A in ZNF56-KMT2A transcript. A literature search revealed four more T-ALL patients carrying a KMT2A-ELL fusion. All of them were males aged 11, 11, 17, and 20 years., Conclusion: KMT2A-ELL fusion is a rare recurrent genetic event in T-ALL with uncertain prognostic implications. The frequency and impact of ZNF56-KMT2A in T-ALL are unknown., (Copyright© 2021, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2021
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38. Therapy-induced Deletion in 11q23 Leading to Fusion of KMT2A With ARHGEF12 and Development of B Lineage Acute Lymphoplastic Leukemia in a Child Treated for Acute Myeloid Leukemia Caused by t(9;11)(p21;q23)/ KMT2A-MLLT3 .

Author

Panagopoulos I, Andersen K, Eilert-Olsen M, Zeller B, Munthe-Kaas MC, Buechner J, Osnes LTN, Micci F, and Heim S

Subjects
Child, Chromosomes, Human, Pair 11, Female, Gene Deletion, Gene Fusion, Guanine Nucleotide Exchange Factors genetics, Histone-Lysine N-Methyltransferase genetics, Humans, Leukemia, Myeloid, Acute pathology, Myeloid-Lymphoid Leukemia Protein genetics, Nuclear Proteins genetics, Precursor Cell Lymphoblastic Leukemia-Lymphoma pathology, Leukemia, Myeloid, Acute drug therapy, Leukemia, Myeloid, Acute genetics, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy, Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics
Abstract

Background/aim: Fusion of histone-lysine N-methyltransferase 2A gene (KMT2A) with the Rho guanine nucleotide exchange factor 12 gene (ARHGEF12), both located in 11q23, was reported in some leukemic patients. We report a KMT2A-ARHGEF12 fusion occurring during treatment of a pediatric acute myeloid leukemia (AML) with topoisomerase II inhibitors leading to a secondary acute lymphoblastic leukemia (ALL)., Materials and Methods: Multiple genetic analyses were performed on bone marrow cells of a girl initially diagnosed with AML., Results: At the time of diagnosis with AML, the t(9;11)(p21;q23)/KMT2A-MLLT3 genetic abnormality was found. After chemotherapy resulting in AML clinical remission, a 2 Mb deletion in 11q23 was found generating a KMT2A-ARHGEF12 fusion gene. When the patient later developed B lineage ALL, a t(14;19)(q32;q13), loss of one chromosome 9, and KMT2A-ARHGEF12 were detected., Conclusion: The patient sequentially developed AML and ALL with three leukemia-specific genomic abnormalities in her bone marrow cells, two of which were KMT2A-rearrangements., (Copyright© 2021, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2021
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