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Your search keyword '"Munro, Rory"' showing total 16 results
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16 results on '"Munro, Rory"'

2. Versatile, accessible cross-platform molecular profiling of central nervous system tumors: web-based, prospective multi-center validation

Author

Sahm, Felix, primary, Patel, Areeba, additional, Göbel, Kirsten, additional, Hinz, Felix, additional, Ille, Sebastian, additional, Dogan, Helin, additional, Lomakin, Artem, additional, Schrimpf, Daniel, additional, Göller, Pauline, additional, Ritter, Michael, additional, Kerbs, Paul, additional, Pfeifer, Lisa, additional, Schoebe, Natalie, additional, Hamelmann, Stefan, additional, Blume, Christina, additional, Bogumil, Henri, additional, Berghaus, Natalie, additional, Euskirchen, Philipp, additional, Schweizer, Leonille, additional, Hultschig, Claus, additional, Roy, Nadine Van, additional, Dorpe, Jo Van, additional, Meulen, Joni Van der, additional, Loontiens, Siebe, additional, Dedeurwaerdere, Franceska, additional, Leske, Henning, additional, Halldorsson, Skarphedinn, additional, Fox, Graeme, additional, Deacon, Simon, additional, Cahyani, Inswasti, additional, Holmes, Nadine, additional, Wibowo, Satrio, additional, Munro, Rory, additional, Martin, Dan, additional, Sharif, Abid, additional, Housley, Mark, additional, Goldspring, Robert, additional, Brandner, Sebastian, additional, Roy, Somak, additional, Hench, Jürgen, additional, Frank, Stephan, additional, Unterberg, Andreas, additional, Goidts, Violaine, additional, Jäger, Natalie, additional, Paine, Simon, additional, Smith, Stuart, additional, Herold-Mende, Christel, additional, Wick, Wolfgang, additional, Pfister, Stefan, additional, Krieg, Sandro, additional, Vik-Mo, Einar, additional, von Deimling, Andreas, additional, Jones, David, additional, Loose, Matthew, additional, Schlesner, Matthias, additional, and Sill, Martin, additional

Published
2024
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5. The Stabilization of S100A9 Structure by Calcium Inhibits the Formation of Amyloid Fibrils

Author

Sanders, Ella, primary, Csondor, Rebecca, additional, Šulskis, Darius, additional, Baronaitė, Ieva, additional, Smirnovas, Vytautas, additional, Maheswaran, Luckshi, additional, Horrocks, Jack, additional, Munro, Rory, additional, Georgiadou, Christina, additional, Horvath, Istvan, additional, Morozova-Roche, Ludmilla A., additional, and Williamson, Philip T. F., additional

Published
2023
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7. A framework for real-time monitoring, analysis and adaptive sampling of viral amplicon nanopore sequencing

Author

Munro, Rory, primary, Holmes, Nadine, additional, Moore, Christopher, additional, Carlile, Matthew, additional, Payne, Alexander, additional, Tyson, John R., additional, Williams, Thomas, additional, Alder, Christopher, additional, Snell, Luke B., additional, Nebbia, Gaia, additional, Santos, Roberto, additional, and Loose, Matt, additional

Published
2023
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8. Oligomerization processes limit photoactivation and recovery of the orange carotenoid protein

Author

Andreeva, Elena A., primary, Niziński, Stanisław, additional, Wilson, Adjélé, additional, Levantino, Matteo, additional, De Zitter, Elke, additional, Munro, Rory, additional, Muzzopappa, Fernando, additional, Thureau, Aurélien, additional, Zala, Ninon, additional, Burdzinski, Gotard, additional, Sliwa, Michel, additional, Kirilovsky, Diana, additional, Schirò, Giorgio, additional, and Colletier, Jacques-Philippe, additional

Published
2022
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12. BOSS-RUNS: a flexible and practical dynamic read sampling framework for nanopore sequencing

Author

De Maio, Nicola, Manser, Charlotte, Munro, Rory, Birney, Ewan, Loose, Matthew, and Goldman, Nick

Abstract

Real-time selective sequencing of individual DNA fragments, or ‘Read Until’, allows the focusing of Oxford Nanopore Technology sequencing on pre-selected genomic regions. This can lead to large improvements in DNA sequencing performance in many scenarios where only part of the DNA content of a sample is of interest. This approach is based on the idea of deciding whether to sequence a fragment completely after having sequenced only a small initial part of it. If, based on this small part, the fragment is not deemed of (sufficient) interest it is rejected and sequencing is continued on a new fragment. To date, only simple decision strategies based on location within a genome have been proposed to determine what fragments are of interest. We present a new mathematical model and algorithm for the real-time assessment of the value of prospective fragments. Our decision framework is based not only on which genomic regions are a priori interesting, but also on which fragments have so far been sequenced, and so on the current information available regarding the genome being sequenced. As such, our strategy can adapt dynamically during each run, focusing sequencing efforts in areas of highest uncertainty (typically areas currently low coverage). We show that our approach can lead to considerable savings of time and materials, providing high-confidence genome reconstruction sooner than a standard sequencing run, and resulting in more homogeneous coverage across the genome, even when entire genomes are of interest. Author Summary An existing technique called ‘Read Until’ allows selective sequencing of DNA fragments with an Oxford Nanopore Technology (ONT) sequencer. With Read Until it is possible to enrich coverage of areas of interest within a sequenced genome. We propose a new use of this technique: combining a mathematical model of read utility and an algorithm to select an optimal dynamic decision strategy (i.e. one that can be updated in real time, and so react to the data generated so far in an experiment), we show that it possible to improve the efficiency of a sequencing run by focusing effort on areas of highest uncertainty.

Published
2020
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16. minoTour, real-time monitoring and analysis for nanopore sequencers.

Author

Munro, Rory, Santos, Roberto, Payne, Alexander, Forey, Teri, Osei, Solomon, Holmes, Nadine, and Loose, Matthew

Subjects
*LABORATORY management, *NANOPORES, *SOURCE code, *STEVEDORES
Abstract

Summary minoTour offers a Laboratory Informations Management System (LIMS) system for Oxford Nanopore Technology sequencers, with real-time metrics and analysis available permanently for review. Integration of unique real-time automated analysis can reduce the time required to answer biological questions, including mapping and classification of sequence while a run is in progress. Real-time sequence data require new methods of analysis which do not wait for the completion of a run and minoTour provides a framework to allow users to exploit these features. Availability and implementation Source code and documentation are available at https://github.com/LooseLab/minotourcli and https://github.com/LooseLab/minotourapp. Docker images are available from https://hub.docker.com/r/adoni5/ , and can be installed using a preconfigured docker-compose script at https://github.com/LooseLab/minotour-docker. An example server is available at http://137.44.59.170. Supplementary information Supplementary data are available at Bioinformatics online. [ABSTRACT FROM AUTHOR]

Published
2022
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