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A case of low-grade B-cell malignant lymphoma with a prolonged restriction to the skin is described. A rearrangement of the immunoglobulin heavy-chain gene was detected using molecular techniques. The histology showed many similarities to primary mucosal lymphomas and this may represent a skin counterpart of these tumours. [ABSTRACT FROM AUTHOR]

Spin lattice relaxation time (T1) measured with a low field strength magnetic resonance imager in 51 patients with severe psoriasis did not correlate with the histological findings of liver biopsies taken during treatment with oral methotrexate. Liver T1 measurement at low magnetic field is of no value as a screening procedure in monitoring methotrexate induced liver damage. To try to reduce the frequency of liver biopsies in patients receiving long-term methotrexate for the treatment of psoriasis,1 we sought an alternative, less invasive means of assessing methotrexate induced liver damage. Magnetic resonance imaging (formerly known as nuclear magnetic resonance scanning or NMR) is a non-invasive method of assessing the characteristics of soft tissues. We report here a study to determine the usefulness of the measurement of spin lattice relaxation time (T1) with a low field strength magnetic resonance imager in assessing methotrexate induced liver damage. [ABSTRACT FROM AUTHOR]

The case is described of a patient with a squamous cell carcinoma of the skin of a finger which spread in an unusual manner, caused median nerve compression at the wrist, and infiltrated the median nerve in the forearm. [ABSTRACT FROM AUTHOR]

Forty patients with chronic skin disease who have used potent topical corticosteroids for a prolonged period were studied to determine if adrenal axis suppression had occurred. Thirty-seven cases (92.5%) were normal when the first test was performed and all were normal when retested. Adrenal axis suppression was therefore not of importance in this group of typical outpatients with chronic skin disease. This is an important finding to put into perspective a theoretical rather than a real complication of topical corticosteroid therapy in adults. Absorption of topically applied corticosteroids occurs in normal individuals but especially when the skin is diseased and the integrity of the horny layer of the epidermis is disrupted. The use of occlusive dressings on the skin after topical preparations have been used, greatly enhances penetration, due to increased temperature and humidity of the skin. Many publications demonstrate that virtually all steroid compounds will penetrate the skin, and if enough is absorbed and the compound is potent enough, adrenal axis suppression will occur (Scoggins, 1962; Scholtz & Nelson 1965; Scoggins & Kliman 1965; Munro, Feiwel & James, 1967; James, Munro & Feiwel, 1967). The significance of adrenal axis suppression in relationship to prolonged use of topical corticosteroids by patients suffering from chronic skin disease, has not been adequately investigated. This paper reports a project undertaken to determine whether suppression occurs in patients using corticosteroid topically for control of their skin diseases, as outpatients. [ABSTRACT FROM AUTHOR]

Investigates the effects of clobetasone butyrate, a corticosteroid on pituitary-adrenal axis function and epidermal atrophy of an animal model. Effectiveness of the ointment in patients with eczema; Occurrence of epidermis thinning; Anti-inflammatory activity of clobetasone butyrate.

Reports on a patient who is suffering from severe eczema of the hands due to an orthopaedic plate made of Vitallium. Avoidance of contact with metals; Areas of the body affected by the eczematous eruption; Duration of treatment.

Examines the visceral and skin granuloma annulare lesions in the abdomen. Relationship between diabetes mellitus and granuloma annulare; Association between granuloma annulare and insulin dependent diabetes; Histological condition on the pathogenesis and immune complex deposition.