96 results on '"Munoz-Torrero, Diego"'
Search Results
2. A rhein-huprine hybrid protects erythrocyte membrane integrity against Alzheimer’s disease related Aβ(1-42) peptide
3. From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects
4. A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors
5. First homology model of Plasmodium falciparum glucose-6-phosphate dehydrogenase: Discovery of selective substrate analog-based inhibitors as novel antimalarial agents
6. Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents
7. Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors
8. A fast and specific method to screen for intracellular amyloid inhibitors using bacterial model systems
9. Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity
10. Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal–antiplasmodial activity
11. Shogaol–huprine hybrids: Dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties
12. Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies
13. 1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: Synthesis, pharmacological evaluation and mechanistic studies
14. Huprines as a new family of dual acting trypanocidal–antiplasmodial agents
15. Diastereoselective preparation of ( S)-(1,4,4-trimethylpyrrolidin-3-yl)amine, a new chiral 1,2-diamine for thiourea-type organocatalysts
16. Straightforward preparation of enantiopure 3-amino-4,4-dimethylpyrrolidin-2-one and its derivatives
17. Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates
18. Enantiodivergent synthesis of 3-amino-4,4-dimethyl-1-phenylpyrrolidin-2-one and derivatives: amino analogues of pantolactone
19. Highly diastereoselective one-pot synthesis of spiro{cyclopenta[a]indene-2,2'-indene}diones from 1-indanones and aromatic aldehydes
20. A synthesis of levetiracetam based on ( S)- N-phenylpantolactam as a chiral auxiliary
21. Breakthroughs in medicinal chemistry: new targets and mechanisms, new drugs, new hopes–7, editorial
22. Chapter Six - Multicomponent reactions: A mighty journey partner for infectious tropical disease drug discovery
23. Synthesis of both enantiomers of baclofen using ( R)- and ( S)- N-phenylpantolactam as chiral auxiliaries
24. Stereoselective synthesis of both enantiomers of N-Boc-α-aryl-γ-aminobutyric acids
25. Synthesis of 13-acylamino-huprines: different behavior of diastereomeric 13-methanesulfonamido-huprines on PPA-mediated hydrolysis
26. Synthesis of diastereomeric 13-amido-substituted huprines as potential high affinity acetylcholinesterase inhibitors
27. One-pot synthesis of N-substituted pantolactams from pantolactone
28. Characterisation of the anticholinesterase activity of two new tacrine–huperzine A hybrids
29. Neuroprotective effects of (±)-huprine Y on in vitro and in vivo models of excitoxicity damage
30. On the regioselectivity of the Friedländer reaction leading to huprines: stereospecific acid-promoted isomerization of syn-huprines to their anti-regioisomers
31. The pharmacology of novel acetylcholinesterase inhibitors, (±)-huprines Y and X, on the Torpedo electric organ
32. 6 - Multitarget Anti-Alzheimer Hybrid Compounds: Do They Work In Vivo?
33. Unveiling a novel transient druggable pocket in BACE-1 through molecular simulations: Conformational analysis and binding mode of multisite inhibitors
34. Synthesis of Polysubstituted Bicyclo[3.3.1]nonane-3,7-diones from Cyclohexa-2,5-dienones and Dimethyl 1,3-Acetonedicarboxylate
35. New Syntheses of rac-Huperzine A and its rac-7-Ethyl-Derivative. Evaluation of Several Huperzine A Analogues as Acetylcholinesterase Inhibitors
36. Synthesis and Biological Evaluation of Heteroarylnonanenitriles as Potential Antitrypanosomal Agents: Serendipitous Discovery of Novel Anticholinesterase Hits
37. Synthesis of an 11-unsubstituted analogue of (±)-huperzine A
38. Synthesis and absolute configuration of novel N,O-psiconucleosides using (R)-N-phenylpantolactam as a resolution agent
39. Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines
40. Rhein-Huprine Derivatives Reduce Cognitive Impairment, Synaptic Failure and Amyloid Pathology in A?PPswe/PS-1 Mice of Different Ages
41. SYNTHESIS, PHARMACOLOGICAL EVALUATION, AND MOLECULAR MODELING OF A NOVEL FAMILY OF 6-CHLOROTACRINE-BASED DUAL BINDING SITE ACETYLCHOLINESTERASE INHIBITORS
42. Editorial (Hot Topic: Complexity against Complexity: Multitarget Drugs)
43. ChemInform Abstract: Diastereoselective Preparation of (S)‐(1,4,4‐Trimethylpyrrolidin‐3‐yl)amine, a New Chiral 1,2‐Diamine for Thiourea‐Type Organocatalysts.
44. Structural Determinants of the Multifunctional Profile of Dual Binding Site Acetylcholinesterase Inhibitors as Anti-Alzheimer Agents
45. ChemInform Abstract: Synthesis of 2-Amino-4,6-difluorobenzonitrile: Highly Selective Formation of 5-Fluoro-3-nitro-1,2-benzoquinone 2-Diazide in the Attempted Sandmeyer Cyanation of 2,4-Difluoro-6-nitrobenzenediazonium Cation.
46. ChemInform Abstract: Easy Access to 4-Substituted (.+-.)-Huperzine A Analogues.
47. Editorial:Hot Topic: [Exploiting Multivalency in Drug Design(Executive Editor: Diego Munoz-Torrero)]
48. Editorial [Hot Topic: Alzheimer Drug Design Based on the Amyloid Hypothesis (Executive Editors: D. Munoz-Torrero and P. Camps)]
49. Synthesis and Applications of (R)- and (S)-Pantolactone as Chiral Auxiliaries
50. Preface [Hot Topic: Current Trends in the Development of Acetylcholinesterase Inhibitors as Anti-Alzheimer Agents (Executive Editors: P. Camps and D. Munoz-Torrero)]
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.