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Aim: The aim of the study was to investigate nurses' skill acquisition in Guided Self‐Determination according to the Dreyfus model of skill acquisition and Patricia Benner's studies based on the same model. Background: Globally, person‐centred care is acknowledged as an essential aspect of quality in health care. To succeed with person‐centred care methods and skills are necessary. Guided Self‐Determination is a person‐centred method developed in the field of nursing. The method represents a new way of skill acquisition requiring knowledge of how skills are acquired, unfolded and best supported in Guided Self‐Determination. Design: Qualitative interview study. Method: From January 2019 to August 2019, 16 nurses were interviewed about their experiences of learning and using Guided Self‐Determination in three different gynaecological settings: cancer, endometriosis and sexual abuse. The study was registered with the Danish Data Protection Agency (file no.: VD‐2018‐445, I‐Suite no.: 6700). Results: The spectrum in Guided Self‐Determination acquisition skills ranged from following schematical procedures in a rigorous way to an extended understanding of exploring and supporting the person‐centred concept. Two main themes were identified: Elements in the transition of knowledge from theory to practice and Aspects associated with Guided Self‐Determination skill acquisition. Conclusions: Nurses practised Guided Self‐Determination at different levels. Quantity of practising Guided Self‐Determination was not the only aspect determining rapid progression. The Dreyfus model lacked several explanatory components of skill acquisition, such as personal dispositions, preferences, motivation, personal values and context. [ABSTRACT FROM AUTHOR]