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1. Synergistic impact of innate immunity hyper-activation and endothelial dysfunction on the magnitude of organ failure in the infection-sepsis continuum

Author

de la Fuente, Amanda, López-Sánchez, Jaime, Vaquero-Roncero, Luis Mario, Merino García, María, Sánchez Barrado, María Elisa, Sánchez-Hernández, Miguel Vicente, Garcia-Mateo, Nadia, Rico-Feijoo, Jesús, Muñoz-Bellvís, Luis, González de Castro, Rafael, Tedim, Ana P., Ortega, Alicia, Abdel-lah Fernández, Omar, Suárez-de-la-Rica, Alejandro, Maseda, Emilio, Trejo González, Ignacio, García Carrera, Geovanna Liszeth, Marcos-Vidal, José Miguel, Nieto Arranz, Juan Manuel, Chiscano-Camón, Luis, Ferrer, Ricard, Ruiz-Rodríguez, Juan Carlos, González-López, Juan José, Vila Fernández, José Alberto, Prieto Carballo, Regina, Lopez-Izquierdo, Raul, Garrosa, Sonsoles, Barón, Beatriz, Esteban-Velasco, Carmen, Aldecoa, César, and Bermejo-Martin, Jesús F.

Published
2024
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3. Repeated pancreatic resection for pancreatic metastases from renal cell Carcinoma: A Spanish multicenter study (PANMEKID)

Author

Rojas-Holguín, Adela, Fondevila-Campo, Constantino, Sanjuanbenito, Alfonso, Fabregat-Prous, Joan, Secanella-Medayo, Luís, Rotellar-Sastre, Fernando, Pardo-Sánchez, Fernando, Prieto-Calvo, Mikel, Marín-Ortega, Héctor, Sánchez-Cabús, Santiago, Diez-Valladares, Luis, Alonso-Casado, Óscar, González-Serrano, Carmen, Rodríguez-Sanjuan, Juan Carlos, García-Plaza, Gabriel, Jaén-Torrejimeno, Isabel, Suárez-Muñoz, Miguel Ángel, Becerra-Massare, Antonio, Rio, Paula Senra-del, Pando, Elizabeth, López-Andújar, Rafael, Muñoz-Forner, Elena, Rodriguez-López, Mario, Pereira, Fernando, Serrablo-Requejo, Alejandro, Turrión, Víctor Sánchez, Garrido, Manuel Jiménez, Burdío, Fernando, Martín-Pérez, Elena, Estevan-Estevan, Rafael, López-Guerra, Diego, Castell-Gómez, José, Salinas-Gómez, Javier, López-Baena, José Ángel, López-Ben, Santiago, Solar-García, Lorena, Pérez-Alonso, Alejandro J., Martínez-Insfran, Luis Alberto, Blas, Juan Luis, Cornejo, Marian, Gutierrez-Calvo, Alberto, Pozo, Carlos Domingo-del, Ochando-Cerdan, Federico, Muñoz-Bellvís, Luis, Rebollar-Saenz, José, Sánchez, Belinda, Jover, José María, Gómez-Bravo, Miguel Ángel, Ramia, José M., and Blanco-Fernández, Gerardo

Published
2024
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6. Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial.

Author

Padillo-Ruiz, Javier, Fresno, Cristóbal, Suarez, Gonzalo, Blanco, Gerardo, Muñoz-Bellvis, Luis, Justo, Iago, García-Domingo, Maria I, Ausania, Fabio, Muñoz-Forner, Elena, Serrablo, Alejandro, Martin, Elena, Díez, Luis, Cepeda, Carmen, Marin, Luis, Alamo, Jose, Bernal, Carmen, Pereira, Sheila, Calero, Francisco, Tinoco, Jose, and Paterna, Sandra

Subjects
MESENTERIC artery, PANCREATIC duct, PROGRESSION-free survival, TUMOR surgery, OVERALL survival, PANCREATIC surgery
Abstract

Background Patients with pancreatic ductal adenocarcinoma present early postoperative systemic metastases, despite complete oncological resection. The aim of this study was to assess two pancreatoduodenectomy approaches with regard to intraoperative circulating tumour cells and cluster mobilization and their potential association with the development of distant metastasis. Methods Patients with periampullary tumours who underwent open pancreatoduodenectomy were randomly allocated to either the no-touch approach or the superior mesenteric artery approach. A total of four intraoperative portal vein samples (at the beginning of the intervention, after portal vein disconnection from the tumour, after tumour resection, and before abdominal closure) were collected to measure circulating tumour cells and cluster numbers. Primary outcomes were the intraoperative number of circulating tumour cells and cluster mobilization. Further, their potential impact on 3-year distant metastasis disease-free survival and overall survival was assessed. Results A total of 101 patients with periampullary tumours were randomized (51 in the superior mesenteric artery group and 50 in the no-touch group) and 63 patients with pancreatic ductal adenocarcinoma (34 in the superior mesenteric artery group and 29 in the no-touch group) were analysed. Circulating tumour cells and cluster mobilization were similar in both the no-touch group and the superior mesenteric artery group at all time points. There were no significant differences between surgical groups with regard to the median metastasis disease-free survival (12.4 (interquartile range 6.1–not reached) months in the superior mesenteric artery group and 18.1 (interquartile range 12.1–not reached) months in the no-touch group; P = 0.730). Patients with intraoperative cluster mobilization from the beginning to the end of surgery developed significantly more distant metastases within the first year after surgery (P = 0.023). Two intraoperative factors (the superior mesenteric artery approach (P = 0.025) and vein resection (P < 0.001)) were predictive factors for cluster mobilization. Conclusion Patients undergoing pancreatoduodenectomy using either the no-touch approach or the superior mesenteric artery approach had similar circulating tumour cells and cluster mobilization and similar overall survival and metastasis disease-free survival. A high intraoperative cluster dissemination during pancreatoduodenectomy was a predictive factor for early metastases in patients with pancreatic ductal adenocarcinoma. Registration number NCT03340844 (http://www.clinicaltrials.gov)—CETUPANC trial. [ABSTRACT FROM AUTHOR]

Published
2024
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7. PPAR-γ Gene Expression in Human Adipose Tissue Is Associated with Weight Loss After Sleeve Gastrectomy

Author

Torres, Jorge-Luis, Usategui-Martín, Ricardo, Hernández-Cosido, Lourdes, Bernardo, Edgar, Manzanedo-Bueno, Laura, Hernández-García, Ignacio, Mateos-Díaz, Ana-María, Rozo, Orlando, Matesanz, Nuria, Salete-Granado, Daniel, Chamorro, Antonio-Javier, Carbonell, Cristina, Garcia-Macia, Marina, González-Sarmiento, Rogelio, Sabio, Guadalupe, Muñoz-Bellvís, Luis, and Marcos, Miguel

Published
2022
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10. Executive Summary of the Consensus Statement of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), the Spanish Society of Tropical Medicine and International Health (SEMTSI), the Spanish Association of Surgeons (AEC), the Spanish Society of Pneumology and Thoracic Surgery (SEPAR), the Spanish Society of Thoracic Surgery (SECT), the Spanish Society of Vascular and Interventional Radiology (SERVEI), and the Spanish Society of Paediatric Infectious Diseases (SEIP), on the Management of Cystic Echinococcosis

Author

Belhassen-Garcia, Moncef, Balboa Arregui, Óscar, Calabuig-Muñoz, Eva, Carmena, David, Esteban Velasco, Maria del Carmen, Fuentes Gago, Marta, Fumado Pérez, Victoria, García Alonso, Jesús, García López Hortelano, Milagros, González Fernández, Luis Miguel, Herrero Martínez, Juan María, Iglesias Iglesias, Manuel José, Jiménez López, Marcelo, López-Vélez, Rogelio, Muñoz-Bellvis, Luis, Muro, Antonio, Pardo-Lledías, Javier, Peñaranda-Vera, Maria, Perteguer-Prieto, Maria Jesús, Picado, Albert, Quiñones Sampedro, Jose Edecio, Rodríguez-Guardado, Azucena, Royo Crespo, Íñigo, Salvador, Fernando, Sánchez-Montalvá, Adrian, Torrús Tendero, Diego, and Velasco Pelayo, Luis

Published
2020
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11. Clinical Outcomes After Total Pancreatectomy: A Prospective Multicenter Pan-European Snapshot Study

Author

Latenstein, Anouk E.J., Scholten, Lianne, Al-Saffar, Hasan Ahmad, Björnsson, Bergthor, Butturini, Giovanni, Capretti, Giovanni, Chatzizacharias, Nikolaos A., Dervenis, Chris, Frigerio, Isabella, Gallagher, Tom K., Gasteiger, Silvia, Halimi, Asif, Labori, Knut J., Montagnini, Greta, Muñoz-Bellvis, Luis, Nappo, Gennaro, Nikov, Andrej, Pando, Elizabeth, Pastena, Matteo de, Peña-Moral, Jesús M. de la, Radenkovic, Dejan, Roberts, Keith J., Salvia, Roberto, Sanchez-Bueno, Francisco, Scandavini, Chiara, Serradilla-Martin, Mario, Stättner, Stefan, Tomazic, Ales, Varga, Martin, Zavrtanik, Hana, Zerbi, Alessandro, Erkan, Mert, Kleeff, Jörg, Lesurtel, Mickaël, Besselink, Marc G., and Ramia-Angel, Jose M.

Published
2022
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12. Multicentric Study on Total Pancreatectomies

Author

Fabregat Prous, Joan, Secanella, Lluis, Larrea, Javier, Olea, Sanchez Bueno, Francisco, Botello Martinez, Francisco, Briceño, Javier, Miyar-de León, Alberto, Serradilla, Mario, Serrablo, Alejandro, Ferrer Fabrega, Joana, Sanchez Cabús, S., Angel Gómez Bravo, Miguel, Padillo, Javier, Blanco, Laia, Balcells, J., Cugat, Esteban, García Domingo, Maribel, Muñoz Bellvis, Luis, Dolores Perez Diaz, Maria, Santoyo Santoyo, Julio, Sanchez, Belinda, Villegas, Trinidad, Pacho, Silvino, Díez Valladares, Luis, Rebollar, Jose, Ángel Suárez Muñoz, Miguel, Domínguez, Elías, Martín Perez, Elena, Falgueras, Laia, Poves, Ignasi, Artigas, Vicenç, Sabater, Luis, Garcia Gil, Agustin, Ignacio Miota de Llama, Jose, Manzanet, Gerardo, Carlos Pino, Jose, Carlos Rodríguez Sanjuán, Juan, Lluis, F., Ausania, Fabio, Alkorta Zuloaga, Maialen, Escartín, Jorge, Salas, Manel, Domingo, Carlos, Artigues Sánchez de Rojas, Enrique, Antonio Barreras Mateos, José, María Fernández Cebrián, José, Pérez Cabrera, Beatriz, Padilla Valverde, D., Sanjuanbenito, Alfonso, Iturburu Belmonte, Ignacio, Bejarano, Natalia, García Borobia, F., Toral Guinea, Pablo, Lopez Marcano, Aylhin, Asencio Arana, Francisco, Varo, Evaristo, Esteban, Rafael, Blas, Juan L., Jover Navalón, José M., Fernández Martínez, Cristina, Daban Collado, Enrique, Calvo Duran, Antonio, Vicens, J.C., Romero, J., Badía, J.M., Sánchez, Raquel, de Miguel Ibáñez, Ricardo, Pardoc, Fernando, Francos von Hunefeld, Carlos, Pereira, Fernando, Garcia Molina, Francisco, Rodríguez Prieto, Ignacio, Alonso Poza, Alfredo, Gilsanz, Carlos, Miguel Martínez Albert, Jose, Angel Morcillo, Miguel, Martínez Cortijo, Sagrario, Martín Fernández, José, Baquedano, Jesús, Castell, José, Aguiló, Javier, Carlos Bernal, Juan, Ramia, Jose M., Martin-Perez, Elena, Fabregat-Prous, Joan, Larrea y Olea, Javier, Sanchez-Bueno, Francisco, Botello-Martinez, Francisco, and Moya-Herraiz, Angel

Published
2019
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15. Estudio multicéntrico nacional sobre pancreatectomías totales

Author

Fabregat Prous, Joan, Secanella, Lluis, Larrea y Olea, Javier, Sanchez Bueno, Francisco, Botello Martinez, Francisco, Briceño, Javier, Miyar-de León, Alberto, Serradilla, Mario, Serrablo, Alejandro, Ferrer Fabrega, Joana, Sanchez Cabús, S., Angel Gómez Bravo, Miguel, Padillo, Javier, Blanco, Laia, Balcells, J., Cugat, Esteban, García Domingo, Maribel, Muñoz Bellvis, Luis, Dolores Perez Diaz, Maria, Santoyo Santoyo, Julio, Sanchez, Belinda, Villegas, Trinidad, Pacho, Silvino, Díez Valladares, Luis, Rebollar, Jose, Ángel Suárez Muñoz, Miguel, Domínguez, Elías, Martín Perez, Elena, Falgueras, Laia, Poves, Ignasi, Artigas, Vicenç, Sabater, Luis, Garcia Gil, Agustin, Ignacio Miota de Llama, Jose, Manzanet, Gerardo, Carlos Pino, Jose, Carlos Rodríguez Sanjuán, Juan, Lluis, F., Ausania, Fabio, Alkorta Zuloaga, Maialen, Escartín, Jorge, Salas, Manel, Domingo, Carlos, Artigues Sánchez de Rojas, Enrique, Antonio Barreras Mateos, José, María Fernández Cebrián, José, Pérez Cabrera, Beatriz, Padilla Valverde, D., Sanjuanbenito, Alfonso, Iturburu Belmonte, Ignacio, Bejarano, Natalia, García Borobia, F., Toral Guinea, Pablo, Lopez Marcano, Aylhin, Asencio Arana, Francisco, Varo, Evaristo, Esteban, Rafael, Blas, Juan Laaa, Jover Navalón, José M., Fernández Martínez, Cristina, Daban Collado, Enrique, Calvo Duran, Antonio, Vicens, J.C., Romero, J., Badía, J.M., Sánchez, Raquel, de Miguel Ibáñez, Ricardo, Pardoc, Fernando, Francos von Hunefeld, Carlos, Pereira, Fernando, Garcia Molina, Francisco, Rodríguez Prieto, Ignacio, Alonso Poza, Alfredo, Gilsanz, Carlos, Miguel Martínez Albert, Jose, Angel Morcillo, Miguel, Martínez Cortijo, Sagrario, Martín Fernández, José, Baquedano, Jesús, Castell, José, Aguiló, Javier, Carlos Bernal, Juan, Ramia, Jose M., Martin-Perez, Elena, Fabregat-Prous, Joan, Sanchez-Bueno, Francisco, Botello-Martinez, Francisco, and Moya-Herraiz, Angel

Published
2019
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18. Clinical Outcomes after Total Pancreatectomy: A Prospective Multicenter Pan-European Snapshot Study

Author

Latenstein, Anouk E. J., Scholten, Lianne, Al-Saffar, Hasan Ahmad, Björnsson, Bergthor, Butturini, Giovanni, Capretti, Giovanni, Chatzizacharias, Nikolaos A., Dervenis, Chris, Frigerio, Isabella, Gallagher, Tom K., Gasteiger, Silvia, Halimi, Asif, Labori, Knut J., Montagnini, Greta, Muñoz-Bellvis, Luis, Nappo, Gennaro, Nikov, Andrej, Pando, Elizabeth, de Pastena, Matteo, de la Peña-Moral, Jesús M., Radenkovic, Dejan, Roberts, Keith J., Salvia, Roberto, Sanchez-Bueno, Francisco, Scandavini, Chiara, Serradilla-Martin, Mario, Stättner, Stefan, Tomazic, Ales, Varga, Martin, Zavrtanik, Hana, Zerbi, Alessandro, Erkan, Mert, Kleeff, Jörg, Lesurtel, Mickaël, Besselink, Marc G., and Ramia-Angel, Jose M.

Published
2020
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19. Complement system genetic variability shapes pancreatic cancer risk

Author

Langtry, Alberto, primary, Rabadan, Raul, additional, Alonso, Lola, additional, Lawlor, Rita, additional, Carrato, Alfredo, additional, Hidalgo, María, additional, Iglesias, Mar, additional, Molero, Xavier, additional, Löhr, Matthias, additional, MICHALSKI, Christoph, additional, Perea, José, additional, O'Rorke, Michael, additional, Barberá, Victor Manuel, additional, Tardón, Adonina, additional, Farré, Antoni, additional, Muñoz-Bellvis, Luis, additional, Crnogorac-Jurcevic, Tatjana, additional, Domínguez-Muñoz, Enrique, additional, Gress, Thomas, additional, Greenhalf, William, additional, Sharp, Linda, additional, Filip, Ioan, additional, Sabroso, Sergio, additional, Balsells, Joaquim, additional, Costello, Eithne, additional, Ilzarbe, Lucas, additional, Kleeff, Jórg, additional, Kong, B., additional, Mora, Josefina, additional, O'Driscoll, Damian, additional, Scarpa, Aldo, additional, Ye, Weimin, additional, Yu, J., additional, Real, Francisco X., additional, Malats, Núria, additional, and López de Maturana, Evangelina, additional

Published
2023
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23. Altered Interphase Fluorescence in Situ Hybridization Profiles of Chromosomes 4, 8q24, and 9q34 in Pancreatic Ductal Adenocarcinoma Are Associated with a Poorer Patient Outcome

Author

Gutiérrez, María L., Muñoz-Bellvis, Luis, Sarasquete, María E., Hernández-Mejía, David G., Abad, María del Mar, Bengoechea, Oscar, Corchete, Luis, González-González, María, García-García, Jacinto, Gonzalez, Marcos, Mota, Ines, Orfao, Alberto, and Sayagues, José M.

Published
2014
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31. The protective effect of atopic diseases against pancreatic cancer is not driven by Th2-biomarkers

Author

He, Jiangchuan, Alhamwe, Bilal Alashkar, Sabroso, Sergio, Carrato, Alfredo, Hidalgo, Manuel, Richard, Xavier Molero, Coma, Mar Iglesias, Perea, José, Farré, Antoni, Tardón, Adonina, Dominguez-Muñoz, Enrique, Barberà, Victor, Muñoz-Bellvís, Luís, Löhr, Matthias, Greenhalf, William, O’Rorke, Michael, Gress, Thomas, Crnogorac-Jurcevic, Tatjana, Kleeff, Jörg, Lawlor, Rita, Real, Francisco X., Renz, Harald, and Malats, Núria

Published
2023
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34. Distribution of subsets of blood monocytic cells throughout life

Author

Damasceno, Daniela, Teodosio, Cristina, van den Bossche, Wouter B.L., Perez-Andres, Martín, Arriba-Méndez, Sonia, Muñoz-Bellvis, Luis, Romero, Alfonso, Blanco, Juan F., Remesal, Ana, Puig, Noemi, Matarraz, Sergio, Vicente-Villardón, José Luis, van Dongen, Jacques J.M., Almeida, Julia, and Orfao, Alberto

Published
2019
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35. Serum metabolic biomarkers for the differential diagnosis of distal cholangiocarcinoma and pancreas ductal adenocarcinoma

Author

Macias, Rocio IR, primary, Banales, Jesus M., additional, Gutierrez, Maria Laura, additional, Lapitz, Ainhoa, additional, Muñoz-Bellvis, Luis, additional, La Casta, Adelaida, additional, Arretxe, Enara, additional, Alonso, Cristina, additional, Martínez-Arranz, Ibon, additional, Gonzalez, Luis M., additional, Castro, Rui E., additional, Avila, Matías A, additional, Martínez-Chantar, María Luz, additional, Serrano, Maria, additional, Bujanda, Luis, additional, and Marin, Jose, additional

Published
2020
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36. Pancreatic Cancer Risk in Relation to Lifetime Smoking Patterns, Tobacco Type, and Dose–Response Relationships

Author

Molina-Montes, Esther, primary, Van Hoogstraten, Lisa, additional, Gomez-Rubio, Paulina, additional, Löhr, Matthias, additional, Sharp, Linda, additional, Molero, Xavier, additional, Márquez, Mirari, additional, Michalski, Christoph W., additional, Farré, Antoni, additional, Perea, José, additional, O'Rorke, Michael, additional, Greenhalf, William, additional, Ilzarbe, Lucas, additional, Tardon, Adonina, additional, Gress, Thomas M., additional, Barberà, Victor M., additional, Crnogorac-Jurcevic, Tatjana, additional, Muñoz-Bellvis, Luis, additional, Domínguez-Muñoz, Enrique, additional, Balsells, Joaquim, additional, Costello, Eithne, additional, Iglesias, Mar, additional, Kleeff, Jorg, additional, Kong, Bo, additional, Mora, Josefina, additional, O'Driscoll, Damian, additional, Poves, Ignasi, additional, Scarpa, Aldo, additional, Yu, Jingru, additional, Ye, Weimin, additional, Hidalgo, Manuel, additional, Carrato, Alfredo, additional, Lawlor, Rita, additional, Real, Francisco X., additional, and Malats, Nuria, additional

Published
2020
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37. Resultados de una encuesta sobre el soporte nutricional perioperatorio en la cirugía pancreática y biliar en España

Author

Loinaz, Carmelo, Ochando, Federico, Vicente, Emilio, Serrablo, Alejandro, López Cillero, Pablo, Gómez, Miguel Ángel, Fabregat Prous, Joan, Varo, Evaristo, Miyar de Leon, Albert, Fondevila, Constantino, Valdivieso, Andrés, Blanco, Gerardo, Sánchez, Belinda, López Andújar, Rafael, Fundora, Yilian, Cugat Andorrà, Esteban, Díez Valladares, Luis, Herrera, Javier, García Gil, Agustín, Morales, Rafael, Pardo, Fernando, Sabater, Luis, Baena, José Ángel, Muñoz Bellvis, Luis, Martín Pérez, Elena, Pérez Saborido, Baltasar, Suárez, Miguel Ángel, Meneu, Juan Carlos, Albiol, Maite, Sanjuanbenito, Alfonso, Ramia, José Miguel, Pereira, Fernando, Paseiro, Gloria, Palomo, Juan Carlos, Leon, Miguel, GENPOCIRP (Grupo Encuesta Nutrición PeriOperatoria en CIRugia Pancreatobiliar), UAM. Departamento de Cirugía, and Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP)

Subjects
medicine.medical_specialty, Medicina, Medicine (miscellaneous), Páncreas. Biliar. Cirugía. Nutrición, Nutritional Status, Critical Care and Intensive Care Medicine, Pancreatic head, Biliary surgery, Pancreatic surgery, Pancreatectomy, Surveys and Questionnaires, medicine, Humans, Malalties del pàncrees, Pancreas, Nutrició, Nutrition, Nutrition and Dietetics, Nutritional Support, business.industry, General surgery, Biliary, Guideline, Perioperative, Middle Aged, Biliar, Pancréas diseases, Biliary Tract Surgical Procedures, Páncreas, Solid food, Spain, Nutrición, Surgery, Preoperative fasting, business, Oral feeding
Abstract

Introduction: a survey on peri-operative nutritional support in pancreatic and biliary surgery among Spanish hospitals in 2007 showed that few surgical groups followed the 2006 ESPEN guidelines. Ten years later we sent a questionnaire to check the current situation. Methods: a questionnaire with 21 items sent to 38 centers, related to fasting time before and after surgery, nutritional screening use and type, time and type of peri-operative nutritional support, and number of procedures. Results: thirty-four institutions responded. The median number of pancreatic resections (head/total) was 29.5 (95% CI: 23.0-35; range, 5-68) (total, 1002); of surgeries for biliary malignancies (non-pancreatic), 9.8 (95% CI: 7.3-12.4; range, 2-30); and of main biliary resections for benign conditions, 10.4 (95% CI: 7.6-13.3; range, 2-33). Before surgery, only 41.2% of the sites used nutritional support (< 50% used any nutritional screening procedure). The mean duration of preoperative fasting for solid foods was 9.3 h (range, 6-24 h); it was 6.6 h for liquids (range, 2-12). Following pancreatic surgery, 29.4% tried to use early oral feeding, but 88.2% of the surveyed teams used some nutritional support; 26.5% of respondents used TPN in 100% of cases. Different percentages of TPN and EN were used in the other centers. In malignant biliary surgery, 22.6% used TPN always, and EN in 19.3% of cases. Conclusions: TPN is the commonest nutrition approach after pancreatic head surgery. Only 29.4% of the units used early oral feeding, and 32.3% used EN; 22.6% used TPN regularly after surgery for malignant biliary tumours. The 2006 ESPEN guideline recommendations are not regularly followed 12 years after their publication in our country., Introducción: realizamos una encuesta sobre soporte nutricional perioperatorio en cirugía pancreática y biliar en hospitales españoles en 2007, que mostró que pocos grupos quirúrgicos seguían las guías de ESPEN 2006. Diez años después enviamos un cuestionario para comprobar la situación actual. Métodos: treinta y ocho centros recibieron un cuestionario con 21 preguntas sobre tiempo de ayunas antes y después de la cirugía, cribado nutricional, duración y tipo de soporte nutricional perioperatorio, y número de procedimientos. Resultados: respondieron 34 grupos. La mediana de pancreatectomías (cabeza/total) fue de 29,5 (IC 95 %: 23,0-35; rango, 5-68) (total, 1002), la de cirugías biliares malignas de 9,8 (IC 95 %: 7,3-12,4; rango, 2-30) y la de resecciones biliares por patología benigna de 10,4 (IC 95 %: 7,6-13,3; rango, 2-33). Solo el 41,2 % de los grupos utilizaban soporte nutricional antes de la cirugía (< 50 % habian efectuado un cribado nutricional). El tiempo medio de ayuno preoperatorio para sólidos fue de 9,3 h (rango, 6-24 h), y de 6,6 h para líquidos (rango, 2-12). Tras la pancreatectomía, el 29,4 % habían intentado administrar una dieta oral precoz, pero el 88,2 % de los grupos usaron algún tipo de soporte nutricional y el 26,5 % usaron NP en el 100 % de los casos. Los demás grupos usaron diferentes porcentajes de NP y NE en sus casos. En la cirugía biliar maligna, el 22,6 % utilizaron NP siempre y NE en el 19,3 % de los casos. Conclusiones: la NP es el soporte nutricional más utilizado tras la cirugía de cabeza pancreática. Solo el 29,4 % de las unidades usan nutrición oral precoz y el 32,3 % emplean la NE tras este tipo de cirugía. El 22,6 % de las instituciones usan NP habitualmente tras la cirugía de tumores biliares malignos. Las guías ESPEN 2006 no se siguen de forma habitual en nuestro país tras más de 10 años desde su publicación.

Published
2020

38. Clinical Outcomes after Total Pancreatectomy: A Prospective Multicenter Pan-European Snapshot Study.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de chirurgie, Latenstein, Anouk E J, Scholten, Lianne, Al-Saffar, Hasan Ahmad, Björnsson, Bergthor, Butturini, Giovanni, Capretti, Giovanni, Chatzizacharias, Nikolaos A, Dervenis, Chris, Frigerio, Isabella, Gallagher, Tom K, Gasteiger, Silvia, Halimi, Asif, Labori, Knut J, Montagnini, Greta, Muñoz-Bellvis, Luis, Nappo, Gennaro, Nikov, Andrej, Pando, Elizabeth, de Pastena, Matteo, de la Peña-Moral, Jesús M, Radenkovic, Dejan, Roberts, Keith J, Salvia, Roberto, Sanchez-Bueno, Francisco, Scandavini, Chiara, Serradilla-Martin, Mario, Stättner, Stefan, Tomazic, Ales, Varga, Martin, Zavrtanik, Hana, Zerbi, Alessandro, Erkan, Mert, Kleeff, Jörg, Lesurtel, Mickaël, Besselink, Marc G, Ramia-Angel, Jose M, Scientific, Research Committee of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA), Bertrand, Claude, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de chirurgie, Latenstein, Anouk E J, Scholten, Lianne, Al-Saffar, Hasan Ahmad, Björnsson, Bergthor, Butturini, Giovanni, Capretti, Giovanni, Chatzizacharias, Nikolaos A, Dervenis, Chris, Frigerio, Isabella, Gallagher, Tom K, Gasteiger, Silvia, Halimi, Asif, Labori, Knut J, Montagnini, Greta, Muñoz-Bellvis, Luis, Nappo, Gennaro, Nikov, Andrej, Pando, Elizabeth, de Pastena, Matteo, de la Peña-Moral, Jesús M, Radenkovic, Dejan, Roberts, Keith J, Salvia, Roberto, Sanchez-Bueno, Francisco, Scandavini, Chiara, Serradilla-Martin, Mario, Stättner, Stefan, Tomazic, Ales, Varga, Martin, Zavrtanik, Hana, Zerbi, Alessandro, Erkan, Mert, Kleeff, Jörg, Lesurtel, Mickaël, Besselink, Marc G, Ramia-Angel, Jose M, Scientific, Research Committee of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA), and Bertrand, Claude

Abstract

To assess outcomes among patients undergoing total pancreatectomy (TP) including predictors for complications and in-hospital mortality. Current studies on TP mostly originate from high-volume centers and span long time periods and therefore may not reflect daily practice. This prospective pan-European snapshot study included patients who underwent elective (primary or completion) TP in 43 centers in 16 European countries (June 2018-June 2019). Subgroup analysis included cut-off values for annual volume of pancreatoduodenectomies (<60 vs. ≥60). Predictors for major complications and in-hospital mortality were assessed in multivariable logistic regression. In total, 277 patients underwent TP, mostly for malignant disease (73%). Major postoperative complications occurred in 70 patients (25%). Median hospital stay was 12 days (IQR 9-18) and 40 patients were readmitted (15%). In-hospital mortality was 5% and 90-day mortality 8%. In the subgroup analysis, in-hospital mortality was lower in patients operated in centers with ≥60 pancreatoduodenectomies compared < 60 (4% vs. 10%, p = 0.046). In multivariable analysis, annual volume < 60 pancreatoduodenectomies (OR 3.78, 95%CI 1.18-12.16, p = 0.026), age (OR 1.07, 95%CI 1.01-1.14, p = 0.046), and estimated blood loss ≥2L (OR 11.89, 95%CI 2.64-53.61, p = 0.001) were associated with in-hospital mortality. ASA ≥3 (OR 2.87, 95%CI 1.56-5.26, p = 0.001) and estimated blood loss ≥2L (OR 3.52, 95%CI 1.25-9.90, p = 0.017) were associated with major complications. This pan-European prospective snapshot study found a 5% in-hospital after TP. The identified predictors for mortality, including low-volume centers, age, and increased blood loss, may be used to improve outcomes.

Published
2020

40. Tuberculoma hepático que simula metástasis de carcinoma neuroendocrino gástrico

Author

Anduaga-Peña, María Fernanda, Quiñones-Sampedro, José E., Iglesias-Iglesias, Manuel J., Servide-Staffolani, María José, González-Fernández, Luis Miguel, Esteban-Velasco, María del Carmen, Muñoz-Bellvis, Luis, and Petrone, Patrizio

Subjects
focal nodular hyperplasia, tuberculosis, hiperplasia nodular focal, tuberculoma, tuberculosis hepática, tuberculosis, hepatic, mycobacterium tuberculosis
Abstract

Resumen La tuberculosis es una de las enfermedades infecciosas más frecuentes de distribución mundial, con una amplia presentación clínica. La afectación hepática de la tuberculosis es poco frecuente, pero más infrecuente aún lo es el tuberculoma hepático. Se presenta el caso de una paciente con tuberculoma hepático solitario que simula metástasis hepática secundaria a tumor neuroendocrino. Abstract Tuberculosis is one of the most common infectious diseases, with worldwide distribution and ample clinical manifestations. Hepatic tuberculosis is rare but hepatic tuberculoma is even rarer. We report an unusual case of a solitary hepatic tuberculoma simulating hepatic metastasis of a neuroendocrine tumor.

Published
2018

41. Estudio multicéntrico nacional sobre pancreatectomías totales

Author

Ramia, Jose M., primary, Martin-Perez, Elena, additional, Poves, Ignasi, additional, Fabregat-Prous, Joan, additional, Larrea y Olea, Javier, additional, Sanchez-Bueno, Francisco, additional, Botello-Martinez, Francisco, additional, Briceño, Javier, additional, Miyar-de León, Alberto, additional, Serradilla, Mario, additional, Moya-Herraiz, Angel, additional, Fabregat Prous, Joan, additional, Secanella, Lluis, additional, Sanchez Bueno, Francisco, additional, Botello Martinez, Francisco, additional, Serrablo, Alejandro, additional, Ferrer Fabrega, Joana, additional, Sanchez Cabús, S., additional, Angel Gómez Bravo, Miguel, additional, Padillo, Javier, additional, Blanco, Laia, additional, Balcells, J., additional, Cugat, Esteban, additional, García Domingo, Maribel, additional, Muñoz Bellvis, Luis, additional, Dolores Perez Diaz, Maria, additional, Santoyo Santoyo, Julio, additional, Sanchez, Belinda, additional, Villegas, Trinidad, additional, Pacho, Silvino, additional, Díez Valladares, Luis, additional, Rebollar, Jose, additional, Ángel Suárez Muñoz, Miguel, additional, Domínguez, Elías, additional, Martín Perez, Elena, additional, Falgueras, Laia, additional, Artigas, Vicenç, additional, Sabater, Luis, additional, Garcia Gil, Agustin, additional, Ignacio Miota de Llama, Jose, additional, Manzanet, Gerardo, additional, Carlos Pino, Jose, additional, Carlos Rodríguez Sanjuán, Juan, additional, Lluis, F., additional, Ausania, Fabio, additional, Alkorta Zuloaga, Maialen, additional, Escartín, Jorge, additional, Salas, Manel, additional, Domingo, Carlos, additional, Artigues Sánchez de Rojas, Enrique, additional, Antonio Barreras Mateos, José, additional, María Fernández Cebrián, José, additional, Pérez Cabrera, Beatriz, additional, Padilla Valverde, D., additional, Sanjuanbenito, Alfonso, additional, Iturburu Belmonte, Ignacio, additional, Bejarano, Natalia, additional, García Borobia, F., additional, Toral Guinea, Pablo, additional, Lopez Marcano, Aylhin, additional, Asencio Arana, Francisco, additional, Varo, Evaristo, additional, Esteban, Rafael, additional, Blas, Juan Laaa, additional, Jover Navalón, José M., additional, Fernández Martínez, Cristina, additional, Daban Collado, Enrique, additional, Calvo Duran, Antonio, additional, Vicens, J.C., additional, Romero, J., additional, Badía, J.M., additional, Sánchez, Raquel, additional, de Miguel Ibáñez, Ricardo, additional, Pardoc, Fernando, additional, Francos von Hunefeld, Carlos, additional, Pereira, Fernando, additional, Garcia Molina, Francisco, additional, Rodríguez Prieto, Ignacio, additional, Alonso Poza, Alfredo, additional, Gilsanz, Carlos, additional, Miguel Martínez Albert, Jose, additional, Angel Morcillo, Miguel, additional, Martínez Cortijo, Sagrario, additional, Martín Fernández, José, additional, Baquedano, Jesús, additional, Castell, José, additional, Aguiló, Javier, additional, and Carlos Bernal, Juan, additional

Published
2019
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42. SAT-425-Serum metabolites as diagnostic biomarkers for cholangiocarcinoma, hepatocellular carcinoma and primary sclerosing cholangitis

Author

Banales, Jesús María, primary, Iñarrairaegui, Mercedes, additional, Arbelaiz, Ander, additional, Milkiewicz, Piotr, additional, Muntané, Jordi, additional, Muñoz-Bellvis, Luis, additional, Casta, Adelaida La, additional, Gonzalez, Luis M., additional, Arretxe, Enara, additional, Alonso, Cristina, additional, Martínez-Arranz, Ibon, additional, Lapitz, Ainhoa, additional, Santos-Laso, Alvaro, additional, Avila, Matías A, additional, Martínez-Chantar, María Luz, additional, Bujanda, Luis, additional, Marin, Jose, additional, Sangro, Bruno, additional, and Macias, Rocio IR, additional

Published
2019
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43. Serum Metabolites as Diagnostic Biomarkers for Cholangiocarcinoma, Hepatocellular Carcinoma, and Primary Sclerosing Cholangitis

Author

Medicina, Medikuntza, Bañales Asurmendi, Jesús María, Iñarrairaegui, Mercedes, Arbelaiz Cossio, Ander, Milkiewicz, Piotr, Muntané, Jordi, Muñoz Bellvis, Luis, La Casta, Adelaida, Gonzaz, Luis M., Arretxe Oliden, Enara, Alonso, Cristina, Martínez Arranz, Ibon, Lapitz Dambolenea, Ainhoa, Santos Laso, Álvaro, Avila, Matias A., Martínez Chantar, María Luz, Bujanda Fernández de Pierola, Luis, García Marín, Jose Juan, Sangro, Bruno, Rodríguez Macías, Rocío Isabel, Medicina, Medikuntza, Bañales Asurmendi, Jesús María, Iñarrairaegui, Mercedes, Arbelaiz Cossio, Ander, Milkiewicz, Piotr, Muntané, Jordi, Muñoz Bellvis, Luis, La Casta, Adelaida, Gonzaz, Luis M., Arretxe Oliden, Enara, Alonso, Cristina, Martínez Arranz, Ibon, Lapitz Dambolenea, Ainhoa, Santos Laso, Álvaro, Avila, Matias A., Martínez Chantar, María Luz, Bujanda Fernández de Pierola, Luis, García Marín, Jose Juan, Sangro, Bruno, and Rodríguez Macías, Rocío Isabel

Abstract

Early and differential diagnosis of intrahepatic cholangiocarcinoma (iCCA) and hepatocellular carcinoma (HCC) by noninvasive methods represents a current clinical challenge. The analysis of low-molecular-weight metabolites by new high-throughput techniques is a strategy for identifying biomarkers. Here, we have investigated whether serum metabolome can provide useful biomarkers in the diagnosis of iCCA and HCC and could discriminate iCCA from HCC. Because primary sclerosing cholangitis (PSC) is a risk factor for CCA, serum metabolic profiles of PSC and CCA have also been compared. The analysis of the levels of lipids and amino acids in the serum of patients with iCCA, HCC, and PSC and healthy individuals (n = 20/group) showed differential profiles. Several metabolites presented high diagnostic value for iCCA versus control, HCC versus control, and PSC versus control, with areas under the receiver operating characteristic curve (AUC) greater than those found in serum for the nonspecific tumor markers carbohydrate antigen 19-9 (CA 19-9) and alpha-fetoprotein (AFP), commonly used to help in the diagnosis of iCCA and HCC, respectively. The development of an algorithm combining glycine, aspartic acid, SM(42:3), and SM(43:2) permitted to accurately differentiate in the diagnosis of both types of tumors (biopsy-proven). The proposed model yielded 0.890 AUC, 75% sensitivity, and 90% specificity. Another algorithm by combination of PC(34:3) and histidine accurately permitted to differentiate PSC from iCCA, with an AUC of 0.990, 100% sensitivity, and 70% specificity. These results were validated in independent cohorts of 14-15 patients per group and compared with profiles found in patients with nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. Conclusion: Specific changes in serum concentrations of certain metabolites are useful to differentiate iCCA from HCC or PSC, and could help in the early diagnosis of these diseases.

Published
2019

45. Serum Metabolites as Diagnostic Biomarkers for Cholangiocarcinoma, Hepatocellular Carcinoma, and Primary Sclerosing Cholangitis

Author

Banales, Jesus M., primary, Iñarrairaegui, Mercedes, additional, Arbelaiz, Ander, additional, Milkiewicz, Piotr, additional, Muntané, Jordi, additional, Muñoz‐Bellvis, Luis, additional, La Casta, Adelaida, additional, Gonzalez, Luis M., additional, Arretxe, Enara, additional, Alonso, Cristina, additional, Martínez‐Arranz, Ibon, additional, Lapitz, Ainhoa, additional, Santos‐Laso, Alvaro, additional, Avila, Matias A., additional, Martínez‐Chantar, Maria L., additional, Bujanda, Luis, additional, Marin, Jose J.G., additional, Sangro, Bruno, additional, and Macias, Rocio I.R., additional

Published
2019
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48. Association between gallbladder disease and pancreatic cancer risk according to tumour characteristics

Author

Molina-Montes, Esther, primary, Rosato, Valentina, additional, Gomez-Rubio, Paulina, additional, Löhr, Matthias, additional, Michalski, Cristoph W., additional, Molero, Xavier, additional, Marquez, Mirari, additional, Ilzarbe, Lucas, additional, Farre, Antonio, additional, Perea, Jose, additional, Greenhalf, William, additional, O’Rorke, Michael, additional, Tardón, Adonina, additional, Gress, Thomas, additional, Barbera, Victor M., additional, Crnogorac-Jurcevic, Tatjana, additional, Dominguez-Muñoz, Enrique, additional, Muñoz-Bellvis, Luis, additional, Sharp, Linda, additional, Scarpa, Aldo, additional, Hidalgo, Manuel, additional, Carrato, Alfredo, additional, Real, Francisco X., additional, and Malats, Núria, additional

Published
2017
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49. Recurrence of cystic echinococcosis in an endemic area: a retrospective study

Author

Velasco-Tirado, Virginia, primary, Romero-Alegría, Ángela, additional, Belhassen-García, Moncef, additional, Alonso-Sardón, Montserrat, additional, Esteban-Velasco, Carmen, additional, López-Bernús, Amparo, additional, Carpio-Perez, Adela, additional, Jimenez López, Marcelo Fernando, additional, Muñoz Bellido, Juan Luis, additional, Muro, Antonio, additional, Cordero-Sanchez, Miguel, additional, Pardo-Lledias, Javier, additional, and Muñoz-Bellvis, Luis, additional

Published
2017
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50. Pancreatic cancer risk in relation to lifetime smoking patterns, tobacco type, and dose-response relationships

Author

Montes, Esther Molina, van Hoogstraten, Lisa, Gómez-Rubio, Paulina, Löhr, J.-Matthias, Sharp, Linda, Molero, Xavier, Márquez, Mirari, Michalski, Christoph W., Farré, Antoni, Perea, José, O’Rorke, Michael, Greenhalf, William, Ilzarbe, Lucas, Tardón, Adonina, Gress, Thomas, Barberà, Victor, Crnogorac-Jurcevic, Tatjana, Muñoz-Bellvís, Luis, Dominguez-Muñoz, J Enrique, Balsells, Joaquim, Costello, Eithne, Iglesias, Mar, Kleeff, Jörg, Kong, Bo, Mora, Josefina, O’Driscoll, Damian, Poves, Ignasi, Scarpa, Aldo, Yu, Jingru, Ye, Weimin, Hidalgo, Manuel, Carrato, Alfredo, Lawlor, Rita, Real, Francisco X., and Malats, Núria

Published
2019
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