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12 results on '"Mumtaz, Amna"'

7. Bioinformatics analyses of microarray data reveal novel biomarker associated with cutaneous squamous cell carcinoma.

Author

Rashid, Ayesha, Rasool, Raza, Zaib, Muhammad Zeshan, Khan, Muhammad Hamza, Almutairi, Saeedah Musaed, Hussein, Dina S., Mumtaz, Amna, Abedien, Zain Ul, and Haq, Ihteshamul

Abstract

Global incidence of cutaneous squamous cell carcinoma is rising. This study investigated the molecular mechanism of CSCC and screened genes that could serve as biomarkers, providing a theoretical framework for pathogenesis and drug development research. We examined differentially expressed genes (DEGs) between normal tissue specimens and CSCC patient tissues using microarray data analysis.. Also, signal pathway and functional enrichment analysis were employed for target genes to rule out the specific genes that display close association with CSCC with the potential to serve as unique CSCC biomarkers. Two datasets GSE66359 and GSE45216 were used in the differential expression analysis. Results revealed the upregulation of potential candidate genes like P13, MMP1, A100A12, and KRT16 while downregulation of rf132, EGR3, PAMR1, LRP4, and KRT2. Verifying these genes demonstrated that KRT16 and EGR3 had obvious differential expression patterns. Further analyses showed that EGR3 was the only gene that exhibited a similar differential pattern in CSCC. Thus, we infer that EGR3 is closely related to the occurrence and development of CSCC, and it has the potential to function as the candidate biomarker gene against CSCC and facilitate subsequent diagnosis and treatment in clinical management. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Influence of Chitosan-Based Edible Coating on the Shelf Life and Nutritional Quality of Guava (Psidium guajava L.) Fruit in Room and Refrigerated Temperatures

Author

Shamshad, Areeqa, Iqbal, shahzad Zafar, Razis, Ahmad Faizal Abdull, Usman, Sunusi, Ali, Nada Basheir, Mumtaz, Amna, and Asi, Muhammad Rafique

Subjects
analytical_chemistry
Abstract

Guava is a vital fruit worldwide, especially in Pakistan, and due to its nutritional value famous in each age group. Due to a very short shelf life, the marketing and export of this fruit faced severe constraints. Therefore, in the current study, edible coating of chitosan (0, 0.5, 1.0, 1.5, and 2.0%) was evaluated on postharvest shelf life when guava fruits were stored (room temperature and 4 °C temperatures) for 12 days. The chitosan treated coating fruits have shown reduced total sugars and malondialdehyde levels compared to untreated control samples. However, a significant difference (p ≤ 0.05) in total sugar and malondialdehyde levels exists between samples stored in m compared to refrigerated temperature (4 °C). The chitosan-coated samples have shown a greater amount of vitamin C, quercetin, rutin, and total phenolic contents than control samples. However, these nutritional parameters' levels were significantly different (p ≤ 0.05) in samples stored at room than samples stored at refrigerated temperature. However, the levels of crude fiber, potassium, and sodium were found statistically nonsignificant (p ≥0.05) in control versus chitosan treated coating treatments. The findings have documented that the coatings of 1.5 and 2.0% were most effective for extension in shelf life and maintaining the nutritional attributes of guava fruit.

Published
2021

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