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3. Synthesis of <italic>N</italic>-Tosylates of 4-Methoxy-1,2,3,4-tetrahydrocarbazole and 2-(6-Methoxy-1-cycloalken-1-yl)anilines.

Author

Kirillova, I. А., Zalimova, М. M., Mulyukova, R. V., Vakhitova, Yu. V., Khusnitdinov, R. N., and Gataullin, R. R.

Subjects
METHOXY compounds, CARBAZOLE derivatives, REGIOSELECTIVITY (Chemistry), ANTINEOPLASTIC agents, CELL lines, PHYSIOLOGY
Abstract

The reaction of N-tosylates of 2-(1-cycloalken-1-yl)anilines and 2,3,9a,9-tetrahydro-1H-carbazole with methanol in the presence of CuBr2 proceeds with high regioselectivity leading to the corresponding tosylates of 2-(6-methoxy-1-cycloalken-1-yl)anilines and 4-methoxy-1,2,3,4-tetrahydrocarbazole. The latter as well as N-mesyl-1,2,3,4-tetrahydrocarbazole showed moderate cytotoxic activity with respect to HEK293 cell line. [ABSTRACT FROM AUTHOR]

Published
2018
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