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Your search keyword '"Mulvihill, Alan O."' showing total 18 results
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18 results on '"Mulvihill, Alan O."'

5. Retinal Haemorrhages in Childhood Encephalopathies: Review of a Prospective Research Programme.

Author

Minns, Robert A., Jones, Patricia A., Fleck, Brian W., and Mulvihill, Alan O.

Subjects
HEAD injury complications, INTENSIVE care units, STATISTICS, SCIENTIFIC observation, CHILD abuse, EYE hemorrhage, PATIENTS, CEREBRAL anoxia-ischemia, PEDIATRICS, MANN Whitney U Test, HOSPITAL admission & discharge, INTRACRANIAL pressure, DOCUMENTATION, T-test (Statistics), SYMPTOMS, KAPLAN-Meier estimator, DATA analysis software, DATA analysis, LOGISTIC regression analysis, LONGITUDINAL method, CHILDREN
Abstract

One important cause of retinal haemorrhages (RHs) in children is abusive head trauma (AHT). Our programme of research was conducted on children admitted to hospital over a seven‐year period who had RHs as part of their clinical presentation. This paper summarises important findings from previous publications. As a prerequisite, two basic studies were necessary: (i) a method of reporting the precise location of the RH in the retina; and (ii) defining a simple clinical classification of RHs based on the appearance of the retinal layer involved. Because raised intracranial pressure (RICP) is a frequent secondary brain insult following serious adult head injury, causing hypoxic‐ischaemic injury with a resultant poor outcome, it was considered whether such RICP might also cause RHs in children. Detailed, state‐of‐the‐art monitoring methods were used to investigate this relationship along with retinal imaging. Methodical documentation of the type, area and lifespan of RHs meant that it was possible to address the question of predicting AHT from RH numbers and characteristics, and to describe not only the duration of different layer haemorrhages, but also a previously unreported observation that some RHs transiently enlarge over two to three days before resolving normally. 'One important cause of retinal haemorrhages (RHs) in children is abusive head trauma' Key Practitioner Messages: A new retinal zone classification for research and legal purposes has been developed, as well as a simplified five‐point working classification of RHs, based on existing fundoscopic descriptions.In this cohort study, a young age and a high 'dot‐blot' count (>25 intraretinal haemorrhages) are strong predictors of AHT.There is a complex association between the burden of intracranial pressure insult and RHs.Time to resolution of different RHs has been calculated using two‐dimensional RH area pixel counts from sequential retinal imaging. Two patterns of resolution are reported. [ABSTRACT FROM AUTHOR]

Published
2022
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8. Detection and characterisation of visual field defects using Saccadic Vector Optokinetic Perimetry in children with brain tumours

Author

Murray, Ian C, Schmoll, Conrad, Perperidis, Antonios, Brash, Harry M, McTrusty, Alice D, Cameron, Lorraine A, Wilkinson, Alastair G, Mulvihill, Alan O, Fleck, Brian W, and Minns, Robert A

Subjects
Male, Adolescent, genetic structures, Brain Neoplasms, Vision Disorders, Sensitivity and Specificity, Article, Child, Preschool, Saccades, Journal Article, Humans, Visual Field Tests, Female, Visual Fields, Child
Abstract

PURPOSE: To determine the ability of Saccadic Vector Optokinetic Perimetry (SVOP) to detect and characterise visual field defects in children with brain tumours using eye-tracking technology, as current techniques for assessment of visual fields in young children can be subjective and lack useful detail.METHODS: Case-series study of children receiving treatment and follow-up for brain tumours at the Royal Hospital for Sick Children in Edinburgh from April 2008 to August 2013. Patients underwent SVOP testing and the results were compared with clinically expected visual field patterns determined by a consensus panel after review of clinical findings, neuroimaging, and where possible other forms of visual field assessment.RESULTS: Sixteen patients participated in this study (mean age of 7.2 years; range 2.9-15 years; 7 male, 9 female). Twelve children (75%) successfully performed SVOP testing. SVOP had a sensitivity of 100% and a specificity of 50% (positive predictive value of 80% and negative predictive value of 100%). In the true positive and true negative SVOP results, the characteristics of the SVOP plots showed agreement with the expected visual field. Six patients were able to perform both SVOP and Goldmann perimetry, these demonstrated similar visual fields in every case.CONCLUSION: SVOP is a highly sensitive test that may prove to be extremely useful for assessing the visual field in young children with brain tumours, as it is able to characterise the central 30° of visual field in greater detail than previously possible with older techniques.

Published
2018

18. Contributors

Author

Abu-Arafeh, Ishaq, Archer, N., Arkwright, Peter D., Auchterlonie, Ian A., Baker, Alastair J., Beath, Susan V., Beattie, Thomas F., Becher, Julie-Clare, Bisset, W. Michael, Blair, Peter S., Bolton-Maggs, Paula H.B., Brand, Paul L.P., Bruce, Colin E., Budge, Helen, Buist, Neil R.M., Burrows, Nigel Peter, Bush, Andrew, Butler, Gary, Cale, Catherine M., Campbell, Harry, Cant, Andrew J., Clarke, Michael, Cleary, Andrew Gavin, Coulter, J. Brian S., Coutts, Jonathan, Coward, Richard, Craig, Finella, David, Timothy J., Davidson, Joyce E., Davies, E. Graham, Dudley, Jan, Duell, P. Barton, Elphick, Heather, Embleton, Nicholas D., Enns, Gregory M., Farrar, Jeremy, Ferrie, Colin D., Fielder, Alistair R., Fleck, Brian W., Fleming, Peter J., Foster, Caroline, Freer, Yvonne, Ganesan, Vijeya, Garden, Anne S., Gennery, Andrew R., Gibb, Diana, Gibson, K. Michael, Golden, Barbara, Goldsmid, John M., Govan, John R.W., Graham, Stephen M., Green, Anne, Grompe, Marcus, Halliday, Henry L., Halsey, Christina, Harding, Cary O., Hart, C. Anthony, Heath, Paul T., Helms, Peter J., Henderson, John, Hilliard, Tom, Hoare, Peter, Howard, Richard F., Hughes, Imelda, Hume, Robert, Inward, Carol, Isaacs, David, Ismayl, Omar, Jenkins, Huw R., Jones, Cheryl A., Kelnar, Christopher J.H., Kemp, Alison M., Kerr, Alastair I.G., Kesson, Alison M., Kibel, Maurice A., Kitchiner, Denise, Klein, Nigel J., Koeller, David M., Kotecha, Sailesh, Kotloff, Karen, Laing, Ian A., Lalloo, David G., Leaf, Alison, Levene, Malcolm I., Linck, Leesa M., Livingston, John H., Logan, Stuart, Lockwood, Diana N.J., Lyon, Andrew J., Lyons, Ronan, Macdonald, Anita, McGraw, Mary, McHugh, Keiran, McIntosh, Neil, Mackinlay, G.A., McKinley, Ian, McLean, Sheila A.M., Maguire, Sabine, Main, Janice, Makin, Guy, Martland, Timothy, Mekasha, Amha, Mellis, Craig, Meyer, Stefan, Mills, Alan E., Molyneux, Elizabeth, Molyneux, Malcolm E., Mulholland, Kim, Mulvihill, Alan O., Newton, Richard W., Nicoll, Angus, Paton, James Y., Patton, Michael A., Pearl, Philip L., Pearson, Gale A., Petrou, Stavros, Ramage, Ian J., Reilly, John J., Rennie, J.M., Richmond, Sam, Roberts, Irene A.G., Rudd, Peter T., Robson, S.C., Roullet, Jean-Baptiste, Rylance, George, Saleem, Moin A., Salt, Alison, Sargent, Jenefer, Shafiq, Ayad, Skinner, Jonathan R., Smyth, Alan, Smyth, Rosalind L., Steiner, Robert D., Stenson, Ben, Stephenson, Terence, Stick, Stephen, Sturgiss, Stephen, Sweet, David, Thomas, Angela E., Tooley, James, Tizard, E. Jane, Viner, Russell, Webster, Rachel, Welsby, Philip D., Wildhaber, Johannes, Williams, Anthony F., Wills, Bridget A., Wilson, David C., Wood, Rachael, and Wren, Christopher

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