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10,390 results on '"Multiple sclerosis"'

1. Manifestations and impact of the COVID‐19 pandemic in neuroinflammatory diseases

Author

Seth N. Levin, Shruthi Venkatesh, Katie E. Nelson, Yi Li, Ines Aguerre, Wen Zhu, Karman Masown, Kathryn T. Rimmer, Claudiu I. Diaconu, Kaho B. Onomichi, Victoria M. Leavitt, Libby L. Levine, Rebecca Strauss‐Farber, Wendy S. Vargas, Brenda Banwell, Amit Bar‐Or, Joseph R. Berger, Andrew D. Goodman, Erin E. Longbrake, Jiwon Oh, Bianca Weinstock‐Guttman, Kiran T. Thakur, Keith R. Edwards, Claire S. Riley, Zongqi Xia, Philip L. De Jager, and Multiple Sclerosis Resilience to COVID‐19 (MSReCOV) Collaborative

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Objective To report initial results of a planned multicenter year‐long prospective study examining the risk and impact of COVID‐19 among persons with neuroinflammatory disorders (NID), particularly multiple sclerosis (MS). Methods In April 2020, we deployed online questionnaires to individuals in their home environment to assess the prevalence and potential risk factors of suspected COVID‐19 in persons with NID (PwNID) and change in their neurological care. Results Our cohort included 1115 participants (630 NID, 98% MS; 485 reference) as of 30 April 2020. 202 (18%) participants, residing in areas with high COVID‐19 case prevalence, met the April 2020 CDC symptom criteria for suspected COVID‐19, but only 4% of all participants received testing given testing shortages. Among all participants, those with suspected COVID‐19 were younger, more racially diverse, and reported more depression and liver disease. PwNID had the same rate of suspected COVID‐19 as the reference group. Early changes in disease management included telemedicine visits in 21% and treatment changes in 9% of PwNID. After adjusting for potential confounders, increasing neurological disability was associated with a greater likelihood of suspected COVID‐19 (ORadj = 1.45, 1.17–1.84). Interpretations Our study of real‐time, patient‐reported experience during the COVID‐19 pandemic complements physician‐reported MS case registries which capture an excess of severe cases. Overall, PwNID seem to have a risk of suspected COVID‐19 similar to the reference population.

Published
2021
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9. Effect of Workplace Violence on Turnover Intention: The Mediating Roles of Job Control, Psychological Demands, and Social Support

Author

Te-Feng Yeh PhD, Yu-Chia Chang PhD, Wei-Hsin Feng, Multiple sclerosis, and Cheng-Chia Yang PhD

Subjects
Public aspects of medicine, RA1-1270
Abstract

Exposing nursing staff to workplace violence workplace violence (WV) affects their psychological, emotional, and physical health; engenders increased workload; affects the medical reciprocity between nurses and patients; and ultimately leads to staff turnover intention. To preventing WV, development of intervention strategies and WV prevention measures are crucial. This study discusses the mediating effect of job control, psychological needs, and social support on WV and turnover intention. Through this discussion, this study aims to aid medical institutions in reducing their nursing staff turnover rate and to provide a reference for hospital management and decision making. A cross-sectional research method was adopted and conducted quantitative research to prove the complexity of the relationship between WV and turnover intention. Participants comprised clinical nurses working in 2 regional teaching hospital in central Taiwan. A total of 268 questionnaires were distributed, and 213 completed questionnaires were returned. Of the returned questionnaires, 198 contained valid responses, yielding a response rate of 73.9%. Our results demonstrated the mechanisms through which psychological demands and social support mediate the relationship between WV and turnover intention. This study determined the mediating effects of psychological demands and social support. The results expand the findings of previous research and demonstrate the complexity of the relationship between WV and turnover intention. Hospitals should formulate effective mechanisms for preventing and addressing incidents of WV, improve their ability to address and regulate violent incidents in clinics, reduce the psychological pressure exerted on employees, and establish communication channels for social support.

Published
2020
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19. Comparative Effectiveness Study Telerehab Versus Conventional

Author

University of Alabama at Birmingham, University of North Carolina, Chapel Hill, University of Georgia, The Cleveland Clinic, University of Colorado, Denver, Marquette University, Accelerated Cure Project for Multiple Sclerosis, Patient-Centered Outcomes Research Institute, Tanner Foundation for Multiple Sclerosis, Massachusetts General Hospital, and Deborah Backus, Director of Multiple Sclerosis Research

Published
2023

27. Swiss Multiple Sclerosis Cohort-Study (SMSC)

Author

Cantonal Hospital of Aarau, Switzerland, Cantonal Hospital of St. Gallen, Insel Gruppe AG, University Hospital Bern, Regional Hospital Lugano (EOC), Switzerland, University Hospital, Geneva, University of Lausanne Hospitals, and National Multiple Sclerosis Society

Published
2024

34. Blood neurofilament light chain measurements in adults with CNS histiocytic neoplasms

Author

Samantha A. Banks, Paul Decker, Eoin P. Flanagan, Anastasia Zekeridou, Ronald S. Go, Jithma P. Abeykoon, Gaurav Goyal, Jason R. Young, Matthew J. Koster, Robert Vassallo, Jay H. Ryu, Caroline J. Davidge-Pitts, Aishwarya Ravindran, Julio C. Sartori Valinotti, N. Nora Bennani, Mithun V. Shah, Karen L. Rech, Corrie R. Bach, Jeanette E. Eckel-Passow, W. Oliver Tobin, and the Mayo Clinic-University of Alabama at Birmingham Histiocytosis Working Group and Center for Multiple Sclerosis and Autoimmune Neurology at Mayo Clinic

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published
2024
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42. PARE: A framework for removal of confounding effects from any distance-based dimension reduction method.

Author

Andrew A Chen, Kelly Clark, Blake E Dewey, Anna DuVal, Nicole Pellegrini, Govind Nair, Youmna Jalkh, Samar Khalil, Jon Zurawski, Peter A Calabresi, Daniel S Reich, Rohit Bakshi, Haochang Shou, Russell T Shinohara, and Alzheimer’s Disease Neuroimaging Initiative, and North American Imaging in Multiple Sclerosis Cooperative

Subjects
Biology (General), QH301-705.5
Abstract

Dimension reduction tools preserving similarity and graph structure such as t-SNE and UMAP can capture complex biological patterns in high-dimensional data. However, these tools typically are not designed to separate effects of interest from unwanted effects due to confounders. We introduce the partial embedding (PARE) framework, which enables removal of confounders from any distance-based dimension reduction method. We then develop partial t-SNE and partial UMAP and apply these methods to genomic and neuroimaging data. For lower-dimensional visualization, our results show that the PARE framework can remove batch effects in single-cell sequencing data as well as separate clinical and technical variability in neuroimaging measures. We demonstrate that the PARE framework extends dimension reduction methods to highlight biological patterns of interest while effectively removing confounding effects.

Published
2024
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48. Minocycline in MS: Confirmation of Benefit (MS)

Author

Hotchkiss Brain Institute, University of Calgary, Multiple Sclerosis Society of Canada, and Dr. Luanne Metz, Professor, Department of Clinical Neurosciences, University of Calgary

Published
2023

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