193 results on '"Multiple risk factor"'
Search Results
2. Lipid testing and prediction of coronary heart disease
- Author
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Carlson, Lars A. and Carlson, Lars A.
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- 2011
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3. Extraction of Risk Factors by Multi-agent Voting Model Using Automatically Defined Groups
- Author
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Hara, Akira, Ichimura, Takumi, Takahama, Tetsuyuki, Isomichi, Yoshinori, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, Khosla, Rajiv, editor, Howlett, Robert J., editor, and Jain, Lakhmi C., editor
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- 2005
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4. Maximizing Cancer Risk Reduction Efforts: Addressing Multiple Risk Factors Simultaneously
- Author
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Emmons, Karen M., Park, Elyse, Colditz, Graham A., editor, and Hunter, David, editor
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- 2000
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5. Racial aspects of elder abuse
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George, James and Eastman, Mervyn, editor
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- 1994
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- View/download PDF
6. Multiple Risk Factors in an Italian Population in the 1980s: The Gubbio Study
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Laurenzi, M., Stamler, R., Mancini, M., Cirillo, M., Trevisan, M., Farinaro, E., Menotti, A., Stamler, J., Gotto, Antonio M., Jr., editor, Lenfant, Claude, editor, Paoletti, Rodolfo, editor, and Soma, Maurizio, editor
- Published
- 1992
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- View/download PDF
7. Cardiovascular Risk Factors and Intervention in Children
- Author
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Berenson, G. S., Srinivasan, S. R., Webber, L. S., Gotto, Antonio M., Jr., editor, Lenfant, Claude, editor, Paoletti, Rodolfo, editor, and Soma, Maurizio, editor
- Published
- 1992
- Full Text
- View/download PDF
8. The Lipid Hypothesis: Is it the Only Cause of Atherosclerosis?
- Author
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Castelli, William P., Gotto, Antonio M., Jr., editor, Lenfant, Claude, editor, Paoletti, Rodolfo, editor, and Soma, Maurizio, editor
- Published
- 1992
- Full Text
- View/download PDF
9. Mild COVID-19 manifestation in multiple risk factor patient on methotrexate, who had been treated with UVB phototherapy and had sufficient plasma 25-OH-vitamin D3 level
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Hrvoje Jakovac and Martina Kralj
- Subjects
Vitamin ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Clinical course ,medicine.disease ,Gastroenterology ,vitamin D deficiency ,UVB phototherapy ,Multiple risk factor ,chemistry.chemical_compound ,chemistry ,Internal medicine ,medicine ,Methotrexate ,business ,medicine.drug - Abstract
We report mild COVID-19 manifestation in high-risk patient with sufficient plasma 25-OH-Vitamin D3 level. Given the global pandemic of vitamin D deficiency, as well as its likely beneficial effects during SARS-CoV-2 infection, report highlights importance of routine 25-OH-Vitamin D3 measurement, either for clinical course prediction or deciding on supplementation.
- Published
- 2021
10. What are the effects of multiple risk factor interventions for primary prevention of coronary heart disease (CHD)?
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Jane Burch and Sera Tort
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Multiple risk factor ,medicine.medical_specialty ,business.industry ,Primary prevention ,Psychological intervention ,Medicine ,General Medicine ,business ,Intensive care medicine ,Coronary heart disease - Published
- 2020
11. Patterns and Average Volume of Alcohol Use Among Women of Childbearing Age.
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Tsai, James, Floyd, R. Louise, Green, Patricia P., and Boyle, Coleen A.
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MATERNAL health , *ALCOHOL drinking , *HUMAN abnormalities , *NEUROBEHAVIORAL disorders , *BINGE drinking , *WOMEN'S tobacco use , *PREGNANT women - Abstract
Objectives: Maternal alcohol use is a leading preventable cause of neurobehavioral and developmental abnormalities in children. This study examines the patterns and average volume of alcohol use among U.S. women of childbearing age in order to identify subgroups of high-risk women for selective intervention. Methods: A sample of 188,290 women aged 18–44 years participated in the Centers for Disease Controls and Prevention (CDC)’s Behavioral Risk Factor Surveillance System (BRFSS) survey during the period of 2001–2003. Reported alcohol use patterns and average volume were examined for pregnant and nonpregnant women. Efforts were made to evaluate and characterize women who practiced various levels of binge drinking. Results: The results showed that approximately 2% of pregnant women and 13% of nonpregnant women in the United States engaged in binge drinking during the period of 2001–2003. Among the estimated average of 6.7 million women of childbearing age overall who engaged in binge drinking during the period, approximately 28.5% women also reported consuming an average of 5 drinks or more on typical drinking days, or about 21.4% women consumed at least 45 drinks on average in a month. Larger proportions of binge drinkers with high usual quantity of consumption were found among women of younger ages (18–24 years) or current smokers. Conclusions: Future prevention efforts should include strategies that combine health messages and encourage women of childbearing age, with particular emphasis on women 18–24 years, to avoid alcohol and tobacco use, and take multivitamins and folic acid daily for better pregnancy outcomes. Other efforts must also include broad-based implementation of screening and brief intervention for alcohol misuse in primary and women’s health care settings. [ABSTRACT FROM AUTHOR]
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- 2007
- Full Text
- View/download PDF
12. A win ratio approach to the re-analysis of Multiple Risk Factor Intervention Trial
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Anne Eaton, Ales Kotalik, James D. Neaton, Qinshu Lian, Carlos Serrano, and John E. Connett
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Adult ,Male ,medicine.medical_specialty ,Endpoint Determination ,01 natural sciences ,Outcome (game theory) ,Multiple risk factor ,010104 statistics & probability ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Outcome Assessment, Health Care ,medicine ,Humans ,030212 general & internal medicine ,Intervention trial ,0101 mathematics ,Intensive care medicine ,Proportional Hazards Models ,Randomized Controlled Trials as Topic ,Pharmacology ,business.industry ,Clinical events ,Composite outcomes ,General Medicine ,Middle Aged ,Clinical trial ,Cardiovascular Diseases ,business - Abstract
Background: Composite outcomes, which combine multiple types of clinical events into a single outcome, are common in clinical trials. The usual analysis considers the time to first occurrence of any event in the composite. The major criticisms of such an approach are (1) this implicitly treats the outcomes as if they were of equal importance, but they often vary in terms of clinical relevance and severity, (2) study participants often experience more than one type of event, and (3) often less severe events occur before more severe ones, but the usual analysis disregards any information beyond that first event. Methods: A novel approach, referred to as the win ratio, which addresses the aforementioned criticisms of composite outcomes, is illustrated with a re-analysis of data on fatal and non-fatal cardiovascular disease time-to-event outcomes reported for the Multiple Risk Factor Intervention Trial. In this trial, 12,866 participants were randomized to a special intervention group ( n = 6428) or a usual care ( n = 6438) group. Non-fatal outcomes were ranked by risk of cardiovascular disease death up to 20 years after trial. In one approach, participants in the special intervention and usual care groups were first matched on coronary heart disease risk at baseline and time of enrollment. Each matched pair was categorized as a winner or loser depending on which one experienced a cardiovascular disease death first. If neither died of cardiovascular disease causes, they were evaluated on the most severe non-fatal outcome. This process continued for all the non-fatal outcomes. A second win ratio statistic, obtained from Cox partial likelihood, was also estimated. This statistic provides a valid estimate of the win ratio using multiple events if the marginal and conditional survivor functions of each outcome satisfy proportional hazards. Loss ratio statistics (inverse of win ratios) are compared to hazard ratios from the usual first event analysis. A larger 11-event composite was also considered. Results: For the 7-event cardiovascular disease composite, the previously reported first event analysis based on 581 events in the special intervention group and 652 events in the usual care group yielded a hazard ratio (95% confidence interval) of 0.89 (0.79–0.99), compared to 0.86 (0.77–0.97) and 0.91 (0.81–1.02) for the severity ranked estimates. Results for the 11-event composite also confirmed the findings of the first event analysis. Conclusion: The win ratio analysis was able to leverage information collected past the first experienced event and rank events by severity. The results were similar to and confirmed previously reported traditional first event analysis. The win ratio statistic is a useful adjunct to the traditional first event analysis for trials with composite outcomes.
- Published
- 2019
13. The Importance and Role of Multiple Risk Factor Control in Type 2 Diabetes
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Mitra Mosslemi, Christian Torp-Pedersen, Christina Ji-Young Lee, Caroline Holm Nørgaard, and Nathan D. Wong
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Population ,Health Behavior ,Type 2 diabetes ,030204 cardiovascular system & hematology ,Multiple risk factor ,03 medical and health sciences ,0302 clinical medicine ,Swedish population ,Risk Factors ,Environmental health ,Diabetes mellitus ,medicine ,Humans ,In patient ,030212 general & internal medicine ,Healthy Lifestyle ,Risk factor ,education ,education.field_of_study ,business.industry ,medicine.disease ,Cardiovascular disease ,Diabetes Mellitus, Type 2 ,Cardiovascular Diseases ,Risk factor control ,Observational study ,Cardiology and Cardiovascular Medicine ,business - Abstract
PURPOSE OF REVIEW: The importance of composite risk factor control for reducing CVD risk in type 2 diabetes (T2DM) has gained increased attention and here we review the latest findings in the field.RECENT FINDINGS: The Steno-2 study was the first to show that early intensive risk factor control could improve risk factor status and halve the CVD risk in patients with diabetes with lasting impact. A range of observational studies have added further insight to the importance of multiple risk factor control showing an incremental association between number of risk factors controlled and reduction in CVD risk. Noteworthy, a Swedish population-based study recently showed that optimal risk factor status in patients with T2DM was associated with a CVD risk similar to the general population. Early intensive intervention to achieve optimal risk factor control reduces CVD risk and should be of principal focus in T2DM management.
- Published
- 2019
14. Attributable fraction for multiple risk factors: Methods, interpretations, and examples
- Author
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Matteo Di Maso, Carlo La Vecchia, Monica Ferraroni, Diego Serraino, Francesca Bravi, Eva Negri, Adriano Decarli, Jerry Polesel, Di Maso, Matteo, Bravi, Francesca, Polesel, Jerry, Negri, Eva, Decarli, Adriano, Serraino, Diego, La Vecchia, Carlo, and Ferraroni, Monica
- Subjects
Statistics and Probability ,Epidemiology ,Population ,adjusted method ,Multiple risk factors ,Risk Assessment ,01 natural sciences ,partitioning methods ,010104 statistics & probability ,03 medical and health sciences ,0302 clinical medicine ,Health Information Management ,Risk Factors ,Environmental health ,Prevalence ,Medicine ,030212 general & internal medicine ,0101 mathematics ,Risk factor ,education ,Disease burden ,education.field_of_study ,business.industry ,Smoking ,Case-control study ,multiple risk factor ,case–control study ,Attributable fraction ,Case-Control Studies ,Attributable risk ,business - Abstract
The attributable fraction is the candidate tool to quantify individual shares of each risk factor on the disease burden in a population, expressing the proportion of cases ascribable to the risk factors. The original formula ignored the presence of other factors (i.e. multiple risk factors and/or confounders), and several adjusting methods for potential confounders have been proposed. However, crude and adjusted attributable fractions do not sum up to their joint attributable fraction (i.e. the number of cases attributable to all risk factors together) and their sum may exceed one. A different approach consists of partitioning the joint attributable fraction into exposure-specific shares leading to sequential and average attributable fractions. We provide an example using Italian case–control data on oral cavity cancer comparing crude, adjusted, sequential, and average attributable fractions for smoking and alcohol and provide an overview of the available software routines for their estimation. For each method, we give interpretation and discuss shortcomings. Crude and adjusted attributable fractions added up over than one, whereas sequential and average methods added up to the joint attributable fraction = 0.8112 (average attributable fractions for smoking and alcohol were 0.4894 and 0.3218, respectively). The attributable fraction is a well-known epidemiological measure that translates risk factors prevalence and disease occurrence in useful figures for a public health perspective. This work endorses their proper use and interpretation.
- Published
- 2019
15. Kinder mit multipler Risikoexposition profitieren von der Teilnahme an 'Familien stärken!'
- Author
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Monika Thomsen, Peter-Michael Sack, Sonja Bröning, and Rainer Thomasius
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Gynecology ,050103 clinical psychology ,medicine.medical_specialty ,Early adolescence ,05 social sciences ,language.human_language ,German ,Multiple risk factor ,03 medical and health sciences ,0302 clinical medicine ,Political science ,language ,medicine ,0501 psychology and cognitive sciences ,030212 general & internal medicine ,Substance use ,Differential impact - Abstract
Zusammenfassung Untersucht wurde die deutsche Adaptation des aus Iowa stammenden suchtpraventiven, familienbasierten Strengthening Families Program 10-14 (SFP) in einer Langsschnittstudie mit 2-Jahres-Katamnese. Studienteilnehmer waren N = 292 zu t0 im Mittel zwolf Jahre alten Kinder und N = 292 Eltern. Das Studiendesign war multizentrisch, randomisiert-kontrolliert und zweiarmig (SFP vs. Minimalintervention). Wir vermuten hier gemas der „risk moderation hypothesis“, dass Kinder mit erhohter Risikoexposition R(+) unabhangig von der Interventionsform mehr profitieren als Kinder mit geringer Risikoexposition R(−), und dass R(+) speziell unter SFP mehr profitieren als unter der Minimalintervention. „Risikoexposition“ wurde vor allem gemas des Fragebogens zum Communities That Care Youth Survey bestimmt, danach waren 28 % der Kinder multipel bzw. hoch risikoexponiert. Die Elternberichte bestatigen zwar unsere Hypothesen, die Selbstberichte der Kinder fallen noch deutlicher aus: R(+) berichten insgesamt von elf...
- Published
- 2016
16. Clustering of Lifestyle Risk Factors in Acute Coronary Syndrome: Prevalence and Change after the First Event
- Abstract
Background: Healthy lifestyles are modifiable risk factors for acute coronary syndrome (ACS) onset and recurrence. While unhealthy lifestyles tend to cluster together within the general healthy population, little is known about the prevalence and clustering of these behaviours in people with ACS before and after the first acute event. The aim of this study was to identify lifestyle profiles of patients with ACS and to explore their change after their first coronary event. Methods: Three hundred and fifty-six patients completed self-report measures of healthy habits at the beginning of cardiac rehabilitation and 6 months later. By adopting a person-oriented approach, we analysed lifestyle clustering and its change over time. Differences in depression, anxiety, and negative illness perception among lifestyle profiles were assessed. Results: We identified seven profiles, ranging from more maladaptive to healthier clusters. Findings showed a strong interrelation among unhealthy habits in patients. We highlighted a moderate individual and group stability of cluster membership over time. Moreover, unhealthier lifestyle profiles were associated with higher levels of depression, anxiety, and negative illness perception. Conclusion: These results may have implications for the development and implementation of multimodal interventions addressing wider-ranging improvement in lifestyles by targeting multiple unhealthy behaviours in patients with ACS.
- Published
- 2018
17. Borrowing of strength and study weights in multivariate and network meta-analysis
- Author
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Ian R. White, Malcolm J Price, John B. Copas, Dan Jackson, and Richard D Riley
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Statistics and Probability ,Multivariate statistics ,Epidemiology ,Computer science ,Network Meta-Analysis ,Myocardial Infarction ,Score ,Blood Pressure ,Biostatistics ,01 natural sciences ,Article ,Correlation ,Multiple risk factor ,010104 statistics & probability ,03 medical and health sciences ,0302 clinical medicine ,Health Information Management ,Statistics ,Humans ,Thrombolytic Therapy ,030212 general & internal medicine ,0101 mathematics ,Randomized Controlled Trials as Topic ,Likelihood Functions ,Models, Statistical ,Descriptive statistics ,Univariate ,social sciences ,Random effects model ,Stroke ,Cardiovascular Diseases ,Meta-analysis ,Hypertension ,Multivariate Analysis - Abstract
Multivariate and network meta-analysis have the potential for the estimated mean of one effect to borrow strength from the data on other effects of interest. The extent of this borrowing of strength is usually assessed informally. We present new mathematical definitions of ‘borrowing of strength’. Our main proposal is based on a decomposition of the score statistic, which we show can be interpreted as comparing the precision of estimates from the multivariate and univariate models. Our definition of borrowing of strength therefore emulates the usual informal assessment. We also derive a method for calculating study weights, which we embed into the same framework as our borrowing of strength statistics, so that percentage study weights can accompany the results from multivariate and network meta-analyses as they do in conventional univariate meta-analyses. Our proposals are illustrated using three meta-analyses involving correlated effects for multiple outcomes, multiple risk factor associations and multiple treatments (network meta-analysis).
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- 2015
18. Normalisation theory: Does it accurately describe temporal changes in adolescent drunkenness and smoking?
- Author
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Sharon R. Sznitman, Yossi Harel-Fisch, and Cheryl Zlotnick
- Subjects
education.field_of_study ,030505 public health ,Health (social science) ,Population level ,Population ,Health behaviour ,030508 substance abuse ,Medicine (miscellaneous) ,Multiple risk factors ,Logistic regression ,Multiple risk factor ,03 medical and health sciences ,Risk model ,Risk factor ,0305 other medical science ,Psychology ,education ,Social psychology ,Demography - Abstract
Introduction and Aims The multiple risk model postulates that accumulating risk factors increase adolescent drunkenness and smoking. The normalisation theory adds to this by arguing that the relation between accumulative risk and drunkenness and smoking is dependent on the distribution of these behaviours in the larger population. More concretely, normalisation theory predicts that: (i) when population level use increases, low risk adolescents will be more likely to use alcohol and cigarettes; and (ii) adolescents facing multiple risk factors will be equally likely to use alcohol and cigarettes, regardless of trends in population level use. The current study empirically tests these assumptions on five waves of nationally representative samples of Israeli Jewish youth. Design and Methods Five cross-sectional waves of data from the Israeli Health Behaviour in School-aged Children survey for Jewish 10th graders were used. Logistic regression models measured the impact of changes in population level use across waves on drunkenness and smoking, and their association with differing levels of risk factors. Results Between zero and two risk factors, the risk of drunkenness and smoking increases for each additional risk factor. When reaching two risk factors, added risk does not significantly increase the likelihood of smoking and drunkenness. Changes in population level drunkenness and smoking did not systematically relate to changes in the individual level relationship between risk factors and smoking and drunkenness. Discussion and Conclusions The pattern of results in this study provides strong evidence for the multiple risk factor model and inconsistent evidence for the normalisation theory. [Sznitman SR, Zlotnick C, Harel-Fisch Y. Normalisation theory: Does it accurately describe temporal changes in adolescent drunkenness and smoking? Drug Alcohol Rev 2015]
- Published
- 2015
19. The Impact of Health on Labor Market Outcomes: Experimental Evidence from MRFIT
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Desmond Toohey and Melvin Stephens
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Earnings ,business.industry ,Family income ,Coronary heart disease ,law.invention ,Multiple risk factor ,Randomized controlled trial ,law ,Intervention (counseling) ,Medicine ,Intervention trial ,business ,Baseline (configuration management) ,Demography - Abstract
While economists have posited that health investments increase earnings, isolating the causal effect of health is challenging due both to reverse causality and unobserved heterogeneity. We examine the labor market effects of a randomized controlled trial, the Multiple Risk Factor Intervention Trial (MRFIT), which monitored nearly 13,000 men for over six years. We find that this intervention, which provided a bundle of treatments to reduce coronary heart disease mortality, increased earnings and family income. We find few differences in estimated gains by baseline health and occupation characteristics. Reductions in serious illnesses and work-limiting disabilities likely contributed to the observed gains.
- Published
- 2018
20. Clustering of Lifestyle Risk Factors in Acute Coronary Syndrome: Prevalence and Change after the First Event
- Author
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Francesco Fattirolli, Marco D’Addario, Andrea Greco, Patrizia Steca, Dario Monzani, Cristina Giannattasio, Francesco Quarenghi, Monzani, D, D'Addario, M, Fattirolli, F, Giannattasio, C, Greco, A, Quarenghi, F, Steca, P, Monzani D., D'Addario M., Fattirolli F., Giannattasio C., Greco A., Quarenghi F., and Steca P.
- Subjects
Adult ,Male ,Settore M-PSI/01 - Psicologia Generale ,Change over time ,Gerontology ,Acute coronary syndrome ,medicine.medical_treatment ,Psychological intervention ,acute coronary syndrome ,behavioural change ,healthy lifestyle ,multiple risk factors ,typological approach ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Prevalence ,medicine ,Humans ,Longitudinal Studies ,030212 general & internal medicine ,Cluster analysis ,Group stability ,Life Style ,Applied Psychology ,Depression (differential diagnoses) ,Aged ,Cardiac Rehabilitation ,030505 public health ,Rehabilitation ,multiple risk factor ,Middle Aged ,medicine.disease ,Cross-Sectional Studies ,Anxiety ,Female ,medicine.symptom ,0305 other medical science ,Psychology - Abstract
Background: Healthy lifestyles are modifiable risk factors for acute coronary syndrome (ACS) onset and recurrence. While unhealthy lifestyles tend to cluster together within the general healthy population, little is known about the prevalence and clustering of these behaviours in people with ACS before and after the first acute event. The aim of this study was to identify lifestyle profiles of patients with ACS and to explore their change after their first coronary event. Methods: Three hundred and fifty-six patients completed self-report measures of healthy habits at the beginning of cardiac rehabilitation and 6months later. By adopting a person-oriented approach, we analysed lifestyle clustering and its change over time. Differences in depression, anxiety, and negative illness perception among lifestyle profiles were assessed. Results: We identified seven profiles, ranging from more maladaptive to healthier clusters. Findings showed a strong interrelation among unhealthy habits in patients. We highlighted a moderate individual and group stability of cluster membership over time. Moreover, unhealthier lifestyle profiles were associated with higher levels of depression, anxiety, and negative illness perception. Conclusion: These results may have implications for the development and implementation of multimodal interventions addressing wider-ranging improvement in lifestyles by targeting multiple unhealthy behaviours in patients with ACS.
- Published
- 2018
21. Simplifying the medical prevention of cardiovascular disease
- Author
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David S. Wald
- Subjects
Multiple risk factor ,Estimation ,Potential impact ,medicine.medical_specialty ,Drug treatment ,business.industry ,medicine ,Alternative medicine ,General Medicine ,Disease ,Intensive care medicine ,business ,Surgery - Abstract
There is enormous potential to reduce deaths and disability from cardiovascular disease by widening the use and simplifying access to blood pressure and cholesterol-lowering preventive treatment. The main obstacles to realizing this potential are the complexity of multiple risk factor-based risk estimation, an excessively high risk cut-off for treatment and a focus on testing rather than prevention. A fresh approach to prevention is needed that replaces complex multiple risk factor-based assessments with a simple age cut-off as the means of selecting people for preventive drug treatment. This review examines the evidence for such an approach and its potential impact.
- Published
- 2014
22. METABOLIC SYNDROME: CHALLENGING AND UNRESOLVED ISSUES
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G. A. A. Chumakova, N. G. Veselovskaya, O. V. Gritsenko, and A. V. Ott
- Subjects
Pathology ,medicine.medical_specialty ,risk factor cluster ,business.industry ,visceral obesity ,Bioinformatics ,medicine.disease ,Polycystic ovary ,metabolic syndrome ,Multiple risk factor ,RC666-701 ,Diseases of the circulatory (Cardiovascular) system ,Medicine ,Metabolic syndrome ,Cardiology and Cardiovascular Medicine ,business ,Visceral Obesity - Abstract
The paper focuses on the contradictory issues related to metabolic syndrome (MS), its criteria, and real-world prognostic value. Different types of obesity, which result from a variety of combinations of general and visceral obesity, are described. The authors emphasise the need for two separate definitions of MS (a wider one and a more specific one), which are characterised by different pathogenetic mechanisms and require different therapeutic approaches. The more specific MS definition could benefit from the inclusion of such criteria as fatty liver and polycystic ovary syndrome. More detailed definitions for the multiple risk factor cluster syndrome, as an alternative to the current MS definition, are proposed for further discussion.
- Published
- 2014
23. Multiple risk factor dependence structures: Copulas and related properties
- Author
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Jianxi Su and Edward Furman
- Subjects
Statistics and Probability ,Domain of a function ,Economics and Econometrics ,Computer science ,020209 energy ,media_common.quotation_subject ,02 engineering and technology ,01 natural sciences ,Asymmetry ,Domain (mathematical analysis) ,Copula (probability theory) ,FOS: Economics and business ,Multiple risk factor ,010104 statistics & probability ,0502 economics and business ,0202 electrical engineering, electronic engineering, information engineering ,Econometrics ,Default risk ,0101 mathematics ,Factor analysis ,media_common ,Mathematics ,050208 finance ,05 social sciences ,Tail dependence ,Enterprise risk management ,Risk Management (q-fin.RM) ,Variety (universal algebra) ,Statistics, Probability and Uncertainty ,Quantitative Finance - Risk Management - Abstract
Copulas have become an important tool in the modern best practice Enterprise Risk Management, often supplanting other approaches to modelling stochastic dependence. However, choosing the ‘right’ copula is not an easy task, and the temptation to prefer a tractable rather than a meaningful candidate from the encompassing copulas toolbox is strong. The ubiquitous applications of the Gaussian copula are just one illuminating example. Speaking generally, a ‘good’ copula should conform to the problem at hand, allow for asymmetry in the domain of definition and exhibit some extent of tail dependence. In this paper we introduce and study a new class of Multiple Risk Factor (MRF) copula functions, which we show are exactly such. Namely, the MRF copulas (1) arise from a number of meaningful default risk specifications with stochastic default barriers, (2) are in general non-exchangeable and (3) possess a variety of tail dependences. That being said, the MRF copulas turn out to be surprisingly tractable analytically.
- Published
- 2016
24. Is Risk Factor Intervention Worthwhile?
- Author
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Simons, Leon A., Gibson, Joyce Corey, Simons, Leon A., and Gibson, Joyce Corey
- Published
- 1980
- Full Text
- View/download PDF
25. Do multiple risk factor interventions help to prevent cardiovascular disease in low- and middle-income countries?
- Author
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Bipin Thapa
- Subjects
Multiple risk factor ,business.industry ,Low and middle income countries ,Environmental health ,Psychological intervention ,Medicine ,General Medicine ,Disease ,business - Published
- 2016
26. Measurement of Blood Pressure in the Office
- Author
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Sheldon W. Tobe, Marshall Godwin, Martin Dawes, Janusz Kaczorowski, Alexander Kiss, and Martin G. Myers
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Male ,medicine.medical_specialty ,Pediatrics ,Ambulatory blood pressure ,Office Visits ,Population ,MEDLINE ,Diastolic Hypertension ,Multiple risk factor ,Risk Factors ,Internal Medicine ,medicine ,Humans ,education ,Ontario ,education.field_of_study ,Framingham Risk Score ,business.industry ,White coat ,Reproducibility of Results ,Blood Pressure Determination ,Blood Pressure Monitoring, Ambulatory ,Reference Standards ,Blood Pressure Monitors ,Self Care ,Blood pressure ,Hypertension ,Emergency medicine ,Female ,business - Abstract
The widely accepted cut-point for normal blood pressure (BP) in the office setting evolved over several decades, based on data derived from a variety of sources. The Actuarial Society of America was one of the first organizations to publish BP data on thousands of community residents, followed by other classic studies such as Framingham, Western Electric Company, Kaiser Permanente, and the Multiple Risk Factor Intervention Trial.1,2 In every instance, BP readings were based on measurements taken by specially trained health professionals following guidelines for proper BP measurement. As a result of these and other population studies examining the association between different BP levels and cardiovascular outcomes, the importance of systolic and diastolic hypertension was recognized and an office BP of 140/90 mm Hg became the universally established cut-point for separating normal BP from hypertension. There are robust scientific data to support the use of 140/90 mm Hg to define hypertension in clinical practice guidelines. However, the guidelines do not take into account widely recognized problems associated with the quality of manual BP measurement in routine clinical practice.3 More recent recommendations4 for diagnosing hypertension clearly acknowledge that an increase in BP attributable to the “white coat response” is frequently associated with manual BP recordings performed in community-based practice. In recognizing this limitation of manual office BP, some guidelines have gone so far as to recommend that home BP and 24-hour ambulatory BP monitoring (ABPM) may need to be performed to obtain an accurate measure of a patient’s BP status. The greater reliance on 24-hour ABPM and home BP in the diagnosis and management of hypertension is the result of numerous clinical outcome studies5,6 that show that these measurement techniques are better predictors of cardiovascular events when compared to manual BP readings, even when manual readings are taken …
- Published
- 2010
27. Association Between Heart Rate and Multiple Risk Factor Syndrome Cross-Sectional Analysis of a Screened Cohort in Okinawa, Japan
- Author
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Chiho Iseki, Shuichi Takishita, Kunitoshi Iseki, Taku Inoue, Yusuke Ohya, and Kozen Kinjo
- Subjects
medicine.medical_specialty ,Pediatrics ,business.industry ,Cross-sectional study ,General Medicine ,medicine.disease ,Multiple risk factor ,Quartile ,Health evaluation ,Internal medicine ,Epidemiology ,Cohort ,Heart rate ,medicine ,Metabolic syndrome ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Increased heart rate (HR) and metabolic syndrome are risk factors for cardiovascular morbidity and mortality, but their relationship has not been studied in a large, screened cohort. Methods and Results The association between HR and multiple risk factor syndrome, resembling metabolic syndrome, was examined in participants of a health evaluation program in 1997. Of the 8,432 subjects (5,223 males, 3,209 females, 18‐89 years of age), 1,502 (1,185 males, 317 females) were diagnosed with multiple risk factor syndrome and these subjects had higher HR than those without the syndrome (p
- Published
- 2008
28. Social Desirability Trait Influences on Self-Reported Dietary Measures among Diverse Participants in a Multicenter Multiple Risk Factor Trial
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Linda Nebeling, James R. Hébert, Karen E. Peterson, Margaret Ehlers, Ken Resnicow, Frances E. Thompson, Geoffrey C. Williams, Amy L. Yaroch, Geoffrey W. Greene, Doug Midthune, and Thomas G. Hurley
- Subjects
Adult ,Male ,Randomization ,Adolescent ,Medicine (miscellaneous) ,Health outcomes ,Dietary fruit ,law.invention ,Multiple risk factor ,Social desirability bias ,Bias ,Social Desirability ,Randomized controlled trial ,Risk Factors ,law ,Vegetables ,Humans ,Medicine ,Social desirability ,Nutrition and Dietetics ,business.industry ,Feeding Behavior ,Middle Aged ,Dietary Fats ,Diet ,Fruit ,Mental Recall ,Trait ,Female ,Energy Intake ,business ,Demography - Abstract
Data collected at 4 Behavioral Change Consortium sites were used to assess social desirability bias in self-reports derived from a dietary fat screener (PFat), a dietary fruit and vegetable screener (FVS), and a 1-item question on fruit and vegetable intake. Comparisons were made with mean intakes derived from up to 3 24-h recall interviews at baseline and follow-up (at 12 mo in 3 sites, 6 mo in the fourth). A social-desirability-related underestimate in fat intake on the PFat relative to the 24HR (percentage energy as fat) was evident in women [baseline b = -0.56 (P = 0.005); follow-up b = -0.62 (P < 0.001)]. There was an overestimate in FVS-derived fruit and vegetable consumption (servings/week) in men enrolled in any intervention at follow-up (b = 0.39, P = 0.05) vs. baseline (b = 0.04, P = 0.75). The 1-item fruit and vegetable question was associated with an overestimate at baseline in men according to SD score (b = 0.14, P = 0.02), especially men with less than college education (b = 0.23, P = 0.01). Women with less than college education expressed a similar bias at follow-up (b = 0.13, P = 0.02). Differences in the magnitude of bias according to gender, type of instrument used, and randomization condition are comparable to what has been seen for other instruments and have important implications for both measuring change in studies of diet and health outcomes and for developing methods to control for such biases.
- Published
- 2008
29. ???Beyond blood pressure??? means multiple risk factor intervention, not pleiotropic antihypertensive drugs
- Author
-
Yan Li, Tatiana Kuznetsova, Lutgarde Thijs, Willem H. Birkenhäger, Tom Richart, Jan A. Staessen, and Ji-Guang Wang
- Subjects
Drug ,medicine.medical_specialty ,media_common.quotation_subject ,Angiotensin-Converting Enzyme Inhibitors ,Blood Pressure ,Pharmacology ,Diabetes Complications ,Multiple risk factor ,Risk Factors ,Intervention (counseling) ,Diabetes mellitus ,Internal medicine ,Humans ,Medicine ,Diuretics ,Adverse effect ,Antihypertensive Agents ,Randomized Controlled Trials as Topic ,media_common ,business.industry ,Absolute risk reduction ,Calcium Channel Blockers ,medicine.disease ,Blood pressure ,Increased risk ,Cardiovascular Diseases ,Hypertension ,Cardiology and Cardiovascular Medicine ,business - Abstract
PURPOSE OF REVIEW We examined the role of blood pressure-lowering compared with class-specific properties of antihypertensive drugs in cardiovascular prevention. RECENT FINDINGS We reviewed recently published trials and meta-regression analyses. SUMMARY From 150,000 to 180,000 randomized patients followed up from 3 to 5 years were required to demonstrate a 10-15% benefit 'beyond blood pressure lowering' of newer antihypertensive drugs, such as calcium channel blockers or angiotensin-converting enzyme inhibitors in the prevention of cause-specific cardiovascular complications. Assuming an absolute risk of new-onset diabetes mellitus on older drugs of approximately 10% over 5 years and a relative benefit on the newer drugs of approximately 30%, about 100 patients would have to be treated for 5 years with the newer agents to avert approximately three iatrogenic cases of diabetes. Whether or not new-onset diabetes is associated with increased risk is uncertain. In most patients, optimization of treatment at acceptable tolerance requires rotation through and combination of several drug classes. Combination of different classes of antihypertensive drugs not only enhances the blood pressure-lowering efficacy, but likely decreases the risk of metabolic adverse effects as well. True benefit beyond blood pressure lowering in hypertensive patients comes from multiple risk factor intervention.
- Published
- 2007
30. A Clinical Case of Chronic Periodontitis with the Multiple Risk Factor Syndrome
- Author
-
Hideo Arai, Fusanori Nishimura, Yoshihiro Iwamoto, Masayuki Shimoe, and Shogo Takashiba
- Subjects
Multiple risk factor ,medicine.medical_specialty ,business.industry ,Internal medicine ,Medicine ,Clinical case ,business ,medicine.disease ,Chronic periodontitis - Published
- 2007
31. Dietary Polyunsaturated Fatty Acids and Mortality in the Multiple Risk Factor Intervention Trial (MRFIT)
- Author
-
G Granditis and T A Dolecek
- Subjects
chemistry.chemical_classification ,medicine.medical_specialty ,business.industry ,Proportional hazards model ,MEDLINE ,law.invention ,Multiple risk factor ,Clinical trial ,Multicenter study ,chemistry ,Randomized controlled trial ,law ,Internal medicine ,Medicine ,Intervention trial ,business ,Polyunsaturated fatty acid - Published
- 2015
32. Multiple-stage screening and mortality in the Multiple Risk Factor Intervention Trial
- Author
-
Yu Dai, Avis J. Thomas, James D. Neaton, and Lynn E. Eberly
- Subjects
Adult ,Male ,Multiple stages ,medicine.medical_specialty ,Coronary Disease ,01 natural sciences ,Multiple risk factor ,010104 statistics & probability ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Healthy volunteers ,medicine ,Humans ,Mass Screening ,030212 general & internal medicine ,Intervention trial ,0101 mathematics ,Proportional Hazards Models ,Randomized Controlled Trials as Topic ,Pharmacology ,business.industry ,Patient Selection ,Medical screening ,General Medicine ,Middle Aged ,medicine.disease ,United States ,Survival Rate ,Design phase ,Clinical trial ,Sample size determination ,Emergency medicine ,Medical emergency ,business ,Follow-Up Studies - Abstract
Background During the design phase of a clinical trial, sample size estimates should take into account medical screening criteria, the ‘healthy volunteer’ effect, consequences of run-in phases, and secular trends in the event rate of interest. All of these have been shown to relate to subsequent event rates, and hence trial power to detect intervention effects. The Multiple Risk Factor Intervention Trial (MRFIT) used three successive screenings of 361 662 men to enroll 12 866; observed coronary heart disease (CHD) mortality after a mean of 6.9 years was substantially lower than projected during design. We explore factors which may have contributed to these mortality differences and whether they persisted throughout follow-up. Methods Proportional hazards models were used to compare 25-year mortality according to trial eligibility, self-exclusions, medical exclusions, and participation. Results After adjustment for baseline risk factors and age, there was higher mortality among men excluded for presence of disease [hazard ratio (HR) 1.52, 95% confidence interval (CI) 1.43–1.61, for total; HR 1.92, CI 1.75–2.11, for CHD] compared to those not excluded which persisted throughout follow-up. Volunteers had lower total (HR 0.82, CI 0.76–0.87) and CHD (HR 0.79, CI 0.70–0.88) mortality than those discontinuing participation. Men excluded with characteristics deemed likely to interfere with adherence had higher total (HR 1.19, CI 1.07–1.33) and noncardiovascular disease (CVD) (HR 1.32, CI 1.14–1.53) mortality but no higher CVD (HR 1.04, CI 0.88–1.23) or CHD (HR 0.98, CI 0.80–1.20) mortality compared to those not excluded. Differences in mortality were stronger during the first five years, but declined only slightly over 25 years. Conclusions 25-year mortality was significantly higher for non-volunteers and exclusions. Differences between observed and predicted six-year total mortality for trial participants were largely attributable to volunteers and exclusions, but there were additional differences for CHD mortality, which were likely due to downward secular trends. These results emphasize the importance of anticipating these factors during clinical trial design, even for trials of short duration.
- Published
- 2004
33. Pulmonary function as a predictor of lung cancer mortality in continuing cigarette smokers and in quitters
- Author
-
Lewis H. Kuller, Lingfeng Yang, Lynn E. Eberly, Judith K. Ockene, and Roger Sherwin
- Subjects
Adult ,Counseling ,Male ,medicine.medical_specialty ,Lung Neoplasms ,Epidemiology ,Risk Assessment ,Smoking history ,Pulmonary function testing ,Multiple risk factor ,Forced Expiratory Volume ,Internal medicine ,medicine ,Humans ,Intervention trial ,Lung cancer ,Lung ,Proportional Hazards Models ,Analysis of Variance ,business.industry ,Proportional hazards model ,Smoking ,Hazard ratio ,General Medicine ,Middle Aged ,respiratory system ,medicine.disease ,respiratory tract diseases ,Surgery ,Cholesterol ,Hypertension ,Smoking Cessation ,Risk assessment ,business ,Follow-Up Studies - Abstract
Background Forced expiratory volume in 1 second (FEV 1 ) may be useful for identifying smokers at higher risk of lung cancer. We examined the association of FEV 1 with lung cancer mortality (LCM) among cigarette smokers in the Multiple Risk Factor Intervention Trial (MRFIT). Methods In all, 6613 MRFIT baseline smokers alive at trial end in 1982 had acceptable FEV 1 measures and complete smoking history; men were classified as during-trial long-term quitters (N = 1292), intermittent quitters (1961), and never quitters (3360). Proportional hazards models for LCM were fit with quintiles of average FEV 1 , adjusted for age, height, race, smoking history, and other risk factors. Results For long-term, intermittent, and never quitters respectively, mean baseline cigarettes/ day was 28, 32, and 35; trial-averaged FEV 1 was 3201, 3146, and 3082 ml; and average decline in FEV 1 was ‐46.0, ‐54.6, and ‐62.5 ml/year. With median posttrial mortality follow-up of 18 years, there were 363 lung cancer deaths. Ageadjusted LCM rates varied across FEV 1 quintiles from 50 (lowest quintile) to 11 (highest quintile), 58 to 11, and 76 to 20, per 10 000 person-years, for long-term quitters, intermittent quitters, and never quitters, respectively. Multivariate adjusted hazard ratios for 100 ml higher FEV 1 were 0.92 [P = 0.004], 0.95 [P = 0.003], and 0.95 [P � 0.0001] respectively. Conclusions These results demonstrate the strong predictive value of FEV 1 for lung cancer among cigarette smokers independent of smoking history; results did not differ by during-trial quit status. FEV 1 may be a biological marker for smoking dose or it may be that genetic susceptibilities to both decreased FEV 1 and lung cancer are associated.
- Published
- 2003
34. Multiple risk factor interventions and inflammatory biomarkers in high risk individuals with type 2 diabetes
- Author
-
John Chalmers, Eugene Sobngwi, and Andre Pascal Kengne
- Subjects
Inflammation ,Gerontology ,Oncology ,medicine.medical_specialty ,business.industry ,Endocrinology, Diabetes and Metabolism ,Psychological intervention ,General Medicine ,Type 2 diabetes ,medicine.disease ,Inflammatory biomarkers ,Multiple risk factor ,C-Reactive Protein ,Endocrinology ,Diabetes Mellitus, Type 2 ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,business ,Biomarkers - Published
- 2012
35. Long-Term Effects of Chlorthalidone Versus Hydrochlorothiazide on Electrocardiographic Left Ventricular Hypertrophy in the Multiple Risk Factor Intervention Trial
- Author
-
W.J. Elliott
- Subjects
medicine.medical_specialty ,business.industry ,Left ventricular hypertrophy ,medicine.disease ,Term (time) ,Multiple risk factor ,Hydrochlorothiazide ,Internal medicine ,Cardiology ,Medicine ,Chlorthalidone ,Intervention trial ,business ,medicine.drug - Published
- 2012
36. Clinical implication of multiple risk factor control in the management of diabetic macrovasucular complications
- Author
-
Y Kimura, Masaaki Suzuki, O Murase, M Takeuchi, Hideki Ito, Y Yamazaki, Y Hattori, Hajime Orimo, H Inada, Hajime Nawata, and Yutaka Harano
- Subjects
Blood Glucose ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Blood Pressure ,Type 2 diabetes ,Body Mass Index ,Multiple risk factor ,Endocrinology ,Japan ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,Humans ,Medicine ,Prospective cohort study ,business.industry ,Incidence ,Incidence (epidemiology) ,medicine.disease ,Surgery ,Cross-Sectional Studies ,Diabetes Mellitus, Type 2 ,Cutoff point ,business ,Diabetic Angiopathies - Abstract
Using cross-sectional and prospective analyses, the risk factors for macroangiopathy (MA) in nonobese Type 2 diabetic patients were evaluated. In the cross-sectional study, we determined a cutoff point for each variable at which changes in the prevalence of total MA reached statistically significant levels. In the prospective study, those who met more than four out of seven control criteria as set forth in the Multiclinical Study for Diabetic Macroangiopathy (MSDM) had less risk of MA in Type 2 diabetes initially diagnosed without MA compared with those who fulfilled less than three factors. These results suggest that multiple risk factor control is the most effective and reasonable way to lower the incidence of MA in Type 2 diabetes.
- Published
- 2002
37. Insulin Sensitizers and Atherosclerosis
- Author
-
Shigeru Yatoh and Nobuhiro Yamada
- Subjects
Arteriosclerosis ,business.industry ,Insulin ,medicine.medical_treatment ,Biochemistry (medical) ,Receptors, Cytoplasmic and Nuclear ,medicine.disease ,Bioinformatics ,Clinical trial ,Multiple risk factor ,Thiazoles ,Insulin resistance ,Diabetes mellitus ,Glucose Intolerance ,Hyperlipidemia ,Internal Medicine ,medicine ,Animals ,Humans ,Insulin Resistance ,Cardiology and Cardiovascular Medicine ,business ,Clinical treatment ,Transcription Factors - Abstract
It is surprising that only about ten years after the concept of insulin resistance in diabetes mellitus was established, the role of insulin resistance in the development of atherosclerosis has been discussed and clarified. Insulin resistance predisposes the development of glucose intolerance, hyperlipidemia, and hypertension; the cluster of these abnormalities is referred to as multiple risk factor syndrome and it increases the risk of atherosclerosis. A few insulin sensitizers have recently begun to be used in the therapy for diabetic patients. However, the inhibitory effects of these insulin sensitizers against atherosclerosis have not been studied in large-scale clinical trials because these drugs were approved for clinical treatment only several years ago. Accordingly, this review presents a summary of the previous studies on the anti-atherogenic effects of insulin sensitizers by different strategies and provides information on why it is expected that insulin sensitizers will be used as anti-atherogenic drugs.
- Published
- 2002
38. Multiple Risk Factor Intervention Trial
- Author
-
Jeremiah Stamler, Lynn E. Eberly, Lewis H. Kuller, and James D. Neaton
- Subjects
Multiple risk factor ,medicine.medical_specialty ,business.industry ,Physical therapy ,Medicine ,Intervention trial ,business ,Trial Screening - Published
- 2014
39. Elevated Serum Leptin Concentrations in Women with Components of Multiple Risk Factor Clustering Syndrome
- Author
-
Shoji Maruoka, Shinji Katayose, Miyao Matsubara, and Hitoshi Chiba
- Subjects
Adult ,Leptin ,medicine.medical_specialty ,Adolescent ,Arteriosclerosis ,Diastole ,Blood lipids ,Blood Pressure ,Hyperlipidemias ,Body Mass Index ,Elevated serum ,Multiple risk factor ,Insulin resistance ,Japan ,Risk Factors ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Obesity ,Triglycerides ,Aged ,Aged, 80 and over ,business.industry ,Biochemistry (medical) ,Syndrome ,Middle Aged ,medicine.disease ,Pathophysiology ,Cholesterol ,Cross-Sectional Studies ,Blood pressure ,Endocrinology ,Hypertension ,Female ,Insulin Resistance ,Cardiology and Cardiovascular Medicine ,business - Abstract
This cross sectional study was undertaken to determine whether serum leptin levels were associated with multiple risk factor (MRF) clustering syndrome. We examined the relationship between serum leptin concentrations and blood pressure (BP), serum lipids levels, calculated insulin resistance (HOMA-ratio) and adiposity among 581 Japanese adult women. The serum leptin was increased in female subjects with systolic (or =160 mmHg) and diastolicor =90 mmHg) hypertension compared with the normotensive females (mean+/-SE; 9.3+/-0.5 vs 7.7+/-0.3; 10.2+/-0.6 vs 7.1+/-0.3 ng/ml, both p0.001). Serum leptin was elevated in those with hyper-cholesterolemia (C;or =220 mg/dl) and triglyceridemia (TG;or =150 mg/dl) compared with the normolipidemia (9.4+/-0.4 vs 7.8+/-0.3; 11.7+/-0.6 vs 7.5+/-0.2 ng/ml, both p0.001). Serum leptin was also elevated in those with adiposity (BMIor =26.4 kg/m2) and insulin resistance (HOMA-ratioor =2.5) compared with the normal females (14.8+/-0.7 vs 5.2+/-0.2; 11.3+/-1.1 vs 7.1+/-0.4ng/ml, both p0.001). Even after adjusting for BMI or percent body fat mass (BFM), leptin levels remained to be elevated significantly in all these diseases. There was a positive correlation between serum leptin and systolic, diastolic BP, TC, TG, BMI, BFM, IRI and HOMA-ratio (r=0.12, p=0.005; r=0.24, p0.0001; r=0.19, p0.0001; r=0.35, p0.0001; r=0.72, p0.0001; r=0.73, p0.0001; r=0.47, p0.0001; r=0.44, p0.0001), and a negative correlation with HDL-C levels (r= -0.20, p0.0001). These correlations were also observed in leptin levels after adjusting for the BMI or BFM. Multiple regression analysis showed that BFM, HOMA-ratio and TG were significant determinants of leptin concentration before (t=12.6, p0.0001; t=3.33, p=0.001; t=3.22, p=0.001) and after adjusting for BMI or BFM. These results suggest that because serum leptin levels were elevated in components of MRF clustering syndrome, leptin may have a pathophysiological role in MRF clustering syndrome.
- Published
- 2000
40. Assessment of cardiovascular risk by use of multiple-risk-factor assessment equations
- Author
-
Sidney C. Smith, Philip Greenland, Scott M. Grundy, Richard C. Pasternak, and Valentin Fuster
- Subjects
Multiple risk factor ,medicine.medical_specialty ,Health professionals ,business.industry ,Statement (logic) ,Family medicine ,MEDLINE ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,Association (psychology) - Published
- 1999
41. Does Multiple Risk Factor Reduction Explain the Reduction in Fall Rate in the Yale FICSIT Trial?
- Author
-
Elizabeth B. Claus, Gail McAvay, and Mary E. Tinetti
- Subjects
Gerontology ,Activities of daily living ,Epidemiology ,business.industry ,law.invention ,Multiple risk factor ,Randomized controlled trial ,law ,Medicine ,Risk factor ,business ,Falling (sensation) ,Range of motion ,Balance (ability) ,Demography ,Fall prevention - Abstract
In a recent study of fall prevention in 301 community-living older persons (the Yale FICSIT Trial, 1990-1993), participants in the multifactorial targeted intervention (TI) group experienced significantly fewer falls than participants in the social visit (SV) control group. In the present paper, the authors explore the relation between changes in the studied risk factors and the occurrence of falling. In comparison with SV participants, TI participants showed significantly greater improvements in postural blood pressure change (p = 0.01), step length (p = 0.004), use of > or = 4 medications (p = 0.003), and unsafe tub and toilet transfers (p = 0.05), while change in balance was of borderline significance (p = 0.08). Reduction in the occurrence of falling, in turn, was at least marginally associated with improvements in balance, postural blood pressure change, step length, lower extremity strength/range of motion, and transfers. When participants were divided into tertiles based on a composite risk factor change score, a significantly higher percentage of TI participants (42%) than SV participants (22%) were in the greatest risk factor reduction tertile. Among TI participants, there was a progressively lower fall rate per person per year in the tertiles with the least, intermediate, and greatest risk reduction (0.832, 0.624, and 0.260), respectively. A similar but weaker relation between risk factor reduction and fall rate was seen in the SV group. When compared within tertiles, essentially adjusting for the amount of risk factor reduction, the fall rates among TI and SV participants in the greatest risk factor reduction tertile were identical (0.260 falls per person per year), and the rates in the least reduction tertile were similar (0.832 vs. 1.040 falls per person per year); this suggests that risk factor reduction at least partially mediated the treatment effect. These results support the feasibility of implementing and analyzing the effectiveness of a multiple risk factor reduction strategy in the aged.
- Published
- 1996
42. Leveraging Technology for Multiple Risk Factor Interventions
- Author
-
William T. Riley
- Subjects
Gerontology ,Multiple risk factor ,business.industry ,Behavior change ,Internal Medicine ,Psychological intervention ,Medicine ,business - Published
- 2012
43. Coexistence of visceral fat and multiple risk factor accumulations is strongly associated with coronary artery disease in Japanese (the VACATION-J study)
- Author
-
Aki Hiuge-Shimizu, Yoichi Nozaki, Iichiro Shimomura, Masaaki Okutsu, Hiroshi Kobayashi, Tohru Yoshizumi, Tohru Funahashi, Akihiro Nomura, Hiroyoshi Yokoi, Satoru Sumitsuji, Ryosuke Kametani, Tetsuya Ohira, Ken Kishida, Yuji Matsuzawa, and Tadashi Nakamura
- Subjects
Male ,medicine.medical_specialty ,Coronary Artery Disease ,Intra-Abdominal Fat ,Coronary Angiography ,Gastroenterology ,Body Mass Index ,Multiple risk factor ,Coronary artery disease ,Insulin resistance ,Asian People ,Risk Factors ,Internal medicine ,Glucose Intolerance ,Internal Medicine ,Medicine ,Humans ,Risk factor ,Aged ,business.industry ,Biochemistry (medical) ,Odds ratio ,medicine.disease ,Confidence interval ,Endocrinology ,Hypertension ,Female ,Insulin Resistance ,Cardiology and Cardiovascular Medicine ,business ,Tomography, X-Ray Computed ,Body mass index ,Dyslipidemia - Abstract
Aim: Multiple risk factor syndrome is a target for the prevention of coronary artery disease (CAD). A cluster of multiple risk factors, such as hypertension, glucose intolerance, and/or dyslipidemia, is encountered in Japanese without and with excess visceral fat. The present study investigated the relationship between multiple risk factor accumulation and CAD in Japanese without and with visceral fat accumulation. Methods: The study subjects comprised 257 Japanese with suspected CAD (males/females =153/ 104), who underwent 64-row multislice computed tomography (CT) coronary angiography and visceral fat area (VFA) measurement by CT. Based on the Japanese criteria for visceral fat accumulation, they were divided into those with VFA <100 and ≥ 100 cm 2 . Results: In subjects with VFA <100 cm 2 , the age- and sex-adjusted odds ratios (ORs) for 2 and 3 risk factors were 5.33 (95% confidence intervals; 1.04-27.38, p=0.0449) and 4.07 (0.72-23.15, p=0.1138), respectively, compared with VFA <100 cm 2 and 0 risk factor set at 1.0 (p=0.0569 for trend). In contrast, the respective ORs for subjects with VFA ≥ 100 cm 2 were much higher [6.46 (1.25-33.44, p=0.0261) and 20.42 (3.60-115.73, p=0.0007)] (p<0.0001 for trend). The multivariate adjusted model demonstrated a significant relative excess CAD risk of 1.08 (p=0.0484) and 5.01 (p<0.0001) for the interactions of 2 risk factors and VFA ≥ 100 cm 2 , and 3 risk factors and VFA ≥ 100 cm 2 , whereas multiple risk factor accumulation was not related with the increase of CAD risk in subjects with VFA <100 cm 2 . Conclusions: Coexistence of visceral fat and risk factor accumulations is strongly associated with CAD in Japanese. J Atheroscler Thromb, 2012; 19:000-000.
- Published
- 2012
44. Patient-Level Evaluation of Community-Based, Multifactorial Intervention to Prevent Diabetic Nephropathy in Northern Alberta, Canada
- Author
-
Holly Hoang, John-Michael Gamble, Dean T. Eurich, Peter A. Senior, and Kailash Jindal
- Subjects
Community and Home Care ,Community based ,medicine.medical_specialty ,business.industry ,lcsh:Public aspects of medicine ,Public Health, Environmental and Occupational Health ,Psychological intervention ,Alberta canada ,lcsh:RA1-1270 ,Type 2 diabetes ,medicine.disease ,lcsh:Computer applications to medicine. Medical informatics ,Multifactorial intervention ,Nephropathy ,Multiple risk factor ,Diabetic nephropathy ,Physical therapy ,Medicine ,lcsh:R858-859.7 ,business ,Intensive care medicine - Abstract
Objective: To examine whether patients with type 2 diabetes enrolled in community-based clinics uniformly benefit from interventions designed to achieve multiple risk factor targets. Methods: Using data from community-based clinics in Alberta, Canada, we examined whether patients achieved targets for blood pressure (
- Published
- 2012
45. A pilot study evaluating multiple risk factor interventions by community pharmacists to prevent cardiovascular disease: the PAART CVD pilot project
- Author
-
Johnson George, James Dunbar, Gregory M. Peterson, Shane L Jackson, Edward D Janus, Stephen Bunker, Gregory Duncan, Michael Bailey, Kevin McNamara, H Howarth, and Sharleen O'Reilly
- Subjects
Program evaluation ,Male ,medicine.medical_specialty ,education ,Health Behavior ,Psychological intervention ,MEDLINE ,Pharmacy ,Pilot Projects ,Disease ,Pharmacists ,Multiple risk factor ,Risk Factors ,Intervention (counseling) ,Health care ,medicine ,Humans ,Pharmacology (medical) ,Aged ,Pharmacies ,business.industry ,Professional-Patient Relations ,Middle Aged ,Primary Prevention ,Cardiovascular Diseases ,Family medicine ,Physical therapy ,Female ,business ,Program Evaluation - Abstract
There is insufficient evidence for the efficacy of comprehensive multiple risk factor interventions by pharmacists in the primary prevention of cardiovascular disease (CVD). Given the proven benefits of pharmacist interventions for individual risk factors, it is essential that evidence for a comprehensive approach to care be generated so that pharmacists remain key members of the health care team for individuals at risk of initial onset of CVD.To establish the feasibility of an intervention delivered by community pharmacists to reduce the risk of primary onset of CVD.A single-cohort intervention study was undertaken in 2008-2009. Twelve community pharmacists from 10 pharmacies who were trained to provide lifestyle and medicine management support to reduce CVD risk recruited 70 at-risk participants aged 50-74 years who were free from diabetes or CVD. Participants received a baseline assessment to establish CVD risk and health behaviors. An assessment report provided to patients and pharmacists was used to collaboratively establish treatment goals and, over 5 sessions, implement treatment strategies. Follow-up assessment at 6 months measured changes in baseline parameters. The primary outcome was the average change to overall 5-year risk of CVD onset.Sixty-seven participants were included in the analysis. The mean participant age was 60 years and 73% were female. We observed a 25% (95% CI 17 to 33) proportional risk reduction in overall CVD risk. Significant reductions also occurred in mean blood pressure (-11/-5 mm Hg) and waist circumference (-1.3 cm), with trends toward improvement for most other observed risk factors.Findings support previous evidence of positive cardiovascular health outcomes following pharmacist intervention in other patient groups; we recommend generating randomized controlled trial evidence for a primary prevention population.
- Published
- 2012
46. Propensity Score Matching
- Author
-
Ton J. Cleophas and Aeilko H. Zwinderman
- Subjects
Multiple risk factor ,Randomized controlled trial ,law ,Computer science ,Propensity score matching ,Covariate ,Statistics ,Confounding ,Observational study ,Regression analysis ,Regression ,law.invention - Abstract
Propensity-scores and propensity-score-matching can be used respectively for adjusting covariates in a multiple regression analysis and for stratification/matching of asymmetric observational clinical data, and have recently been emphasized by Dr. D’Agostino in an invited paper in Circulation as a promising additional tool for analyzing such data (D’Agostino 2007). It was first described by Rosenbaum and Rubin in 1985 (Rosenbaum and Rubin 1985), as a method for adjusting confounding variables, otherwise called covariates, alternative to the usual subclassification and regression methods. In the pas few years its application has been extended to so-called propensity-score-matching, a method able to transform asymmetric into symmetric data that can be further analyzed like randomized controlled trials. Due to the increase of costs for randomized trials, more and more clinical investigators turn to observational studies as a method of research. The current chapter was written to familiarize the readership of this book with these relatively novel methods.
- Published
- 2011
47. Outcomes from a Multiple Risk Factor Diabetes Self-Management Trial for Latinas: ¡Viva Bien!
- Author
-
Diane K. King, Lisa A. Strycker, Manuel Barrera, Diego Osuna, Russell E. Glasgow, and Deborah J. Toobert
- Subjects
Gerontology ,Adult ,Health Behavior ,Psychological intervention ,MEDLINE ,Diabetes self management ,Article ,law.invention ,Medication Adherence ,Multiple risk factor ,Quality of life (healthcare) ,Randomized controlled trial ,Nursing ,law ,Risk Factors ,Medicine ,Humans ,skin and connective tissue diseases ,General Psychology ,Aged ,Self-management ,business.industry ,Hispanic or Latino ,Middle Aged ,Patient Acceptance of Health Care ,humanities ,Self Care ,Psychiatry and Mental health ,Health psychology ,Outcome and Process Assessment, Health Care ,Diabetes Mellitus, Type 2 ,Quality of Life ,Female ,sense organs ,business ,human activities - Abstract
Culturally appropriate interventions are needed to assist Latinas in making multiple healthful lifestyle changes.The purpose of this study was to test a cultural adaptation of a successful multiple health behavior change program, ¡Viva Bien!Random assignment of 280 Latinas with type 2 diabetes to usual care only or to usual care + ¡Viva Bien!, which included group meetings for building skills to promote the Mediterranean diet, physical activity, stress management, supportive resources, and smoking cessation.¡Viva Bien! participants compared to usual care significantly improved psychosocial and behavioral outcomes (fat intake, stress management practice, physical activity, and social-environmental support) at 6 months, and some improvements were maintained at 12 months. Biological improvements included hemoglobin A1c and heart disease risk factors.The ¡Viva Bien! multiple lifestyle behavior program was effective in improving psychosocial, behavioral, and biological/quality of life outcomes related to heart health for Latinas with type 2 diabetes.
- Published
- 2011
48. Multiple risk factor interventions for primary prevention of coronary heart disease
- Author
-
Andrew D Beswick, Shah Ebrahim, Fiona Taylor, Kirsten J. Ward, Margaret Burke, and George Davey Smith
- Subjects
medicine.medical_specialty ,Framingham Risk Score ,Heart disease ,business.industry ,MEDLINE ,Psychological intervention ,medicine.disease ,Coronary heart disease ,Multiple risk factor ,Meta-analysis ,medicine ,Physical therapy ,Pharmacology (medical) ,Risk factor ,Intensive care medicine ,business - Abstract
BACKGROUND: Multiple risk factor interventions using counselling and educational methods assumed to be efficacious and cost-effective in reducing coronary heart disease (CHD) mortality and morbidity and that they should be expanded. Trials examining risk factor changes have cast doubt on the effectiveness of these interventions. OBJECTIVES: To assess the effects of multiple risk factor interventions for reducing total mortality, fatal and non-fatal events from CHD and cardiovascular risk factors among adults assumed to be without prior clinical evidence CHD.. SEARCH STRATEGY: We updated the original search BY SEARCHING CENTRAL (2006, Issue 2), MEDLINE (2000 to June 2006) and EMBASE (1998 to June 2006), and checking bibliographies. SELECTION CRITERIA: Randomised controlled trials of more than six months duration using counselling or education to modify more than one cardiovascular risk factor in adults from general populations, occupational groups or specific risk factors (i.e. diabetes, hypertension, hyperlipidaemia, obesity). DATA COLLECTION AND ANALYSIS: Two authors extracted data independently. We expressed categorical variables as odds ratios (OR) with 95% confidence intervals (CI). Where studies published subsequent follow-up data on mortality and event rates, we updated these data. MAIN RESULTS: We found 55 trials (163,471 participants) with a median duration of 12 month follow up. Fourteen trials (139,256 participants) with reported clinical event endpoints, the pooled ORs for total and CHD mortality were 1.00 (95% CI 0.96 to 1.05) and 0.99 (95% CI 0.92 to 1.07), respectively. Total mortality and combined fatal and non-fatal cardiovascular events showed benefits from intervention when confined to trials involving people with hypertension (16 trials) and diabetes (5 trials): OR 0.78 (95% CI 0.68 to 0.89) and OR 0.71 (95% CI 0.61 to 0.83), respectively. Net changes (weighted mean differences) in systolic and diastolic blood pressure (53 trials) and blood cholesterol (50 trials) were -2.71 mmHg (95% CI -3.49 to -1.93), -2.13 mmHg (95% CI -2.67 to -1.58 ) and -0.24 mmol/l (95% CI -0.32 to -0.16), respectively. The OR for reduction in smoking prevalence (20 trials) was 0.87 (95% CI 0.75 to 1.00). Marked heterogeneity (I(2) > 85%) for all risk factor analyses was not explained by co-morbidities, allocation concealment, use of antihypertensive or cholesterol-lowering drugs, or by age of trial. AUTHORS' CONCLUSIONS: Interventions using counselling and education aimed at behaviour change do not reduce total or CHD mortality or clinical events in general populations but may be effective in reducing mortality in high-risk hypertensive and diabetic populations. Risk factor declines were modest but owing to marked unexplained heterogeneity between trials, the pooled estimates are of dubious validity. Evidence suggests that health promotion interventions have limited use in general populations.
- Published
- 2011
49. Analysis of the etiology in 458 pancreatitis patients according to the M-ANNHEIM multiple risk factor classification
- Author
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Manfred V. Singer, J. M. Löhr, and Alexander Schneider
- Subjects
Multiple risk factor ,medicine.medical_specialty ,business.industry ,Internal medicine ,Gastroenterology ,medicine ,Etiology ,Pancreatitis ,medicine.disease ,business - Published
- 2010
50. ¡Viva Bien!: Overcoming Recruitment Challenges in a Multiple-Risk-Factor Diabetes Trial
- Author
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Alyssa Tinley Doty, Cristy R. Geno, Manuel Barrera, Lisa A. Strycker, Diego Osuna, Debra P. Ritzwoller, Russell E. Glasgow, and Deborah J. Toobert
- Subjects
Gerontology ,Adult ,medicine.medical_specialty ,Health (social science) ,Social Psychology ,Health Personnel ,Alternative medicine ,MEDLINE ,Ethnic group ,Article ,law.invention ,Multiple risk factor ,Randomized controlled trial ,law ,Pregnancy ,Risk Factors ,Diabetes mellitus ,Surveys and Questionnaires ,Health care ,medicine ,Humans ,Randomized Controlled Trials as Topic ,business.industry ,Patient Selection ,Public Health, Environmental and Occupational Health ,Hispanic or Latino ,medicine.disease ,humanities ,United States ,Telephone ,Clinical trial ,Outcome and Process Assessment, Health Care ,Diabetes Mellitus, Type 2 ,Socioeconomic Factors ,Female ,business - Abstract
Objectives To describe recruitment of Latinas in a randomized clinical trial conducted within 2 health care organizations. Methods The study relied on project-initiated telephone calls as part of a multifaceted recruitment approach. Chi-square and t tests were conducted to compare participants and nonparticipants on a number of variables. Results From 4045 telephone contacts, 280 Latinas agreed to participate. Most were ineligible due to non-Latino ethnicity (89%). Of eligible candidates, 61% took part. Few significant differences were found on participant vs nonparticipant characteristics. Conclusions Using appropriate recruitment procedures, a representative sample of Latinas can be obtained.
- Published
- 2010
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