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2,753 results on '"Muller, G"'

3. Diffusion Processes: entropy, Gibbs states and the continuous time Ruelle operator

Author

Lopes, A. O., Muller, G., and Neumann, A.

Subjects
Mathematics - Probability, Condensed Matter - Statistical Mechanics, Mathematical Physics, Mathematics - Dynamical Systems, 60J25, 60J60, 60J65, 58J65, 37D35
Abstract

We consider a Riemmaniann compact manifold $M$, the associated Laplacian $\Delta$ and the corresponding Brownian motion $X_t$, $t\geq 0.$ Given a Lipschitz function $V:M\to\mathbb R$ we consider the operator $\frac{1}{2}\Delta+V$, which acts on differentiable functions $f: M\to\mathbb R$ via the operator $$\frac{1}{2} \Delta f(x)+\,V(x)f(x) ,$$ for all $x\in M$. Denote by $P_t^V$, $t \geq 0,$ the semigroup acting on functions $f: M\to\mathbb R$ given by $$P_{t}^V (f)(x)\,:=\, \mathbb E_{x} \big[e^{\int_0^{t} V(X_r)\,dr} f(X_t)\big].\,$$ We will show that this semigroup is a continuous-time version of the discrete-time Ruelle operator. Consider the positive differentiable eigenfunction $F: M \to \mathbb{R}$ associated to the main eigenvalue $\lambda$ for the semigroup $P_t^V$, $t \geq 0$. From the function $F$, in a procedure similar to the one used in the case of discrete-time Thermodynamic Formalism, we can associate via a coboundary procedure a certain stationary Markov semigroup. The probability on the Skhorohod space obtained from this new stationary Markov semigroup can be seen as a stationary Gibbs state associated with the potential $V$. We define entropy, pressure, the continuous-time Ruelle operator and we present a variational principle of pressure for such a setting., Comment: In section 3 we present a more precise version of what is necessary to use in the previous part of the text

Published
2022

4. Thermodynamic Formalism on the Skorokhod space: the continuous time Ruelle operator, entropy, pressure, entropy production and expansiveness

Author

Knorst, J., Lopes, A. O., Muller, G., and Neumann, A.

Subjects
Mathematics - Dynamical Systems, Condensed Matter - Statistical Mechanics, Mathematical Physics, Mathematics - Probability, 37A50, 37A10, 37A60, 37D35, 60G10, 60J25, 82B05, 82B30
Abstract

Consider the semi-flow given by the continuous time shift $\Theta_t:\mathcal{D} \to \mathcal{D} $, $t \geq 0$, acting on the $\mathcal{D} $ of \textit{c\`{a}dl\`{a}g} paths $w: [0,\infty) \to S^1$, where $S^1$ is the unitary circle. We equip the space $\mathcal{D} $ with the Skorokhod metric, and we show that the semi-flow is expanding. We also introduce a stochastic semi-group $e^{t\, L}$, $t \geq 0,$ where $L$ acts linearly on continuous functions $f:S^1\to\mathbb{R}$. This stochastic semigroup and an initial vector of probability $\pi$ define an associated stationary shift-invariant probability $\mathbb{P}$ on the Polish space $\mathcal{D} $. Given such $\mathbb{P}$ and an H\"older potential $V:S^1 \to \mathbb{R}$, we define a continuous time Ruelle operator, which is described by a family of linear operators $ \mathbb{L}^t_V$, $t\geq 0,$ acting on continuous functions $\varphi: S^1 \to \mathbb{R}$. More precisely, given any H\"older $V$ and $t\geq 0$, the operator $ \mathbb{L}^t_V$, is defined by $\varphi \to \psi(y) = \mathbb{L}^t_V(\varphi)(y)= \int_{w(t)=y} e^{ \int_0^t V(w(s)) ds} \varphi (w(0)) d \mathbb{P}(w).$ For some specific parameters we show the existence of an eigenvalue $\lambda_V$ and an associated H\"older eigenfunction $\varphi_V>0$.After a coboundary procedure we obtain another stochastic semigroup, with infinitesimal generator $L_V$, and this will define a new probability $\mathbb{P}_V$ on $\mathcal{D}$, which we call the Gibbs (or, equilibrium) probability for the potential $V$. In this case, we define entropy for some shift-invariant probabilities on $\mathcal{D}$, and we consider a variational problem of pressure. Finally, we define entropy production and present our main result: we analyze its relation with time-reversal and symmetry of $L$. We also show that the continuous-time shift $\Theta_t$, acting on the Skorohod space $D$, is expanding., Comment: We made some changes to the material from the last submission. See new Appendix 3

Published
2022

7. Search for High-energy Neutrinos from Binary Neutron Star Merger GW170817 with ANTARES, IceCube, and the Pierre Auger Observatory

Author

Albert, A., Andre, M., Anghinolfi, M., Ardid, M., Aubert, J. -J., Aublin, J., Avgitas, T., Baret, B., Barrios-Marti, J., Basa, S., Belhorma, B., Bertin, V., Biagi, S., Bormuth, R., Bourret, S., Bouwhuis, M. C., Branzacs, H., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Moursli, R. Cherkaoui El, Chiarusi, T., Circella, M., Coelho, J. A. B., Coleiro, A., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Diaz, A. F., Deschamps, A., De Bonis, G., Distefano, C., Di Palma, I., Domi, A., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., Bojaddaini, I. El, Khayati, N. El, Elsasser, D., Enzenhofer, A., Ettahiri, A., Fassi, F., Felis, I., Fusco, L. A., Gay, P., Giordano, V., Glotin, H., Gregoire, T., Ruiz, R. Gracia, Graf, K., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Y., Hernandez-Rey, J. J., Hossl, J., Hofestadt, J., Illuminati, G., James, C. W., de Jong, M., Jongen, M., Kadler, M., Kalekin, O., Katz, U., Kiessling, D., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lachaud, C., Lahmann, R., Lefèvre, D., Leonora, E., Lotze, M., Loucatos, S., Marcelin, M., Margiotta, A., Marinelli, A., Martinez-Mora, J. A., Mele, R., Melis, K., Michael, T., Migliozzi, P., Moussa, A., Navas, S., Nezri, E., Organokov, M., Puavualacs, G. E., Pellegrino, C., Perrina, C., Piattelli, P., Popa, V., Pradier, T., Quinn, L., Racca, C., Riccobene, G., Sanchez-Losa, A., Saldaña, M., Salvadori, I., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schussler, F., Sieger, C., Spurio, M., Stolarczyk, Th., Taiuti, M., Tayalati, Y., Trovato, A., Turpin, D., Tonnis, C., Vallage, B., Van Elewyck, V., Versari, F., Vivolo, D., Vizzoca, A., Wilms, J., Zornoza, J. D., Zuñiga, J., Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Samarai, I. Al, Altmann, D., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Arguelles, C., Auffenberg, J., Axani, S., Bagherpour, H., Bai, X., Barron, J. P., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Becker, K. -H., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Borner, M., Bos, F., Bose, D., Boser, S., Botner, O., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Brayeur, L., Brenzke, M., Bretz, H. -P., Bron, S., Brostean-Kaiser, J., Burgman, A., Carver, T., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Clark, K., Classen, L., Coenders, S., Collin, G. H., Conrad, J. M., Cowen, D. F., Cross, R., Day, M., de Andre, J. P. A. M., De Clercq, C., DeLaunay, J. J., Dembinski, H., De Ridder, S., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Diaz-Velez, J. C., di Lorenzo, V., Dujmovic, H., Dumm, J. P., Dunkman, M., Dvorak, E., Eberhardt, B., Ehrhardt, T., Eichmann, B., Eller, P., Evenson, P. A., Fahey, S., Fazely, A. R., Felde, J., Filimonov, K., Finley, C., Flis, S., Franckowiak, A., Friedman, E., Fuchs, T., Gaisser, T. K., Gallagher, J., Gerhardt, L., Ghorbani, K., Giang, W., Glauch, T., Glusenkamp, T., Goldschmidt, A., Gonzalez, J. G., Grant, D., Griffith, Z., Haack, C., Hallgren, A., Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Helbing, K., Hellauer, R., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Hultqvist, K., Hunnefeld, M., In, S., Ishihara, A., Jacobi, E., Japaridze, G. S., Jeong, M., Jero, K., Jones, B. J. P., Kalaczynski, P., Kang, W., Kappes, A., Karg, T., Karle, A., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kim, J., Kim, M., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Kohnen, G., Koirala, R., Kolanoski, H., Kopke, L., Kopper, C., Kopper, S., Koschinsky, J. P., Koskinen, D. J., Kowalski, M., Krings, K., Kroll, M., Kruckl, G., Kunnen, J., Kunwar, S., Kurahashi, N., Kuwabara, T., Kyriacou, A., Labare, M., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lesiak-Bzdak, M., Leuermann, M., Liu, Q. R., Lu, L., Lunemann, J., Luszczak, W., Madsen, J., Maggi, G., Mahn, K. B. M., Mancina, S., Maruyama, R., Mase, K., Maunu, R., McNally, F., Meagher, K., Medici, M., Meier, M., Menne, T., Merino, G., Meures, T., Miarecki, S., Micallef, J., Momente, G., Montaruli, T., Moore, R. W., Moulai, M., Nahnhauer, R., Nakarmi, P., Naumann, U., Neer, G., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Olivas, A., O'Murchadha, A., Palczewski, T., Pandya, H., Pankova, D. V., Peiffer, P., Pepper, J. A., Heros, C. Perez de los, Pieloth, D., Pinat, E., Plum, M., Pranav, D., Price, P. B., Przybylski, G. T., Raab, C., Radel, L., Rameez, M., Rawlins, K., Rea, I. C., Reimann, R., Relethford, B., Relich, M., Resconi, E., Rhode, W., Richman, M., Robertson, S., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk, D., Salzer, T., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Schlunder, P., Schmidt, T., Schneider, A., Schoenen, S., Schoneberg, S., Schumacher, L., Seckel, D., Seunarine, S., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stasik, A., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stossl, A., Strotjohann, N. L., Stuttard, T., Sullivan, G. W., Sutherland, M., Taboada, I., Tatar, J., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tevsic, G., Tilav, S., Toale, P. A., Tobin, M. N., Toscano, S., Tosi, D., Tselengidou, M., Tung, C. F., Turcati, A., Turley, C. F., Ty, B., Unger, E., Usner, M., Vandenbroucke, J., Van Driessche, W., van Eijndhoven, N., Vanheule, S., van Santen, J., Vehring, M., Vogel, E., Vraeghe, M., Walck, C., Wallace, A., Wallraff, M., Wandler, F. D., Wandkowsky, N., Waza, A., Weaver, C., Weiss, M. J., Wendt, C., Werthebach, J., Westerhoff, S., Whelan, B. J., Wiebe, K., Wiebusch, C. H., Wille, L., Williams, D. R., Wills, L., Wolf, M., Wood, J., Wood, T. R., Woolsey, E., Woschnagg, K., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Yuan, T., Zoll, M., Aab, A., Abreu, P., Aglietta, M., Albuquerque, I. F. M., Albury, J. M., Allekotte, I., Almela, A., Castillo, J. Alvarez, Alvarez-Muñiz, J., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arsene, N., Asorey, H., Assis, P., Avila, G., Badescu, A. M., Balaceanu, A., Barbato, F., Luz, R. J. Barreira, Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Bohavcova, M., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, L., Cancio, A., Canfora, F., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Chavez, A. G., Chinellato, J. A., Chudoba, J., Clay, R. W., Cerutti, A. C. Cobos, Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceiccão, R., Consolati, G., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., Day, J. A., de Almeida, R. M., de Jong, S. J., De Mauro, G., Neto, J. R. T. de Mello, De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., Deligny, O., Castro, M. L. Diaz, Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorosti, Q., Anjos, R. C. dos, Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzini, N., Feldbusch, F., Fenu, F., Fick, B., Figueira, J. M., Filipvcivc, A., Freire, M. M., Fujii, T., Fuster, A., Gaior, R., Garcia, B., Gate, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Glas, D., Glaser, C., Golup, G., Berisso, M. Gomez, Vitale, P. F. Gomez, Gonzalez, N., Gorgi, A., Gottowik, M., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Halliday, R., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hojvat, C., Holt, E., Homola, P., Horandel, J. R., Horvath, P., Hrabovsky, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Johnsen, J. A., Josebachuili, M., Jurysek, J., Kaapa, A., Kampert, K. H., Keilhauer, B., Kemmerich, N., Kemp, J., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Mezek, G. Kukec, Kunka, N., Awad, A. Kuotb, Lago, B. L., LaHurd, D., Lang, R. G., Lauscher, M., Legumina, R., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Presti, D. Lo, Lopes, L., Lopez, R., Casado, A. Lopez, Lorek, R., Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Marics, I. C., Marsella, G., Martello, D., Martinez, H., Bravo, O. Martinez, Meza, J. J. Masias, Mathes, H. J., Mathys, S., Matthews, J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melo, D., Menshikov, A., Merenda, K. -D., Michal, S., Micheletti, M. I., Middendorf, L., Miramonti, L., Mitrica, B., Mockler, D., Mollerach, S., Montanet, F., Morello, C., Morlino, G., Mostafa, M., Muller, A. L., Muller, G., Muller, M. A., Muller, S., Mussa, R., Naranjo, I., Nellen, L., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Novzka, L., Nuñez, L. A., Oikonomou, F., Olinto, A., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pcekala, J., Pelayo, R., Peña-Rodriguez, J., Pereira, L. A. S., Perlin, M., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Pierog, T., Pimenta, M., Pirronello, V., Platino, M., Poh, J., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos-Pollan, R., Rautenberg, J., Ravignani, D., Ridky, J., Riehn, F., Risse, M., Ristori, P., Rizi, V., de Carvalho, W. Rodrigues, Fernandez, G. Rodriguez, Rojo, J. Rodriguez, Roncoroni, M. J., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saffi, S. J., Saftoiu, A., Salamida, F., Salazar, H., Saleh, A., Salina, G., Sanchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento-Cano, C., Sato, R., Schauer, M., Scherini, V., Schieler, H., Schimp, M., Schmidt, D., Scholten, O., Schovanek, P., Schroder, F. G., Schroder, S., Schulz, A., Schumacher, J., Sciutto, S. J., Segreto, A., Shadkam, A., Shellard, R. C., Sigl, G., Silli, G., Šmida, R., Snow, G. R., Sommers, P., Sonntag, S., Soriano, J. F., Squartini, R., Stanca, D., Stanivc, S., Stasielak, J., Stassi, P., Stolpovskiy, M., Strafella, F., Streich, A., Suarez, F., Duran, M. Suarez, Sudholz, T., Suomijarvi, T., Supanitsky, A. D., Šupik, J., Swain, J., Szadkowski, Z., Taboada, A., Taborda, O. A., Timmermans, C., Peixoto, C. J. Todero, Tomankova, L., Tome, B., Elipe, G. Torralba, Travnicek, P., Trini, M., Tueros, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdes, no, I. Vali, Valore, L., van Aar, G., van Bodegom, P., Berg, A. M. van den, van Vliet, A., Varela, E., Cardenas, B. Vargas, Vazquez, R. A., Veberivc, D., Ventura, C., Quispe, I. D. Vergara, Verzi, V., Vicha, J., nor, L. Villase, Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiedenski, M., Wiencke, L., Wilczynski, H., Wirtz, M., Wittkowski, D., Wundheiler, B., Yang, L., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., Zuccarello, F., Abbott, B. P., Abbott, R., Abbott, T. D., Acernese, F., Ackley, K., Adams, C., Adams, T., Addesso, P., Adhikari, R. X., Adya, V. B., Affeldt, C., Afrough, M., Agarwal, B., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Allen, B., Allen, G., Allocca, A., Altin, P. A., Amato, A., Ananyeva, A., Anderson, S. B., Anderson, W. G., Angelova, S. V., Antier, S., Appert, S., Arai, K., Araya, M. C., Areeda, J. S., Arnaud, N., Arun, K. G., Ascenzi, S., Ashton, G., Ast, M., Aston, S. M., Astone, P., Atallah, D. V., Aufmuth, P., Aulbert, C., AultONeal, K., Austin, C., Avila-Alvarez, A., Babak, S., Bacon, P., Bader, M. K. M., Bae, S., Baker, P. T., Baldaccini, F., Ballardin, G., Ballmer, S. W., Banagiri, S., Barayoga, J. C., Barclay, S. E., Barish, B. C., Barker, D., Barkett, K., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Bartos, I., Bassiri, R., Basti, A., Batch, J. C., Bawaj, M., Bayley, J. C., Bazzan, M., Becsy, B., Beer, C., Bejger, M., Belahcene, I., Bell, A. S., Berger, B. K., Bergmann, G., Bero, J. J., Berry, C. P. L., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhagwat, S., Bhandare, R., Bilenko, I. A., Billingsley, G., Billman, C. R., Birch, J., Birney, R., Birnholtz, O., Biscans, S., Biscoveanu, S., Bisht, A., Bitossi, M., Biwer, C., Bizouard, M. A., Blackburn, J. K., Blackman, J., Blair, C. D., Blair, D. G., Blair, R. M., Bloemen, S., Bock, O., Bode, N., Boer, M., Bogaert, G., Bohe, A., Bondu, F., Bonilla, E., Bonnand, R., Boom, B. A., Bork, R., Boschi, V., Bose, S., Bossie, K., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Branchesi, M., Brau, J. E., Briant, T., Brillet, A., Brinkmann, M., Brisson, V., Brockill, P., Broida, J. E., Brooks, A. F., Brown, D. A., Brown, D. D., Brunett, S., Buchanan, C. C., Buikema, A., Bulik, T., Bulten, H. J., Buonanno, A., Buskulic, D., Buy, C., Byer, R. L., Cabero, M., Cadonati, L., Cagnoli, G., Cahillane, C., Bustillo, J. Calderon, Callister, T. A., Calloni, E., Camp, J. B., Canepa, M., Canizares, P., Cannon, K. C., Cao, H., Cao, J., Capano, C. D., Capocasa, E., Carbognani, F., Caride, S., Carney, M. F., Diaz, J. Casanueva, Casentini, C., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Cella, G., Cepeda, C. B., Cerda-Duran, P., Cerretani, G., Cesarini, E., Chamberlin, S. J., Chan, M., Chao, S., Charlton, P., Chase, E., Chassande-Mottin, E., Chatterjee, D., Cheeseboro, B. D., Chen, H. 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E., and Zweizig, J.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The Advanced LIGO and Advanced Virgo observatories recently discovered gravitational waves from a binary neutron star inspiral. A short gamma-ray burst (GRB) that followed the merger of this binary was also recorded by the Fermi Gamma-ray Burst Monitor (Fermi-GBM), and the Anticoincidence Shield for the Spectrometer for the International Gamma-Ray Astrophysics Laboratory (INTEGRAL), indicating particle acceleration by the source. The precise location of the event was determined by optical detections of emission following the merger. We searched for high-energy neutrinos from the merger in the GeV--EeV energy range using the ANTARES, IceCube, and Pierre Auger Observatories. No neutrinos directionally coincident with the source were detected within $\pm500$ s around the merger time. Additionally, no MeV neutrino burst signal was detected coincident with the merger. We further carried out an extended search in the direction of the source for high-energy neutrinos within the 14-day period following the merger, but found no evidence of emission. We used these results to probe dissipation mechanisms in relativistic outflows driven by the binary neutron star merger. The non-detection is consistent with model predictions of short GRBs observed at a large off-axis angle., Comment: 22 pages, 2 figures

Published
2017
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8. EXPRES: A Next Generation RV Spectrograph in the Search for Earth-like Worlds

Author

Jurgenson, C., Fischer, D., McCracken, T., Sawyer, D., Szymkowiak, A., Davis, A. B., Muller, G., and Santoro, F.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The EXtreme PREcision Spectrograph (EXPRES) is an optical fiber fed echelle instrument being designed and built at the Yale Exoplanet Laboratory to be installed on the 4.3-meter Discovery Channel Telescope operated by Lowell Observatory. The primary science driver for EXPRES is to detect Earth-like worlds around Sun-like stars. With this in mind, we are designing the spectrograph to have an instrumental precision of 15 cm/s so that the on-sky measurement precision (that includes modeling for RV noise from the star) can reach to better than 30 cm/s. This goal places challenging requirements on every aspect of the instrument development, including optomechanical design, environmental control, image stabilization, wavelength calibration, and data analysis. In this paper we describe our error budget, and instrument optomechanical design., Comment: 20 pages, 20 figures, SPIE Astronomical Telescopes & Instrumentation proceedings paper

Published
2016
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10. LSST optical beam simulator

Author

Tyson, J. A., Sasian, J., Gilmore, K., Bradshaw, A., Claver, C., Klint, M., Muller, G., Poczulp, G., and Resseguie, E.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We describe a camera beam simulator for the LSST which is capable of illuminating a 60mm field at f/1.2 with realistic astronomical scenes, enabling studies of CCD astrometric and photometric performance. The goal is to fully simulate LSST observing, in order to characterize charge transport and other features in the thick fully depleted CCDs and to probe low level systematics under realistic conditions. The automated system simulates the centrally obscured LSST beam and sky scenes, including the spectral shape of the night sky. The doubly telecentric design uses a nearly unit magnification design consisting of a spherical mirror, three BK7 lenses, and one beam-splitter window. To achieve the relatively large field the beam-splitter window is used twice. The motivation for this LSST beam test facility was driven by the need to fully characterize a new generation of thick fully-depleted CCDs, and assess their suitability for the broad range of science which is planned for LSST. Due to the fast beam illumination and the thick silicon design [each pixel is 10 microns wide and over 100 microns deep] at long wavelengths there can be effects of photon transport and charge transport in the high purity silicon. The focal surface covers a field more than sufficient for a 40x40 mm LSST CCD. Delivered optical quality meets design goals, with 50% energy within a 5 micron circle. The tests of CCD performance are briefly described., Comment: 9 pages, 9 figures

Published
2014
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11. Highlights from the Pierre Auger Observatory

Author

Letessier-Selvon, Antoine, Aab, A., Abreu, P., Aglietta, M., Ahlers, M., Ahn, E. J., Albuquerque, I. F. M., Allekotte, I., Allen, J., Allison, P., Almela, A., Castillo, J. Alvarez, Alvarez-Muniz, J., Batista, R. Alves, Ambrosio, M., Aminaei, A., Anchordoqui, L., Andringa, S., Antivcic, T., Aramo, C., Arqueros, F., Asorey, H., Assis, P., Aublin, J., Ave, M., Avenier, M., Avila, G., Badescu, A. M., Barber, K. B., Bardenet, R., Baeuml, J., Baus, C., Beatty, J. J., Becker, K. H., Belletoile, A., Bellido, J. A., BenZvi, S., Berat, C., Bertou, X., Biermann, P. L., Billoir, P., Blanco, F., Blanco, M., Bleve, C., Blumer, H., Bohacova, M., Boncioli, D., Bonifazi, C., Bonino, R., Borodai, N., Brack, J., Brancus, I., Brogueira, P., Brown, W. C., Buchholz, P., Bueno, A., Burton, R. E., Buscemi, M., Caballero-Mora, K. S., Caccianiga, B., Caccianiga, L., Candusso, M., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Cheng, S. H., Chiavassa, A., Chinellato, J. A., Chudoba, J., Cilmo, M., Clay, R. W., Cocciolo, G., Colalillo, R., Collica, L., Coluccia, M. R., Conceicao, R., Contreras, F., Cook, H., Cooper, M. J., Coutu, S., Covault, C. E., Criss, A., Cronin, J., Curutiu, A., Dallier, R., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., De Domenico, M., de Jong, S. J., De La Vega, G., Junior, W. J. M. de Mello, Neto, J. R. T. de Mello, De Mitri, I., de Souza, V., de Vries, K. D., del Peral, L., Deligny, O., Dembinski, H., Dhital, N., Di Giulio, C., Diaz, J. C., Castro, M. L. Diaz, Diep, P. N., Diogo, F., Dobrigkeit, C., Docters, W., D'Olivo, J. C., Dong, P. N., Dorofeev, A., Anjos, J. C. dos, Dova, M. T., Ebr, J., Engel, R., Erdmann, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Luis, P. Facal San, Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Ferguson, A. P., Fick, B., Figueira, J. M., Filevich, A., Filipcic, A., Foerster, N., Fox, B. D., Fracchiolla, C. E., Fraenkel, E. D., Fratu, O., Frohlich, U., Fuchs, B., Gaior, R., Gamarra, R. F., Gambetta, S., Garcia, B., Roca, S. T. Garcia, Garcia-Gamez, D., Garcia-Pinto, D., Garilli, G., Bravo, A. Gascon, Gemmeke, H., Ghia, P. L., Giller, M., Gitto, J., Glaser, C., Glass, H., Albarracin, F. Gomez, Berisso, M. Gomez, Vitale, P. F. Gomez, Goncalves, P., Gonzalez, J. G., Gookin, B., Gorgi, A., Gorham, P., Gouffon, P., Grebe, S., Griffith, N., Grillo, A. F., Grubb, T. D., Guardincerri, Y., Guarino, F., Guedes, G. P., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Haungs, A., Hebbeker, T., Heck, D., Herve, A. E., Hill, G. C., Hojvat, C., Hollon, N., Homola, P., Hoerandel, J. R., Horvath, P., Hrabovsky, M., Huber, D., Huege, T., Insolia, A., Isar, P. G., Jansen, S., Jarne, C., Josebachuili, M., Kadija, K., Kambeitz, O., Kampert, K. H., Karhan, P., Kasper, P., Katkov, I., Kegl, B., Keilhauer, B., Keivani, A., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., d, J. Knapp, Krause, R., Krohm, N., Kroemer, O., Kruppke-Hansen, D., Kuempel, D., Kunka, N., La Rosa, G., LaHurd, D., Latronico, L., Lauer, R., Lauscher, M., Lautridou, P., Coz, S. Le, Leao, M. S. A. B., Lebrun, D., Lebrun, P., de Oliveira, M. A. Leigui, Lhenry-Yvon, I., Link, K., Lopez, R., Aguera, A. Lopez, Louedec, K., Bahilo, J. Lozano, Lu, L., Lucero, A., Ludwig, M., Lyberis, H., Maccarone, M. C., Macolino, C., Malacari, M., Maldera, S., Maller, J., Mandat, D., Mantsch, P., Mariazzi, A. G., Marin, V., Maris, I. C., Falcon, H. R. Marquez, Marsella, G., Martello, D., Martin, L., Martinez, H., Bravo, O. Martinez, Martraire, D., Meza, J. J. Masias, Mathes, H. J., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurel, D., Maurizio, D., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melissas, M., Melo, D., Menichetti, E., Menshikov, A., Messina, S., Meyhandan, R., Micanovic, S., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Molina-Bueno, L., Mollerach, S., Monasor, M., Ragaigne, D. Monnier, Montanet, F., Morales, B., Morello, C., Moreno, J. C., Mostafa, M., Moura, C. A., Muller, M. A., Muller, G., Munchmeyer, M., Mussa, R., Navarra, G., Navarro, J. L., Navas, S., Necesal, P., Nellen, L., Nelles, A., Neuser, J., Nhung, P. T., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novzka, L., Oehlschlager, J., Olinto, A., Oliveira, M., Ortiz, M., Pacheco, N., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Palmieri, N., Parente, G., Parra, A., Pastor, S., Paul, T., Pech, M., Pekala, J., Pelayo, R., Pepe, I. M., Perrone, L., Pesce, R., Petermann, E., Petrera, S., Petrolini, A., Petrov, Y., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Pontz, M., Porcelli, A., Preda, T., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Rautenberg, J., Ravel, O., Ravignani, D., Revenu, B., Ridky, J., Riggi, S., Risse, M., Ristori, P., Rivera, H., Rizi, V., Roberts, J., de Carvalho, W. Rodrigues, Cabo, I. Rodriguez, Fernandez, G. Rodriguez, Martino, J. Rodriguez, Rojo, J. Rodriguez, Rodriguez-Frias, M. D., Ros, G., Rosado, J., Rossler, T., Roth, M., Rouille-d'Orfeuil, B., Roulet, E., Rovero, A. C., Ruhle, C., Saffi, S. J., Saftoiu, A., Salamida, F., Salazar, H., Greus, F. Salesa, Salina, G., Sanchez, F., Sanchez-Lucas, P., Santo, C. E., Santos, E., Santos, E. M., Sarazin, F., Sarkar, B., Sato, R., Scharf, N., Scherini, V., Schieler, H., Schiffer, P., Schmidt, A., Scholten, O., Schoorlemmer, H., Schovanek, P., Schroeder, F. G., Schulz, A., Schulz, J., Sciutto, S. J., Scuderi, M., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sidelnik, I., Sigl, G., Sima, O., Smialkowski, A., Smida, R., Snow, G. R., Sommers, P., Sorokin, J., Spinka, H., Squartini, R., Srivastava, Y. N., Stanic, S., Stapleton, J., Stasielak, J., Stephan, M., Straub, M., Stutz, A., Suarez, F., Suomijarvi, T., Supanitsky, A. D., Susa, T., Sutherland, M. S., Swain, J., Szadkowski, Z., Szuba, M., Tapia, A., Tartare, M., Tacscuau, O., Tcaciuc, R., Thao, N. T., Tiffenberg, J., Timmermans, C., Tkaczyk, W., Peixoto, C. J. Todero, Toma, G., Tomankova, L., Tome, B., Tonachini, A., Elipe, G. Torralba, Machado, D. Torres, Travnicek, P., Tridapalli, D. B., Trovato, E., Tueros, M., Ulrich, R., Unger, M., Galicia, J. F. Valdes, Valino, I., Valore, L., van Aar, G., Berg, A. M. van den, van Velzen, S., van Vliet, A., Varela, E., Cardenas, B. Vargas, Varner, G., Vazquez, J. R., Vazquez, R. A., Veberic, D., Verzi, V., Vicha, J., Videla, M., Villasenor, L., Wahlberg, H., Wahrlich, P., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weidenhaupt, K., Weindl, A., Werner, F., Westerhoff, S., Whelan, B. J., Widom, A., Wieczorek, G., Wiencke, L., Wilczynska, B., Wilczynski, H., Will, M., Williams, C., Winchen, T., Wundheiler, B., Wykes, S., Yamamoto, T., Yapici, T., Younk, P., Yuan, G., Yushkov, A., Zamorano, B., Zas, E., Zavrtanik, D., Zavrtanik, M., Zaw, I., Zepeda, A., Zhou, J., Zhu, Y., Silva, M. Zimbres, and Ziolkowski, M.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The Pierre Auger Observatory is the world's largest cosmic ray observatory. Our current exposure reaches nearly 40,000 km$^2$ str and provides us with an unprecedented quality data set. The performance and stability of the detectors and their enhancements are described. Data analyses have led to a number of major breakthroughs. Among these we discuss the energy spectrum and the searches for large-scale anisotropies. We present analyses of our X$_{max}$ data and show how it can be interpreted in terms of mass composition. We also describe some new analyses that extract mass sensitive parameters from the 100% duty cycle SD data. A coherent interpretation of all these recent results opens new directions. The consequences regarding the cosmic ray composition and the properties of UHECR sources are briefly discussed., Comment: 9 pages, 12 figures, talk given at the 33rd International Cosmic Ray Conference, Rio de Janeiro 2013

Published
2013
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12. Pierre Auger Observatory and Telescope Array: Joint Contributions to the 33rd International Cosmic Ray Conference (ICRC 2013)

Author

Array, The Telescope, Collaborations, Pierre Auger, Abu-Zayyad, T., Allen, M., Anderson, R., Azuma, R., Barcikowski, E., Belz, J. W, Bergman, D. R., Blake, S. A., Cady, R., Chae, M. J., Cheon, B. G., Chiba, J., Chikawa, M., Cho, W. R., Fujii, T., Fukushima, M., Goto, K., Hanlon, W., Hayashi, Y., Hayashida, N., Hibino, K., Honda, K., Ikeda, D., Inoue, N., Ishii, T., Ishimori, R., Ito, H., Ivanov, D., Jui, C. C. H., Kadota, K., Kakimoto, F., Kalashev, O., Kasahara, K., Kawai, H., Kawakami, S., Kawana, S., Kawata, K., Kido, E., Kim, H. B., Kim, J. H., Kitamura, S., Kitamura, Y., Kuzmin, V., Kwon, Y. J., Lan, J., Lundquist, J. P., Machida, K., Martens, K., Matsuda, T., Matsuyama, T., Matthews, J. N., Minamino, M., Mukai, K., Myers, I., Nagasawa, K., Nagataki, S., Nakamura, T., Nanpei, H., Nonaka, T., Nozato, A., Ogio, S., Oh, S., Ohnishi, M., Ohoka, H., Oki, K., Okuda, T., Ono, M., Oshima, A., Ozawa, S., Park, I. H., Pshirkov, M. S., Rodriguez, D. C., Rubtsov, G., Ryu, D., Sagawa, H., Sakurai, N., Sampson, A. L., Scott, L. M., Shah, P. D., Shibata, F., Shibata, T., Shimodaira, H., Shin, B. K., Shirahama, T., Smith, J. D., Sokolsky, P., Springer, R. W., Stokes, B. T., Stratton, S. R., Stroman, T. A., Takamura, M., Takeda, M., Taketa, A., Takita, M., Tameda, Y., Tanaka, H., Tanaka, K., Tanaka, M., Thomas, S. B., Thomson, G. B., Tinyakov, P., Tkachev, I., Tokuno, H., Tomida, T., Troitsky, S., Tsunesada, Y., Tsutsumi, K., Uchihori, Y., Udo, S., Urban, F., Vasiloff, G., Wada, Y., Wong, T., Yamaoka, H., Yamazaki, K., Yang, J., Yashiro, K., Yoneda, Y., Yoshida, S., Yoshii, H., Zollinger, R., Zundel, Z., Aab, A., Abreu, P., Aglietta, M., Ahlers, M., Ahn, E. J., Albuquerque, I. F. M., Allekotte, I., Allen, J., Allison, P., Almela, A., Castillo, J. Alvarez, Alvarez-Muniz, J., Batista, R. Alves, Ambrosio, M., Aminaei, A., Anchordoqui, L., Andringa, S., Antivcic, T., Aramo, C., Arqueros, F., Asorey, H., Assis, P., Aublin, J., Ave, M., Avenier, M., Avila, G., Badescu, A. M., Barber, K. B., Bardenet, R., Baeuml, J., Baus, C., Beatty, J. J., Becker, K. H., Belletoile, A., Bellido, J. A., BenZvi, S., Berat, C., Bertou, X., Biermann, P. L., Billoir, P., Blanco, F., Blanco, M., Bleve, C., Blumer, H., Bohacova, M., Boncioli, D., Bonifazi, C., Bonino, R., Borodai, N., Brack, J., Brancus, I., Brogueira, P., Brown, W. C., Buchholz, P., Bueno, A., Burton, R. E., Buscemi, M., Caballero-Mora, K. S., Caccianiga, B., Caccianiga, L., Candusso, M., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Cester, R., Cheng, S. H., Chiavassa, A., Chinellato, J. A., Chudoba, J., Cilmo, M., Clay, R. W., Cocciolo, G., Colalillo, R., Collica, L., Coluccia, M. R., Conceicao, R., Contreras, F., Cook, H., Cooper, M. J., Coutu, S., Covault, C. E., Criss, A., Cronin, J., Curutiu, A., Dallier, R., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., De Domenico, M., de Jong, S. J., De La Vega, G., Junior, W. J. M. de Mello, Neto, J. R. T. de Mello, De Mitri, I., de Souza, V., de Vries, K. D., del Peral, L., Deligny, O., Dembinski, H., Dhital, N., Di Giulio, C., Diaz, J. C., Castro, M. L. Diaz, Diep, P. N., Diogo, F., Dobrigkeit, C., Docters, W., D'Olivo, J. C., Dong, P. N., Dorofeev, A., Anjos, J. C. dos, Dova, M. T., Ebr, J., Engel, R., Erdmann, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Luis, P. Facal San, Falcke, H., Fang, K., Farrar, G., Fauth, A. C., Fazzini, N., Ferguson, A. P., Fick, B., Figueira, J. M., Filevich, A., Filipcic, A., Foerster, N., Fox, B. D., Fracchiolla, C. E., Fraenkel, E. D., Fratu, O., Frohlich, U., Fuchs, B., Gaior, R., Gamarra, R. F., Gambetta, S., Garcia, B., Roca, S. T. Garcia, Garcia-Gamez, D., Garcia-Pinto, D., Garilli, G., Bravo, A. Gascon, Gemmeke, H., Ghia, P. L., Giller, M., Gitto, J., Glaser, C., Glass, H., Albarracin, F. Gomez, Berisso, M. Gomez, Vitale, P. F. Gomez, Goncalves, P., Gonzalez, J. G., Gookin, B., Gorgi, A., Gorham, P., Gouffon, P., Grebe, S., Griffith, N., Grillo, A. F., Grubb, T. D., Guardincerri, Y., Guarino, F., Guedes, G. P., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Haungs, A., Hebbeker, T., Heck, D., Herve, A. E., Hill, G. C., Hojvat, C., Hollon, N., Homola, P., Hoerandel, J. R., Horvath, P., Hrabovsky, M., Huber, D., Huege, T., Insolia, A., Isar, P. G., Jansen, S., Jarne, C., Josebachuili, M., Kadija, K., Kambeitz, O., Kampert, K. H., Karhan, P., Kasper, P., Katkov, I., Kegl, B., Keilhauer, B., Keivani, A., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, J., Krause, R., Krohm, N., Kroemer, O., Kruppke-Hansen, D., Kuempel, D., Kunka, N., La Rosa, G., LaHurd, D., Latronico, L., Lauer, R., Lauscher, M., Lautridou, P., Coz, S. Le, Leao, M. S. A. B., Lebrun, D., Lebrun, P., de Oliveira, M. A. Leigui, Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopez, R., Aguera, A. Lopez, Louedec, K., Bahilo, J. Lozano, Lu, L., Lucero, A., Ludwig, M., Lyberis, H., Maccarone, M. C., Macolino, C., Malacari, M., Maldera, S., Maller, J., Mandat, D., Mantsch, P., Mariazzi, A. G., Marin, V., Maris, I. C., Falcon, H. R. Marquez, Marsella, G., Martello, D., Martin, L., Martinez, H., Bravo, O. Martinez, Martraire, D., Meza, J. J. Masias, Mathes, H. J., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurel, D., Maurizio, D., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melissas, M., Melo, D., Menichetti, E., Menshikov, A., Messina, S., Meyhandan, R., Micanovic, S., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Molina-Bueno, L., Mollerach, S., Monasor, M., Ragaigne, D. Monnier, Montanet, F., Morales, B., Morello, C., Moreno, J. C., Mostafa, M., Moura, C. A., Muller, M. A., Muller, G., Munchmeyer, M., Mussa, R., Navarra, G., Navarro, J. L., Navas, S., Necesal, P., Nellen, L., Nelles, A., Neuser, J., Nhung, P. T., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novzka, L., Oehlschlager, J., Olinto, A., Oliveira, M., Ortiz, M., Pacheco, N., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Palmieri, N., Parente, G., Parra, A., Pastor, S., Paul, T., Pech, M., Pekala, J., Pelayo, R., Pepe, I. M., Perrone, L., Pesce, R., Petermann, E., Petrera, S., Petrolini, A., Petrov, Y., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Pontz, M., Porcelli, A., Preda, T., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Rautenberg, J., Ravel, O., Ravignani, D., Revenu, B., Ridky, J., Riggi, S., Risse, M., Ristori, P., Rivera, H., Rizi, V., Roberts, J., de Carvalho, W. Rodrigues, Cabo, I. Rodriguez, Fernandez, G. Rodriguez, Martino, J. Rodriguez, Rojo, J. Rodriguez, Rodriguez-Frias, M. D., Ros, G., Rosado, J., Rossler, T., Roth, M., Rouille-d'Orfeuil, B., Roulet, E., Rovero, A. C., Ruhle, C., Saffi, S. J., Saftoiu, A., Salamida, F., Salazar, H., Greus, F. Salesa, Salina, G., Sanchez, F., Sanchez-Lucas, P., Santo, C. E., Santos, E., Santos, E. M., Sarazin, F., Sarkar, B., Sato, R., Scharf, N., Scherini, V., Schieler, H., Schiffer, P., Schmidt, A., Scholten, O., Schoorlemmer, H., Schovanek, P., Schroeder, F. G., Schulz, A., Schulz, J., Sciutto, S. J., Scuderi, M., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sidelnik, I., Sigl, G., Sima, O., Smialkowski, A., Smida, R., Snow, G. R., Sommers, P., Sorokin, J., Spinka, H., Squartini, R., Srivastava, Y. N., Stanic, S., Stapleton, J., Stasielak, J., Stephan, M., Straub, M., Stutz, A., Suarez, F., Suomijarvi, T., Supanitsky, A. D., Susa, T., Sutherland, M. S., Swain, J., Szadkowski, Z., Szuba, M., Tapia, A., Tartare, M., Tacscuau, O., Tcaciuc, R., Thao, N. T., Tiffenberg, J., Timmermans, C., Tkaczyk, W., Peixoto, C. J. Todero, Toma, G., Tomankova, L., Tome, B., Tonachini, A., Elipe, G. Torralba, Machado, D. Torres, Travnicek, P., Tridapalli, D. B., Trovato, E., Tueros, M., Ulrich, R., Unger, M., Galicia, J. F. Valdes, Valino, I., Valore, L., van Aar, G., Berg, A. M. van den, van Velzen, S., van Vliet, A., Varela, E., Cardenas, B. Vargas, Varner, G., Vazquez, J. R., Vazquez, R. A., Veberic, D., Verzi, V., Vicha, J., Videla, M., Villasenor, L., Wahlberg, H., Wahrlich, P., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weidenhaupt, K., Weindl, A., Werner, F., Westerhoff, S., Whelan, B. J., Widom, A., Wieczorek, G., Wiencke, L., Wilczynska, B., Wilczynski, H., Will, M., Williams, C., Winchen, T., Wundheiler, B., Wykes, S., Yamamoto, T., Yapici, T., Younk, P., Yuan, G., Yushkov, A., Zamorano, B., Zas, E., Zavrtanik, D., Zavrtanik, M., Zaw, I., Zepeda, A., Zhou, J., Zhu, Y., Silva, M. Zimbres, and Ziolkowski, M.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Joint contributions of the Pierre Auger and Telescope Array Collaborations to the 33rd International Cosmic Ray Conference, Rio de Janeiro, Brazil, July 2013: cross-calibration of the fluorescence telescopes, large scale anisotropies and mass composition., Comment: Joint contributions of the Pierre Auger and Telescope Array Collaborations to the 33rd International Cosmic Ray Conference, Rio de Janeiro, Brazil, July 2013

Published
2013

16. Experimental evidence of two-band behavior of MgB2

Author

Ponomarev, Ya. G., Kuzmichev, S. A., Mikheev, M. G., Sudakova, M. V., Tchesnokov, S. N., Timergaleev, N. Z., Yarigin, A. V., Maksimov, E. G., Krasnosvobodtsev, S. I., Varlashkin, A. V., Hein, M. A., Muller, G., Piel, H., Sevastyanova, L. G., Kravchenko, O. V., Burdina, K. P., and Bulychev, B. M.

Subjects
Condensed Matter - Superconductivity
Abstract

The break-junction tunneling has been systematically investigated in MgB2. Two types of the break-junction contacts have been exploited on the same samples, which demonstrated tunnel contact like (SIS) and point contact like (SnS) behavior. Both of them have shown the existence of the two distinct energy gaps. We have observed also the peculiarities on the I(V)- characteristics related to Leggett's collective mode assisted tunneling. --> Corresponding author address: kuzmichev@mig.phys.msu.ru, Comment: 14 pages, 6 figures, 1 table; corrected typos and figs

Published
2003
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17. Weak hyperon decays in heavy baryon chiral perturbation theory: Renormalization and applications

Author

Borasoy, B. and Muller, G.

Subjects
High Energy Physics - Phenomenology, Nuclear Theory
Abstract

The complete renormalization of the weak Lagrangian to chiral order q^2 in heavy baryon chiral perturbation theory is performed using heat kernel techniques. The results are compared with divergences appearing in the calculation of Feynman graphs for the nonleptonic hyperon decay Lambda -> p pi^- and an estimate for the size of the counterterm contributions to the s-wave amplitudes in nonleptonic hyperon decays is given., Comment: 21 pages, 2 figures

Published
2000
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26. Analyse de classification des uvéites secondaires aux inhibiteurs de check-points et aux inhibiteurs de la voie MAP-kinase (inhibiteurs de BRAF et MEK) à partir des cas issus de la base nationale de pharmacovigilance

Author

Thibault, T., primary, Auvens, C., additional, Rogier, T., additional, Muller, G., additional, Turcu, A., additional, Lecluse, J., additional, Mouries-Martin, S., additional, El Hssaini, N., additional, Rajillah, A., additional, Besancenot, J.F., additional, Dautriche, A., additional, Grandvuillemin, A., additional, and Devilliers, H., additional

Published
2022
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27. Effet médiateur de la fatigue entre les poussées articulaires et l’altération de la qualité de vie au cours du lupus systémique

Author

Thibault, T., primary, Bourredjem, A., additional, Maurier, F., additional, Wahl, D., additional, Muller, G., additional, Aumaître, O., additional, Blaison, G., additional, Pennaforte, J.L., additional, Martin, T., additional, Magy-Bertrand, N., additional, Audia, S., additional, Arnaud, L., additional, Amoura, Z., additional, and Devilliers, H., additional

Published
2022
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28. Long-term (180-day) outcomes in critically ill patients with COVID-19 in the REMAP-CAP randomized clinical trial

Author

Florescu, S, Stanciu, D, Zaharia, M, Kosa, A, Codreanu, D, Kidwai, A, Masood, S, Kaye, C, Coutts, A, MacKay, L, Summers, C, Polgarova, P, Farahi, N, Fox, E, McWilliam, S, Hawcutt, D, Rad, L, O’Malley, L, Whitbread, J, Jones, D, Dore, R, Saunderson, P, Kelsall, O, Cowley, N, Wild, L, Thrush, J, Wood, H, Austin, K, Bélteczki, J, Magyar, I, Fazekas, Á, Kovács, S, Szőke, V, Donnelly, A, Kelly, M, Smyth, N, O’Kane, S, McClintock, D, Warnock, M, Campbell, R, McCallion, E, Azaiz, A, Charron, C, Godement, M, Geri, G, Vieillard-Baron, A, Johnson, P, McKenna, S, Hanley, J, Currie, A, Allen, B, McGoldrick, C, McMaster, M, Mani, A, Mathew, M, Kandeepan, R, Vignesh, C, TV, B, Ramakrishnan, N, James, A, Elvira, E, Jayakumar, D, Pratheema, R, Babu, S, Ebenezer, R, Krishnaoorthy, S, Ranganathan, L, Ganesan, M, Shree, M, Guilder, E, Butler, M, Cowdrey, K-A, Robertson, M, Ali, F, McMahon, E, Duffy, E, Chen, Y, Simmonds, C, McConnochie, R, O’Connor, C, El-Khawas, K, Richardson, A, Hill, D, Commons, R, Abdelkharim, H, Saxena, M, Muteithia, M, Dobell-Brown, K, Jha, R, Kalogirou, M, Ellis, C, Krishnamurthy, V, O’Connor, A, Thurairatnam, S, Mukherjee, D, Kaliappan, A, Vertue, M, Nicholson, A, Riches, J, Maloney, G, Kittridge, L, Solesbury, A, Ramos, A, Collins, D, Brickell, K, Reid, L, Smyth, M, Breen, P, Spain, S, Curley, G, McEvoy, N, Geoghegan, P, Clarke, J, Silversides, J, McGuigan, P, Ward, K, O’Neill, A, Finn, S, Wright, C, Green, J, Collins, É, Knott, C, Smith, J, Boschert, C, Slieker, K, Ewalds, E, Sanders, A, Wittenberg, W, Geurts, H, Poojara, L, Sara, T, Nand, K, Reeve, B, Dechert, W, Phillips, B, Oritz-Ruiz de Gordoa, L, Affleck, J, Shaikh, A, Murray, A, Ramanan, M, Frakking, T, Pinnell, J, Robinson, M, Gledhill, L, Wood, T, Sanghavi, R, Bhonagiri, D, Ford, M, Parikh, HG, Avard, B, Nourse, M, McDonald, B, Edmunds, N, Hoiting, O, Peters, M, Rengers, E, Evers, M, Prinssen, A, Morgan, M, Cole, J, Hill, H, Davies, M, Williams, A, Thomas, E, Davies, R, Wise, M, Grimm, P, Soukup, J, Wetzold, R, Löbel, M, Starke, L, Lellouche, F, Lizotte, P, Declerq, P, Antoine, M, Stephanie, G, Jean-Pierre, E, François, B, Marion, B, Philippe, R, Pourcine, F, Monchi, M, Luis, D, Mercier, R, Sagnier, A, Verrier, N, Caplin, C, Richecoeu, J, Combaux, D, Siami, S, Aparicio, C, Vautier, S, Jeblaoui, A, Lemaire-Brunel, D, D'Aragon, F, Carbonneau, E, Leblond, J, Plantefeve, G, Leparco, C, Contou, D, Fartoukh, M, Courtin, L, Labbe, V, Voiriot, G, Salhi, S, Chassé, M, Carrier, F, Boumahni, D, Benettaib, F, Ghamraoui, A, Sement, A, Gachet, A, Hanisch, A, Haffiane, A, Boivin, A-H, Barreau, A, Guerineau, E, Poupblanc, S, Egreteau, P, Lefevre, M, Bocher, S, Le Loup, G, Le Guen, L, Carn, V, Bertel, M, Antcliffe, D, Templeton, M, Rojo, R, Coghlan, P, Smee, J, Barker, G, Finn, A, Kreb, G, Hoff, U, Hinrichs, C, Nee, J, Mackay, E, Cort, J, Whileman, A, Spencer, T, Spittle, N, Beavis, S, Padmakumar, A, Dale, K, Hawes, J, Moakes, E, Gascoyne, R, Pritchard, K, Stevenson, L, Cooke, J, Nemeth-Roszpopa, K, Gauli, B, Bastola, S, Muller, G, Nay, M-A, Kamel, T, Benzekri, D, Jacquier, S, Runge, I, Mathonnet, A, Barbier, F, Bretagnol, A, Carter, J, Van Der Heyden, K, Mehrtens, J, Morris, A, Morgan, S, Burke, T, Mercier, E, Chartier, D, Salmon, C, Dequin, P-F, Garot, D, Bellemare, D, Cloutier, È, Daher, R, Costerousse, O, Boulanger, M-C, Couillard-Chénard, É, Lauzier, F, Francoeur, C, Francois, B, Gay, A, Anne-Laure, F, Ramali, M, HC, O, Ghosh, A, Osagie, R, Arachchige, M, Hartley, M, Cheung, W, Wong, H, Seigne, P, Eustace, J, O'Callaghan, A-M, O'Brien, F, Bamford, P, Reid, A, Cawley, K, Faulkner, M, Pickering, C, Raj, A, Tsinaslanidis, G, Khade, R, Agha, G, Sekiwala, R, Smith, T, Brewer, C, Gregory, J, Limb, J, Cowton, A, O’Brien, J, Postlethwaite, K, Malakouti, S, Music, E, Ricketts, D, King, A, Clermont, G, Bart, R, Mayr, F, Schoenling, A, Andreae, M, Shetty, V, Brant, E, Malley, B, Donadee, C, Sackrowitz, R, Weissman, A, Yealy, D, Barton, D, Talia, N, Nikitas, N, Wells, C, Lankester, L, McMillan, H, Van den Oever, H, Kruisdijk-Gerritsen, A, Haidar, G, Bain, W, Barbash, I, Fitzpatrick, M, Franz, C, Kitsios, G, Moghbeli, K, Rosborough, B, Shah, F, Suber, T, Pulletz, M, Williams, P, Birch, J, Wiseman, S, Horton, S, Alegria, A, Turki, S, Elsefi, T, Crisp, N, Allen, L, Truman, N, Smith, M, Chukkambotla, S, Goddard, W, Duberley, S, Khan, M, Kazi, A, Simpson, J, Duke, G, Chan, P, Carter, B, Hunter, S, Voigt, I, Schueler, R, Blank, E, Hüning, V, Steffen, M, Goralski, P, Litton, E, Regli, A, Pellicano, S, Palermo, A, Eroglu, E, Bihari, S, Laver, RD, Jin, X, Brown, J, McIntyre, J, French, C, Bates, S, Towns, M, Yang, Y, McGain, F, McCullagh, I, Cairns, T, Hanson, H, Patel, B, Clement, I, Evetts, G, Touma, O, Holland, S, Hodge, C, Taylor, H, Alderman, M, Barnes, N, Da Rocha, J, Smith, C, Brooks, N, Weerasinghe, T, Sinclair, J-A, Abusamra, Y, Doherty, R, Cudlipp, J, Singh, R, Yu, H, Daebis, A, Ng, C, Kendrick, S, Saran, A, Makky, A, Greener, D, Rowe-Leete, L, Edwards, A, Bland, Y, Dolman, R, Foster, T, Laffey, J, McNicholas, B, Scully, M, Casey, S, Kernan, M, Brennan, A, Rangan, R, Tully, R, Corbett, S, McCarthy, A, Duffy, O, Burke, D, Linnett, V, Sanderson, A, Ritzema, J, Wild, H, Lucas, R, Marriott, Y, Andric, Z, Cviljevic, S, Br, R, Zapalac, M, Mirković, G, Khare, D, Pinder, M, Gopinath, A, Kannan, T, Dean, S, Vanmali, P, Depuydt, P, De Waele, J, De Bus, L, Fierens, J, Bracke, S, Vermassen, J, Vermeiren, D, Pugh, R, Lean, R, Qiu, X, Scanlan, J, Evans, A, Davies, G, Lewis, J, Plesnikova, Y, Khoud, A, Coetzee, S, Puxty, K, Cathcart, S, Rimmer, D, Bagot, C, Scott, K, Martin, L, Yusuff, H, Isgro, G, Brightling, C, Bourne, M, Craner, M, Boyles, R, Alexander, B, Roberts, T, Nelli, A, Rosenstein-Sisson, R, Speyer, R, Pech, Y, McCullough, J, Tallott, M, Vazquez-Grande, G, Marten, N, Liu, T, Siddiqui, A, Khanal, S, Amatya, S, Szakmany, T, Cherian, S, Williams, G, James, C, Waters, A, Prout, R, Stedman, R, Davies, L, Pegler, S, Kyeremeh, L, Moorhouse, L, Arbane, G, Marotti, M, Bociek, A, Campos, S, Van Nieuwkoop, K, Ottens, T, Visser, Y, Van den Berg, L, Van der Kraan-Donker, A, Brett, S, Arias, S, Hall, R, Paneru, H, Koirala, S, Paudel, P, Wilson, M, Vaara, S, Pettilä, L, Heinonen, J, Pettilä, V, Jain, S, Gupta, A, Holbrook, C, Antoine, P, Meziani, F, Allam, H, Cattelan, J, Clere-Jehl, R, Helms, J, Kummerlen, C, Merdji, H, Monnier, A, Rahmani, H, Studer, A, Schneider, F, Castelain, V, Morel, G, L’Hotellier, S, Ochin, E, Vanjak, C, Rouge, P, Bendjemar, L, Albert, M, Serri, K, Cavayas, A, Duplaix, M, Williams, V, Catorze, NJTADS, Pereira, TNAL, Ferreira, RMC, Bastos, JMPS, Batista, TMO, Badie, J, Berdaguer, F, Malfroy, S, Mezher, C, Bourgoin, C, Moneger, G, Bouvier, E, Muñoz-Bermúdez, R, Marin-Corral, J, Degracia, A, Gómez, F, López, M, Aceto, R, Aghemo, A, Badalamenti, S, Brunetta, E, Cecconi, M, Ciccarelli, M, Constantini, E, Greco, M, Folci, M, Selmi, C, Voza, A, Henning, J, Bonner, S, Hugill, K, Cirstea, E, Wilkinson, D, Jones, J, Altomy, M, Karlikowski, M, Sutherland, H, Wilhelmsen, E, Woods, J, North, J, Pletz, M, Hagel, S, Ankert, J, Kolanos, S, Bloos, F, Simons, K, Van Zuylen, T, Bouman, A, Kumar, N, Panwar, R, Poulter, A-L, Sunkara, K, Szigligeti, G, Leszkoven, J, Rochwerg, B, Karachi, T, Oczkowski, S, Centofanti, J, Millen, T, Sundaran, D, Hollos, L, Turns, M, Walsh, J, Al Qasim, E, Alswaidan, L, Hegazy, M, Arishi, H, Al Amri, A, AlQahtani, S, Naidu, B, Tlayjeh, H, Hussain, S, Al Enezi, F, Abdukahil, SA, Hopkins, P, Noble, H, O’Reilly, K, Mehta, R, Wong, O, Makanju, E, Rao, D, Sikondari, N, Saha, S, Corcoran, E, Pappa, E, Cockrell, M, Donegan, C, Balaie, M, Nickoleit-Bitzenberger, D, Schaaf, B, Meermeier, W, Prebeg, K, Azzaui, H, Hower, M, Brieger, K-G, Elender, C, Sabelhaus, T, Riepe, A, Akamp, C, Kremling, J, Klein, D, Landsiedel-Mechenbier, E, Laha, S, Verlander, M, Jha, A, Megarbane, B, Voicu, S, Deye, N, Malissin, I, Sutterlin, L, Mrad, A, Lehalleur, A, Naim, G, Nguyen, P, Ekhérian, J-M, Boué, Y, Sidéris, G, Vodovar, D, Guérin, E, Grant, C, Brain, M, Mineall, S, Paramasivam, E, Wilby, E, Ogg, B, Howcroft, C, Aspinwall, A, Charlton, S, Gould, R, Mistry, D, Awan, S, Bedford, C, Carr-Wilkinson, J, Hall, A, Gardiner-Hill, C, Maloney, C, Brunskill, N, Watchorn, O, Hardy, C, Qureshi, H, Flint, N, Nicholson, S, Southin, S, Ghattaoraya, A, Harding, D, O’Halloran, S, Collins, A, Smith, E, Trues, E, Borgatta, B, Turner-Bone, I, Reddy, A, Wilding, L, Wilson, C, Surti, Z, Aneman, A, Miller, J, White, H, Estensen, K, Morrison, L, Sutton, J, Cooper, M, Warnapura, L, Agno, R, Sathianathan, P, Shaw, D, Ijaz, N, Spong, A, Sabaretnam, S, Burns, D, Lang, E, Tate, M, Fischer, R, Biradar, V, Soar, N, Golden, D, Davey, M, Seaman, R, Osborne, A, Bannard-Smith, J, Clark, R, Birchall, K, Henry, J, Pomeroy, F, Quayle, R, Wylie, K, Sukuraman, A, John, M, Sibin, S, Leditschke, A, Finnis, M, Jongebloed, K, Khwaja, K, Campisi, J, Van Vonderen, M, Pietersma, M, Vrolijk, L, Kampschreur, L, Van Gulik, L, Makowski, A, Misztal, B, Haider, S, Liao, A, Squires, R, Oborska, A, Kayani, A, Kalchko-Veyssal, S, Prabakaran, R, Hadebe, B, KalchkoVeyssal, S, Williams, T, Song, R, Morpeth, S, Lai, V, Habraken, H, Stewart, R, Mwaura, E, Mew, L, Wren, L, Willams, F, Sutherland, S-B, Rebello, R, Shehabi, Y, Al-Bassam, W, Hulley, A, Kadam, U, Sathianathan, K, Innes, R, Doble, P, Graham, L, Shovelton, C, Dean, T, Salahuddin, N, Aryal, D, Koirala, K, Rai, N, Luitel, S, Seppelt, I, Whitehead, C, Lowrey, J, Gresham, R, Masters, K, Hamlyn, V, Hawkins, N, Roynon-Reed, A, Cutler, S, Lewis, S, Lazaro, J, Newman, T, Aravindan, L, Asghar, A, Bartholomew, J, Bayne, M, Beddows, S, Birch, C, Brend, M, Byrne, R, Campbell, D, Campbell, H, Chambers, E, Clinton, A, Collins, J, Crawshaw, S, Dawson, LA, Donaldson, K, Drake, C, Dyas, S, Ellis, Y, Gilmour, K, Goodwin, J, Halden, S, Hall, AS, Hanson, J, Harper, H, Harrison, S, Hayes, A, Hodgson, H, Hurford, S-A, Jackson, S, Levett, C, Lock, S, Lockett, T, Logan, M, Lomme, K, Luo, J, Marsh, E, Mguni, N, Monaghan, H, Murphy, S, Muzengi, N, Naz, M, O'Kell, E, Oliver, A, O'Reilly, J, Pearson, K, Porter, D, Potter, A, Rook, C, Rounds, C, Sheffield, J, Shirley, K, Siewersk, C, Skinner, T, Speight, H, Sutu, M, Unsworth, A, Van’t Hoff, W, Walker, S, Williams, H, Williamson, D, Williamson, JD, Duan, E, Tsang, J, Patterson, L, Austin, P, Chapman, S, Cabrelli, L, Fletcher, S, Nortje, J, Fottrell-Gould, D, Randell, G, Stammers, K, Healey, G, Pinto, M, Borrill, Z, Duncan, T, Ustianowski, A, Uriel, A, Eltayeb, A, Alfonso, J, Hey, S, Shaw, J, Fox, C, Lindergard, G, Charles, B, Blackledge, B, Connolly, K, Harris, J, Cuesta, J, Xavier, K, Purohit, D, Elhassan, M, Haldeos, A, Vincent, R, Abdelrazik, M, Jenkins, S, Ganesan, A, Kumar, R, Carter, D, Bakthavatsalam, D, Frater, A, Saleem, M, Everitt, R, Hacking, D, Zaman, M, Elmahi, E, Jones, A, Hall, K, Phillips, M, Terrill, L, Mills, G, Raithatha, A, Bauchmuller, K, Ryalls, K, Harrington, K, Bowler, H, Sall, J, Bourne, R, Gross, J, Massey, N, Adebambo, O, Long, M, Tony, K, Juffermans, N, Koopmans, M, Dujardin, R, Alderink, B, Rowland, M, Hutton, P, Bashyal, A, Davidson, N, Hird, C, Chhablani, M, Phalod, G, Kirkby, A, Archer, S, Netherton, K, Reschreiter, H, Camsooksai, J, Patch, S, Humphrey, C, Flynn, G, Harrington, C, Kruger, P, Walsham, J, Meyer, J, Harward, M, Jones, C, Sathe, S, Roche, L, Davies, E, Skinner, D, Gaylard, J, Newman, J, Pogson, D, Rose, S, Daly, Z, Brimfield, L, Nown, A, Parekh, D, Bergin, C, Bates, M, McGhee, C, Lynch, D, Bhandal, K, Tsakiridou, K, Bamford, A, Cooper, L, Whitehouse, T, Veenith, T, Forster, E, O'Connell, M, Sim, M, Hay, S, Henderson, S, Nygren, M, Valentine, E, Katary, A, Bell, G, Wilcox, L, Mataliotakis, M, Smith, P, Ali, M, Isguzar, A, Phull, M-K, Zaidi, A, Pogreban, T, Rosaroso, L, Harvey, D, Lowe, B, Meredith, M, Ryan, L, Schouten, J, Pickkers, P, Roovers, N, Klop-Riehl, M, Van der Eng, H, Sloots-Cuppen, S, Preijers, L, Van Oosten, N, Moine, P, Heming, N, Maxime, V, Bossard, I, Nicholier, T, Clair, B, Orlikowski, D, Bounab, R, Abdeladim, L, Baker, S, Duroux, M, Ratcliffe, M, Sy, E, Mailman, J, Lee, S, Gupta, C, Kassir, S, López, R, Rodríguez-Gómez, J, Cárcel, S, Carmona, R, De la Fuente, C, Rodriguez, M, Jan Hassing, R, Greven, F, Huijbens, D, Roebers, L, Verheij, H, Miles, H, Attokaran, A, Buehner, U, Williams, E, Chapman, M, O’Connor, S, Glasby, K, Rivett, J, Brown, N, Kutsogiannis, D, Thompson, P, Rooney, K, Rodden, N, Thomson, N, McGlynn, D, Abel, L, Gemmell, L, Sundaram, R, Hornsby, J, Walden, A, Keating, L, Frise, M, Rai, S, Bartley, S, Schuster-Bruce, M, Pitts, S, Miln, R, Purandare, L, Vamplew, L, Dempster, D, Gummadi, M, Dormand, N, Wang, S, Spivey, M, Bean, S, Burt, K, Moore, L, Hammonds, F, Richards, C, Campbell, L, Smyth, K, Day, C, Zitter, L, Benyon, S, Singh, J, Lynch, C, Mikusek, J, Deacon, B, Turner, K, Baker, E, Hickey, J, Champanerkar, S, Aitken, L, LewisProsser, L, Ahmad, N, Wiles, M, Willson, J, Grecu, I, Martin, 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S, Wetherill, B, Brajković, A, Babel, J, Sever, H, Dragija, L, Kušan, I, Dushianthan, A, Cusack, R, De Courcy-Golder, K, Salmon, K, Burnish, R, Smith, S, Ruiz, W, Duke, Z, Johns, M, Male, M, Gladas, K, Virdee, S, Swabe, J, Tomlinson, H, Rohde, G, Grünewaldt, A, Bojunga, J, Petros, S, Kunz, K, Schütze, B, Weismann, D, Frey, A, Drayss, M, Goebeler, ME, Flor, T, Fragner, G, Wahl, N, Totzke, J, Sayehli, C, Hakak, S, Altaf, W, O'Sullivan, M, Murphy, A, Walsh, L, Rega La Valle, A, Bewley, J, Sweet, K, Grimmer, L, Johnson, R, Wyatt, R, Morgan, K, Varghese, S, Willis, J, Stratton, E, Kyle, L, Putensen, D, Drury, K, Skorko, A, Bremmer, P, Ward, G, Bassford, C, Sligl, W, Baig, N, Rewa, O, Bagshaw, S, Basile, K, Stavor, D, Burbee, D, McNamara, A, Wunderley, R, Bensen, N, Adams, P, Vita, T, Buhay, M, Scholl, D, Gilliam, M, Winters, J, Doherty, K, Berryman, E, Ghaffari, M, Marroquin, O, Quinn, K, Garrard, W, Kalchthaler, K, Beard, G, Skrtich, A, Bagavathy, K, Drapola, D, Bryan-Morris, K, Arnold, J, Reynolds, B, Hussain, M, Dunsavage, J, Saiyed, S, Hernandez, E, Goldman, J, Brown, C, Comp, S, Raczek, J, Morris, J, Vargas Jr., J, Weiss, D, Hensley, J, Kochert, E, Wnuk, C, Nemeth, C, Mowery, B, Hutchinson, C, Winters, L, McAdams, D, Walker, G, Minnier, T, Wisniewski, M, Mayak, K, McCreary, E, Bariola, R, Viehman, A, Daley, J, Lopus, A, Schmidhofer, M, Ambrosino, R, Keen, S, Toffalo, S, Stambaugh, M, Trimmer, K, Perri, R, Casali, S, Medva, R, Massar, B, Beyerl, A, Burkey, J, Keeler, S, Lowery, M, Oncea, L, Daugherty, J, Sevilla, C, Woelke, A, Dice, J, Weber, L, Roth, J, Ferringer, C, Beer, D, Fesz, J, Carpio, L, Colin, G, Zinzoni, V, Maquigneau, N, Henri-Lagarrigue, M, Pouplet, C, Reill, L, Distler, M, Maselli, A, Martynoga, R, Trask, K, Butler, A, Attwood, B, Parsons, P, Campbell, B, Smith, A, Page, V, Zhao, X, Oza, D, Abrahamson, G, Sheath, B, Young, P, Young, C, Lesona, E, Navarra, L, Cruz, R, Delaney, K, Aguilar-Dano, A, Gojanovic, M, Rhodes, J, Anderson, T, Morris, S, Nayyar, V, Bowen, D, Kong, J, Joy, J, Fuchs, R, Lambert, B, Tai, C, Thomas, A, Keen, A, Tierney, C, Omer, N, Bacon, G, Tridente, A, Shuker, K, Anders, J, Greer, S, Scott, P, Millington, A, Buchanan, P, Binnie, A, Powell, E, McMillan, A, Luk, T, Aref, N, Denmade, C, Sadera, G, Jacob, R, Hughes, D, Sterba, M, Geng, W, Digby, S, Southern, D, Reddy, H, Hulse, S, Campbell, A, Garton, M, Watkins, C, Smuts, S, Quinn, A, Simpson, B, McMillan, C, Finch, C, Hill, C, Cooper, J, Budd, J, Small, C, O’Leary, R, Collins, E, Holland, A, Alexander, P, Felton, T, Ferguson, S, Sellers, K, Ward, L, Yates, D, Birkinshaw, I, Kell, K, Scott, Z, Pearson, H, Hashmi, M, Hassan, N, Panjwani, A, Umrani, Z, Shaikh, M, Ain, Q, Kanwal, D, Van Bree, S, Bouw-Ruiter, M, Osinga, M, Van Zanten, A, McEldrew, R, Rashan, S, Singh, V, Azergui, N, Bari, S, Beltran, M, Brugman, C, Groeneveld, E, Jafarzadeh, M, Keijzer-Timmers, N, Kester, E, Koelink, M, Kwakkenbos-Craanen, M, Okundaye, C, Parker, L, Peters, S, Post, S, Rietveld, I, Scheepstra-Beukers, I, Schreuder, G, Smit, A, Brillinger, N, Markgraf, R, Eichinger, F, Doran, P, Anjum, A, Best-Lane, J, Barton, F, Miller, L, Richards-Belle, A, Saull, M, Sprinckmoller, S, Wiley, D, Darnell, R, Au, C, Lindstrum, K, Cheng, A, Forbes, A, Heritier, S, Trapani, T, Cuthbertson, B, Manoharan, V, Dondrop, A, Tolppa, T, Ehrmann, S, Hullegie, S, Povoa, P, Beasley, R, Daneman, N, McGloughlin, S, Paterson, D, Venkatesh, B, De Jong, M, Uyeki, T, Baillie, K, Netea, M, Orr, K, Patanwala, A, Tong, S, Cooper, N, Galea, J, Leavis, H, Ogungbenro, K, Patawala, A, Rademaker, E, Youngstein, T, Carrier, M, Fergusson, D, Hunt, B, Kumar, A, Laffan, M, Lother, S, Middeldorp, S, Stanworth, S, De Man, A, Masse, M-H, Abraham, J, Arnold, D, Begin, P, Charlewood, R, Chasse, M, Coyne, M, Daly, J, Gosbell, I, Harvala-Simmonds, H, MacLennan, S, McDyer, J, Menon, D, Pridee, N, Roberts, D, Thomas, H, Tinmouth, A, Triulzi, D, Walsh, T, Wood, E, Calfee, C, O’Kane, C, Shyamsundar, M, Sinha, P, Thompson, T, Young, I, Burrell, A, Ferguson, N, Hodgson, C, Orford, N, Phua, J, Baron, R, Epelman, S, Frankfurter, C, Gommans, F, Kim, E, Leaf, D, Vaduganathan, M, Van Kimmenade, R, Sanil, A, Van Beurden, M, Effelaar, E, Schotsman, J, Boyd, C, Harland, C, Shearer, A, Wren, J, Attanayaka, U, Darshana, S, Ishani, P, Udayanga, I, Higgins, AM, Berry, LR, Lorenzi, E, Murthy, S, McQuilten, Z, Mouncey, PR, Al-Beidh, F, Annane, D, Arabi, YM, Beane, A, Van Bentum-Puijk, W, Bhimani, Z, Bonten, MJM, Bradbury, CA, Brunkhorst, FM, Buzgau, A, Buxton, M, Charles, WN, Cove, M, Detry, MA, Estcourt, LJ, Fagbodun, EO, Fitzgerald, M, Girard, TD, Goligher, EC, Goossens, H, Haniffa, R, Hills, T, Horvat, CM, Huang, DT, Ichihara, N, Lamontagne, F, Marshall, JC, McAuley, DF, McGlothlin, A, McGuinness, SP, McVerry, BJ, Neal, MD, Nichol, AD, Parke, RL, Parker, JC, Parry-Billings, K, Peters, SEC, Reyes, LF, Rowan, KM, Saito, H, Santos, MS, Saunders, CT, Serpa-Neto, A, Seymour, CW, Shankar-Hari, M, Stronach, LM, Turgeon, AF, Turner, AM, Van de Veerdonk, FL, Zarychanski, R, Green, C, Lewis, RJ, Angus, DC, McArthur, CJ, Berry, S, Derde, LPG, Gordon, AC, Webb, SA, Lawler, PR, Comm REMAP-CAP Investigators, Apollo - University of Cambridge Repository, Intensive Care Medicine, Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital Raymond Poincaré [Garches], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Pittsburgh Foundation, PF, Amgen, Health Research Board, HRB: CTN 2014-012, Horizon 2020 Framework Programme, H2020: 101003589, Translational Breast Cancer Research Consortium, TBCRC, Canadian Institutes of Health Research, IRSC: 158584, Heart and Stroke Foundation of Canada, HSF, National Institute for Health and Care Research, NIHR, European Commission, EC, National Health and Medical Research Council, NHMRC: 1101719, APP194811, CS-2016-16-011, GNT2008447, RP-2015-06-18, Office of Health and Medical Research, OHMR, Health Research Council of New Zealand, HRC: 16/631, Eisai, Ministère des Affaires Sociales et de la Santé: PHRC-20-0147, Université Pierre et Marie Curie, UPMC, NIHR Imperial Biomedical Research Centre, BRC, Minderoo Foundation, Funding/Support : The Platform for European Preparedness Against (Re-) emerging Epidemics (PREPARE) consortium by the European Union, FP7-HEALTH-2013-INNOVATION-1 (#602525), the Rapid European COVID-19 Emergency Research response (RECOVER) consortium by the European Union’s Horizon 2020 research and innovation programme (#101003589), the Australian National Health and Medical Research Council (#APP1101719), the Australian Medical Research Future Fund (#APP2002132), the Health Research Council of New Zealand (#16/631), the Canadian Institutes of Health Research Strategy for Patient-Oriented Research Innovative Clinical Trials Program Grant (#158584) and the Canadian Institute of Health Research COVID-19 Rapid Research Funding (#447335), the UK National Institute for Health Research (NIHR) and the NIHR Imperial Biomedical Research Centre, the Health Research Board of Ireland (CTN 2014-012), the UPMC Learning While Doing Program, the Translational Breast Cancer Research Consortium, the French Ministry of Health (PHRC-20-0147), the Wellcome Trust Innovations Project (215522), the Minderoo Foundation, the EU Programme Emergency Support Instrument, the NHS Blood and Transplant Research and Development Programme, the Translational Breast Cancer Research Consortium, the NSW Office of Health and Medical Research, Amgen, Eisai, and the Pittsburgh Foundation. Dr Higgins is funded by an NHMRC Emerging Leadership Fellowship (GNT2008447). Dr McQuilten is funded by an NHMRC Emerging Leadership Fellowship (APP194811). Dr Gordon is funded by an NIHR Research Professorship (RP-2015-06-18) and Dr Shankar-Hari by an NIHR Clinician Scientist Fellowship (CS-2016-16-011). Dr Turgeon is the Chairholder of the Canada Research Chair in Critical Care Neurology and Trauma. Dr Lawler is supported by a career award from the Heart and Stroke Foundation of Canada., and European Project: 602525,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,PREPARE(2014)

Subjects
Adult, Male, corticosteroid, [SDV]Life Sciences [q-bio], Critical Illness, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], antiplatelet, Lopinavir, Adaptive platform trial randomized controlled trial intensive care, pneumonia COVID-19 antiplatelet immunoglobulin antiviral corticosteroid immune modulation anticoagulation, All institutes and research themes of the Radboud University Medical Center, Adrenal Cortex Hormones, Humans, anticoagulation, intensive care, pneumonia, COVID-19 Serotherapy, Original Investigation, Medicine(all), immune modulation, Ritonavir, SARS-CoV-2, COVID-19, Anticoagulants, Bayes Theorem, General Medicine, Middle Aged, antiviral, Receptors, Interleukin-6, Adaptive platform trial, randomized controlled trial, Female, Human medicine, immunoglobulin, Follow-Up Studies, Hydroxychloroquine
Abstract

ImportanceThe longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown.ObjectiveTo determine the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes.Design, Setting, and ParticipantsPrespecified secondary analysis of an ongoing adaptive platform trial (REMAP-CAP) testing interventions within multiple therapeutic domains in which 4869 critically ill adult patients with COVID-19 were enrolled between March 9, 2020, and June 22, 2021, from 197 sites in 14 countries. The final 180-day follow-up was completed on March 2, 2022.InterventionsPatients were randomized to receive 1 or more interventions within 6 treatment domains: immune modulators (n = 2274), convalescent plasma (n = 2011), antiplatelet therapy (n = 1557), anticoagulation (n = 1033), antivirals (n = 726), and corticosteroids (n = 401).Main Outcomes and MeasuresThe main outcome was survival through day 180, analyzed using a bayesian piecewise exponential model. A hazard ratio (HR) less than 1 represented improved survival (superiority), while an HR greater than 1 represented worsened survival (harm); futility was represented by a relative improvement less than 20% in outcome, shown by an HR greater than 0.83.ResultsAmong 4869 randomized patients (mean age, 59.3 years; 1537 [32.1%] women), 4107 (84.3%) had known vital status and 2590 (63.1%) were alive at day 180. IL-6 receptor antagonists had a greater than 99.9% probability of improving 6-month survival (adjusted HR, 0.74 [95% credible interval {CrI}, 0.61-0.90]) and antiplatelet agents had a 95% probability of improving 6-month survival (adjusted HR, 0.85 [95% CrI, 0.71-1.03]) compared with the control, while the probability of trial-defined statistical futility (HR >0.83) was high for therapeutic anticoagulation (99.9%; HR, 1.13 [95% CrI, 0.93-1.42]), convalescent plasma (99.2%; HR, 0.99 [95% CrI, 0.86-1.14]), and lopinavir-ritonavir (96.6%; HR, 1.06 [95% CrI, 0.82-1.38]) and the probabilities of harm from hydroxychloroquine (96.9%; HR, 1.51 [95% CrI, 0.98-2.29]) and the combination of lopinavir-ritonavir and hydroxychloroquine (96.8%; HR, 1.61 [95% CrI, 0.97-2.67]) were high. The corticosteroid domain was stopped early prior to reaching a predefined statistical trigger; there was a 57.1% to 61.6% probability of improving 6-month survival across varying hydrocortisone dosing strategies.Conclusions and RelevanceAmong critically ill patients with COVID-19 randomized to receive 1 or more therapeutic interventions, treatment with an IL-6 receptor antagonist had a greater than 99.9% probability of improved 180-day mortality compared with patients randomized to the control, and treatment with an antiplatelet had a 95.0% probability of improved 180-day mortality compared with patients randomized to the control. Overall, when considered with previously reported short-term results, the findings indicate that initial in-hospital treatment effects were consistent for most therapies through 6 months.

Published
2023

34. Lasersysteme

Author

Albrecht, H., Rohde, E., Zgoda, F., Muller, G., and Kramme, Rüdiger, editor

Published
2007
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38. Erratum: Search for photons with energies above 1018 eV using the hybrid detector of the Pierre Auger Observatory (Journal of Cosmology and Astroparticle Physics (2017) 4 (9) DOI: 10.1088/1475-7516/2017/04/009)

Author

Aab A., Abreu P., Aglietta M., Al Samarai I., Albuquerque I. F. M., Allekotte I., Almela A., Alvarez Castillo J., Alvarez-Muniz J., Anastasi G. A., Anchordoqui L., Andrada B., Andringa S., Aramo C., Arqueros F., Arsene N., Asorey H., Assis P., Aublin J., Avila G., Badescu A. M., Balaceanu A., Barreira Luz R. J., Beatty J. J., Becker K. H., Bellido J. A., Berat C., Bertaina M. E., Bertou X., Biermann P. L., Billoir P., Biteau J., Blaess S. G., Blanco A., Blazek J., Bleve C., Bohacova M., Boncioli D., Bonifazi C., Borodai N., Botti A. M., Brack J., Brancus I., Bretz T., Bridgeman A., Briechle F. L., Buchholz P., Bueno A., Buitink S., Buscemi M., Caballero-Mora K. S., Caccianiga L., Cancio A., Canfora F., Caramete L., Caruso R., Castellina A., Cataldi G., Cazon L., Chavez A. G., Chinellato J. A., Chudoba J., Clay R. W., Colalillo R., Coleman A., Collica L., Coluccia M. R., Conceicao R., Contreras F., Cooper M. J., Coutu S., Covault C. E., Cronin J., D'Amico S., Daniel B., Dasso S., Daumiller K., Dawson B. R., de Almeida R. M., de Jong S. J., de Mauro G., de Mello Neto J. R. T., de Mitri I., de Oliveira J., de Souza V., Debatin J., Deligny O., Di Giulio C., Di Matteo A., Diaz Castro M. L., Diogo F., Dobrigkeit C., D'Olivo J. C., Dorosti Q., dos Anjos R. C., Dova M. T., Dundovic A., Ebr J., Engel R., Erdmann M., Erfani M., Escobar C. O., Espadanal J., Etchegoyen A., Falcke H., Farrar G., Fauth A. C., Fazzini N., Fick B., Figueira J. M., Filipcic A., Fratu O., Freire M. M., Fujii T., Fuster A., Gaior R., Garcia B., Garcia-Pinto D., Gate F., Gemmeke H., Gherghel-Lascu A., Ghia P. L., Giaccari U., Giammarchi M., Giller M., Glas D., Glaser C., Golup G., Gomez Berisso M., Gomez Vitale P. F., Gonzalez N., Gorgi A., Gorham P., Grillo A. F., Grubb T. D., Guarino F., Guedes G. P., Hampel M. R., Hansen P., Harari D., Harrison T. A., Harton J. L., Haungs A., Hebbeker T., Heck D., Heimann P., Herve A. E., Hill G. C., Hojvat C., Holt E., Homola P., Horandel J. R., Horvath P., Hrabovsky M., Huege T., Hulsman J., Insolia A., Isar P. G., Jandt I., Jansen S., Johnsen J. A., Josebachuili M., Kaapa A., Kambeitz O., Kampert K. H., Katkov I., Keilhauer B., Kemp E., Kemp J., Kieckhafer R. M., Klages H. O., Kleifges M., Kleinfeller J., Krause R., Krohm N., Kuempel D., Kukec Mezek G., Kunka N., Kuotb Awad A., LaHurd D., Lauscher M., Legumina R., Leigui de Oliveira M. A., Letessier-Selvon A., Lhenry-Yvon I., Link K., Lopes L., Lopez R., Lopez Casado A., Luce Q., Lucero A., Malacari M., Mallamaci M., Mandat D., Mantsch P., Mariazzi A. G., Maris I. C., Marsella G., Martello D., Martinez H., Martinez Bravo O., Masias Meza J. J., Mathes H. J., Mathys S., Matthews J., Matthews J. A. J., Matthiae G., Mayotte E., Mazur P. O., Medina C., Medina-Tanco G., Melo D., Menshikov A., Micheletti M. I., Middendorf L., Minaya I. A., Miramonti L., Mitrica B., Mockler D., Mollerach S., Montanet F., Morello C., Mostafa M., Muller A. L., Muller G., Muller M. A., Muller S., Mussa R., Naranjo I., Nellen L., Nguyen P. H., Niculescu-Oglinzanu M., Niechciol M., Niemietz L., Niggemann T., Nitz D., Nosek D., Novotny V., Nozka H., Nunez L. A., Ochilo L., Oikonomou F., Olinto A., Palatka M., Pallotta J., Papenbreer P., Parente G., Parra A., Paul T., Pech M., Pedreira F., Pekala J., Pelayo R., Pena-Rodriguez J., Pereira L. A. S., Perlin M., Perrone L., Peters C., Petrera S., Phuntsok J., Piegaia R., Pierog T., Pieroni P., Pimenta M., Pirronello V., Platino M., Plum M., Porowski C., Prado R. R., Privitera P., Prouza M., Quel E. J., Querchfeld S., Quinn S., Ramos-Pollan R., Rautenberg J., Ravignani D., Revenu B., Ridky J., Risse M., Ristori P., Rizi V., Rodrigues de Carvalho W., Rodriguez Fernandez G., Rodriguez Rojo J., Rogozin D., Roncoroni M. J., Roth M., Roulet E., Rovero A. C., Ruehl P., Saffi S. J., Saftoiu A., Salamida F., Salazar H., Saleh A., Salesa Greus F., Salina G., Sanchez F., Sanchez-Lucas P., Santos E. M., Santos E., Sarazin F., Sarmento R., Sarmiento C. A., Sato R., Schauer M., Scherini V., Schieler H., Schimp M., Schmidt D., Scholten O., Schovanek P., Schroder F. G., Schulz A., Schulz J., Schumacher J., Sciutto S. J., Segreto A., Settimo M., Shadkam A., Shellard R. C., Sigl G., Silli G., Sima O., Smialkowski A., Smida R., Snow G. R., Sommers P., Sonntag S., Sorokin J., Squartini R., Stanca D., Stanic S., Stasielak J., Stassi P., Strafella F., Suarez F., Suarez Duran M., Sudholz T., Suomijarvi T., Supanitsky A. D., Swain J., Szadkowski Z., Taboada A., Taborda O. A., Tapia A., Theodoro V. M., Timmermans C., Todero Peixoto C. J., Tomankova L., Tome B., Torralba Elipe G., Travnicek P., Trini M., Ulrich R., Unger M., Urban M., Valdes Galicia J. F., Valino I., Valore L., van Aar G., van Bodegom P., van den Berg A. M., van Vliet A., Varela E., Vargas Cardenas B., Varner G., Vazquez J. R., Vazquez R. A., Veberic D., Vergara Quispe I. D., Verzi V., Vicha J., Villasenor L., Vorobiov S., Wahlberg H., Wainberg O., Walz D., Watson A. A., Weber M., Weindl A., Wiencke L., Wilczynski H., Winchen T., Wirtz M., Wittkowski D., Wundheiler B., Yang L., Yelos D., Yushkov A., Zas E., Zavrtanik D., Zavrtanik M., Zepeda A., Zimmermann B., Ziolkowski M., Zong Z., Zuccarello F., Aab, A., Abreu, P., Aglietta, M., Al Samarai, I., Albuquerque, I. F. M., Allekotte, I., Almela, A., Alvarez Castillo, J., Alvarez-Muniz, J., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Arqueros, F., Arsene, N., Asorey, H., Assis, P., Aublin, J., Avila, G., Badescu, A. M., Balaceanu, A., Barreira Luz, R. J., Beatty, J. J., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Biermann, P. L., Billoir, P., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Bohacova, M., Boncioli, D., Bonifazi, C., Borodai, N., Botti, A. M., Brack, J., Brancus, I., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, L., Cancio, A., Canfora, F., Caramete, L., Caruso, R., Castellina, A., Cataldi, G., Cazon, L., Chavez, A. G., Chinellato, J. A., Chudoba, J., Clay, R. W., Colalillo, R., Coleman, A., Collica, L., Coluccia, M. R., Conceicao, R., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Cronin, J., D'Amico, S., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., de Jong, S. J., de Mauro, G., de Mello Neto, J. R. T., de Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., Deligny, O., Di Giulio, C., Di Matteo, A., Diaz Castro, M. L., Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorosti, Q., dos Anjos, R. C., Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Erfani, M., Escobar, C. O., Espadanal, J., Etchegoyen, A., Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Fick, B., Figueira, J. M., Filipcic, A., Fratu, O., Freire, M. M., Fujii, T., Fuster, A., Gaior, R., Garcia, B., Garcia-Pinto, D., Gate, F., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Glas, D., Glaser, C., Golup, G., Gomez Berisso, M., Gomez Vitale, P. F., Gonzalez, N., Gorgi, A., Gorham, P., Grillo, A. F., Grubb, T. D., Guarino, F., Guedes, G. P., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harton, J. L., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Herve, A. E., Hill, G. C., Hojvat, C., Holt, E., Homola, P., Horandel, J. R., Horvath, P., Hrabovsky, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Jansen, S., Johnsen, J. A., Josebachuili, M., Kaapa, A., Kambeitz, O., Kampert, K. H., Katkov, I., Keilhauer, B., Kemp, E., Kemp, J., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Krohm, N., Kuempel, D., Kukec Mezek, G., Kunka, N., Kuotb Awad, A., Lahurd, D., Lauscher, M., Legumina, R., Leigui de Oliveira, M. A., Letessier-Selvon, A., Lhenry-Yvon, I., Link, K., Lopes, L., Lopez, R., Lopez Casado, A., Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mandat, D., Mantsch, P., Mariazzi, A. G., Maris, I. C., Marsella, G., Martello, D., Martinez, H., Martinez Bravo, O., Masias Meza, J. J., Mathes, H. J., Mathys, S., Matthews, J., Matthews, J. A. J., Matthiae, G., Mayotte, E., Mazur, P. O., Medina, C., Medina-Tanco, G., Melo, D., Menshikov, A., Micheletti, M. I., Middendorf, L., Minaya, I. A., Miramonti, L., Mitrica, B., Mockler, D., Mollerach, S., Montanet, F., Morello, C., Mostafa, M., Muller, A. L., Muller, G., Muller, M. A., Muller, S., Mussa, R., Naranjo, I., Nellen, L., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Niemietz, L., Niggemann, T., Nitz, D., Nosek, D., Novotny, V., Nozka, H., Nunez, L. A., Ochilo, L., Oikonomou, F., Olinto, A., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Paul, T., Pech, M., Pedreira, F., Pekala, J., Pelayo, R., Pena-Rodriguez, J., Pereira, L. A. S., Perlin, M., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Plum, M., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Quinn, S., Ramos-Pollan, R., Rautenberg, J., Ravignani, D., Revenu, B., Ridky, J., Risse, M., Ristori, P., Rizi, V., Rodrigues de Carvalho, W., Rodriguez Fernandez, G., Rodriguez Rojo, J., Rogozin, D., Roncoroni, M. J., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saffi, S. J., Saftoiu, A., Salamida, F., Salazar, H., Saleh, A., Salesa Greus, F., Salina, G., Sanchez, F., Sanchez-Lucas, P., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento, C. A., Sato, R., Schauer, M., Scherini, V., Schieler, H., Schimp, M., Schmidt, D., Scholten, O., Schovanek, P., Schroder, F. G., Schulz, A., Schulz, J., Schumacher, J., Sciutto, S. J., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Smialkowski, A., Smida, R., Snow, G. R., Sommers, P., Sonntag, S., Sorokin, J., Squartini, R., Stanca, D., Stanic, S., Stasielak, J., Stassi, P., Strafella, F., Suarez, F., Suarez Duran, M., Sudholz, T., Suomijarvi, T., Supanitsky, A. D., Swain, J., Szadkowski, Z., Taboada, A., Taborda, O. A., Tapia, A., Theodoro, V. M., Timmermans, C., Todero Peixoto, C. J., Tomankova, L., Tome, B., Torralba Elipe, G., Travnicek, P., Trini, M., Ulrich, R., Unger, M., Urban, M., Valdes Galicia, J. F., Valino, I., Valore, L., van Aar, G., van Bodegom, P., van den Berg, A. M., van Vliet, A., Varela, E., Vargas Cardenas, B., Varner, G., Vazquez, J. R., Vazquez, R. A., Veberic, D., Vergara Quispe, I. D., Verzi, V., Vicha, J., Villasenor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Walz, D., Watson, A. A., Weber, M., Weindl, A., Wiencke, L., Wilczynski, H., Winchen, T., Wirtz, M., Wittkowski, D., Wundheiler, B., Yang, L., Yelos, D., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., Zuccarello, F., Aab A., Abreu P., Aglietta M., Al Samarai I., Albuquerque I.F.M., Allekotte I., Almela A., Alvarez Castillo J., Alvarez-Muniz J., Anastasi G.A., Anchordoqui L., Andrada B., Andringa S., Aramo C., Arqueros F., Arsene N., Asorey H., Assis P., Aublin J., Avila G., Badescu A.M., Balaceanu A., Barreira Luz R.J., Beatty J.J., Becker K.H., Bellido J.A., Berat C., Bertaina M.E., Bertou X., Biermann P.L., Billoir P., Biteau J., Blaess S.G., Blanco A., Blazek J., Bleve C., Bohacova M., Boncioli D., Bonifazi C., Borodai N., Botti A.M., Brack J., Brancus I., Bretz T., Bridgeman A., Briechle F.L., Buchholz P., Bueno A., Buitink S., Buscemi M., Caballero-Mora K.S., Caccianiga L., Cancio A., Canfora F., Caramete L., Caruso R., Castellina A., Cataldi G., Cazon L., Chavez A.G., Chinellato J.A., Chudoba J., Clay R.W., Colalillo R., Coleman A., Collica L., Coluccia M.R., Conceicao R., Contreras F., Cooper M.J., Coutu S., Covault C.E., Cronin J., D'Amico S., Daniel B., Dasso S., Daumiller K., Dawson B.R., de Almeida R.M., de Jong S.J., de Mauro G., de Mello Neto J.R.T., de Mitri I., de Oliveira J., de Souza V., Debatin J., Deligny O., Di Giulio C., Di Matteo A., Diaz Castro M.L., Diogo F., Dobrigkeit C., D'Olivo J.C., Dorosti Q., dos Anjos R.C., Dova M.T., Dundovic A., Ebr J., Engel R., Erdmann M., Erfani M., Escobar C.O., Espadanal J., Etchegoyen A., Falcke H., Farrar G., Fauth A.C., Fazzini N., Fick B., Figueira J.M., Filipcic A., Fratu O., Freire M.M., Fujii T., Fuster A., Gaior R., Garcia B., Garcia-Pinto D., Gate F., Gemmeke H., Gherghel-Lascu A., Ghia P.L., Giaccari U., Giammarchi M., Giller M., Glas D., Glaser C., Golup G., Gomez Berisso M., Gomez Vitale P.F., Gonzalez N., Gorgi A., Gorham P., Grillo A.F., Grubb T.D., Guarino F., Guedes G.P., Hampel M.R., Hansen P., Harari D., Harrison T.A., Harton J.L., Haungs A., Hebbeker T., Heck D., Heimann P., Herve A.E., Hill G.C., Hojvat C., Holt E., Homola P., Horandel J.R., Horvath P., Hrabovsky M., Huege T., Hulsman J., Insolia A., Isar P.G., Jandt I., Jansen S., Johnsen J.A., Josebachuili M., Kaapa A., Kambeitz O., Kampert K.H., Katkov I., Keilhauer B., Kemp E., Kemp J., Kieckhafer R.M., Klages H.O., Kleifges M., Kleinfeller J., Krause R., Krohm N., Kuempel D., Kukec Mezek G., Kunka N., Kuotb Awad A., LaHurd D., Lauscher M., Legumina R., Leigui de Oliveira M.A., Letessier-Selvon A., Lhenry-Yvon I., Link K., Lopes L., Lopez R., Lopez Casado A., Luce Q., Lucero A., Malacari M., Mallamaci M., Mandat D., Mantsch P., Mariazzi A.G., Maris I.C., Marsella G., Martello D., Martinez H., Martinez Bravo O., Masias Meza J.J., Mathes H.J., Mathys S., Matthews J., Matthews J.A.J., Matthiae G., Mayotte E., Mazur P.O., Medina C., Medina-Tanco G., Melo D., Menshikov A., Micheletti M.I., Middendorf L., Minaya I.A., Miramonti L., Mitrica B., Mockler D., Mollerach S., Montanet F., Morello C., Mostafa M., Muller A.L., Muller G., Muller M.A., Muller S., Mussa R., Naranjo I., Nellen L., Nguyen P.H., Niculescu-Oglinzanu M., Niechciol M., Niemietz L., Niggemann T., Nitz D., Nosek D., Novotny V., Nozka H., Nunez L.A., Ochilo L., Oikonomou F., Olinto A., Palatka M., Pallotta J., Papenbreer P., Parente G., Parra A., Paul T., Pech M., Pedreira F., Pekala J., Pelayo R., Pena-Rodriguez J., Pereira L.A.S., Perlin M., Perrone L., Peters C., Petrera S., Phuntsok J., Piegaia R., Pierog T., Pieroni P., Pimenta M., Pirronello V., Platino M., Plum M., Porowski C., Prado R.R., Privitera P., Prouza M., Quel E.J., Querchfeld S., Quinn S., Ramos-Pollan R., Rautenberg J., Ravignani D., Revenu B., Ridky J., Risse M., Ristori P., Rizi V., Rodrigues de Carvalho W., Rodriguez Fernandez G., Rodriguez Rojo J., Rogozin D., Roncoroni M.J., Roth M., Roulet E., Rovero A.C., Ruehl P., Saffi S.J., Saftoiu A., Salamida F., Salazar H., Saleh A., Salesa Greus F., Salina G., Sanchez F., Sanchez-Lucas P., Santos E.M., Santos E., Sarazin F., Sarmento R., Sarmiento C.A., Sato R., Schauer M., Scherini V., Schieler H., Schimp M., Schmidt D., Scholten O., Schovanek P., Schroder F.G., Schulz A., Schulz J., Schumacher J., Sciutto S.J., Segreto A., Settimo M., Shadkam A., Shellard R.C., Sigl G., Silli G., Sima O., Smialkowski A., Smida R., Snow G.R., Sommers P., Sonntag S., Sorokin J., Squartini R., Stanca D., Stanic S., Stasielak J., Stassi P., Strafella F., Suarez F., Suarez Duran M., Sudholz T., Suomijarvi T., Supanitsky A.D., Swain J., Szadkowski Z., Taboada A., Taborda O.A., Tapia A., Theodoro V.M., Timmermans C., Todero Peixoto C.J., Tomankova L., Tome B., Torralba Elipe G., Travnicek P., Trini M., Ulrich R., Unger M., Urban M., Valdes Galicia J.F., Valino I., Valore L., van Aar G., van Bodegom P., van den Berg A.M., van Vliet A., Varela E., Vargas Cardenas B., Varner G., Vazquez J.R., Vazquez R.A., Veberic D., Vergara Quispe I.D., Verzi V., Vicha J., Villasenor L., Vorobiov S., Wahlberg H., Wainberg O., Walz D., Watson A.A., Weber M., Weindl A., Wiencke L., Wilczynski H., Winchen T., Wirtz M., Wittkowski D., Wundheiler B., Yang L., Yelos D., Yushkov A., Zas E., Zavrtanik D., Zavrtanik M., Zepeda A., Zimmermann B., Ziolkowski M., Zong Z., and Zuccarello F.

Subjects
erratum, UHE Cosmic Rays
Abstract

1 Exposure calculation Due to a mistake in the numerical integration following eq. (6.2) of the original article [1], the exposure shown in figure 5 of the original article was incorrect. The correct exposure is shown in figure 1. 2 Upper limits on the integral photon flux and fraction The incorrect exposure affects the calculation of the upper limits on the integral photon flux following eq. (6.1) of the original article. The correct values for the upper limits are 0.038, 0.010, 0.009, 0.008 and 0.007 km−2 sr−1 yr−1 for threshold energies of 1, 2, 3, 5 and 10 EeV. The correct values for the upper limits on the integral photon fraction subsequently derived are 0.14 %, 0.17 %, 0.42 %, 0.86 % and 2.9 % for the same threshold energies. 3 Author list The author list of this erratum also corrects a mistake made in the original article, where F. Zuccarello was missing and Z. Zong was listed twice.

Published
2020

39. Additional file 5 of Ischemic injury of the upper gastrointestinal tract after out-of-hospital cardiac arrest: a prospective, multicenter study

Author

Grimaldi, D., Legriel, S., Pichon, N., Colardelle, P., Leblanc, S., Canou��-Poitrine, F., Ben Hadj Salem, O., Muller, G., de Prost, N., Herrmann, S., Marque, S., Baron, A., Sauneuf, B., Messika, J., Dior, M., Creteur, J., Bedos, J. P., Boutin, E., and Cariou, A.

Subjects
nervous system, health services administration, health care facilities, manpower, and services, macromolecular substances, respiratory tract diseases
Abstract

Additional file 5. Evolution of SOFA score according to severity of gastrointestinal ischemic lesions.

Published
2022
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40. Additional file 2 of Ischemic injury of the upper gastrointestinal tract after out-of-hospital cardiac arrest: a prospective, multicenter study

Author

Grimaldi, D., Legriel, S., Pichon, N., Colardelle, P., Leblanc, S., Canou��-Poitrine, F., Ben Hadj Salem, O., Muller, G., de Prost, N., Herrmann, S., Marque, S., Baron, A., Sauneuf, B., Messika, J., Dior, M., Creteur, J., Bedos, J. P., Boutin, E., and Cariou, A.

Abstract

Additional file 2. Therapeutic advices after gastroscopy.

Published
2022
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41. Additional file 3 of Ischemic injury of the upper gastrointestinal tract after out-of-hospital cardiac arrest: a prospective, multicenter study

Author

Grimaldi, D., Legriel, S., Pichon, N., Colardelle, P., Leblanc, S., Canou��-Poitrine, F., Salem, O. Ben Hadj, Muller, G., de Prost, N., Herrmann, S., Marque, S., Baron, A., Sauneuf, B., Messika, J., Dior, M., Creteur, J., Bedos, J. P., Boutin, E., and Cariou, A.

Subjects
nervous system, musculoskeletal, neural, and ocular physiology, macromolecular substances
Abstract

Additional file 3. Presence and severity of ischemic lesions according to inclusion centres.

Published
2022
Full Text
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42. Additional file 4 of Ischemic injury of the upper gastrointestinal tract after out-of-hospital cardiac arrest: a prospective, multicenter study

Author

Grimaldi, D., Legriel, S., Pichon, N., Colardelle, P., Leblanc, S., Canou��-Poitrine, F., Salem, O. Ben Hadj, Muller, G., de Prost, N., Herrmann, S., Marque, S., Baron, A., Sauneuf, B., Messika, J., Dior, M., Creteur, J., Bedos, J. P., Boutin, E., and Cariou, A.

Subjects
health services administration, health care facilities, manpower, and services, sense organs, skin and connective tissue diseases, respiratory tract diseases
Abstract

Additional file 4. Changes in SOFA score at specific time points during the ICU stay in the different group.

Published
2022
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43. Additional file 1 of Ischemic injury of the upper gastrointestinal tract after out-of-hospital cardiac arrest: a prospective, multicenter study

Author

Grimaldi, D., Legriel, S., Pichon, N., Colardelle, P., Leblanc, S., Canou��-Poitrine, F., Ben Hadj Salem, O., Muller, G., de Prost, N., Herrmann, S., Marque, S., Baron, A., Sauneuf, B., Messika, J., Dior, M., Creteur, J., Bedos, J. P., Boutin, E., and Cariou, A.

Abstract

Additional file 1. Examples of ischemic lesions.

Published
2022
Full Text
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46. Design and Stability of a Floating Free Stream Energy Converter

Author

Batten, W MJ, Weichbrodt, F, Muller, G U, Hadler, J, Semlow, C, Hochbaum, M, Dimke, S, Frohle, P, and Proceedings of the 34th World Congress of the International Association for Hydro-Environment Research and Engineering: 33rd Hydrology and Water Resources Symposium and 10th Conference on Hydraulics in Water Engineering

Published
2011

48. Dapagliflozin and cardiovascular outcomes in type 2 diabetes

Author

Wiviott, S, Raz, I, Bonaca, M, Mosenzon, O, Kato, E, Cahn, A, Silverman, M, Zelniker, T, Kuder, J, Murphy, S, Bhatt, D, Leiter, L, Mcguire, D, Wilding, J, Ruff, C, Nilsson, G, Fredriksson, M, Johansson, P, Langkilde, A, Sabatine, M, Bansilal, S, Furtado, R, Fish, M, Gabovitch, D, Jevne, A, Ahern, S, Im, K, Goodrich, E, Lowe, C, Fisher, N, Gannon, J, Trindade, S, Towarowski, A, Fox, Y, Johnsson, E, Ranft, S, Faber, B, Wallander, M, Weiss, A, Buskila, A, Abola, M, Ardissino, D, Averkov, O, Aylward, P, Bode, C, Bonnici, F, Bonora, E, Budaj, A, Cernea, S, Chiang, C, Cooper, M, Dalby, A, Deerochanawong, C, Dellborg, M, Diaz, R, Dimulescu, D, Eliaschewitz, F, Goudev, A, Hadjadj, S, Herrera, M, Huo, Y, Jermendy, G, Ji, L, Kadowaki, T, Kiss, R, Kooy, A, Kumar, K, Lewis, B, Litwak, L, Lopez-Sendon, J, Ma, R, Merlini, P, Nauck, M, Nguyen, T, Nicolau, J, Ostgren, C, Ophuis, T, Padilla, F, Pais, P, Park, K, Parkhomenko, A, Ray, K, Rosenstock, J, Ruda, M, Satman, I, Shestakova, M, Smahelova, A, Spinar, J, Strojek, K, Sy, R, Tankova, T, Theroux, P, Tkac, I, Van Gaal, L, Wainstein, J, Harrington, R, Droller, M, Lee, K, Nesto, R, Tuomilehto, J, Hedlin, H, Desai, M, Sayfer, I, Alexanian, S, Awtry, E, Bentley-Lewis, R, Berger, C, Croce, K, Desai, A, Garg, R, Gelfand, E, Gignac, G, Goessling, W, Ho, C, Hochberg, E, Lane, A, Larrey, D, Leeman, D, Lewis, J, Link, M, Mcdonnell, M, Norden, A, Pande, A, Rosenberg, C, Rost, N, Ruberg, F, Schiff, E, Silverman, S, Singhal, A, Wagner, A, Wolpin, B, Aizenberg, D, Fernandez, M, Sala, J, Maffei, L, Luquez, C, Waitman, J, Rista, L, Nardone, L, Sposetti, G, Cantero, M, Alvarisqueta, A, Montana, O, Cuadrado, J, Cartasegna, L, Baccaro, C, Chertkoff, A, Sanabria, H, Vainstein, N, Amerena, J, Arya, K, D'Emden, M, Proietto, J, Moses, R, Colquhoun, D, Stranks, S, Lehman, R, Hamilton, A, Whelan, A, Simpson, R, Purnell, P, Abhayaratna, W, Hammett, C, Mckeirnan, M, Sullivan, D, Bach, L, Hughes, K, Mathieu, C, Vercammen, C, Scheen, A, Duyck, F, Cools, F, 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J., Angueira-Serrano E., Lillestol M., Hanlon B., Soufer J., Garcia B., Iteld B., Venugopal C., Ahmed A., Duardo-Guerra Y., Jetty P., Miranda A., Wahlen J., Lederman S., Cohen K., Lake L., French W. J., Tahirkheli N., Baker S., Stoltz R., Wilson J., Nadar V., Brown J., Larrain G., Wiseman A., Ruoff G., Williams M., Tan A., Hartman I., Singh N., Graf R., Wakefield P., McNeill R., Byars W., Reyes Almodovar R., Jones S., Kantaros L., Hegedosh N., Graves M., Bernstein M., Falkowski S., Bialow M., Paraschos A., Dagher G., Arif A., Condit J., Chaykin L., Grunstra B., Earl J., Unks D., Srivastava S., Benson M., Huffman C., Miller G., Willis J., Bender K., Martin E., Blackmore R., Rohr K., Chilka S., Gadowski G., Fitz-Patrick D., Benjamin S., Morin D., Zias Dilena A., Acosta R., Claassen D., Miranda F., Raad G., Inzerello A., Porter J., Bhattacharya A., Gutmann J., Korpas D., Syed M., Zieve F., Raisinghani A., Alam S., Bartkowiak A., Boccalandro F., Talano J., Mercado A., Krichmar P., Oldfield C., Adams K., Gorman T., Lewis D., Shah R., Shockey G., Lefebvre G., Andrawis N., Tami L., Bittar N., Khan M. S., Rink L., Hendrix E., Wood J., Robinson J., Pavon H., Irfan M., Gonzalez E., Singal R., Shore K., Saba F., Bianco J., Erickson B., Gorson D., Puri S., Arauz-Pacheco C., Forman S., Akyea-Djamson A., Lieber I., Barker B., Desai P., Sotolongo C., Steinhoff J., Hill R., Radin M., Patel R., Lieberman S., Wenocur H., Dagogo-Jack S., Lupovitch S., Ison R., Bacharach J. M., Diogo J., Mazzella M., Greenwald J., Quadrel M., Mayer N., Datu J., McCartney M., Bruce T., Singal D., Turner J., Videau B., Fritz R., Fox D., Calatayud G., Sheldon W., Kereiakes D., Thomas J., Salacata A., McCullum K., Harris B., de Souza J., Rahman A., Blumenthal S., Narayan P., Bloch M., Augenbraun C., Bernstein R., Perlman R., Berman J., LaBryer L., Wynne A., Fish J., Zarich S., Gabra N., Popeil L., Hermany P., Barreto A., Pomposini D., Gonzalez-Campoy J. M., Langer M., Bayron C., Suneja R., Kamlet J., Wheeler K., Hurley S., Sharma S., Wefald F., Hershon K., O'Connor T., Pueblitz G., Laguerre J., Amin M., Alfonso T., Jaffrani N., Isserman S., Portnay E., Vlastaris A., Dy J., Hagan M., Noveck H., Kraft P., Andersen J., Foley B., Carr K., Gelormini J., Williams T., Landau C., Richwine R., Thakkar M., Karim A., Madhun Z., Francyk D., Lamantia J., Baker B., Zhang W., Lev V., Hasan M., Captain A., Herzog W., Friedman K., Lawson W., Desai V., Ow C., Simons R., Mandviwala M., Le T., Hack T., Zebrack J., Henderson D., DeJulia J., Mehta R., Reza S., Poonawala R., Awad A., Velasquez M., Mohiuddin S., Salazar Sharma M., Myrick G., Gottlieb D., Ovalle F., Alfieri A., Ahmed S., Bohula E., Donahoe S. M., Longshaw K., Eshaghian S., Lash J., Goldberg R. K., Fox B., Mostel E., Dobies D., Ward H., Burbano J., Puleo P., Lenhard M. J., Korn D., Thadani U., Bradley A., Kmetzo J., Heasley E., Raikhel M., Mahr N., Bittar G., Fuentes F., Raghu P., Diep T. T. B., Tran Q. 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I, Shestakova, M, Smahelova, A, Spinar, J, Strojek, K, Sy, R, Tankova, T, Theroux, P, Tkac, I, Van Gaal, L, Wainstein, J, Harrington, R, Droller, M, Lee, K, Nesto, R, Tuomilehto, J, Hedlin, H, Desai, M, Sayfer, I, Alexanian, S, Awtry, E, Bentley-Lewis, R, Berger, C, Croce, K, Desai, A, Garg, R, Gelfand, E, Gignac, G, Goessling, W, Ho, C, Hochberg, E, Lane, A, Larrey, D, Leeman, D, Lewis, J, Link, M, Mcdonnell, M, Norden, A, Pande, A, Rosenberg, C, Rost, N, Ruberg, F, Schiff, E, Silverman, S, Singhal, A, Wagner, A, Wolpin, B, Aizenberg, D, Fernandez, M, Sala, J, Maffei, L, Luquez, C, Waitman, J, Rista, L, Nardone, L, Sposetti, G, Cantero, M, Alvarisqueta, A, Montana, O, Cuadrado, J, Cartasegna, L, Baccaro, C, Chertkoff, A, Sanabria, H, Vainstein, N, Amerena, J, Arya, K, D'Emden, M, Proietto, J, Moses, R, Colquhoun, D, Stranks, S, Lehman, R, Hamilton, A, Whelan, A, Simpson, R, Purnell, P, Abhayaratna, W, Hammett, C, Mckeirnan, M, Sullivan, D, Bach, L, Hughes, K, Mathieu, C, Vercammen, C, 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J., Muirhead N., Zimmermann R., Galiwango P., Tobe S., Priestman B., Zinman B., Ma J., Zhao X., Wang C., Zhang A., Dong Y., Dong X., Luo M., Guo J., Zheng Z., Li Y., Liang Y., Peng D., Maderic D., Spinarova L., Raclavska L., Ludka O., Rihacek I., Karasova J., Pelikanova M., Vlasakova H., Urbancova K., Zamrazil V., Hradec J., Vlasicova H., Racicka E., Okenka L., Naplava R., Skopecek J., Palova S., Krystl T., Pistek Z., Oznerova M., Andresova A., Sarbochova R., Taborska P., Petrova I., Stanek L., Reichert P., Lorenc Z., Szabo M., Petit C., Krempf M., Boye A., Dubois S., Clavel S., Gourdy P., Elbaz M., Jazayeri S., Gouet D., Verges B., Couffinhal T., Sendeski M., Klausmann G., Appel K., Pein M., Thieme R., Schumm-Draeger P., Jacob S., Toursarkissian N., Kleinecke-Pohl U., Tschope D., Ott P., Haak T., Nauck M., Derwahl K., Bugger H., Hui G., Tsang C., Zilahi Z., Puski L., Vangel S., Fulop T., Pall K., Hidvegi T., Revesz K., Koranyi L., Kajetan M., Kerenyi Z., Penzes J., Herczeg B., 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B., Tran Q. K., Tran N., Nguyen D., and Nguyen V.

Abstract

BACKGROUND The cardiovascular safety profile of dapagliflozin, a selective inhibitor of sodium-glucose cotransporter 2 that promotes glucosuria in patients with type 2 diabetes, is undefined. METHODS We randomly assigned patients with type 2 diabetes who had or were at risk for atherosclerotic cardiovascular disease to receive either dapagliflozin or placebo. The primary safety outcome was a composite of major adverse cardiovascular events (MACE), defined as cardiovascular death, myocardial infarction, or ischemic stroke. The primary efficacy outcomes were MACE and a composite of cardiovascular death or hospitalization for heart failure. Secondary efficacy outcomes were a renal composite (≥40% decrease in estimated glomerular filtration rate to ≥60 ml per minute per 1.73 m2 of body-surface area, new end-stage renal disease, or death from renal or cardiovascular causes) and death from any cause. RESULTS We evaluated 17,160 patients, including 10,186 without atherosclerotic cardiovascular disease, who were followed for a median of 4.2 years. In the primary safety outcome analysis, dapagliflozin met the prespecified criterion for noninferiority to placebo with respect to MACE (upper boundary of the 95% confidence interval [CI], ≥1.3; P≥0.001 for noninferiority). In the two primary efficacy analyses, dapagliflozin did not result in a lower rate of MACE (8.8% in the dapagliflozin group and 9.4% in the placebo group; hazard ratio, 0.93; 95% CI, 0.84 to 1.03; P = 0.17) but did result in a lower rate of cardiovascular death or hospitalization for heart failure (4.9% vs. 5.8%; hazard ratio, 0.83; 95% CI, 0.73 to 0.95; P = 0.005), which reflected a lower rate of hospitalization for heart failure (hazard ratio, 0.73; 95% CI, 0.61 to 0.88); there was no between-group difference in cardiovascular death (hazard ratio, 0.98; 95% CI, 0.82 to 1.17). A renal event occurred in 4.3% in the dapagliflozin group and in 5.6% in the placebo group (hazard ratio, 0.76; 95% CI, 0.67 to 0.87)

Published
2019

49. Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial

Author

Bhatt, D, Steg, P, Mehta, S, Leiter, L, Simon, T, Fox, K, Held, C, Andersson, M, Himmelmann, A, Ridderstrale, W, Chen, J, Song, Y, Diaz, R, Goto, S, James, S, Ray, K, Parkhomenko, A, Kosiborod, M, Mcguire, D, Harrington, R, Santos, V, Jain, A, Lendel, I, Russo, M, Haught, W, Bouza, M, Gogia, H, Banerjee, S, Kichura, G, Kantaros, L, Padron, F, Passi, R, Stone, J, Pursley, M, D'Urso, M, Gardner, T, Bennett, J, Nour, K, Saini, S, Zhang, W, Kumbhani, D, Thomas, D, Angiolillo, D, Bertolet, B, Roman-Miranda, A, Black, R, Manshadi, R, Vaca, C, Blanco, A, Napoli, M, Brabham, D, Akyea-Djamson, A, Desai, P, Prasada, S, Khaira, A, Forgosh, L, Lieber, I, Umpierrez, G, Singal, D, Londono, J, Fraser, N, Ruiz, J, Vega, D, Rodriguez, L, Brown, C, Syed, F, Aggarwala, G, Eaves, W, Foster, M, Gupta, D, Avino, D, Asfour, W, Tonnessen, G, Zhao, X, Singh, N, Brockmyre, A, Lepor, N, Shammas, N, Blick, D, Hearne, S, Prodafikas, J, Carell, E, Izzo, M, Karim, A, Zakhary, B, Atieh, M, Leichter, S, Meadows, C, Hotchkiss, D, Abu-Fadel, M, Wiseman, A, Bander, J, Shah, M, Ganim, R, Sopko, K, Khan, M, Lloret, R, Weirick, T, Mehta, R, Thadani, U, Bhargava, A, Moya, J, Staniloae, C, Guerra, Y, Chhabra, A, Kosmicki, D, Shaheen, W, Mohammed, A, Bitters, J, Pattanayak, J, Javier, J, Srivastava, S, Phillips, R, Al-Amin, J, Lillestol, M, Simpson, P, Hazan, L, Amin, A, Shah, G, Korpas, D, Platt, B, Dickert, J, Puente, O, Hiotis, L, Doyle, T, Rajan, R, Meholick, A, Gring, C, Hage-Korban, E, Feldman, R, Colfer, H, Butman, S, Hart, T, Huling, R, Eshaghian, S, Quintana, O, Cheung, D, Handel, F, Rodriguez, M, Suh, D, Gordon, P, Pressman, G, Bauer, M, French, W, Barettella, M, Chatrathi, S, Suresh, D, Goldberg, R, Huth, M, Younis, L, Rahman, A, Mascolo, R, Welch, M, Suneja, R, Smith, S, Shurmur, S, Agaiby, J, Jingo, A, Johnston, J, Beth, M, Vlastaris, A, Kemp, S, Taheri, H, Pereira, E, Deyoung, M, Hawa, Z, Smith, R, Galski, T, Garas, S, Reddy, M, Sharma, S, Hargrove, J, Treasure, C, Emerson, R, Haddad, T, 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C., Istratoaie O., Coman I., Militaru C., Cinteza M., Sinnaeve P. R., Nicolau J. C., Kerr Saraiva J. F., Widimsky P., Kristensen S. D., Hartikainen J., Darius H., Tse H. F., Pais P., Lev E., de Luca L., Ramos Lopez G. A., Kontny F., Babilonia N. A., Zateyshchikov D. A., Ruda M., Elamin O., Kovar F., Dalby A. J., Bueno H., Chiang C. -E., Parkhomenko A., Nguyen T. Q., and Leonsson-Zachrisson M.

Abstract

Background: Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor. Methods: The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population). Findings: Between Feb 17, 2014, and May 24, 2016, 11 154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3·3 years (IQR 2·8–3·8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7·3%] of 5558 vs 480 [8·6%] of 5596; HR 0·85 [95% CI 0·74–0·97], p=0·013). The same effect was not observed in patients without PCI (p=0·76, pinteraction=0·16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3·1%] with ticagrelor vs 183 (3·3%) with placebo

Published
2019

50. Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial

Author

Ray, K, Colhoun, H, Szarek, M, Baccara-Dinet, M, Bhatt, D, Bittner, V, Budaj, A, Diaz, R, Goodman, S, Hanotin, C, Harrington, R, Jukema, J, Loizeau, V, Lopes, R, Moryusef, A, Murin, J, Pordy, R, Ristic, A, Roe, M, Tunon, J, White, H, Zeiher, A, Schwartz, G, Steg, P, Tricoci, P, Mahaffey, K, Edelberg, J, Lecorps, G, Sasiela, W, Tamby, J, Aylward, P, Drexel, H, Sinnaeve, P, Dilic, M, Gotcheva, N, Prieto, J, Yong, H, Lopez-Jaramillo, P, Pecin, I, Reiner, Z, Ostadal, P, Viigimaa, M, Nieminen, M, Chumburidze, V, Marx, N, Danchin, N, Liberopoulos, E, Montenegro Valdovinos, P, Tse, H, Kiss, R, Xavier, D, Zahger, D, Valgimigli, M, Kimura, T, Kim, H, Kim, S, Erglis, A, Laucevicius, A, Kedev, S, Yusoff, K, Ramos Lopez, G, Alings, M, Halvorsen, S, Correa Flores, R, Morais, J, Dorobantu, M, Karpov, Y, Chua, T, Fras, Z, Dalby, A, de Silva, H, Hagstrom, E, Landmesser, U, Chiang, C, Sritara, P, Guneri, S, Parkhomenko, A, Moriarty, P, Vogel, R, Chaitman, B, Kelsey, S, Olsson, A, Rouleau, J, Simoons, 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M., Schmalfuss C., Picone M., Pederson R., Herzog W., Friedman K., Lindsey J., Nowins R., Timothy E., Leonard P., Lepor N., El Shahawy M., Weintraub H., Irimpen A., Alonso A., May W., Christopher D., Galski T., Chu A., Mody F., Ramin E., Hodes Z., Rossi J., Rose G., Fairlamb J., Lambert C., Raisinghani A., Abbate A., Vetrovec G., King M., Carey C., Gerber J., Younis L., Park H. T., Vidovich M., Knutson T., Friedman D., Chaleff F., Loussararian A., Rozeman P., Kimmelstiel C., Kuvin J., Silver K., Foster M., Tonnessen G., Espinoza A., Amlani M., Wali A., Malozzi C., Jong G. T., Massey C., Wattanakit K., O'Donnell P. J., Singal D., Jaffrani N., Banuru S., Fisher D., Xenakis M., Perlmutter N., Bhagwat R., Strader J., Blonder R., Akyea-Djamson A., Labroo A., Marais H. J., Claxton E., Weiss R., Kathryn R., Berk M., Rossi P., Joshi P., Khera A., Khaira A. S., Kumkumian G., Lupovitch S., Purow J., Welka S., Hoffman D., Fischer S., Soroka E., Eagerton D., Pancholy S., Ray M., Erenrich N., Farrar M., Pollock S., French W. J., Diamantis S., Guy D., Gimple L., Neustel M., Schwartz S., Pereira E., Albert S., Spriggs D., Strain J., Mittal S., Vo A., Chane M., Hall J., Vijay N., Lotun K., Lester F. M., Nahhas A., Pope T., Nager P., Vohra R., Sharma M., Bashir R., Ahmed H., Berlowitz M., Fishberg R., Barrucco R., Yang E., Radin M., Sporn D., Stapleton D., Eisenberg S., Landzberg J., Mcgough M., Turk S., Schwartz M., Sundram P. S., Jain D., Zainea M., Bayron C., Karlsberg R., Dohad S., Lui H., Keen W., Westerhausen D., Khurana S., Agarwal H., Birchem J., Penny W., Chang M., Murphy S., Henry J., Schifferdecker B., Gilbert J. M., Chalavarya G., Eaton C., Schmedtje J. F., Christenson S., Dotani I., Denham D., Macdonell A., Gibson P., Rahman A., Al Joundi T., Assi N., Conrad G., Kotha P., Love M., Giesler G., Rubenstein H., Gamil D., Akright L., Krawczyk J., Cobler J., Wells T., Welker J., Foster R., Gilmore R., Anderson J., Jacoby D., Gardner G., Dandillaya R., Vora K., Kostis J., Hunter J., Laxson D., Ball E., Lopes R., Egydio F., Kawakami A., Oliveira J., Wozniak J., Matthews A., Ratky C., Valiris J., Berdan L., Hepditch A., Quintero K., Rorick T., Westbrook M., Pascual A., Rovito C., Bezault M., Drouet E., Simon T., Alsweiler C., Luyten A., Butters J., Griffith L., Shaw M., Grunberg L., Islam S., Bregeault M. -F., Bougon N., Faustino D., Fontecave S., Murphy J., Verrier M., Agnetti V., Andersen D., Badreddine E., Bekkouche M., Bouancheau C., Brigui I., Brocklehurst M., Cianciarulo J., Devaul D., Domokos S., Gache C., Gobillot C., Guillou S., Healy J., Heath M., Jaiwal G., Javierre C., Labeirie J., Monier M., Morales U., Mrabti A., Mthombeni B., Okan B., Smith L., Sheller J., Sopena S., Pellan V., Benbernou F., Bengrait N., Lamoureux M., Kralova K., Scemama M., Bejuit R., Coulange A., Berthou C., Repincay J., Lorenzato C., Etienne A., Gouet V., Normand M., Ourliac A., Rondel C., Adamo A., Beltran P., Barraud P., Dubois-Gache H., Halle B., Metwally L., Mourgues M., Sotty M., Vincendet M., Cotruta R., Chengyue Z., Fournie-Lloret D., Morrello C., Perthuis A., Picault P., Zobouyan I., Dempsey M. A., McClanahan M. 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A., and McClanahan M. A.

Abstract

Background: After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1·4–1·8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue in a prespecified analysis of the ODYSSEY OUTCOMES trial of the PCSK9 inhibitor alirocumab, assessing its effects on cardiovascular outcomes by baseline glycaemic status, while also assessing its effects on glycaemic measures including risk of new-onset diabetes. Methods: ODYSSEY OUTCOMES was a randomised, double-blind, placebo-controlled trial, done at 1315 sites in 57 countries, that compared alirocumab with placebo in patients who had been admitted to hospital with an acute coronary syndrome (myocardial infarction or unstable angina) 1–12 months before randomisation and who had raised concentrations of atherogenic lipoproteins despite use of high-intensity statins. Patients were randomly assigned (1:1) to receive alirocumab or placebo every 2 weeks; randomisation was stratified by country and was done centrally with an interactive voice-response or web-response system. Alirocumab was titrated to target LDL cholesterol concentrations of 0·65–1·30 mmol/L. In this prespecified analysis, we investigated the effect of alirocumab on cardiovascular events by glycaemic status at baseline (diabetes, prediabetes, or normoglycaemia)—defined on the basis of patient history, review of medical records, or baseline HbA1c or fasting serum glucose—and risk of new-onset diabetes among those without diabetes at baseline. The primary endpoint was a composite of death from coronary heart disease, non-fatal myocardial infarction, fatal or non-fatal ischaemic stroke, or unstable angina requiring

Published
2019

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