189 results on '"Muller, Alexandra"'
Search Results
2. Sporadic nonfunctional pancreatic neuroendocrine tumors: Risk of lymph node metastases and aggressiveness according to tumor size: A multicenter international study
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Perinel, Julie, Nappo, Gennaro, Zerbi, Alessandro, Heidsma, Charlotte M., Nieveen van Dijkum, Elisabeth J.M., Han, Ho Seong, Yoon, Yoo-Seok, Satoi, Sohei, Demir, Ihsan Ekin, Friess, Helmut, Vashist, Yogesh, Izbicki, Jakob, Muller, Alexandra Charlotte, Gloor, Beat, Sandini, Marta, Gianotti, Luca, Subtil, Fabien, and Adham, Mustapha
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- 2022
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3. Epidemiology of Human Parechovirus Type 3 Upsurge in 2 Hospitals, Freiburg, Germany, 2018
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Elling, Roland, du Bottcher, Sindy, Bois, Florian, Muller, Alexandra, Prifert, Christiane, Weissbrich, Benedikt, Hofmann, Jorg, Korn, Klaus, Eis-Hubinger, Anna-Maria, Hufnagel, Markus, and Panning, Marcus
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Hospitals -- Analysis -- Health aspects ,Viral proteins -- Analysis -- Health aspects ,Epidemics -- Analysis -- Health aspects ,Infection -- Analysis -- Health aspects ,Epidemiology -- Analysis -- Health aspects ,Health - Abstract
Most human parechovirus (HPeV) infections cause mild upper respiratory tract symptoms or unspecific febrile illnesses. Severe clinical manifestations, such as meningitis/ encephalitis, myocarditis, and newborn sepsis, are caused by HPeV [...]
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- 2019
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4. G-quadruplex ligands as potent regulators of lysosomes
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Ferret, Lucille, primary, Alvarez-Valadez, Karla, additional, Rivière, Jennifer, additional, Muller, Alexandra, additional, Bohálová, Natalia, additional, Yu, Luo, additional, Guittat, Lionel, additional, Brázda, Vaclav, additional, Kroemer, Guido, additional, Mergny, Jean-Louis, additional, and Djavaheri-Mergny, Mojgan, additional
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- 2023
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5. Economic value of regional spearfishing competitions
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Schilling, Hayden T., primary, Riley, Indiana J., additional, Puckeridge, Aaron C., additional, Milne-Muller, Alexandra, additional, and Callaghan, Corey T., additional
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- 2022
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6. Inhibition of amyloid-β plaque formation by α-synuclein
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Bachhuber, Teresa, Katzmarski, Natalie, McCarter, Joanna F., Loreth, Desiree, Tahirovic, Sabina, Kamp, Frits, Abou-Ajram, Claudia, Nuscher, Brigitte, Serrano-Pozo, Alberto, Muller, Alexandra, Prinz, Marco, Steiner, Harald, Hyman, Bradley T., Haass, Christian, and Meyer-Luehmann, Melanie
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Development and progression -- Genetic aspects -- Research ,Biological sciences ,Health - Abstract
Amyloid-β (Aβ) plaques and α-synuclein (α-syn)-rich Lewy bodies are the major neuropathological hallmarks of Alzheimer's disease (AD) and Parkinson's disease, respectively. An overlap of pathologies is found in most individuals with dementia with Lewy bodies (DLB) (1) and in more than 50% of AD cases (2). Their brains display substantial α-syn accumulation not only in Lewy bodies, but also in dystrophic neurites decorating Aβ plaques (2-4). Several studies report binding and coaggregation of Aβ and α-syn (5-7), yet the precise role of α-syn in amyloid plaque formation remains elusive. Here we performed intracerebral injections of α-syn-containing preparations into amyloid precursor protein (APP) transgenic mice (expressing [APP695.sup.KM670/671NL] and [PSEN1.sup.L166P] under the control of the neuron-specific Thy-1 promoter; referred to here as 'APPPS1'). Unexpectedly, α-syn failed to cross-seed Aβ plaques in vivo, but rather it inhibited plaque formation in APPPS1 mice coexpressing [SNCA.sup.A30P] (referred to here as 'APPPS1 x [A30P]aSYN' double-transgenic mice). This was accompanied by increased Ap levels in cerebrospinal fluid despite unchanged overall Aβ levels. Notably, the seeding activity of Aβ-containing brain homogenates was considerably reduced by α-syn, and Aβ deposition was suppressed in grafted tissue from [A30P]aSYN transgenic mice. Thus, we conclude that an interaction between Aβ and α-syn leads to inhibition of Aβ deposition and to reduced plaque formation., The initial discovery of α-syn within plaques as the precursor of the non-amyloid component (NAC) (8) and the binding of Aβ and α-syn in vitro and in situ (5,6) suggested [...]
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- 2015
7. Wondering About Wobbling
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Muller, Alexandra, primary, Connolly, Tarah, additional, Galisky, John, additional, Skinner, Ron, additional, Christman, Devon M., additional, and Harlow, Danielle, additional
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- 2022
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8. Preschool Children's Problem-Solving Interactions at Computers and Jigsaw Puzzles.
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Muller, Alexandra A. and Perlmutter, Marion
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In two studies, preschool children's social interactions while working on problem-solving tasks were investigated. In the first study, 27 preschool children were observed over a period of 9 weeks while working on learning games at a computer. Sharing, verbal and nonverbal instruction, and initiation of interaction were recorded. A total of 63 percent of the time at the computer was spent with a peer, and peers often spontaneously shared and instructed each other. Age-related increases in time spent at the computer, as well as in self-initiation of interaction and sharing, were evident. No differences were found in boys' and girls' activities at the computer. In the second study, 18 children were observed over a period of 5 weeks while working with jigsaw puzzles. In this context, children worked with peers just 7 percent of the time and exhibited far fewer instances of cooperative interaction. Generally, results indicated that preschool children can engage in cooperative problem solving and instruction and that various activities differentially stimulate such behavior. Further, in contrast to stereotypes about computers, this research suggested that even children younger than school age can work effectively at computers and that computer technology may actually stimulate social interaction in problem solving. (Author/RH)
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- 1984
9. La Grèce et les Balkans : une géographie perdue et retrouvée
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PETRAKOS, Georges and Muller, Alexandra
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- 1999
10. Les échanges de biens industriels entre la Bulgarie et l'Union européenne (1990-1995)
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MINTCHEV, Vesselin and Muller, Alexandra
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- 1999
11. A Rhodobacter capsulatus member of a universal permease family imports molybdate and other oxyanions
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Gisin, Jonathan, Muller, Alexandra, Pfander, Yvonne, Leimkuhler, Silke, Narberhaus, Franz, and Masepohl, Bernd
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Bacteria, Photosynthetic -- Physiological aspects ,Bacteria, Photosynthetic -- Genetic aspects ,Molybdenum -- Physiological aspects ,Biological sciences - Abstract
Molybdenum (Mo) is an important trace element that is toxic at high concentrations. To resolve the mechanisms underlying Mo toxicity, Rhodobacter capsulatus mutants tolerant to high Mo concentrations were isolated by random transposon Tn5 mutagenesis. The insertion sites of six independent isolates mapped within the same gene predicted to code for a permease of unknown function located in the cytoplasmic membrane. During growth under Mo-replete conditions, the wild-type strain accumulated considerably more Mo than the permease mutant. For mutants defective for the permease, the high-affinity molybdate importer ModABC, or both transporters, in vivo Mo-dependent nitrogenase (Mo-nitrogenase) activities at different Mo concentrations suggested that ModABC and the permease import molybdate in nanomolar and micromolar ranges, respectively. Like the permease mutants, a mutant defective for ATP sulfurylase tolerated high Mo concentrations, suggesting that ATP sulfurylase is the main target of Mo inhibition in R. capsulatus. Sulfate-dependent growth of a double mutant defective for the permease and the high-affinity sulfate importer CysTWA was reduced compared to those of the single mutants, implying that the permease plays an important role in sulfate uptake. In addition, permease mutants tolerated higher tungstate and vanadate concentrations than the wild type, suggesting that the permease acts as a general oxyanion importer. We propose to call this permease PerO (for oxyanion permease). It is the first reported bacterial molybdate transporter outside the ABC transporter family. doi: 10.1128/JB.00742-10
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- 2010
12. Specific interactions between four molybdenum-binding proteins contribute to Mo-dependent gene regulation in Rhodobacter capsulatus
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Wiethaus, Jessica, Muller, Alexandra, Neumann, Meina, Neumann, Sandra, Leimkuhler, Silke, Narberhaus, Franz, and Masepohl, Bernd
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Bacteria, Photosynthetic -- Genetic aspects ,Bacteria, Photosynthetic -- Physiological aspects ,Protein binding -- Research ,Bacterial proteins -- Properties ,Biological sciences - Abstract
The phototrophic purple bacterium Rhodobacter capsulatus encodes two transcriptional regulators, MopA and MopB, with partially overlapping and specific functions in molybdate-dependent gene regulation. Both MopA and MopB consist of an N-terminal DNA-binding helix-turn-helix domain and a C-terminal molybdate-binding di-MOP domain. They formed homodimers as apo-proteins and in the molybdate-bound state as shown by yeast two-hybrid (Y2H) studies, glutaraldehyde cross-linking, gel filtration chromatography, and copurification experiments. Y2H studies suggested that both the DNA-binding and the molybdate-binding domains contribute to dimer formation. Analysis of molybdate binding to MopA and MopB revealed a binding stoichiometry of four molybdate oxyanions per homodimer. Specific interaction partners of MopA and MopB were the molybdate transporter ATPase ModC and the molbindin-like Mop protein, respectively. Like other molbindins, the R. capsulatus Mop protein formed hexamers, which were stabilized by binding of six molybdate oxyanions per hexamer. Heteromer formation of MopA and MopB was shown by Y2H studies and copurification experiments. Reporter gene activity of a strictly MopA-dependent mop-lacZ fusion in mutant strains defective for either mopA, mopB, or both suggested that MopB negatively modulates expression of the mop promoter. We propose that depletion of the active MopA homodimer pool by formation of MopA-MopB heteromers might represent a fine-tuning mechanism controlling mop gene expression.
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- 2009
13. Triarylpyridine Compounds and Chloroquine Act in Concert to Trigger Lysosomal Membrane Permeabilization and Cell Death in Cancer Cells
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Beauvarlet, Jennifer, Das, Rabindra, Alvarez-Valadez, Karla, Martins, Isabelle, Muller, Alexandra, Darbo, Elodie, Richard, Elodie, Soubeyran, Pierre, Kroemer, Guido, Guillon, Jean, Mergny, Jean-Louis, Djavaheri-Mergny, Mojgan, Actions for OnCogenesis understanding and Target Identification in ONcology (ACTION), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bordeaux Segalen - Bordeaux 2-Institut Bergonié [Bordeaux], UNICANCER-UNICANCER, Acides Nucléiques : Régulations Naturelle et Artificielle (ARNA), Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Institut Gustave Roussy (IGR), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Karolinska University Hospital [Stockholm], Chinese Academy of Sciences [Suzhou], Mergny, Jean-Louis, Institut Bergonié [Bordeaux], UNICANCER-UNICANCER-Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité)
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[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology ,[SDV.BC]Life Sciences [q-bio]/Cellular Biology ,[SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,lcsh:RC254-282 ,Lysosome ,Article ,cell death ,resistance to therapy ,cancer ,lysosomal membrane permeabilization ,G-quadruplex ligand ,[SDV.BC] Life Sciences [q-bio]/Cellular Biology ,triarylpyridine compounds - Abstract
International audience; Lysosomes play a key role in regulating cell death in response to cancer therapies, yet little is known on the possible role of lysosomes in the therapeutic efficacy of G-quadruplex DNA ligands (G4L) in cancer cells. Here, we investigate the relationship between the modulation of lysosomal membrane damage and the degree to which cancer cells respond to the cytotoxic effects of G-quadruplex ligands belonging to the triarylpyridine family. Our results reveal that the lead compound of this family, 20A promotes the enlargement of the lysosome compartment as well as the induction of lysosome-relevant mRNAs. Interestingly, the combination of 20A and chloroquine (an inhibitor of lysosomal functions) led to a significant induction of lysosomal membrane permeabilization coupled to massive cell death. Similar effects were observed when chloroquine was added to three new triarylpyridine derivatives. Our findings thus uncover the lysosomal effects of triarylpyridines compounds and delineate a rationale for combining these compounds with chloroquine to increase their anticancer effects.
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- 2020
14. Primate sociality in evolutionary context
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Muller, Alexandra E. and Soligo, Christophe
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Physical anthropology -- Research ,Hominids -- Research ,Anthropology/archeology/folklore - Abstract
Much work has been done to further our understanding of the mechanisms that underlie the diversity of primate social organizations, but none has addressed the limits to that diversity or the question of what causes species to either form or not form social networks. The fact that all living primates typically live in social networks makes it highly likely that the last common ancestor of living primates already lived in social networks, and that sociality formed an integral part of the adaptive nature of primate origins. A characterization of primate sociality within the wider mammalian context is therefore essential to further our understanding of the adaptive nature of primate origins. Here we determine correlates of sociality and nonsociality in rodents as a model to infer causes of sociality in primates. We found sociality to be most strongly associated with large-bodied arboreal species that include a significant portion of fruit in their diet. Fruits and other plant products, such as flowers, seeds, and young leaves, are patchily distributed in time and space and are therefore difficult to find. These food resources are, however, predictable and dependable when their location is known. Hence, membership in a social unit can maximize food exploitation if information on feeding sites is shared. Whether sociality evolved in the primate stem lineage or whether it was already present earlier in the evolution of Euarchontoglires remains uncertain, although tentative evidence points to the former scenario. In either case, frugivory is likely to have played an important role in maintaining the presence of a social lifestyle throughout primate evolution. KEY WORDS primate origins; rodents; social organization; social networks; frugivory
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- 2005
15. Finding solid ground: law enforcement, key populations and their health and rights in South Africa
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Scheibe, Andrew, Howell, Simon, Muller, Alexandra, Katumba, Munyaradzi, Langen, Bram, Artz, Lillian, and Marks, Monique
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Medical ethics -- Analysis ,Transgender people -- Protection and preservation -- Health aspects ,HIV infections -- Care and treatment -- Prevention ,Sex oriented businesses -- Protection and preservation -- Health aspects ,Discrimination against gays -- Social aspects ,Law enforcement -- Analysis ,Health - Abstract
Introduction: Sex workers, people who use drugs, men who have sex with men, women who have sex with women and transgender people in South Africa frequently experience high levels of stigma, abuse and discrimination. Evidence suggests that such abuse is sometimes committed by police officers, meaning that those charged with protection are perpetrators. This reinforces cycles of violence, increases the risk of HIV infection, undermines HIV prevention and treatment interventions and violates the constitutional prescriptions that the police are mandated to protect. This paper explores how relationship building can create positive outcomes while taking into account the challenges associated with reforming police strategies in relation to key populations, and vice versa. Discussion: We argue that relationships between law enforcement agencies and key populations need to be re-examined and reconstituted to enable appropriate responses and services. The antagonistic positioning, 'othering' and blame assignment frequently seen in interactions between law enforcement officials and key populations can negatively influence both, albeit for different reasons. In addressing these concerns, we argue that mediation based on consensual dialogue is required, and can be harnessed through a process that highlights points of familiarity that are often shared, but not understood, by both parties. Rather than laying blame, we argue that substantive changes need to be owned and executed by all role-players, informed by a common language that is cognisant of differing perspectives. Conclusions: Relational approaches can be used to identify programmes that align goals that are part of law enforcement, human rights and public health despite not always being seen as such. Law enforcement champions and representatives of key populations need to be identified and supported to promote interventions that are mutually reinforcing, and address perceived differences by highlighting commonality. Creating opportunities to share experiences in mediation can be beneficial to all role-players. While training is important, it is not a primary mechanism to change behaviour and attitudes. Keywords: law enforcement; HIV; key populations; relationships; policing; South Africa., Introduction The nature of relationships and hierarchies between institutions and social groupings in society affects health and wellbeing in complex ways. For those who are already marginalized, such social dynamics [...]
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- 2016
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16. Synthesizing and standardizing criteria for the evaluation of sustainability indicators in the water sector
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Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria, Universitat Politècnica de Catalunya. SUMMLab - Sustainability Measurement and Modeling Lab, Pires Carneiro, Álex, Morató Farreras, Jordi, Peixoto, H, Bradley, S., Muller, Alexandra, Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria, Universitat Politècnica de Catalunya. SUMMLab - Sustainability Measurement and Modeling Lab, Pires Carneiro, Álex, Morató Farreras, Jordi, Peixoto, H, Bradley, S., and Muller, Alexandra
- Abstract
This is a pre-print of an article published in Environment, Development and Sustainability. The final authenticated version is available online at: https://doi.org/10.1007/s10668-019-00508-z, Indicators are one of the tools available in planning and management projects that aid in the decision-making process and the monitoring of those decisions on the path to sustainable use and management of water and natural resources. However, the quality and trustworthiness of the indicators depend on the constant improvement in the means to assess and design criteria sets. The identification of criteria to evaluate indicators and its subsequence selection are not an ordinary task. The research identified a proliferation of unconsolidated criteria in use in the sustainability and water resource management domains. In response, a process of synthesis and consolidation was undertaken in order to reduce the level of redundancies and to identify possible candidates for “core criteria” that are identified as being a relevant part of most evaluation frameworks. A representative collection of sources from the specialized literature was screened for evaluation criteria. Altogether, 74 sources were assessed, comprising 346 mentions of criteria applied for indicator assessment. A detailed synthesis was performed to organize the criteria and identify possible redundancies. The analysis allowed a reduction from the 346 initial criteria to 60 unique criteria. The study offers a standard title and description for each criterion, contributing to improve clarity and avoid ambiguity. The criteria were also ranked to identify which criteria were in more systemic use. Of the 60 criteria found, the 12 most cited were identified as possible core criteria for framework development. Also, in order to facilitate the design of indicator sets, all 60 criteria were divided into two approaches (scientific/top-down or end-use/bottom-up). This study identified significant redundancies and a lack of standardization in the use of criteria, and it also ranked criteria to facilitate multi-method framework development. Thus, it is essential that indicator designers not only consider criteria that hav, Peer Reviewed, Postprint (author's final draft)
- Published
- 2019
17. UK Is Hotbed for Europe M&A With Currys, Deliveroo Among Targets.
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Muller, Alexandra
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MERGERS & acquisitions ,INVESTORS ,POSTAL service - Abstract
The UK is expected to experience a surge in mergers and acquisitions (M&A) in the second half of the year due to the country's cheap equity market. British companies, including Deliveroo, Currys, and Dowlais Group, are among the most likely M&A targets. The increase in UK deals is driven by low valuations, with the UK stock market trading at a 42% discount to the MSCI World. Political stability under the new Labour government is also expected to support the M&A activity. Foreign bidders have been active in the UK, with recent deals including Carlsberg's acquisition of Britvic and the purchase of various companies by Royal Mail owner International Distribution Services, cybersecurity firm Darktrace, packaging giant DS Smith, and logistics business Wincanton. The recent Labour election victory has brought optimism to the M&A sector, and investors anticipate renewable energy firms to attract buyers under the new government. However, there may be a pause in cross-border deals until the US election in November, and bidders may face pressure to offer more money for high-quality UK companies. [Extracted from the article]
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- 2024
18. Private Equity Deals Dent European IPO Pipeline as Stocks Waver.
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Gopinath, Swetha and Muller, Alexandra
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PRIVATE equity ,GOING public (Securities) ,STOCKS (Finance) - Abstract
Private equity firms are acquiring potential initial public offering (IPO) candidates in Europe, leading to a decrease in the IPO pipeline. Companies such as Flix SE and Sunrise Medical had their listing plans canceled after being bought out by investment firms. Private equity offers are seen as a welcome alternative for firms struggling to raise funds through IPOs. The gap between public and private investors is still significant, with portfolio managers hesitant to pay high prices for new stocks. However, as the IPO market improves, the pendulum may swing back in favor of listings. [Extracted from the article]
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- 2024
19. Foreign Appetite for UK Firms at 2021-High on Cheap Valuations.
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Easton, Joe and Muller, Alexandra
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VALUATION ,BUSINESS enterprises ,PRICE-earnings ratio ,STANDARD & Poor's 500 Index ,INTERNATIONAL trade ,FOREIGN banking industry - Abstract
Foreign appetite for UK firms is on the rise, with the value of proposed, pending, or completed takeovers reaching £32.7 billion ($41.4 billion) so far this year, a 143% increase from 2023. London-listed stocks are particularly attractive due to their lower valuations compared to international peers, likely influenced by the cost-of-living crisis and the aftermath of Brexit. The UK's FTSE 100 index is 12% cheaper than the Euro Stoxx 50 benchmark and 45% cheaper than the US S&P 500. Analysts predict that foreign acquisitions of UK companies will continue until the valuation gap closes or shareholders resist opportunistic takeover offers. [Extracted from the article]
- Published
- 2024
20. Kestrel Sees More UK Takeovers After Big Wins on Software Deals.
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Ren, Henry and Muller, Alexandra
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KESTRELS ,SMALL capitalization stocks - Abstract
Kestrel Partners LLP, an investment firm specializing in small-cap software companies, is set to profit from two UK take-private deals. The firm owns significant stakes in IQGeo Group Plc and Gresham Technologies Plc, both of which have received offers from US private equity firms. Kestrel's strategy is to build minority equity stakes in listed software businesses with a market value of less than £200 million. The firm expects more interest in UK assets and believes the London market is currently favorable for mergers and acquisitions. The Kestrel Opportunities Fund has had a strong performance, with a 12-month annualized return of about 27%. [Extracted from the article]
- Published
- 2024
21. UK Housebuilders in Merger Mode as Election Points to Revival.
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Easton, Joe and Muller, Alexandra
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MERGERS & acquisitions ,ELECTIONS ,POLITICAL parties ,LABOR market ,MORTGAGE rates ,HOUSING market - Abstract
A surge in mergers and acquisitions among UK homebuilders is expected before the upcoming general election, potentially making this year the busiest for deals in over a decade. Bellway's rejected bid for Crest Nicholson is the latest in a series of potential big deals in the sector, including Barratt's acquisition of Redrow and Persimmon's reported interest in Cala Group. The housing market slowdown and the Labour party's plans to build 1.5 million homes have created an opportune time for consolidation. The mergers could provide a much-needed boost to housing shares, which have underperformed in recent years. [Extracted from the article]
- Published
- 2024
22. London Broker Panmure Liberum Cutting Dozens of Jobs After Merger.
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Kehnscherper, Leonard and Muller, Alexandra
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MERGERS & acquisitions ,GOING public (Securities) ,INVESTMENT banking - Abstract
Investment bank Panmure Liberum is expected to cut over two dozen jobs following a merger earlier this year. The cuts are anticipated to be announced this week. The merger between Panmure Gordon and Liberum was an all-stock deal that aimed to address the challenges faced by corporate brokers in the City of London. The merger brought together Panmure Gordon, an established firm founded in 1876, with Liberum, a relative upstart. [Extracted from the article]
- Published
- 2024
23. Modelling beef meat quality traits during ageing by early post-mortem pH decay descriptors
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Xavier, Cristina, Gonzales-Barron, Ursula, Muller, Alexandra, and Cadavez, Vasco
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food and beverages ,Beef meat quality - Abstract
Previous work has demonstrated that beef carcasses can be promptly and accurately classified into optimal quality and cold-shortened in accordance to the concept of pH/temperature ‘ideal window’ by using carcass characteristics and early post-mortem pH/temperature decay descriptors. The objective of this study was to assess the combined effects of the aforementioned variables on the two main eating quality attributes of meat – namely, tenderness (measured as shear force) and juiciness (measured as cooking loss) – during chill ageing. The pH and temperature in longissimus thoracis muscle of 51 beef carcasses were recorded during 24 h post-mortem, and decay descriptors were then obtained by fitting exponential models. Measures of Warner-Bratzler shear force and cooking loss were obtained from cooked meat after 3, 8 and 13 days of cold ageing. The fitted mixed-effect models revealed that both meat tenderisation and cooking loss increased with ageing (P
- Published
- 2018
24. Multilingual Interaction in Plurilingual Classes ? European School Practice
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Muller, Alexandra and Beardsmore, Hugo Baetens
- Abstract
The paper illustrates how interaction operates in classes where there is no single shared common language between teachers and pupils. Samples from a European School primary class taken from 1669 extracts are given of teacher-pupil, pupil-teacher and pupil-pupil interaction. Goals of the programme investigated are to integrate heterogeneous groups while showing respect for language diversity, to encourage co-operation, to accustom pupils to a multilingual environment and to encourage development of multilingual skills. Communication strategies, both verbal and non-verbal, in a typical classroom sub-culture are shown. Results reveal how the strategies used by all involved enable them to cope with the unexpected, which is typical of a linguistically mixed class. Code-switching plays a significant and legitimate role in the coping strategies.
- Published
- 2004
25. Breast cancer-derived exosomes alter macrophage polarization via gp130/STAT3 signaling
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Ham, Sunyoung, Lima, Luize G., Chai, Edna Pei Zhi, Muller, Alexandra, Lobb, Richard J., Krumeich, Sophie, Wen, Shu Wen, Wiegmans, Adrian P., Möller, Andreas, Ham, Sunyoung, Lima, Luize G., Chai, Edna Pei Zhi, Muller, Alexandra, Lobb, Richard J., Krumeich, Sophie, Wen, Shu Wen, Wiegmans, Adrian P., and Möller, Andreas
- Abstract
Tumor-derived exosomes are being recognized as essential mediators of intercellular communication between cancer and immune cells. It is well established that bone marrow-derived macrophages (BMDMs) take up tumor-derived exosomes. However, the functional impact of these exosomes on macrophage phenotypes is controversial and not well studied. Here, we show that breast cancer-derived exosomes alter the phenotype of macrophages through the interleukin-6 (IL-6) receptor beta (glycoprotein 130, gp130)-STAT3 signaling pathway. Addition of breast cancer-derived exosomes to macrophages results in the activation of the IL-6 response pathway, including phosphorylation of the key downstream transcription factor STAT3. Exosomal gp130, which is highly enriched in cancer exosomes, triggers the secretion of IL-6 from BMDMs. Moreover, the exposure of BMDMs to cancer-derived exosomes triggers changes from a conventional toward a polarized phenotype often observed in tumor-associated macrophages. All of these effects can be inhibited through the addition of a gp130 inhibitor to cancer-derived exosomes or by blocking BMDMs exosome uptake. Collectively, this work demonstrates that breast cancer-derived exosomes are capable of inducing IL-6 secretion and a pro-survival phenotype in macrophages, partially via gp130/STAT3 signaling.
- Published
- 2018
26. Origin and evolution of primate social organization: A reconstruction
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Muller, Alexandra E. and Thalmann, Urs
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Primates -- Behavior ,Biological sciences - Abstract
Primate social organization, its origin and evolution, is discussed.
- Published
- 2000
27. Competências e funções do terminólogo: um olhar para o contexto das empresas
- Author
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Muller, Alexandra Feldekircher
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terminólogo, atividade profissional, terminologia, empresa ,Terminología ,Lingüística Aplicada - Abstract
Este trabalho tem por objetivo refletir sobre as competências e funções do profissional da área da Terminologia, o terminólogo, junto às diferentes atividades profissionais. Para tanto, são apresentados apontamentos teóricos sobre Terminologia, bem como uma reflexão sobre as competências desse perfil de profissional e, por fim, suas funções frente às atividades profissionais, especialmente, nas empresas. Salienta-se, assim, que este estudo permite abordar a situação desse profissional que cada vez mais merece um lugar de destaque em atividades que envolvem a comunicação especializada em empresas na era globalizada de intensas relações comerciais nacionais e internacionais em que se vive.
- Published
- 2017
28. Hargreaves Lansdown Offer Brings UK Wealth-Manager M&A in Focus.
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Muller, Alexandra
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MERGERS & acquisitions ,ECONOMIES of scale ,INVESTORS ,ALTERNATIVE investments ,STOCK prices ,INTERNATIONAL financial institutions - Abstract
Hargreaves Lansdown, the largest platform for retail investors in the UK, has rejected a £4.7 billion takeover offer from a group of investors, stating that it undervalues the company. The offer represented a 30% premium at the time, but Hargreaves Lansdown's stock price soared following the rejection. Analysts suggest that this potential deal could have positive implications for other wealth management firms in the UK, such as Quilter, AJ Bell, and St James's Place, as the industry seeks scale and cost savings through mergers and acquisitions. The UK market is currently undervalued compared to other major markets, and UK investment managers are seen as attractive takeover targets due to their low valuations. [Extracted from the article]
- Published
- 2024
29. TSB Sale Would Let BBVA Add Cash to Sabadell Bid, Analysts Say.
- Author
-
Muller, Alexandra
- Subjects
BUYOUTS ,CHIEF executive officers - Abstract
Banco Bilbao Vizcaya Argentaria (BBVA) may be able to increase its hostile takeover bid for Banco de Sabadell by selling Sabadell's UK unit, TSB Banking Group. According to analysts at Barclays, divesting TSB could allow BBVA to include a cash element of up to 10% of the offer without significantly impacting BBVA's shareholders. BBVA's CEO, Onur Genc, has not yet confirmed whether TSB would be sold after a potential Sabadell takeover. BBVA previously attempted to acquire Sabadell in 2020, but the talks fell through. [Extracted from the article]
- Published
- 2024
30. Anglo American Takeover Price Needs to Surpass £30/Share, Survey Shows.
- Author
-
Muller, Alexandra
- Subjects
PRICES ,MERGERS & acquisitions ,BID price ,DISINVESTMENT - Abstract
According to a survey conducted by Bloomberg, a takeover of Anglo American Plc would need to be priced at more than £30 per share, which is higher than the offer made by BHP Group Ltd. Traders and analysts believe that Anglo American shares are currently trading above the value of BHP's proposal, indicating that a higher bid is expected. The average acceptable price for a potential deal, as determined by the survey participants, was £30.43 per share. Analysts at Deutsche Bank suggest that there are two possible scenarios: either Anglo American is acquired at an improved price or the company fulfills some of the divestments proposed by BHP. However, there is no certainty that an offer will be made, and BHP has until May 22 to announce its intentions. [Extracted from the article]
- Published
- 2024
31. Anglo American Share Price Shows Traders Want a Sweeter Bid.
- Author
-
Muller, Alexandra
- Subjects
STOCK prices ,SPREAD (Finance) ,COPPER ,INVESTORS ,BID price ,DISCOUNT prices - Abstract
Traders are driving up the share price of Anglo American Plc, indicating their expectation of a higher bid from BHP Group Ltd. or another potential buyer. BHP's current proposal values Anglo at £31.1 billion ($38.9 billion) and includes a spin-off of two listed Anglo units. However, the current share price of Anglo American is 4% higher than the implied bid price, suggesting that traders anticipate a higher offer. Analysts and risk-arbitrage traders predict that other mining companies, such as Rio Tinto Plc and Glencore Plc, may also be interested in acquiring Anglo due to its significant copper production, which is in high demand for the energy transition. [Extracted from the article]
- Published
- 2024
32. Anglo American Share Price Shows Traders Envisage Sweeter Bid.
- Author
-
Muller, Alexandra
- Subjects
STOCK prices ,COPPER ,INVESTORS ,BID price ,DISCOUNT prices - Abstract
Traders are driving up the share price of Anglo American Plc, indicating that they anticipate a higher bid from the suitor or another interested party. BHP Group Ltd. has proposed a takeover of Anglo American, valuing the company at £31.1 billion ($38.9 billion). However, the current share price of Anglo American is above the implied bid price, suggesting that traders expect a higher offer. Analysts and risk-arbitrage traders predict that other mining companies, such as Rio Tinto Plc and Glencore Plc, may step in or that BHP will increase its offer. The demand for copper, a key metal for the energy transition, is driving interest in Anglo American's assets. [Extracted from the article]
- Published
- 2024
33. Allfunds, UK Stocks Touted as Favorite M&A Targets in Survey.
- Author
-
Muller, Alexandra and Ponthus, Julien
- Subjects
MERGERS & acquisitions ,GOING public (Securities) ,INVESTORS ,SMALL business ,STOCK funds ,PRIVATE equity - Abstract
According to an informal survey conducted by Bloomberg News, UK firms are expected to be popular targets for mergers and acquisitions (M&A) this year due to their low valuations. British stocks accounted for 70% of companies mentioned in the survey, with Allfunds Group Plc receiving the most votes. The FTSE 350 Index's significant discount compared to the MSCI World Index has attracted bargain hunters. Smaller UK companies, in particular, have seen increased attention from cash-rich private equity firms and corporate acquirers. There have already been several notable takeover offers this year, and investors are keeping an eye on Allfunds, which has drawn interest from investment firm Motive Partners. Overall, there is optimism that M&A activity in Europe will rebound this year. [Extracted from the article]
- Published
- 2024
34. Peel Hunt Says UK Small-Cap Stock Index on Track for Extinction.
- Author
-
Easton, Joe and Muller, Alexandra
- Subjects
SMALL capitalization stocks ,STOCK price indexes ,GOING public (Securities) ,STOCKS (Finance) ,STOCK prices ,EXCHANGE traded funds - Abstract
According to London stockbroker Peel Hunt Ltd, the UK small-cap stock index is at risk of disappearing by 2028 if the current level of takeover activity continues and the initial public offering market does not recover. The number of companies listed on the FTSE Small Cap Index has decreased from 160 in 2018 to 114 at the end of 2023. The combined market capitalization of firms on the small-cap index has also declined significantly. This decline is due to takeovers and a lack of new additions to the market. Peel Hunt suggests implementing measures to improve fund flows into the UK market, including addressing stamp duty. [Extracted from the article]
- Published
- 2024
35. Europe's IPO Market Not Yet Open to Unprofitable Tech, BofA Says.
- Author
-
Ponthus, Julien and Muller, Alexandra
- Subjects
GOING public (Securities) ,INTEREST rates ,STOCKS (Finance) - Abstract
According to Bank of America, profitability remains a crucial factor for tech startups looking to go public in Europe. Despite a recent increase in European IPOs, tech companies have struggled to raise funds on European exchanges for the past two years. In contrast, the US has seen successful IPOs from loss-making companies like Reddit Inc. and Astera Labs Inc. The European IPO market is expected to reopen once there are more interest rate decreases and sustained primary market activity globally. [Extracted from the article]
- Published
- 2024
36. Keysight Bids £1.2 Billion for Spirent, Overtaking Viavi.
- Author
-
Thomson, Amy and Muller, Alexandra
- Abstract
Keysight Technologies has made a bid to acquire Spirent Communications, a struggling UK telecom network testing company. Keysight's offer of 201.5 pence per share, including a special dividend, values Spirent's equity at £1.16 billion, surpassing the earlier bid from Viavi Solutions. Spirent, which provides automated testing for networks used by companies in 5G, cloud, and autonomous vehicle services, has faced challenges due to increasing costs and reduced spending by telecom customers. The deal is subject to approval from investors and regulators. The UK has seen increased takeover offers from foreign suitors due to low valuations and attractive M&A measures. [Extracted from the article]
- Published
- 2024
37. European IPO Rebound Gathers Pace With Biggest Quarter Since 2022.
- Author
-
Gopinath, Swetha and Muller, Alexandra
- Subjects
GOING public (Securities) - Abstract
Europe's initial public offerings (IPOs) are off to a strong start in 2024, with $5.7 billion raised through first-time share sales up to March 27. This puts Europe on track for its largest quarterly volume in 18 months. Skincare company Galderma Group AG's $2.6 billion offering accounted for almost half of the first-quarter total, with other companies such as Douglas AG, Athens International Airport SA, and RENK Group AG also contributing. While the number of IPOs in Europe is still low compared to previous years, more listings are expected after the Easter holiday. The success of Galderma's IPO may encourage other companies to go public, although some IPOs have not performed as well. Overall, European IPO activity is experiencing a resurgence due to good companies, increased investor confidence, and improved performance in funds. [Extracted from the article]
- Published
- 2024
38. UK Takeover Targets Ask for More Despite Best Premiums in Years.
- Author
-
Msika, Michael and Muller, Alexandra
- Subjects
STOCK prices - Abstract
UK companies are proving to be tough targets for bargain hunters looking for takeover opportunities. Even companies that have seen their share prices decline are rejecting generous offers, demanding higher premiums. Despite this, M&A premiums for UK companies are at their highest level since 2018. The UK's low valuations and attractive M&A valuation measures have made it a hotbed for deals. However, some analysts caution that walking away from a suitor based solely on valuation can be risky, as demonstrated by the example of THG Plc. [Extracted from the article]
- Published
- 2024
39. Biotech Rally Gets $100 Billion M&A Lift With More Deals to Come.
- Author
-
Pham, Lisa and Muller, Alexandra
- Subjects
MERGERS & acquisitions ,RUSSELL 2000 Index ,CASH & cash equivalents ,FATTY liver - Abstract
The biotech industry has experienced a surge in dealmaking, with 46 transactions worth over $100 billion announced last year. This increase in activity has led to a rally in biotech stocks, with the Russell 2000 Index Biotechnology Subsector rising nearly 60% since October. Many pharmaceutical companies are seeking deals to revitalize their drug pipelines, as patent expiries pose a challenge. The top 20 pharmaceutical firms have significant cash reserves, providing them with the means to pursue mergers and acquisitions. Immunology, obesity, and cancer have been popular areas for M&A, and fatty liver disease could be the next focus. Experimental treatments have attracted the most attention, with companies like Novartis, Sanofi, and Johnson & Johnson making significant acquisitions. Overall, the industry is experiencing continued innovation and strong stock performance. [Extracted from the article]
- Published
- 2024
40. UK Blank-Check Company's Cash Turns It From Buyer to Target.
- Author
-
Muller, Alexandra
- Subjects
STOCKS (Finance) ,MERGERS & acquisitions ,EQUITY stake ,INVESTORS ,TARGET acquisition - Abstract
Belluscura Plc, a medical-device company listed on the London Stock Exchange, issued $7 million of stock to acquire $6 million in cash from TMT Acquisition Plc, a blank-check company. Blank-check companies are typically created to acquire existing businesses, not to be acquired themselves. However, TMT Acquisition found a way to use its cash balance to finance Belluscura in exchange for an equity stake, rather than returning the money to investors. This deal allows Belluscura to access the funds needed for its development and increases its ability to execute its sales pipeline and strategy. [Extracted from the article]
- Published
- 2024
41. Morgan Stanley Strategists See M&A Surging as Confidence Builds.
- Author
-
Muller, Alexandra
- Subjects
MERGERS & acquisitions ,CONFIDENCE ,BONDS (Finance) ,ECONOMIC expansion ,BULL markets - Abstract
According to a report by Morgan Stanley, global mergers and acquisitions (M&A) are expected to increase by 50% this year due to recovering corporate confidence and sustained economic growth. The report highlights health care, real estate, and technology as the most attractive sectors for M&A. Potential acquisition candidates include companies such as Acadia Pharmaceuticals Inc., Lumentum Holdings Inc., ITV Plc, Aston Martin Lagonda Global Holdings Plc, Basic-Fit NV, and Eutelsat Communications. The headwinds that previously hindered deal-making have eased, with global equity markets rallying, high-yield bond issuance increasing, and corporate cash levels remaining high. However, recession risk and regulation are still seen as significant obstacles to M&A activity. [Extracted from the article]
- Published
- 2024
42. Breast Cancer-Derived Exosomes Alter Macrophage Polarization via gp130/STAT3 Signaling
- Author
-
Ham, Sunyoung, primary, Lima, Luize G., additional, Chai, Edna Pei Zhi, additional, Muller, Alexandra, additional, Lobb, Richard J., additional, Krumeich, Sophie, additional, Wen, Shu Wen, additional, Wiegmans, Adrian P., additional, and Möller, Andreas, additional
- Published
- 2018
- Full Text
- View/download PDF
43. Manufacturer perspectives on content transparency and material health in the US building products industry
- Author
-
Muller, Alexandra A
- Subjects
Material health ,Sustainability ,Health and environmental sciences ,Programs ,Surgery ,Toxicology ,Building products ,Social sciences - Abstract
Flawed U.S. federal regulation of chemicals has resulted in a materials market that undervalues human and environmental health in favor of the more traditional attributes of price, performance and aesthetics. In the building products industry, global, dynamic supply chains and proprietary information concerns further complicate the task of assessing the material health of products. Voluntary material health programs in the green building industry are intended to incentivize the manufacture and selection of safer products by getting companies to gather and assess ingredient, hazard and risk information from their supply chain. Building product manufacturers considered early adopters of the main material health programs of interest were interviewed and surveyed in order to identify the barriers they face to further program adoption and disclosure of product content and hazard information. The research reinforced findings that data collection requirements should be further aligned between different material health programs in order to streamline the process for manufacturers. Release of appropriate levels of information for consumers is also crucial to incentivizing informed decision-making. Supplier engagement and consumer education were identified as pathways to accelerating the demand and release of better information. Addressing these barriers is important to progress, as voluntary measures are likely to remain the most efficient pathway to a healthier materials market.
- Published
- 2016
44. Additional file 1: of Making the invisible visible: a systematic review of sexual minority womenâ s health in Southern Africa
- Author
-
Muller, Alexandra and Tonda Hughes
- Abstract
Overview of reviewed journal articles and key findings. Table of reviewed journal articles, with information on country, demographics, and key findings. (PDF 321 kb)
- Published
- 2016
- Full Text
- View/download PDF
45. Additional file 2: of Making the invisible visible: a systematic review of sexual minority womenâ s health in Southern Africa
- Author
-
Muller, Alexandra and Tonda Hughes
- Abstract
PRISMA checklist. Checklist for PRISMA criteria for systematic reviews. (PDF 191 kb)
- Published
- 2016
- Full Text
- View/download PDF
46. Estudio de meta-análisis del efecto de estimulación eléctrica en la fuerza de corte de la carne de vacuno
- Author
-
Xavier, Cristina, Gonzales-Barron, Ursula, Muller, Alexandra, and Cadavez, Vasco
- Subjects
Meta-analysis ,Shear force ,Electrical stimulation ,Beef meat - Abstract
The objective of this work was to use meta-analysis to estimate the effect size of the electrical stimulation on beef tenderness through the study of the measurements of shear force. Eight independent studies were used based on comparison of shear force measurements on the Longissimus dorsi and Longissimus lumborum in cattle carcasses subject to electrical stimulation and unstimulated carcasses. For each study, the mean effect size and standard error was calculated in order to apply a random-effects meta-analysis model. The meta-analysis demonstrated that the electrical stimulation on beef carcasses decreases the values of shear-force of meat by an average of 1.34 kgf. Thus, this study confirmed the positive effect of the electrical stimulation on the beef meat tenderness. However, the effect size displayed high variation among studies which can be attributed to differences in their experimental conditions. Esta investigación se realizó dentro del proyecto PTDC/AGR- TEC/3107/2012, financiado por la Fundación Portuguesa de Ciencia y Tecnología (FCT)/Fondos Europeos de Desarrollo Regional (FEDER). La Dra. Gonzales-Barron agradece todo el apoyo financiero provisto por la FCT a través del programa "investigador fellowship (IF/00570) info:eu-repo/semantics/publishedVersion
- Published
- 2015
47. UK Plc Attracts Wave of Takeover Offers From Foreign Suitors.
- Author
-
Muller, Alexandra and Nair, Dinesh
- Subjects
PURCHASING agents ,MERGERS & acquisitions ,SMALL business - Abstract
The UK has seen a surge in mergers and acquisitions as foreign buyers take advantage of the country's underperforming stock market. Direct Line Insurance Group and Currys both rejected bids from overseas buyers, while Wincanton received an offer from a US logistics provider, sparking a bidding war with its French suitor. The lower valuations of UK assets and the weak pound make UK firms attractive to foreign buyers. However, most of the interest is focused on smaller companies, as deal activity among FTSE 100 firms remains slow due to borrowing costs and economic concerns. [Extracted from the article]
- Published
- 2024
48. Shein Tempts London With Prospect of Biggest-Ever Listing.
- Author
-
Jaisinghani, Sagarika, Muller, Alexandra, and Wickham, Alex
- Subjects
GOING public (Securities) ,FORCED labor ,NETWORK governance - Abstract
Shein, a popular fast fashion brand founded in China, is considering a multi-billion dollar initial public offering (IPO) in London, which could potentially be the largest IPO in the city's history. However, the company is also applying to list in New York, but faces political and regulatory challenges in the US, including accusations of using cotton from forced labor in the Xinjiang region. The UK Chancellor of the Exchequer has held talks with Shein's executive chairman about a London listing, but the plans may face opposition in the UK as well. The potential listing of Shein in London could provide a boost to the city's market, but concerns about the company's supply chain and the ethics of fast fashion may attract scrutiny. The UK government is considering measures to attract more companies to list in London, but there are concerns about diluting listing rules too much. [Extracted from the article]
- Published
- 2024
49. Shein Tempts London With the Prospect of Biggest-Ever Listing.
- Author
-
Jaisinghani, Sagarika, Muller, Alexandra, and Mayes, Joe
- Subjects
GOING public (Securities) ,FORCED labor ,NETWORK governance ,ALTERNATIVE investments - Abstract
Shein, a popular fast fashion brand founded in China, is considering a multi-billion dollar initial public offering (IPO) in London, which could potentially be the largest IPO in the city's history. However, there are concerns about whether the plan will come to fruition due to political and regulatory hurdles in the US, where Shein is applying to list. The company has faced scrutiny from Chinese authorities and accusations of using cotton from forced labor in the Xinjiang region. While a London listing could provide a boost to the city's market, some analysts are skeptical and believe Shein may choose Hong Kong or New York instead. The UK government is exploring measures to attract more companies to list in London, including the introduction of a tax-free savings account for investing in British stocks. [Extracted from the article]
- Published
- 2024
50. Currys Takeover Fight Spurs Talk of More Retail M&A.
- Author
-
Easton, Joe and Muller, Alexandra
- Subjects
MERGERS & acquisitions ,COVID-19 pandemic ,STOCK prices ,STAY-at-home orders ,RETAIL industry - Abstract
Currys Plc, a London-based electronics retailer, has attracted takeover interest, leading to speculation about potential targets in the European retail sector. Shares of Currys surged 38% on Monday due to the possibility of a bidding war between Elliott Investment Management LP and JD.com Inc. Other companies in the industry, such as AO World Plc, Ceconomy AG, and Fnac Darty SA, also experienced stock price increases. Despite the improvement in macro conditions, these retailers are currently trading at significant discounts compared to their valuations during the COVID-19 lockdowns. Analysts and traders suggest that a takeout price for Currys would need to be raised to around 75 pence per share, well above Elliott's preliminary offer of 62 pence. Other British retail firms, including Hotel Chocolat Group Plc, ASOS Plc, Ocado Group Plc, and Halfords Group Plc, have also been the subject of takeover speculation. In November, it was reported that JD.com was exploring the possibility of acquiring a stake in Ceconomy AG, a German consumer electronics firm. [Extracted from the article]
- Published
- 2024
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