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1. Experience of the first adult-focussed undiagnosed disease program in Australia (AHA-UDP): solving rare and puzzling genetic disorders is ageless

Author

Wallis, M, Bodek, SD, Munro, J, Rafehi, H, Bennett, MF, Ye, Z, Schneider, A, Gardiner, F, Valente, G, Murdoch, E, Uebergang, E, Hunter, J, Stutterd, C, Huq, A, Salmon, L, Scheffer, I, Eratne, D, Meyn, S, Fong, CY, John, T, Mullen, S, White, SM, Brown, NJ, McGillivray, G, Chen, J, Richmond, C, Hughes, A, Krzesinski, E, Fennell, A, Chambers, B, Santoreneos, R, Le Fevre, A, Hildebrand, MS, Bahlo, M, Christodoulou, J, Delatycki, M, Berkovic, SF, Wallis, M, Bodek, SD, Munro, J, Rafehi, H, Bennett, MF, Ye, Z, Schneider, A, Gardiner, F, Valente, G, Murdoch, E, Uebergang, E, Hunter, J, Stutterd, C, Huq, A, Salmon, L, Scheffer, I, Eratne, D, Meyn, S, Fong, CY, John, T, Mullen, S, White, SM, Brown, NJ, McGillivray, G, Chen, J, Richmond, C, Hughes, A, Krzesinski, E, Fennell, A, Chambers, B, Santoreneos, R, Le Fevre, A, Hildebrand, MS, Bahlo, M, Christodoulou, J, Delatycki, M, and Berkovic, SF

Abstract

BACKGROUND: Significant recent efforts have facilitated increased access to clinical genetics assessment and genomic sequencing for children with rare diseases in many centres, but there remains a service gap for adults. The Austin Health Adult Undiagnosed Disease Program (AHA-UDP) was designed to complement existing UDP programs that focus on paediatric rare diseases and address an area of unmet diagnostic need for adults with undiagnosed rare conditions in Victoria, Australia. It was conducted at a large Victorian hospital to demonstrate the benefits of bringing genomic techniques currently used predominantly in a research setting into hospital clinical practice, and identify the benefits of enrolling adults with undiagnosed rare diseases into a UDP program. The main objectives were to identify the causal mutation for a variety of diseases of individuals and families enrolled, and to discover novel disease genes. METHODS: Unsolved patients in whom standard genomic diagnostic techniques such as targeted gene panel, exome-wide next generation sequencing, and/or chromosomal microarray, had already been performed were recruited. Genome sequencing and enhanced genomic analysis from the research setting were applied to aid novel gene discovery. RESULTS: In total, 16/50 (32%) families/cases were solved. One or more candidate variants of uncertain significance were detected in 18/50 (36%) families. No candidate variants were identified in 16/50 (32%) families. Two novel disease genes (TOP3B, PRKACB) and two novel genotype-phenotype correlations (NARS, and KMT2C genes) were identified. Three out of eight patients with suspected mosaic tuberous sclerosis complex had their diagnosis confirmed which provided reproductive options for two patients. The utility of confirming diagnoses for patients with mosaic conditions (using high read depth sequencing and ddPCR) was not specifically envisaged at the onset of the project, but the flexibility to offer recruitment and analyses on

Published
2024

2. An iPSC line (FINi003-A) from a male with late-onset developmental and epileptic encephalopathy caused by a heterozygous p.E1211K variant in the SCN2A gene encoding the voltage-gated sodium channel Nav1.2

Author

Ovchinnikov, DA, Jong, S, Cuddy, C, Dalby, K, Devinsky, O, Mullen, S, Maljevic, S, Petrou, S, Ovchinnikov, DA, Jong, S, Cuddy, C, Dalby, K, Devinsky, O, Mullen, S, Maljevic, S, and Petrou, S

Abstract

Many developmental and epileptic encephalopathies (DEEs) result from variants in cation channel genes. Using mRNA transfection, we generated and characterised an induced pluripotent stem cell (iPSC) line from the fibroblasts of a male late-onset DEE patient carrying a heterozygous missense variant (E1211K) in Nav1.2(SCN2A) protein. The iPSC line displays features characteristic of the human iPSCs, colony morphology and expression of pluripotency-associated marker genes, ability to produce derivatives of all three embryonic germ layers, and normal karyotype without SNP array-detectable abnormalities. We anticipate that this iPSC line will aid in the modelling and development of precision therapies for this debilitating condition.

Published
2024

6. Primary Results Of The REVEALPLAQUE Study: A Prospective Quantitative Assessment Of AI-based CCTA Plaque Volume Compared With IVUS

Author

Narula, J., primary, Stuckey, T., additional, Nakazawa, G., additional, Maehara, A., additional, Matsumura, M., additional, Petersen, K., additional, Mirza, S., additional, Ng, N., additional, Mullen, S., additional, Schaap, M., additional, Leipsic, J., additional, Rogers, C., additional, Taylor, C., additional, Yacoub, H., additional, Gupta, H., additional, Matsuo, H., additional, and Rinehart, S., additional

Published
2023
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9. Properties of Rubble-Pile Asteroid (101955) Bennu from OSIRIS-REx Imaging and Thermal Analysis

Author

DellaGiustina, D. N, Emery, J. P, Golish, D. R, Rozitis, B, Bennett, C. A, Burke, K. N, Ballouz, R.-L, Becker, K. J, Christensen, P. R, Drouet d’Aubigny, C. Y, Hamilton, V. E, Reuter, D. C, Rizk, B, Simon, A. A, Asphaug, E, Bandfield, J. L, Barnouin, O. S, Barucci, M. A, Binzel, R. P, Bottke, W. F, Bowles, N. E, Campins, H, Clark, B. C, Clark, B. E, Connolly, H. C., Jr, Daly, M. G, de Leon, J, Delbo, M, Deshapriya, J. D. P, Fornasier, S, Hergenrother, C. W, Jawin, E. R, Howell, E. S, Kaplan, H. H, Kareta, T. R, Corre, L. Le, Li, J.-Y, Licandro, J, Lim, L. F, Michel, P, Molaro, J, Nolan, M. C, Popescu, M, Rizos Garcia, J. L, Ryan, A, Schwartz, S. R, Shultz, N, Siegler, M. A, Smith, P. H, Tatsumi, E, Thomas, C. A, Walsh, K. J, Wolner, C. W. V, Zou, X.-D, Lauretta, D. S, Highsmith, D. E, Small, J, Vokrouhlick, D, Brown, E, Hanna, K. L. Donaldson, Warren, T, Brunet, C, Chicoine, R. A, Desjardins, S, Gaudreau, D, Haltigin, T, Millington-Veloza, S, Rubi, A, Aponte, J, Gorius, N, Lunsford, A, Allen, B, Grindlay, J, Guevel, D, Hoak, D, Hong, J, Schrader, D. L, Bayron, J, Golubov, O, Sánchez, P, Stromberg, J, Hirabayashi, M, Hartzell, C. M, Oliver, S, Rascon, M, Harch, A, Joseph, J, Squyres, S, Richardson, D, McGraw, L, Ghent, R, Al Asad, M. M, Johnson, C. L, Philpott, L, Susorney, H. C. M, Cloutis, E. A, Hanna, R. D, Ciceri, F, Hildebrand, A. R, Ibrahim, E.-M, Breitenfeld, L, Glotch, T, Rogers, A. D, Ferrone, S, Fernandez, Y, Chang, W, Cheuvront, A, Trang, D, Tachibana, S, Yurimoto, H, Brucato, J. R, Poggiali, G, Pajola, M, Dotto, E, Mazzotta Epifani, E, Crombie, M. K, Lantz, C, Izawa, M. R. M, Leon, J. de, Clemett, S, Thomas-Keprta, K, Van wal, S, Yoshikawa, M, Bellerose, J, Bhaskaran, S, Boyles, C, Chesley, S. R, Elder, C. M, Farnocchia, D, Harbison, A, Kennedy, B, Knight, A, Martinez-Vlasoff, N, Mastrodemos, N, McElrath, T, Owen, W, Park, R, Rush, B, Swanson, L, Takahashi, Y, Velez, D, Yetter, K, Thayer, C, Adam, C, Antreasian, P, Bauman, J, Bryan, C, Carcich, B, Corvin, M, Geeraert, J, Hoffman, J, Leonard, J. M, Lessac-Chenen, E, Levine, A, McAdams, J, McCarthy, L, Nelson, D, Page, B, Pelgrift, B, Sahr, E, Stakkestad, K, Stanbridge, D, Wibben, D, Williams, B, Williams, K, Wolff, P, Hayne, P, Kubitschek, D, Fulchignoni, M, Hasselmann, P, Merlin, F, Praet, A, Bierhaus, E. B, Billett, O, Boggs, A, Buck, B, Carlson-Kelly, S, Cerna, J, Chaffin, K, Church, E, Coltrin, M, Daly, J, Deguzman, A, Dubisher, R, Eckart, D, Ellis, D, Falkenstern, P, Fisher, A, Fisher, M. E, Fleming, P, Fortney, K, Francis, S, Freund, S, Gonzales, S, Haas, P, Hasten, A, Hauf, D, Hilbert, A, Howell, D, Jaen, F, Jayakody, N, Jenkins, M, Johnson, K, Lefevre, M, Ma, H, Mario, C, Martin, K, May, C, McGee, M, Miller, B, Miller, C, Miller, G, Mirfakhrai, A, Muhl, E, Norman, C, Olds, R, Parish, C, Ryle, M, Schmitzer, M, Sherman, P, Skeen, M, Susak, M, Sutter, B, Tran, Q, Welch, C, Witherspoon, R, Wood, J, Zareski, J, Arvizu-Jakubicki, M, Audi, E, Bandrowski, R, Becker, T. L, Bendall, S, Bloomenthal, H, Blum, D, Boynton, W. V, Brodbeck, J, Chojnacki, M, Colpo, A, Contreras, J, Cutts, J, Dean, D, Diallo, B, Drinnon, D, Drozd, K, Enos, H. L, Enos, R, Fellows, C, Ferro, T, Fisher, M. R, Fitzgibbon, G, Fitzgibbon, M, Forelli, J, Forrester, T, Galinsky, I, Garcia, R, Gardner, A, Habib, N, Hamara, D, Hammond, D, Hanley, K, Harshman, K, Herzog, K, Hill, D, Hoekenga, C, Hooven, S, Huettner, E, Janakus, A, Jones, J, Kidd, J, Kingsbury, K, Balram-Knutson, S. S, Koelbel, L, Kreiner, J, Lambert, D, Lewin, C, Lovelace, B, Loveridge, M, Lujan, M, Maleszewski, C. K, Malhotra, R, Marchese, K, McDonough, E, Mogk, N, Morrison, V, Morton, E, Munoz, R, Nelson, J, Padilla, J, Pennington, R, Polit, A, Ramos, N, Reddy, V, Riehl, M, Roper, H. L, Salazar, S, Selznick, S, Stewart, S, Sutton, S, Swindle, T, Tang, Y. H, Westermann, M, Worden, D, Zega, T, Zeszut, Z, Bjurstrom, A, Bloomquist, L, Dickinson, C, Keates, E, Liang, J, Nifo, V, Taylor, A, Teti, F, Caplinger, M, Bowles, H, Carter, S, Dickenshied, S, Doerres, D, Fisher, T, Hagee, W, Hill, J, Miner, M, Noss, D, Piacentine, N, Smith, M, Toland, A, Wren, P, Bernacki, M, Pino Munoz, D, Watanabe, S.-I, Sandford, S. A, Aqueche, A, Ashman, B, Barker, M, Bartels, A, Berry, K, Bos, B, Burns, R, Calloway, A, Carpenter, R, Castro, N, Cosentino, R, Donaldson, J, Dworkin, J. P, Cook, J. Elsila, Emr, C, Everett, D, Fennell, D, Fleshman, K, Folta, D, Gallagher, D, Garvin, J, Getzandanner, K, Glavin, D, Hull, S, Hyde, K, Ido, H, Ingegneri, A, Jones, N, Kaotira, P, Liounis, A, Lorentson, C, Lorenz, D, Lyzhoft, J, Mazarico, E. M, Mink, R, Moore, W, Moreau, M, Mullen, S, Nagy, J, Neumann, G, Nuth, J, Poland, D, Rhoads, L, Rieger, S, Rowlands, D, Sallitt, D, Scroggins, A, Shaw, G, Swenson, J, Vasudeva, P, Wasser, M, Zellar, R, Grossman, J, Johnston, G, Morris, M, Wendel, J, Burton, A, Keller, L. P, McNamara, L, Messenger, S, Nakamura-Messenger, K, Nguyen, A, Righter, K, Queen, E, Bellamy, K, Dill, K, Gardner, S, Giuntini, M, Key, B, Kissell, J, Patterson, D, Vaughan, D, Wright, B, Gaskell, R. W, Le Corre, L, Molaro, J. L, Palmer, E. E, Tricarico, P, Weirich, J. R, Ireland, T, Tait, K, Bland, P, Anwar, S, Bojorquez-Murphy, N, Haberle, C. W, Mehall, G, Rios, K, Franchi, I, Beddingfield, C. B, Marshall, J, Brack, D. N, French, A. S, McMahon, J. W, Scheeres, D. J, McCoy, T. J, Russell, S, Killgore, M, Chodas, M, Lambert, M, Masterson, R. A, Freemantle, J, Seabrook, J. A, Craft, K, Daly, R. T, Ernst, C, Espiritu, R. C, Holdridge, M, Jones, M, Nair, A. H, Nguyen, L, Peachey, J, Perry, M. E, Plescia, J, Roberts, J. H, Steele, R, Turner, R, Backer, J, Edmundson, K, Mapel, J, Milazzo, M, Sides, S, Manzoni, C, May, B, Libourel, G, Thuillet, F, and Marty, B

Subjects
Lunar And Planetary Science And Exploration
Abstract

Establishing the abundance and physical properties of regolith and boulders on asteroids is crucial for understanding the formation and degradation mechanisms at work on their surfaces. Using images and thermal data from NASA's Origins, Spectral Interpretation, Resource Identification, and Security-Regolith Explorer (OSIRIS-REx) spacecraft, we show that asteroid (101955) Bennu's surface is globally rough, dense with boulders, and low in albedo. The number of boulders is surprising given Bennu's moderate thermal inertia, suggesting that simple models linking thermal inertia to particle size do not adequately capture the complexity relating these properties. At the same time, we find evidence for a wide range of particle sizes with distinct albedo characteristics. Our findings imply that ages of Bennu's surface particles span from the disruption of the asteroid's parent body (boulders) to recent in situ production (micrometre-scale particles).

Published
2019
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10. Changing the culture: a qualitative study exploring research capacity in local government

Author

Homer, C, Woodall, J, Freeman, C, South, J, Cooke, J, Holliday, J, Hartley, A, Mullen, S, Homer, C, Woodall, J, Freeman, C, South, J, Cooke, J, Holliday, J, Hartley, A, and Mullen, S

Abstract

Background Local government has become a key constituent for addressing health inequalities and influencing the health of individuals and communities in England. Lauded as an effective approach to tackle the multiple determinants of health, there are concerns that generating and utilising research evidence to inform decision-making and action is a challenge. This research was conducted in a local authority situated in the north of England and addressed the research question – ‘What is the capacity to collaborate and deliver research?’. The study explored the assets that exist to foster a stronger research culture, identified barriers and opportunities for developing research capacity, and how a sustainable research system could be developed to impact on local residents’ health and reduce health inequalities. Methods This was a qualitative study utilising semi-structured interviews and focus groups. The study used an embedded researcher (ER) who was digitally embedded within the local authority for four months to conduct the data collection. Senior Managers were purposively sampled from across the local authority to take part in interviews. Three focus groups included representation from across the local authority. Framework analysis was conducted to develop the themes which were informed by the Research Capacity Development framework. Results Tensions between research led decision making and the political and cultural context of local government were identified as a barrier to developing research which addressed health inequalities. Research was not prioritised through an organisational strategy and was led sporadically by research active employees. A recognition across leaders that a culture shift to an organisation which used research evidence to develop policy and commission services was needed. Building relationships and infrastructure across local government, place-based collaborators and academic institutions was required. The embedded researcher approach is o

Published
2022

13. Borgs are giant extrachromosomal elements with the potential to augment methane oxidation

Author

West-Roberts J, Michael J. Wilkins, Jennifer A. Doudna, Kenneth H. Williams, Basem Al-Shayeb, Mullen S, Alexander Crits-Christoph, Marie Charlotte Schoelmerich, Luis E. Valentin-Alvarado, Rohan Sachdeva, and Jillian F. Banfield

Subjects
biology, Phylogenetics, Evolutionary biology, Chemistry, Extrachromosomal DNA, Anaerobic oxidation of methane, Direct repeat, biology.organism_classification, Gene, Genome, Genomic organization, Archaea
Abstract

SummaryAnaerobic methane oxidation exerts a key control on greenhouse gas emissions 1, yet factors that modulate the activity of microorganisms performing this function remain little explored. In studying groundwater, sediments, and wetland soil where methane production and oxidation occur, we discovered extraordinarily large, diverse DNA sequences that primarily encode hypothetical proteins. Four curated, complete genomes are linear, up to ~1 Mbp in length and share genome organization, including replicore structure, long inverted terminal repeats, and genome-wide unique perfect tandem direct repeats that are intergenic or generate amino acid repeats. We infer that these are a new type of archaeal extrachromosomal element with a distinct evolutionary origin. Gene sequence similarity, phylogeny, and local divergence of sequence composition indicate that many of their genes were assimilated from methane-oxidizing Methanoperedens archaea. We refer to these elements as “Borgs”. We identified at least 19 different Borg types coexisting with Methanoperedens in four distinct ecosystems. Borg genes expand redox and respiratory capacity (e.g., clusters of multiheme cytochromes), ability to respond to changing environmental conditions, and likely augment Methanoperedens capacity for methane oxidation (e.g., methyl coenzyme M reductase). By this process, Borgs could play a previously unrecognized role in controlling greenhouse gas emissions.

Published
2021

15. Craters, boulders and regolith of (101955) Bennu indicative of an old and dynamic surface

Author

Walsh, KJ, Jawin, ER, Ballouz, R-L, Barnouin, OS, Bierhaus, EB, Jr, CHC, Molaro, JL, McCoy, TJ, Delbo', M, Hartzell, CM, Pajola, M, Schwartz, SR, Trang, D, Asphaug, E, Becker, KJ, Beddingfield, CB, Bennett, CA, Bottke, WF, Burke, KN, Clark, BC, Daly, MG, Dellagiustina, DN, Dworkin, JP, Elder, CM, Golish, DR, Hildebrand, AR, Malhotra, R, Marshall, J, Michel, P, Nolan, MC, Perry, ME, Rizk, B, Ryan, A, Sandford, SA, Scheeres, DJ, Susorney, HCM, Thuillet, F, Lauretta, DS, Highsmith, DE, Small, J, Vokrouhlicky, D, Bowles, NE, Brown, E, Hanna, KLD, Warren, T, Brunet, C, Chicoine, RA, Desjardins, S, Gaudreau, D, Haltigin, T, Millington-Veloza, S, Rubi, A, Aponte, J, Gorius, N, Lunsford, A, Allen, B, Grindlay, J, Guevel, D, Hoak, D, Hong, J, Schrader, DL, Bayron, J, Golubov, O, Sanchez, P, Stromberg, J, Hirabayashi, M, Oliver, S, Rascon, M, Harch, A, Joseph, J, Squyres, S, Richardson, D, Emery, JP, McGraw, L, Ghent, R, Binzel, RP, Asad, MM, Johnson, CL, Philpott, L, Cloutis, EA, Hanna, RD, Ciceri, F, Ibrahim, E-M, Breitenfeld, L, Glotch, T, Rogers, AD, Clark, BE, Ferrone, S, Thomas, CA, Campins, H, Fernandez, Y, Chang, W, Cheuvront, A, Tachibana, S, Yurimoto, H, Brucato, JR, Poggiali, G, Dotto, E, Epifani, EM, Crombie, MK, Lantz, C, Izawa, MRM, De Leon, J, Licandro, J, Garcia, JLR, Clemett, S, Thomas-Keprta, K, Van Wal, S, Yoshikawa, M, Bellerose, J, Bhaskaran, S, Boyles, C, Chesley, SR, Farnocchia, D, Harbison, A, Kennedy, B, Knight, A, Martinez-Vlasoff, N, Mastrodemos, N, McElrath, T, Owen, W, Park, R, Rush, B, Swanson, L, Takahashi, Y, Velez, D, Yetter, K, Thayer, C, Adam, C, Antreasian, P, Bauman, J, Bryan, C, Carcich, B, Corvin, M, Geeraert, J, Hoffman, J, Leonard, JM, Lessac-Chenen, E, Levine, A, McAdams, J, McCarthy, L, Nelson, D, Page, B, Pelgrift, J, Sahr, E, Stakkestad, K, Stanbridge, D, Wibben, D, Williams, B, Williams, K, Wolff, P, Hayne, P, Kubitschek, D, Barucci, MA, Deshapriya, JDP, Fornasier, S, Fulchignoni, M, Hasselmann, P, Merlin, F, Praet, A, Billett, O, Boggs, A, Buck, B, Carlson-Kelly, S, Cerna, J, Chaffin, K, Church, E, Coltrin, M, Daly, J, Deguzman, A, Dubisher, R, Eckart, D, Ellis, D, Falkenstern, P, Fisher, A, Fisher, ME, Fleming, P, Fortney, K, Francis, S, Freund, S, Gonzales, S, Haas, P, Hasten, A, Hauf, D, Hilbert, A, Howell, D, Jaen, F, Jayakody, N, Jenkins, M, Johnson, K, Lefevre, M, Ma, H, Mario, C, Martin, K, May, C, McGee, M, Miller, B, Miller, C, Miller, G, Mirfakhrai, A, Muhle, E, Norman, C, Olds, R, Parish, C, Ryle, M, Schmitzer, M, Sherman, P, Skeen, M, Susak, M, Sutter, B, Tran, Q, Welch, C, Witherspoon, R, Wood, J, Zareski, J, Arvizu-Jakubicki, M, Audi, E, Bandrowski, R, Becker, TL, Bendall, S, Bloomenthal, H, Blum, D, Boynton, WV, Brodbeck, J, Chojnacki, M, Colpo, A, Contreras, J, Cutts, J, D'Aubigny, CYD, Dean, D, Diallo, B, Drinnon, D, Drozd, K, Enos, HL, Enos, R, Fellows, C, Ferro, T, Fisher, MR, Fitzgibbon, G, Fitzgibbon, M, Forelli, J, Forrester, T, Galinsky, I, Garcia, R, Gardner, A, Habib, N, Hamara, D, Hammond, D, Hanley, K, Harshman, K, Hergenrother, CW, Herzog, K, Hill, D, Hoekenga, C, Hooven, S, Howell, ES, Huettner, E, Janakus, A, Jones, J, Kareta, TR, Kidd, J, Kingsbury, K, Balram-Knutson, SS, Koelbel, L, Kreiner, J, Lambert, D, Lewin, C, Lovelace, B, Loveridge, M, Lujan, M, Maleszewski, CK, Marchese, K, McDonough, E, Mogk, N, Morrison, V, Morton, E, Munoz, R, Nelson, J, Padilla, J, Pennington, R, Polit, A, Ramos, N, Reddy, V, Riehl, M, Roper, HL, Salazar, S, Selznick, S, Shultz, N, Smith, PH, Stewart, S, Sutton, S, Swindle, T, Tang, YH, Westermann, M, Wolner, CWV, Worden, D, Zega, T, Zeszut, Z, Bjurstrom, A, Bloomquist, L, Dickinson, C, Keates, E, Liang, J, Nifo, V, Taylor, A, Teti, F, Caplinger, M, Bowles, H, Carter, S, Dickenshied, S, Doerres, D, Fisher, T, Hagee, W, Hill, J, Miner, M, Noss, D, Piacentine, N, Smith, M, Toland, A, Wren, P, Bernacki, M, Munoz, DP, Watanabe, S-I, Aqueche, A, Ashman, B, Barker, M, Bartels, A, Berry, K, Bos, B, Burns, R, Calloway, A, Carpenter, R, Castro, N, Cosentino, R, Donaldson, J, Cook, JE, Emr, C, Everett, D, Fennell, D, Fleshman, K, Folta, D, Gallagher, D, Garvin, J, Getzandanner, K, Glavin, D, Hull, S, Hyde, K, Ido, H, Ingegneri, A, Jones, N, Kaotira, P, Lim, LF, Liounis, A, Lorentson, C, Lorenz, D, Lyzhoft, J, Mazarico, EM, Mink, R, Moore, W, Moreau, M, Mullen, S, Nagy, J, Neumann, G, Nuth, J, Poland, D, Reuter, DC, Rhoads, L, Rieger, S, Rowlands, D, Sallitt, D, Scroggins, A, Shaw, G, Simon, AA, Swenson, J, Vasudeva, P, Wasser, M, Zellar, R, Grossman, J, Johnston, G, Morris, M, Wendel, J, Burton, A, Keller, LP, McNamara, L, Messenger, S, Nakamura-Messenger, K, Nguyen, A, Righter, K, Queen, E, Bellamy, K, Dill, K, Gardner, S, Giuntini, M, Key, B, Kissell, J, Patterson, D, Vaughan, D, Wright, B, Gaskell, RW, Le Corre, L, Li, J-Y, Palmer, EE, Siegler, MA, Tricarico, P, Weirich, JR, Zou, X-D, Ireland, T, Tait, K, Bland, P, Anwar, S, Bojorquez-Murphy, N, Christensen, PR, Haberle, CW, Mehall, G, Rios, K, Franchi, I, Rozitis, B, Brack, DN, French, AS, McMahon, JW, Russell, S, Killgore, M, Hamilton, VE, Kaplan, HH, Bandfield, JL, Chodas, M, Lambert, M, Masterson, RA, Freemantle, J, Seabrook, JA, Craft, K, Daly, RT, Ernst, C, Espiritu, RC, Holdridge, M, Jones, M, Nair, AH, Nguyen, L, Peachey, J, Plescia, J, Roberts, JH, Steele, R, Turner, R, Backer, J, Edmundson, K, Mapel, J, Milazzo, M, Sides, S, Manzoni, C, May, B, Delbo, M, Libourel, G, Marty, B, Team, O-R, Centro di Ateneo di Studi e Attività Spaziali 'Giuseppe Colombo' (CISAS), Universita degli Studi di Padova, Laboratoire de Géophysique Interne et Tectonophysique (LGIT), Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Laboratoire Central des Ponts et Chaussées (LCPC)-Institut des Sciences de la Terre (ISTerre), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-PRES Université de Grenoble-Institut de recherche pour le développement [IRD] : UR219-Institut national des sciences de l'Univers (INSU - CNRS)-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-PRES Université de Grenoble-Institut de recherche pour le développement [IRD] : UR219-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), ASU School of Earth and Space Exploration (SESE), Arizona State University [Tempe] (ASU), IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], NASA Goddard Space Flight Center (GSFC), National Dairy Research Institute, SETI Institute, Institute of Northern Engineering, 455 Duckering Bldg, Lunar and Planetary Laboratory [Tucson] (LPL), University of Arizona, Centre de Mise en Forme des Matériaux (CEMEF), Centre National de la Recherche Scientifique (CNRS)-PSL Research University (PSL)-MINES ParisTech - École nationale supérieure des mines de Paris, Institut des Sciences de la Terre (ISTerre), Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de recherche pour le développement [IRD] : UR219-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), and ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015)

Subjects
Near-Earth object, 010504 meteorology & atmospheric sciences, Mass movement, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], Geomorphology, 010502 geochemistry & geophysics, 01 natural sciences, Billion years, Regolith, Astrobiology, [SPI]Engineering Sciences [physics], Asteroids comets and Kuiper belt, Impact crater, Asteroid, General Earth and Planetary Sciences, Asteroid belt, Early solar system, Geology, 0105 earth and related environmental sciences
Abstract

著者人数: 38名ほか (The OSIRIS-REx Team: 所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): Van wal, S; 吉川, 真; 渡邊, 誠一郎), Number of authors: 38 and The OSIRIS-REx Team (Affiliation. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency(JAXA)(ISAS): Van wal, S; Yoshikawa, Makoto; Watanabe, Sei-icihro), Accepted: 2019-02-11, 資料番号: SA1190038000

Published
2019

16. Somatic IDH1 variant ( p.R132C) in an adult male with Maffucci syndrome

Author

Brown, NJ, Ye, Z, Stutterd, C, Jayasinghe, SI, Schneider, A, Mullen, S, Mandelstam, SA, Hildebrand, MS, Brown, NJ, Ye, Z, Stutterd, C, Jayasinghe, SI, Schneider, A, Mullen, S, Mandelstam, SA, and Hildebrand, MS

Abstract

Maffucci syndrome is a rare, highly variable somatic mosaic condition, and well-known cancer-related gain-of-function variants in either the IDH1 or IDH2 genes have been found in the affected tissues of most reported individuals. Features include benign enchondroma and spindle-cell hemangioma, with a recognized increased risk of various malignancies. Fewer than 200 affected individuals have been reported; therefore, accurate estimates of malignancy risk are difficult to quantify and recommended surveillance guidelines are not available. The same gain-of-function IDH1 and IDH2 variants are also implicated in a variety of other benign and malignant tumors. An adult male presented with several soft palpable lesions on the right upper limb. Imaging and histopathology raised the possibility of Maffucci syndrome. DNA was extracted from peripheral blood lymphocytes and tissue surgically resected from a spindle-cell hemangioma. Sanger sequencing and droplet digital polymerase chain reaction (PCR) analysis of the IDH1 gene were performed. We identified a somatic mosaic c.394C > T (p.R132C) variant in exon 5 of IDH1, in DNA derived from hemangioma tissue at ∼17% variant allele fraction. This variant was absent in DNA derived from blood. This variant has been identified in the affected tissue of most reported individuals with Maffucci syndrome. Although this individual has a potentially targetable variant, and there is a recognized risk of malignant transformation in this condition, a decision was made not to intervene with an IDH1 inhibitor. The reasons and prospects for therapy in this condition are discussed.

Published
2021

19. 1-Year Impact on Medical Practice and Clinical Outcomes of FFRCT:The ADVANCE Registry

Author

Patel, M.R., Norgaard, B.L., Fairbairn, T.A., Nieman, K., Akasaka, T., Berman, D.S., Raff, G.L., Koweek, L.M.H., Pontone, G., Kawasaki, T., Sand, N.P.R., Jensen, J.M., Amano, T., Poon, M., Ovrehus, K.A., Sonck, J., Rabbat, M.G., Mullen, S., Bruyne, B. de, Rogers, C., Matsuo, H., Bax, J.J., and Leipsic, J.

Subjects
FFRCT, coronary computed tomography angiography, fractional flow reserve, FFR, major adverse cardiac events, clinical outcomes, clinical practice
Abstract

OBJECTIVES The 1-year data from the international ADVANCE (Assessing Diagnostic Value of Non-invasive FFRCT in Coronary Care) Registry of patients undergoing coronary computed tomography angiography (CTA) was used to evaluate the relationship of fractional flow reserve derived from coronary CTA (FFRCT) with downstream care and clinical outcomes.BACKGROUND Guidelines for management of chest pain using noninvasive imaging pathways are based on short- to intermediate-term outcomes.METHODS Patients (N = 5,083) evaluated for clinically suspected coronary artery disease and in whom atherosclerosis was identified by coronary CTA were prospectively enrolled at 38 international sites from July 15, 2015, to October 20, 2017. Demographics, symptom status, coronary CTA and FFRCT findings and resultant site-based treatment plans, and clinical outcomes through 1 year were recorded and adjudicated by a blinded core laboratory. Major adverse cardiac events (MACE), death, myocardial infarction (MI), and acute coronary syndrome leading to urgent revascularization were captured.RESULTS At 1 year, 449 patients did not have follow-up data. Revascularization occurred in 1,208 (38.40%) patients with an FFRCT 0.80 (relative risk [RR]: 6.87; 95% confidence interval [CI]: 5.59 to 8.45; p < 0.001). MACE occurred in 55 patients, 43 events occurred in patients with an FFRCT 0.80 (RR: 1.81; 95% CI: 0.96 to 3.43; p = 0.06). Time to first event (all-cause death or MI) occurred in 38 (1.20%) patients with an FFRCT 0.80 (RR: 1.92; 95% CI: 0.96 to 3.85; p = 0.06). Time to first event (cardiovascular death or MI) occurred cardiovascular death or MI occurred more in patients with an FFRCT 0.80 (25 [0.80%] vs. 3 [0.20%]; RR: 4.22; 95% CI: 1.28 to 13.95; p = 0.01).CONCLUSIONS The 1-year outcomes from the ADVANCE FFRCT Registry show low rates of events in all patients, with less revascularization and a trend toward lower MACE and significantly lower cardiovascular death or MI in patients with a negative FFRCT compared with patients with abnormal FFRCT values. (Assessing Diagnostic Value of Non-invasive FFRCT in Coronary Wave [ADVANCE]; NCT02499679) (C) 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

Published
2020

20. Inherited RORB pathogenic variants: Overlap of photosensitive genetic generalized and occipital lobe epilepsy

Author

Sadleir, LG, de Valles-Ibanez, G, King, C, Coleman, M, Mossman, S, Paterson, S, Nguyen, J, Berkovic, SF, Mullen, S, Bahlo, M, Hildebrand, MS, Mefford, HC, Scheffer, IE, Sadleir, LG, de Valles-Ibanez, G, King, C, Coleman, M, Mossman, S, Paterson, S, Nguyen, J, Berkovic, SF, Mullen, S, Bahlo, M, Hildebrand, MS, Mefford, HC, and Scheffer, IE

Abstract

Variants in RORB have been reported in eight individuals with epilepsy, with phenotypes ranging from eyelid myoclonia with absence epilepsy to developmental and epileptic encephalopathies. We identified novel RORB variants in 11 affected individuals from four families. One was from whole genome sequencing and three were from RORB screening of three epilepsy cohorts: developmental and epileptic encephalopathies (n = 1021), overlap of generalized and occipital epilepsy (n = 84), and photosensitivity (n = 123). Following interviews and review of medical records, individuals' seizure and epilepsy syndromes were classified. Three novel missense variants and one exon 3 deletion were predicted to be pathogenic by in silico tools, not found in population databases, and located in key evolutionary conserved domains. Median age at seizure onset was 3.5 years (0.5-10 years). Generalized, predominantly absence and myoclonic, and occipital seizures were seen in all families, often within the same individual (6/11). All individuals with epilepsy were photosensitive, and seven of 11 had cognitive abnormalities. Electroencephalograms showed generalized spike and wave and/or polyspike and wave. Here we show a striking RORB phenotype of overlap of photosensitive generalized and occipital epilepsy in both individuals and families. This is the first report of a gene associated with this overlap of epilepsy syndromes.

Published
2020

23. Hybridization and speciation*

Author

Abbott, R., Albach, D., Ansell, S., Arntzen, J. W., Baird, S. J. E., Bierne, N., Boughman, J., Brelsford, A., Buerkle, C. A., Buggs, R., Butlin, R. K., Dieckmann, U., Eroukhmanoff, F., Grill, A., Cahan, S. H., Hermansen, J. S., Hewitt, G., Hudson, A. G., Jiggins, C., Jones, J., Keller, B., Marczewski, T., Mallet, J., Martinez-Rodriguez, P., Möst, M., Mullen, S., Nichols, R., Nolte, A. W., Parisod, C., Pfennig, K., Rice, A. M., Ritchie, M. G., Seifert, B., Smadja, C. M., Stelkens, R., Szymura, J. M., Väinölä, R., Wolf, J. B. W., and Zinner, D.

Published
2013
Full Text
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30. Evidence for widespread hydrated minerals on asteroid (101955) Bennu

Author

Hamilton, VE, Simon, AA, Christensen, PR, Reuter, DC, Clark, BE, Barucci, MA, Bowles, NE, Boynton, WV, Brucato, JR, Cloutis, EA, Jr, CHC, Hannah, KLD, Emery, JP, Enos, HL, Fornasier, S, Haberle, CW, Hanna, RD, Howell, ES, Kaplan, HH, Keller, LP, Lantz, C, Li, J-Y, Lim, LF, McCoy, TJ, Merlins, F, Nolan, MC, Praet, A, Rozitis, B, Sandford, SA, Schrader, DL, Thomas, CA, Zou, X-D, Lauretta, DS, Highsmith, DE, Small, J, Vokrouhlicky, D, Brown, E, Warren, T, Brunet, C, Chicoine, RA, Desjardins, S, Gaudreau, D, Haltigin, T, Millington-Veloza, S, Rubi, A, Aponte, J, Gorius, N, Lunsford, A, Allen, B, Grindlay, J, Guevel, D, Hoak, D, Hong, J, Bayron, J, Golubov, O, Sanchez, P, Stromberg, J, Hirabayashi, M, Hartzell, CM, Oliver, S, Rascon, M, Harch, A, Joseph, J, Squyres, S, Richardson, D, McGraw, L, Ghent, R, Binzel, RP, Al Asad, MM, Johnson, CL, Philpott, L, Susorney, HCM, Ciceri, F, Hildebrand, AR, Ibrahim, E-M, Breitenfeld, L, Glotch, T, Rogers, AD, Ferrone, S, Campins, H, Fernandez, Y, Chang, W, Cheuvront, A, Trang, D, Tachibana, S, Yurimoto, H, Poggiali, G, Pajola, M, Dotto, E, Epifani, EM, Crombie, MK, Izawa, MRM, De Leon, J, Licandro, J, Garcia, JLR, Clemett, S, Thomas-Keprta, K, Van Wal, S, Yoshikawa, M, Bellerose, J, Bhaskaran, S, Boyles, C, Chesley, SR, Elder, CM, Farnocchia, D, Harbison, A, Kennedy, B, Knight, A, Martinez-Vlasoff, N, Mastrodemos, N, McElrath, T, Owen, W, Park, R, Rush, B, Swanson, L, Takahashi, Y, Velez, D, Yetter, K, Thayer, C, Adam, C, Antreasian, P, Bauman, J, Bryan, C, Carcich, B, Corvin, M, Geeraert, J, Hoffman, J, Leonard, JM, Lessac-Chenen, E, Levine, A, McAdams, J, McCarthy, L, Nelson, D, Page, B, Pelgrift, J, Sahr, E, Stakkestad, K, Stanbridge, D, Wibben, D, Williams, B, Williams, K, Wolff, P, Hayne, P, Kubitschek, D, Deshapriya, JDP, Fulchignoni, M, Hasselmann, P, Merlin, F, Bierhaus, EB, Billett, O, Boggs, A, Buck, B, Carlson-Kelly, S, Cerna, J, Chaffin, K, Church, E, Coltrin, M, Daly, J, Deguzman, A, Dubisher, R, Eckart, D, Ellis, D, Falkenstern, P, Fisher, A, Fisher, ME, Fleming, P, Fortney, K, Francis, S, Freund, S, Gonzales, S, Haas, P, Hasten, A, Hauf, D, Hilbert, A, Howell, D, Jaen, F, Jayakody, N, Jenkins, M, Johnson, K, Lefevre, M, Ma, H, Mario, C, Martin, K, May, C, McGee, M, Miller, B, Miller, C, Miller, G, Mirfakhrai, A, Muhle, E, Norman, C, Olds, R, Parish, C, Ryle, M, Schmitzer, M, Sherman, P, Skeen, M, Susak, M, Sutter, B, Tran, Q, Welch, C, Witherspoon, R, Wood, J, Zareski, J, Arvizu-Jakubicki, M, Asphaug, E, Audi, E, Ballouz, R-L, Bandrowski, R, Becker, KJ, Becker, TL, Bendall, S, Bennett, CA, Bloomenthal, H, Blum, D, Brodbeck, J, Burke, KN, Chojnacki, M, Colpo, A, Contreras, J, Cutts, J, D'Aubigny, CYD, Dean, D, Dellagiustina, DN, Diallo, B, Drinnon, D, Drozd, K, Enos, R, Fellows, C, Ferro, T, Fisher, MR, Fitzgibbon, G, Fitzgibbon, M, Forelli, J, Forrester, T, Galinsky, I, Garcia, R, Gardner, A, Golish, DR, Habib, N, Hamara, D, Hammond, D, Hanley, K, Harshman, K, Hergenrother, CW, Herzog, K, Hill, D, Hoekenga, C, Hooven, S, Huettner, E, Janakus, A, Jones, J, Kareta, TR, Kidd, J, Kingsbury, K, Balram-Knutson, SS, Koelbel, L, Kreiner, J, Lambert, D, Lewin, C, Lovelace, B, Loveridge, M, Lujan, M, Maleszewski, CK, Malhotra, R, Marchese, K, McDonough, E, Mogk, N, Morrison, V, Morton, E, Munoz, R, Nelson, J, Padilla, J, Pennington, R, Polit, A, Ramos, N, Reddy, V, Riehl, M, Rizk, B, Roper, HL, Salazar, S, Schwartz, SR, Selznick, S, Shultz, N, Smith, PH, Stewart, S, Sutton, S, Swindle, T, Tang, YH, Westermann, M, Wolner, CWV, Worden, D, Zega, T, Zeszut, Z, Bjurstrom, A, Bloomquist, L, Dickinson, C, Keates, E, Liang, J, Nifo, V, Taylor, A, Teti, F, Caplinger, M, Bowles, H, Carter, S, Dickenshied, S, Doerres, D, Fisher, T, Hagee, W, Hill, J, Miner, M, Noss, D, Piacentine, N, Smith, M, Toland, A, Wren, P, Bernacki, M, Munoz, DP, Watanabe, S-I, Aqueche, A, Ashman, B, Barker, M, Bartels, A, Berry, K, Bos, B, Burns, R, Calloway, A, Carpenter, R, Castro, N, Cosentino, R, Donaldson, J, Dworkin, JP, Cook, JE, Emr, C, Everett, D, Fennell, D, Fleshman, K, Folta, D, Gallagher, D, Garvin, J, Getzandanner, K, Glavin, D, Hull, S, Hyde, K, Ido, H, Ingegneri, A, Jones, N, Kaotira, P, Liounis, A, Lorentson, C, Lorenz, D, Lyzhoft, J, Mazarico, EM, Mink, R, Moore, W, Moreau, M, Mullen, S, Nagy, J, Neumann, G, Nuth, J, Poland, D, Rhoads, L, Rieger, S, Rowlands, D, Sallitt, D, Scroggins, A, Shaw, G, Swenson, J, Vasudeva, P, Wasser, M, Zellar, R, Grossman, J, Johnston, G, Morris, M, Wendel, J, Burton, A, McNamara, L, Messenger, S, Nakamura-Messenger, K, Nguyen, A, Righter, K, Queen, E, Bellamy, K, Dill, K, Gardner, S, Giuntini, M, Key, B, Kissell, J, Patterson, D, Vaughan, D, Wright, B, Gaskell, RW, Le Corre, L, Molaro, JL, Palmer, EE, Siegler, MA, Tricarico, P, Weirich, JR, Ireland, T, Tait, K, Bland, P, Anwar, S, Bojorquez-Murphy, N, Mehall, G, Rios, K, Franchi, I, Beddingfield, CB, Marshall, J, Brack, DN, French, AS, McMahon, JW, Scheeres, DJ, Jawin, ER, Russell, S, Killgore, M, Bottke, WF, Walsh, KJ, Bandfield, JL, Clark, BC, Chodas, M, Lambert, M, Masterson, RA, Daly, MG, Freemantle, J, Seabrook, JA, Barnouin, OS, Craft, K, Daly, RT, Ernst, C, Espiritu, RC, Holdridge, M, Jones, M, Nair, AH, Nguyen, L, Peachey, J, Perry, ME, Plescia, J, Roberts, JH, Steele, R, Turner, R, Backer, J, Edmundson, K, Mapel, J, Milazzo, M, Sides, S, Manzoni, C, May, B, Delbo, M, Libourel, G, Michel, P, Ryan, A, Thuillet, F, Marty, B, Team, O-R, Southwest Research Institute [Boulder] (SwRI), ASU School of Earth and Space Exploration (SESE), Arizona State University [Tempe] (ASU), NASA Goddard Space Flight Center (GSFC), Ithaca College, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Department of Atmospheric, Oceanic and Planetary Physics [Oxford] (AOPP), University of Oxford, Lunar and Planetary Laboratory [Tucson] (LPL), University of Arizona, INAF - Osservatorio Astrofisico di Arcetri (OAA), Istituto Nazionale di Astrofisica (INAF), Department of Geography [Winnipeg], University of Winnipeg, Department of Physics, Rowan University, Glassboro, Rowan University, Department of Earth and Planetary Sciences [Knoxville], The University of Tennessee [Knoxville], Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Department of Geological Sciences, Jackson School of Geosciences, University of Texas at Austin [Austin], The Swiss Light Source (SLS) (SLS-PSI), Paul Scherrer Institute (PSI), NASA Johnson Space Center (JSC), NASA, Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Université Paris-Sud - Paris 11 (UP11), Planetary Science Institute [Tucson] (PSI), Smithsonian Institution, National Museum of Natural History, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), The Open University [Milton Keynes] (OU), NASA Ames Research Center Cooperative for Research in Earth Science in Technology (ARC-CREST), NASA Ames Research Center (ARC), Center for Meteorite Studies [Tempe], Northern Arizona University [Flagstaff], Centre de Mise en Forme des Matériaux (CEMEF), Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), University of Oxford [Oxford], Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Paris Sud Orsay, and MINES ParisTech - École nationale supérieure des mines de Paris

Subjects
Mineral hydration, Thermal infrared, 010504 meteorology & atmospheric sciences, Comets and Kuiper belt, Astronomy and Astrophysics, Mineralogy, 01 natural sciences, Article, Asteroids, Astrobiology, [SPI.MAT]Engineering Sciences [physics]/Materials, [SPI]Engineering Sciences [physics], Asteroid, Chondrite, Meteoritics, 0103 physical sciences, Early solar system, Spectral data, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], 010303 astronomy & astrophysics, Geology, 0105 earth and related environmental sciences
Abstract

著者人数: 33名ほか (The OSIRIS-REx Team: 所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): Van wal, S; 吉川, 真; 渡邊, 誠一郎), Number of authors: 33 and The OSIRIS-REx Team (Affiliation. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency(JAXA)(ISAS): Van wal, S; Yoshikawa, Makoto; Watanabe, Sei-icihro), Accepted: 2019-02-12, 資料番号: SA1190036000

Published
2019

31. The dynamic geophysical environment of (101955) Bennu based on OSIRIS-REx measurements

Author

Scheeres, DJ, McMahon, JW, French, AS, Brack, DN, Chesley, SR, Farnocchia, D, Takahashi, Y, Leonard, JM, Geeraert, J, Page, B, Antreasian, P, Getzandanner, K, Rowlands, D, Mazarico, EM, Small, J, Highsmith, DE, Moreau, M, Emery, JP, Rozitis, B, Hirabayashi, M, Sanchez, P, Van Wal, S, Tricarico, P, Ballouz, R-L, Johnson, CL, Asad, MM, Susorney, HCM, Barnouin, OS, Daly, MG, Seabrook, JA, Gaskell, RW, Palmer, EE, Weirich, JR, Walsh, KJ, Jawin, ER, Bierhaus, EB, Michel, P, Bottke, WF, Nolan, MC, Jr, CHC, Lauretta, DS, Vokrouhlicky, D, Bowles, NE, Brown, E, Hanna, KLD, Warren, T, Brunet, C, Chicoine, RA, Desjardins, S, Gaudreau, D, Haltigin, T, Millington-Veloza, S, Rubi, A, Aponte, J, Gorius, N, Lunsford, A, Allen, B, Grindlay, J, Guevel, D, Hoak, D, Hong, J, Schrader, DL, Bayron, J, Golubov, O, Stromberg, J, Hartzell, CM, Oliver, S, Rascon, M, Harch, A, Joseph, J, Squyres, S, Richardson, D, McGraw, L, Ghent, R, Binzel, RP, Philpott, L, Cloutis, EA, Hanna, RD, Ciceri, F, Hildebrand, AR, Ibrahim, E-M, Breitenfeld, L, Glotch, T, Rogers, AD, Clark, BE, Ferrone, S, Thomas, CA, Campins, H, Fernandez, Y, Chang, W, Cheuvront, A, Trang, D, Tachibana, S, Yurimoto, H, Brucato, JR, Poggiali, G, Pajola, M, Dotto, E, Epifani, EM, Crombie, MK, Lantz, C, Izawa, MRM, De Leon, J, Licandro, J, Garcia, JL, Clemett, S, Thomas-Keprta, K, Yoshikawa, M, Bellerose, J, Bhaskaran, S, Boyles, C, Elder, CM, Harbison, A, Kennedy, B, Knight, A, Martinez-Vlasoff, N, Mastrodemos, N, McElrath, T, Owen, W, Park, R, Rush, B, Swanson, L, Velez, D, Yetter, K, Thayer, C, Adam, C, Bauman, J, Bryan, C, Carcich, B, Corvin, M, Hoffman, J, Lessac-Chenen, E, Levine, A, McAdams, J, McCarthy, L, Nelson, D, Pelgrift, J, Sahr, E, Stakkestad, K, Stanbridge, D, Wibben, D, Williams, B, Williams, K, Wolff, P, Hayne, P, Kubitschek, D, Barucci, MA, Deshapriya, JDP, Fornasier, S, Fulchignoni, M, Hasselmann, P, Merlin, F, Praet, A, Billett, O, Boggs, A, Buck, B, Carlson-Kelly, S, Cerna, J, Chaffin, K, Church, E, Coltrin, M, Daly, J, Deguzman, A, Dubisher, R, Eckart, D, Ellis, D, Falkenstern, P, Fisher, A, Fisher, ME, Fleming, P, Fortney, K, Francis, S, Freund, S, Gonzales, S, Haas, P, Hasten, A, Hauf, D, Hilbert, A, Howell, D, Jaen, F, Jayakody, N, Jenkins, M, Johnson, K, Lefevre, M, Ma, H, Mario, C, Martin, K, May, C, McGee, M, Miller, B, Miller, C, Miller, G, Mirfakhrai, A, Muhle, E, Norman, C, Olds, R, Parish, C, Ryle, M, Schmitzer, M, Sherman, P, Skeen, M, Susak, M, Sutter, B, Tran, Q, Welch, C, Witherspoon, R, Wood, J, Zareski, J, Arvizu-Jakubicki, M, Asphaug, E, Audi, E, Bandrowski, R, Becker, KJ, Becker, TL, Bendall, S, Bennett, CA, Bloomenthal, H, Blum, D, Boynton, WV, Brodbeck, J, Burke, KN, Chojnacki, M, Colpo, A, Contreras, J, Cutts, J, D'Aubigny, CYD, Dean, D, Dellagiustina, DN, Diallo, B, Drinnon, D, Drozd, K, Enos, HL, Enos, R, Fellows, C, Ferro, T, Fisher, MR, Fitzgibbon, G, Fitzgibbon, M, Forelli, J, Forrester, T, Galinsky, I, Garcia, R, Gardner, A, Golish, DR, Habib, N, Hamara, D, Hammond, D, Hanley, K, Harshman, K, Hergenrother, CW, Herzog, K, Hill, D, Hoekenga, C, Hooven, S, Howell, ES, Huettner, E, Janakus, A, Jones, J, Kareta, TR, Kidd, J, Kingsbury, K, Balram-Knutson, SS, Koelbel, L, Kreiner, J, Lambert, D, Lewin, C, Lovelace, B, Loveridge, M, Lujan, M, Maleszewski, CK, Malhotra, R, Marchese, K, McDonough, E, Mogk, N, Morrison, V, Morton, E, Munoz, R, Nelson, J, Padilla, J, Pennington, R, Polit, A, Ramos, N, Reddy, V, Riehl, M, Rizk, B, Roper, HL, Salazar, S, Schwartz, SR, Selznick, S, Shultz, N, Smith, PH, Stewart, S, Sutton, S, Swindle, T, Tang, YH, Westermann, M, Wolner, CWV, Worden, D, Zega, T, Zeszut, Z, Bjurstrom, A, Bloomquist, L, Dickinson, C, Keates, E, Liang, J, Nifo, V, Taylor, A, Teti, F, Caplinger, M, Bowles, H, Carter, S, Dickenshied, S, Doerres, D, Fisher, T, Hagee, W, Hill, J, Miner, M, Noss, D, Piacentine, N, Smith, M, Toland, A, Wren, P, Bernacki, M, Munoz, DP, Watanabe, S-I, Sandford, SA, Aqueche, A, Ashman, B, Barker, M, Bartels, A, Berry, K, Bos, B, Burns, R, Calloway, A, Carpenter, R, Castro, N, Cosentino, R, Donaldson, J, Dworkin, JP, Cook, JE, Emr, C, Everett, D, Fennell, D, Fleshman, K, Folta, D, Gallagher, D, Garvin, J, Glavin, D, Hull, S, Hyde, K, Ido, H, Ingegneri, A, Jones, N, Kaotira, P, Lim, LF, Liounis, A, Lorentson, C, Lorenz, D, Lyzhoft, J, Mink, R, Moore, W, Mullen, S, Nagy, J, Neumann, G, Nuth, J, Poland, D, Reuter, DC, Rhoads, L, Rieger, S, Sallitt, D, Scroggins, A, Shaw, G, Simon, AA, Swenson, J, Vasudeva, P, Wasser, M, Zellar, R, Grossman, J, Johnston, G, Morris, M, Wendel, J, Burton, A, Keller, LP, McNamara, L, Messenger, S, Nakamura-Messenger, K, Nguyen, A, Righter, K, Queen, E, Bellamy, K, Dill, K, Gardner, S, Giuntini, M, Key, B, Kissell, J, Patterson, D, Vaughan, D, Wright, B, Le Corre, L, Li, J-Y, Molaro, JL, Siegler, MA, Zou, X-D, Ireland, T, Tait, K, Bland, P, Anwar, S, Bojorquez-Murphy, N, Christensen, PR, Haberle, CW, Mehall, G, Rios, K, Franchi, I, Beddingfield, CB, Marshall, J, McCoy, TJ, Russell, S, Killgore, M, Hamilton, VE, Kaplan, HH, Bandfield, JL, Clark, BC, Chodas, M, Lambert, M, Masterson, RA, Freemantle, J, Craft, K, Daly, RT, Ernst, C, Espiritu, RC, Holdridge, M, Jones, M, Nair, AH, Nguyen, L, Peachey, J, Perry, ME, Plescia, J, Roberts, JH, Steele, R, Turner, R, Backer, J, Edmundson, K, Mapel, J, Milazzo, M, Sides, S, Manzoni, C, May, B, Delbo', M, Libourel, G, Ryan, A, Thuillet, F, Marty, B, Team, The OSIRIS-REx, USDA Agricultural Research Service [Maricopa, AZ] (USDA), United States Department of Agriculture (USDA), Dipartimento di Matematica, University of Pisa - Università di Pisa, Department of Geophysics [Sendai], Tohoku University [Sendai], KinetX Aerospace Inc., Institut de Recherche Interdisciplinaire sur les enjeux Sociaux - sciences sociales, politique, santé (IRIS), Université Paris 13 (UP13)-École des hautes études en sciences sociales (EHESS)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris sciences et lettres (PSL), Institut des Matériaux, de Microélectronique et des Nanosciences de Provence (IM2NP), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), The Open University [Milton Keynes] (OU), National Institute of Polar Research [Tokyo] (NiPR), IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Planetary Science Institute [Tucson] (PSI), Institute of Northern Engineering, 455 Duckering Bldg, Centre de Mise en Forme des Matériaux (CEMEF), Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Sorbonne Paris Cité (USPC)-École des hautes études en sciences sociales (EHESS)-Université Paris 13 (UP13), Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), and MINES ParisTech - École nationale supérieure des mines de Paris

Subjects
010504 meteorology & atmospheric sciences, biology, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Physics, Spin rate, Equator, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], Astronomy and Astrophysics, Geophysics, Astronomy and planetary science, biology.organism_classification, 01 natural sciences, Article, [SPI]Engineering Sciences [physics], Engineering, Asteroid, 0103 physical sciences, Roche lobe, Osiris, 010303 astronomy & astrophysics, Geology, 0105 earth and related environmental sciences
Abstract

著者人数: 41名ほか (The OSIRIS-REx Team: 所属. 宇宙航空研究開発機構宇宙科学研究所 (JAXA)(ISAS): Van wal, Stefaan; 吉川, 真; 渡邊, 誠一郎), Number of authors: 41 and The OSIRIS-REx Team (Affiliation. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS): Yoshikawa, Makoto; Watanabe, Sei-ichiro), Accepted: 2019-02-11, 資料番号: SA1180379000

Published
2019

33. The operational environment and rotational acceleration of asteroid (101955) Bennu from OSIRIS-REx observations

Author

Hergenrother, CW, Maleszewski, CK, Nolan, MC, Li, J-Y, d'Aubigny, CYD, Shelly, FC, Howell, ES, Kareta, TR, Izawa, MRM, Barucci, MA, Bierhaus, EB, Campins, H, Chesley, SR, Clark, BE, Christensen, EJ, DellaGiustina, DN, Fornasier, S, Golish, DR, Hartzell, CM, Rizk, B, Scheeres, DJ, Smith, PH, Zou, X-D, Lauretta, DS, Highsmith, DE, Small, J, Vokrouhlicky, D, Bowles, NE, Brown, E, Hanna, KLD, Warren, T, Brunet, C, Chicoine, RA, Desjardins, S, Gaudreau, D, Haltigin, T, Millington-Veloza, S, Rubi, A, Aponte, J, Gorius, N, Lunsford, A, Allen, B, Grindlay, J, Guevel, D, Hoak, D, Hong, J, Schrader, DL, Bayron, J, Golubov, O, Sanchez, P, Stromberg, J, Hirabayashi, M, Oliver, S, Rascon, M, Harch, A, Joseph, J, Squyres, S, Richardson, D, Emery, JP, McGraw, L, Ghent, R, Binzel, RP, Al Asad, MM, Johnson, CL, Philpott, L, Susorney, HCM, Cloutis, EA, Hanna, RD, Connolly, HC, Ciceri, F, Hildebrand, AR, Ibrahim, E-M, Breitenfeld, L, Glotch, T, Rogers, AD, Ferrone, S, Thomas, CA, Fernandez, Y, Chang, W, Cheuvront, A, Trang, D, Tachibana, S, Yurimoto, H, Brucato, JR, Poggiali, G, Pajola, M, Dotto, E, Epifani, EM, Crombie, MK, Lantz, C, de Leon, J, Licandro, J, Rizos Garcia, JL, Clemett, S, Thomas-Keprta, K, Van Wal, S, Yoshikawa, M, Bellerose, J, Bhaskaran, S, Boyles, C, Elder, CM, Farnocchia, D, Harbison, A, Kennedy, B, Knight, A, Martinez-Vlasoff, N, Mastrodemos, N, McElrath, T, Owen, W, Park, R, Rush, B, Swanson, L, Takahashi, Y, Velez, D, Yetter, K, Thayer, C, Adam, C, Antreasian, P, Bauman, J, Bryan, C, Carcich, B, Corvin, M, Geeraert, J, Hoffman, J, Leonard, JM, Lessac-Chenen, E, Levine, A, McAdams, J, McCarthy, L, Nelson, D, Page, B, Pelgrift, J, Sahr, E, Stakkestad, K, Stanbridge, D, Wibben, D, Williams, B, Williams, K, Wolff, P, Hayne, P, Kubitschek, D, Deshapriya, JDP, Fulchignoni, M, Hasselmann, P, Merlin, F, Praet, A, Billett, O, Boggs, A, Buck, B, Carlson-Kelly, S, Cerna, J, Chaffin, K, Church, E, Coltrin, M, Daly, J, Deguzman, A, Dubisher, R, Eckart, D, Ellis, D, Falkenstern, P, Fisher, A, Fisher, ME, Fleming, P, Fortney, K, Francis, S, Freund, S, Gonzales, S, Haas, P, Hasten, A, Hauf, D, Hilbert, A, Howell, D, Jaen, F, Jayakody, N, Jenkins, M, Johnson, K, Lefevre, M, Ma, H, Mario, C, Martin, K, May, C, McGee, M, Miller, B, Miller, C, Miller, G, Mirfakhrai, A, Muhle, E, Norman, C, Olds, R, Parish, C, Ryle, M, Schmitzer, M, Sherman, P, Skeen, M, Susak, M, Sutter, B, Tran, Q, Welch, C, Witherspoon, R, Wood, J, Zareski, J, Arvizu-Jakubicki, M, Asphaug, E, Audi, E, Ballouz, R-L, Bandrowski, R, Becker, KJ, Becker, TL, Bendall, S, Bennett, CA, Bloomenthal, H, Blum, D, Boynton, W, Brodbeck, J, Burke, KN, Chojnacki, M, Colpo, A, Contreras, J, Cutts, J, Dean, D, Diallo, B, Drinnon, D, Drozd, K, Enos, HL, Enos, R, Fellows, C, Ferro, T, Fisher, MR, Fitzgibbon, G, Fitzgibbon, M, Forelli, J, Forrester, T, Galinsky, I, Garcia, R, Gardner, A, Habib, N, Hamara, D, Hammond, D, Hanley, K, Harshman, K, Herzog, K, Hill, D, Hoekenga, C, Hooven, S, Huettner, E, Janakus, A, Jones, J, Kidd, J, Kingsbury, K, Balram-Knutson, SS, Koelbel, L, Kreiner, J, Lambert, D, Lewin, C, Lovelace, B, Loveridge, M, Lujan, M, Malhotra, R, Marchese, K, McDonough, E, Mogk, N, Morrison, V, Morton, E, Munoz, R, Nelson, J, Padilla, J, Pennington, R, Polit, A, Ramos, N, Reddy, V, Riehl, M, Roper, HL, Salazar, S, Schwartz, SR, Selznick, S, Shultz, N, Stewart, S, Sutton, S, Swindle, T, Tang, YH, Westermann, M, Wolner, CW, Worden, D, Zega, T, Zeszut, Z, Bjurstrom, A, Bloomquist, L, Dickinson, C, Keates, E, Liang, J, Nifo, V, Taylor, A, Teti, F, Caplinger, M, Bowles, H, Carter, S, Dickenshied, S, Doerres, D, Fisher, T, Hagee, W, Hill, J, Miner, M, Noss, D, Piacentine, N, Smith, M, Toland, A, Wren, P, Bernacki, M, Munoz, DP, Watanabe, S, Sandford, SA, Aqueche, A, Ashman, B, Barker, M, Bartels, A, Berry, K, Bos, B, Burns, R, Calloway, A, Carpenter, R, Castro, N, Cosentino, R, Donaldson, J, Dworkin, JP, Cook, JE, Emr, C, Everett, D, Fennell, D, Fleshman, K, Folta, D, Gallagher, D, Garvin, J, Getzandanner, K, Glavin, D, Hull, S, Hyde, K, Ido, H, Ingegneri, A, Jones, N, Kaotira, P, Lim, LF, Liounis, A, Lorentson, C, Lorenz, D, Lyzhoft, J, Mazarico, EM, Mink, R, Moore, W, Moreau, M, Mullen, S, Nagy, J, Neumann, G, Nuth, J, Poland, D, Reuter, DC, Rhoads, L, Rieger, S, Rowlands, D, Sallitt, D, Scroggins, A, Shaw, G, Simon, AA, Swenson, J, Vasudeva, P, Wasser, M, Zellar, R, Grossman, J, Johnston, G, Morris, M, Wendel, J, Burton, A, Keller, LP, McNamara, L, Messenger, S, Nakamura-Messenger, K, Nguyen, A, Righter, K, Queen, E, Bellamy, K, Dill, K, Gardner, S, Giuntini, M, Key, B, Kissell, J, Patterson, D, Vaughan, D, Wright, B, Gaskell, RW, Le Corre, L, Molaro, JL, Palmer, EE, Siegler, MA, Tricarico, P, Weirich, JR, Ireland, T, Tait, K, Bland, P, Anwar, S, Bojorquez-Murphy, N, Christensen, PR, Haberle, CW, Mehall, G, Rios, K, Franchi, I, Rozitis, B, Beddingfield, CB, Marshall, J, Brack, DN, French, AS, McMahon, JW, Jawin, ER, McCoy, TJ, Russell, S, Killgore, M, Bottke, WF, Hamilton, VE, Kaplan, HH, Walsh, KJ, Bandfield, JL, Clark, BC, Chodas, M, Lambert, M, Masterson, RA, Daly, MG, Freemantle, J, Seabrook, JA, Barnouin, OS, Craft, K, Daly, RT, Ernst, C, Espiritu, RC, Holdridge, M, Jones, M, Nair, AH, Nguyen, L, Peachey, J, Perry, ME, Plescia, J, Roberts, JH, Steele, R, Turner, R, Backer, J, Edmundson, K, Mapel, J, Milazzo, M, Sides, S, Manzoni, C, May, B, Delbo, M, Libourel, G, Michel, P, Ryan, A, Thuillet, F, Marty, B, Hergenrother, CW, Maleszewski, CK, Nolan, MC, Li, J-Y, d'Aubigny, CYD, Shelly, FC, Howell, ES, Kareta, TR, Izawa, MRM, Barucci, MA, Bierhaus, EB, Campins, H, Chesley, SR, Clark, BE, Christensen, EJ, DellaGiustina, DN, Fornasier, S, Golish, DR, Hartzell, CM, Rizk, B, Scheeres, DJ, Smith, PH, Zou, X-D, Lauretta, DS, Highsmith, DE, Small, J, Vokrouhlicky, D, Bowles, NE, Brown, E, Hanna, KLD, Warren, T, Brunet, C, Chicoine, RA, Desjardins, S, Gaudreau, D, Haltigin, T, Millington-Veloza, S, Rubi, A, Aponte, J, Gorius, N, Lunsford, A, Allen, B, Grindlay, J, Guevel, D, Hoak, D, Hong, J, Schrader, DL, Bayron, J, Golubov, O, Sanchez, P, Stromberg, J, Hirabayashi, M, Oliver, S, Rascon, M, Harch, A, Joseph, J, Squyres, S, Richardson, D, Emery, JP, McGraw, L, Ghent, R, Binzel, RP, Al Asad, MM, Johnson, CL, Philpott, L, Susorney, HCM, Cloutis, EA, Hanna, RD, Connolly, HC, Ciceri, F, Hildebrand, AR, Ibrahim, E-M, Breitenfeld, L, Glotch, T, Rogers, AD, Ferrone, S, Thomas, CA, Fernandez, Y, Chang, W, Cheuvront, A, Trang, D, Tachibana, S, Yurimoto, H, Brucato, JR, Poggiali, G, Pajola, M, Dotto, E, Epifani, EM, Crombie, MK, Lantz, C, de Leon, J, Licandro, J, Rizos Garcia, JL, Clemett, S, Thomas-Keprta, K, Van Wal, S, Yoshikawa, M, Bellerose, J, Bhaskaran, S, Boyles, C, Elder, CM, Farnocchia, D, Harbison, A, Kennedy, B, Knight, A, Martinez-Vlasoff, N, Mastrodemos, N, McElrath, T, Owen, W, Park, R, Rush, B, Swanson, L, Takahashi, Y, Velez, D, Yetter, K, Thayer, C, Adam, C, Antreasian, P, Bauman, J, Bryan, C, Carcich, B, Corvin, M, Geeraert, J, Hoffman, J, Leonard, JM, Lessac-Chenen, E, Levine, A, McAdams, J, McCarthy, L, Nelson, D, Page, B, Pelgrift, J, Sahr, E, Stakkestad, K, Stanbridge, D, Wibben, D, Williams, B, Williams, K, Wolff, P, Hayne, P, Kubitschek, D, Deshapriya, JDP, Fulchignoni, M, Hasselmann, P, Merlin, F, Praet, A, Billett, O, Boggs, A, Buck, B, Carlson-Kelly, S, Cerna, J, Chaffin, K, Church, E, Coltrin, M, Daly, J, Deguzman, A, Dubisher, R, Eckart, D, Ellis, D, Falkenstern, P, Fisher, A, Fisher, ME, Fleming, P, Fortney, K, Francis, S, Freund, S, Gonzales, S, Haas, P, Hasten, A, Hauf, D, Hilbert, A, Howell, D, Jaen, F, Jayakody, N, Jenkins, M, Johnson, K, Lefevre, M, Ma, H, Mario, C, Martin, K, May, C, McGee, M, Miller, B, Miller, C, Miller, G, Mirfakhrai, A, Muhle, E, Norman, C, Olds, R, Parish, C, Ryle, M, Schmitzer, M, Sherman, P, Skeen, M, Susak, M, Sutter, B, Tran, Q, Welch, C, Witherspoon, R, Wood, J, Zareski, J, Arvizu-Jakubicki, M, Asphaug, E, Audi, E, Ballouz, R-L, Bandrowski, R, Becker, KJ, Becker, TL, Bendall, S, Bennett, CA, Bloomenthal, H, Blum, D, Boynton, W, Brodbeck, J, Burke, KN, Chojnacki, M, Colpo, A, Contreras, J, Cutts, J, Dean, D, Diallo, B, Drinnon, D, Drozd, K, Enos, HL, Enos, R, Fellows, C, Ferro, T, Fisher, MR, Fitzgibbon, G, Fitzgibbon, M, Forelli, J, Forrester, T, Galinsky, I, Garcia, R, Gardner, A, Habib, N, Hamara, D, Hammond, D, Hanley, K, Harshman, K, Herzog, K, Hill, D, Hoekenga, C, Hooven, S, Huettner, E, Janakus, A, Jones, J, Kidd, J, Kingsbury, K, Balram-Knutson, SS, Koelbel, L, Kreiner, J, Lambert, D, Lewin, C, Lovelace, B, Loveridge, M, Lujan, M, Malhotra, R, Marchese, K, McDonough, E, Mogk, N, Morrison, V, Morton, E, Munoz, R, Nelson, J, Padilla, J, Pennington, R, Polit, A, Ramos, N, Reddy, V, Riehl, M, Roper, HL, Salazar, S, Schwartz, SR, Selznick, S, Shultz, N, Stewart, S, Sutton, S, Swindle, T, Tang, YH, Westermann, M, Wolner, CW, Worden, D, Zega, T, Zeszut, Z, Bjurstrom, A, Bloomquist, L, Dickinson, C, Keates, E, Liang, J, Nifo, V, Taylor, A, Teti, F, Caplinger, M, Bowles, H, Carter, S, Dickenshied, S, Doerres, D, Fisher, T, Hagee, W, Hill, J, Miner, M, Noss, D, Piacentine, N, Smith, M, Toland, A, Wren, P, Bernacki, M, Munoz, DP, Watanabe, S, Sandford, SA, Aqueche, A, Ashman, B, Barker, M, Bartels, A, Berry, K, Bos, B, Burns, R, Calloway, A, Carpenter, R, Castro, N, Cosentino, R, Donaldson, J, Dworkin, JP, Cook, JE, Emr, C, Everett, D, Fennell, D, Fleshman, K, Folta, D, Gallagher, D, Garvin, J, Getzandanner, K, Glavin, D, Hull, S, Hyde, K, Ido, H, Ingegneri, A, Jones, N, Kaotira, P, Lim, LF, Liounis, A, Lorentson, C, Lorenz, D, Lyzhoft, J, Mazarico, EM, Mink, R, Moore, W, Moreau, M, Mullen, S, Nagy, J, Neumann, G, Nuth, J, Poland, D, Reuter, DC, Rhoads, L, Rieger, S, Rowlands, D, Sallitt, D, Scroggins, A, Shaw, G, Simon, AA, Swenson, J, Vasudeva, P, Wasser, M, Zellar, R, Grossman, J, Johnston, G, Morris, M, Wendel, J, Burton, A, Keller, LP, McNamara, L, Messenger, S, Nakamura-Messenger, K, Nguyen, A, Righter, K, Queen, E, Bellamy, K, Dill, K, Gardner, S, Giuntini, M, Key, B, Kissell, J, Patterson, D, Vaughan, D, Wright, B, Gaskell, RW, Le Corre, L, Molaro, JL, Palmer, EE, Siegler, MA, Tricarico, P, Weirich, JR, Ireland, T, Tait, K, Bland, P, Anwar, S, Bojorquez-Murphy, N, Christensen, PR, Haberle, CW, Mehall, G, Rios, K, Franchi, I, Rozitis, B, Beddingfield, CB, Marshall, J, Brack, DN, French, AS, McMahon, JW, Jawin, ER, McCoy, TJ, Russell, S, Killgore, M, Bottke, WF, Hamilton, VE, Kaplan, HH, Walsh, KJ, Bandfield, JL, Clark, BC, Chodas, M, Lambert, M, Masterson, RA, Daly, MG, Freemantle, J, Seabrook, JA, Barnouin, OS, Craft, K, Daly, RT, Ernst, C, Espiritu, RC, Holdridge, M, Jones, M, Nair, AH, Nguyen, L, Peachey, J, Perry, ME, Plescia, J, Roberts, JH, Steele, R, Turner, R, Backer, J, Edmundson, K, Mapel, J, Milazzo, M, Sides, S, Manzoni, C, May, B, Delbo, M, Libourel, G, Michel, P, Ryan, A, Thuillet, F, and Marty, B

Abstract

During its approach to asteroid (101955) Bennu, NASA's Origins, Spectral Interpretation, Resource Identification, and Security-Regolith Explorer (OSIRIS-REx) spacecraft surveyed Bennu's immediate environment, photometric properties, and rotation state. Discovery of a dusty environment, a natural satellite, or unexpected asteroid characteristics would have had consequences for the mission's safety and observation strategy. Here we show that spacecraft observations during this period were highly sensitive to satellites (sub-meter scale) but reveal none, although later navigational images indicate that further investigation is needed. We constrain average dust production in September 2018 from Bennu's surface to an upper limit of 150 g s-1 averaged over 34 min. Bennu's disk-integrated photometric phase function validates measurements from the pre-encounter astronomical campaign. We demonstrate that Bennu's rotation rate is accelerating continuously at 3.63 ± 0.52 × 10-6 degrees day-2, likely due to the Yarkovsky-O'Keefe-Radzievskii-Paddack (YORP) effect, with evolutionary implications.

Published
2019

34. Design and Implementation of the Hangman Gbit/S Network

Author

Watson, G., primary, Ooi, S., additional, Skellern, D., additional, Cunningham, D., additional, Banks, D., additional, Calamvokis, C., additional, Chidzey, R., additional, Hayes, M., additional, King, P., additional, Marshall, A., additional, Mullen, S., additional, Riley, M., additional, and Wray, W., additional

Published
1994
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38. Real-world clinical utility and impact on clinical decision-making of coronary computed tomography angiography-derived fractional flow reserve: lessons from the ADVANCE Registry

Author

Fairbairn, T.A. (Timothy A.), Nieman, K. (Koen), Akasaka, T. (Takashi), Nørgaard, B. (Bjarne), Berman, D.S. (Daniel), Raff, G.L. (Gilbert), Hurwitz-Koweek, L.M. (Lynne M.), Pontone, G. (Gianluca), Kawasaki, T. (Tomohiro), Sand, N.P. (Niels Peter), Jensen, J.M. (Jesper M.), Amano, T. (Tetsuya), Poon, M. (Michael), Altern Ovrehus, K. (Kristian), Sonck, J. (Jeroen), Rabbat, M. (Mark), Mullen, S. (Sarah), Bruyne, B. (Bernard) de, Rogers, C. (Campbell), Matsuo, H. (Hitoshi), Bax, J.J. (Jeroen), Leipsic, J. (Jonathon), Patel, M.R. (Manesh R.), Fairbairn, T.A. (Timothy A.), Nieman, K. (Koen), Akasaka, T. (Takashi), Nørgaard, B. (Bjarne), Berman, D.S. (Daniel), Raff, G.L. (Gilbert), Hurwitz-Koweek, L.M. (Lynne M.), Pontone, G. (Gianluca), Kawasaki, T. (Tomohiro), Sand, N.P. (Niels Peter), Jensen, J.M. (Jesper M.), Amano, T. (Tetsuya), Poon, M. (Michael), Altern Ovrehus, K. (Kristian), Sonck, J. (Jeroen), Rabbat, M. (Mark), Mullen, S. (Sarah), Bruyne, B. (Bernard) de, Rogers, C. (Campbell), Matsuo, H. (Hitoshi), Bax, J.J. (Jeroen), Leipsic, J. (Jonathon), and Patel, M.R. (Manesh R.)

Abstract

Methods and results: A total of 5083 patients with symptoms concerning for coronary artery disease (CAD) and atherosclerosis on CCTA were enrolled at 38 international sites from 15 July 2015 to 20 October 2017. Demographics, symptom status, CCTA and FFRCT findings, treatment plans, and 90 days outcomes were recorded. The primary endpoint of reclassification between core lab CCTA alone and CCTA plus FFRCT-based management plans occurred in 66.9% [confidence interval (CI): 64.8-67.6] of patients. Non-obstructive coronary disease was significantly lower in ICA patients with FFRCT ≤0.80 (14.4%) compared to patients with FFRCT >0.80 (43.8%, odds ratio 0.19, CI: 0.15-0.25, P < 0.001). In total, 72.3% of subjects undergoing ICA with FFRCT ≤0.80 were revascularized. No death/myocardial infarction (MI) occurred within 90 days in patients with FFRCT >0.80 (n = 1529), whereas 19 (0.6%) MACE [hazard ratio (HR) 19.75, CI: 1.19-326, P = 0.0008] and 14 (0.3%) death/MI (HR 14.68, CI 0.88-246, P = 0.039) occurred in subjects with an FFRCT ≤0.80.Conclusions: In a large international multicentre population, FFRCT modified treatment recommendation in two-thirds of subjects as compared to CCTA alone, was associated with less negative ICA, predicted revascularization, and identified subjects at low risk of adverse events through 90 days.Aims: Non-invasive assessment of stable chest pain patients is a critical determinant of resource utilization and clinical outcomes. Increasingly coronary computed tomography angiography (CCTA) with selective CCTA-derived fractional flow reserve (FFRCT) is being used. The ADVANCE Registry, is a large prospective examination of using a CCTA and FFRCT diagnostic pathway in real-world settings, with the aim of determining the impact of this pathway on decision-making, downstream invasive coronary angiography (ICA), revascularization, and major adverse cardiovascular events (MACE).

Published
2018
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39. Real-world clinical utility and impact on clinical decision-making of coronary computed tomography angiography-derived fractional flow reserve: lessons from the ADVANCE Registry

Author

Fairbairn, TA, Nieman, Koen, Akasaka, T, Norgaard, BL, Berman, DS, Raff, G, Hurwitz-Koweek, LM, Pontone, G, Kawasaki, T, Sand, NP, Jensen, JM, Amano, T, Poon, M, Ovrehus, K, Sonck, J, Rabbat, M, Mullen, S, de Bruyne, B, Rogers, C, Matsuo, H, Bax, JJ, Leipsic, J, Patel, MR, Fairbairn, TA, Nieman, Koen, Akasaka, T, Norgaard, BL, Berman, DS, Raff, G, Hurwitz-Koweek, LM, Pontone, G, Kawasaki, T, Sand, NP, Jensen, JM, Amano, T, Poon, M, Ovrehus, K, Sonck, J, Rabbat, M, Mullen, S, de Bruyne, B, Rogers, C, Matsuo, H, Bax, JJ, Leipsic, J, and Patel, MR

Published
2018

43. Spin-on metal oxide materials for N7 and beyond patterning applications

Author

Mannaert, G., additional, Altamirano-Sanchez, E., additional, Hopf, T., additional, Sebaai, F., additional, Lorant, C., additional, Petermann, C., additional, Hong, S.-E., additional, Mullen, S., additional, Wolfer, E., additional, Mckenzie, D., additional, Yao, H., additional, Rahman, D., additional, Cho, J.-Y., additional, Padmanaban, M., additional, and Piumi, D., additional

Published
2017
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45. Genome-wide linkage meta-analysis identifies susceptibility loci at 2q34 and 13q31.3 for genetic generalized epilepsies

Author

EPICURE Consortium, Leu C., de Kovel C. G., Zara F., Striano P., Pezzella M., Robbiano A., Bianchi A., Coppola A., Giallonardo A. T., Beccaria F., Trenité D. K., Lindhout D., Gaus V., Schmitz B., Janz D., Weber Y. G., Becker F., Lerche H., Kleefuss Lie A. A., Hallman K., Kunz W. S., Elger C. E., Muhle H., Stephani U., Møller R. S., Hjalgrim H., Mullen S., Scheffer I. E., Berkovic S. F., Everett K. V., Gardiner M. R., Marini C., Guerrini R., Lehesjoki A. E., Siren A., Nabbout R., Baulac S., Leguern E., Serratosa J. M., Rosenow F., Feucht M., Unterberger I., Covanis A., Suls A., Weckhuysen S., Kaneva R., Caglayan H., Turkdogan D., Baykan B., Bebek N., Ozbek U., Hempelmann A., Schulz H., Rüschendorf F., Trucks H., Nürnberg P., Avanzini G., Koeleman B. P., Sander T., BISULLI, FRANCESCA, TINUPER, PAOLO, YÜCESAN, EMRAH, EPICURE Consortium, Leu C., de Kovel C.G., Zara F., Striano P., Pezzella M., Robbiano A., Bianchi A., Bisulli F., Coppola A., Giallonardo A.T., Beccaria F., Trenité D.K., Lindhout D., Gaus V., Schmitz B., Janz D., Weber Y.G., Becker F., Lerche H., Kleefuss-Lie A.A., Hallman K., Kunz W.S., Elger C.E., Muhle H., Stephani U., Møller R.S., Hjalgrim H., Mullen S., Scheffer I.E., Berkovic S.F., Everett K.V., Gardiner M.R., Marini C., Guerrini R., Lehesjoki A.E., Siren A., Nabbout R., Baulac S., Leguern E., Serratosa J.M., Rosenow F., Feucht M., Unterberger I., Covanis A., Suls A., Weckhuysen S., Kaneva R., Caglayan H., Turkdogan D., Baykan B., Bebek N., Ozbek U., Hempelmann A., Schulz H., Rüschendorf F., Trucks H., Nürnberg P., Avanzini G., Koeleman B.P., Sander T., and Tinuper P.

Subjects
Male, Chromosomes, Human, Pair 13, Genotype, Genetic Linkage, Chromosome Mapping, complex inheritance, Pedigree, genetic generalized epilepsy, myoclonic seizure, Phenotype, Genetic Loci, Chromosomes, Human, Pair 2, Humans, Epilepsy, Generalized, Family, Female, Genetic Predisposition to Disease, linkage analysis, absence seizure, Genome-Wide Association Study
Abstract

PURPOSE: Genetic generalized epilepsies (GGEs) have a lifetime prevalence of 0.3% with heritability estimates of 80%. A considerable proportion of families with siblings affected by GGEs presumably display an oligogenic inheritance. The present genome-wide linkage meta-analysis aimed to map: (1) susceptibility loci shared by a broad spectrum of GGEs, and (2) seizure type-related genetic factors preferentially predisposing to either typical absence or myoclonic seizures, respectively. METHODS: Meta-analysis of three genome-wide linkage datasets was carried out in 379 GGE-multiplex families of European ancestry including 982 relatives with GGEs. To dissect out seizure type-related susceptibility genes, two family subgroups were stratified comprising 235 families with predominantly genetic absence epilepsies (GAEs) and 118 families with an aggregation of juvenile myoclonic epilepsy (JME). To map shared and seizure type-related susceptibility loci, both nonparametric loci (NPL) and parametric linkage analyses were performed for a broad trait model (GGEs) in the entire set of GGE-multiplex families and a narrow trait model (typical absence or myoclonic seizures) in the subgroups of JME and GAE families. KEY FINDINGS: For the entire set of 379 GGE-multiplex families, linkage analysis revealed six loci achieving suggestive evidence for linkage at 1p36.22, 3p14.2, 5q34, 13q12.12, 13q31.3, and 19q13.42. The linkage finding at 5q34 was consistently supported by both NPL and parametric linkage results across all three family groups. A genome-wide significant nonparametric logarithm of odds score of 3.43 was obtained at 2q34 in 118 JME families. Significant parametric linkage to 13q31.3 was found in 235 GAE families assuming recessive inheritance (heterogeneity logarithm of odds = 5.02). SIGNIFICANCE: Our linkage results support an oligogenic predisposition of familial GGE syndromes. The genetic risk factor at 5q34 confers risk to a broad spectrum of familial GGE syndromes, whereas susceptibility loci at 2q34 and 13q31.3 preferentially predispose to myoclonic seizures or absence seizures, respectively. Phenotype- genotype strategies applying narrow trait definitions in phenotypic homogeneous subgroups of families improve the prospects of disentangling the genetic basis of common familial GGE syndromes.

Published
2012

46. Genome-wide linkage meta-analysis identifies susceptibility loci at 2q34 and 13q31.3 for genetic generalized epilepsies

Author

Leu C, de Kovel CG, Zara F, Striano P, Pezzella M, Robbiano A, Bianchi A, Bisulli F, Coppola A, Giallonardo AT, Beccaria F, Trenité DK, Lindhout D, Gaus V, Schmitz B, Janz D, Weber YG, Becker F, Lerche H, Kleefuss Lie AA, Hallman K, Kunz WS, Elger CE, Muhle H, Stephani U, Møller RS, Hjalgrim H, Mullen S, Scheffer IE, Berkovic SF, Everett KV, Gardiner MR, Marini C, Guerrini R, Lehesjoki AE, Siren A, Nabbout R, Baulac S, Leguern E, Serratosa JM, Rosenow F, Feucht M, Unterberger I, Covanis A, Suls A, Weckhuysen S, Kaneva R, Caglayan H, Turkdogan D, Baykan B, Bebek N, Ozbek U, Hempelmann A, Schulz H, Rüschendorf F, Trucks H, Nürnberg P, Avanzini G, Koeleman BP, Sander T, EPICURE Consortium, COPPOLA, ANTONIETTA, DEL GIUDICE, ENNIO, Leu, C, de Kovel, Cg, Zara, F, Striano, P, Pezzella, M, Robbiano, A, Bianchi, A, Bisulli, F, Coppola, A, Giallonardo, At, Beccaria, F, Trenité, Dk, Lindhout, D, Gaus, V, Schmitz, B, Janz, D, Weber, Yg, Becker, F, Lerche, H, Kleefuss Lie, Aa, Hallman, K, Kunz, W, Elger, Ce, Muhle, H, Stephani, U, Møller, R, Hjalgrim, H, Mullen, S, Scheffer, Ie, Berkovic, Sf, Everett, Kv, Gardiner, Mr, Marini, C, Guerrini, R, Lehesjoki, Ae, Siren, A, Nabbout, R, Baulac, S, Leguern, E, Serratosa, Jm, Rosenow, F, Feucht, M, Unterberger, I, Covanis, A, Suls, A, Weckhuysen, S, Kaneva, R, Caglayan, H, Turkdogan, D, Baykan, B, Bebek, N, Ozbek, U, Hempelmann, A, Schulz, H, Rüschendorf, F, Trucks, H, Nürnberg, P, Avanzini, G, Koeleman, Bp, Sander, T, Epicure, Consortium, DEL GIUDICE, Ennio, and Coppola, Antonietta

Published
2012

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