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© 2015. Introduction: There is increasing evidence of cancer patients presenting to emergency departments (ED). The study aim was to analyse the characteristics of adult cancer patients presenting to one ED. Understanding cancer patient presentations could assist in the development of new models of care. Methods: A 12 month retrospective audit was conducted of a random sample of cancer patients. Demographics and characteristic variables were analysed using descriptive, comparative and correlational statistics. Results: The presentation rate for adult cancer patients was 1110 (2.4%) with 290 sampled. The common symptoms were fever (n = 54: 18.6%), abdominal pain (n = 34: 11.7%), and shortness of breath (. n = 32: 11%). The majority of patients were allocated a Triage Category 2 (n = 94: 32.4%) or Triage Category 3 (n = 131: 45.2%). The majority of patients presented between 2 and 15 times. For patients administered antibiotics the average time was 119.8 minutes (SD ± 85.5). The average ED length of stay was mean 8.08 hours with 271 patients (93.4%) admitted to the hospital. Of the 290 patients, 105 (36.2%) had died within 12 months of ED presentation. Conclusion: The study has shown that while cancer patients are only a small percentage of ED presentations the vast majority are allocated high triage codes, have high admission rates and high mortality rates.

Biomimetic scaffolds hold great promise for therapeutic repair of cartilage, but although most scaffolds are tested with cells in vitro, there are very few ex vivo models (EVMs) where adult cartilage and scaffolds are co-cultured to optimize their interaction prior to in vivo studies. This study describes a simple, non-compressive method that is applicable to mammalian or human cartilage and provides a reasonable throughput of samples. Rings of full-depth articular cartilage slices were derived from human donors undergoing knee replacement for osteoarthritis and a 3 mm core of a collagen/glycosaminoglycan biomimetic scaffold (Tigenix, UK) inserted to create the EVM. Adult osteoarthritis chondrocytes were seeded into the scaffold and cultures maintained for up to 30 days. Ex vivo models were stable throughout experiments, and cells remained viable. Chondrocytes seeded into the EVM attached throughout the scaffold and in contact with the cartilage explants. Cell migration and deposition of extracellular matrix proteins in the scaffold was enhanced by growth factors particularly if the scaffold was preloaded with growth factors. This study demonstrates that the EVM represents a suitable model that has potential for testing a range of therapeutic parameters such as numbers/types of cell, growth factors or therapeutic drugs before progressing to costly pre-clinical trials.

The aim of this study was to develop a hypothesis to explain the link between HIV prevalence and area of residence. The study was conducted in two parts using two existing data sources. In Part 1, the bloodborne viral test status and test results of a sample of clients attending treatment in December 2001 in two areas of Dublin, an inner city area (Dublin 8) and a suburban area (Dublin 24), were extracted from the Bloodborne Viral Status Dataset created by Grogan. In Part 2 the characteristics of heroin users seeking treatment for the first time at treatment services in their respective areas of residence, Dublin 8 or Dublin 24, between 1997 and 2000 were examined, using data from the National Drug Treatment Reporting System. A higher proportion of heroin users in Dublin 8 had HIV and hepatitis C than did their counterparts in Dublin 24. The analysis suggests that heroin users in Dublin 8 were more likely both to have ever used cocaine and to have used heroin daily, than were those who lived in Dublin 24. Also, a higher proportion of injectors living in Dublin 8 used heroin and cocaine concurrently than did their counterparts in Dublin 24. In both samples, heroin users who lived in Dublin 8 were older than those who lived in Dublin 24. The findings led to a hypothesis:'The risk of acquiring HIV is associated with area of residence and may be linked to cocaine use.