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2. Prognostic scores for ursodeoxycholic acid-treated patients predict graft loss and mortality in recurrent primary biliary cholangitis after liver transplantation

Author

Montano-Loza, Aldo J., Lytvyak, Ellina, Hirschfield, Gideon, Hansen, Bettina E., Ebadi, Maryam, Berney, Thierry, Toso, Christian, Magini, Giulia, Villamil, Alejandra, Nevens, Frederik, Van den Ende, Natalie, Pares, Albert, Ruiz, Pablo, Terrabuio, Débora, Trivedi, Palak J., Abbas, Nadir, Donato, Maria Francesca, Yu, Lei, Landis, Charles, Dumortier, Jérôme, Dyson, Jessica Katharine, van der Meer, Adriaan J., de Veer, Rozanne, Pedersen, Mark, Mayo, Marlyn, Manns, Michael P., Taubert, Richard, Kirchner, Theresa, Belli, Luca S., Mazzarelli, Chiara, Stirnimann, Guido, Floreani, Annarosa, Cazzagon, Nora, Russo, Francesco Paolo, Burra, Patrizia, Zigmound, Udi, Houri, Inbal, Carbone, Marco, Mulinacci, Giacomo, Fagiuoli, Stefano, Pratt, Daniel Stephan, Bonder, Alan, Schiano, Thomas D., Haydel, Brandy, Lohse, Ansgar, Schramm, Christoph, Rüther, Darius, Casu, Stefania, Verhelst, Xavier, Beretta-Piccoli, Benedetta Terziroli, Robles, Mercedes, Mason, Andrew L., and Corpechot, Christophe

Published
2024
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4. A quantitative MRCP-derived score for medium-term outcome prediction in primary sclerosing cholangitis

Author

Cristoferi, Laura, Porta, Marco, Bernasconi, Davide Paolo, Leonardi, Filippo, Gerussi, Alessio, Mulinacci, Giacomo, Palermo, Andrea, Gallo, Camilla, Scaravaglio, Miki, Stucchi, Eliana, Maino, Cesare, Ippolito, Davide, D'Amato, Daphne, Ferreira, Carlos, Nardi, Alessandra, Banerjee, Rajarshi, Valsecchi, Maria Grazia, Antolini, Laura, Corso, Rocco, Sironi, Sandro, Fagiuoli, Stefano, Invernizzi, Pietro, and Carbone, Marco

Published
2023
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5. Study Typology: An Overview

Author

Mulinacci, Giacomo, Carbone, Marco, Coccolini, Federico, Series Editor, Coimbra, Raul, Series Editor, Kirkpatrick, Andrew W., Series Editor, Di Saverio, Salomone, Series Editor, Ansaloni, Luca, Editorial Board Member, Balogh, Zsolt, Editorial Board Member, Biffl, Walt, Editorial Board Member, Catena, Fausto, Editorial Board Member, Davis, Kimberly, Editorial Board Member, Ferrada, Paula, Editorial Board Member, Fraga, Gustavo, Editorial Board Member, Ivatury, Rao, Editorial Board Member, Kluger, Yoram, Editorial Board Member, Leppaniemi, Ari, Editorial Board Member, Maier, Ron, Editorial Board Member, Moore, Ernest E., Editorial Board Member, Napolitano, Lena, Editorial Board Member, Peitzman, Andrew, Editorial Board Member, Reilly, Patrick, Editorial Board Member, Rizoli, Sandro, Editorial Board Member, Sakakushev, Boris E., Editorial Board Member, Sartelli, Massimo, Editorial Board Member, Scalea, Thomas, Editorial Board Member, Spain, David, Editorial Board Member, Stahel, Philip, Editorial Board Member, Sugrue, Michael, Editorial Board Member, Velmahos, George, Editorial Board Member, Weber, Dieter, Editorial Board Member, Ceresoli, Marco, editor, Abu-Zidan, Fikri M., editor, and Staudenmayer, Kristan L., editor

Published
2022
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6. Reduced humoral response to two doses of COVID-19 vaccine in patients with inflammatory bowel disease: Data from ESCAPE-IBD, an IG-IBD study

Author

Amato, Arnaldo, Ascolani, Marta, Calabrese, Giulio, Casà, Angelo, Comberlato, Michele, Conforti, Francesco Simone, De Bona, Manuela, Demarzo, Maria Giulia, Doldo, Patrizia, Dragoni, Gabriele, Furfaro, Federica, Mulinacci, Giacomo, Olmo, Oriana, O'Sed, Nicole Piazza, Paba, Salvatore, Radice, Simona, Renna, Sara, Ribaldone, Davide Giuseppe, Rizzuto, Giulia, Macaluso, Fabio Salvatore, Principi, Mariabeatrice, Facciotti, Federica, Contaldo, Antonella, Todeschini, Alessia, Saibeni, Simone, Bezzio, Cristina, Castiglione, Fabiana, Nardone, Olga Maria, Spagnuolo, Rocco, Fantini, Massimo Claudio, Riguccio, Gaia, Caprioli, Flavio, Viganò, Chiara, Felice, Carla, Fiorino, Gionata, Correale, Carmen, Bodini, Giorgia, Milla, Monica, Scardino, Giulia, Vernero, Marta, Desideri, Federico, Mannino, Mariella, Rizzo, Giuseppe, and Orlando, Ambrogio

Published
2023
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7. Sarcopenia as a Predictor of Mortality in a Cohort of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography.

Author

Mulinacci, Giacomo, Conti, Clara Benedetta, Savino, Alberto, Gandola, Davide, Ippolito, Davide, Frego, Roberto, Redaelli, Alessandro Ettore, Maino, Marta, and Dinelli, Marco Emilio

Subjects
*ENDOSCOPIC retrograde cholangiopancreatography, *OLDER patients, *SARCOPENIA, *COMPUTED tomography, *SKELETAL muscle
Abstract

Background and aims: Despite technical advances, endoscopic retrograde cholangiopancreatography (ERCP) is associated with complications and potentially lethal outcomes. Sarcopenia, a complex syndrome mainly associated with aging, has been recognized as a predictor of poor surgical outcomes. Thus far, the impact of sarcopenia on ERCP remains unknown. The present study evaluates the role of sarcopenia as a predictor of ERCP-related outcomes in a cohort of elderly patients. Methods: Patients who underwent ERCP between June 2019 and January 2023 were retrospectively included. Demographic and procedure-associated data were collected. Sarcopenia was assessed using the skeletal muscle index (SMI) measured from a single axial slice through the L3 vertebra on a CT scan. ERCP-related outcomes were recorded. Univariate and multivariate analyses were used to assess the correlation between sarcopenia and procedural outcomes. Results: In total, 256 patients were enrolled, of whom 30 (11.7%) were sarcopenic. Cardiopulmonary complications of ERCP occurred in 3.5%. Sarcopenia was associated with higher 30-day and 12-month post-ERCP mortality (OR 3.45, p = 0.03; OR 3.87, p = 0.004) and longer hospitalization time (7 vs. 11 days, p = 0.003). Conclusions: SMI is an easy and objective index of sarcopenia that could be used to predict ERCP outcomes. Indeed, sarcopenia was independently associated with prolonged hospitalization and increased mortality in a retrospective cohort of elderly patients. [ABSTRACT FROM AUTHOR]

Published
2025
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8. Real-world experience with obeticholic acid in patients with primary biliary cholangitis

Author

D’Amato, Daphne, De Vincentis, Antonio, Malinverno, Federica, Viganò, Mauro, Alvaro, Domenico, Pompili, Maurizio, Picciotto, Antonino, Palitti, Valeria Pace, Russello, Maurizio, Storato, Silvia, Pigozzi, Marie Graciella, Calvaruso, Vincenza, De Gasperi, Elisabetta, Lleo, Ana, Castellaneta, Antonino, Pellicelli, Adriano, Cazzagon, Nora, Floreani, Annarosa, Muratori, Luigi, Fagiuoli, Stefano, Niro, Grazia Anna, Feletti, Valentina, Cozzolongo, Raffaele, Terreni, Natalia, Marzioni, Marco, Pellicano, Rinaldo, Pozzoni, Pietro, Baiocchi, Leonardo, Chessa, Luchino, Rosina, Floriano, Bertino, Gaetano, Vinci, Maria, Morgando, Anna, Vanni, Ester, Scifo, Gaetano, Sacco, Rodolfo, D’Antò, Maria, Bellia, Valentina, Boldizzoni, Roberto, Casella, Silvia, Omazzi, Barbara, Poggi, Guido, Cristoferi, Laura, Gerussi, Alessio, Ronca, Vincenzo, Venere, Rosanna, Ponziani, Francesca, Cannavò, Maria, Mussetto, Alessandro, Fontana, Rosanna, Losito, Francesco, Frazzetto, Evelise, Distefano, Marco, Colapietro, Francesca, Labanca, Sara, Marconi, Giulia, Grassi, Giuseppe, Galati, Giovanni, O’Donnell, Sarah Elizabeth, Mancuso, Clara, Mulinacci, Giacomo, Palermo, Andrea, Claar, Ernesto, Izzi, Antonio, Picardi, Antonio, Invernizzi, Pietro, Carbone, Marco, and Vespasiani-Gentilucci, Umberto

Published
2021
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10. Helmet CPAP to treat hypoxic pneumonia outside the ICU: an observational study during the COVID-19 outbreak

Author

Coppadoro, Andrea, Benini, Annalisa, Fruscio, Robert, Verga, Luisa, Mazzola, Paolo, Bellelli, Giuseppe, Carbone, Marco, Mulinacci, Giacomo, Soria, Alessandro, Noè, Beatrice, Beck, Eduardo, Di Sciacca, Riccardo, Ippolito, Davide, Citerio, Giuseppe, Valsecchi, Maria Grazia, Biondi, Andrea, Pesci, Alberto, Bonfanti, Paolo, Gaudesi, Davide, Bellani, Giacomo, and Foti, Giuseppe

Published
2021
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11. Prevalence of Disease-Related Malnutrition and Micronutrients Deficit in Patients with Inflammatory Bowel Disease: A Multicentric Cross-Sectional Study by the GSMII (Inflammatory Bowel Disease Study Group).

Author

Viganò, Chiara, Palermo, Andrea, Mulinacci, Giacomo, Pirola, Lorena, Losco, Alessandra, Meucci, Gianmichele, Saibeni, Simone, Pastorelli, Luca, Amato, Arnaldo, Gatti, Mario, Cortelezzi, Claudio, Sabatino, Antonio Di, Morganti, Daniela, Boni, Francesca, Grasso, Gianalberto, Casella, Giovanni, Casini, Valentina, Caprioli, Flavio Andrea, Vecchi, Maurizio, and Bezzio, Cristina

Published
2024
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13. Prevalence of Disease-Related Malnutrition and Micronutrients Deficit in Patients with Inflammatory Bowel Disease: A Multicentric Cross-Sectional Study by the GSMII (Inflammatory Bowel Disease Study Group)

Author

Viganò, Chiara, primary, Palermo, Andrea, additional, Mulinacci, Giacomo, additional, Pirola, Lorena, additional, Losco, Alessandra, additional, Meucci, Gianmichele, additional, Saibeni, Simone, additional, Pastorelli, Luca, additional, Amato, Arnaldo, additional, Gatti, Mario, additional, Cortelezzi, Claudio, additional, Di Sabatino, Antonio, additional, Morganti, Daniela, additional, Boni, Francesca, additional, Grasso, Gianalberto, additional, Casella, Giovanni, additional, Casini, Valentina, additional, Caprioli, Flavio Andrea, additional, Vecchi, Maurizio, additional, Bezzio, Cristina, additional, Bergna, Irene, additional, Radaelli, Franco, additional, Mengoli, Caterina, additional, and Massironi, Sara, additional

Published
2023
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16. A quantitative MRCP-derived score for medium-term outcome prediction in primary sclerosing cholangitis

Author

Cristoferi, L, Porta, M, Bernasconi, D, Leonardi, F, Gerussi, A, Mulinacci, G, Palermo, A, Gallo, C, Scaravaglio, M, Stucchi, E, Maino, C, Ippolito, D, D'Amato, D, Ferreira, C, Nardi, A, Banerjee, R, Valsecchi, M, Antolini, L, Corso, R, Sironi, S, Fagiuoli, S, Invernizzi, P, Carbone, M, Cristoferi, Laura, Porta, Marco, Bernasconi, Davide Paolo, Leonardi, Filippo, Gerussi, Alessio, Mulinacci, Giacomo, Palermo, Andrea, Gallo, Camilla, Scaravaglio, Miki, Stucchi, Eliana, Maino, Cesare, Ippolito, Davide, D'Amato, Daphne, Ferreira, Carlos, Nardi, Alessandra, Banerjee, Rajarshi, Valsecchi, Maria Grazia, Antolini, Laura, Corso, Rocco, Sironi, Sandro, Fagiuoli, Stefano, Invernizzi, Pietro, Carbone, Marco, Cristoferi, L, Porta, M, Bernasconi, D, Leonardi, F, Gerussi, A, Mulinacci, G, Palermo, A, Gallo, C, Scaravaglio, M, Stucchi, E, Maino, C, Ippolito, D, D'Amato, D, Ferreira, C, Nardi, A, Banerjee, R, Valsecchi, M, Antolini, L, Corso, R, Sironi, S, Fagiuoli, S, Invernizzi, P, Carbone, M, Cristoferi, Laura, Porta, Marco, Bernasconi, Davide Paolo, Leonardi, Filippo, Gerussi, Alessio, Mulinacci, Giacomo, Palermo, Andrea, Gallo, Camilla, Scaravaglio, Miki, Stucchi, Eliana, Maino, Cesare, Ippolito, Davide, D'Amato, Daphne, Ferreira, Carlos, Nardi, Alessandra, Banerjee, Rajarshi, Valsecchi, Maria Grazia, Antolini, Laura, Corso, Rocco, Sironi, Sandro, Fagiuoli, Stefano, Invernizzi, Pietro, and Carbone, Marco

Abstract

Background: Magnetic resonance cholangiopancreatography (MRCP) is the gold standard for diagnosis of patients with primary sclerosing cholangitis (PSC). The semi-quantitative MRCP-derived Anali scores proposed for risk stratification, have poor-to-moderate inter-reader agreement. Aims: To evaluate the prognostic performance of quantitative MRCP metrics in PSC. Methods: This is a retrospective study of PSC patients undergoing MRCP. Images were processed using MRCP+ software (Perspectum Ltd, Oxford) that provides quantitative biliary features, semi-automatically extracted by artificial intelligence-driven analysis of MRCP-3D images. The prognostic value of biliary features has been assessed for all hepato-biliary complications. Results: 87 PSC patients have been included in the analysis. Median follow-up from MRCP to event/censoring of 30.9 months (Q1-Q3=13.6–46.6). An adverse outcome occurred in 27 (31.0%) patients. The number of biliary strictures (HR=1.05 per unit, 95%CI 1.02–1.08, p < 0.0001), spleen length (HR=1.16 per cm, 95%CI 1.01–1.34, p = 0.039), adjusted for height, age at MRCP, and time from diagnosis to MRCP predicted higher risk of hepatobiliary complications. These were incorporated into a the quantitative MRCP-derived PSC (qMRCP-PSC) score (C-statistic=0.80). After 3-fold cross-validation, qMRCP-PSC outperformed the Anali score in our cohort (C-statistic of 0.78 vs 0.64) and enabled the discrimination of survival of PSC patients (log-rank p < 0.0001). Conclusions: The qMRCP-PSC score identified patients at higher risk of hepatobiliary complications and outperformed the available radiological scores. It represents a novel quantitative biomarker for disease monitoring and a potential surrogate endpoint for clinical trials.

Published
2023

17. Risk stratification in primary sclerosing cholangitis

Author

Mulinacci, G, Cristoferi, L, Palermo, A, Lucà, M, Gerussi, A, Invernizzi, P, Carbone, M, Mulinacci, Giacomo, Cristoferi, Laura, Palermo, Andrea, Lucà, Martina, Gerussi, Alessio, Invernizzi, Pietro, Carbone, Marco, Mulinacci, G, Cristoferi, L, Palermo, A, Lucà, M, Gerussi, A, Invernizzi, P, Carbone, M, Mulinacci, Giacomo, Cristoferi, Laura, Palermo, Andrea, Lucà, Martina, Gerussi, Alessio, Invernizzi, Pietro, and Carbone, Marco

Abstract

Primary sclerosing cholangitis (PSC) is a chronic liver disorder commonly affecting young patients and associated with uncertain prognosis and elevated risk of end-stage liver disease and hepatobiliary cancer. Rate of progression in PSC is heterogeneous and accurately predicting the disease course is of paramount importance to clinical practice and interventional trial design. So far, efforts have brought to the development of models looking at short-to-middle-term outcome using composite models including clinical, laboratory, radiological and histological parameters with limited performance. In the era of whole genome sequencing and digital innovation, the time is ripe for the development of stratified medicine in PSC. Efforts should be directed toward developing well-phenotyped cohorts of patients with longitudinal follow-up across sustained periods of time, application of novel image-processing technology, and biomarker discovery using multiomics platforms.

Published
2023

18. Eosinophilic esophagitis: does age matter?

Author

Massironi, Sara, Elvevi, Alessandra, Panceri, Roberto, Mulinacci, Giacomo, Colella, Giacomo, Biondi, Andrea, Invernizzi, Pietro, Danese, Silvio, and Vespa, Edoardo

Subjects
ESOPHAGUS diseases, CHILD patients, AGE groups, GROWTH of children, SYMPTOMS, EOSINOPHILIC esophagitis
Abstract

Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus with increasing prevalence worldwide. It is a multifactorial disease caused by a combination of immunologic, genetic, and environmental factors. The clinical presentation of EoE varies largely, especially between different age groups. While diagnostic criteria and therapeutic goals are similar in children and adults, there are differences in treatment, with a more cautious approach in children to avoid growth disturbances. In addition, close monitoring and follow-up are essential in children to ensure uninterrupted growth. A search in PubMed/MEDLINE, EMBASE, and SCOPUS databases was conducted to identify relevant studies published between January 2010 and January 2023 to give an overview of the state-of-the-art of EoE epidemiology, diagnosis, and treatment while focusing on similarities and differences between the adult and the pediatric population. The current state of research indicates that while significant progress has been made in understanding and treating EoE, further research and advances are needed to optimize diagnostic strategies, tailored treatment approaches, monitoring, and follow-up, and improve long-term outcomes for patients. With further innovation, the management of EoE can become more precise and tailored, leading to better patient outcomes and improved quality of life. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Reduced humoral response to two doses of COVID-19 vaccine in patients with inflammatory bowel disease: Data from ESCAPE-IBD, an IG-IBD study

Author

Macaluso, Fabio Salvatore, primary, Principi, Mariabeatrice, additional, Facciotti, Federica, additional, Contaldo, Antonella, additional, Todeschini, Alessia, additional, Saibeni, Simone, additional, Bezzio, Cristina, additional, Castiglione, Fabiana, additional, Nardone, Olga Maria, additional, Spagnuolo, Rocco, additional, Fantini, Massimo Claudio, additional, Riguccio, Gaia, additional, Caprioli, Flavio, additional, Viganò, Chiara, additional, Felice, Carla, additional, Fiorino, Gionata, additional, Correale, Carmen, additional, Bodini, Giorgia, additional, Milla, Monica, additional, Scardino, Giulia, additional, Vernero, Marta, additional, Desideri, Federico, additional, Mannino, Mariella, additional, Rizzo, Giuseppe, additional, Orlando, Ambrogio, additional, Amato, Arnaldo, additional, Ascolani, Marta, additional, Calabrese, Giulio, additional, Casà, Angelo, additional, Comberlato, Michele, additional, Conforti, Francesco Simone, additional, De Bona, Manuela, additional, Demarzo, Maria Giulia, additional, Doldo, Patrizia, additional, Dragoni, Gabriele, additional, Furfaro, Federica, additional, Mulinacci, Giacomo, additional, Olmo, Oriana, additional, O'Sed, Nicole Piazza, additional, Paba, Salvatore, additional, Radice, Simona, additional, Renna, Sara, additional, Ribaldone, Davide Giuseppe, additional, and Rizzuto, Giulia, additional

Published
2023
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24. New insights on the role of human leukocyte antigen complex in primary biliary cholangitis

Author

Mulinacci, Giacomo, Palermo, Andrea, Gerussi, Alessio, Asselta, Rosanna, Gershwin, Merrill Eric, Invernizzi, Pietro, Mulinacci, G, Palermo, A, Gerussi, A, Asselta, R, Gershwin, M, and Invernizzi, P

Subjects
HLA haplotype, HLA Antigens, Liver Cirrhosis, Biliary, human leukocyte antigens complex, Immunology, Humans, Immunology and Allergy, Genetic Predisposition to Disease, genetic, primary biliary cholangiti, immunotolerance, Genome-Wide Association Study
Abstract

Primary Biliary Cholangitis (PBC) is a rare autoimmune cholangiopathy. Genetic studies have shown that the strongest statistical association with PBC has been mapped in the human leukocyte antigen (HLA) locus, a highly polymorphic area that mostly contribute to the genetic variance of the disease. Furthermore, PBC presents high variability throughout different population groups, which may explain the different geoepidemiology of the disease. A major role in defining HLA genetic contribution has been given by genome-wide association studies (GWAS) studies; more recently, new technologies have been developed to allow a deeper understanding. The study of the altered peptides transcribed by genetic alterations also allowed the development of novel therapeutic strategies in the context of immunotolerance. This review summarizes what is known about the immunogenetics of PBC with a focus on the HLA locus, the different distribution of HLA alleles worldwide, and how HLA modifications are associated with the pathogenesis of PBC. Novel therapeutic strategies are also outlined.

Published
2022
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26. Radiomics-based model for outcome prediction in primary sclerosing cholangitis

Author

Cristoferi, Laura, primary, Porta, Marco, additional, Bernasconi, Davide, additional, Filippo, Leonardi, additional, Mulinacci, Giacomo, additional, Palermo, Andrea, additional, Gerussi, Alessio, additional, Scaravaglio, Miki, additional, Gallo, Camilla, additional, Stucchi, Eliana, additional, Maino, Cesare, additional, Ippolito, Davide, additional, D’Amato, Daphne, additional, Ferreira, Carlos, additional, Mavar-Haramija, Marija, additional, Banerjee, Rajarshi, additional, Antolini, Laura, additional, Valsecchi, Maria Grazie, additional, Fagiuoli, Stefano, additional, Invernizzi, Pietro, additional, and Carbone, Marco, additional

Published
2022
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27. EP1211: RADIOMICS-BASED MODEL FOR OUTCOME PREDICTION IN PRIMARY SCLEROSING CHOLANGITIS

Author

Cristoferi, Laura, primary, Porta, Marco, additional, Bernasconi, Davide Paolo, additional, Leonardi, Filippo, additional, Mulinacci, Giacomo, additional, Palermo, Andrea, additional, Gerussi, Alessio, additional, Gallo, Camilla, additional, Scaravaglio, Miki, additional, Stucchi, Eliana, additional, Maino, Cesare, additional, Ippolito, Davide, additional, D'Amato, Daphne, additional, Ferreira, Carlos, additional, Mavar, Marija, additional, Banerjee, Rajarshi, additional, Antolini, Laura, additional, Valsecchi, Maria Grazia, additional, Fagiuoli, Stefano, additional, Invernizzi, Pietro, additional, and Carbone, Marco, additional

Published
2022
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32. Additional file 1 of Helmet CPAP to treat hypoxic pneumonia outside the ICU: an observational study during the COVID-19 outbreak

Author

Coppadoro, Andrea, Benini, Annalisa, Fruscio, Robert, Verga, Luisa, Mazzola, Paolo, Bellelli, Giuseppe, Carbone, Marco, Mulinacci, Giacomo, Soria, Alessandro, Noè, Beatrice, Beck, Eduardo, Sciacca, Riccardo Di, Ippolito, Davide, Citerio, Giuseppe, Valsecchi, Maria Grazia, Biondi, Andrea, Pesci, Alberto, Bonfanti, Paolo, Gaudesi, Davide, Bellani, Giacomo, and Foti, Giuseppe

Subjects
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Abstract

Additional file 1. A PDF (portable document format) file containing two figures (e-Figure 1, 2) and three tables (e-Table 1, 2 and 3).

Published
2021
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34. Accuracy of Transient Elastography in assessing fibrosis at diagnosis in naïve patients with Primary Biliary Cholangitis: a dual cut-off approach

Author

Cristoferi, L, Calvaruso, V, Overi, D, Viganò, M, Rigamonti, C, Degasperi, E, Cardinale, V, Labanca, S, Zucchini, N, Fichera, A, Di Marco, V, Leutner, M, Venere, R, Picciotto, A, Lucà, M, Mulinacci, G, Palermo, A, Gerussi, A, D'Amato, D, O'Donnell, S, Cerini, F, De Benedittis, C, Malinverno, F, Ronca, V, Mancuso, C, Cazzagon, N, Ciaccio, A, Barisani, D, Marzioni, M, Floreani, A, Alvaro, D, Gaudio, E, Invernizzi, P, Carpino, G, Nardi, A, Carbone, M, Cristoferi, Laura, Calvaruso, Vincenza, Overi, Diletta, Viganò, Mauro, Rigamonti, Cristina, Degasperi, Elisabetta, Cardinale, Vincenzo, Labanca, Sara, Zucchini, Nicola, Fichera, Anna, Di Marco, Vito, Leutner, Monica, Venere, Rosanna, Picciotto, Antonino, Lucà, Martina, Mulinacci, Giacomo, Palermo, Andrea, Gerussi, Alessio, D'Amato, Daphne, O'Donnell, Sarah Elisabeth, Cerini, Federica, De Benedittis, Carla, Malinverno, Federica, Ronca, Vincenzo, Mancuso, Clara, Cazzagon, Nora, Ciaccio, Antonio, Barisani, Donatella, Marzioni, Marco, Floreani, Annarosa, Alvaro, Domenico, Gaudio, Eugenio, Invernizzi, Pietro, Carpino, Guido, Nardi, Alessandra, Carbone, Marco, Cristoferi, L, Calvaruso, V, Overi, D, Viganò, M, Rigamonti, C, Degasperi, E, Cardinale, V, Labanca, S, Zucchini, N, Fichera, A, Di Marco, V, Leutner, M, Venere, R, Picciotto, A, Lucà, M, Mulinacci, G, Palermo, A, Gerussi, A, D'Amato, D, O'Donnell, S, Cerini, F, De Benedittis, C, Malinverno, F, Ronca, V, Mancuso, C, Cazzagon, N, Ciaccio, A, Barisani, D, Marzioni, M, Floreani, A, Alvaro, D, Gaudio, E, Invernizzi, P, Carpino, G, Nardi, A, Carbone, M, Cristoferi, Laura, Calvaruso, Vincenza, Overi, Diletta, Viganò, Mauro, Rigamonti, Cristina, Degasperi, Elisabetta, Cardinale, Vincenzo, Labanca, Sara, Zucchini, Nicola, Fichera, Anna, Di Marco, Vito, Leutner, Monica, Venere, Rosanna, Picciotto, Antonino, Lucà, Martina, Mulinacci, Giacomo, Palermo, Andrea, Gerussi, Alessio, D'Amato, Daphne, O'Donnell, Sarah Elisabeth, Cerini, Federica, De Benedittis, Carla, Malinverno, Federica, Ronca, Vincenzo, Mancuso, Clara, Cazzagon, Nora, Ciaccio, Antonio, Barisani, Donatella, Marzioni, Marco, Floreani, Annarosa, Alvaro, Domenico, Gaudio, Eugenio, Invernizzi, Pietro, Carpino, Guido, Nardi, Alessandra, and Carbone, Marco

Abstract

Background and Aims: Liver fibrosis holds a relevant prognostic meaning in primary biliary cholangitis (PBC). Noninvasive fibrosis evaluation using vibration-controlled transient elastography (VCTE) is routinely performed. However, there is limited evidence on its accuracy at diagnosis in PBC. We aimed to estimate the diagnostic accuracy of VCTE in assessing advanced fibrosis (AF) at disease presentation in PBC. Approach and Results: We collected data from 167 consecutive treatment-naïve PBC patients who underwent liver biopsy (LB) at diagnosis at six Italian centers. VCTE examinations were completed within 12 weeks of LB. Biopsies were scored by two blinded expert pathologists, according to the Ludwig system. Diagnostic accuracy was estimated using the area under the receiver operating characteristic curves (AUROCs) for AF (Ludwig stage ≥III). Effects of biochemical and clinical parameters on liver stiffness measurement (LSM) were appraised. The derivation cohort consisted of 126 patients with valid LSM and LB; VCTE identified patients with AF with an AUROC of 0.89. LSM cutoffs ≤6.5 and >11.0 kPa enabled to exclude and confirm, respectively, AF (negative predictive value [NPV] = 0.94; positive predictive value [PPV] = 0.89; error rate = 5.6%). These values were externally validated in an independent cohort of 91 PBC patients (NPV = 0.93; PPV = 0.89; error rate = 8.6%). Multivariable analysis found that the only parameter affecting LSM was fibrosis stage. No association was found with BMI and liver biochemistry. Conclusions: In a multicenter study of treatment-naïve PBC patients, we identified two cutoffs (LSM ≤6.5 and >11.0 kPa) able to discriminate at diagnosis the absence or presence, respectively, of AF in PBC patients, with external validation. In patients with LSM between these two cutoffs, VCTE is not reliable and liver biopsy should be evaluated for accurate disease staging. BMI and liver biochemistry did not affect LSMs.

Published
2021

35. Helmet CPAP to treat hypoxic pneumonia outside the ICU: an observational study during the COVID-19 outbreak

Author

Coppadoro, A, Benini, A, Fruscio, R, Verga, L, Mazzola, P, Bellelli, G, Carbone, M, Mulinacci, G, Soria, A, Noè, B, Beck, E, Di Sciacca, R, Ippolito, D, Citerio, G, Valsecchi, M, Biondi, A, Pesci, A, Bonfanti, P, Gaudesi, D, Bellani, G, Foti, G, Coppadoro, Andrea, Benini, Annalisa, Fruscio, Robert, Verga, Luisa, Mazzola, Paolo, Bellelli, Giuseppe, Carbone, Marco, Mulinacci, Giacomo, Soria, Alessandro, Noè, Beatrice, Beck, Eduardo, Di Sciacca, Riccardo, Ippolito, Davide, Citerio, Giuseppe, Valsecchi, Maria Grazia, Biondi, Andrea, Pesci, Alberto, Bonfanti, Paolo, Gaudesi, Davide, Bellani, Giacomo, Foti, Giuseppe, Coppadoro, A, Benini, A, Fruscio, R, Verga, L, Mazzola, P, Bellelli, G, Carbone, M, Mulinacci, G, Soria, A, Noè, B, Beck, E, Di Sciacca, R, Ippolito, D, Citerio, G, Valsecchi, M, Biondi, A, Pesci, A, Bonfanti, P, Gaudesi, D, Bellani, G, Foti, G, Coppadoro, Andrea, Benini, Annalisa, Fruscio, Robert, Verga, Luisa, Mazzola, Paolo, Bellelli, Giuseppe, Carbone, Marco, Mulinacci, Giacomo, Soria, Alessandro, Noè, Beatrice, Beck, Eduardo, Di Sciacca, Riccardo, Ippolito, Davide, Citerio, Giuseppe, Valsecchi, Maria Grazia, Biondi, Andrea, Pesci, Alberto, Bonfanti, Paolo, Gaudesi, Davide, Bellani, Giacomo, and Foti, Giuseppe

Abstract

Respiratory failure due to COVID-19 pneumonia is associated with high mortality and may overwhelm health care systems, due to the surge of patients requiring advanced respiratory support. Shortage of intensive care unit (ICU) beds required many patients to be treated outside the ICU despite severe gas exchange impairment. Helmet is an effective interface to provide continuous positive airway pressure (CPAP) noninvasively. We report data about the usefulness of helmet CPAP during pandemic, either as treatment, a bridge to intubation or a rescue therapy for patients with care limitations (DNI).

Published
2021

37. Helmet CPAP to treat hypoxic pneumonia outside the ICU: an observational study during the COVID-19 outbreak

Author

Coppadoro, Andrea, primary, Benini, Annalisa, additional, Fruscio, Robert, additional, Verga, Luisa, additional, Mazzola, Paolo, additional, Bellelli, Giuseppe, additional, Carbone, Marco, additional, Mulinacci, Giacomo, additional, Soria, Alessandro, additional, Noe', Beatrice, additional, Beck, Eduardo, additional, Sciacca, Riccardo Di, additional, Ippolito, Davide, additional, Citerio, Giuseppe, additional, Valsecchi, Grazia, additional, Biondi, Andrea, additional, Pesci, Alberto, additional, Bonfanti, Paolo, additional, Gaudesi, Davide, additional, Bellani, Giacomo, additional, and Foti, Giuseppe, additional

Published
2021
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39. Helmet CPAP&nbsp;to Treat Hypoxic Pneumonia Outside the ICU: An Observational Study During the COVID-19 Outbreak

Author

Coppadoro, Andrea, primary, Benini, Annalisa, additional, Fruscio, Robert, additional, Verga, Luisa, additional, Mazzola, Paolo, additional, Carbone, Marco, additional, Mulinacci, Giacomo, additional, Soria, Alessandro, additional, Noe', Beatrice, additional, Beck, Eduardo, additional, Sciacca, Riccardo Di, additional, Ippolito, Davide, additional, Citerio, Giuseppe, additional, Valsecchi, Grazia, additional, Biondi, Andrea, additional, Pesci, Alberto, additional, Bonfanti, Paolo, additional, Gaudesi, Davide, additional, Bellani, Giacomo, additional, and Foti, Giuseppe, additional

Published
2020
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40. OS136 - Radiomics-based model for outcome prediction in primary sclerosing cholangitis

Author

Cristoferi, Laura, Porta, Marco, Bernasconi, Davide, Filippo, Leonardi, Mulinacci, Giacomo, Palermo, Andrea, Gerussi, Alessio, Scaravaglio, Miki, Gallo, Camilla, Stucchi, Eliana, Maino, Cesare, Ippolito, Davide, D’Amato, Daphne, Ferreira, Carlos, Mavar-Haramija, Marija, Banerjee, Rajarshi, Antolini, Laura, Valsecchi, Maria Grazie, Fagiuoli, Stefano, Invernizzi, Pietro, and Carbone, Marco

Published
2022
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41. Accuracy of Transient Elastography in Assessing Fibrosis at Diagnosis in Naïve Patients With Primary Biliary Cholangitis: A Dual Cut‐Off Approach.

Author

Cristoferi, Laura, Calvaruso, Vincenza, Overi, Diletta, Viganò, Mauro, Rigamonti, Cristina, Degasperi, Elisabetta, Cardinale, Vincenzo, Labanca, Sara, Zucchini, Nicola, Fichera, Anna, Di Marco, Vito, Leutner, Monica, Venere, Rosanna, Picciotto, Antonino, Lucà, Martina, Mulinacci, Giacomo, Palermo, Andrea, Gerussi, Alessio, D'Amato, Daphne, and Elisabeth O'Donnell, Sarah

Published
2021
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42. Multimodal Imaging Assessment of Vascular and Neurodegenerative Retinal Alterations in Type 1 Diabetic Patients without Fundoscopic Signs of Diabetic Retinopathy

Author

Sacconi, Riccardo, primary, Casaluci, Marco, additional, Borrelli, Enrico, additional, Mulinacci, Giacomo, additional, Lamanna, Francesca, additional, Gelormini, Francesco, additional, Carnevali, Adriano, additional, Querques, Lea, additional, Zerbini, Gianpaolo, additional, Bandello, Francesco, additional, and Querques, Giuseppe, additional

Published
2019
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44. Multimodal Imaging Assessment of Vascular and Neurodegenerative Retinal Alterations in Type 1 Diabetic Patients without Fundoscopic Signs of Diabetic Retinopathy

Author

Riccardo Sacconi, Francesco Gelormini, Enrico Borrelli, Lea Querques, Gianpaolo Zerbini, Francesco Bandello, Giacomo Mulinacci, Adriano Carnevali, Francesca Lamanna, Marco Casaluci, Giuseppe Querques, Sacconi, Riccardo, Casaluci, Marco, Borrelli, Enrico, Mulinacci, Giacomo, Lamanna, Francesca, Gelormini, Francesco, Carnevali, Adriano, Querques, Lea, Zerbini, Gianpaolo, Bandello, Francesco, and Querques, Giuseppe

Subjects
medicine.medical_specialty, Visual acuity, endocrine system diseases, genetic structures, Nerve fiber layer, lcsh:Medicine, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, dynamic vessel analyzer, Diabetes mellitus, Ophthalmology, medicine, Retina, optical coherence tomography, diabetes, business.industry, lcsh:R, nutritional and metabolic diseases, Retinal, General Medicine, Diabetic retinopathy, medicine.disease, eye diseases, Ganglion, diabetic retinopathy, medicine.anatomical_structure, chemistry, microperimetry, 030221 ophthalmology & optometry, sense organs, medicine.symptom, OCTA, business, Microperimetry, 030217 neurology & neurosurgery
Abstract

The aim of this cross-sectional case-control study is to investigate the possible presence of vascular/neurodegenerative alterations in the retina of type 1 diabetes mellitus (T1DM) patients without diabetic retinopathy (DR). Thirty-four eyes of 34 consecutive T1DM without DR (mean age 21 &plusmn, 2 years) were included. Another cohort of 27 eyes (27 healthy control subjects matched with age and sex) was also recruited. All patients underwent multimodal imaging evaluation using structural optical coherence tomography (OCT), OCT-angiography (OCT-A), dynamic vessel analyzer (DVA) and microperimetry. No significant differences were disclosed comparing diabetics and controls for visual acuity, central macular thickness, and subfoveal choroidal thickness. On retinal nerve fiber layer and ganglion cell complex thickness, no significant differences were disclosed comparing each 3-mm-diameter macular and peripapillary subfield between two groups. Using OCT-A, deep capillary plexus perfusion density (PD) of diabetics was significantly lower compared to control group, whereas PD of other retinal/choriocapillaris plexuses and foveal avascular zone area did not show any significant difference. Using DVA, diabetic eyes revealed a significantly decreased vessel response to flicker light in comparison to controls. No differences were disclosed using microperimetry analysis. Taken together, these results suggest that vascular alterations could be the first detectable retinal change in the development of DR.

Published
2019
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45. Predictors of serious adverse events and non-response in cirrhotic patients with primary biliary cholangitis treated with obeticholic acid.

Author

De Vincentis A, D'Amato D, Cristoferi L, Gerussi A, Malinverno F, Lleo A, Colapietro F, Marra F, Galli A, Fiorini C, Coco B, Brunetto M, Niro GA, Cotugno R, Saitta C, Cozzolongo R, Losito F, Giannini EG, Labanca S, Marzioni M, Marconi G, Morgando A, Pellicano R, Vanni E, Cazzagon N, Floreani A, Chessa L, Morelli O, Muratori L, Pellicelli A, Pompili M, Ponziani F, Tortora A, Rosina F, Russello M, Cannavò M, Simone L, Storato S, Viganò M, Abenavoli L, D'Antò M, De Gasperi E, Distefano M, Scifo G, Zolfino T, Calvaruso V, Cuccorese G, Palitti VP, Sacco R, Bertino G, Frazzetto E, Alvaro D, Mulinacci G, Palermo A, Scaravaglio M, Terracciani F, Galati G, Ronca V, Zuin M, Claar E, Izzi A, Picardi A, Invernizzi P, Vespasiani-Gentilucci U, and Carbone M

Subjects
Albumins therapeutic use, Ascites drug therapy, Ascites etiology, Bilirubin, Chenodeoxycholic Acid analogs & derivatives, Humans, Liver Cirrhosis complications, Liver Cirrhosis drug therapy, Male, Liver Cirrhosis, Biliary complications, Liver Cirrhosis, Biliary drug therapy
Abstract

Background & Aims: Obeticholic acid (OCA) has recently been restricted in patients with primary biliary cholangitis (PBC) with "advanced cirrhosis" because of its narrow therapeutic index. We aimed to better define the predicting factors of hepatic serious adverse events (SAEs) and non-response in cirrhotic patients undergoing OCA therapy., Methods: Safety and efficacy of treatment were evaluated in a cohort of consecutive PBC cirrhotic patients started with OCA. OCA response was evaluated according to the Poise criteria. Risk factors for hepatic SAEs and non-response were reported as risk ratios (RR) with 95% confidence intervals (CIs)., Results: One hundred PBC cirrhotics were included, 97 Child-Pugh class A and 3 class B. Thirty-one had oesophageal varices and 5 had a history of ascites. Thirty-three per cent and 32% of patients achieved a biochemical response at 6 and 12 months respectively. Male sex (adjusted-RR 1.75, 95%CI 1.42-2.12), INR (1.37, 1.00-1.87), Child-Pugh score (1.79, 1.28-2.50), MELD (1.17, 1.04-1.30) and bilirubin (1.83, 1.11-3.01) were independently associated with non-response to OCA. Twenty-two patients discontinued OCA within 12 months: 10 for pruritus, 9 for hepatic SAEs (5 for jaundice and/or ascitic decompensation; 4 for upper digestive bleeding). INR (adjusted-RR 1.91, 95%CI 1.10-3.36), lower albumin levels (0.18, 0.06-0.51), Child-Pugh score (2.43, 1.50-4.04), history of ascites (3.5, 1.85-6.5) and bilirubin (1.30, 1.05-1.56), were associated with hepatic SAEs. A total bilirubin≥1.4 mg/dl at baseline was the most accurate biochemical predictor of hepatic SAEs under OCA., Conclusions: An accurate baseline assessment is crucial to select cirrhotic patients who can benefit from OCA. Although OCA is effective in one third of cirrhotics, bilirubin level ≥1.4 mg/dl should discourage from its use., (© 2022 The Authors. Liver International published by John Wiley & Sons Ltd.)

Published
2022
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