93 results on '"Mulford, J"'
Search Results
2. Trial of Vancomycin and Cefazolin as Surgical Prophylaxis in Arthroplasty
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Peel, TN, Astbury, S, Cheng, AC, Paterson, DL, Buising, KL, Spelman, T, An, T-D, Adie, S, Boyce, G, McDougall, C, Molnar, R, Mulford, J, Rehfisch, P, Solomon, M, Crawford, R, Harris-Brown, T, Roney, J, Wisniewski, J, de Steiger, R, ASAP, TG, Peel, TN, Astbury, S, Cheng, AC, Paterson, DL, Buising, KL, Spelman, T, An, T-D, Adie, S, Boyce, G, McDougall, C, Molnar, R, Mulford, J, Rehfisch, P, Solomon, M, Crawford, R, Harris-Brown, T, Roney, J, Wisniewski, J, de Steiger, R, and ASAP, TG
- Abstract
BACKGROUND: The addition of vancomycin to beta-lactam prophylaxis in arthroplasty may reduce surgical-site infections; however, the efficacy and safety are unclear. METHODS: In this multicenter, double-blind, superiority, placebo-controlled trial, we randomly assigned adult patients without known methicillin-resistant Staphylococcus aureus (MRSA) colonization who were undergoing arthroplasty to receive 1.5 g of vancomycin or normal saline placebo, in addition to cefazolin prophylaxis. The primary outcome was surgical-site infection within 90 days after surgery. RESULTS: A total of 4239 patients underwent randomization. Among 4113 patients in the modified intention-to-treat population (2233 undergoing knee arthroplasty, 1850 undergoing hip arthroplasty, and 30 undergoing shoulder arthroplasty), surgical-site infections occurred in 91 of 2044 patients (4.5%) in the vancomycin group and in 72 of 2069 patients (3.5%) in the placebo group (relative risk, 1.28; 95% confidence interval [CI], 0.94 to 1.73; P = 0.11). Among patients undergoing knee arthroplasty, surgical-site infections occurred in 63 of 1109 patients (5.7%) in the vancomyin group and in 42 of 1124 patients (3.7%) in the placebo group (relative risk, 1.52; 95% CI, 1.04 to 2.23). Among patients undergoing hip arthroplasty, surgical-site infections occurred in 28 of 920 patients (3.0%) in the vancomyin group and in 29 of 930 patients (3.1%) in the placebo group (relative risk, 0.98; 95% CI, 0.59 to 1.63). Adverse events occurred in 35 of 2010 patients (1.7%) in the vancomycin group and in 35 of 2030 patients (1.7%) in the placebo group, including hypersensitivity reactions in 24 of 2010 patients (1.2%) and 11 of 2030 patients (0.5%), respectively (relative risk, 2.20; 95% CI, 1.08 to 4.49), and acute kidney injury in 42 of 2010 patients (2.1%) and 74 of 2030 patients (3.6%), respectively (relative risk, 0.57; 95% CI, 0.39 to 0.83). CONCLUSIONS: The addition of vancomycin to cefazolin prophylaxis was not superi
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- 2023
3. Integrating a request for assistance model within the East Lothian MSK physiotherapy service
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Mulford, J., primary, Maxwell, A., additional, and Dickson, L., additional
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- 2022
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4. Challenges in recruiting clients for exercise and behaviour change interventions while waiting for joint replacement surgery
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Cheney, M, Bird, Marie-Louise, O'Brien, Jane, Brickwood, K-J, Mulford, J, Hamilton, K, Fell, James, Wu, S, Williams, Andrew, Cheney, M, Bird, Marie-Louise, O'Brien, Jane, Brickwood, K-J, Mulford, J, Hamilton, K, Fell, James, Wu, S, and Williams, Andrew
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Introduction and Aims: Patients awaiting hip or knee joint arthroplasty, often wait for 12 months or more and during this time have low levels of physical activity. Evidence suggests individualised exercise prescription before surgery can be highly beneficial for reducing the development of co-morbidities, however there are challenges in facilitating participation in exercise for these individuals. Method: A randomised control trial examining benefits of exercise and behaviour change for patients awaiting hip and knee arthroplasty. As study recruitment rates were lower than expected, those who declined to participate were invited to provide reasons for their decision. An analysis of these reasons has been conducted. Results: 485 patients were approached to participate in the study, of these 62 (13%) agreed and 423 declined (87%). Of the 423 patients who declined, 355 were asked their reason for not enrolling. Reasons for not participating fitted into 2 major themes; 36% (n=128) identified difficulties travelling to the location as a reason for declining and 15% (n= 53) didn’t want to participate in exercise. The remaining patients; 19% (n=67) provided a variety of reasons and 30% (n= 107) didn’t respond to repeated efforts to contact. Conclusion: Travel has been major factor affecting recruitment for the study examining exercise combined with behaviour change for people waiting for hip or knee arthroplasty. Potential participants were widely distributed across the state and the requirement to travel to only one location for the intervention negatively impacted recruitment. Investigations into alternative methods of delivery for future studies involving dispersed populations is therefore warranted.
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- 2021
5. A Combined Randomised and Observational Study of Surgery for Fractures in the distal Radius in the Elderly (CROSSFIRE): A statistical analyses plan
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Lawson, A, Naylor, J, Buchbinder, R, Ivers, R, Balogh, Z, Smith, P, Mittal, R, Xuan, W, Howard, K, Vafa, A, Yates, P, Rieger, B, Smith, G, Elkinson, I, Kim, W, Sungaran, J, Latendresse, K, Wong, J, Viswanathan, S, Landale, K, Drobetz, H, Tran, P, Page, R, Hau, R, Mulford, J, Incoll, I, Kale, M, Schick, B, Higgs, A, Oppy, A, Perriman, D, Harris, I, Lawson, A, Naylor, J, Buchbinder, R, Ivers, R, Balogh, Z, Smith, P, Mittal, R, Xuan, W, Howard, K, Vafa, A, Yates, P, Rieger, B, Smith, G, Elkinson, I, Kim, W, Sungaran, J, Latendresse, K, Wong, J, Viswanathan, S, Landale, K, Drobetz, H, Tran, P, Page, R, Hau, R, Mulford, J, Incoll, I, Kale, M, Schick, B, Higgs, A, Oppy, A, Perriman, D, and Harris, I
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Background: We are performing a combined randomised and observational study comparing internal fixation to non-surgical management for common wrist fractures in older patients. This paper describes the statistical analysis plan. Methods/design: A Combined Randomised and Observational Study of Surgery for Fractures In the distal Radius in the Elderly (CROSSFIRE) is a randomised controlled trial comparing two types of usual care for treating wrist fractures in older patients, surgical fixation using volar locking plates and non-surgical treatment using closed reduction and plaster immobilisation. The primary aim of this comparative-effectiveness study is to determine whether surgery is superior to non-surgical treatment with respect to patient-reported wrist function at 12 months post treatment. The secondary outcomes include radiographic outcomes, complication rates and patient-reported outcomes including quality of life, pain, treatment success and cosmesis. Primary analysis will use a two-sample t test and an intention-to-treat analysis using the randomised arm of the study. Statistical analyses will be two-tailed and significance will be determined by p < 0.05. Sensitivity analyses will be conducted to assess for differences in intention-to-treat, per-protocol and as-treated analyses. Sensitivity analyses will also be conducted to assess selection bias by evaluating differences in participants between the randomised and observational study arms, and for bias relating to any missing data. An economic analysis will be conducted separately if surgery is shown to provide superior outcomes to a level of clinical significance. Discussion: This statistical analysis plan describes the analysis of the CROSSFIRE study which aims to provide evidence to aid clinical decision-making in the treatment of distal radius fractures in older patients. Trial registration: CROSSFIRE was approved by The Hunter New England Human Research Ethics Committee (HNEHREC Reference No: 16/02/17/3
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- 2020
6. A prospective evaluation of trochleoplasty for the treatment of patellofemoral dislocation and instability
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Utting, M. R., Mulford, J. S., and Eldridge, J. D. J.
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- 2008
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7. EARLY RESULTS OF TROCHLEOPLASTY FOR PATIENTS WITH DYSPLASIA AND SYMPTOMATIC RECURRENT PATELLOFEMORAL INSTABILITY.
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Mulford, J S, Utting, M R, and Eldridge, J D J
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- 2008
8. A REVIEW OF REVISION PATELLOFEMORAL ARTHROPLASTY PATIENTS.
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Porteous, A J, Mulford, J S, Newman, J H, and Ackroyd, C E
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- 2008
9. Assessment and management of chronic patellofemoral instability
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Mulford, J. S., Wakeley, C. J., and Eldridge, J. D. J.
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- 2007
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10. Multicentre randomised double-blind placebo controlled trial of combination vancomycin and cefazolin surgical antibiotic prophylaxis: the Australian surgical antibiotic prophylaxis (ASAP) trial
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Peel, T, Astbury, S, Cheng, AC, Paterson, D, Buising, K, Spelman, T, An, T-D, de Steiger, RS, Choong, P, Cheng, A, Dowsey, M, Crawford, R, Clarke, P, Howden, B, Rehfisch, P, Molnar, R, Adie, S, Boyce, G, McDougall, C, Mulford, J, Solomon, M, Harris-Brown, T, Roney, J, Peleg, A, Wisniewski, J, Pereira, S, Badoordeen, Z, Peel, T, Astbury, S, Cheng, AC, Paterson, D, Buising, K, Spelman, T, An, T-D, de Steiger, RS, Choong, P, Cheng, A, Dowsey, M, Crawford, R, Clarke, P, Howden, B, Rehfisch, P, Molnar, R, Adie, S, Boyce, G, McDougall, C, Mulford, J, Solomon, M, Harris-Brown, T, Roney, J, Peleg, A, Wisniewski, J, Pereira, S, and Badoordeen, Z
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INTRODUCTION: Resistant Gram-positive organisms, such as methicillin-resistant staphylococci, account for a significant proportion of infections following joint replacement surgery. Current surgical antimicrobial prophylaxis guidelines recommend the use of first-generation or second-generation cephalosporin antibiotics, such as cefazolin. Cefazolin, however, does not prevent infections due to these resistant organisms; therefore, new prevention strategies need to be examined. One proposed strategy is to combine a glycopeptide antibiotic with cefazolin for prophylaxis. The clinical benefit and cost-effectiveness of this combination therapy compared with usual therapy, however, have not been established. METHODS AND ANALYSIS: This randomised, double-blind, parallel, superiority, placebo-controlled, phase 4 trial will compare the incidence of all surgical site infections (SSIs) including superficial, deep and organ/space (prosthetic joint) infections, safety and cost-effectiveness of surgical prophylaxis with cefazolin plus vancomycin to that with cefazolin plus placebo. The study will be performed in patients undergoing joint replacement surgery. In the microbiological sub-studies, we will examine the incidence of SSIs in participants with preoperative staphylococci colonisation (Sub-Study 1) and incidence of VRE acquisition (Sub-Study 2). The trial will recruit 4450 participants over a 4-year period across 13 orthopaedic centres in Australia. The primary outcome is the incidence of SSI at 90 days post index surgery. Secondary outcomes include the incidence of SSI according to joint and microorganism and other healthcare associated infections. Safety endpoints include the incidence of acute kidney injury, hypersensitivity reactions and all-cause mortality. The primary and secondary analysis will be a modified intention-to-treat analysis consisting of all randomised participants who undergo eligible surgery. We will also perform a per-protocol analysis. ETHICS AND DISS
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- 2019
11. Coconut palm-related injuries in the pacific islands
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Mulford, J. S., Oberli, H., and Tovosia, S.
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- 2001
12. OSTEOMYELITIS CAUSED BY LEUCONOSTOC SPECIES
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Mulford, J. S. and Mills, J.
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- 1999
13. A combined randomised and observational study of surgery for fractures in the distal radius in the elderly (CROSSFIRE) - A study protocol
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Harris, IA, Naylor, JM, Lawson, A, Buchbinder, R, Ivers, R, Balogh, Z, Smith, P, Mittal, R, Xuan, W, Howard, K, Vafa, A, Yates, P, Rieger, B, Smith, G, Elkinson, I, Kim, W, Chehade, M, Sungaran, J, Latendresse, K, Wong, J, Viswanathan, S, Richardson, M, Shrestha, K, Drobetz, H, Tran, P, Loveridge, J, Page, R, Hau, R, Bingham, R, Mulford, J, Incoll, I, Harris, IA, Naylor, JM, Lawson, A, Buchbinder, R, Ivers, R, Balogh, Z, Smith, P, Mittal, R, Xuan, W, Howard, K, Vafa, A, Yates, P, Rieger, B, Smith, G, Elkinson, I, Kim, W, Chehade, M, Sungaran, J, Latendresse, K, Wong, J, Viswanathan, S, Richardson, M, Shrestha, K, Drobetz, H, Tran, P, Loveridge, J, Page, R, Hau, R, Bingham, R, Mulford, J, and Incoll, I
- Abstract
Fractures of the distal radius are common and occur in all age groups. The incidence is high in older populations due to osteoporosis and increased falls risk. Considerable practice variation exists in the management of distal radius fractures in older patients ranging from closed reduction with cast immobilisation to open reduction with plate fixation. Plating is currently the most common surgical treatment. While there is evidence showing no significant advantage for some forms of surgical fixation over conservative treatment, and no difference between different surgical techniques, there is a lack of evidence comparing two of the most common treatments used: closed reduction and casting versus plating. Surgical management involves significant costs and risks compared with conservative management. High-level evidence is required to address practice variation, justify costs and to provide the best clinical outcomes for patients. Methods and analysis This pragmatic, multicentre randomised comparative effectiveness trial aims to determine whether plating leads to better pain and function and is more cost-effective than closed reduction and casting of displaced distal radius fractures in adults aged 60 years and older. The trial will compare the two techniques but will also follow consenting patients who are unwilling to be randomised in a separate, observational cohort. Inclusion of non-randomised patients addresses selection bias, provides practice and outcome insights about standard care, and improves the generalisability of the results from the randomised trial. Ethics and dissemination CROSSFIRE(Combined Randomised and Observational Study of Surgery for Fractures In the distal Radius in the Elderly) was reviewed and approved by The Hunter New England HREC (HNEHREC Reference No: 16/02/17/3.04). The results of the trial will be published in a peer-reviewed journal and will be disseminated via various forms of media. Results will be incorporated in clinical recommen
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- 2017
14. Proximal Row Carpectomy vs Four Corner Fusion for Scapholunate (Slac) or Scaphoid Nonunion Advanced Collapse (Snac) Wrists: A Systematic Review of Outcomes
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MULFORD, J. S., primary, CEULEMANS, L. J., additional, NAM, D., additional, and AXELROD, T. S., additional
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- 2009
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15. Fractured neck of femur and vitamin D levels in southern Tasmania
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Inderjeeth, CA, primary, Al-Lahham, Y, additional, Barrett, T, additional, Mulford, J, additional, and Nicklason, F, additional
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- 2000
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16. OSTEOMYELITIS CAUSED BYLEUCONOSTOCSPECIES
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Mulford, J. S., primary and Mills, J., additional
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- 1999
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17. Therapeutic interventions related to outcome in psychodynamic psychotherapy for anxiety disorder patients.
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Slavin-Mulford J, Hilsenroth M, Weinberger J, and Gold J
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This is the first study with acceptable inter-rater reliability to examine specific therapeutic techniques related to change in anxiety disorder patients during short-term psychodynamic psychotherapy. The study first examined the effectiveness of short-term psychodynamic psychotherapy and results showed significant and positive pre-/post-treatment changes on both patient and independent clinical ratings for anxiety, global symptomatology, relational, social, and occupational functioning. Likewise, the majority of patients (76%) reported anxiety symptoms within a normal distribution at termination. Importantly, psychodynamic interventions rated early in treatment (third/fourth session) were positively related to changes in anxiety symptoms. Further, results showed that several individual psychodynamic techniques were meaningfully related to outcome including (1) focusing on wishes, fantasies, dreams, and early memories; (2) linking current feelings or perceptions to the past; (3) highlighting patients' typical relational patterns; and (4) helping patients to understand their experiences in new ways. Clinical applications are discussed. [ABSTRACT FROM AUTHOR]
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- 2011
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18. Technique of Trochleoplasty for the Treatment of Patella Instability.
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Mulford, J. S. and Eldridge, J. D. J.
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OPERATIVE surgery , *KNEE surgery , *PATELLA diseases , *JOINT hypermobility , *SURGICAL complications - Abstract
The article describes the investigative methods and surgical technique of trochleoplasty for the treatment of patella instability. Trochleoplasty is an option for patients with trochlear dysplasia who have failed appropriate nonoperative management or previous operative treatment. The article offers information on multiple imaging modalities used to investigate the patellofemoral joint, as well as the general complications associated with open knee surgery.
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- 2008
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19. Anecdotes of the Desert.
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MULFORD, J. H.
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- 1864
20. FONOTIPI FOR FORENERZ.
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Mulford, J. H.
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- 1858
21. UNTITLED.
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SANDERSON, H. and MULFORD, J. N.
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- 1859
22. Touring Map of the Custer Battlefield Hiway The Scenic Route to the West.
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Mulford, John C., National Highways Association, and Faunce, C.C.
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Automobile ,Roads - Abstract
Part of the "Good Roads Everywhere" series promoting "A Paved United States In Our Day."
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- 1925
23. Good Roads Everywhere. National Highways Map Of The State Of Pennsylvania Showing Three Thousand Miles Of National Highways.
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Mulford, John C. and National Highways Association
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Automobile ,Roads - Abstract
"Until the late 19th century, roads in the United States were almost universally recognized as a local or state responsibility. Privately owned railroads dominated much of the interstate commerce, and the idea of a federally funded network of roads didn’t gain much traction until the 1890s. Cyclists, oddly enough, were some of the most vocal proponents of early road funding legislature, and ultimately the ubiquity of the automobile (spearheaded by Henry Ford’s affordable 1907 Model-T) would compel Congress to pass a series of legislative measures approving federal funding for the construction of roads. These laws, starting with the Federal Road Aid Act of 1916, were encouraged by various interest groups, but few were as successful as the National Highways Association (NHA). The NHA was organized in 1911 to promote the development, funding, and construction of ‘Good Roads Everywhere.’ Highways would ultimately become just one component of this broader network of interconnected transportation routes, described in some detail at the bottom of this map showing the proposed system across Pennsylvania. Bright red lines connecting nearly every corner of the state are punctuated by dozens of towns served by each proposed highway route. Though the shaded topography gives some indication of the rugged terrain that would certainly complicate construction, text at the bottom of the sheet assuages possible concerns by highlighting the overwhelming proportion of Pennsylvanians who would have access to the new roads. This is the first edition of the map, designed by NHA Chief Cartographer John C. Mulford and published in September, 1915 by the National Highways Association in Washington, D.C. Printing and lithography were performed by the M.B. Brown Printing and Binding Company of New York. Similar maps showing proposed networks across other states, and the entire United States, would continue to be produced by the NHA until the mid-1920s. All examples are scarce on the market, though the individual state sheets are less common. WorldCat identifies five examples – the Wisconsin Historical Society, University of Illinois, New York State Library, Yale, and Harvard." (Curtis Wright, 2022)
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- 1915
24. United States Touring Map Showing 250,000 Miles of Principal Traveled Highways including National Park-to-Park Highway ... Issued by Keystone Automobile Club, The Automobile Club of America, National Highways Association.
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Mulford, John C. and A. Hoen & Co.
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Transportation ,Roads - Abstract
4th edition. Full color. A promotional piece encouraging the improvement of roadways nationwide using the phrase, "Good Roads Everywhere." It also promotes the Oregon Trail, compares the development of the Panama Canal with the road system, and provides many interesting facts and perspectives pertaining to roads.
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- 1929
25. National highways : 50,000 miles industrial and military : four way motor-ways build and forever maintained by the United States Government : capital to capital. Issued by the National Highways Association, the Automobile Club of America, the Society of American Military Engineers. Made by Map shop of the N.H.A. Washington, D.C. U. S. John C. Mulford, chief cartographer ; C.C. Faunce, cartographer. Lithographed and printed by A. Hoen & Co., Baltimore, Md.
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Mulford, John C., Faunce, C. C., Society of American Military Engineers, National Highways Association, The Automobile Club of America., and A. Hoen & Co.
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Roads ,Pictorial map - Abstract
Color pictorial map of the proposed United States highway system, depicts a nation wide highway system linking all regions of the country. The chart below map shows a progressive expansion of the highway network to be built as traffic and military needs of the nation require from one-way to two-ways to three and four ways. Includes state boundaries, major cities and notes.
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- 1928
26. Good roads everywhere : Four fold system of highways-national highways-state highways-county roads-township or town roads ... (Cover title) United States touring map : showing 150,000 miles of principal traveled highways, including Associated Tours of the Automobile Club of America ... National park--to--park highway. Issued by the Automobile Club of America and National Highways Association ; John C. Mulford, chief cartographer, C.C. Faunce, cartographer ; lithographed by A. Hoen & Co. 19th edition copyright 1926 by National Highways Association.
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Automobile Club of America, National Highways Association, Mulford, John C., Faunce, C.C., and hoen & Co.
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Roads - Abstract
Color folded map of the United States highways, 86x126. Depicting the coast to coast highway network. The map was issued jointly by the National Highways Association and the Automobile Club of America with the object of promoting national highway systems. Cartography by John C. Mulford and C.C. Faunce. lithographed and printed by A. Hoen & Company, Baltimore. Includes numerous text block to the extensive information in the history of road building, information on the four fold system of highways, and organizational information on the National Highways Association including members of various councils. Shows state boundaries, cities, towns and many Indian Reservations in the United States in yellow., See notefield above.
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- 1926
27. Noisy Robots? Comparison of Occupational Noise Levels Between Robotic-Assisted and Conventional Total Knee Arthroplasty.
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Willemot L, Gilmour A, Mulford J, and Penn D
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Background: Noise exposure during surgery is a known occupational hazard, impacting staff hearing and surgical outcomes. Despite guidelines such as the Australian Work Health and Safety Act, noise safety remains largely neglected in orthopaedic surgery. Anecdotally, the introduction of robotic-assisted arthroplasty has contributed to increased noise production. This research article aims to investigate the role of robots in noise levels during arthroplasty., Methods: In this prospective observational study, we collected noise exposure data during total knee arthroplasty with and without robotic assistance. Noise levels were measured using a smartphone placed in the surgeon's breast pocket. Patient demographics and surgical details were collected for subgroup analysis. Mean (LAeq), time-weighted average, and peak noise levels, as well as dose equivalent were calculated to quantify the exposure., Results: A total of 65 knee arthroplasty sound recordings were included with a mean noise level of 82.0 dB (standard deviation [SD]: 3.9). Robotic-assisted surgeries exhibited significantly higher levels than using the conventional technique: 82.4 (SD: 3.2) vs 78.4 dB (SD: 3.8) (<0.0001). These values exceed some of the recommended guidelines. Peak exposure levels were similar in both categories at 109.6 (SD: 2.7) and 110.7 dB (SD: 4.3), remaining below the safety threshold., Conclusions: This study highlights the potential for harmful noise exposure in orthopaedic surgery, emphasizing the contribution of robotic-assisted procedures. Our findings indicate noise levels approximate or exceed international safety guidelines. The results support the wearing of personal protective hearing equipment, and other preventative strategies. Our study provides insights into an underappreciated aspect of orthopaedic surgery., (© 2024 The Authors.)
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- 2024
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28. Adding Behaviour-Change Counselling to an Exercise Program for Adults Preparing for Hip and Knee Arthroplasty Improves Psychological and Physical Wellness: Focus Group Reflections.
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Bird ML, Mulford J, Williams AD, Cheney M, and O'Brien J
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- Humans, Adult, Focus Groups, Exercise Therapy, Counseling, Arthroplasty, Replacement, Knee, Osteoarthritis, Knee psychology
- Abstract
Purpose: To explore participant experiences for people on an arthroplasty waitlist, randomised to an exercise and behaviour-change counselling program (ENHANCE). The ENHANCE program for arthroplasty patients was led by an accredited exercise physiologist who delivered an individually tailored and structured exercise program. Included in the exercise program were up to five in-person counselling sessions, based on the Health Action Process Approach (HAPA) applied specifically to people with osteoarthritis. Nine adults (mean 69.4 years) who were on the waiting list for a total hip or knee arthroplasty and who had completed a 12-week program (ENHANCE) as part of a randomised controlled trial were recruited for this study., Methods: Two focus groups were conducted to explore participant experiences of ENHANCE. Data were analysed using inductive thematic analysis with constructs of the HAPA (motivational and volitional factors) as a framework., Results: We identified three themes (1) 'The structured program addressed inactivity and improved feelings of wellness and preparation for the operation'. The benefits were not only physical, but psychological and were contextualised in terms of preparation for the upcoming surgery. (2) 'People as enablers of participation': Participants identified that the attitude, and skill of the experienced instructor were supportive and motivating, especially in tailoring the intervention. Within the program, the support of the group was considered a positive attribute (3) 'Improved awareness changed attitudes to self-efficacy and perceived self-control'. Participants described an increased awareness of their condition and a better understanding of health expectations. They felt more control and ownership over their health journey., Conclusion: Goal setting and social support were identified factors in a behaviour-change counselling program, delivered in conjunction with structured exercise that led to a positive experience. Improved psychological and physical health were described. Participants were better prepared for their upcoming surgery, with increased self efficacy and mastery to support long-term physical-activity engagement.
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- 2023
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29. Trial of Vancomycin and Cefazolin as Surgical Prophylaxis in Arthroplasty.
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Peel TN, Astbury S, Cheng AC, Paterson DL, Buising KL, Spelman T, Tran-Duy A, Adie S, Boyce G, McDougall C, Molnar R, Mulford J, Rehfisch P, Solomon M, Crawford R, Harris-Brown T, Roney J, Wisniewski J, and de Steiger R
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- Adult, Humans, Arthroplasty, Replacement, Knee adverse effects, Arthroplasty, Replacement, Knee methods, Australia, Methicillin-Resistant Staphylococcus aureus, Staphylococcal Infections epidemiology, Staphylococcal Infections prevention & control, Staphylococcal Infections drug therapy, Double-Blind Method, Anti-Bacterial Agents adverse effects, Anti-Bacterial Agents therapeutic use, Antibiotic Prophylaxis adverse effects, Antibiotic Prophylaxis methods, Cefazolin adverse effects, Cefazolin therapeutic use, Surgical Wound Infection epidemiology, Surgical Wound Infection prevention & control, Surgical Wound Infection etiology, Vancomycin adverse effects, Vancomycin therapeutic use, Arthroplasty, Replacement adverse effects, Arthroplasty, Replacement methods, Arthroplasty, Replacement statistics & numerical data
- Abstract
Background: The addition of vancomycin to beta-lactam prophylaxis in arthroplasty may reduce surgical-site infections; however, the efficacy and safety are unclear., Methods: In this multicenter, double-blind, superiority, placebo-controlled trial, we randomly assigned adult patients without known methicillin-resistant Staphylococcus aureus (MRSA) colonization who were undergoing arthroplasty to receive 1.5 g of vancomycin or normal saline placebo, in addition to cefazolin prophylaxis. The primary outcome was surgical-site infection within 90 days after surgery., Results: A total of 4239 patients underwent randomization. Among 4113 patients in the modified intention-to-treat population (2233 undergoing knee arthroplasty, 1850 undergoing hip arthroplasty, and 30 undergoing shoulder arthroplasty), surgical-site infections occurred in 91 of 2044 patients (4.5%) in the vancomycin group and in 72 of 2069 patients (3.5%) in the placebo group (relative risk, 1.28; 95% confidence interval [CI], 0.94 to 1.73; P = 0.11). Among patients undergoing knee arthroplasty, surgical-site infections occurred in 63 of 1109 patients (5.7%) in the vancomyin group and in 42 of 1124 patients (3.7%) in the placebo group (relative risk, 1.52; 95% CI, 1.04 to 2.23). Among patients undergoing hip arthroplasty, surgical-site infections occurred in 28 of 920 patients (3.0%) in the vancomyin group and in 29 of 930 patients (3.1%) in the placebo group (relative risk, 0.98; 95% CI, 0.59 to 1.63). Adverse events occurred in 35 of 2010 patients (1.7%) in the vancomycin group and in 35 of 2030 patients (1.7%) in the placebo group, including hypersensitivity reactions in 24 of 2010 patients (1.2%) and 11 of 2030 patients (0.5%), respectively (relative risk, 2.20; 95% CI, 1.08 to 4.49), and acute kidney injury in 42 of 2010 patients (2.1%) and 74 of 2030 patients (3.6%), respectively (relative risk, 0.57; 95% CI, 0.39 to 0.83)., Conclusions: The addition of vancomycin to cefazolin prophylaxis was not superior to placebo for the prevention of surgical-site infections in arthroplasty among patients without known MRSA colonization. (Funded by the Australian National Health and Medical Research Council; Australian New Zealand Clinical Trials Registry number, ACTRN12618000642280.)., (Copyright © 2023 Massachusetts Medical Society.)
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- 2023
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30. Effect of Aspirin vs Enoxaparin on 90-Day Mortality in Patients Undergoing Hip or Knee Arthroplasty: A Secondary Analysis of the CRISTAL Cluster Randomized Trial.
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Sidhu VS, Kelly TL, Pratt N, Graves SE, Buchbinder R, Adie S, Cashman K, Ackerman IN, Bastiras D, Brighton R, Burns AWR, Chong BH, Clavisi O, Cripps M, Dekkers M, de Steiger R, Dixon M, Ellis A, Griffith EC, Hale D, Hansen A, Harris A, Hau R, Horsley M, James D, Khorshid O, Kuo L, Lewis PL, Lieu D, Lorimer M, MacDessi SJ, McCombe P, McDougall C, Mulford J, Naylor JM, Page RS, Radovanovic J, Solomon M, Sorial R, Summersell P, Tran P, Walter WL, Webb S, Wilson C, Wysocki D, and Harris IA
- Subjects
- Adult, Humans, Female, Adolescent, Aged, Male, Enoxaparin therapeutic use, Enoxaparin adverse effects, Aspirin therapeutic use, Venous Thromboembolism drug therapy, Arthroplasty, Replacement, Knee adverse effects, Arthroplasty, Replacement, Hip adverse effects
- Abstract
Importance: Ischemic heart disease remains the leading cause of mortality following hip and knee arthroplasty. Due to its antiplatelet and cardioprotective properties, aspirin has been proposed as an agent that could reduce mortality when used as venous thromboembolism (VTE) prophylaxis following these procedures., Objective: To compare aspirin with enoxaparin in reducing 90-day mortality for patients undergoing hip or knee arthroplasty procedures., Design, Setting, and Participants: This study was a planned secondary analysis of the CRISTAL cluster randomized, crossover, registry-nested trial performed across 31 participating hospitals in Australia between April 20, 2019, and December 18, 2020. The aim of the CRISTAL trial was to determine whether aspirin was noninferior to enoxaparin in preventing symptomatic VTE following hip or knee arthroplasty. The primary study restricted the analysis to patients undergoing total hip or knee arthroplasty for a diagnosis of osteoarthritis only. This study includes all adult patients (aged ≥18 years) undergoing any hip or knee arthroplasty procedure at participating sites during the course of the trial. Data were analyzed from June 1 to September 6, 2021., Interventions: Hospitals were randomized to administer all patients oral aspirin (100 mg daily) or subcutaneous enoxaparin (40 mg daily) for 35 days after hip arthroplasty and 14 days after knee arthroplasty procedures., Main Outcomes and Measures: The primary outcome was mortality within 90 days. The between-group difference in mortality was estimated using cluster summary methods., Results: A total of 23 458 patients from 31 hospitals were included, with 14 156 patients allocated to aspirin (median [IQR] age, 69 [62-77] years; 7984 [56.4%] female) and 9302 patients allocated to enoxaparin (median [IQR] age, 70 [62-77] years; 5277 [56.7%] female). The mortality rate within 90 days of surgery was 1.67% in the aspirin group and 1.53% in the enoxaparin group (estimated difference, 0.04%; 95% CI, -0.05%-0.42%). For the subgroup of 21 148 patients with a nonfracture diagnosis, the mortality rate was 0.49% in the aspirin group and 0.41% in the enoxaparin group (estimated difference, 0.05%; 95% CI, -0.67% to 0.76%)., Conclusions and Relevance: In this secondary analysis of a cluster randomized trial comparing aspirin with enoxaparin following hip or knee arthroplasty, there was no significant between-group difference in mortality within 90 days when either drug was used for VTE prophylaxis., Trial Registration: http://anzctr.org.au Identifier: ACTRN12618001879257.
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- 2023
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31. Introduction to surgical coaching.
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Willemot L, Lee MJ, and Mulford J
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- Humans, Clinical Competence, Mentoring methods, Surgeons, Burnout, Professional prevention & control
- Abstract
Surgical coaching is a new approach to continuous professional development (CPD). Advocates claim that coaching improves surgical and non-technical skills, leading to enhanced performance and reduced stress and burnout. Widespread acceptance of coaching in the surgical community is limited due to a paucity of evidence, surgery-specific obstacles and lack of resources. This narrative review introduces what 'surgical coaching' is and describes its origins. Coaching techniques are based on live or video observation of procedures, followed by collaborative analysis, reflection and goal planning in a non-competitive setting aided by an expert, peer or lay coach. Technical skills improvements have been reported using coaching techniques, yet long-term influence on non-technical competencies, overall performance and surgeon wellbeing are largely hypothetical. There are clear potential benefits in the application of surgical coaching to daily surgical practice. However, significant knowledge gaps remain. Dedicated research into the short-term applicability and the long-term effects of surgical coaching are required., (© 2023 Royal Australasian College of Surgeons.)
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- 2023
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32. A desirability of outcome ranking (DOOR) for periprosthetic joint infection - a Delphi analysis.
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Johns BP, Dewar DC, Loewenthal MR, Manning LA, Atrey A, Atri N, Campbell DG, Dunbar M, Kandel C, Khoshbin A, Jones CW, Lora-Tamayo J, McDougall C, Moojen DJF, Mulford J, Paterson DL, Peel T, Solomon M, Young SW, and Davis JS
- Abstract
Background : Treatment outcomes in studies on prosthetic joint infection are generally assessed using a dichotomous outcome relating to treatment success or failure. These outcome measures neither include patient-centred outcome measures including joint function and quality of life, nor do they account for adverse effects of treatment. A desirability of outcome ranking (DOOR) measure can include these factors and has previously been proposed and validated for other serious infections. We aimed to develop a novel DOOR for prosthetic joint infections (PJIs). Methods : The Delphi method was used to develop a DOOR for PJI research. An international working group of 18 clinicians (orthopaedic surgeons and infectious disease specialists) completed the Delphi process. The final DOOR comprised the dimensions established to be most important by consensus with > 75 % of participant agreement. Results : The consensus DOOR comprised four main dimensions. The primary dimension was patient-reported joint function. The secondary dimensions were infection cure and mortality. The final dimension of quality of life was selected as a tie-breaker. Discussion : A desirability of outcome ranking for periprosthetic joint infection has been proposed. It focuses on patient-centric outcome measures of joint function, cure and quality of life. This DOOR provides a multidimensional assessment to comprehensively rank outcomes when comparing treatments for prosthetic joint infection., Competing Interests: The contact author has declared that none of the authors has any competing interests., (Copyright: © 2022 Brenton P. Johns et al.)
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- 2022
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33. Effect of combined exercise training and behaviour change counselling versus usual care on physical activity in patients awaiting hip and knee arthroplasty: A randomised controlled trial.
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Williams AD, O'Brien J, Mulford J, Mathew R, Thapa DK, Hamilton K, Cheney M, Schmidt M, Wu S, and Bird ML
- Abstract
Objective: This study aimed to determine if a novel intervention that combined individualised exercise training with behaviour change counselling based on Health Action Process Approach (HAPA) constructs could elicit long-term increase in physical activity (PA) and reduce comorbidity development among people requiring hip or knee arthroplasty., Method: A pre-registered two arm, parallel group, randomised controlled trial comparing the effect of a 12-week individualised exercise program combined with behavioural counselling delivered by accredited exercise physiologists, versus usual care to Osteoarthritis (OA) patients on public surgery waitlists. Participants were followed up at 6 months after baseline (pre-surgery) and again at 6 months post-surgery. Within and between group differences in post-surgery PA (as measured by ActivPal accelerometer), pain, function, quality of life, HAPA-based behavioural and psychological constructs, and health risk factors were analysed., Results: 63 participants (34 Female; Mean age = 66.4 ± 7.2 yrs) consented to participate in this study. At 6 months post baseline and 6 months post-surgery there were significant improvements in PA, pain, function, and quality of life, however there were no significant differences in the between group responses. Significant between group changes were observed in several psychological constructs related to volition at 6 months post baseline; however, these had disappeared by 6 months post-surgery., Conclusions: An exercise program and HAPA guided counselling intervention can improve psychological constructs related to exercise behaviour; however, these did not result in significant between group changes in PA at the timepoints measured. Further research with larger sample size is required. Trial Registration: Australian New Zealand Clinical Trials Registry (ACTRN 12617000357358) Date of registration: 08/03/2017., Competing Interests: The authors declare they have no competing interests., (© 2022 The Authors.)
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- 2022
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34. Effect of Aspirin vs Enoxaparin on Symptomatic Venous Thromboembolism in Patients Undergoing Hip or Knee Arthroplasty: The CRISTAL Randomized Trial.
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Sidhu VS, Kelly TL, Pratt N, Graves SE, Buchbinder R, Adie S, Cashman K, Ackerman I, Bastiras D, Brighton R, Burns AWR, Chong BH, Clavisi O, Cripps M, Dekkers M, de Steiger R, Dixon M, Ellis A, Griffith EC, Hale D, Hansen A, Harris A, Hau R, Horsley M, James D, Khorshid O, Kuo L, Lewis P, Lieu D, Lorimer M, MacDessi S, McCombe P, McDougall C, Mulford J, Naylor JM, Page RS, Radovanovic J, Solomon M, Sorial R, Summersell P, Tran P, Walter WL, Webb S, Wilson C, Wysocki D, and Harris IA
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- Aged, Australia, Chemoprevention, Female, Humans, Male, Osteoarthritis surgery, Postoperative Complications prevention & control, Pulmonary Embolism etiology, Pulmonary Embolism prevention & control, Anticoagulants adverse effects, Anticoagulants therapeutic use, Arthroplasty, Replacement, Hip adverse effects, Arthroplasty, Replacement, Knee adverse effects, Aspirin adverse effects, Aspirin therapeutic use, Enoxaparin adverse effects, Enoxaparin therapeutic use, Venous Thromboembolism etiology, Venous Thromboembolism prevention & control
- Abstract
Importance: There remains a lack of randomized trials investigating aspirin monotherapy for symptomatic venous thromboembolism (VTE) prophylaxis following total hip arthroplasty (THA) or total knee arthroplasty (TKA)., Objective: To determine whether aspirin was noninferior to enoxaparin in preventing symptomatic VTE after THA or TKA., Design, Setting, and Participants: Cluster-randomized, crossover, registry-nested trial across 31 hospitals in Australia. Clusters were hospitals performing greater than 250 THA or TKA procedures annually. Patients (aged ≥18 years) undergoing hip or knee arthroplasty procedures were enrolled at each hospital. Patients receiving preoperative anticoagulation or who had a medical contraindication to either study drug were excluded. A total of 9711 eligible patients were enrolled (5675 in the aspirin group and 4036 in the enoxaparin group) between April 20, 2019, and December 18, 2020. Final follow-up occurred on August 14, 2021., Interventions: Hospitals were randomized to administer aspirin (100 mg/d) or enoxaparin (40 mg/d) for 35 days after THA and for 14 days after TKA. Crossover occurred after the patient enrollment target had been met for the first group. All 31 hospitals were initially randomized and 16 crossed over prior to trial cessation., Main Outcomes and Measures: The primary outcome was symptomatic VTE within 90 days, including pulmonary embolism and deep venous thrombosis (DVT) (above or below the knee). The noninferiority margin was 1%. Six secondary outcomes are reported, including death and major bleeding within 90 days. Analyses were performed by randomization group., Results: Enrollment was stopped after an interim analysis determined the stopping rule was met, with 9711 patients (median age, 68 years; 56.8% female) of the prespecified 15 562 enrolled (62%). Of these, 9203 (95%) completed the trial. Within 90 days of surgery, symptomatic VTE occurred in 256 patients, including pulmonary embolism (79 cases), above-knee DVT (18 cases), and below-knee DVT (174 cases). The symptomatic VTE rate in the aspirin group was 3.45% and in the enoxaparin group was 1.82% (estimated difference, 1.97%; 95% CI, 0.54%-3.41%). This failed to meet the criterion for noninferiority for aspirin and was significantly superior for enoxaparin (P = .007). Of 6 secondary outcomes, none were significantly better in the enoxaparin group compared with the aspirin group., Conclusions and Relevance: Among patients undergoing hip or knee arthroplasty for osteoarthritis, aspirin compared with enoxaparin resulted in a significantly higher rate of symptomatic VTE within 90 days, defined as below- or above-knee DVT or pulmonary embolism. These findings may be informed by a cost-effectiveness analysis., Trial Registration: ANZCTR Identifier: ACTRN12618001879257.
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- 2022
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35. Plating vs Closed Reduction for Fractures in the Distal Radius in Older Patients: A Secondary Analysis of a Randomized Clinical Trial.
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Lawson A, Naylor J, Buchbinder R, Ivers R, Balogh ZJ, Smith P, Xuan W, Howard K, Vafa A, Perriman D, Mittal R, Yates P, Rieger B, Smith G, Adie S, Elkinson I, Kim W, Sungaran J, Latendresse K, Wong J, Viswanathan S, Landale K, Drobetz H, Tran P, Page R, Beattie S, Mulford J, Incoll I, Kale M, Schick B, Li T, Higgs A, Oppy A, and Harris IA
- Subjects
- Aged, Bone Plates, Female, Fracture Fixation, Internal adverse effects, Humans, Pain etiology, Radius, Treatment Outcome, Radius Fractures complications, Radius Fractures surgery
- Abstract
Importance: Distal radius fractures are common and are managed with or without surgery. Current evidence indicates surgical treatment is not superior to nonsurgical treatment at 12 months., Objective: Does surgical treatment for displaced distal radius fractures in patients 60 years or older provide better patient-reported wrist pain and function outcomes than nonsurgical treatment at 24 months?, Design, Setting, and Participants: In this secondary analysis of a combined multicenter randomized clinical trial (RCT) and a parallel observational study, 300 patients were screened from 19 centers in Australia and New Zealand. Of these, 166 participants were randomized to surgical or nonsurgical treatment. Participants who declined randomization (n = 134) were included in the parallel observational group with the same treatment options and follow-up. Participants were followed up at 3, 12, and 24 months by a blinded assessor. The 24-month outcomes are reported herein. Data were collected from December 1, 2016, to December 31, 2020, and analyzed from February 4 to October 21, 2021., Interventions: Surgical treatment consisting of open reduction and internal fixation using a volar-locking plate (VLP group) and nonsurgical treatment consisting of closed reduction and cast immobilization (CR group)., Main Outcomes and Measures: The primary outcome was patient-reported function using the Patient-Rated Wrist Evaluation (PRWE) questionnaire. Secondary outcomes included health-related quality of life, wrist pain, patient-reported treatment success, patient-rated bother with appearance, and posttreatment complications., Results: Among the 166 randomized and 134 observational participants (300 participants; mean [SD] age, 71.2 [7.5] years; 269 women [89.7%]), 151 (91.0%) randomized and 118 (88.1%) observational participants were followed up at 24 months. In the RCT, no clinically important difference occurred in mean PRWE scores at 24 months (13.6 [95% CI, 9.1-18.1] points for VLP fixation vs 15.8 [95% CI, 11.3-20.2] points for CR; mean difference, 2.1 [95% CI, -4.2 to 8.5]; P = .50). There were no between-group differences in all other outcomes except for patient-reported treatment success, which favored VLP fixation (33 of 74 [44.6%] in the CR group vs 54 of 72 [75.0%] in the VLP fixation group reported very successful treatment; P = .002). Rates of posttreatment complications were generally low and similar between treatment groups, including deep infection (1 of 76 [1.3%] in the CR group vs 0 of 75 in the VLP fixation group) and complex regional pain syndrome (2 of 76 [2.6%] in the CR group vs 1 of 75 [1.3%] in the VLP fixation group). The 24-month trial outcomes were consistent with 12-month outcomes and with outcomes from the observational group., Conclusions and Relevance: Consistent with previous reports, these findings suggest that VLP fixation may not be superior to CR for displaced distal radius fractures for patient-rated wrist function in persons 60 years or older during a 2-year period. Significantly higher patient-reported treatment success at 2 years in the VLP group may be attributable to other treatment outcomes not captured in this study., Trial Registration: ANZCTR.org Identifier: ACTRN12616000969460.
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- 2022
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36. The effectiveness of leucocyte-poor platelet-rich plasma injections on symptomatic early osteoarthritis of the knee: the PEAK randomized controlled trial.
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Lewis E, Merghani K, Robertson I, Mulford J, Prentice B, Mathew R, Van Winden P, and Ogden K
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- Humans, Injections, Intra-Articular, Knee Joint, Saline Solution, Treatment Outcome, Osteoarthritis, Knee therapy, Platelet-Rich Plasma
- Abstract
Aims: Platelet-rich plasma (PRP) intra-articular injections may provide a simple and minimally invasive treatment for early-stage knee osteoarthritis (OA). This has led to an increase in its adoption as a treatment for knee OA, although there is uncertainty about its efficacy and benefit. We hypothesized that patients with early-stage symptomatic knee OA who receive multiple PRP injections will have better clinical outcomes than those receiving single PRP or placebo injections., Methods: A double-blinded, randomized placebo-controlled trial was performed with three groups receiving either placebo injections (Normal Saline), one PRP injection followed by two placebo injections, or three PRP injections. Each injection was given one week apart. Outcomes were prospectively collected prior to intervention and then at six weeks, three months, six months, and 12 months post-intervention. Primary outcome measures were Knee Injury and Osteoarthritis Outcome Score (KOOS) and EuroQol five-dimension five-level index (EQ-5D-5L). Secondary outcomes included visual analogue scale for pain and patient subjective assessment of the injections., Results: A total of 102 patients were recruited. The follow-up period was 12 months, at intervals of six weeks, 12 weeks, six months, and 12 months. KOOS-Total significantly improved in all groups at these time intervals compared to pre-injection. There was an improvement in EQ-5D-5L index scores in saline and single injection groups, but not in the multiple injection group. Comparison of treatment groups showed no additional beneficial effect of single or multiple PRP injections above that displayed in the saline injection group. Subjective patient satisfaction and recommendation of treatment received demonstrated a similar pattern in all the groups. There was no indication of superiority of either single or multiple PRP injections compared to saline injections., Conclusion: There is no evidence that single or multiple PRP had any additional beneficial effect compared to saline injection up to 12 months, follow-up after treatment of early stage symptomatic OA of the knee. Cite this article: Bone Joint J 2022;104-B(6):663-671.
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- 2022
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37. Exploring the Alternative Model for Personality Disorders Using SCORS-G Ratings on Thematic Apperception Test Narratives.
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Ruchensky JR, Dowgwillo EA, Kelley SE, Massey C, Slavin-Mulford J, Richardson LA, Blais MA, and Stein MB
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- Diagnostic and Statistical Manual of Mental Disorders, Humans, Personality, Personality Assessment, Personality Disorders diagnosis, Personality Disorders psychology, Thematic Apperception Test
- Abstract
The Alternative Model for Personality Disorders (AMPD) in Section III of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5 ; American Psychiatric Association, 2013) conceptualizes personality pathology as a combination of impairment (Criterion A) and traits (Criterion B). One measure used to develop Criterion A was the Social Cognition and Object Relations Scale - Global Rating Method (SCORS-G), which is a multidimensional, object-relational clinician-rated measure of personality functioning. Although there are conceptual links between the AMPD and SCORS-G dimensions, there exists no research examining the relationship. To address this, we examined associations between the SCORS-G dimensions and measures of the AMPD constructs in a large, archival dataset of outpatients and inpatients. More pathological scores on SCORS-G dimensions reflecting self- and interpersonal functioning were associated with greater pathological traits and impairment. Overall, results support further investigation into SCORS-G as a useful measure in AMPD research and assessment.
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- 2022
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38. Surgical Plating vs Closed Reduction for Fractures in the Distal Radius in Older Patients: A Randomized Clinical Trial.
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Lawson A, Naylor JM, Buchbinder R, Ivers R, Balogh ZJ, Smith P, Xuan W, Howard K, Vafa A, Perriman D, Mittal R, Yates P, Rieger B, Smith G, Adie S, Elkinson I, Kim W, Sungaran J, Latendresse K, Wong J, Viswanathan S, Landale K, Drobetz H, Tran P, Page R, Beattie S, Mulford J, Incoll I, Kale M, Schick B, Li T, Higgs A, Oppy A, and Harris IA
- Subjects
- Age Factors, Aged, Aged, 80 and over, Australia, Cohort Studies, Female, Humans, Male, Middle Aged, New Zealand, Treatment Outcome, Bone Plates, Closed Fracture Reduction, Fracture Fixation, Internal, Radius Fractures surgery
- Abstract
Importance: The burden of injury and costs of wrist fractures are substantial. Surgical treatment became popular without strong supporting evidence., Objective: To assess whether current surgical treatment for displaced distal radius fractures provided better patient-reported wrist pain and function than nonsurgical treatment in patients 60 years and older., Design, Setting, and Participants: In this multicenter randomized clinical trial and parallel observational study, 300 eligible patients were screened from 19 centers in Australia and New Zealand from December 1, 2016, until December 31, 2018. A total of 166 participants were randomized to surgical or nonsurgical treatment and followed up at 3 and 12 months by blinded assessors. Those 134 individuals who declined randomization were included in a parallel observational cohort with the same treatment options and follow-up. The primary analysis was intention to treat; sensitivity analyses included as-treated and per-protocol analyses., Intervention: Surgical treatment was open reduction and internal fixation using a volar-locking plate (VLP). Nonsurgical treatment was closed reduction and cast immobilization (CR)., Main Outcomes and Measures: The primary outcome was the Patient-Rated Wrist Evaluation score at 12 months. Secondary outcomes were Disabilities of Arm, Shoulder, and Hand questionnaire score, health-related quality of life, pain, major complications, patient-reported treatment success, bother with appearance, and therapy use., Results: In the 300 study participants (mean [SD] age, 71.2 [7.5] years; 269 [90%] female; 166 [81 VLP and 85 CR] in the randomized clinical trial sample and 134 [32 VLP and 102 CR] in the observational sample), no clinically important between-group difference in 12-month Patient-Rated Wrist Evaluation scores (mean [SD] score of 19.8 [21.1] for VLP and 21.5 [24.3] for CR; mean difference, 1.7 points; 95% CI -5.4 to 8.8) was observed. No clinically important differences were found in quality of life, wrist pain, or bother at 3 and 12 months. No significant difference was found in total complications between groups (12 of 84 [14%] for the CR group vs 6 of 80 [8%] for the VLP group; risk ratio [RR], 0.53; 95% CI, 0.21-1.33). Patient-reported treatment success favored the VLP group at 12 months (very successful or successful: 70 [89%] vs 57 [70%]; RR, 1.26; 95% CI, 1.07-1.48; P = .005). There was greater use of postoperative physical therapy in the VLP group (56 [72%] vs 44 [54%]; RR, 1.32; 95% CI, 1.04-1.69; P = 0.02)., Conclusions and Relevance: This randomized clinical trial found no between-group differences in improvement in wrist pain or function at 12 months from VLP fixation over CR for displaced distal radius fractures in older people., Trial Registration: http://anzctr.org.au identifier: ACTRN12616000969460.
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- 2021
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39. A Combined Randomised and Observational Study of Surgery for Fractures In the distal Radius in the Elderly (CROSSFIRE): a statistical analyses plan.
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Lawson A, Naylor J, Buchbinder R, Ivers R, Balogh Z, Smith P, Mittal R, Xuan W, Howard K, Vafa A, Yates P, Rieger B, Smith G, Elkinson I, Kim W, Sungaran J, Latendresse K, Wong J, Viswanathan S, Landale K, Drobetz H, Tran P, Page R, Hau R, Mulford J, Incoll I, Kale M, Schick B, Higgs A, Oppy A, Perriman D, and Harris I
- Subjects
- Aged, Australia, Bone Plates, Female, Humans, Male, Observational Studies as Topic, Patient Reported Outcome Measures, Quality of Life, Randomized Controlled Trials as Topic, Selection Bias, Fracture Fixation, Internal, Radius surgery, Radius Fractures surgery, Radius Fractures therapy
- Abstract
Background: We are performing a combined randomised and observational study comparing internal fixation to non-surgical management for common wrist fractures in older patients. This paper describes the statistical analysis plan., Methods/design: A Combined Randomised and Observational Study of Surgery for Fractures In the distal Radius in the Elderly (CROSSFIRE) is a randomised controlled trial comparing two types of usual care for treating wrist fractures in older patients, surgical fixation using volar locking plates and non-surgical treatment using closed reduction and plaster immobilisation. The primary aim of this comparative-effectiveness study is to determine whether surgery is superior to non-surgical treatment with respect to patient-reported wrist function at 12 months post treatment. The secondary outcomes include radiographic outcomes, complication rates and patient-reported outcomes including quality of life, pain, treatment success and cosmesis. Primary analysis will use a two-sample t test and an intention-to-treat analysis using the randomised arm of the study. Statistical analyses will be two-tailed and significance will be determined by p < 0.05. Sensitivity analyses will be conducted to assess for differences in intention-to-treat, per-protocol and as-treated analyses. Sensitivity analyses will also be conducted to assess selection bias by evaluating differences in participants between the randomised and observational study arms, and for bias relating to any missing data. An economic analysis will be conducted separately if surgery is shown to provide superior outcomes to a level of clinical significance., Discussion: This statistical analysis plan describes the analysis of the CROSSFIRE study which aims to provide evidence to aid clinical decision-making in the treatment of distal radius fractures in older patients., Trial Registration: CROSSFIRE was approved by The Hunter New England Human Research Ethics Committee (HNEHREC Reference No: 16/02/17/3.04). Registered on 22 July 2016 with The Australian and New Zealand Clinical Trials Registry (ANZCTR Number; ACTRN12616000969460 ). This manuscript is based on v.11 of the statistical analysis plan. A copy of v.11, signed by the chief investigator and the senior statistician is kept at the administering institution.
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- 2020
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40. When's a story a story? Determining interpretability of Social Cognition and Object Relations Scale-Global ratings on Thematic Apperception Test narratives.
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Stein MB, Calderon S, Ruchensky J, Massey C, Slavin-Mulford J, Chung WJ, Richardson LA, and Blais MA
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- Adult, Female, Humans, Intelligence, Male, Psychopathology, Reproducibility of Results, Narration, Object Attachment, Social Cognition, Thematic Apperception Test
- Abstract
The Social Cognition and Object Relations Scale-Global Rating Method (SCORS-G) measures the quality of object relations in narrative material. The reliability and validity of this measure have been well established. However, a psychometric oddity of this scale is that default ratings are given to select dimensions when the relevant construct is not present. This can result in narrative 'blandness' and may impact clinical findings. The aim of these two studies is to understand these phenomena both psychometrically and clinically. In the first study, we identified 276 outpatients who had SCORS-G ratings for TAT Cards 1, 2, 3BM, and 14, set criteria for narrative 'blandness' across all eight dimensions, and examined group differences. In Study 2, we used a subset (N = 99) of Study 1 and examined how percentage of formal default ratings for Emotional Investment in Values and Moral Standards (EIM), Experience and Management of Aggressive Impulses (AGG), Self-Esteem(SE), and Identify and Coherence of Self (ICS) impacted robustness of correlations across tests of intelligence, psychopathology, and normal personality functioning. Taken together, we identified clinical characteristics of patients who are more likely to produce 'bland' narratives and increased percentages of formal default ratings. Also, an excess of default ratings per protocol impacts robustness of correlations and weakens significant correlations. As cut-off scores increase (>25% and >28.12%), the likelihood of being able to interpret EIM, AGG, SE, and ICS decreases. Psychometric and clinical implications are discussed., (© 2020 John Wiley & Sons, Ltd.)
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- 2020
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41. The relationship between trainee therapist traits with the use of self-disclosure and immediacy in psychotherapy.
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Jowers CE, Cain LA, Hoffman ZT, Perkey H, Stein MB, Widner SC, and Slavin-Mulford J
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- Adult, Female, Humans, Male, Prospective Studies, Young Adult, Professional-Patient Relations, Psychotherapy education, Self Disclosure, Training Support
- Abstract
The goal of the present study was to explore how self-disclosure (SD) and immediacy relate to trainee therapists' personal characteristics. A prospective multitrait multimethod assessment approach was utilized to assess a wide range of trainee characteristics at the beginning of graduate school. Results showed a significant, positive relationship between trainee interpersonal problems and SD for trainees ( n = 33) in their third psychotherapy session with their first patient. Moreover, greater use of SD correlated with less session depth, as rated by the trainee. Greater use of immediacy was positively related to trainee undergraduate grade point average and trainee-reported post-session arousal. Notably, all statistically significant findings had a moderate magnitude of effect. Finally, qualitative analyses of the SDs and immediacy statements were included to aid the discussion of potential reasons for the results. Overall, our findings provide preliminary conclusions about which trainees utilize SD and immediacy, what types of SDs and immediacy interventions they tend to use, and how trainees and patients perceived the session in which SD and immediacy were implemented. Implications for supervision and training are discussed. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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- 2019
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42. Diagnosis and management of chronic hip and knee pain in a Tasmanian orthopaedic clinic: a study assessing the diagnostic and treatment planning decisions of an advanced scope physiotherapist.
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Jovic D, Mulford J, Ogden K, and Zalucki N
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- Aged, Aged, 80 and over, Chronic Pain surgery, Clinical Competence statistics & numerical data, Conservative Treatment, Female, Hip Joint, Humans, Knee Joint, Male, Middle Aged, Orthopedic Surgeons, Orthopedics, Physical Therapy Modalities, Primary Health Care, Referral and Consultation, Tasmania, Treatment Outcome, Triage, Chronic Pain diagnosis, Chronic Pain therapy, Clinical Decision-Making methods, Joint Diseases diagnosis, Joint Diseases therapy, Physical Therapists statistics & numerical data
- Abstract
The aim of this study is to investigate the clinical effectiveness of an advanced practice physiotherapist triaging patients referred from primary care to the orthopaedic clinic with chronic hip and knee pain. An exploratory study design was used to assess 87 consecutive patients referred from general practice in Northern Tasmania. Patients were assessed by both an advanced practice physiotherapist and a consultant orthopaedic surgeon. Diagnostic and treatment decisions were compared, with the orthopaedic consultant decision defined as the gold standard. By using these decisions, over and under referral rates to orthopaedics could be calculated, as well as the surgical conversion rate. Conservative care of patients referred to the orthopaedic clinic with hip and knee pain was limited. The diagnostic agreement between the advanced scope physiotherapist and the orthopaedic surgeon was almost perfect (weighted kappa 0.93 (95% CI 0.87-1.00)), with treatment agreement substantial (weighted kappa 0.75 (95% CI 0.62-0.89)). Under a physiotherapist-led triage service, the surgical conversion rate doubled from 38% to 78%. An advanced physiotherapist assessing and treating patients with chronic hip and knee pain made decisions that match substantially with decisions made by an orthopaedic consultant. A model of care utilising an advanced physiotherapist in this way has the potential to support high-quality orthopaedic care in regional centres.
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- 2019
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43. You really are too kind: implications regarding friendly submissiveness in trainee therapists.
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Cain L, Perkey H, Widner S, Johnson JA, Hoffman Z, and Slavin-Mulford J
- Abstract
To facilitate patient growth, therapists must immerse themselves in the patient's world while also being able to see what is needed for change. This process requires finding a delicate balance between supporting and pushing patients. Therapists in training are additionally tasked with incorporating supervisors' suggestions with their own views on what is needed to help their patients. Beginning therapists with tendencies to be overly accommodating may struggle to reconcile these competing demands. Thus, the aim of the present work is to explore how trainee friendly submissiveness (FS) interfaces with psychotherapy. Prior to training, clinical graduate trainee ( n = 35) FS was assessed using the Inventory of Interpersonal Problems-32. Process and outcome data were then collected from each therapist's first training case. Specifically, each trainee was assigned an undergraduate student volunteer with whom they had four non-manualized therapy sessions over the academic semester. After the third session, patients and trainees completed questionnaires assessing session impact and the working alliance, and two expert raters coded third session videotapes for techniques. Following termination, patients rated the overall helpfulness of the therapy. Trainee FS was significantly negatively associated with patient-rated depth, alliance, and overall helpfulness with moderate effects. Findings from a mediation analysis further suggested that trainees with higher FS struggled to focus the therapy in a way that felt productive to patients. Implications for clinical training are discussed., Competing Interests: Conflict of interest: the authors report grants from Society for Psychotherapy Research, grants from American Psychological Association, Division 29, during the conduct of the study., (©Copyright L. Cain et al., 2018.)
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- 2018
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44. Improving physical activity, pain and function in patients waiting for hip and knee arthroplasty by combining targeted exercise training with behaviour change counselling: study protocol for a randomised controlled trial.
- Author
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O'Brien J, Hamilton K, Williams A, Fell J, Mulford J, Cheney M, Wu S, and Bird ML
- Subjects
- Arthralgia diagnosis, Arthralgia physiopathology, Arthralgia surgery, Biomechanical Phenomena, Health Behavior, Health Knowledge, Attitudes, Practice, Hip Joint physiopathology, Humans, Knee Joint physiopathology, Osteoarthritis, Hip diagnosis, Osteoarthritis, Hip physiopathology, Osteoarthritis, Hip surgery, Osteoarthritis, Knee diagnosis, Osteoarthritis, Knee physiopathology, Osteoarthritis, Knee surgery, Pain Measurement, Randomized Controlled Trials as Topic, Recovery of Function, Tasmania, Time Factors, Treatment Outcome, Arthralgia therapy, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Behavior Therapy methods, Counseling methods, Exercise Therapy methods, Hip Joint surgery, Knee Joint surgery, Osteoarthritis, Hip therapy, Osteoarthritis, Knee therapy, Waiting Lists
- Abstract
Background: Osteoarthritis often results in prolonged periods of reduced physical activity and is associated with adverse health outcomes, including increased risk of cardiovascular and metabolic diseases. Exercise interventions for patients on the waiting list for arthroplasty can reduce the risk of long-term adverse outcomes by increasing activity levels. However, uptake and ongoing positive rates of physical activity in this population are low and the impact of pre-operative behaviour counselling on exercise is not known., Method/design: The exercise and behaviour change counselling (ENHANCE) trial is a two-arm assessor-blind randomised controlled trial to assess the effectiveness of a 12-week exercise intervention designed to improve long-term physical activity and functional abilities for people awaiting arthroplasty. Participants on the waiting list for hip and knee arthroplasty are recruited from one clinical site in Australia. After collection of baseline data, participants are randomised to either an intervention or control group. The control group receive usual care, as recommended by evidence-based guidelines. The intervention group receive an individualised programme of exercises and counselling sessions. The 12-week exercise programme integrates multiple elements, including up to five in-person counselling sessions, supported by written materials. Participants are encouraged to seek social support among their friends and self-monitor their physical activity. The primary outcome is physical activity (daily step count and percentage of day spent in sedentary activities). Secondary outcomes include pain ratings, physical function, psychosocial factors and changes in clinical markers linked with potential common chronic diseases (diabetes and cardiovascular disease). All outcomes are assessed at baseline and 26 weeks later and again at 26 weeks post-surgery., Discussion: This study seeks to address a significant gap in current osteoarthritis management practice by providing evidence for the effectiveness of an exercise programme combined with behaviour counselling for adults waiting for hip and knee arthroplasty. Theory-driven evidence-based strategies that can improve an individual's exercise self-efficacy and self-management capacity could have a significant impact on the development of secondary chronic disease in this population. Information gained from this study will contribute to the evidence base on the management of adults waiting for hip and knee arthroplasty., Trial Registration: Australian New Zealand Clinical Trials Registry, ACTRN12617000357358 . Registered on 8 March 2017.
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- 2018
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45. Exploring the Factor Structure of the Social Cognition and Object Relations-Global Rating Method: Support for Two- and Three-Factor Models.
- Author
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Siefert CJ, Stein M, Slavin-Mulford J, Haggerty G, Sinclair SJ, Funke D, and Blais MA
- Subjects
- Adult, Factor Analysis, Statistical, Female, Humans, Inpatients, Male, Outpatients, Psychometrics, Thematic Apperception Test, Cognition, Narration, Object Attachment, Social Behavior
- Abstract
The Social Cognition and Object Relations Scales-Global Rating Method (SCORS-G) contains 8 scales for coding narrative content. This study explores the factor structure of this measure using college (n = 171), outpatient (n = 239), and inpatient (n = 78) samples. Participants told stories to the Thematic Apperception Test (TAT; Murray, 1943) cards. Stories were transcribed and coded by blind raters using the SCORS-G. Cases were randomly assigned to an exploratory or validation group. Exploratory factor analysis with the exploratory group suggested 2- and 3-factor models. The Emotional Investment in Relationships (EIR) scale did not obtain a primary loading on any factor and was not included in subsequentmodels. After modifications, confirmatory factor analysis indicated good-to-adequate fit for 2- and 3-factor models. Both models showed good fit in the validation group and met criteria for invariance across models. Findings indicated that some SCORS-G scales tap cognitive-structural elements, whereas others assess affective-relational components of narratives. We found mild support separating the affective-relational scales in terms of internal representations for the self and others and relationships. The results reported here indicate that clinicians and researchers can calculate a separate cognitive-structural composite score and an affective-relational composite score when using the SCORS-G to rate TAT stories.
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- 2018
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46. Extending the Use of the SCORS-G Composite Ratings in Assessing Level of Personality Organization.
- Author
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Stein MB, Slavin-Mulford J, Sinclair SJ, Chung WJ, Roche M, Denckla C, and Blais MA
- Subjects
- Adult, Female, Humans, Male, Middle Aged, Narration, Personality Disorders psychology, Retrospective Studies, Self-Control, Social Behavior, Thematic Apperception Test, Interpersonal Relations, Personality Assessment
- Abstract
The Social Cognition and Object Relations Scale-Global Rating Method (SCORS-G; Stein, Hilsenroth, Slavin-Mulford, & Pinsker, 2011 ; Westen, 1995b ) reliably measures the quality of object relations in narrative material. It assesses 8 dimensions (on a continuum from maladaptive to adaptive) that mediate interpersonal functioning. The 8 dimensions can be averaged to create a global or composite score to represent a person's overall object relational functioning. This study aimed to create levels of personality organization using the SCORS-G global score ratings of Thematic Apperception Test (TAT) narratives and to explore the construct validity of these levels using a multimethod approach (i.e., psychopathology, normal personality, and life-event data). Meaningful relationships were found between the SCORS-G level of personality organization and aspects of psychopathology (Personality Assessment Inventory; Morey, 1991 ), regulation and control (NEO Five-Factor Inventory; Costa & McCrae, 1989, 1992b ), and number of psychiatric hospitalizations, suicide attempts, and educational level. Overall, this study demonstrates the potential value of creating levels of personality organization (LPO) using the SCORS-G composite or global ratings as a supplement to the psychological assessment process and further highlights the utility of this measure in the field of personality assessment. Clinical and research-related implications as well as limitations are discussed.
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- 2018
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47. External validity of the Psychiatric Diagnostic Screening Questionnaire (PDSQ) in a clinical sample.
- Author
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Perkey H, Sinclair SJ, Blais M, Stein MB, Neal P, Pierson AD, and Slavin-Mulford J
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Employment psychology, Female, Humans, Male, Middle Aged, Reproducibility of Results, Suicide, Attempted psychology, Young Adult, Mental Disorders diagnosis, Mental Disorders psychology, Personality Assessment standards, Psychiatric Status Rating Scales standards, Surveys and Questionnaires standards
- Abstract
This study contributes to the convergent and discriminant validity of the Psychiatric Diagnostic Screening Questionnaire (PDSQ) by investigating its correlations with the relevant clinical scales of the Personality Assessment Inventory (PAI) and life space variables, such as relationship status, education level, job loss, and history of suicide attempts. Bivariate correlations were calculated for a sample of 254 psychiatric outpatients. The results indicated that the PDSQ scales demonstrated good to excellent convergent and discriminant validity with target scales from the PAI. They were also found to be meaningfully associated with a variety of life space variables. For example, five of the subscales and the Total Score correlated positively with a recent job loss, and eight of the subscales were negatively associated with education and/or employment status. Some incongruence with hypothesized relationships was discovered for life correlates classified as markers of psychiatric severity. Overall, these findings add to the emerging body of evidence corroborating the convergent and discriminant validity of the PDSQ., (Copyright © 2017 Elsevier B.V. All rights reserved.)
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- 2018
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48. A combined randomised and observational study of surgery for fractures in the distal radius in the elderly (CROSSFIRE)-a study protocol.
- Author
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Harris IA, Naylor JM, Lawson A, Buchbinder R, Ivers R, Balogh Z, Smith P, Mittal R, Xuan W, Howard K, Vafa A, Yates P, Rieger B, Smith G, Elkinson I, Kim W, Chehade M, Sungaran J, Latendresse K, Wong J, Viswanathan S, Richardson M, Shrestha K, Drobetz H, Tran P, Loveridge J, Page R, Hau R, Bingham R, Mulford J, and Incoll I
- Subjects
- Aged, Aged, 80 and over, Australia, Bone Plates statistics & numerical data, Disability Evaluation, Female, Fractures, Bone rehabilitation, Humans, Male, Middle Aged, Pain Measurement, Physical Therapy Modalities, Quality of Life, Research Design, Treatment Outcome, Fracture Fixation, Internal methods, Fractures, Bone surgery, Radius physiopathology, Radius surgery
- Abstract
Fractures of the distal radius are common and occur in all age groups. The incidence is high in older populations due to osteoporosis and increased falls risk. Considerable practice variation exists in the management of distal radius fractures in older patients ranging from closed reduction with cast immobilisation to open reduction with plate fixation. Plating is currently the most common surgical treatment. While there is evidence showing no significant advantage for some forms of surgical fixation over conservative treatment, and no difference between different surgical techniques, there is a lack of evidence comparing two of the most common treatments used: closed reduction and casting versus plating. Surgical management involves significant costs and risks compared with conservative management. High-level evidence is required to address practice variation, justify costs and to provide the best clinical outcomes for patients., Methods and Analysis: This pragmatic, multicentre randomised comparative effectiveness trial aims to determine whether plating leads to better pain and function and is more cost-effective than closed reduction and casting of displaced distal radius fractures in adults aged 60 years and older. The trial will compare the two techniques but will also follow consenting patients who are unwilling to be randomised in a separate, observational cohort. Inclusion of non-randomised patients addresses selection bias, provides practice and outcome insights about standard care, and improves the generalisability of the results from the randomised trial., Ethics and Dissemination: CROSSFIRE(Combined Randomised and Observational Study of Surgery for Fractures In the distal Radius in the Elderly) was reviewed and approved by The Hunter New England HREC (HNEHREC Reference No: 16/02/17/3.04). The results of the trial will be published in a peer-reviewed journal and will be disseminated via various forms of media. Results will be incorporated in clinical recommendations and practice guidelines produced by professional bodies., Registration: CROSSFIRE has been registered with the Australian and New Zealand Clinical Trials Registry (ANZCTR: ACTRN12616000969460)., Competing Interests: Competing interests: All authors have completed the ICMJE COI form. Completed forms are held by the corresponding author. There were no COIs declared by any of the authors., (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)
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- 2017
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49. Estimating the Effects of Thematic Apperception Test Card Content on SCORS-G Ratings: Replication With a Nonclinical Sample.
- Author
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Siefert CJ, Stein MB, Slavin-Mulford J, Sinclair SJ, Haggerty G, and Blais MA
- Subjects
- Adult, Analysis of Variance, Female, Humans, Personality Assessment, Pregnancy, Reproducibility of Results, Young Adult, Thematic Apperception Test
- Abstract
The content of Thematic Apperception Test (TAT) cards can, in some cases, influence how respondents form narratives. This study examines how imagery from select TAT cards affects the narratives of respondents from a nonclinical setting. The Social Cognition and Object Relations Scale-Global Rating Method (SCORS-G; Stein, Hilsenroth, Slavin-Mulford, & Pinsker, 2011 ; Westen, Lohr, Silk, Kerber, & Goodrich, 1989) was used to rate narratives. Forty-nine college students provided narratives to 6 TAT cards. Narratives were rated by two expert raters using the SCORS-G. Consistent with prior research, Card 2 exhibited the most pull for adaptive ratings on SCORS-G scales, and 3 BM exhibited the most pull for maladaptive ratings. Findings for other cards were mixed. Although raters were highly reliable, internal consistency estimates were lower than desirable for 6 of the 8 SCORS-G scales. Variance component estimates indicated that card by person interactions accounted for the largest amount of variance in person-level scores. Results and limitations are discussed in light of prior research. We also make suggestions for further lines of research in this area.
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- 2016
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50. Response to Re: Short-term outcomes of local infiltration anaesthetic in total knee arthroplasty: a randomized controlled double-blinded controlled trial.
- Author
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Mulford J
- Subjects
- Double-Blind Method, Humans, Pain Measurement, Pain, Postoperative, Anesthetics, Local, Arthroplasty, Replacement, Knee
- Published
- 2016
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