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Your search keyword '"Mulders, Jaimie"' showing total 3 results
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3 results on '"Mulders, Jaimie"'

2. Digital holographic imaging as a method for quantitative, live cell imaging of drug response to novel targeted cancer therapies

Author

Croft, Laura, Mulders, Jaimie, Richard, Derek, O'Byrne, Ken, Croft, Laura, Mulders, Jaimie, Richard, Derek, and O'Byrne, Ken

Abstract

Digital holographic imaging (DHI) is a noninvasive, live cell imaging technique that enables long-term quantitative visualization of cells in culture. DHI uses phase-shift imaging to monitor and quantify cellular events such as cell division, cell death, cell migration, and drug responses. In recent years, the application of DHI has expanded from its use in the laboratory to the clinical setting, and currently it is being developed for use in theranostics. Here, we describe the use of the DHI platform HoloMonitorM4 to evaluate the effects of novel, targeted cancer therapies on cell viability and proliferation using the HeLa cancer cell line as a model. We present single cell tracking and population-wide analysis of multiple cell morphology parameters.

Published
2019

3. Digital Holographic Imaging as a Method for Quantitative, Live Cell Imaging of Drug Response to Novel Targeted Cancer Therapies.

Author

Croft LV, Mulders JA, Richard DJ, and O'Byrne K

Subjects
Antineoplastic Agents therapeutic use, Apoptosis drug effects, Cell Movement drug effects, Cell Survival drug effects, Drug Screening Assays, Antitumor instrumentation, Drug Screening Assays, Antitumor methods, HeLa Cells, Holography instrumentation, Humans, Intravital Microscopy instrumentation, Microscopy, Phase-Contrast instrumentation, Microscopy, Phase-Contrast methods, Molecular Targeted Therapy methods, Neoplasms pathology, Theranostic Nanomedicine methods, Antineoplastic Agents pharmacology, Holography methods, Intravital Microscopy methods, Neoplasms drug therapy
Abstract

Digital holographic imaging (DHI) is a noninvasive, live cell imaging technique that enables long-term quantitative visualization of cells in culture. DHI uses phase-shift imaging to monitor and quantify cellular events such as cell division, cell death, cell migration, and drug responses. In recent years, the application of DHI has expanded from its use in the laboratory to the clinical setting, and currently it is being developed for use in theranostics. Here, we describe the use of the DHI platform HoloMonitorM4 to evaluate the effects of novel, targeted cancer therapies on cell viability and proliferation using the HeLa cancer cell line as a model. We present single cell tracking and population-wide analysis of multiple cell morphology parameters.

Published
2019
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