1,621 results on '"Mulder E"'
Search Results
2. Safe Stop IPI-NIVO trial: early discontinuation of nivolumab upon achieving a complete or partial response in patients with irresectable stage III or metastatic melanoma treated with first-line ipilimumab-nivolumab – study protocol
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Janssen, J. C., van Dijk, B., de Joode, K., Aarts, M. J. B., van den Berkmortel, F. W. P. J., Blank, C. U., Boers-Sonderen, M. J., van den Eertwegh, A. J. M., de Groot, J. W. B., Jalving, M., de Jonge, M. J. A., Joosse, A., Kapiteijn, E., Kamphuis-Huismans, A. M., Naipal, K. A. T., Piersma, D., Rikhof, B., Westgeest, H. M., Vreugdenhil, G., Oomen-de Hoop, E., Mulder, E. E. A. P., and van der Veldt, Astrid A. M.
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- 2024
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3. Daily artificial gravity partially mitigates vestibular processing changes associated with head-down tilt bedrest
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Tays, G. D., Hupfeld, K. E., McGregor, H. R., Beltran, N. E., De Dios, Y. E., Mulder, E., Bloomberg, J. J., Mulavara, A. P., Wood, S. J., and Seidler, R. D.
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- 2024
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4. Apertif, Phased Array Feeds for the Westerbork Synthesis Radio Telescope
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van Cappellen, W. A., Oosterloo, T. A., Verheijen, M. A. W., Adams, E. A. K., Adebahr, B., Braun, R., Hess, K. M., Holties, H., van der Hulst, J. M., Hut, B., Kooistra, E., van Leeuwen, J., Loose, G. M., Morganti, R., Moss, V. A., Orrú, E., Ruiter, M., Schoenmakers, A. P., Vermaas, N. J., Wijnholds, S. J., van Amesfoort, A. S., Arts, M. J., Attema, J. J., Bakker, L., Bassa, C. G., Bast, J. E., Benthem, P., Beukema, R., Blaauw, R., de Blok, W. J. G., Bouwhuis, M., Brink, R. H. van den, Connor, L., Coolen, A. H. W. M., Damstra, S., van Diepen, G. N. J., de Goei, R., Dénes, H., Drost, M., Ebbendorf, N., Frank, B. S., Gardenier, D. W., Gerbers, M., Grange, Y. G., Grit, T., Gunst, A. W., Gupta, N., Ivashina, M. V., Józsa, G. I. G., Janssen, G. H., Koster, A., Kruithof, G. H., Kuindersma, S. J., Kutkin, A., Lucero, D. M., Maan, Y., Maccagni, F. M., van der Marel, J., Mika, A., Morawietz, J., Mulder, H., Mulder, E., Norden, M. J., Offringa, A. R., Oostrum, L. C., Overeem, R. E., Paragi, Z., Pepping, H. J., Petroff, E., Pisano, D. J., Polatidis, A. G., Prasad, P., de Reijer, J. P. R., Romein, J. W., Schaap, J., Schoonderbeek, G. W., Schulz, R., van der Schuur, D., Sclocco, A., Sluman, J. J., Smits, R., Stappers, B. W., Straal, S. M., Stuurwold, K. J. C., Verstappen, J., Vohl, D., Wierenga, K. J., Woestenburg, E. E. M., Zanting, A. W., and Ziemke, J.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We describe the APERture Tile In Focus (Apertif) system, a phased array feed (PAF) upgrade of the Westerbork Synthesis Radio Telescope which has transformed this telescope into a high-sensitivity, wide field-of-view L-band imaging and transient survey instrument. Using novel PAF technology, up to 40 partially overlapping beams can be formed on the sky simultaneously, significantly increasing the survey speed of the telescope. With this upgraded instrument, an imaging survey covering an area of 2300 deg2 is being performed which will deliver both continuum and spectral line data sets, of which the first data has been publicly released. In addition, a time domain transient and pulsar survey covering 15,000 deg2 is in progress. An overview of the Apertif science drivers, hardware and software of the upgraded telescope is presented, along with its key performance characteristics., Comment: 29 pages, 42 figures, accepted for publication by A&A
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- 2021
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5. Effects of daily artificial gravity training on orthostatic tolerance following 60-day strict head-down tilt bedrest
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Hoenemann, J.-N., Moestl, S., van Herwaarden, A. E., Diedrich, A., Mulder, E., Frett, T., Petrat, G., Pustowalow, W., Arz, M., Heusser, K., Lee, S., Jordan, J., Tank, J., and Hoffmann, F.
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- 2023
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6. GP consultations for menstrual disorders after COVID-19 vaccination – A self-controlled cohort study based on routine healthcare data from the Netherlands
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Jajou, R., Lieber, T., van Puijenbroek, E.P., Mulder, E., Overbeek, J., Hek, K., van Hunsel, F.P.A.M., and Kant, A.
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- 2024
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7. External validation of the PAGE-B score for HCC risk prediction in people living with HIV/HBV coinfection
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Abela, I., Aebi-Popp, K., Anagnostopoulos, A., Battegay, M., Bernasconi, E., Braun, D.L., Bucher, H.C., Calmy, A., Cavassini, M., Ciuffi, A., Dollenmaier, G., Egger, M., Elzi, L., Fehr, J., Fellay, J., Furrer, H., Fux, C.A., Günthard, H.F., Hachfeld, A., Haerry, D., Hasse, B., Hirsch, H.H., Hoffmann, M., Hösli, I., Huber, M., Jackson-Perry, D., Kahlert, C.R., Kaiser, L., Keiser, O., Klimkait, T., Kouyos, R.D., Kovari, H., Kusejko, K., Labhardt, N., Leuzinger, K., de Tejada B, Martinez, Marzolini, C., Metzner, K.J., Müller, N., Nemeth, J., Nicca, D., Notter, J., Paioni, P., Pantaleo, G., Perreau, M., Rauch, A., Salazar-Vizcaya, L., Schmid, P., Speck, R., Stöckle, M., Tarr, P., Trkola, A., Wandeler, G., Weisser, M., Yerly, S., van der Valk, M., Geerlings, S.E., Goorhuis, A., Harris, V.C., Hovius, J.W., Lempkes, B., Nellen, F.J.B., van der Poll, T., Prins, J.M., Spoorenberg, V., van Vugt, M., Wiersinga, W.J., Wit, F.W.M.N., Bruins, C., van Eden, J., Hylkema-van den Bout, I.J., van Hes, A.M.H., Pijnappel, F.J.J., Smalhout, S.Y., Weijsenfeld, A.M., Back, N.K.T., Berkhout, B., Cornelissen, M.T.E., van Houdt, R., Jonges, M., Jurriaans, S., Schinkel, C.J., Wolthers, K.C., Zaaijer, H.L., Peters, E.J.G., van Agtmael, M.A., Autar, R.S., Bomers, M., Sigaloff, K.C.E., Heitmuller, M., Laan, L.M., van den Berge, M., Stegeman, A., Baas, S., Hage de Looff, L., van Arkel, A., Stohr, J., Wintermans, B., Pronk, M.J.H., Ammerlaan, H.S.M., de Munnik, E.S., Deiman, B., Jansz, A.R., Scharnhorst, V., Tjhie, J., Wegdam, M.C.A., van Eeden, A., Hoornenborg, E., Nellen, J., Alers, W., Elsenburg, L.J.M., Nobel, H., van Kasteren, M.E.E., Berrevoets, M.A.H., Brouwer, A.E., de Kruijf-van de Wiel, B.A.F.M., Adams, A., Rijkevoorsel, M. Pawels-van, Buiting, A.G.M., Murck, J.L., Rokx, C., Anas, A.A., Bax, H.I., van Gorp, E.C.M., de Mendonça Melo, M., van Nood, E., Nouwen, J.L., Rijnders, B.J.A., Schurink, C.A.M., Slobbe, L., de Vries-Sluijs, T.E.M.S., Bassant, N., van Beek, J.E.A., Vriesde, M., van Zonneveld, L.M., de Groot, J., van Kampen, J.J.A., Koopmans, M.P.G., Rahamat-Langendoen, J.C., Branger, J., Douma, R.A., Cents-Bosma, A.S., Duijf-van de Ven, C.J.H.M., Schippers, E.F., van Nieuwkoop, C., Geilings, J., van Winden, S., van der Hut, G., van Burgel, N.D., Leyten, E.M.S., Gelinck, L.B.S., Mollema, F., Wildenbeest, G.S., Nguyen, T., Groeneveld, P.H.P., Bouwhuis, J.W., Lammers, A.J.J., van Hulzen, A.G.W., Kraan, S., Kruiper, M.S.M., van der Bliek, G.L., Bor, P.C.J., Debast, S.B., Wagenvoort, G.H.J., Roukens, A.H.E., de Boer, M.G.J., Jolink, H., Lambregts, M.M.C., Scheper, H., Dorama, W., van Holten, N., Claas, E.C.J., Wessels, E., Hollander, J.G. den, El Moussaoui, R., Pogany, K., Brouwer, C.J., Heida-Peters, D., Mulder, E., Smit, J.V., Struik-Kalkman, D., van Niekerk, T., Pontesilli, O., van Tienen, C., Lowe, S.H., Lashof, A.M.L. Oude, Posthouwer, D., van Wolfswinkel, M.E., Ackens, R.P., Burgers, K., Elasri, M., Schippers, J., Havenith, T.R.A., van Loo, M., van Vonderen, M.G.A., Kampschreur, L.M., van Broekhuizen, M.C., S, Faber, Al Moujahid, A., Kootstra, G.J., Delsing, C.E., van der Burg-van de Plas, M., Scheiberlich, L., Kortmann, W., van Twillert, G., Renckens, R., Wagenaar, J., Ruiter-Pronk, D., van Truijen-Oud, F.A., Stuart, J.W.T. Cohen, Hoogewerf, M., Rozemeijer, W., Sinnige, J.C., Brinkman, K., van den Berk, G.E.L., Lettinga, K.D., de Regt, M., Schouten, W.E.M., Stalenhoef, J.E., Veenstra, J., Vrouenraets, S.M.E., Blaauw, H., Geerders, G.F., Kleene, M.J., Knapen, M., Kok, M., van der Meché, I.B., Toonen, A.J.M., Wijnands, S., Wttewaal, E., Kwa, D., van de Laar, T.J.W., van Crevel, R., van Aerde, K., Dofferhoff, A.S.M., Henriet, S.S.V., Hofstede, H.J.M. ter, Hoogerwerf, J., Richel, O., Albers, M., Grintjes-Huisman, K.J.T., de Haan, M., Marneef, M., McCall, M., Burger, D., Gisolf, E.H., Claassen, M., Hassing, R.J., Beest, G. ter, van Bentum, P.H.M., Gelling, M., Neijland, Y., Swanink, C.M.A., Velderman, M. Klein, van Lelyveld, S.F.L., Soetekouw, R., van der Prijt, L.M.M., van der Swaluw, J., Kalpoe, J.S., Wagemakers, A., Vahidnia, A., Lauw, F.N., Verhagen, D.W.M., van Wijk, M., Bierman, W.F.W., Bakker, M., van Bentum, R.A., van den Boomgaard, M.A., Kleinnijenhuis, J., Kloeze, E., Middel, A., Postma, D.F., Schenk, H.M., Stienstra, Y., Wouthuyzen-Bakker, M., Boonstra, A., de Jonge, H., Maerman, M.M.M., de Weerd, D.A., van Eije, K.J., Knoester, M., van Leer-Buter, C.C., Niesters, H.G.M., T.Mudrikova, Barth, R.E., Bruns, A.H.W., Ellerbroek, P.M., Hensgens, M.P.M., Oosterheert, J.J., Schadd, E.M., Verbon, A., van Welzen, B.J., Berends, H., Santen, B.M.G. Griffioen-van, de Kroon, I., Lunel, F.M. Verduyn, Wensing, A.M.J., Zaheri, S., Boyd, A.C., Bezemer, D.O., van Sighem, A.I., Smit, C., Hillebregt, M.M.J., Woudstra, T.J., Rutkens, T., Bergsma, D., Brétin, N.M., Lelivelt, K.J., van de Sande, L., van der Vliet, K.M. Visser.S.T., Paling, F., de Groot-Berndsen, L.G.M., van den Akker, M., Alexander, R., Bakker, Y., El Berkaoui, A., Bezemer-Goedhart, M., Djoechro, E.A., Groters, M., Koster, L.E., Lodewijk, C.R.E., Lucas, E.G.A., Munjishvili, L., Peeck, B.M., Ree, C.M.J., Regtop, R., van Rijk, A.F., Ruijs-Tiggelman, Y.M.C., Schnörr, P.P., Schoorl, M.J.C., Tuijn, E.M., Veenenberg, D.P., Witte, E.C.M., Bretin, N.M., Karpov, I., Losso, M., Lundgren, J., Rockstroh, J., Aho, I., Rasmussen, L.D., Novak, P., Pradier, C., Chkhartishvili, N., Matulionyte, R., Oprea, C., Kowalska, J.D., Begovac, J., Miró, J.M., Guaraldi, G., Paredes, R., Peters, L., Larsen, J.F., Neesgaard, B., Jaschinski, N., Fursa, O., Raben, D., Kristensen, D., Fischer, A.H., Jensen, S.K., Elsing, T.W., Gardizi, M., Mocroft, A., Phillips, A., Reekie, J., Cozzi-Lepri, A., Pelchen-Matthews, A., Roen, A., Tusch, E.S., Bannister, W., Bellecave, P., Blanco, P., Bonnet, F., Bouchet, S., Breilh, D., Cazanave, C., Desjardin, S., Gaborieau, V., Gimbert, A., Hessamfar, M., Lacaze-Buzy, L., Lacoste, D., Lafon, M.E., Lazaro, E., Leleux, O., Le Marec, F., Le Moal, G., Malvy, D., Marchand, L., Mercié, P., Neau, D., Pellegrin, I., Perrier, A., Petrov-Sanchez, V., Vareil, M.O., Wittkop, L., Bernard, N., Chaussade, D. Bronnimann H., Dondia, D., Duffau, P., Faure, I., Morlat, P., Mériglier, E., Paccalin, F., Riebero, E., Rivoisy, C., Vandenhende, M.A., Barthod, L., Dauchy, F.A., Desclaux, A., Ducours, M., Dutronc, H., Duvignaud, A., Leitao, J., Lescure, M., Nguyen, D., Pistone, T., Puges, M., Wirth, G., Courtault, C., Camou, F., Greib, C., Pellegrin, J.L., Rivière, E., Viallard, J.F., Imbert, Y., Thierry-Mieg, M., Rispal, P., Caubet, O., Ferrand, H., Tchamgoué, S., Farbos, S., Wille, H., Andre, K., Caunegre, L., Gerard, Y., Osorio-Perez, F., Chossat, I., Iles, G., Labasse-Depis, M., Lacassin, F., Barret, A., Castan, B., Koffi, J., Rouanes, N., Saunier, A., Zabbe, J.B., Dumondin, G., Beraud, G., Catroux, M., Garcia, M., Giraud, V., Martellosio, J.P., Roblot, F., Pasdeloup, T., Riché, A., Grosset, M., Males, S., Bell, C. Ngo, Carpentier, C., Bellecave, Virology P., Tumiotto, C., Miremeont-Salamé, G., Arma, D., Arnou, G., Blaizeau, M.J., Camps, P., Decoin, M., Delveaux, S., Diarra, F., Gabrea, L., Lawson-Ayayi, S., Lenaud, E., Plainchamps, D., Pougetoux, A., Uwamaliya, B., Zara, K., Conte, V., Gapillout, M., Surial, Bernard, Ramírez Mena, Adrià, Roumet, Marie, Limacher, Andreas, Smit, Colette, Leleux, Olivier, Mocroft, Amanda, van der Valk, Marc, Bonnet, Fabrice, Peters, Lars, Rockstroh, Jürgen K., Günthard, Huldrych F., Berzigotti, Annalisa, Rauch, Andri, and Wandeler, Gilles
- Published
- 2023
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8. SPHERE / ZIMPOL high resolution polarimetric imager. I. System overview, PSF parameters, coronagraphy, and polarimetry
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Schmid, H. M., Bazzon, A., Roelfsema, R., Mouillet, D., Milli, J., Menard, F., Gisler, D., Hunziker, S., Pragt, J., Dominik, C., Boccaletti, A., Ginski, C., Abe, L., Antoniucci, S., Avenhaus, H., Baruffolo, A., Baudoz, P., Beuzit, J. L., Carbillet, M., Chauvin, G., Claudi, R., Costille, A., Daban, J. B., de Haan, M., Desidera, S., Dohlen, K., Downing, M., Elswijk, E., Engler, N., Feldt, M., Fusco, T., Girard, J. H., Gratton, R., Hanenburg, H., Henning, Th., Hubin, N., Joos, F., Kasper, M., Keller, C. U., Langlois, M., Lagadec, E., Martinez, P., Mulder, E., Pavlov, A., Podio, L., Puget, P., Quanz, S., Rigal, F., Salasnich, B., Sauvage, J. F., Schuil, M., Siebenmorgen, R., Sissa, E., Snik, F., Suarez, M., Thalmann, Ch., Turatto, M., Udry, S., van Duin, A., van Holstein, R., Vigan, A., and Wildi, F.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We describe the Zurich Imaging Polarimeter (ZIMPOL), the visual focal plane subsystem of the SPHERE "VLT planet finder", which pushes the limits of current AO systems to shorter wavelengths, higher spatial resolution, and much improved polarimetric performance. We provide new benchmarks for the performance of high contrast instruments, in particular for polarimetric differential imaging. We have analyzed SPHERE/ZIMPOL point spread functions and measure the peak surface brightness, the encircled energy, and the full width half maximum (FWHM) for different wavelengths, atmospheric conditions, star brightness, and instrument modes. Coronagraphic images are described and analized and the performance for different coronagraphs is compared with tests for the binary alpha Hyi with a separation of 92 mas and a contrast of 6 mag. For the polarimetric mode we made the instrument calibrations using zero polarization and high polarization standard stars and here we give a recipe for the absolute calibration of polarimetric data. The data show a small <1 mas but disturbing differential polarimetric beam shifts, which can be explained as Goos-H\"ahnchen shifts from the inclined mirrors, and we discuss how to correct this effect. The polarimetric sensitivity is investigated with non-coronagraphic and deep, coronagraphic observations of the dust scattering around the symbiotic Mira variable R Aqr. SPHERE/ZIMPOL achieves imaging performances in the visual range with unprecedented characteristics, in particular very high spatial resolution and very high polarimetric contrast. This instrument opens up many new research opportunities for the detailed investigation of circumstellar dust, in scattered and therefore polarized light, for the investigation of faint companions, and for the mapping of circumstellar Halpha emission., Comment: 38 pages with 33 figurs, accepted for publication in Astron. Astrophys
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- 2018
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9. Real-world effectiveness and tolerability of switching to doravirine-based antiretroviral therapy in people with HIV: a nationwide, matched, prospective cohort study
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Oomen, Patrick G A, Wit, Ferdinand W N M, Brinkman, Kees, Vrouenraets, Saskia M E, Mudrikova, Tania, van Welzen, Berend J, van der Valk, Marc, van Agtmael, M.A., Bomers, M., Geerlings, S.E., Goorhuis, A., Harris, V.C., Hovius, J.W., Lemkes, B., Nellen, F.J.B., Peters, E.J.G., van der Poll, T., Prins, J.M., Sigaloff, K.C.E., Spoorenberg, V., van Vugt, M., Wiersinga, W.J., Bruins, C., van Eden, J., Hylkema-van den Bout, I.J., Laan, L.M., Pijnappel, F.J.J., Smalhout, S.Y., Spelbrink, M.E., Weijsenfeld, A.M., Back, N.K.T., Cornelissen, M.T.E., van Houdt, R., Jonges, M., Jurriaans, S., Schinkel, C.J., Welkers, M.R.A., Wolthers, K.C., van den Berge, M., Stegeman, A., Baas, S., Hage de Looff, L., van Arkel, A., Stohr, J., Wintermans, B., Pronk, M.J.H., Ammerlaan, H.S.M., de Bree, C., de Munnik, E.S., Phaf, S., Deiman, B., Jansz, A.R., Scharnhorst, V., Tjhie, J., Wegdam, M.C.A., Nellen, J., van Eeden, A., Hoornenborg, E., de Stoppelaar, S., Alers, W., Elsenburg, L.J.M., Nobel, H., Schinkel, C.J., van Kasteren, M.E.E., Berrevoets, M.A.H., Brouwer, A.E., de Kruijf-van de Wiel, B.A.F.M., Adams, A., Pawels-van Rijkevoorsel, M., Murck, J.L., Rokx, C., Anas, A.A., Bax, H.I., van Gorp, E.C.M., de Mendonça Melo, M., van Nood, E., Nouwen, J.L., Rijnders, B.J.A., Schurink, C.A.M., Slobbe, L., de Vries-Sluijs, T.E.M.S., Bassant, N., van Beek, J.E.A., Vriesde, M., van Zonneveld, L.M., de Groot, J., van Kampen, J.J.A., Koopmans, M.P.G., Rahamat-Langendoen, J.C., Branger, J., Douma, R.A., Cents-Bosma, A.S., Mulder, M.A., Schippers, E.F., van Nieuwkoop, C., Geilings, J., van de Ven, E., van der Hut, G., van Burgel, N.D., Leyten, E.M.S., Gelinck, L.B.S., Mollema, F., Langbein, M., Wildenbeest, G.S., Nguyen, T., Groeneveld, P.H.P., Bouwhuis, J.W., Lammers, A.J.J., van Hulzen, A.G.W., Kraan, S., Kruiper, M.S.M., Debast, S.B., Wagenvoort, G.H.J., Roukens, A.H.E., de Boer, M.G.J., Jolink, H., Lambregts, M.M.C., Scheper, H., van Holten, N., van der Sluis, D., Claas, E.C.J., Wessels, E., den Hollander, J.G., El Moussaoui, R., Pogany, K., Brouwer, C.J., Heida-Peters, D., Mulder, E., Smit, J.V., Struik-Kalkman, D., van Niekerk, T., Pontesilli, O., van Tienen, C., Lowe, S.H., Oude Lashof, A.M.L., Posthouwer, D., Stoop, A., van Wolfswinkel, M.E., Ackens, R.P., Elasri, M., Houben-Pintaric, K., Schippers, J., Havenith, T.R.A., van Loo, M., van Vonderen, M.G.A., Kampschreur, L.M., Timmer, C., van Broekhuizen, M.C., Faber, S., Al Moujahid, A., Kootstra, G.J., Delsing, C.E., van der Burg-van de Plas, M., Scheiberlich, L., Kortmann, W., van Twillert, G., Renckens, R., Wagenaar, J., Ruiter-Pronk, D., Stander, B., Cohen Stuart, J.W.T., Hoogewerf, M., Rozemeijer, W., Sinnige, J.C., Brinkman, K., van den Berk, G.E.L., Lettinga, K.D., de Regt, M., Schouten, W.E.M., Stalenhoef, J.E., Blaauw, H., Geerders, G.F., Kleene, M.J., Knapen, M., Kok, M., van der Meché, I.B., Toonen, A.J.M., Wijnands, S., Wttewaal, E., Kwa, D., van de Laar, T.J.W., van Crevel, R., van Aerde, K., Dofferhoff, A.S.M., Henriet, S.S.V., ter Hofstede, H.J.M., Hoogerwerf, J., Richel, O., Albers, M., Grintjes-Huisman, K.J.T., de Haan, M., Marneef, M., McCall, M., Rahamat-Langendoen, J., Ruizendaal, E., Burger, D., Gisolf, E.H., Claassen, M., Hassing, R.J., ter Beest, G., van Bentum, P.H.M., Neijland, Y., Valette, M., Swanink, C.M.A., Klein Velderman, M., van Lelyveld, S.F.L., Soetekouw, R., van der Prijt, L.M.M., van der Swaluw, J., Kalpoe, J.S., Wagemakers, A., Vahidnia, A., Lauw, F.N., Verhagen, D.W.M., van Wijk, M., Bierman, W.F.W., Bakker, M., van Bentum, R.A., van den Boomgaard, M.A., Kleinnijenhuis, J., Kloeze, E., Middel, A., Postma, D.F., Schenk, H.M., Stienstra, Y., Wouthuyzen-Bakker, M., Boonstra, A., Maerman, M.M.M., de Weerd, D.A., van Eije, K.J., Knoester, M., van Leer-Buter, C.C., Niesters, H.G.M., Barth, R.E., Bruns, A.H.W., Ellerbroek, P.M., Hensgens, M.P.M., Oosterheert, J.J., Schadd, E.M., Verbon, A., Griffioen-van Santen, B.M.G., de Kroon, I., Schuurman, R., Verduyn Lunel, F.M., Wensing, A.M.J., van der Valk, M., Zaheri, S., Boyd, A.C., Bezemer, D.O., Jongen, V.W., van Sighem, A.I., Smit, C., Wit, F.W.M.N., Hillebregt, M.M.J., Woudstra, T.J., Rutkens, T., Bergsma, D., Brétin, N.M., Koster, L.E., Lelivelt, K.J., van de Sande, L., Schoorl, M.J.C., Visser, K.M., van der Vliet, S.T., Paling, F., van den Akker, M., Akpomukai, O.M., Alexander, R., Bakker, Y.M., Bastos Sales, L., El Berkaoui, A., Bezemer-Goedhart, M., Djoechro, E.A., Grolleman, J.M., El Hammoud, I., Khouw, M.R., Lodewijk, C.R.E., Lucas, E.G.A., van Meerveld-Derks, S., Mulder, H.W., Munjishvili, L., Ree, C.M.J., Regtop, R., van Rijk, A.F., Ruijs-Tiggelman, Y.M.C., Schnörr, P.P., van Veen, R., van Vliet-Klein Gunnewiek, W.H.G., and Witte, E.C.M.
- Abstract
Currently, real-world data on doravirine are scarce. In a national prospective cohort, we assessed the effectiveness and tolerability of switching to doravirine-based antiretroviral therapy (ART) in people with HIV.
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- 2024
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10. Safe Stop IPI-NIVO trial: early discontinuation of nivolumab upon achieving a complete or partial response in patients with irresectable stage III or metastatic melanoma treated with first-line ipilimumab-nivolumab – study protocol
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Cancer, MS Medische Oncologie, Janssen, J. C., van Dijk, B., de Joode, K., Aarts, M. J.B., van den Berkmortel, F. W.P.J., Blank, C. U., Boers-Sonderen, M. J., van den Eertwegh, A. J.M., de Groot, J. W.B., Jalving, M., de Jonge, M. J.A., Joosse, A., Kapiteijn, E., Kamphuis-Huismans, A. M., Naipal, K. A.T., Piersma, D., Rikhof, B., Westgeest, H. M., Vreugdenhil, G., Oomen-de Hoop, E., Mulder, E. E.A.P., van der Veldt, Astrid A.M., Cancer, MS Medische Oncologie, Janssen, J. C., van Dijk, B., de Joode, K., Aarts, M. J.B., van den Berkmortel, F. W.P.J., Blank, C. U., Boers-Sonderen, M. J., van den Eertwegh, A. J.M., de Groot, J. W.B., Jalving, M., de Jonge, M. J.A., Joosse, A., Kapiteijn, E., Kamphuis-Huismans, A. M., Naipal, K. A.T., Piersma, D., Rikhof, B., Westgeest, H. M., Vreugdenhil, G., Oomen-de Hoop, E., Mulder, E. E.A.P., and van der Veldt, Astrid A.M.
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- 2024
11. Safe Stop IPI-NIVO trial:early discontinuation of nivolumab upon achieving a complete or partial response in patients with irresectable stage III or metastatic melanoma treated with first-line ipilimumab-nivolumab – study protocol
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Janssen, J. C., van Dijk, B., de Joode, K., Aarts, M. J.B., van den Berkmortel, F. W.P.J., Blank, C. U., Boers-Sonderen, M. J., van den Eertwegh, A. J.M., de Groot, J. W.B., Jalving, M., de Jonge, M. J.A., Joosse, A., Kapiteijn, E., Kamphuis-Huismans, A. M., Naipal, K. A.T., Piersma, D., Rikhof, B., Westgeest, H. M., Vreugdenhil, G., Oomen-de Hoop, E., Mulder, E. E.A.P., van der Veldt, Astrid A.M., Janssen, J. C., van Dijk, B., de Joode, K., Aarts, M. J.B., van den Berkmortel, F. W.P.J., Blank, C. U., Boers-Sonderen, M. J., van den Eertwegh, A. J.M., de Groot, J. W.B., Jalving, M., de Jonge, M. J.A., Joosse, A., Kapiteijn, E., Kamphuis-Huismans, A. M., Naipal, K. A.T., Piersma, D., Rikhof, B., Westgeest, H. M., Vreugdenhil, G., Oomen-de Hoop, E., Mulder, E. E.A.P., and van der Veldt, Astrid A.M.
- Abstract
Background: Patients with irresectable stage III or metastatic melanoma presenting with poor prognostic factors are usually treated with a combination of immune checkpoint inhibitors (ICIs), consisting of ipilimumab and nivolumab. This combination therapy is associated with severe immune related adverse events (irAEs) in about 60% of patients. In current clinical practice, patients are usually treated with ICIs for up to two years or until disease progression or the occurrence of unacceptable AEs. The incidence of irAEs gradually increases with duration of treatment. While durable tumour responses have been observed after early discontinuation of treatment, no consensus has been reached on optimal treatment duration. The objective of the Safe Stop IPI-NIVO trial is to evaluate whether early discontinuation of ICIs is safe in patients with irresectable stage III or metastatic melanoma who are treated with combination therapy. Methods: The Safe Stop IPI-NIVO trial is a nationwide, multicentre, prospective, single-arm, interventional study in the Netherlands. A total of 80 patients with irresectable stage III or metastatic melanoma who are treated with combination therapy of ipilimumab-nivolumab and have a complete or partial response (CR/PR) according to RECIST v1.1 will be included to early discontinue maintenance therapy with anti-PD-1. The primary endpoint is the rate of ongoing response at 12 months after start of ICI. Secondary endpoints include ongoing response at 24 months, disease control at different time points, melanoma specific and overall survival, the incidence of irAEs and health-related quality of life. Discussion: From a medical, healthcare and economic perspective, overtreatment should be prevented and shorter treatment duration of ICIs is preferred. If early discontinuation of ICIs is safe for patients who are treated with the combination of ipilimumab-nivolumab, the treatment duration of nivolumab could be shortened in patients with a favourable
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- 2024
12. Effects of 30 days bed rest and exercise countermeasures on PBMC bioenergetics
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Buescher, F.‐M., primary, Schmitz, M. T., additional, Frett, T., additional, Kramme, J., additional, de Boni, L., additional, Elmenhorst, E. M., additional, Mulder, E., additional, Moestl, S., additional, Heusser, K., additional, Frings‐Meuthen, P., additional, Jordan, J., additional, Rittweger, J., additional, and Pesta, D., additional
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- 2024
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13. Early discontinuation of PD-1 blockade upon achieving a complete or partial response in patients with advanced melanoma: the multicentre prospective Safe Stop trial
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Mulder, E. E. A. P., de Joode, K., Litière, S., ten Tije, A. J., Suijkerbuijk, K. P. M., Boers-Sonderen, M. J., Hospers, G. A. P., de Groot, J. W. B., van den Eertwegh, A. J. M., Aarts, M. J. B., Piersma, D., van Rijn, R. S., Kapiteijn, E., Vreugdenhil, G., van den Berkmortel, F. W. P. J., Hoop, E. Oomen-de, Franken, M. G., Ryll, B., Rutkowski, P., Sleijfer, S., Haanen, J. B. A. G., and van der Veldt, A. A. M.
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- 2021
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14. Von humanen terrestrischen Modellen zu neuen Präventionsansätzen für Augenveränderungen bei Astronauten: Ergebnisse der Studien des Deutschen Zentrums für Luft- und Raumfahrt
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Jordan, J., Hellweg, C. E., Mulder, E., and Stern, C.
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- 2020
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15. LOFAR: The LOw-Frequency ARray
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van Haarlem, M. P., Wise, M. W., Gunst, A. W., Heald, G., McKean, J. P., Hessels, J. W. T., de Bruyn, A. G., Nijboer, R., Swinbank, J., Fallows, R., Brentjens, M., Nelles, A., Beck, R., Falcke, H., Fender, R., Hörandel, J., Koopmans, L. V. E., Mann, G., Miley, G., Röttgering, H., Stappers, B. W., Wijers, R. A. M. J., Zaroubi, S., Akker, M. van den, Alexov, A., Anderson, J., Anderson, K., van Ardenne, A., Arts, M., Asgekar, A., Avruch, I. M., Batejat, F., Bähren, L., Bell, M. E., Bell, M. R., van Bemmel, I., Bennema, P., Bentum, M. J., Bernardi, G., Best, P., Bîrzan, L., Bonafede, A., Boonstra, A. -J., Braun, R., Bregman, J., Breitling, F., van de Brink, R. H., Broderick, J., Broekema, P. C., Brouw, W. N., Brüggen, M., Butcher, H. R., van Cappellen, W., Ciardi, B., Coenen, T., Conway, J., Coolen, A., Corstanje, A., Damstra, S., Davies, O., Deller, A. T., Dettmar, R. -J., van Diepen, G., Dijkstra, K., Donker, P., Doorduin, A., Dromer, J., Drost, M., van Duin, A., Eislöffel, J., van Enst, J., Ferrari, C., Frieswijk, W., Gankema, H., Garrett, M. A., de Gasperin, F., Gerbers, M., de Geus, E., Grießmeier, J. -M., Grit, T., Gruppen, P., Hamaker, J. P., Hassall, T., Hoeft, M., Holties, H., Horneffer, A., van der Horst, A., van Houwelingen, A., Huijgen, A., Iacobelli, M., Intema, H., Jackson, N., Jelic, V., de Jong, A., Juette, E., Kant, D., Karastergiou, A., Koers, A., Kollen, H., Kondratiev, V. I., Kooistra, E., Koopman, Y., Koster, A., Kuniyoshi, M., Kramer, M., Kuper, G., Lambropoulos, P., Law, C., van Leeuwen, J., Lemaitre, J., Loose, M., Maat, P., Macario, G., Markoff, S., Masters, J., McKay-Bukowski, D., Meijering, H., Meulman, H., Mevius, M., Middelberg, E., Millenaar, R., Miller-Jones, J. C. A., Mohan, R. N., Mol, J. D., Morawietz, J., Morganti, R., Mulcahy, D. D., Mulder, E., Munk, H., Nieuwenhuis, L., van Nieuwpoort, R., Noordam, J. E., Norden, M., Noutsos, A., Offringa, A. R., Olofsson, H., Omar, A., Orrú, E., Overeem, R., Paas, H., Pandey-Pommier, M., Pandey, V. N., Pizzo, R., Polatidis, A., Rafferty, D., Rawlings, S., Reich, W., de Reijer, J. -P., Reitsma, J., Renting, A., Riemers, P., Rol, E., Romein, J. W., Roosjen, J., Ruiter, M., Scaife, A., van der Schaaf, K., Scheers, B., Schellart, P., Schoenmakers, A., Schoonderbeek, G., Serylak, M., Shulevski, A., Sluman, J., Smirnov, O., Sobey, C., Spreeuw, H., Steinmetz, M., Sterks, C. G. M., Stiepel, H. -J., Stuurwold, K., Tagger, M., Tang, Y., Tasse, C., Thomas, I., Thoudam, S., Toribio, M. C., van der Tol, B., Usov, O., van Veelen, M., van der Veen, A. -J., ter Veen, S., Verbiest, J. P. W., Vermeulen, R., Vermaas, N., Vocks, C., Vogt, C., de Vos, M., van der Wal, E., van Weeren, R., Weggemans, H., Weltevrede, P., White, S., Wijnholds, S. J., Wilhelmsson, T., Wucknitz, O., Yatawatta, S., Zarka, P., Zensus, A., and van Zwieten, J.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
LOFAR, the LOw-Frequency ARray, is a new-generation radio interferometer constructed in the north of the Netherlands and across europe. Utilizing a novel phased-array design, LOFAR covers the largely unexplored low-frequency range from 10-240 MHz and provides a number of unique observing capabilities. Spreading out from a core located near the village of Exloo in the northeast of the Netherlands, a total of 40 LOFAR stations are nearing completion. A further five stations have been deployed throughout Germany, and one station has been built in each of France, Sweden, and the UK. Digital beam-forming techniques make the LOFAR system agile and allow for rapid repointing of the telescope as well as the potential for multiple simultaneous observations. With its dense core array and long interferometric baselines, LOFAR achieves unparalleled sensitivity and angular resolution in the low-frequency radio regime. The LOFAR facilities are jointly operated by the International LOFAR Telescope (ILT) foundation, as an observatory open to the global astronomical community. LOFAR is one of the first radio observatories to feature automated processing pipelines to deliver fully calibrated science products to its user community. LOFAR's new capabilities, techniques and modus operandi make it an important pathfinder for the Square Kilometre Array (SKA). We give an overview of the LOFAR instrument, its major hardware and software components, and the core science objectives that have driven its design. In addition, we present a selection of new results from the commissioning phase of this new radio observatory., Comment: 56 pages, 34 figures, accepted for publication by A&A
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- 2013
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16. Optimized Trigger for Ultra-High-Energy Cosmic-Ray and Neutrino Observations with the Low Frequency Radio Array
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Singh, K., Mevius, M., Scholten, O., Anderson, J. M., van Ardenne, A., Arts, M., Avruch, M., Asgekar, A., Bell, M., Bennema, P., Bentum, M., Bernadi, G., Best, P., Boonstra, A. -J., Bregman, J., van de Brink, R., Broekema, C., Brouw, W., Brueggen, M., Buitink, S., Butcher, H., van Cappellen, W., Ciardi, B., Coolen, A., Damstra, S., Dettmar, R., van Diepen, G., Dijkstra, K., Donker, P., Doorduin, A., Drost, M., van Duin, A., Eisloeffel, J., Falcke, H., Garrett, M., Gerbers, M., Griessmeier, J., Grit, T., Gruppen, P., Gunst, A., van Haarlem, M., Hoeft, M., Holties, H., Horandel, J., Horneffer, L. A., Huijgen, A., James, C., de Jong, A., Kant, D., Kooistra, E., Koopman, Y., Koopmans, L., Kuper, G., Lambropoulos, P., van Leeuwen, J., Loose, M., Maat, P., Mallary, C., McFadden, R., Meulman, H., Mol, J. -D., Morawietz, J., Mulder, E., Munk, H., Nieuwenhuis, L., Nijboer, R., Norden, M., Noordam, J., Overeem, R., Paas, H., Pandey, V. N., Pandey-Pommier, M., Pizzo, R., Polatidis, A., Reich, W., de Reijer, J., Renting, A., Riemers, P., Roettgering, H., Romein, J., Roosjen, J., Ruiter, M., Schoenmakers, A., Schoonderbeek, G., Sluman, J., Smirnov, O., Stappers, B., Steinmetz, M., Stiepel, H., Stuurwold, K., Tagger, M., Tang, Y., ter Veen, S., Vermeulen, R., de Vos, M., Vogt, C., van der Wal, E., Weggemans, H., Wijnholds, S., Wise, M., Wucknitz, O., Yattawatta, S., and van Zwieten, J.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
When an ultra-high energy neutrino or cosmic ray strikes the Lunar surface a radio-frequency pulse is emitted. We plan to use the LOFAR radio telescope to detect these pulses. In this work we propose an efficient trigger implementation for LOFAR optimized for the observation of short radio pulses., Comment: Submitted to Nuclear Instruments and Methods in Physics Research Section A
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- 2011
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17. Impact of daily artificial gravity on autonomic cardiovascular control following 60-day head-down tilt bed rest
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Hoenemann, J.-N., primary, Moestl, S., additional, Diedrich, A., additional, Mulder, E., additional, Frett, T., additional, Petrat, G., additional, Pustowalow, W., additional, Arz, M., additional, Schmitz, M.-T., additional, Heusser, K., additional, Lee, S. M. C., additional, Jordan, J., additional, Tank, J., additional, and Hoffmann, F., additional
- Published
- 2023
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18. Prediction model for hypertension in first decade after pre‐eclampsia in initially normotensive women
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Hooijschuur, M. C. E., primary, Janssen, E. B. N. J., additional, Mulder, E. G., additional, Kroon, A. A., additional, Meijers, J. M. J., additional, Brugts, J. J., additional, van Bussel, B. C. T., additional, van Kuijk, S. M. J., additional, Spaanderman, M. E. A., additional, and Ghossein‐Doha, C., additional
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- 2023
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19. Dioctowittus hughjonesi sp. n. (Nematoda: Cystoopsidae) from Liasis fuscus (Peters, 1873) (Serpentes: Boidae) from the Northern Territory and Morelia amethistina (Schneider, 1802) from Queensland, Australia
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Mulder, E, Smales, L R, and BioStor
- Published
- 2006
20. CTG-patronen en het foetale gedrag
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Nijhuis, J. G., Mulder, E. J. H., Nijhuis, J.G., editor, Essed, G.G.M., editor, van Geijn, H.P., editor, and Visser, G.H.A., editor
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- 2016
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21. An integrated approach to meet the needs of high-vulnerable families: a qualitative study on integrated care from a professional perspective
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Nooteboom, L. A., van den Driesschen, S. I., Kuiper, C. H. Z., Vermeiren, R. R. J. M., and Mulder, E. A.
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- 2020
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22. Looking into the crystal ball: quality of life, delinquency, and problems experienced by young male adults after discharge from a secure residential care setting in the Netherlands
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Janssen-de Ruijter, E. A. W., Mulder, E. A., Bongers, I. L., Omlo, L., and van Nieuwenhuizen, Ch.
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- 2019
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23. Geo-environmental Aspects of European Underground Infrastructure
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de Mulder, E. F. J., van Ree, C. C. D. F., Hack, H. R. G. K., Culshaw, M.G., editor, Osipov, V.I., editor, Booth, S.J., editor, and Victorov, A.S., editor
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- 2015
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24. SoC It to EM: ElectroMagnetic Side-Channel Attacks on a Complex System-on-Chip
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Longo, J., De Mulder, E., Page, D., Tunstall, M., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Güneysu, Tim, editor, and Handschuh, Helena, editor
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- 2015
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25. Small-scale, Community-Embedded Youth Justice Facilities: Lessons from Dutch Reforms and Recommendations for Cross-Jurisdictional Implementation
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Souverein, F, Oostermeijer, S, Johns, D, Ross, S, van Domburgh, L, Popma, A, Mulder, E, Souverein, F, Oostermeijer, S, Johns, D, Ross, S, van Domburgh, L, Popma, A, and Mulder, E
- Abstract
Youth justice settings should provide safe, therapeutic environments, tailored to young people's needs. Current custodial models rarely meet these aims, mainly because a focus on security tends to outweigh an emphasis on care, diminishing rather than encouraging young people's positive development. This article reports on a three-year evaluation of youth justice reforms in the Netherlands, including small-scale, community-embedded facilities with an emphasis on relational security. We outline key operational elements and conditions for implementation of these facilities to provide guidance for youth justice professionals, and for managers and policymakers seeking to promote political and financial investments in effective youth justice strategies.
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- 2023
26. Nuclear segmentation facilitates neutrophil migration.
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Shen, C., Mulder, E. de, Buitenwerf, W., Postat, J., Jansen, A., Kox, M., Mandl, J.N., Vrisekoop, N., Shen, C., Mulder, E. de, Buitenwerf, W., Postat, J., Jansen, A., Kox, M., Mandl, J.N., and Vrisekoop, N.
- Abstract
Item does not contain fulltext, Neutrophils are among the fastest-moving immune cells. Their speed is critical to their function as 'first responder' cells at sites of damage or infection, and it has been postulated that the unique segmented nucleus of neutrophils functions to assist their rapid migration. Here, we tested this hypothesis by imaging primary human neutrophils traversing narrow channels in custom-designed microfluidic devices. Individuals were given an intravenous low dose of endotoxin to elicit recruitment of neutrophils into the blood with a high diversity of nuclear phenotypes, ranging from hypo- to hyper-segmented. Both by cell sorting of neutrophils from the blood using markers that correlate with lobularity and by directly quantifying the migration of neutrophils with distinct lobe numbers, we found that neutrophils with one or two nuclear lobes were significantly slower to traverse narrower channels, compared to neutrophils with more than two nuclear lobes. Thus, our data show that nuclear segmentation in primary human neutrophils provides a speed advantage during migration through confined spaces.
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- 2023
27. Effects of daily artificial gravity training on orthostatic tolerance following 60-day strict head-down tilt bedrest.
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Hoenemann, J.N., Moestl, S., Herwaarden, A.E. van, Diedrich, A., Mulder, E., Frett, T., Petrat, G., Pustowalow, W., Arz, M., Heusser, K., Lee, S., Jordan, J., Tank, J., Hoffmann, F., Hoenemann, J.N., Moestl, S., Herwaarden, A.E. van, Diedrich, A., Mulder, E., Frett, T., Petrat, G., Pustowalow, W., Arz, M., Heusser, K., Lee, S., Jordan, J., Tank, J., and Hoffmann, F.
- Abstract
01 augustus 2023, Contains fulltext : 295998.pdf (Publisher’s version ) (Open Access), PURPOSE: Orthostatic intolerance commonly occurs following immobilization or space flight. We hypothesized that daily artificial gravity training through short-arm centrifugation could help to maintain orthostatic tolerance following head-down tilt bedrest, which is an established terrestrial model for weightlessness. METHODS: We studied 24 healthy persons (eight women; age 33.3 ± 9.0 years; BMI 24.3 ± 2.1 kg/m(2)) who participated in the 60-days head-down tilt bedrest (AGBRESA) study. They were assigned to 30 min/day continuous or 6 × 5 min intermittent short-arm centrifugation with 1Gz at the center of mass or a control group. We performed head-up tilt testing with incremental lower-body negative pressure until presyncope before and after bedrest. We recorded an electrocardiogram, beat-to-beat finger blood pressure, and brachial blood pressure and obtained blood samples from an antecubital venous catheter. Orthostatic tolerance was defined as time to presyncope. We related changes in orthostatic tolerance to changes in plasma volume determined by carbon dioxide rebreathing. RESULTS: Compared with baseline measurements, supine and upright heart rate increased in all three groups following head-down tilt bedrest. Compared with baseline measurements, time to presyncope decreased by 323 ± 235 s with continuous centrifugation, by 296 ± 508 s with intermittent centrifugation, and by 801 ± 354 s in the control group (p = 0.0249 between interventions). The change in orthostatic tolerance was not correlated with changes in plasma volume. CONCLUSIONS: Daily artificial gravity training on a short-arm centrifuge attenuated the reduction in orthostatic tolerance after 60 days of head-down tilt bedrest.
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- 2023
28. Prediction model for hypertension in first decade after pre-eclampsia in initially normotensive women
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Hooijschuur, M. C.E., Janssen, E. B.N.J., Mulder, E. G., Kroon, A. A., Meijers, J. M.J., Brugts, J. J., Van Bussel, B. C.T., Van Kuijk, S. M.J., Spaanderman, M. E.A., Ghossein-Doha, C., Hooijschuur, M. C.E., Janssen, E. B.N.J., Mulder, E. G., Kroon, A. A., Meijers, J. M.J., Brugts, J. J., Van Bussel, B. C.T., Van Kuijk, S. M.J., Spaanderman, M. E.A., and Ghossein-Doha, C.
- Abstract
Objective: To develop a prediction model for the development of hypertension in the decade following pre-eclampsia in women who were normotensive shortly after pregnancy. Methods: This was a longitudinal cohort study of formerly pre-eclamptic women attending a university hospital in The Netherlands between 1996 and 2019. We developed a prediction model for incident hypertension using multivariable logistic regression analysis. The model was validated internally using bootstrapping techniques. Results: Of 259 women, 185 (71%) were normotensive at the first cardiovascular assessment, at a median of 10 (interquartile range (IQR), 6–24) months after a pre-eclamptic pregnancy, of whom 49 (26%) had developed hypertension by the second visit, at a median of 11 (IQR, 6–14) years postpartum. The prediction model, based on birth-weight centile, mean arterial pressure, total cholesterol, left ventricular mass index and left ventricular ejection fraction, had good-to-excellent discriminative ability, with an area under the receiver-operating-characteristics curve (AUC) of 0.82 (95% CI, 0.75–0.89) and an optimism-corrected AUC of 0.80. The sensitivity and specificity of our model to predict hypertension were 98% and 34%, respectively, and positive and negative predictive values were 35% and 98%, respectively. Conclusions: Based on five variables, we developed a good-to-excellent predictive tool to identify incident hypertension following pre-eclampsia in women who were normotensive shortly after pregnancy. After external validation, this model could have considerable clinical utility in tackling the cardiovascular legacy of pre-eclampsia.
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- 2023
29. External validation of the PAGE-B score for HCC risk prediction in people living with HIV/HBV coinfection
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Egger, M., Hoffmann, M., Rauch, A., van der Valk, M., Goorhuis, A., Prins, J. M., van Vugt, M., Wit, F. W.M.N., Cornelissen, M. T.E., Jonges, M., Wolthers, K. C., Zaaijer, H. L., Peters, E. J.G., van Agtmael, M. A., Autar, R. S., Laan, L. M., van den Berge, M., Baas, S., van Arkel, A., Pronk, M. J.H., Alers, W., Nobel, H., Berrevoets, M. A.H., Brouwer, A. E., Rokx, C., Anas, A. A., Bax, H. I., van Gorp, E. C.M., van Nood, E., Nouwen, J. L., Rijnders, B. J.A., Schurink, C. A.M., Slobbe, L., de Vries-Sluijs, T. E.M.S., Bassant, N., van Beek, J. E.A., Vriesde, M., van Zonneveld, L. M., de Groot, J., van Kampen, J. J.A., Koopmans, M. P.G., Rahamat-Langendoen, J. C., Douma, R. A., Schippers, E. F., Gelinck, L. B.S., Mollema, F., Nguyen, T., Groeneveld, P. H.P., Lammers, A. J.J., de Boer, M. G.J., Claas, E. C.J., Brouwer, C. J., Mulder, E., Smit, J. V., van Niekerk, T., Pontesilli, O., van Tienen, C., van Wolfswinkel, M. E., Schippers, J., Kampschreur, L. M., Wagenaar, J., de Regt, M., Schouten, W. E.M., Veenstra, J., Blaauw, H., Knapen, M., Kok, M., Albers, M., de Haan, M., McCall, M., Burger, D., Claassen, M., Hassing, R. J., Verhagen, D. W.M., van Wijk, M., Bakker, M., Postma, D. F., Schenk, H. M., Boonstra, A., de Jonge, H., Niesters, H. G.M., Bruns, A. H.W., Hensgens, M. P.M., Oosterheert, J. J., Verbon, A., Berends, H., Bezemer, D. O., Smit, C., Bergsma, D., Lelivelt, K. J., van de Sande, L., van den Akker, M., Bakker, Y., Bezemer-Goedhart, M., Koster, L. E., Lucas, E. G.A., Schoorl, M. J.C., Witte, E. C.M., Peters, L., Larsen, J. F., Fischer, A. H., Jensen, S. K., Nguyen, D., Garcia, M., Egger, M., Hoffmann, M., Rauch, A., van der Valk, M., Goorhuis, A., Prins, J. M., van Vugt, M., Wit, F. W.M.N., Cornelissen, M. T.E., Jonges, M., Wolthers, K. C., Zaaijer, H. L., Peters, E. J.G., van Agtmael, M. A., Autar, R. S., Laan, L. M., van den Berge, M., Baas, S., van Arkel, A., Pronk, M. J.H., Alers, W., Nobel, H., Berrevoets, M. A.H., Brouwer, A. E., Rokx, C., Anas, A. A., Bax, H. I., van Gorp, E. C.M., van Nood, E., Nouwen, J. L., Rijnders, B. J.A., Schurink, C. A.M., Slobbe, L., de Vries-Sluijs, T. E.M.S., Bassant, N., van Beek, J. E.A., Vriesde, M., van Zonneveld, L. M., de Groot, J., van Kampen, J. J.A., Koopmans, M. P.G., Rahamat-Langendoen, J. C., Douma, R. A., Schippers, E. F., Gelinck, L. B.S., Mollema, F., Nguyen, T., Groeneveld, P. H.P., Lammers, A. J.J., de Boer, M. G.J., Claas, E. C.J., Brouwer, C. J., Mulder, E., Smit, J. V., van Niekerk, T., Pontesilli, O., van Tienen, C., van Wolfswinkel, M. E., Schippers, J., Kampschreur, L. M., Wagenaar, J., de Regt, M., Schouten, W. E.M., Veenstra, J., Blaauw, H., Knapen, M., Kok, M., Albers, M., de Haan, M., McCall, M., Burger, D., Claassen, M., Hassing, R. J., Verhagen, D. W.M., van Wijk, M., Bakker, M., Postma, D. F., Schenk, H. M., Boonstra, A., de Jonge, H., Niesters, H. G.M., Bruns, A. H.W., Hensgens, M. P.M., Oosterheert, J. J., Verbon, A., Berends, H., Bezemer, D. O., Smit, C., Bergsma, D., Lelivelt, K. J., van de Sande, L., van den Akker, M., Bakker, Y., Bezemer-Goedhart, M., Koster, L. E., Lucas, E. G.A., Schoorl, M. J.C., Witte, E. C.M., Peters, L., Larsen, J. F., Fischer, A. H., Jensen, S. K., Nguyen, D., and Garcia, M.
- Abstract
Background & Aims: HBV coinfection is common among people living with HIV (PLWH) and is the most important cause of hepatocellular carcinoma (HCC). While risk prediction tools for HCC have been validated in patients with HBV monoinfection, they have not been evaluated in PLWH. Thus, we performed an external validation of PAGE-B in people with HIV/HBV coinfection. Methods: We included data on PLWH from four European cohorts who were positive for HBsAg and did not have HCC before starting tenofovir. We estimated the predictive performance of PAGE-B for HCC occurrence over 15 years in patients receiving tenofovir-containing antiretroviral therapy. Model discrimination was assessed after multiple imputation using Cox regression with the prognostic index as a covariate, and by calculating Harrell's c-index. Calibration was assessed by comparing our cumulative incidence with the PAGE-B derivation study using Kaplan-Meier curves. Results: In total, 2,963 individuals with HIV/HBV coinfection on tenofovir-containing antiretroviral therapy were included. PAGE-B was <10 in 26.5%, 10–17 in 57.7%, and ≥18 in 15.7% of patients. Within a median follow-up of 9.6 years, HCC occurred in 68 individuals (2.58/1,000 patient-years, 95% CI 2.03–3.27). The regression slope of the prognostic index for developing HCC within 15 years was 0.93 (95% CI 0.61–1.25), and the pooled c-index was 0.77 (range 0.73–0.80), both indicating good model discrimination. The cumulative incidence of HCC was lower in our study compared to the derivation study. A PAGE-B cut-off of <10 had a negative predictive value of 99.4% for the development of HCC within 5 years. Restricting efforts to individuals with a PAGE-B of ≥10 would spare unnecessary HCC screening in 27% of individuals. Conclusions: For individuals with HIV/HBV coinfection, PAGE-B is a valid tool to determine the need for HCC screening. Impact and impl
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- 2023
30. Human gut microbiome and metabolite dynamics under simulated microgravity
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Ramos-Nascimento, A., Grenga, L., Haange, Sven Bastiaan, Himmelmann, A., Arndt, F.S., Ly, Y.-T., Miotello, G., Pible, O., Jehmlich, Nico, Engelmann, Beatrice, von Bergen, Martin, Mulder, E., Frings-Meuthen, P., Hellweg, C.E., Jordan, J., Rolle-Kampczyk, Ulrike, Armengaud, J., Moeller, R., Ramos-Nascimento, A., Grenga, L., Haange, Sven Bastiaan, Himmelmann, A., Arndt, F.S., Ly, Y.-T., Miotello, G., Pible, O., Jehmlich, Nico, Engelmann, Beatrice, von Bergen, Martin, Mulder, E., Frings-Meuthen, P., Hellweg, C.E., Jordan, J., Rolle-Kampczyk, Ulrike, Armengaud, J., and Moeller, R.
- Abstract
The Artificial Gravity Bed Rest – European Space Agency (AGBRESA) study was the first joint bed rest study by ESA, DLR, and NASA that examined the effect of simulated weightlessness on the human body and assessed the potential benefits of artificial gravity as a countermeasure in an analog of long-duration spaceflight. In this study, we investigated the impact of simulated microgravity on the gut microbiome of 12 participants during a 60-day head-down tilt bed rest at the :envihab facilities. Over 60 days of simulated microgravity resulted in a mild change in the gut microbiome, with distinct microbial patterns and pathway expression in the feces of the countermeasure group compared to the microgravity simulation-only group. Additionally, we found that the countermeasure protocols selectively increased the abundance of beneficial short-chain fatty acids in the gut, such as acetate, butyrate, and propionate. Some physiological signatures also included the modulation of taxa reported to be either beneficial or opportunistic, indicating a mild adaptation in the microbiome network balance. Our results suggest that monitoring the gut microbial catalog along with pathway clustering and metabolite profiling is an informative synergistic strategy to determine health disturbances and the outcome of countermeasure protocols for future space missions.
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- 2023
31. Longitudinal Changes in Cerebral Perfusion, Perivascular Space Volume, and Ventricular Volume in a Healthy Cohort Undergoing a Spaceflight Analog.
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Tidwell, J. B., Taylor, J. A., Collins, H. R., Chamberlin, J. H., Barisano, G., Sepehrband, F., Turner, M. D., Gauthier, G., Mulder, E. R., Gerlach, D. A., and Roberts, D. R.
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- 2023
- Full Text
- View/download PDF
32. A simple dried blood spot method for therapeutic drug monitoring of the tricyclic antidepressants amitriptyline, nortriptyline, imipramine, clomipramine, and their active metabolites using LC-MS/MS
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Berm, E.J.J., Paardekooper, J., Brummel-Mulder, E., Hak, E., Wilffert, B., and Maring, J.G.
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- 2015
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33. EFFECTS OF SIMULATED MICROGRAVITY ON THE GUT MICROBIOME OF THE PARTICIPANTS OF THE AGBRESA STUDY
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Ramos-Nascimento, A., Mulder, E., Frings-Meuthen, P., Hellweg, C.E., Jordan, J., Moeller, R., and and, the AGBRESA research team
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The Artificial Gravity Bed Rest – European Space Agency (AGBRESA) study ,Microgravity ,Microbiome - Published
- 2023
34. Oncological Safety and Potential Cost Savings of Routine vs Selective Histopathological Examination After Appendectomy Results of the Multicenter, Prospective, Cross-Sectional FANCY Study
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Bastiaenen, Vivian P., de Jonge, Joske, Corten, Bartholomeus J. G. A., de Savornin Lohman, Elise A. J., Kraima, Anne C., Swank, Hilko A., van Vliet, Jaap L. P., van Acker, Gijs J. D., van Geloven, Anna A. W., in'tHof, Klaas H., Koens, Lianne, de Reuver, Philip R., van Rossem, Charles C., Slooter, Gerrit D., Tanis, Pieter J., Terpstra, Valeska, Dijkgraaf, Marcel G. W., Bemelman, Willem A., Amelung, F. J., Atema, J. J., Bessems, S., Beunders, A. A. M., Bodewes, T. C. F., den Boer, F. C., Boerma, D., Boerma, E. G., van den Boezem, P., Bökkerink, W. J. V., van den Boogaart, D., Boogerd, L. S. F., Bouwman, H., Broos, A., Brueren, L. O., Bruinsma, W. E., Bruns, E. R. C., Castelijns, P. S. S., de Castro, S. M. M., Consten, E. C. J., Crolla, R. M. P. H., Dam, M. J., Dang, Q., Dekker, J. W. T., Deroose, J. P., Devriendt, S., Dijkema, E. J., Dijkstra, N., Driessen, M. L. S., van Duijvendijk, P., Duinhouwer, L. E., van Duyn, E. B., el-Massoudi, Y., Elfrink, A. K. E., Elschot, J. H., van Essen, J. A., Ferenschild, F. T. J., Gans, S. L., Gaznay, C., Geraedts, A. C. M., van Gessel, B. S. H., Giesen, L. J. X., van Gils, N., Gorgec, B., Gorter, R. R., Govaert, K. M., Greuter, G. N., van Grevenstein, W. M. U., Groot, L., Hardy, J. C. A., Heemskerk, J., Heeren, J. F., Heidotting, J., Heikens, J. T., Hosseinzoi, E., van Iersel, J. J., Inberg, B., Jansen, L. J., Jens, A. J. T., Jilesen, A. P. J., Joosten, M., de Jong, L., Keijzers, M., Klicks, R. J., Kloppenberg, F. W. H., Koedam, T. W. A., Koëter, T., Konsten, J. L. M., Koolen, L. J. E. R., Kruyt, Ph. M., Lange, J. F. M., Lavrijssen, B. D. A., de Leede, E. M., Leliefeld, P. H. C., Linnemann, R. J. A., Lo, G. C., van de Loo, M., Lubbert, P. H. W., Holzik, M. F. Lutke, Manusama, E., Masselink, I., Matthée, E. P. C., Matthijsen, R. A., Mearadji, A., Melenhorst, J., Merkus, J. W. S., Michiels, T. D., Moes, D. E., Moossdorff, M., Mulder, E., Nallayici, E. G., Neijenhuis, P. A., Nielsen, K., Nieuwenhuijzen, G. A. P., Nijhuis, J., Okkema, S., Olthof, P. B., van Onkelen, R. S., van Oostendorp, S. E., Plaisier, P. W., Polle, S. W., Reiber, B. M. M., Reichert, F. C. M., van Rest, K. L. C., van Rijn, R., Roozendaal, N. C., de Ruijter, W. M. J., Schat, E., Scheerhoorn, J., Scheijmans, J. C. G., Schimmer, J., Schipper, R. J., Schouten, R., Schreurs, W. H., Schrijver, W. A. M. E., Shapiro, J., Siemons, A., Silvis, R., Simkens, G. A., Smakman, N., Smeets, B. J. J., Sonneveld, D. J. A., van Suijlichem, M., Talsma, A. K., Thoolen, J. M. M., van Tol, R. R., Tournoij, E., Tseng, L. N. L., Tuynman, J. B., van der Velde, K., Veltkamp, S. C., Verbeek, F. P. R., Verdaasdonk, E., Verhaak, T., Verheuvel, N. C., Vermaas, M., Verseveld, M., Vlek, S., Vogels, S., van de Voort, E. M. F., van Vugt, S. T., Wegdam, J. A., Wennekers, M. M., Wiering, B., de Wijkerslooth, E. M. L., Wijkmans, A. A., Wijnhoven, B. P. L., Witjes, C. D. M., Wolfhagen, N., de Zeeuw, S., van Zoonen, G., Surgery, Erasmus MC other, Obstetrics & Gynecology, Department of Strategic Management and Entrepreneurship, Neurology, Rotterdam School of Management, Cardiology, Gastroenterology & Hepatology, Radiology & Nuclear Medicine, Otorhinolaryngology and Head and Neck Surgery, Emergency Medicine, Public Health, Plastic and Reconstructive Surgery and Hand Surgery, Dermatology, Clinical Chemistry, Internal Medicine, Erasmus School of Social and Behavioural Sciences, General Practice, Radiotherapy, Research & Education, Rehabilitation Medicine, Urology, Pathology, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Hematology laboratory, VU University medical center, CCA - Cancer Treatment and quality of life, and CCA - Imaging and biomarkers
- Subjects
medicine.medical_specialty ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,All institutes and research themes of the Radboud University Medical Center ,business.industry ,General surgery ,Medicine ,Surgery ,Histopathological examination ,business ,Cost savings - Abstract
Objective: To investigate the oncological safety and potential cost savings of selective histopathological examination after appendectomy. Background: The necessity of routine histopathological examination after appendectomy has been questioned, but prospective studies investigating the safety of a selective policy are lacking. Methods: In this multicenter, prospective, cross-sectional study, inspection and palpation of the (meso)appendix was performed by the surgeon in patients with suspected appendicitis. The surgeon's opinion on additional value of histopathological examination was reported before sending all specimens to the pathologist. Main outcomes were the number of hypothetically missed appendiceal neoplasms with clinical consequences benefiting the patient (upper limit two-sided 95% confidence interval below 3:1000 considered oncologically safe) and potential cost savings after selective histopathological examination. Results: Seven thousand three hundred thirty-nine patients were included. After a selective policy, 4966/7339 (67.7%) specimens would have been refrained from histopathological examination. Appendiceal neoplasms with clinical consequences would have been missed in 22/4966 patients. In 5/22, residual disease was completely resected during additional surgery. Hence, an appendiceal neoplasm with clinical consequences benefiting the patient would have been missed in 1.01:1000 patients (upper limit 95% confidence interval 1.61:1000). In contrast, twice as many patients (10/22) would not have been exposed to potential harm due to re-resections without clear benefit, whereas consequences were neither beneficial nor harmful in the remaining seven. Estimated cost savings established by replacing routine for selective histopathological examination were 725,400 per 10,000 patients. Conclusions: Selective histopathological examination after appendectomy for suspected appendicitis is oncologically safe and will likely result in a reduction of pathologists' workload, less costs, and fewer re-resections without clear benefit.
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- 2023
35. Improved SNAPPE-II and CRIB II scores over a 15-year period
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Groenendaal, F, de Vos, M C, Derks, J B, and Mulder, E J H
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- 2017
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36. Hyper.Campus – Effects of Artificial Gravity on Structural and Functional Brain Plasticity During Head-Down Tilt Bed Rest
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Stahn, A.-C., Basner, M., Brauns, K., Dinges, D., Garcia, C., Gerlach, D., Gunga, H., Gur, R., Hartley, T., Miller, N., Mulder, E., Mühl, C., Riecke, B., Roalf, D., Ruparel, K., Werner, A., and Kuehn, S.
- Subjects
spatial cognition ,bedrest ,artificial gravity ,cognitive performance - Published
- 2022
37. Prediction model for hypertension after preeclampsia in initially normotensive women; the Queen of Hearts cohort
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Hooijschuur, M, primary, Janssen, B N J, additional, Mulder, E G, additional, Kroon, A A, additional, Meijers, J M J, additional, Van Bussel, B C T, additional, Van Kuijk, S M J, additional, Spaanderman, M E A, additional, and Ghossein-Doha, C, additional
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- 2022
- Full Text
- View/download PDF
38. Functional connectivity of limbic system and prefrontal cortex years after pre‐eclampsia: 7‐Tesla functional magnetic resonance imaging study
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Canjels, L. P. W., primary, Ghossein‐Doha, C., additional, Alers, R. J., additional, Rutten, S., additional, van den Kerkhof, M., additional, Schiffer, V. M. M. M., additional, Mulder, E., additional, Gerretsen, S. C., additional, Aldenkamp, A. P., additional, Hurks, P. P. M., additional, van de Ven, V., additional, Spaanderman, M. E. A., additional, Jansen, J. F. A., additional, and Backes, W. H., additional
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- 2022
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39. Blood–brain barrier leakage years after pre‐eclampsia: dynamic contrast‐enhanced 7‐Tesla MRI study
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Canjels, L. P. W., primary, Jansen, J. F. A., additional, Alers, R. J., additional, Ghossein‐Doha, C., additional, van den Kerkhof, M., additional, Schiffer, V. M. M. M., additional, Mulder, E., additional, Gerretsen, S. C., additional, Aldenkamp, A. P., additional, Hurks, P. P. M., additional, van de Ven, V., additional, Spaanderman, M. E. A., additional, and Backes, W. H., additional
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- 2022
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40. Iron Metabolism Regulation in Females and Males Exposed to Simulated Microgravity: results from the Randomized Trial AGBRESA
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Horeau, M., Report, M., Mulder, E., Tank, J., Frings-Meuthen, P., Armbrecht, G., Loréal, O., Derbré, F., Jonchère, Laurent, Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire Mouvement Sport Santé (M2S), Université de Rennes (UR)-École normale supérieure - Rennes (ENS Rennes)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], German Aerospace Center (DLR), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], and The AGBRESA study was funded by DLR, ESA (contractnumber: 4000113871/15/NL/PG), and NASA (contract number: 80JSC018P0078). Theanalyses related to this study were supported by grants from the French 'Centre Nationald'Etudes Spatiales' (CNES) and the Brittany Council. The authors thank ElisabettaAndermarcher for expert manuscript editing
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spaceflight ,[SDV] Life Sciences [q-bio] ,[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition ,inflammation ,[SDV]Life Sciences [q-bio] ,metals ,trace elements ,disuse ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition - Abstract
International audience; BACKGROUND: Iron metabolism imbalance could contribute to physical deconditioning experienced by astronauts due to its essential role in energy metabolism, cellular respiration, and oxygen transport. OBJECTIVES: In this clinical exploratory study, we wanted to determine whether artificial gravity (AG) training modulated iron metabolism, red blood cell indices, and body lean mass in male and female healthy participants exposed to head-down tilt (HDT) bed rest, the reference ground-based model of microgravity. METHODS: We recruited 8 female and 16 male healthy participants who were all exposed to HDT bed rest for 60 days. In addition, they were assigned to three experimental groups (n = 8/each): controls, continuous AG training in a short-arm centrifuge (1×30 min/day), and intermittent AG training (6 × 5 min/day). RESULTS: The iron metabolism responses to simulated microgravity of AG training groups do not significantly differ from the responses of controls. Independently from AG, we found that both serum iron (+31.3%, P = 0.027) and transferrin saturation levels (+28.4%, P = 0.009) increased in males after 6 days of HDT bed rest, as well as serum hepcidin levels (+36.9% P = 0.005). The increase of transferrin saturation levels persisted after 57 days of HDT bed rest (+13.5%, P = 0.026), suggesting that long-term exposure to microgravity sustainably increases serum iron availability in males, and consequently the risk of iron excess or misdistribution. In females, 6 and 57 days of HDT bed rest did not significantly change serum iron, transferrin saturation, and hepcidin levels. CONCLUSIONS: The data from this exploratory study suggest that 1) AG training does not influence the iron metabolism responses to microgravity; 2) iron metabolism parameters, especially iron availability for cells, are significantly increased in males, but not in females, exposed to long-term simulated microgravity. Due to the small sample size of females, we nevertheless must be cautious before concluding that iron metabolism could differently respond to microgravity in females. Clinical trial registry number: DRKS00015677.
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- 2022
41. Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA bed rest study
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Clément, G., Rittweger, J., Nitsche, A., Doering, W., Frings-Meuthen, P., Hand, O., Frett, T., Noppe, A., Paulke, F., Lecheler, L., Jordan, J., Stern, C., and Mulder, E.
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Physiology ,Physiology (medical) ,analogs ,bed rest ,artificial gravity ,countermeasures ,weightlessness - Abstract
A comprehensive strategy is required to mitigate risks to astronauts’ health, well-being, and performance. This strategy includes developing countermeasures to prevent or reduce adverse responses to the stressors astronauts encounter during spaceflight, such as weightlessness. Because artificial gravity (AG) by centrifugation simultaneously affects all physiological systems, AG could mitigate the effects of weightlessness in multiple systems. In 2019, NASA and the German Aerospace Center conducted a 60-days Artificial Gravity Bed Rest Study with the European Space Agency (AGBRESA). The objectives of this study were to 1) determine if 30 min of AG daily is protective during head down bed rest, and 2) compare the protective effects of a single daily bout (30 min) of AG versus multiple daily bouts (6 × 5 min) of AG (1 Gz at the center of mass) on physiological functions that are affected by weightlessness and by head-down tilt bed rest. The AGBRESA study involved a comprehensive suite of standard and innovative technologies to characterize changes in a broad spectrum of physiological systems. The current article is intended to provide a detailed overview of the methods used during AGBRESA.
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- 2022
42. Altered Functional Connectivity of the Limbic System Years After Preeclampsia: A 7 Tesla Functional MRI Study
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Canjels, L.P.W., Ghossein-Doha, C., Alers, R.J., Rutten, S., van den Kerkhof, M., Schiffer, V.M.M.M., Mulder, E., Gerretsen, S.C., Aldenkamp, A.P., Hurks, P.P.M., van de Ven, V., Jansen, J.F.A., Backes, W.H., Spaanderman, M.E.A., RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Beeldvorming, RS: GROW - R4 - Reproductive and Perinatal Medicine, MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), Obstetrie & Gynaecologie, Dermatologie, MUMC+: MA Arts Assistenten Obstetrie Gynaecologie (9), MUMC+: DA BV Medisch Specialisten Radiologie (9), RS: Carim - B06 Imaging, RS: FPN NPPP I, Section Neuropsychology, RS: FPN CN 3, Perception, MUMC+: DA BV Klinisch Fysicus (9), and MUMC+: MA Medische Staf Obstetrie Gynaecologie (9)
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- 2022
43. A Model for Pre-Pregnancy Prediction of Small for Gestational Age Infancy in a High-Risk Population
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Jorissen, L., Mulder, E., Janssen, E., Al-Nasiry, S., Ghossein-Doha, C., Van Kuijk, S., Spaanderman, M., RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Obstetrie & Gynaecologie, RS: Carim - H01 Clinical atrial fibrillation, Cardiologie, RS: GROW - R4 - Reproductive and Perinatal Medicine, MUMC+: MA Medische Staf Obstetrie Gynaecologie (9), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), RS: CAPHRI - R2 - Creating Value-Based Health Care, Epidemiologie, and MUMC+: KIO Kemta (9)
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- 2022
44. Stronger Blood-Brain Barrier Leakage Years After Preeclampsia: A Dynamic Contrast-Enhanced MRI Study at 7 Tesla
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Canjels, L.P.W., Ghossein-Doha, C., Alers, R.J., van den Kerkhof, M., Schiffer, V.M.M.M., Mulder, E., Gerretsen, S.C., Aldenkamp, A.P., Hurks, P.P.M., van de Ven, V., Jansen, J.F.A., Backes, W.H., Spaanderman, M.E.A., RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Beeldvorming, RS: GROW - R4 - Reproductive and Perinatal Medicine, MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), Obstetrie & Gynaecologie, Dermatologie, MUMC+: MA Arts Assistenten Obstetrie Gynaecologie (9), MUMC+: DA BV Medisch Specialisten Radiologie (9), RS: Carim - B06 Imaging, RS: FPN NPPP I, Section Neuropsychology, RS: FPN CN 3, Perception, MUMC+: DA BV Klinisch Fysicus (9), and MUMC+: MA Medische Staf Obstetrie Gynaecologie (9)
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- 2022
45. Preface to TCHES Volume 2021
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Schwabe, P., Mulder, E., Schwabe, P., and Mulder, E.
- Abstract
Contains fulltext : 250792.pdf (Publisher’s version ) (Open Access)
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- 2022
46. Blood pressure adjustments throughout healthy and hypertensive pregnancy: A systematic review and meta-analysis
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Haas, S., Mulder, E., Schartmann, N., Mohseni, Z., Hasson, F. Abo, Alsadah, F., Kuijk, S. van, Drongelen, J. van, Ghossein-Doha, C., Spaanderman, M.E.A., Haas, S., Mulder, E., Schartmann, N., Mohseni, Z., Hasson, F. Abo, Alsadah, F., Kuijk, S. van, Drongelen, J. van, Ghossein-Doha, C., and Spaanderman, M.E.A.
- Abstract
Contains fulltext : 249885.pdf (Publisher’s version ) (Open Access), Gestational hypertensive complications are preceded by deviant hemodynamic adjustments affecting blood pressure. Our objective was to determine the timing and magnitude of changes in blood pressure during singleton normotensive and hypertensive pregnancies. PubMed (NCBI) and Embase (Ovid) databases were searched for relevant studies up to November 2019. Studies reporting original blood pressure measurements during pregnancy together with a non-pregnant reference measurement were included. Studies including women with a history of cardiovascular or metabolic disease, or women using antihypertensive drugs were excluded. Pooled mean differences between pregnant and non-pregnant women, and absolute blood pressure values were calculated for predefined gestational intervals in normotensive and hypertensive pregnancy, using a random-effects model. Meta-regression analysis was used to analyze group differences in adjustments. In early normotensive pregnancy, both systolic and diastolic blood pressure decreased, reaching their maximum reduction of -4 mmHg (95%CI -6 to -1 mmHg) and -4 mmHg (95%CI, -5 to -3 mmHg), respectively in the second trimester. Thereafter, blood pressure gradually increased towards non-pregnant values. All absolute blood pressure measurements throughout normotensive pregnancy were below 130/80 mmHg. In hypertensive pregnancies, only diastolic blood pressure decreased early in pregnancy. In conclusion, this meta-analysis showed a clinically moderate, but significant mid-pregnancy drop in blood pressure during normotensive pregnancy. Reference curves with absolute values underscore the current liberal cut-off limit for gestational hypertension. A lack of a mid-pregnancy systolic blood pressure drop might reflect increased vascular resistance in women destined to develop hypertensive pregnancy complications.
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- 2022
47. The conservation impacts of ecological disturbance: Time-bound estimates of population loss and recovery for fauna affected by the 2019-2020 Australian megafires
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Nolan, R, Legge, S, Rumpff, L, Woinarski, JCZ, Whiterod, NS, Ward, M, Southwell, DG, Scheele, BC, Nimmo, DG, Lintermans, M, Geyle, HM, Garnett, ST, Hayward-Brown, B, Ensbey, M, Ehmke, G, Ahyong, ST, Blackmore, CJ, Bower, DS, Brizuela-Torres, D, Burbidge, AH, Burns, PA, Butler, G, Catullo, R, Chapple, DG, Dickman, CR, Doyle, KE, Ferris, J, Fisher, D, Gallagher, R, Gillespie, GR, Greenlees, MJ, Hohnen, R, Hoskin, CJ, Hunter, D, Jolly, C, Kennard, M, King, A, Kuchinke, D, Law, B, Lawler, I, Lawler, S, Loyn, R, Lunney, D, Lyon, J, MacHunter, J, Mahony, M, Mahony, S, McCormack, RB, Melville, J, Menkhorst, P, Michael, D, Mitchell, N, Mulder, E, Newell, D, Pearce, L, Raadik, TA, Rowley, JJL, Sitters, H, Spencer, R, Valavi, R, West, M, Wilkinson, DP, Zukowski, S, Nolan, R, Legge, S, Rumpff, L, Woinarski, JCZ, Whiterod, NS, Ward, M, Southwell, DG, Scheele, BC, Nimmo, DG, Lintermans, M, Geyle, HM, Garnett, ST, Hayward-Brown, B, Ensbey, M, Ehmke, G, Ahyong, ST, Blackmore, CJ, Bower, DS, Brizuela-Torres, D, Burbidge, AH, Burns, PA, Butler, G, Catullo, R, Chapple, DG, Dickman, CR, Doyle, KE, Ferris, J, Fisher, D, Gallagher, R, Gillespie, GR, Greenlees, MJ, Hohnen, R, Hoskin, CJ, Hunter, D, Jolly, C, Kennard, M, King, A, Kuchinke, D, Law, B, Lawler, I, Lawler, S, Loyn, R, Lunney, D, Lyon, J, MacHunter, J, Mahony, M, Mahony, S, McCormack, RB, Melville, J, Menkhorst, P, Michael, D, Mitchell, N, Mulder, E, Newell, D, Pearce, L, Raadik, TA, Rowley, JJL, Sitters, H, Spencer, R, Valavi, R, West, M, Wilkinson, DP, and Zukowski, S
- Abstract
Aim: After environmental disasters, species with large population losses may need urgent protection to prevent extinction and support recovery. Following the 2019–2020 Australian megafires, we estimated population losses and recovery in fire-affected fauna, to inform conservation status assessments and management. Location: Temperate and subtropical Australia. Time period: 2019–2030 and beyond. Major taxa: Australian terrestrial and freshwater vertebrates; one invertebrate group. Methods: From > 1,050 fire-affected taxa, we selected 173 whose distributions substantially overlapped the fire extent. We estimated the proportion of each taxon’s distribution affected by fires, using fire severity and aquatic impact mapping, and new distribution mapping. Using expert elicitation informed by evidence of responses to previous wildfires, we estimated local population responses to fires of varying severity. We combined the spatial and elicitation data to estimate overall population loss and recovery trajectories, and thus indicate potential eligibility for listing as threatened, or uplisting, under Australian legislation. Results: We estimate that the 2019–2020 Australian megafires caused, or contributed to, population declines that make 70–82 taxa eligible for listing as threatened; and another 21–27 taxa eligible for uplisting. If so-listed, this represents a 22–26% increase in Australian statutory lists of threatened terrestrial and freshwater vertebrates and spiny crayfish, and uplisting for 8–10% of threatened taxa. Such changes would cause an abrupt worsening of underlying trajectories in vertebrates, as measured by Red List Indices. We predict that 54–88% of 173 assessed taxa will not recover to pre-fire population size within 10 years/three generations. Main conclusions: We suggest the 2019–2020 Australian megafires have worsened the conservation prospects for many species. Of the 91 taxa recommended for listing/uplisting consideration, 84 are now under formal review
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- 2022
48. Implementation of Nationwide Evidence- and Consensus-Based Guidelines to Harmonize Neonatal Care in The Netherlands
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Talsma, E., Jonge, R de, Cassel, F., Loo, Moniek van de, Bijl-Marcus, K. de, Mulder, E. de, Niemarkt, H., Prins, S., Putten, Mayke van der, Stuijvenberg, M. van, Visser, R., Oerlemans, A.J.M., Hogeveen, M., Talsma, E., Jonge, R de, Cassel, F., Loo, Moniek van de, Bijl-Marcus, K. de, Mulder, E. de, Niemarkt, H., Prins, S., Putten, Mayke van der, Stuijvenberg, M. van, Visser, R., Oerlemans, A.J.M., and Hogeveen, M.
- Abstract
Item does not contain fulltext, BACKGROUND: A Dutch committee for National Guidelines in Neonatology developed nineteen evidence- and consensus-based guidelines to be used in all Dutch neonatal intensive care units (NICUs). The primary goal was to make clinical practices more uniform and consistent. OBJECTIVE: This study investigated to what extent the guidelines were implemented and which factors played a role in implementation. STUDY DESIGN: A mixed method study design was used to investigate both the level and the process of implementation. A nationwide, multicenter, cross-sectional survey was performed using a validated instrument for measuring the level of implementation (Normalization MeAsure Development questionnaire, NoMAD). The number of implemented guidelines per NICU and the frequency and content of the amendments that NICUs made to the original consensus guidelines were analyzed. Through semi-structured interviews, perceived barriers and facilitators for implementation were explored. PARTICIPANTS: Fellows and neonatologists working at all ten Dutch level 3-4 NICUs were eligible. RESULTS: On an average, NICUs implemented 12.6 (of 19) guidelines (range 6-17). The Normalization Process Scale was 54 (of 65). Main influencing factors impeding implementation were guideline-related (e.g., unpractical, lengthy guidelines) and personal (e.g., an active representative responsible for local implementation). CONCLUSION: The implementation of our guidelines appears to be successful. Ways for improvement can be distinguished in personal, guideline-related and external factors. Empowerment of local representatives was considered most essential.
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- 2022
49. The conservation impacts of ecological disturbance: Time-bound estimates of population loss and recovery for fauna affected by the 2019–2020 Australian megafires
- Author
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Legge, S., Rumpff, L., Woinarski, J.C.Z., Whiterod, N.S., Ward, M., Southwell, D.G., Scheele, B.C., Nimmo, D.G., Lintermans, M., Geyle, H.M., Garnett, S.T., Hayward-Brown, B., Ensbey, M., Ehmke, G., Ahyong, S.T., Blackmore, C.J., Bower, D.S., Brizuela-Torres, Diego, Burbidge, A.H., Burns, P.A., Butler, G., Catullo, R., Chapple, D.G., Dickman, C.R., Doyle, K.E., Ferris, J., Fisher, D., Gallagher, R., Gillespie, G.R., Greenlees, M.J., Hohnen, R., Hoskin, C.J., Hunter, D., Jolly, C., Kennard, M., King, A., Kuchinke, D., Law, B., Lawler, I., Lawler, S., Loyn, R., Lunney, D., Lyon, J., MacHunter, J., Mahony, M., Mahony, S., McCormack, R.B., Melville, J., Menkhorst, P., Michael, D., Mitchell, M., Mulder, E., Newell, D., Pearce, L., Raadik, T.A., Rowley, J.J.L., Sitters, H., Spencer, R., Valavi, R., West, M., Wilkinson, D.P., Zukowski, S., Legge, S., Rumpff, L., Woinarski, J.C.Z., Whiterod, N.S., Ward, M., Southwell, D.G., Scheele, B.C., Nimmo, D.G., Lintermans, M., Geyle, H.M., Garnett, S.T., Hayward-Brown, B., Ensbey, M., Ehmke, G., Ahyong, S.T., Blackmore, C.J., Bower, D.S., Brizuela-Torres, Diego, Burbidge, A.H., Burns, P.A., Butler, G., Catullo, R., Chapple, D.G., Dickman, C.R., Doyle, K.E., Ferris, J., Fisher, D., Gallagher, R., Gillespie, G.R., Greenlees, M.J., Hohnen, R., Hoskin, C.J., Hunter, D., Jolly, C., Kennard, M., King, A., Kuchinke, D., Law, B., Lawler, I., Lawler, S., Loyn, R., Lunney, D., Lyon, J., MacHunter, J., Mahony, M., Mahony, S., McCormack, R.B., Melville, J., Menkhorst, P., Michael, D., Mitchell, M., Mulder, E., Newell, D., Pearce, L., Raadik, T.A., Rowley, J.J.L., Sitters, H., Spencer, R., Valavi, R., West, M., Wilkinson, D.P., and Zukowski, S.
- Abstract
Aim After environmental disasters, species with large population losses may need urgent protection to prevent extinction and support recovery. Following the 2019–2020 Australian megafires, we estimated population losses and recovery in fire-affected fauna, to inform conservation status assessments and management. Location Temperate and subtropical Australia. Time period 2019–2030 and beyond. Major taxa Australian terrestrial and freshwater vertebrates; one invertebrate group. Methods From > 1,050 fire-affected taxa, we selected 173 whose distributions substantially overlapped the fire extent. We estimated the proportion of each taxon’s distribution affected by fires, using fire severity and aquatic impact mapping, and new distribution mapping. Using expert elicitation informed by evidence of responses to previous wildfires, we estimated local population responses to fires of varying severity. We combined the spatial and elicitation data to estimate overall population loss and recovery trajectories, and thus indicate potential eligibility for listing as threatened, or uplisting, under Australian legislation. Results We estimate that the 2019–2020 Australian megafires caused, or contributed to, population declines that make 70–82 taxa eligible for listing as threatened; and another 21–27 taxa eligible for uplisting. If so-listed, this represents a 22–26% increase in Australian statutory lists of threatened terrestrial and freshwater vertebrates and spiny crayfish, and uplisting for 8–10% of threatened taxa. Such changes would cause an abrupt worsening of underlying trajectories in vertebrates, as measured by Red List Indices. We predict that 54–88% of 173 assessed taxa will not recover to pre-fire population size within 10 years/three generations. Main conclusions We suggest the 2019–2020 Australian megafires have worsened the conservation prospects for many species. Of the 91 taxa recommended for listing/uplisting consideration, 84 a
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- 2022
50. The meaning of screening:detection of brain metastasis in the adjuvant setting for stage III melanoma
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Derks, S. H.A.E., de Joode, K., Mulder, E. E.A.P., Ho, L. S., Joosse, A., de Jonge, M. J.A., Verhoef, C., Grünhagen, D. J., Smits, M., van den Bent, M. J., van der Veldt, A. A.M., Derks, S. H.A.E., de Joode, K., Mulder, E. E.A.P., Ho, L. S., Joosse, A., de Jonge, M. J.A., Verhoef, C., Grünhagen, D. J., Smits, M., van den Bent, M. J., and van der Veldt, A. A.M.
- Abstract
BACKGROUND: The incidence of melanoma is increasing and 37% of patients with metastatic melanoma eventually have brain metastasis (BM). Currently, there is no consensus on screening for BM in patients with resected stage III melanoma. However, given the high incidence of BM, routine screening magnetic resonance imaging (MRI) of the brain is considered in patients with completely resected stage III melanoma before the start of adjuvant treatment. The aim of this study was to assess the yield of screening for BM in these patients.MATERIALS AND METHODS: A single-center cohort study was carried out in the Erasmus MC, Rotterdam, The Netherlands, a large tertiary referral center for patients with melanoma. Eligible patients with complete resection of stage III melanoma and a screening MRI of the brain, made within 12 weeks after resection and before adjuvant treatment (programmed cell death protein 1 inhibitors, dabrafenib-trametinib), available between 1 August 2018 and 1 January 2021, were included.RESULTS: A total of 202 patients were included. Eighteen (8.9%) of 202 patients had extracranial metastasis at screening. Two (1.1%) of the remaining 184 patients had BM at screening, resulting in a switch from adjuvant treatment to ipilimumab-nivolumab. At a median follow-up of 21.2 months, BM was detected in another 4 (2.4%) of 166 patients who started with adjuvant treatment.CONCLUSIONS: The yield of screening MRI of the brain is low after complete resection of stage III melanoma, before the start of adjuvant treatment. Therefore, routine screening MRI is not recommended in this setting.
- Published
- 2022
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