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3 results on '"Mulayim, Mehmet K."'

1. Clinical practice guidelines for the diagnosis and treatment of scabies

Author

Harman, Mehmet, Akyol, Melih, Uzun, Soner, Yürekli, Aslan, Velipasaoglu, Sevtap, Mulayim, Mehmet K., Durdu, Murat, Harman, Mehmet, Akyol, Melih, Uzun, Soner, Yürekli, Aslan, Velipasaoglu, Sevtap, Mulayim, Mehmet K., and Durdu, Murat

Abstract

Scabies, caused by the Sarcoptes scabiei var hominis mite burrowing into the skin, is a highly contagious disease characterized by intense nocturnal itching. Its global impact is considerable, affecting more than 200 million individuals annually and posing significant challenges to healthcare systems worldwide. Transmission occurs primarily through direct skin-to-skin contact, contributing to its widespread prevalence and emergence as a substantial public health concern affecting large populations. This review presents consensus-based clinical practice guidelines for diagnosing and managing scabies, developed through the fuzzy Delphi method by dermatology, parasitology, pediatrics, pharmacology, and public health experts. The presence of burrows containing adult female mites, their eggs, and excreta is the diagnostic hallmark of scabies. Definitive diagnosis typically involves direct microscopic examination of skin scrapings obtained from these burrows, although dermoscopy has become a diagnostic tool in clinical practice. Treatment modalities encompass topical agents, such as permethrin, balsam of Peru, precipitated sulfur, and benzyl benzoate. In cases where topical therapy proves inadequate or in instances of crusted scabies, oral ivermectin is recommended as a systemic treatment option. This comprehensive approach addresses the diagnostic and therapeutic challenges associated with scabies, optimizing patient care, and management outcomes.

Published
2024

2. Clinical practice guidelines for the diagnosis and treatment of cutaneous leishmaniasis in Turkey

Author

Melih Akyol, Yelda Kapicioglu, Yavuz Yesilova, Mehmet Salih Gürel, Murat Borlu, Yusuf Özbel, Ayşe Akman-Karakaş, Bilge Fettahlıoğlu Karaman, Mehmet Harman, Tamer Irfan Kaya, Soner Uzun, Seray Töz, Çiğdem Asena Doğramacı, Mustafa Aksoy, Sema Aytekin, Murat Durdu, Orhan Ozgoztasi, Mehmet Kamil Mülayim, Esra İnan Doğan, Çukurova Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Karaman, Bilge Fettahlıoğlu, [Uzun, Soner -- Akman-Karakas, Ayse] Akdeniz Univ, Dept Dermatol, Fac Med, TR-07059 Antalya, Turkey -- [Gurel, Mehmet S.] Medeniyet Univ, Dept Dermatol, Fac Med, Istanbul, Turkey -- [Durdu, Murat] Baskent Univ, Dept Dermatol, Fac Med, Adana, Turkey -- [Akyol, Melih] Cumhuriyet Univ, Dept Dermatol, Fac Med, Sivas, Turkey -- [Karaman, Bilge Fettahlioglu] Cukurova Univ, Dept Dermatol, Fac Med, Adana, Turkey -- [Aksoy, Mustafa] Harran Univ, Dept Dermatol, Fac Med, Sanliurfa, Turkey -- [Aytekin, Sema] Haydarpasa Numune Training & Res Hosp, Dept Dermatol, Istanbul, Turkey -- [Borlu, Murat] Erciyes Univ, Dept Dermatol, Fac Med, Kayseri, Turkey -- [Dogan, Esra Inan] Adiyaman Univ, Dept Dermatol, Fac Med, Adiyaman, Turkey -- [Dogramaci, Cigdem Asena] Mustafa Kemal Univ, Dept Dermatol, Fac Med, Antakya, Turkey -- [Kapicioglu, Yelda] Inonu Univ, Dept Dermatol, Fac Med, Malatya, Turkey -- [Kaya, Tamer I.] Mersin Univ, Dept Dermatol, Fac Med, Mersin, Turkey -- [Mulayim, Mehmet K.] Sutcu Imam Univ, Dept Dermatol, Fac Med, Kahramanmaras, Turkey -- [Ozbel, Yusuf -- Toz, Seray Ozensoy] Ege Univ, Dept Parasitol, Fac Med, Izmir, Turkey -- [Ozgoztasi, Orhan] Gaziantep Univ, Dept Dermatol, Fac Med, Gaziantep, Turkey -- [Yesilova, Yavuz] Lokman Hekim Hosp, Dept Dermatol, Van, Turkey -- [Harman, Mehmet] Dicle Univ, Dept Dermatol, Fac Med, Diyarbakir, Turkey, uzun, soner -- 0000-0001-7059-5474, Durdu, Murat -- 0000-0003-1247-3932, and Çukurova Üniversitesi

Subjects
Antimony, medicine.medical_specialty, Delphi Technique, Turkey, FEATURES, 030231 tropical medicine, MEDLINE, Antiprotozoal Agents, Leishmaniasis, Cutaneous, MEGLUMINE ANTIMONIATE, Dermatology, Disease, Diagnosis, Differential, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, DONOVANI, Cutaneous leishmaniasis, Amphotericin B, medicine, Organometallic Compounds, Humans, Intensive care medicine, Evidence-Based Medicine, business.industry, Incidence (epidemiology), Leishmaniasis, Guideline, Evidence-based medicine, EFFICACY, medicine.disease, Cryotherapy, Parasitic disease, Practice Guidelines as Topic, INTRALESIONAL SODIUM STIBOGLUCONATE, TRIAL, business, SANLIURFA, Algorithms
Abstract

WOS: 000437833900024, PubMed ID: 29663351, Background Cutaneous leishmaniasis ( CL) is a vector- born parasitic disease characterized by various skin lesions that cause disfiguration if healed spontaneously. Although CL has been endemic for many years in the southern regions of Turkey, an increasing incidence in nonendemic regions is being observed due to returning travelers and, more recently, due to Syrian refugees. Thus far, a limited number of national guidelines have been proposed, but no common Turkish consensus has emerged. Objectives The aim of this study was to develop diagnostic and therapeutic guidelines for the management of CL in Turkey. Methods This guideline is a consensus text prepared by 18 experienced CL specialists who have been working for many years in areas where the disease is endemic. The Delphi method was used to determine expert group consensus. Initially, a comprehensive list of items about CL was identified, and consensus was built from feedback provided by expert participants from the preceding rounds. Results Evidence- based and expert- based recommendations through diagnostic and therapeutic algorithms according to local availability and conditions are outlined. Conclusion Because CL can mimic many other skin diseases, early diagnosis and early treatment are very important to prevent complications and spread of the disease. The fastest and easiest diagnostic method is the leishmanial smear. The most common treatment is the use of local or systemic pentavalent antimony compounds.

Published
2017

3. Assessment of Oxidative/Nitrosative Stress and Raftlin in Vitiligo.

Author

Mulayim MK, Kurutas EB, Nazik H, and Ozturk P

Abstract

Background: Vitiligo is a chronic skin disease characterized by white macules on the skin due to loss of melanocytes. Although there are many theories about the etiopathogenesis of the disease, oxidative stress is identified as an important determinant in the etiology of vitiligo. In recent years, Raftlin has been shown to play a role in many inflammatory diseases., Aims: The aim of this study was to compare the patients with vitiligo and the control group to determine both oxidative/nitrosative stress markers and Raftlin levels., Materials and Methods: This study was designed prospectively between September 2017 and April 2018. Twenty-two patients diagnosed with vitiligo and 15 healthy people as the control group were included in the study. Blood samples collected to determine oxidative/nitrosative stress, the antioxidant enzyme, and Raftlin levels were sent to the biochemistry laboratory., Results: In patients with vitiligo, the activities of catalase, superoxide dismutase, glutathione peroxidase, and glutathione S transferase were significantly lower than in the control group ( P < 0.0001). In vitiligo patients, the levels of malondialdehyde, nitric oxide, nitrotyrosine (3-NTx), and Raftlin were significantly higher than in the control group ( P < 0.0001)., Conclusions: The results of the study support that oxidative stress and nitrosative stress may play a role in the pathogenesis of vitiligo. In addition, the Raftlin level, a new biomarker of inflammatory diseases, was found high in patients with vitiligo., Competing Interests: There are no conflicts of interest., (Copyright: © 2022 Indian Journal of Dermatology.)

Published
2022
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