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5. Trichomonas vaginalis adherence phenotypes and extracellular vesicles impact parasite survival in a novel in vivo model of pathogenesis.

Author

Molgora, Brenda, Mukherjee, Sandip, Baumel-Alterzon, Sharon, Santiago, Fernanda, Muratore, Katherine, Sisk, Anthony, Mercer, Frances, and Johnson, Patricia

Subjects
Male, Humans, Female, Animals, Mice, Trichomonas vaginalis, Parasites, Trichomonas Infections, Vagina, Extracellular Vesicles
Abstract

Trichomonas vaginalis is a human infective parasite responsible for trichomoniasis-the most common, non-viral, sexually transmitted infection worldwide. T. vaginalis resides exclusively in the urogenital tract of both men and women. In women, T. vaginalis has been found colonizing the cervix and vaginal tract while in men it has been identified in the upper and lower urogenital tract and in secreted fluids such as semen, urethral discharge, urine, and prostatic fluid. Despite the over 270 million cases of trichomoniasis annually worldwide, T. vaginalis continues to be a highly neglected organism and thus poorly studied. Here we have developed a male mouse model for studying T. vaginalis pathogenesis in vivo by delivering parasites into the murine urogenital tract (MUT) via transurethral catheterization. Parasite burden was assessed ex-vivo using a nanoluciferase-based gene expression assay which allowed quantification of parasites pre- and post-inoculation. Using this model and read-out approach, we show that T. vaginalis can be found within MUT tissue up to 72 hrs post-inoculation. Furthermore, we also demonstrate that parasites that exhibit increased parasite adherence in vitro also have higher parasite burden in mice in vivo. These data provide evidence that parasite adherence to host cells aids in parasite persistence in vivo and molecular determinants found to correlate with host cell adherence in vitro are applicable to infection in vivo. Finally, we show that co-inoculation of T. vaginalis extracellular vesicles (TvEVs) and parasites results in higher parasite burden in vivo. These findings confirm our previous in vitro-based predictions that TvEVs assist the parasite in colonizing the host. The establishment of this pathogenesis model for T. vaginalis sets the stage for identifying and examining parasite factors that contribute to and influence infection outcomes.

Published
2023

6. Clinical performance validation of the STANDARD G6PD test: A multi-country pooled analysis.

Author

Adissu, Wondimagegn, Brito, Marcelo, Garbin, Eduardo, Macedo, Marcela, Monteiro, Wuelton, Mukherjee, Sandip, Myburg, Jane, Alam, Mohammad, Bancone, Germana, Bansil, Pooja, Pal, Sampa, Sharma, Abhijit, Zobrist, Stephanie, Bryan, Andrew, Chu, Cindy, Das, Santasabuj, Domingo, Gonzalo, Hann, Amanda, Kublin, James, Lacerda, Marcus, Layton, Mark, Ley, Benedikt, Murphy, Sean, Nosten, Francois, Pereira, Dhélio, Price, Ric, Talukdar, Arunansu, Yilma, Daniel, and Gerth-Guyette, Emily

Subjects
Female, Humans, Primaquine, Glucosephosphate Dehydrogenase Deficiency, Retrospective Studies, Antimalarials, Malaria, Vivax
Abstract

INTRODUCTION: Screening for G6PD deficiency can inform disease management including malaria. Treatment with the antimalarial drugs primaquine and tafenoquine can be guided by point-of-care testing for G6PD deficiency. METHODS AND FINDINGS: Data from similar clinical studies evaluating the performance of the STANDARD G6PD Test (SD Biosensor, South Korea) conducted in Bangladesh, Brazil, Ethiopia, India, Thailand, the United Kingdom, and the United States were pooled. Test performance was assessed in a retrospective analysis on capillary and venous specimens. All study sites used spectrophotometry for reference G6PD testing, and either the HemoCue or complete blood count for reference hemoglobin measurement. The sensitivity of the STANDARD G6PD Test using the manufacturer thresholds for G6PD deficient and intermediate cases in capillary specimens from 4212 study participants was 100% (95% Confidence Interval (CI): 97.5%-100%) for G6PD deficient cases with 60% on the reference assay. The negative predictive value for females with G6PD activity >60% was 99.6% (95% CI 99.1%-99.8%) on capillary specimens. Sensitivity among 396 P. vivax malaria cases was 100% (69.2%-100.0%) for both deficient and intermediate cases. Across the full dataset, 37% of those classified as G6PD deficient or intermediate resulted from true normal cases. Despite this, over 95% of cases would receive correct treatment with primaquine, over 87% of cases would receive correct treatment with tafenoquine, and no true G6PD deficient cases would be treated inappropriately based on the result of the STANDARD G6PD Test. CONCLUSIONS: The STANDARD G6PD Test enables safe access to drugs which are contraindicated for individuals with G6PD deficiency. Operational considerations will inform test uptake in specific settings.

Published
2023

11. Performance Analysis of Professional Higher Education Programmes Driven by Students Perception: A Latent Variable Computation Model for Industry 5.0

Author

Roy, Bhaswati, Mukherjee, Sandip, Bhattacherjee, Niloy Kumar, Samanta, Sayanti, Gupta, Subir, Bhattacharyya, Siddhartha, Series Editor, Kacprzyk, Janusz, Series Editor, Koeppen, Mario, Series Editor, Snasel, Vaclav, Series Editor, Kruse, Rudolf, Series Editor, Banerjee, Jyoti Sekhar, editor, De, Debashis, editor, and Mahmud, Mufti, editor

Published
2023
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19. List of contributors

Author

Banerjee, Oly, primary, Barrientos, Antoni, additional, Blanchard, Christopher, additional, Bordoni, Laura, additional, Budiono, Boris, additional, Cantú-Casas, Sara, additional, Castro-Sepulveda, Mauricio, additional, de Souza Freire, Thiago, additional, de Souza-Pinto, Nadja C., additional, Fasciolo, Gianluca, additional, Francis, Nidhish, additional, Frantz, Marie-Céline, additional, García-Rivas, Gerardo, additional, Garten, Antje, additional, Ghrairi, Taoufik, additional, Ghzaiel, Imen, additional, Gonzalez, Michael J., additional, Gowayed, Mennatallah A., additional, Jamali, Zhaleh, additional, Jannas-Vela, Sebastian, additional, Kamel, Maher A., additional, Koga, Yasutoshi, additional, Ksila, Mohamed, additional, Latruffe, Norbert, additional, Lavery, Gareth G., additional, Li, Si-Quan, additional, Liu, Zhigang, additional, Lizard, Gérard, additional, López-Lluch, Guillermo, additional, Lozano, Omar, additional, Masmoudi-Kouki, Olfa, additional, Mendoza Muraira, Paolo I., additional, Meziane, Smail, additional, Miranda-Massari, Jorge R., additional, Moussa, Yousra Y., additional, Mukherjee, Sandip, additional, Napolitano, Gaetana, additional, Nury, Thomas, additional, Olalde, Jose, additional, Ostojic, Sergej M., additional, Pan, Huajun, additional, Pinkerton, Meredith, additional, Prasad, Pooja, additional, Prost-Camus, Emmanuelle, additional, Saari, Sina, additional, Sack, Michael N., additional, Saji, Nancy, additional, Salimi, Ahmad, additional, Santhakumar, Abishek, additional, Selvasudha, Nandakumar, additional, Sergi, Domenico, additional, Shirmard, Leila Rezaie, additional, Singh, Siddhartha, additional, Sivadas, Sneha, additional, Solis-Castañol, Diego, additional, Srividhya, Ravichandran, additional, Surai, Peter F., additional, Vasanthi, Hannah R., additional, Vejux, Anne, additional, Venditti, Paola, additional, Vervandier-Fasseur, Dominique, additional, Yammine, Aline, additional, Yan, Chunhong, additional, Zarrouk, Amira, additional, and Zweers, Heidi, additional

Published
2023
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22. Contributors

Author

Abbate, Antonio, primary, Aksentijevich, Ivona, additional, Amaral, Marcelo Pires, additional, Andrade-Silva, Magaiver, additional, Angosto-Bazarra, Diego, additional, Antonioli, Luca, additional, Aral, Kübra, additional, Aróstegui, Juan I., additional, Barlow, Jillian, additional, Benvenuti, Laura, additional, Bernardini, Nunzia, additional, Bertinaria, Massimo, additional, Biasizzo, Monika, additional, Bortoluci, Karina Ramalho, additional, Boucher, Dave, additional, Branco, Laura Migliari, additional, Brough, David, additional, Broz, Petr, additional, Bryant, Clare E., additional, Cahill, Mark, additional, Campbell, Matthew, additional, Cho, Soo Jung, additional, Christgen, Shelbi, additional, Coll, Rebecca C., additional, Couillin, Isabelle, additional, Cyr, Brianna, additional, Dalmon, Sarah, additional, de Rivero Vaccari, Juan Pablo, additional, Di Virgilio, Francesco, additional, Dorfleutner, Andrea, additional, Doyle, Sarah L., additional, D'Antongiovanni, Vanessa, additional, Feldstein, Ariel E., additional, Fornai, Matteo, additional, García-Palenciano, Carlos, additional, Gastaldi, Simone, additional, Geyer, Matthias, additional, Ghiringhelli, François, additional, Giuliani, Anna Lisa, additional, González-Navajas, José Manuel, additional, Hafner-Bratkovič, Iva, additional, Hamarsheh, Shaima'a, additional, Heneka, Michael T., additional, Henry, Thomas, additional, Hikima, Jun-ichi, additional, Hochheiser, Inga V., additional, Hogg, Alexander, additional, Hooftman, Alexander, additional, Hoyle, Christopher, additional, Huang, Yin, additional, Huot-Marchand, Sarah, additional, Hurtado-Navarro, Laura, additional, Jha, Sushmita, additional, Kanneganti, Thirumala-Devi, additional, Kaufmann, Benedikt, additional, Kim, Andrea D., additional, Kopitar-Jerala, Nataša, additional, Kron, Jordana, additional, Lage, Silvia Lucena, additional, Lozano-Ruiz, Beatriz, additional, Marini, Elisabetta, additional, Matchett, Billie, additional, Mauro, Adolfo G., additional, Mezzaroma, Eleonora, additional, Milward, Michael R., additional, Mizuno Watanabe, Ingrid Kazue, additional, Morimoto, Natsuki, additional, Mukherjee, Sandip, additional, Orzáez, Mar, additional, O'Neill, Luke A.J., additional, Pelegrín, Pablo, additional, Pellegrini, Carolina, additional, Perrichet, Anaïs, additional, Picó, Joanna, additional, Potere, Nicola, additional, Pronko, Alexander, additional, Ravichandran, Kishore Aravind, additional, Riteau, Nicolas, additional, Robinson, Kim S., additional, Rébé, Cédric, additional, Salloum, Fadi N., additional, Sancho, Mónica, additional, Sandstrom, Andrew, additional, Saraiva Câmara, Niels Olsen, additional, Schmidt, Florian I., additional, Shan, Liang, additional, Silke, Eoin, additional, Soriano-Teruel, Paula M., additional, Stehlik, Christian, additional, Stout-Delgado, Heather, additional, Theiss, Arianne L., additional, Ting, Jenny P.-Y., additional, Toldo, Stefano, additional, Tsakem, Elviche L., additional, Tweedell, Rebecca E., additional, Tzoumpa, Amalia, additional, Venuprasad, K., additional, Wellens, Rose, additional, Zeiser, Robert, additional, Zhong, Franklin L., additional, and Zotta, Alessia, additional

Published
2023
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26. Contributors

Author

Aarthy, Murali, primary, Acharya, Bidisha, additional, Aggarwal, Priyanka, additional, Ahmad, Nabeel, additional, Aiswarya, Natarajan, additional, Alici, Hakan, additional, Al-Khafaji, Khattab, additional, Assaiya, Anshul, additional, Bansal, Saurabh, additional, Bhar, Suparna, additional, Bhardwaj, Aparna, additional, Bhatia, Dhiraj, additional, Bhavesh, Neel Sarovar, additional, Bons, Joanna, additional, Chattopadhyay, Krishnananda, additional, Chetri, Purna Bahadur, additional, Coskuner-Weber, Orkid, additional, De, Soumya, additional, Dodero, Veronica Isabel, additional, Elias, Jack A., additional, Emperador, Agusti, additional, Giambruno, Roberto, additional, Giampà, Marco, additional, Giri, Rajanish, additional, Graether, Steffen P., additional, Gupta, Akshita, additional, Gupta, Smita, additional, Haque, Md Anzarul, additional, Hasekioglu, Orkun, additional, Hassan, Md Imtaiyaz, additional, Hebbar, Prajna N., additional, Hema Naveena, A., additional, Herrera, Maria Georgina, additional, Illig, Alexander-Maurice, additional, Islam, Asimul, additional, Janežič, Matej, additional, Jeyakanthan, Jeyaraman, additional, Kamle, Suchitra, additional, Kasahara, Kota, additional, Kaur, Punit, additional, Khan, Heena, additional, Kumar, Janesh, additional, Kumar, Prateek, additional, Kumar, Ritesh, additional, Kumar, Saravanan, additional, Kumar, Vijay, additional, Kumari, Pooja, additional, Kumari, Varsha, additional, Kundu, Bishwajit, additional, Lee, Chun Geun, additional, Li, Dawei, additional, Lin, Xubo, additional, Maiti, Snigdha, additional, Mandal, Narattam, additional, Mhashal, Anil, additional, Mishra, Parul, additional, Mohan, Ajitha, additional, Mukherjee, Sandip, additional, Mukherjee, Sunandan, additional, Nag, Niharika, additional, Nageswar, Koomity V., additional, Nasim, Fouzia, additional, Nayak, Santoshi, additional, Neog, Siddharth, additional, Nithin, Chandran, additional, O’Broin, Amy, additional, Olubiyi, Olujide O., additional, Orellana, Laura, additional, Padhi, Aditya K., additional, Padhy, Amrita Arpita, additional, Patil, Dipak N., additional, Prajapati, Vijay Kumar, additional, Qureshi, Insaf Ahmed, additional, Rahul, Chandrashekar Narayanan, additional, Rajwar, Anjali, additional, Ramadan, Kristijan, additional, Rashmi, S., additional, Ratnakar, Tadi Sai, additional, Rawat, Arun Kumar, additional, Rose, Jacob, additional, Roy, Anwesha, additional, Rupert, Jakob, additional, Sahoo, Subhashree, additional, Saibo, Nikita V., additional, Samantray, Suman, additional, Samarth, Nikhil H., additional, Sanjeevi, Madhumathi, additional, Sannigrahi, Achinta, additional, Sasidharan, Santanu, additional, Saudagar, Prakash, additional, Schilling, Birgit, additional, Sekar, Kanagaraj, additional, Sharma, Mansi, additional, Sharma, Pradeep, additional, Sharma, Sujata, additional, Sharma, Vinita, additional, Shivani, Kummari, additional, Singh, Abhay Narayan, additional, Singh, Anamika, additional, Singh, Appu K., additional, Singh, Meenakshi, additional, Singh, Sanjeev Kumar, additional, Singh, Satyendra, additional, Singh, Shailza, additional, Singh, Shalini, additional, Singh, Sudhir Kumar, additional, Singh, Tej P., additional, Taskin-Tok, Tugba, additional, Theiss, Arianne L., additional, Tonali, Nicolo, additional, Tripathi, Timir, additional, Trivedi, Vishal, additional, Uversky, Vladimir N., additional, Vaswani, Payal, additional, Venuprasad, K., additional, Zacco, Elsa, additional, and Zhang, Kam Y.J., additional

Published
2022
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30. Uncovering the coronavirus outbreak: present understanding and future research paths.

Author

Roy, Jayati, Banerjee, Arnab, Mukherjee, Sandip, and Maji, Bithin K.

Subjects
VACCINE development, MENTAL health, HEALTH status indicators, MICROBIAL virulence, REPRODUCTIVE health, SOCIOECONOMIC factors, TOLL-like receptors, MYOCARDIAL injury, EPIDEMICS, PUBLIC health, COVID-19, SARS-CoV-2, GENOMES
Abstract

The review discusses the pathophysiological mechanisms of SARS-CoV-2, the modes of transmission, and the long-term health consequences of COVID-19, emphasizing the importance of research and successful public health initiatives. COVID-19 taxonomy, pathophysiology, symptomatology, and epidemiological importance are the key objects of this research paper. This review explains how COVID-19 affects different systems of the body, including respiratory, cardiovascular, and reproductive systems of the human body. It describes the modes of entry of the virus into the cell; more precisely, ACE2 and TMPRSS2 in viral entry. In addition, the present study analyzes the situation of COVID-19 in India regarding vaccine development and the transmission rate related to socioeconomic factors. The manifestation of COVID-19 presents a lot of symptoms and post-acute problems, issues which are seriously impacting mental health and physical health as well. The present review summarizes current research into pathogenicity and the mode of virus transmission, together with immunological responses. Coupled with strong vaccination programs, public health initiatives should hold the key to fighting this pandemic. Long-term effects and the development of treatment methods will need further study, as ambiguities on COVID-19 remain. Multidisciplinary collaboration across healthcare sectors in this respect is of paramount importance for the prevention of further spread and protection of public health. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Folic acid protects against fluoride-induced oxidative stress and testicular damage in rats

Author

Ray Dibyendu, Chatterjee Tiasa, Monalisha Das, Panda Pradip, and Mukherjee Sandip

Subjects
sodium fluoride, folic acid, testicular damage, sperm, oxidative stress, antioxidants, Medicine
Abstract

Objective: To investigate the effects of folic acid on testicular oxidative damage in sodium fluoride-induced male Wistar rats. Methods: A total of 24 male Wistar rats were divided into 4 groups: the control, sodium fluoride (fed with 100 mg/L sodium fluoride through drinking water orally for 21 days), folic acid (36 μg/kg body weight/day, orally), and sodium fluoride plus folic acid (received similar dose orally) groups. At the end of 21 days, epididymal sperm parameters, biochemical analysis of testicular tissue, and serum hormonal levels were performed along with histopathological studies. Results: Sodium fluoride intoxication resulted in marked reduction in gonado somatic index, serum luteinizing hormone, and testosterone level along with 3 β -hydroxysteroid dehydrogenase and 17 β -hydroxysteroid dehydrogenase activities. In addition, reduction in sperm density, as well as loss of sperm motility and sperm viability, were also observed. Besides, increased levels of testicular malondialdehyde, nitrite, interleukin-6 and tumor necrosis factor- α as well as decreased levels of superoxide dismutase and catalase activities and reduced glutathione content were found to be associated with this toxicity. Folic acid co-treatment, on the other hand, could prevent all the sodium fluoride-induced testicular pathophysiology and oxidative stress related parameters. Histological examinations of testicular sections from the experimental rats supported these results. Conclusions: Combining all, this study suggests that being an antioxidant, folic acid plays a beneficial role against fluoride-induced adverse effects on the male reproductive system.

Published
2021
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45. Patient-specific ascending aortic intervention criteria.

Author

Kalogerakos, Paris D, Zafar, Mohammad A, Li, Yupeng, Ellauzi, Hesham, Mukherjee, Sandip K, Ziganshin, Bulat A, Rizzo, John A, and Elefteriades, John A

Subjects
ASCENDING aorta aneurysms, THORACIC aneurysms, AORTA, BODY surface area, GAUSSIAN distribution
Abstract

OBJECTIVES Ascending aortic aneurysms pose a different risk to each patient. We aim to provide personalized risk stratification for such patients based on sex, age, body surface area and aneurysm location (root versus ascending). METHODS Root and ascending diameters, and adverse aortic events (dissection, rupture, death) of ascending thoracic aortic aneurysm patients were analysed. Aortic diameter was placed in context vis-a-vis the normal distribution in the general population with similar sex, age and body surface area, by conversion to z scores. These were correlated of major adverse aortic events, producing risk curves with 'hinge points' of steep risk, constructed separately for the aortic root and mid-ascending aorta. RESULTS A total of 1162 patients were included. Risk curves unveiled generalized thresholds of z  = 4 for the aortic root and z  = 5 for the mid-ascending aorta. These correspond to individualized thresholds of less than the standard criterion of 5.5 cm in the vast majority of patients. Indicative results include a 75-year-old typical male with 2.1 m2 body surface area, who was found to be at increased risk of adverse events if root diameter exceeds 5.15 cm, or mid ascending exceeds 5.27 cm. An automated calculator is presented, which identifies patients at high risk of adverse events based on sex, age, height, weight, and root and ascending size. CONCLUSIONS This analysis exploits a large sample of aneurysmal patients, demographic features of the general population, pre-dissection diameter, discrimination of root and supracoronary segments, and statistical tools to extract thresholds of increased risk tailor-made for each patient. [ABSTRACT FROM AUTHOR]

Published
2024
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